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1

Bachmann, Michael. "Jerusalem in Lukasevangelium und Apostelgeschichte." Biblische Zeitschrift 65, no. 2 (2021): 266–97. http://dx.doi.org/10.30965/25890468-06502005.

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Abstract Undoubtedly the city Jerusalem (with its temple) is accentuated in Luke-Acts. This is indicated by the high frequency of the name(s) (Luke-Acts presents ca. 65% of the NT-instances!) Ἰερουσαλήμ and Ἱεροσόλυμα and also by the important role of the town within the structure, i.e. within the composition of the two books (cf. only Lk 1–2; 9:51; Acts 1:8; 19:21). But what does this emphasis mean? Differences in the understanding of the relevant data are obvious (and this matter resembles [not without cause] the intense discussions in the area of Pauline studies during the last decades). Ol
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Khatun, Rehana, and SM Shamsuzzaman. "Detection of OXA-181/OXA-48 carbapenemase producing Enterobacteriaceae in Bangladesh." Ibrahim Medical College Journal 9, no. 2 (2016): 45–51. http://dx.doi.org/10.3329/imcj.v9i2.28853.

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Carbapenem resistant Enterobacteriaceae (CRE) is becoming a major public health concern globally. Detection of carbapenem hydrolyzing enzyme carbapenemase in Enterobacteriaceae is important to institute appropriate therapy and to initiate preventive measures. This study was designed to determine the presence of carbapenemase producers among the CRE isolated from patients at Dhaka Medical College Hospital, Bangladesh. Twenty-nine CRE strains detected by disk diffusion technique were included in the study. Minimum inhibitory concentration of imipenem and tigecycline was determined by agar diluti
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3

von Segesser, L. K., B. M. Weiss, E. Garcia, E. von Felten, and M. I. Turina. "Coagulation Patterns in Perfusion with Low Systemic Heparinization." Journal of ExtraCorporeal Technology 23, no. 3 (1991): 80–85. http://dx.doi.org/10.1051/ject/199123380.

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Cardiopulmonary bypass (CPB) with heparin coated perfusion equipment was realized in 13 patients undergoing myocardial revascularization with either low (ACT> 180) or full systemic heparinization (ACT>480). Blood samples for coagulation and other studies were drawn before, after heparin, and at regular intervals during and after CPB. Heparinization low full p< Preop ACT s 118±6 112±13 NS PTT s 38±4 35±2 NS TT s 14±1 14±1 NS D-dimers mg/L <05 <0.5 NS Heparin IU 103 8±2 51±9 .01 CPB 60 min ACT s 230±19 594±287 .05 PTT s 56±9 94±63 .10 TT s >200 >200 NS D-dimers mg/L <0.5
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Gurram, Pooja, Natalia E. Castillo Almeida, Prakhar Vijayvargiya, et al. "92. Utility of Sinus CT in the Evaluation of Patients with Febrile Neutropenia." Open Forum Infectious Diseases 7, Supplement_1 (2020): S61—S62. http://dx.doi.org/10.1093/ofid/ofaa439.137.

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Abstract Background The etiology of febrile neutropenia in patients with hematological malignancy is identified in only 20–30% of cases. Sinus computed tomography (CT) is often used, regardless of symptoms, to rule out rhinocerebral source of infection. There are no clear guidelines on when to perform sinus CT in this population. In this study, we evaluated the role of sinus CT in febrile neutropenic patients. Methods We retrospectively reviewed medical records of all adults (age ≥18 years) with febrile neutropenia (T≥ 38.3ºC, ANC < 0.5 x 109/L) and hematological malignancies who underw
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Mora-Guzmán, Ismael, Inés Rubio-Pérez, Diego Domingo-Garcia, and Elena Martín-Pérez. "Infections by OXA-48 carbapenemase-producing Enterobacteriaceae in surgical patients: antibiotic consumption and susceptibility patterns." Revista Española de Quimioterapia 33, no. 6 (2020): 448–52. http://dx.doi.org/10.37201/req/081.2020.

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Objective. To assess antibiotic consumption, susceptibility patterns and targeted treatment for OXA-48 carbapenemase-producing Enterobacteriaceae (CPE) related infections in surgical patients in a General Surgery Department. Material and methods. Retrospective review of patients with a positive culture for OXA-48 and associated clinical data of infection, while hospitalized in a General Surgery Department from January 2013 to December 2018. Results. Sixty-five patients with 66 isolations (OXA-48) were included: Klebsiella pneumoniae, 57 (86.5%); Enterobacter cloacae, 5 (7.6%); Escherichia coli
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Peretto, Giovanni, Andrea Villatore, Stefania Rizzo, et al. "The Spectrum of COVID-19-Associated Myocarditis: A Patient-Tailored Multidisciplinary Approach." Journal of Clinical Medicine 10, no. 9 (2021): 1974. http://dx.doi.org/10.3390/jcm10091974.

