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Thematische Bibliographien / Iron Therapeutic use Tanzania / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Iron Therapeutic use Tanzania“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 28. Januar 2023

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1

Hatcher, Heather C., Ravi N. Singh, Frank M. Torti, and Suzy V. Torti. "Synthetic and natural iron chelators: therapeutic potential and clinical use." Future Medicinal Chemistry 1, no. 9 (December 2009): 1643–70. http://dx.doi.org/10.4155/fmc.09.121.

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2

Bhandari, Bharti, and Anita Mehta. "Serum iron and serum retinol level of severe acute malnourished children on therapeutic intervention with WHO/UNICEF recommended therapeutic food and home based therapeutic food." International Journal of Contemporary Pediatrics 8, no. 2 (January 22, 2021): 337. http://dx.doi.org/10.18203/2349-3291.ijcp20210125.

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Background: The prevalence of anaemia and vitamin A deficiency among children with severe acute malnutrition (SAM) and their correction during nutritional rehabilitation are not well documented. This study assessed serum iron and serum retinol levels, effect of ready-to-use therapeutic foods (RUTF) and home based treatment on levels of serum iron and serum retinol level in SAM children.Methods: This was a simple randomised controlled trial in 6-59 months old children with SAM. Two groups of 70 each were divided, one was given RUTF and other home based food comparable to RUTF. Serum retinol and

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3

Boshuizen, M., K. van der Ploeg, L. von Bonsdorff, B. J. Biemond, S. S. Zeerleder, R. van Bruggen, and N. P. Juffermans. "Therapeutic use of transferrin to modulate anemia and conditions of iron toxicity." Blood Reviews 31, no. 6 (November 2017): 400–405. http://dx.doi.org/10.1016/j.blre.2017.07.005.

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Makis, Alexandros, Ersi Voskaridou, Ioannis Papassotiriou та Eleftheria Hatzimichael. "Novel Therapeutic Advances in β-Thalassemia". Biology 10, № 6 (18 червня 2021): 546. http://dx.doi.org/10.3390/biology10060546.

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The main characteristic of the pathophysiology of β-thalassemia is reduced β-globin chain production. The inevitable imbalance in the α/β-globin ratio and α-globin accumulation lead to oxidative stress in the erythroid lineage, apoptosis, and ineffective erythropoiesis. The result is compensatory hematopoietic expansion and impaired hepcidin production that causes increased intestinal iron absorption and progressive iron overload. Chronic hemolysis and red blood cell transfusions also contribute to iron tissue deposition. A better understanding of the underlying mechanisms led to the detection

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Islam, Sufia, Nazia Hoque, Nishat Nasrin, Mehnaz Hossain, Farhana Rizwan, Kushal Biswas, Muhammad Asaduzzaman, et al. "Iron Overload and Breast Cancer: Iron Chelation as a Potential Therapeutic Approach." Life 12, no. 7 (June 27, 2022): 963. http://dx.doi.org/10.3390/life12070963.

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Breast cancer has historically been one of the leading causes of death for women worldwide. As of 2020, breast cancer was reported to have overtaken lung cancer as the most common type of cancer globally, representing an estimated 11.3% of all cancer diagnoses. A multidisciplinary approach is taken for the diagnosis and treatment of breast cancer that includes conventional and targeted treatments. However, current therapeutic approaches to treating breast cancer have limitations, necessitating the search for new treatment options. Cancer cells require adequate iron for their continuous and rap

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Casu, Carla, and Stefano Rivella. "Iron age: novel targets for iron overload." Hematology 2014, no. 1 (December 5, 2014): 216–21. http://dx.doi.org/10.1182/asheducation-2014.1.216.

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Abstract Excess iron deposition in vital organs is the main cause of morbidity and mortality in patients affected by β-thalassemia and hereditary hemochromatosis. In both disorders, inappropriately low levels of the liver hormone hepcidin are responsible for the increased iron absorption, leading to toxic iron accumulation in many organs. Several studies have shown that targeting iron absorption could be beneficial in reducing or preventing iron overload in these 2 disorders, with promising preclinical data. New approaches target Tmprss6, the main suppressor of hepcidin expression, or use mini

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Sohn, Yang-Sung, William Breuer, Arnold Munnich, and Z. Ioav Cabantchik. "Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications." Blood 111, no. 3 (February 1, 2008): 1690–99. http://dx.doi.org/10.1182/blood-2007-07-102335.

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AbstractVarious pathologies are characterized by the accumulation of toxic iron in cell compartments. In anemia of chronic disease, iron is withheld by macrophages, leaving extracellular fluids iron-depleted. In Friedreich ataxia, iron levels rise in the mitochondria of excitable cells but decrease in the cytosol. We explored the possibility of using deferiprone, a membrane-permeant iron chelator in clinical use, to capture labile iron accumulated in specific organelles of cardiomyocytes and macrophages and convey it to other locations for physiologic reuse. Deferiprone's capacity for shuttlin

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Torshin, I. Yu, and O. A. Gromova. "Worldwide experience of the therapeutic use of the human placental hydrolytes." Experimental and Clinical Gastroenterology 1, no. 10 (March 2, 2020): 79–89. http://dx.doi.org/10.31146/1682-8658-ecg-170-10-79-89.

