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Thematische Bibliographien / Light for bipolar disease / Dissertationen

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Dissertationen zum Thema „Light for bipolar disease“

Autor: Grafiati

Veröffentlicht am 25. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Svanberg, Mira. "The right light at the right time for bipolar patients. An exploratory study of light environments for patients with bipolar disease in behavioral health clinics." Thesis, KTH, Ljusdesign, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-297963.

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Research has showed that different light scenarios have a profound effect on hospitalized bipolar patients. Different light situations decrease the hospital stay for patients during both manic and depressive episodes. Nevertheless, a field study carried out during this thesis work of two arbitrary patient rooms in Swedish behavioral health clinics showed no incorporation of this knowledge in the light design of the rooms. Both patient rooms had insufficient light levels both in terms of circadian recommendations and perceived brightness. Hence this thesis suggests an improved light design for

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Hickey, Doron. "Optogenetic gene therapy for vision restoration : light-sensitive proteins, viral vectors and bipolar cell adaptation to a diseased state." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:820a45d5-60db-4c01-808a-8a3720c48f2c.

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Inherited retinal dystrophies are a heterogeneous group of retinal diseases that often lead to blindness. The diverse range of causative gene mutations poses great challenges to developing therapies to improve the vision of affected people. One technique being investigated is optogenetics for vision restoration, a technique that aims to deliver light-sensitising molecules to the affected retina. This research project provides data on a range of variables that need to be optimised in order to successfully restore vision using an optogenetic gene therapy approach. Fifteen wild type, chimeric and

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Quinn, Dale Edward Physics Australian Defence Force Academy UNSW. "Scattering of light by dust in bipolar outflow sources." Awarded by:University of New South Wales - Australian Defence Force Academy. School of Physics, 2001. http://handle.unsw.edu.au/1959.4/38687.

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Interstellar dust plays an important role in the physics of the interstellar medium, as well as the formation and evolution of stars. The presence of dust is often indicated in optical images by dark lanes which bisect spiral galaxies, or seen directly as reflection nebulosity around stars or emission nebulosity if sufficient heating is present. Of interest in this thesis is the dust that is associated with bipolar outflow sources. Bipolar outflows can occur in either evolved stars or in young stellar objects, and are so named because they consist of two lobes which are thought to be due to ou

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Beauchemin, Kathleen Mary. "Nocturnal psychopathology : sleep, dreaming, mood and light-therapy in bipolar disorder /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22949.pdf.

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5

Douman, Samantha Fiona. "Development of Highly Sensitive Electrochemiluminescence Platforms and Application in Disease Biomarker Immunosensing." University of the Western Cape, 2018. http://hdl.handle.net/11394/6238.

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Philosophiae Doctor - PhD (Chemistry)<br>Electrochemiluminescence (ECL) is a light-emitting process generated by electrochemical redox reactions and has been widely used as an analytical tool, especially in the field of biosensing, that is, immunoassays and DNA-probe assays. Thus, the scope of this work was to develop a simple, sensitive ECL immunosensor for cardiac injury and to study and present insights into newly fabricated platforms for bioanalytical applications by using ECL as detection mechanism.<br>2021-08-31

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Mazade, Reece Eric. "Modulation Of Inner Retinal Inhibition With Light Adaptation." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/565903.

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The retina is able to adjust its signaling over a wide range of light levels. A functional result of this is increased visual acuity at brighter luminance levels, such as during the day, due to changes in the organization of retinal receptive fields. This process is commonly referred to as light adaptation. These organizational changes have been shown to occur at the level of the ganglion cells, the output neurons of the retina, which have shifts in their excitatory center-inhibitory surround receptive fields that increase their sensitivity to small stimuli. Recent work supports the idea that

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7

Lee, Tik Ho. "Synthesis and characterization of electroluminescent bipolar small molecules and polymers." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/878.

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8

Madeira, A. C. A. "Growth, light interception and disease in field bean." Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384294.