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Background. Myocarditis lacks systematic characterization in COVID-19 patients. Methods. We enrolled consecutive patients with newly diagnosed myocarditis in the context of COVID-19 infection. Diagnostic and treatment strategies were driven by a dedicated multidisciplinary disease unit for myocarditis. Multimodal outcomes were assessed during prospective follow-up. Results. Seven consecutive patients (57% males, age 51 ± 9 y) with acute COVID-19 infection received a de novo diagnosis of myocarditis. Endomyocardial biopsy was of choice in hemodynamically unstable patients (n = 4, mean left vent
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Nagel, Anna, Agata Łaszewska, Gerald Haidinger, and Judit Simon. "The first 8 weeks of the Austrian SARS-CoV-2 epidemic." Wiener klinische Wochenschrift 133, no. 7-8 (2021): 364–76. http://dx.doi.org/10.1007/s00508-020-01804-9.

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Summary Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) reached Austria in February 2020. This study aims to describe the first 8 weeks of the Austrian epidemic and reflect on the potential mental health consequences as known at that time. Methods Data on Austrian Coronavirus Disease 19 (COVID-19) epidemiological indicators and number of tests were obtained from official registers. Relative risks (RRs) of infection and death from COVID-19 were calculated for sex and age groups (< 65 years and ≥ 65 years). Public health measures introduced to reduce the spread of COVI
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8

Sun, Cong, Hengqi Liu, Ningning Zhang, Xianhuo Wang, and Huilai Zhang. "Molecular landscape of distinct follicular lymphoma histologic grades: Insights from genomic and transcriptome analyses." Journal of Clinical Oncology 43, no. 16_suppl (2025): 7002. https://doi.org/10.1200/jco.2025.43.16_suppl.7002.

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7002 Background: The 2022 World Health Organization Classification of Hematologic Malignancies classifies follicular lymphoma grades 1-2 (FL1-2) and grade 3A (FL3A) as classical follicular lymphoma (cFL) and reclassifies grade 3B (FL3B) as follicular large B-cell lymphoma (FLBL), without addressing cases of patients with concurrent FL and DLBCL. However, genetic information of FL histologic grading remains limited, and the latest classification lacks sufficient evidence to resolve whether these subgroups represent single or multiple distinct biological entities. Methods: This study analyzed cl
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Sachs, Zohar, Michelle Dollan, Todd E. De For, et al. "Are IPSS-R and IPSS Cytogenetic Risk Stratification Informative At the Time of Allogeneic Hematopoietic Cell Transplantation?" Blood 120, no. 21 (2012): 1400. http://dx.doi.org/10.1182/blood.v120.21.1400.1400.

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Abstract Abstract 1400 Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell disorders. Cytogenetic aberrations are one of the main elements of risk stratification among published scoring systems including the International Prognostic Scoring System (IPSS) or its recent revision (R-IPSS). R-IPSS cytogenetic risk stratification has 5 cytogenetic subgroups rather than 3 in the IPSS. We hypothesized that R-IPSS and/or IPSS cytogenetic risk stratification at the time of allogeneic hematopoietic cell transplantation (alloHCT) can better predict outcome afterwards. In
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Correale, C., M. Di Pastena, I. Tondo, et al. "Prevalence of depressive and anxiety symptoms in chronically ill children and adolescents during COVID-19 pandemic and lockdown: Preliminary findings of a pediatric hospital in Italy." European Psychiatry 64, S1 (2021): S272. http://dx.doi.org/10.1192/j.eurpsy.2021.731.

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Introduction Psychological problems are common among the pediatric population suffering from a chronic illness, especially compared to the normal population. Stressful life events, such as social distancing measures implemented to counter the COVID-19 pandemic emergency, can strongly influence their epidemiology.ObjectivesThe aim of this study was to assess the prevalence rate of depressive and anxiety symptoms among an Italian pediatric population affected by chronic illness and already under a Children Hospital psychological follow-up program during COVID-19 lockdown.MethodsWe conducted a cr
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Ferrari, S., S. Smeland, S. Bielack, et al. "A European treatment protocol for bone sarcoma in patients older than 40 years." Journal of Clinical Oncology 27, no. 15_suppl (2009): 10516. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.10516.