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Here we present the results of a systematic analysis of publications on the clinical and the experimental pharmacology of human placental hydrolyzates (HPH). Searches were performed in the PUBMED, ELIBRARY and RSL databases. The results of the analyses of the peptide composition of HPH allowed us to formulate a number of previously unknown molecular mechanisms of their action. In the article we examine the effects of HPH in the therapy of liver diseases, atopic dermatitis, herpetic infection, viral hepatitis, joint diseases, iron overload, chronic fatigue syndrome and consider the general rege

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Scott, Cassidy, Gaurav Arora, Kayle Dickson, and Christian Lehmann. "Iron Chelation in Local Infection." Molecules 26, no. 1 (January 2, 2021): 189. http://dx.doi.org/10.3390/molecules26010189.

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Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This physiological regulation represents the rationale for the therapeutic use of iron chelators to support induced iron deprivation and to treat infections. In this review paper we discuss the importance of iron regulation through examples of local infection and the potential of iron chelation in treating

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Moscheo, Carla, Elisa Fenizia, Mariaclaudia Meli, and Giovanna Russo. "Anemia sideropenica in età pediatrica: pillole di… ferro." QUADERNI ACP 28, no. 4 (2021): 173. http://dx.doi.org/10.53141/qacp.2021.176-180.

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Iron deficiency anemia is the most frequent haematological disorder in children. Although much is already known about the diagnostic-therapeutic approach, new frontiers regarding its diagnosis and therapeutic options emerge every day. An adequate intake with the diet is essential and can also be obtained in compliance with vegetarian-type diets. The use of glycinate or lysosomal preparations could positively affect the efficacy of therapy reducing the side effects associated with commonly used iron preparations. Parenteral iron therapy in pediatric age, which is currently limited to selected c

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James, Genevieve, Kevin Stephenson, Meghan Callaghan-Gillespie, Mohamed Tabita Kamara, Hui Gyu Park, J. Thomas Brenna, and Mark J. Manary. "Docosahexaenoic Acid Stability in Ready-to-Use Therapeutic Food." Foods 12, no. 2 (January 9, 2023): 308. http://dx.doi.org/10.3390/foods12020308.

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Ready-to-use therapeutic food (RUTF) is used to treat young children diagnosed with severe acute malnutrition. RUTF with low and balanced linoleic and alpha-linolenic acid, plus omega-3 docosahexaenoic acid (DHA), supports long-term cognitive recovery. DHA is prone to degradation due to peroxidation, possibly exacerbated by the iron inherently in RUTF. Our goals were to prepare benchtop and manufacturing scale of RUTF formulations that include DHA and measure its retention. Twenty-seven RUTF formulas with base ingredients, including oats, high oleic or commodity peanuts, and encapsulated or oi

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Bohn, Gunther, Sven Bayer, M. Stolz, Ansgar Ackva, and Bernhard Arndt. "Lifetime Simulation of Rechargeable Batteries for Solar Powered Fishing Lights." Applied Mechanics and Materials 848 (July 2016): 115–18. http://dx.doi.org/10.4028/www.scientific.net/amm.848.115.

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In the developing world artisanal fishermen use kerosene lanterns for night fishing. Solar powered fishing lights became an ecologic and economic alternative to the kerosene lanterns due to the development of high efficiency LED light sources and low price solar cells. In the last years several solar fishing light systems were developed. The choice of the battery technology influences the reliability and the operating cost of the fishing light, because the battery has the lowest lifetime of all components of the fishing light.In this paper we describe the results of a battery simulation over 5

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Kale, Pramodini B., Grant E. Sklar, Laurie A. Wesolowicz, and Ralph E. DiLisio. "Fluosol: Therapeutic Failure in severe Anemia." Annals of Pharmacotherapy 27, no. 12 (December 1993): 1452–54. http://dx.doi.org/10.1177/106002809302701206.

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OBJECTIVE: To report the use of Fluosol in the management of a severe anemia and to review the literature regarding the use of Fluosol. CASE REPORT: A 40-year-old woman, at 40.5 weeks gestation, was admitted for induction of labor. Her hospital course was complicated by a postpartum hemorrhage and severe anemia. Because the patient was a Jehovah's Witness, she received non-blood products including hetastarch, iron dextran, and erythropoietin, and a total of 33 mL/kg of Fluosol, but she did not survive. DISCUSSION: Fluosol is an oxygen-carrying, perfluorochemical blood substitute. It was admini

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Noor, Ramadhani A., Ajibola I. Abioye, Anne Marie Darling, Ellen Hertzmark, Said Aboud, Zulfiqarali Premji, Ferdinand M. Mugusi, et al. "Prenatal Zinc and Vitamin A Reduce the Benefit of Iron on Maternal Hematologic and Micronutrient Status at Delivery in Tanzania." Journal of Nutrition 150, no. 2 (October 16, 2019): 240–48. http://dx.doi.org/10.1093/jn/nxz242.