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9

Duis, Christine Ann. "THE NEUROPSYCHOLOGICAL FUNCTIONING OF BIPOLAR DISORDER DURING MANIA AND RELATIONSHIP TO DEMOGRAPHIC AND DISEASE VARIABLES." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin990818739.

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10

Fiedorowicz, Jess G. "Course of illness and the development of vascular disease in individuals with bipolar disorder." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2699.

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For over a century, there have been suggestions of a link between what is currently called bipolar disorder and cardiovascular mortality. In the contemporary epidemiological literature, this risk has been confirmed and approximates twice that expected based on age and gender. To date, however, this information has come primarily from clinical samples, which carry considerable risk of selection bias. The studies contained in this dissertation sought to assess this relationship using methods less vulnerable to selection bias and to determine the role that course of illness and treatments for ill

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Proal, Amy. "Autoimmune disease re-examined in light of metagenomic concepts." Thesis, Proal, Amy (2012) Autoimmune disease re-examined in light of metagenomic concepts. PhD thesis, Murdoch University, 2012. https://researchrepository.murdoch.edu.au/id/eprint/8484/.

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The concept of autoantibodies was developed at a time when, due to the limitations of culturebased techniques, the human body was considered to be largely sterile. However, over the past few years, researchers in the emerging field of metagenomics have developed molecular tools that instead allow microbes to be identified by their genomic fingerprints. These tools have opened a door to an era of tremendous discovery. Homo sapiens has been shown to harbor thousands of species of microbes in tissue and blood that were previously undetectable. Today it is estimated that around 90% of the cells in

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Moore-Dotson, Johnnie M., Jamie J. Beckman, Reece E. Mazade, et al. "Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling." Association for Research in Vision and Ophthalmology (ARVO), 2016. http://hdl.handle.net/10150/604678.

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Recent studies suggest that the neural retinal response to light is compromised in diabetes. Electroretinogram studies suggest that the dim light retinal rod pathway is especially susceptible to diabetic damage. The purpose of this study was to determine whether diabetes alters rod pathway signaling.

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Wageck, Aline André Rodrigues. "Risco cardiovascular em pacientes com transtorno de humor bipolar." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/164356.

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O transtorno de humor bipolar (THB) é uma condição incapacitante e caracterizada pela presença de episódios de humor associados a alterações de cognição e de comportamento. Indivíduos com diagnóstico de THB estão particularmente propensos a múltiplas condições metabólicas. Em uma parcela dos pacientes acometidos pela doença observa-se a neuroprogressão do quadro, com alterações no campo da neuroimagem e de biomarcadores – citocinas inflamatórias, estresse oxidativo e neurotrofinas. Tais fatores parecem também relacionar-se ao aumento do risco cardiovascular (RCV) observado nessa população, vis

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Santos, Glenda Dias dos. "Transtorno bipolar e doença de Alzheimer em idosos: impacto na vida dos cuidadores." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-12062018-133552/.

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Os cuidadores são elementos essenciais na prestação dos cuidados de saúde, especialmente em situações de doenças crônicas e incapacitantes. Sobrecarga experimentada por cuidadores de pacientes com transtorno bipolar (TB) é pouco estudada em comparação a outras doenças, como a doença de Alzheimer (DA). O objetivo desse estudo é comparar a sobrecarga, desgaste emocional e os fatores associados em cuidadores de idosos com TB e DA. Trata-se de um estudo transversal, do tipo quanti-qualitativo, que avaliou 75 cuidadores e seus respectivos pacientes (36 com TB e 39 com DA). Para avaliação dos cuidad

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Gylfe, Åsa. "Role of birds in the biology of Lyme disease Borrelia." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118928.

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Lyme disease is a tick-transmitted illness caused by Borrelia burgdorferi sensu lato (s.l.), a group of spirochetes with at least three human pathogenic species, B. burgdorferi sensu stricto, B. afzelii and B. garinii. These spirochetes cycle between vertebrate reservoirs, mainly rodents, and ixodid ticks. Both terrestrial birds and seabirds can be infected with B. burgdorferi s.l. but the function of birds as reservoirs is largely unknown, even though they are potentially important epidemiologically due to their ability to carry ectoparasites and microorganisms over long distances. This thesi

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Basnayake, Kolitha Indika. "The biology of immunoglobulin free light chains in kidney disease : a study of Monoclonal and Polyclonal light chains." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/2862/.

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Monoclonal immunoglobulin free light chains (FLCs) cause a range of disorders in the kidney. In multiple myeloma, FLCs can activate the proximal tubule to release MCP-1, an important cytokine in renal fibrosis. Distal tubular cast formation can also occur when FLCs co-precipitate with uromodulin. However a pathogenic role for the elevated polyclonal FLC concentrations seen in chronic kidney disease has not been assessed to date. This thesis explores the biology of monoclonal FLCs as well as polyclonal FLCs. Detailed histological analyses demonstrated that in multiple myeloma, interstitial fibr

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Eklund, Rebecca. "”Hade jag inte haft den hade jag nog inte alls varit den jag är idag” : En kvalitativ studie om identitet hos människor med bipolär sjukdom." Thesis, Luleå tekniska universitet, Institutionen för ekonomi, teknik och samhälle, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-79955.

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Syftet med studien var att undersöka hur bipolär sjukdom kan påverka en människas identitet. Tidigare forskning har föreslagit att människor med bipolär sjukdom kan ha svårt att identifiera vem de verkligen är och att de kan ha en mindre utvecklad identitet. I denna kvalitativa studie genomfördes tio djupintervjuer som sedan kodades. En tematisk analys utfördes. Fyra teman identifierades: Uppfattning om identitet, acceptans, föräldraskap och sjukdomens påverkan på livet. En övervägande del av respondenterna uppgav att sjukdomen är en del av deras identitet, detta motsäger tidigare forskning.

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Ropelewski, Philip Edward. "Light-Independent Pathology of Rhodopsin Mislocalization." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586965687533716.

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Stone, Elizabeth J. "The Effect of Charcot-Marie-Tooth Disease Mutations in Neurofilament Light on Neurofilaments." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1585652615669143.

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20

Toepfer, Christopher. "The role of myosin regulatory light chain phosphorylation in cardiac health and disease." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/30846.

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In this thesis we examined the effect of myosin associated regulatory light chain (RLC) phosphorylation level on cardiac muscle, ensembles and single molecules. We measured the ability of RLC phosphorylation change in muscle to alter force, power and unloaded shortening. The ATPase rate of full length cardiac myosin was determined with a novel protocol using gelsolin capped actin, which allowed novel measurements of myosin ATPase with full length (filamentous) myosin in low ionic strength. Actin gliding assays determined the effects of RLC phosphorylation level on actin gliding velocities unde

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Nylk, Jonathan. "Advanced light-sheet and structured illumination microscopy techniques for neuroscience and disease diagnosis." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/10842.

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Optical microscopy is a cornerstone of biomedical research. Advances in optical techniques enable specific, high resolution, sterile, and biologically compatible imaging. In particular, beam shaping has been used to tailor microscopy techniques to enhance microscope performance. The aim of this Thesis is to investigate the use of novel beam shaping techniques in emerging optical microscopy methods, and to apply these methods in biomedicine. To overcome the challenges associated with high resolution imaging of large specimens, the use of Airy beams and related techniques are applied to light-sh

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Agresta, A. M. "PROTEOMIC INVESTIGATION ON NASU-HAKOLA DISEASE: SHEDDING LIGHT ON FRONTOTEMPORAL TREM2-BASED DEMENTIA." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/543128.