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ABSTRACT Background Zinc and vitamin A supplementation have both been shown to affect iron status, hemoglobin (Hb) concentration, and anemia in animal and human studies. However, evidence on their combined use in pregnancy, in the context of iron–folic acid (IFA) supplementation, remains limited. Objective This study determined the effects of prenatal zinc, vitamin A, and iron supplementation on maternal hematologic and micronutrient status at delivery in Tanzania. Methods We analyzed 2 large randomized controlled trials, using generalized estimating equations, and examined the effect of daily

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Haile, Zelalem T., Caroline Kingori, Asli K. Teweldeberhan, and Bhakti Chavan. "The relationship between history of hormonal contraceptive use and iron status among women in Tanzania: A population-based study." Sexual & Reproductive Healthcare 13 (October 2017): 97–102. http://dx.doi.org/10.1016/j.srhc.2017.07.003.

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Latham, Michael C., Deborah M. Ash, Diklar Makola, Simon R. Tatala, Godwin D. Ndossi, and Haile Mehansho. "Efficacy Trials of a Micronutrient Dietary Supplement in Schoolchildren and Pregnant Women in Tanzania." Food and Nutrition Bulletin 24, no. 4_suppl_1 (January 2003): S120—S128. http://dx.doi.org/10.1177/15648265030244s109.

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Traditionally, the main strategies used to control micronutrient deficiencies have been food diversification, consumption of medicinal supplements, and food fortification. In Tanzania, we conducted efficacy trials using a dietary supplement as a fourth approach. These were randomized, double-blind, placebo-controlled efficacy trials conducted separately first in children and later in pregnant women. The dietary supplement was a powder used to prepare an orange-flavored beverage. In the school trial, children consumed 25 g per school day attended. In the pregnancy trial, women consumed the cont

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Rathi, C. R., and S. N. Suresh. "Mirabilis jalapa Flower Extract as Therapeutic Agent and Cellular Delivery by Nanoparticles." Journal of Drug Delivery and Therapeutics 11, no. 1-s (February 15, 2021): 53–56. http://dx.doi.org/10.22270/jddt.v11i1-s.4549.

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Bio friendly green modest syntheses of nanoparticles are the present research in the extremity of nanotechnology. This study has been undertaken to explore the determinants of iron nanoparticles from 1 mM FeSO4 solution through profuse concentration of aqueous flower extract of Mirabilis jalapa reducing besides immobilizing agent. The attribute of iron nanoparticles was studied by using UV-VIS spectroscopy SEM and XRD. The XRD spectrum of the iron nanoparticles established the presence of elemental copper signal. Green synthesized iron nanoparticle manifests the zone of inhibition against isol

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Kochneva, E. V. "Analysis of the WHO guidelines on use of serum ferritin concentrations to assess iron status from the positions of 5-P medicine." Voprosy dietologii 10, no. 3 (2020): 15–22. http://dx.doi.org/10.20953/2224-5448-2020-3-15-22.

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According to the World Health Organization statistics, iron deficiency is among 10 most dangerous risk factors of developing various diseases, disability, and mortality throughout the world. Therefore, a correct determination of iron status in clinical practice is of decisive importance for diagnosis and screening in order to work out preventive and therapeutic measures. The new WHO guidelines emphasize the significance of monitoring the levels of ferritin, and also of serum iron, haemoglobin, transferrin, transferrin saturation, and inflammatory index in order to correctly assess iron status.

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Ning, Shuoyan, and Michelle P. Zeller. "Management of iron deficiency." Hematology 2019, no. 1 (December 6, 2019): 315–22. http://dx.doi.org/10.1182/hematology.2019000034.

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AbstractIron deficiency (ID) affects billions of people worldwide and remains the leading cause of anemia with significant negative impacts on health. Our approach to ID and iron deficiency anemia (IDA) involves three steps (I3): (1) identification of ID/IDA, (2) investigation of and management of the underlying etiology of ID, and (3) iron repletion. Iron repletion options include oral and intravenous (IV) iron formulations. Oral iron remains a therapeutic option for the treatment of ID in stable patients, but there are many populations for whom IV iron is more effective. Therefore, IV iron s

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Kurilovich, E. O., O. I. Volkova, and L. D. Popovich. "Clinical and economic aspects of the use of parenteral iron preparations for the correction of iron deficiency and anemia in surgical patients." Glavvrač (Chief Medical Officer), no. 12 (December 1, 2020): 44–54. http://dx.doi.org/10.33920/med-03-2012-04.

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The cost effectiveness of two groups of parenteral preparations (ferric sucrose complexes and ferric carboxymaltosate) for preoperative correction of iron deficiency/anemia in different organizational conditions was evaluated using pharmacoeconomic analysis with modeling elements. It is shown that the introduction of high doses of iron with a small number of infusions in the case of ferric carboxymaltosate is more cost-effective for all departments of medical institutions: in comparison with ferric sucrose complexes, the costs of a day hospital are reduced by 1.4 times, and the therapeutic and

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Kontoghiorghes, George J., Annita Kolnagou, Christina N. Kontoghiorghe, Loukia Mourouzidis, Viktor A. Timoshnikov, and Nikolay E. Polyakov. "Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications." Medicines 7, no. 8 (July 30, 2020): 45. http://dx.doi.org/10.3390/medicines7080045.

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Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and development of humans, and their deficiency can result in serious diseases. Their interaction is of nutritional, physiological, pharmacological and toxicological interest, with major implications in health and disease. Millions of people are using pharmaceutical and nutraceutical preparations of these two nutrients, including ferrous ascorbate for the treatment of iron deficiency anaemia and ascorbate combination with deferoxamine for increasing iron excretion in iron overload. The main function and use of vit

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Begum, Sartaz, Derick R. Mwakimbwala, Gideon Sangiwa, and Valence M. K. Ndesendo. "Chemical Analysis, Antibacterial Activities and Uses of Leaves and Calyces of Hibiscus sabdariffa Grown in Dodoma, Tanzania." Tanzania Journal of Science 48, no. 4 (December 30, 2022): 785–92. http://dx.doi.org/10.4314/tjs.v48i4.6.

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Preliminary phytochemical screening of aqueous and ethanolic extracts of Hibiscus sabdariffa grown in Tanzania revealed the presence of secondary metabolites like steroids, tannins, saponins, glycosides, terpenoids, flavonoids along with L-ascorbic acid (vitamin C) and iron(II). Furthermore, both leaves and calyces showed antibacterial activities (agar well diffusion method) against selected bacterial species (Escherichia coli, Staphylococcus aureus, Salmonella typhi and Shigella sonnei), but calyces possessed potent antibacterial activities compared to leaves. The results also supported the c

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Budnevsky, A. V., V. M. Provotorov, and Marina I. Ul’yanova. "Chronic obstructive pulmonary disease and anemia: clinical manifestations and therapeutic strategy." Clinical Medicine (Russian Journal) 94, no. 9 (November 2, 2016): 677–83. http://dx.doi.org/10.18821/0023-2149-2016-94-9-677-683.

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Anemia refers to manifestations of systemic infl ammation in chronic obstructive pulmonary disease (COPD) and a factor aggravating the disease. Objective: to study gender characteristics of anemia in patients with COPD, to increase the effectiveness of treatment through the use of pharmacological agents erythropoietin and enteral iron. Materials and methods. The paper presents clinical data on 74 patients with stage II/III COPD and anemiaalong with results of the treatment of 49 patients who received standard therapy in addition to epoetin and Sorbiferdurules. Results. Patients with COPD much

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Agoro, Rafiou, and Catherine Mura. "Iron Supplementation Therapy, A Friend and Foe of Mycobacterial Infections?" Pharmaceuticals 12, no. 2 (May 17, 2019): 75. http://dx.doi.org/10.3390/ph12020075.

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Iron is an essential element that is required for oxygen transfer, redox, and metabolic activities in mammals and bacteria. Mycobacteria, some of the most prevalent infectious agents in the world, require iron as growth factor. Mycobacterial-infected hosts set up a series of defense mechanisms, including systemic iron restriction and cellular iron distribution, whereas mycobacteria have developed sophisticated strategies to acquire iron from their hosts and to protect themselves from iron’s harmful effects. Therefore, it is assumed that host iron and iron-binding proteins, and natural or synth

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Wall, Erika, and Lauren Bolster. "Review of Therapeutic Erythrocytapheresis in Patients with Thalassemia Major." Blood 134, Supplement_1 (November 13, 2019): 1176. http://dx.doi.org/10.1182/blood-2019-126809.

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Introduction Therapeutic erythrocytapheresis, or red cell exchange (RCE) is a non-invasive procedure in which a patient's erythrocytes are removed from the bloodstream while being replaced with erythrocytes from blood donors. RCE is commonly used as a transfusion technique in patients with sickle cell disease (SCD) to help treat and prevent complications associated with sickling of erythrocytes and iron overload. In the rare blood disorders (RBD) clinic at the University of Alberta in Edmonton, Canada, RCE has been utilized as a therapeutic adjunct to traditional chelation therapies for patien

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Avramovich-Tirosh, Yael, Tamar Amit, Orit Bar-Am, Orly Weinreb та Moussa BH Youdim. "Physiological and pathological aspects of Aβ in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators". BMC Neuroscience 9, Suppl 2 (2008): S2. http://dx.doi.org/10.1186/1471-2202-9-s2-s2.

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O'Shea, Aileen, Anushri Parakh, Rita Maria Lahoud, Sandeep Hedgire, and Mukesh G. Harisinghani. "The Evolution of Iron Oxide Nanoparticles as MRI Contrast Agents." MRS Advances 5, no. 42 (2020): 2157–68. http://dx.doi.org/10.1557/adv.2020.311.