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La malattia di Nasu-Hakola (NHD), nota anche come osteodisplasia lipomembranosa policistica con leucoencefalopatia sclerosante (PLOSL), è una patologia sistemica ereditaria recessiva caratterizzata da demenza presenile frontotemporale e lesioni ossee. Le basi genetiche che determinano la patologia sono correlate ad un difetto strutturale di due geni, TREM2 e DAP12, che codificano per due subunità del recettore transmembrana di un complesso di segnalazione espresso dalle cellule della microglia e dagli osteoclasti. Ad oggi, studi molecolari o proteomici di questa malattia sono assenti o scarsi,

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Hobbs, Eleanor. "Investigation of candidate risk genes for neuropsychiatric disease in vitro and in vivo using ENU mutagenesis." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:6204220c-3680-4549-8399-872c6dd4b473.

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Schizophrenia is a complex mental disorder characterised by positive symptoms such as hallucinations and psychosis, negative symptoms such as avolition and anhedonia, and cognitive defects. Schizophrenia risk has a genetic component, and it is likely that this is caused by interaction between numerous genes with individually small effects. Environment also plays a role; factors associated with schizophrenia include drug use, prenatal stressors and living environment. Candidate genes linked to schizophrenia have been identified through recent GWAS of human populations with the disorder, includi

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Buervenich, Silvia. "Candidate genes and the dopamine system : possible implications in complex neurological and psychiatric disease /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-202-7.

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25

He, Xingyu. "Long-term Light-activated Drug Delivery Systems." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613752062550859.

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26

Lochner, Zachary M. "Heterojunction bipolar transistors and ultraviolet-light-emitting diodes based in the III-nitride material system grown by metalorganic chemical vapor deposition." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/49032.

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The material and device characteristics of InGaN/GaN heterojunction bipolar transistors (HBTs) grown by metalorganic chemical vapor deposition are examined. Two structures grown on sapphire with different p-InxGa1-xN base-region compositions, xIn = 0.03 and 0.05, are presented in a comparative study. In a second experiment, NpN-GaN/InGaN/GaN HBTs are grown and fabricated on free-standing GaN (FS-GaN) and sapphire substrates to investigate the effect of dislocations on III-nitride HBT epitaxial structures. The performance characteristics of HBTs on FS-GaN with a 20×20 m2 emitter area exhibit

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Ekström, Smedby Karin. "Ultraviolet light, autoimmune disorders and the etiology of malignant lymphomas /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-313-2/.

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Abdalla, Dulcineia Saes Parra. "Envolvimento de espécies ativas de oxigênio na esquizofrenia e psicose maníaco-depressiva." Universidade de São Paulo, 1988. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-24102007-143446/.

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Os mecanismos bioquímicos envolvidos na maioria das doenças psiquiátricas ainda não estão esclarecidos. Estudos recentes têm sugerido a participação de espécies ativas de oxigênio em diversas patologias. Baseados em informações pre liminares da literatura, propusemo-nos a investigar o possível envolvimento de radicais de oxigênio e enzimas antioxidantes na esquizofrenia e psicose maníaco-depressiva. A análise das atividades eritrocitárias da superóxido dismutase (SOD) e glutationa peroxidase (GSH-Px) nestes pacientes mostrou níveis significativamente elevados de SOD (cerca de 1,5 vezes) em re

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Bitsios, Panagiotis. "A psychophysiological and pharmacological investigation of the autonomic regulation of the pupil in man." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337277.

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30

Hofman, Pim. "Blood-ocular barriers in health and disease light and electron microscopic studies of the eye /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/58150.

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31

Dumpala, Sunila. "The role of retinal photoreceptors in the regulation of circadian rhythms and sleep in systemic disease." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/203959/1/Sunila_Dumpala_Thesis.pdf.

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Retinal photoreceptors provide light signals to regulate the pupil light reflex, circadian photoentrainment and sleep. People with either diabetes or Parkinson's disease experience circadian disruption, but the pathophysiology is not well understood. This thesis demonstrates that in diabetes, dysfunctional outer retinal rod inputs to melanopsin ganglion cells contribute to the sleep disruption. In Parkinson's disease, the dysfunction is at the level of melanopsin ganglion cells, with additional non-selective reductions in retinal contrast gain. These findings identify new retinal pathways cont

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Moore, Jill E. "Defining a Registry of Candidate Regulatory Elements to Interpret Disease Associated Genetic Variation." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/927.