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AbstractWhile the use of iron oxide nanoparticles as magnetic resonance contrast agents for clinical imaging is established, they are more recently experiencing renewed interest as alternatives to gadolinium-based contrast agents. Ultra-small iron oxide nanoparticles have unique pharmacokinetics, metabolic and imaging properties. These properties have led to improved techniques for imaging a variety of vascular, oncologic and inflammatory conditions with iron oxide nanoparticles. Current research efforts are aimed at harnessing the characteristics of these nanoparticles to advance magnetic res

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Lima, Tadeu Gonçalves de, Fernanda Luna Neri Benevides, Flávio Lima Esmeraldo Filho, Igor Silva Farias, Diovana Ximenes Cavalcante Dourado, Eveline Gadelha Pereira Fontenele, Maria Elisabete Amaral de Moraes, and Ana Rosa Pinto Quidute. "Treatment of iron overload syndrome: a general review." Revista da Associação Médica Brasileira 65, no. 9 (September 2019): 1216–22. http://dx.doi.org/10.1590/1806-9282.65.9.1216.

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SUMMARY INTRODUCTION Iron overload is a broad syndrome with a large spectrum of causative etiologies that lead to iron deposition. When iron exceeds defenses, it causes oxidative damage and tissular disfunction. Treatment may prevent organ dysfunction, leading to greater life expectancy. METHODS Literature from the last five years was reviewed through the use of the PubMed database in search of treatment strategies. DISCUSSION Different pharmacological and non-pharmacological strategies are available for the treatment of iron overload and must be used according to etiology and patient complian

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Fontes de Paula Aguiar, Marina, Javier Bustamante Mamani, Taylla Klei Felix, Rafael Ferreira dos Reis, Helio Rodrigues da Silva, Leopoldo Penteado Nucci, Mariana Penteado Nucci-da-Silva, and Lionel Fernel Gamarra. "Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma." Nanotechnology Reviews 6, no. 5 (October 26, 2017): 449–72. http://dx.doi.org/10.1515/ntrev-2016-0101.

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AbstractThe purpose of this study was to review the use of the magnetic targeting technique, characterized by magnetic driving compounds based on superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery for a specific brain locus in gliomas. We reviewed a process mediated by the application of an external static magnetic field for targeting SPIONs in gliomas. A search of PubMed, Cochrane Library, Scopus, and Web of Science databases identified 228 studies, 23 of which were selected based on inclusion criteria and predetermined exclusion criteria. The articles were analyzed by phys

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Cahill, Catherine M., Rozaleen Aleyadeh, Jin Gao, Changning Wang, and Jack T. Rogers. "Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson’s Disease and Potential Therapeutic Role of 5’ Untranslated Region-Directed Small Molecules." Biomolecules 10, no. 10 (October 21, 2020): 1465. http://dx.doi.org/10.3390/biom10101465.

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Alpha-synuclein (α-Syn) is a 140-amino acid (aa) protein encoded by the Synuclein alpha SNCA gene. It is the synaptic protein associated with Parkinson’s disease (PD) and is the most highly expressed protein in the Lewy bodies associated with PD and other alpha synucleopathies, including Lewy body dementia (LBD) and multiple system atrophy (MSA). Iron deposits are present in the core of Lewy bodies, and there are reports suggesting that divalent metal ions including Cu2+ and Fe2+ enhance the aggregation of α-Syn. Differential expression of α-Syn is associated with alcohol use disorder (AUD), a

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Suciu, Maria, Corina M. Ionescu, Alexandra Ciorita, Septimiu C. Tripon, Dragos Nica, Hani Al-Salami, and Lucian Barbu-Tudoran. "Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements." Beilstein Journal of Nanotechnology 11 (July 27, 2020): 1092–109. http://dx.doi.org/10.3762/bjnano.11.94.

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Superparamagnetic iron oxide nanoparticles (SPIONs) have unique properties with regard to biological and medical applications. SPIONs have been used in clinical settings although their safety of use remains unclear due to the great differences in their structure and in intra- and inter-patient absorption and response. This review addresses potential applications of SPIONs in vitro (formulations), ex vivo (in biological cells and tissues) and in vivo (preclinical animal models), as well as potential biomedical applications in the context of drug targeting, disease treatment and therapeutic effi

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Messa, Emanuela, Daniela Cilloni, and Giuseppe Saglio. "Iron Chelation Therapy in Myelodysplastic Syndromes." Advances in Hematology 2010 (2010): 1–8. http://dx.doi.org/10.1155/2010/756289.

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Myelodysplastic syndromes (MDS) are a heterogeneous disorder of the hematopoietic stem cells, frequently characterized by anemia and transfusion dependency. In low-risk patients, transfusion dependency can be long lasting, leading to iron overload. Iron chelation therapy may be a therapeutic option for these patients, especially since the approval of oral iron chelators, which are easier to use and better accepted by the patients. The usefulness of iron chelation in MDS patients is still under debate, mainly because of the lack of solid prospective clinical trials that should take place in the

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Kimera, Zuhura I., Gasto Frumence, Leonard E. G. Mboera, Mark Rweyemamu, Stephen E. Mshana, and Mecky I. N. Matee. "Assessment of Drivers of Antimicrobial Use and Resistance in Poultry and Domestic Pig Farming in the Msimbazi River Basin in Tanzania." Antibiotics 9, no. 12 (November 24, 2020): 838. http://dx.doi.org/10.3390/antibiotics9120838.

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Uncontrolled use of drugs both in humans and animals coupled with environmental contamination exacerbate the development and spread of antimicrobial resistance. This paper assessed the drivers of antimicrobial use and resistance in poultry and domestic pig farming and the environment. Questionnaires, in-depth interviews, and focus group discussions (FGDs) were used to collect information regarding demographic characteristics, knowledge, practices, attitudes, and perceptions of the drivers of antimicrobial use and resistance in animal farming and the environment. We found a higher proportion of

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Cooke, Keegan S., Beth Hinkle, Hossein Salimi-Moosavi, Ian Foltz, Chadwick King, Palaniswami Rathanaswami, Aaron Winters, et al. "A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates." Blood 122, no. 17 (October 24, 2013): 3054–61. http://dx.doi.org/10.1182/blood-2013-06-505792.

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Key Points Fully human anti-hepcidin Abs have been generated for use as a potential therapeutic to treat AI. The mechanism of action was shown to be due to an increase in available serum iron leading to enhanced red cell hemoglobinization.

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Radzinsky, V. E., A. V. Solovyeva, and N. G. Fedotov. "The Anemia Syndrome in Contemporary Women: an Unsolved Worldwide Problem. A Therapeutic Approach." Doctor.Ru 19, no. 8 (2020): 20–24. http://dx.doi.org/10.31550/1727-2378-2020-19-8-20-24.

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Objective of the Review: To set forth the frequency and prevalence of the anemia syndrome in non-pregnant and pregnant women and approaches to treating this disorder. Key Points: Anemia syndrome is the most common health problem in contemporary women. The leading cause of iron deficiency in women of reproductive age is abnormal uterine bleeding (AUB). Anemia in women significantly reduces their ability to work and quality of life, and increases the rates and severity of complications in pregnant women and parturients. It is also a significant contributor to maternal mortality and fetal and neo

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Carmo, Wander Barros do, Bárbara Bruna Abreu Castro, Luísa Cardoso Manso, Priscylla Aparecida Vieira do Carmo, Clóvis Antônio Rodrigues, Melani Ribeiro Custódio, Vanda Jorgetti, and Helady Sanders-Pinheiro. "Iron-based phosphorus chelator: Risk of iron deposition and action on bone metabolism in uremic rats." Experimental Biology and Medicine 247, no. 5 (December 3, 2021): 446–52. http://dx.doi.org/10.1177/15353702211057280.

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Phosphate chelators are frequently used in patients with chronic kidney disease (CKD). New iron-based chelators remain understudied and offer a promising therapeutic option for the control of bone and mineral disorders of chronic kidney disease (BMD-CKD). We assessed the effect of the phosphorus chelator, chitosan-iron III (CH-FeCl), compared to calcium carbonate (CaCO3) in BMD-CKD and the potential iron overload in uremic rats. Thirty-two animals were divided into four groups, namely the control, CKD, CKD/CH-FeCl, and CKD/CaCO3 groups. CKD was induced by adding 0.75% (4 weeks) and 0.1% (3 wee

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Rivas-García, Lorenzo, José Luis Quiles, Alfonso Varela-López, Francesca Giampieri, Maurizio Battino, Jörg Bettmer, María Montes-Bayón, Juan Llopis, and Cristina Sánchez-González. "Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration." Pharmaceutics 13, no. 1 (January 12, 2021): 90. http://dx.doi.org/10.3390/pharmaceutics13010090.

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The application of metallic nanoparticles (materials with size at least in one dimension ranging from 1 to 100 nm) as a new therapeutic tool will improve the diagnosis and treatment of diseases. The mitochondria could be a therapeutic target to treat pathologies whose origin lies in mitochondrial dysfunctions or whose progression is dependent on mitochondrial function. We aimed to study the subcellular distribution of 2–4 nm iron nanoparticles and its effect on mitochondrial DNA (mtDNA), mitochondrial function, and autophagy in colorectal cell lines (HT-29). Results showed that when cells were

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Ward, Roberta J., David T. Dexter, Antonio Martin-Bastida, and Robert R. Crichton. "Is Chelation Therapy a Potential Treatment for Parkinson’s Disease?" International Journal of Molecular Sciences 22, no. 7 (March 24, 2021): 3338. http://dx.doi.org/10.3390/ijms22073338.