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Over the last decade there has been a great effort to annotate noncoding regions of the genome, particularly those that regulate gene expression. These regulatory elements contain binding sites for transcription factors (TF), which interact with one another and transcriptional machinery to initiate, enhance, or repress gene expression. The Encyclopedia of DNA Elements (ENCODE) consortium has generated thousands of epigenomic datasets, such as DNase-seq and ChIP-seq experiments, with the goal of defining such regions. By integrating these assays, we developed the Registry of candidate Regulator

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Siddiq, Anjum Ara. "The control of sexual morphogenesis in Pyrenopeziza brassicae, cause of light leaf spot of brassicas." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330090.

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Doubal, Fergus Neil. "Do retinal microvascular abnormalities shed light on the pathophysiology of lacunar stroke?" Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5546.

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Background. Lacunar strokes account for 25% of all ischaemic stroke but the exact nature of the causative cerebral small vessel abnormality remains unknown. Pathological studies are technically difficult and brain imaging cannot adequately characterise the cerebral small vessels. The retinal blood vessels are of similar size and physiology to the cerebral small vessels and may act as a surrogate marker for these cerebral small vessels. We therefore investigated retinal microvascular abnormalities in lacunar stroke. Methods. We performed a systematic review of retinal microvascular abnormalitie

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Pfennig, Andrea, Karolina Leopold, Philipp Ritter, Anne Böhme, Emanuel Severus, and Michael Bauer. "Longitudinal changes in the antecedent and early manifest course of bipolar disorder—A narrative review of prospective studies." Sage, 2017. https://tud.qucosa.de/id/qucosa%3A35432.

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Objective: Prospective study designs ideally allow patients to be followed from the first manifestations of the illness or even from an at-risk stage. It can thus provide data on the predictive value of changes in clinical symptomatology, cognition or further biological markers to broaden our understanding of the etiopathology and symptomatic trajectory of bipolar disorders. The scope of this narrative review is to summarize evidence from prospectively collected data on psychopathological and other clinical and biological changes in the early developmental course of bipolar disorders. Methods

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Griggs, Henry G. "Potential iatrogenic effects on enamel treated with a light cured flouride releasing filled resin." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008m/griggs.pdf.

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Costa, Alana Caroline. "Determinação de fosfolípides plasmáticos nas doenças neuropsiquiátricas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-11092017-115142/.

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Os fosfolípides e moléculas relacionadas compreendem 60% da porção não aquosa do cérebro e são os principais constituintes das membranas de células neuronais e gliais. Os fosfolípides são essenciais para todas as células vivas e, portanto, mudanças no seu metabolismo podem influenciar o organismo. Alterações no metabolismo de fosfolípides estão envolvidas em inúmeras doenças neuropsiquiátricas incluindo a doença de Alzheimer, esquizofrenia e o transtorno bipolar. Neste trabalho, tivemos por objetivo compreender a composição lipídica de metabólitos relacionados à membrana de pacientes com difer

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Luk, Wai-ming Albert, and 陸偉明. "Association of light exposure intensity with the quality of sleep and behavioral symptoms in Chinese Alzheimer's disease patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/209551.

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Introduction: Dementia is an age-associated neurodegenerative disorder characterized by a progressive loss of neuro-cognitive function and the emergence of a wide variety of behavioral symptoms. Alzheimer's disease (AD) is the most common types of dementia. Sleep disturbances in patients with Alzheimer's disease is common and previous studies from North America, Europe and Japan reported light therapy could improve the sleep circadian rhythm ( rest-activity) disturbances in AD. However, there was no previous Chinese study on light exposure and sleep quality nor the circadian rhythm in Chines

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Kjellner, Emma, and Katrin Petersson. "Människors upplevelser av att leva med bipolär sjukdom : En analys av självbiografier." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16501.