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Iron loading in some brain regions occurs in Parkinson’s Disease (PD), and it has been considered that its removal by iron chelators could be an appropriate therapeutic approach. Since neuroinflammation with microgliosis is also a common feature of PD, it is possible that iron is sequestered within cells as a result of the “anaemia of chronic disease” and remains unavailable to the chelator. In this review, the extent of neuroinflammation in PD is discussed together with the role played by glia cells, specifically microglia and astrocytes, in controlling iron metabolism during inflammation, to

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Talluri, Sekhar, and Rama R. Malla. "Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Diagnosis and Treatment of Breast, Ovarian and Cervical Cancers." Current Drug Metabolism 20, no. 12 (January 20, 2020): 942–45. http://dx.doi.org/10.2174/1389200220666191016124958.

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Background: The potential of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) as theranostic agents for cancer has been investigated extensively. SPIONS can be utilized for diagnostic imaging, drug delivery as well as for therapeutic applications. SPIONS are of particular interest because of their potential for non-invasive diagnosis and non-invasive therapeutic applications. This article is a review of in vivo and clinical studies of SPIONs for diagnosis and treatment of breast, ovarian and cervical cancer. The current limitations of this technology with relation to clinical therapeutic a

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Кorshikova, Yulia Ivanovna. "Iron deficiency anaemia due to constitutional menorrhagia as a risk factor of infectious and inflammatory diseases and use of phytotherapeutic medicines for its treatment." Vrač skoroj pomoŝi (Emergency Doctor), no. 8 (August 1, 2020): 51–59. http://dx.doi.org/10.33920/med-02-2008-03.

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The article presents clinical observations proving the importance of constitutional menorrhagia in the iron-deficiency anaemia genesis and a decrease in nonspecific resistance in women of childbearing age, as well as relevant use of phytotherapy method as a therapeutic and prophylactic agent.

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Hertrampf and Olivares. "Iron Amino Acid Chelates." International Journal for Vitamin and Nutrition Research 74, no. 6 (November 1, 2004): 435–43. http://dx.doi.org/10.1024/0300-9831.74.6.435.

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Iron amino acid chelates, such as iron glycinate chelates, have been developed to be used as food fortificants and therapeutic agents in the prevention and treatment of iron deficiency anemia. Ferrous bis-glycine chelate (FeBC), ferric tris-glycine chelate, ferric glycinate, and ferrous bis-glycinate hydrochloride are available commercially. FeBC is the most studied and used form. Iron absorption from FeBC is affected by enhancers and inhibitors of iron absorption, but to a lesser extent than ferrous sulfate. Its absorption is regulated by iron stores. FeBC is better absorbed from milk, wheat,

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Kroot, Joyce JC, Harold Tjalsma, Robert E. Fleming, and Dorine W. Swinkels. "Hepcidin in Human Iron Disorders: Diagnostic Implications." Clinical Chemistry 57, no. 12 (December 1, 2011): 1650–69. http://dx.doi.org/10.1373/clinchem.2009.140053.

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BACKGROUND The peptide hormone hepcidin plays a central role in regulating dietary iron absorption and body iron distribution. Many human diseases are associated with alterations in hepcidin concentrations. The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected. CONTENT We describe hepcidin structure, kinetics, function, and regulation. We moreover explore the therapeutic potential for modulating hepcidin expression and the diagnostic potential for hepcidin measurements in clinica

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Sharma, Shalini, Nisha Lamichhane, Parul, Tapas Sen, and Indrajit Roy. "Iron oxide nanoparticles conjugated with organic optical probes for in vivo diagnostic and therapeutic applications." Nanomedicine 16, no. 11 (May 2021): 943–62. http://dx.doi.org/10.2217/nnm-2020-0442.

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The role and scope of functional inorganic nanoparticles in biomedical research is well established. Among these, iron oxide nanoparticles (IONPs) have gained maximum attention as they can provide targeting, imaging and therapeutic capabilities. Furthermore, incorporation of organic optical probes with IONPs can significantly enhance the scope and viability of their biomedical applications. Combination of two or more such applications renders multimodality in nanoparticles, which can be exploited to obtain synergistic benefits in disease detection and therapy viz theranostics, which is a key t

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Ceci, Adriana, Laura Mangiarini, Mariagrazia Felisi, Franco Bartoloni, Angela Ciancio, Marcello Capra, Domenico D'Ascola, Paolo Cianciulli, and Aldo Filosa. "The Management of Iron Chelation Therapy: Preliminary Data from a National Registry of Thalassaemic Patients." Anemia 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/435683.

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Thalassaemia and other haemoglobinopathies constitute an important health problem in Mediterranean countries, placing a tremendous emotional, psychological, and economic burden on their National Health systems. The development of new chelators in the most recent years had a major impact on the treatment of thalassaemia and on the quality of life of thalassaemic patients. A new initiative was promoted by the Italian Ministry of Health, establishing a Registry for thalassaemic patients to serve as a tool for the development of cost-effective diagnostic and therapeutic approaches and for the defi

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Elias, Andrew, and Andrew Tsourkas. "Imaging circulating cells and lymphoid tissues with iron oxide nanoparticles." Hematology 2009, no. 1 (January 1, 2009): 720–26. http://dx.doi.org/10.1182/asheducation-2009.1.720.

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Abstract The use of nanometer-sized iron oxide nanoparticles and micron-sized iron oxide particles as magnetic resonance (MR) contrast agents has garnered a high degree of interest in diverse areas of biology and medicine. Applications such as cell tracking, molecular imaging, gene detection, and lymphography are being explored to provide insight into disease mechanisms, monitor therapeutic efficacy, and facilitate diagnostic imaging. What makes iron oxide so appealing is a number of favorable properties including high detectability by MR, biodegradability and low toxicity. Here we describe th

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Arshad, Shumaila, Farah Abid, Hafiza Amina Aziz, Raffia Anjum, and Iram Nadeem. "Specific Poisons in Pakistan: A Mini Review." Research in Pharmacy and Health Sciences 2, no. 3 (August 15, 2016): 179–86. http://dx.doi.org/10.32463/rphs.2016.v02i03.36.

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Poisoning either results from intentional or unintentional exposures, recreational drug use, and therapeutic use of drugs or other agents. Although mortality and serious morbidity in poisonings are uncommon, patients requiring hospitalization often require intensive care. The appropriate management of poisoned patients should improve outcome and decrease complications. Some specific poisons in Pakistan are pesticides, hydrocarbons, iron, insecticides, benzodiazepines, organophosphates etc.

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Kisamo, Ombeni, Manase Kilonzi, Wigilya P. Mikomangwa, George M. Bwire, Hamu J. Mlyuka, Alphonce I. Marealle, and Ritah F. Mutagonda. "The magnitude of prescribing medicines by brand names at Muhimbili National Hospital, Tanzania." Medicine Access @ Point of Care 4 (January 2020): 239920261990014. http://dx.doi.org/10.1177/2399202619900148.

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Background: Tanzania National Treatment Guidelines and National Therapeutic Committee circular of 2012 requires prescribers to prescribe medicines using their generic names as recommended by the World Health Organization. The implementation of the aforementioned recommendations by prescribers is not well documented in our settings. Therefore, this study aimed to explore the compliance on the use of generic names by prescribers at Muhimbili National Hospital. Methods: A descriptive cross-sectional study was conducted at Muhimbili National Hospital from January to May 2019 in both inpatient and

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Lyoba, Winfrida B., Joyce D. Mwakatoga, Charles Festo, Jackline Mrema, and Ester Elisaria. "Adherence to Iron-Folic Acid Supplementation and Associated Factors among Pregnant Women in Kasulu Communities in North-Western Tanzania." International Journal of Reproductive Medicine 2020 (June 5, 2020): 1–11. http://dx.doi.org/10.1155/2020/3127245.

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Introduction. Pregnant women are at a high risk of anaemia, with iron-folate deficiency being the most common cause of anaemia among pregnant women. Despite the well-known importance of iron and folic acid supplementation (IFAS) during pregnancy, adherence to these supplements is relatively low and associated factors were not well identified in the study area. This study is aimed at investigating adherence to IFAS and associated factors among pregnant women in Kasulu district, north-western Tanzania. Methods. A health facility cross-sectional survey with a mixed-method approach was conducted i

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Toro-Urrego, Nicolas, Liliana F. Turner, and Marco F. Avila-Rodriguez. "New Insights into Oxidative Damage and Iron Associated Impairment in Traumatic Brain Injury." Current Pharmaceutical Design 25, no. 45 (January 10, 2020): 4737–46. http://dx.doi.org/10.2174/1381612825666191111153802.

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: Traumatic Brain Injury is considered one of the most prevalent causes of death around the world; more than seventy millions of individuals sustain the condition per year. The consequences of traumatic brain injury on brain tissue are complex and multifactorial, hence, the current palliative treatments are limited to improve patients’ quality of life. The subsequent hemorrhage caused by trauma and the ongoing oxidative process generated by biochemical disturbances in the in the brain tissue may increase iron levels and reactive oxygen species. The relationship between oxidative damage and the

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Gardenghi, Sara, Pedro Ramos, Cindy N. Roy, Nancy C. Andrews, Elizabeta Nemeth, Xiuli An, Mohandas Narla та ін. "Hepcidin as a Therapeutic Tool to Limit Iron Overload and Improve Anemia In β-Thalassemia". Blood 116, № 21 (19 листопада 2010): 1009. http://dx.doi.org/10.1182/blood.v116.21.1009.1009.

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Abstract Abstract 1009 The principal regulator of iron homeostasis, the hepatic peptide hepcidin (Hamp), degrades the iron-transport protein ferroportin (Fpn) localized on absorptive enterocytes, hepatocytes and macrophages. Low Hamp expression has been associated with iron overload in patients and mice affected by β-thalassemia intermedia (th3/+). Our hypothesis is that more iron is absorbed than required for erythropoiesis in β-thalassemia. Therefore, we propose that limiting the dietary iron intake of th3/+ mice either by feeding them a low iron diet or increasing their Hamp expression will

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