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Bakgrund: Bipolär sjukdom är en psykisk sjukdom, sjukdomen utmärks av återkommande depressiva- och maniska perioder som påverkar upplevelser av människors livsvärld och hälsa. Sjuksköterskan har en betydande roll när personer med bipolär sjukdom är i kontakt med hälso-och sjukvården. För att öka förståelse kring upplevelser av att leva med bipolär sjukdom, behövs mer forskning. Syfte: Syfte är att belysa människors upplevelser av att leva med bipolär sjukdom. Metod: En kvalitativ metod användes. Narrativer i form av sex självbiografier analyserades, datamaterialet har analyserats utifrån Dahlb

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Barroso, Maria Clara Brasileiro. "Effects of exposure to light in the motor changes and not motor of Parkinson's disease: a randomized, placebo-controlled study." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13068.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Circadian abnormalities may contribute to sleep/wake alterations, cognitive and motor fluctuations in PD patients. The objective of this study is to test the effects of evening bright-light therapy on sleep disturbances, cognitive performance, disease severity and quality of life in PD patients. Patients with PD were randomized to bright-light therapy (10000 lux) or placebo (<500 lux) at evening. They were tested at baseline and after therapy with the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA), the Parkinsonâs Dis

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Aguilera, Matthieu. "The light at the end of the tunnel : study of early-stage brain dynamics alterations in Alzheimer’s disease and beneficial effects of light stimulation in the AppNL-F/MAPT mouse model." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ066.

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La maladie d’Alzheimer (MA), première cause de démence dans le monde, reste un défi majeur en raison de son diagnostic tardif et de l’absence de traitements efficaces. Alors que le diagnostic actuel repose sur la détection à travers des méthodes invasives de marqueurs pathologiques classiques tels que les plaques amyloïdes après l'apparition des symptômes cognitifs, de nombreuses études suggèrent que les changements pathologiques débutent des décennies avant ces manifestations cliniques. Le bon fonctionnement cérébral dépend d’une activité dynamique complexe, permettant des transitions flexibl

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Strath, Scott J. "The effect of a light-moderate versus hard exercise intensity on health and fitness benefits." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115726.

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The purpose of this study was to determine the effect of a light-moderate versus hard exercise intensity on health and fitness benefits in a previously sedentary population. Twenty-six subjects, 17 male (mean age 45 + 3 yrs), 9 female (mean age 48 + 3 yrs) with at least one coronary artery disease risk factor volunteered to participate in this study. Subjects underwent laboratory testing comprising of, resting heart rate and blood pressure, body composition, blood lipid analysis and aerobic capacity (V02 ), prior to and 22-32 weeks after participating > 2 days per week in the Adult Physical Fi

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Gigante, Alexandre Duarte. "Estudo do hipocampo de portadores de transtorno afetivo bipolar após o primeiro episódio de mania através do uso da espectroscopia por ressonância magnética de próton (1H-ERM)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-18122013-150223/.

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A investigação da fisiopatologia do transtorno bipolar em pacientes no início da doença é uma estratégia para evitar um potencial efeito de confusão associado à duração da doença, presença de múltiplos episódios de alteração do humor e tratamento medicamentoso. Nosso objetivo foi investigar, in vivo, metabólitos neuronais do hipocampo de portadores de transtorno afetivo bipolar (TAB) usando a espectroscopia por ressonância magnética de próton (1H-ERM) logo após o seu primeiro episódio de mania. Para isso, foram estudados cinqüenta e oito pacientes com TAB tipo I, classificados de acordo com os

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Nordin, Charlotta, and Persson Maria Höglund. "Upplevelser av att leva med en person med bipolär sjukdom ur ett familjeperspektiv : en litteraturstudie." Thesis, Umeå universitet, Institutionen för omvårdnad, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-132279.

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AbstraktTitel: Upplevelser av att leva med en person med bipolär sjukdom - ett familjeperspektiv – En litteraturstudie. Bakgrund: Psykisk ohälsa och sjukdom är idag så vanligt förekommande att det räknas som ett folkhälsoproblem, men det finns fortfarande fördomar och stigmatisering kvar kring bilden av psykisk ohälsa. Ofta är det närstående som vårdar sina psykiskt sjuka anhöriga och sjukvårdspersonal behöver bli bättre på att möta närstående i vården och ta tillvara på deras kompetens och kunskap. Inom psykiatrin har det visat sig att närstående fortfarande kan känna sig utanför och att de u

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Sandberg, Ulrika, and Niclas Lindén. "Det finns en människa bakom sjukdomen : En litteraturöversikt om personers upplevelser och erfarenheter av att leva med bipolär sjukdom." Thesis, Ersta Sköndal högskola, Institutionen för vårdvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-5265.

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Bakgrund: Bipolär sjukdom är vanlig i världen och det blir vanligare i Sverige att personer med sjukdomen söker vård, både inom öppenvården och slutenvården. Omvårdnaden riktar in sig på att stödja och vägleda i hantering av symptom och sjukdomstecken. Hälsoutbildning har visats kunna fördröja återinsjuknandet och en personcentrerad vårdplan likaså. Många med bipolär sjukdom är odiagnostiserade och sjuksköterskan har en viktig roll i att bidra till att uppmärksamma dessa, för att kunna ge en god omvårdnad. Syfte: Syftet var att belysa personers upplevelser och erfarenheter av att leva med bipo

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Paarmann, Kristin [Verfasser]. "The role of mitochondrial function and ABC transporters in healthy aging and Alzheimer's disease in the light of genetic modifications / Kristin Paarmann." Magdeburg : Universitätsbibliothek, 2017. http://d-nb.info/1162189959/34.

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CREMASCOLI, RICCARDO. "CIRCADIAN RHYTHM DYSFUNCTION IN ALZHEIMER’S DISEASE: HOW TO DETERMINE CIRCADIAN PHASE AND THE ROLE OF TAYLORED LIGHT THERAPY ON SLEEP AND COGNITION." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1371755.

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In this thesis circadian rhythm alterations in Alzheimer’s disease (AD) are taken into account, in particular concerning the early stage of disease. In the first part of this 3-year work the research was focused on determining the circadian phase in early AD patients using subjective and objective measures: clinical scales, sleep-wake diaries, salivary melatonin determination (DLMO), phase angles between sleep and melatonin onset. To achieved this goal we performed a case-control observational study comparing the circadian phase of early AD patients elderly healthy controls (Hc). The main resu

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Dhiman, Kunal. "Utility of CSF biomarkers for the diagnosis, prognosis and assessment of cognitive decline in Alzheimer’s disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2020. https://ro.ecu.edu.au/theses/2284.

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Alzheimer’s disease (AD) is a slow and progressive neurodegenerative disorder.With new treatment strategies failing in clinical trials, there is a need to initiate a targeted treatment strategy, by administering the right medication, to the right individual, at the right stage. This concept of precision medicine not only requires diagnosis at the preclinical stage, but a thorough understanding of the stage-associated neuropathological changes that occur along the continuum of AD. Pathophysiological biomarkers indicative of neuropathological changes in the brain are needed to identify the precl

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Stepczynski, Jadwiga Maja. "Defining the molecular phenotype of the rat retina during the commitment phase of light-induced retinal degeneration, a model of human retinal degenerative disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ60502.pdf.

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Grillo, Giacomo. "The ICF syndrome and emergent players in DNA methylation and development : when studying a rare genetic disease sheds new light on an "old" field." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC300/document.

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La méthylation de l'ADN est un processus vital pour le développement des mammifères. Sa distribution anormale,notamment au niveau des régions répétées du génome, est une signature pathologique. La découverte de maladies héréditaires touchant la stabilité du génome a permis des avancées considérables dans l'identification des acteurs et des mécanismes. Nous avons choisi d'étudier le syndrome ICF (Immunodéficience, instabilité Centromérique et anomalies Faciales), première maladie génétique identifiée avec des défauts de la méthylation de l’ADN, liés à une instabilité chromosomique. Lorsque j'ai

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