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10516 Background: EUROpean Bone Over 40 Sarcoma Study (EURO-B.O.S.S.) is the first prospective multicenter international study for patients 41 - 65 years old with high-grade bone sarcoma. Methods: Patients with HG Osteosarcoma (OS), HG sarcoma NOS (S), Fibrosarcoma, MFH, Leiomyosarcoma, Dedifferentiated Chondrosarcoma (DCh) were included. Chemotherapy: Combinations of cisplatin/doxorubicin (CDP 100mg/m2/ADM 60mg/m2), ifosfamide/CDP(IFO 6g/m2/CDP 100mg/m2) and IFO/ADM (IFO 6g/m2/ADM 60mg/m2) were repeated three times (9 cycles). Surgery was planned after 3 cycles. Methotrexate (8g/m2) was posto
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Stai, Stamatia, Asimina Fylaktou, Efstratios Kasimatis, et al. "Immune Profile Determines Response to Vaccination against COVID-19 in Kidney Transplant Recipients." Vaccines 11, no. 10 (2023): 1583. http://dx.doi.org/10.3390/vaccines11101583.

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Background and Aim: Immune status profile can predict response to vaccination, while lymphocyte phenotypic alterations represent its effectiveness. We prospectively evaluated these parameters in kidney transplant recipients (KTRs) regarding Tozinameran (BNT162b2) vaccination. Method: In this prospective monocenter observational study, 39 adult KTRs, on stable immunosuppression, naïve to COVID-19, with no protective humoral response after two Tozinameran doses, received the third vaccination dose, and, based on their immunity activation, they were classified as responders or non-responders. Hum
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Nachtkamp, Kathrin, Andrea Kuendgen, Barbara Hildebrandt, Norbert Gattermann, Rainer Haas, and Ulrich Germing. "Hematological Characteristics of Patients with Myelodysplastic Syndromes in the Light of WHO 2008 Proposals." Blood 112, no. 11 (2008): 1658. http://dx.doi.org/10.1182/blood.v112.11.1658.1658.

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Abstract Myelodysplastic syndromes have been reclassified by new WHO proposals published in 2008. So far, there are no data on haematological features of the newly composed subtypes. We analyzed 2063 patients with MDS diagnosed according to the WHO 2008 classification. Patients were characterized by their initial haematological features. We especially payed attention towards isolated cytopeniae with regard to the new classification of MDS subcategories. Analyses were performed by the use of the MDS registry Duesseldorf and included hemoglobin level, platelets, leukocytes and karyotype (availab
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14

Mandia, Jeremy, Freddy Escorcia, Holly Ning, Kilian Elizabeth Salerno, Deborah E. Citrin, and Lindsay S. Rowe. "Bowel and bladder reproducibility in image-guided SBRT prostate: Results of a patterns of practice survey." Journal of Clinical Oncology 37, no. 7_suppl (2019): 76. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.76.

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76 Background: Use of prostate stereotactic body radiotherapy (SBRT) as treatment for localized prostate cancer (PCa) is increasing. Given the high dose (>5Gy) per fraction (Fx) being delivered, SBRT requires careful preparation and delivery to ensure accuracy and precision. Guidelines and data on best practice for bowel and bladder preparation are lacking. Therefore, we surveyed practicing radiation oncologists (RO) to document practice patterns for prostate SBRT. Methods: From June to October 2018 we completed a nationwide survey of 1395 American Society for Therapeutic Radiology and Onco
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15

SUSANTI, R., RETNO SRI ISWARI, FIDIA FIBRIANA, and INDRIAWATI INDRIAWATI. "The duck cytochrome oxidase I (COI) gene: Sequence and patterns analysis for potential barcoding tool." Biodiversitas Journal of Biological Diversity 19, no. 3 (2018): 997–1003. http://dx.doi.org/10.13057/biodiv/d190331.

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Susanti R, Iswari RS, Fibriana F, Indriawati. 2018. The duck cytochrome oxidase I (COI) gene: Sequence and patterns analysis for potential barcoding tool. Biodiversitas 19: 997-1003. The local duck DNA barcoding is still rarely conducted in Indonesia while DNA barcoding is extensively used as a tool of species identification and delineation tool. This study aimed to analyze the sequence and patterns of Central Javanese ducks mitochondrial cytochrome c oxidase subunit 1 (COI) gene. Feather samples of seven breeds of native duck were collected from traditional husbandries in Central Java. The sa
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16

Santillán-Doherty, Patricio, Luis Marcelo Argote-Greene, and Martin Guzman-Sanchez. "Thoracoscopic Management of Primary Spontaneous Pneumothorax." American Surgeon 72, no. 2 (2006): 145–49. http://dx.doi.org/10.1177/000313480607200210.

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Primary spontaneous pneumothorax is defined as that which appears in patients without history of previous pathology that could explain the event. Management includes pleural drainage with or without pleurodesis and surgical resection of affected lung tissue with pleurodesis. Thoracoscopic approach has proved to be useful with low morbidity and mortality as well as low recurrence rate. This paper describes the experience with thoracoscopic management of primary spontaneous pneumothorax with pulmonary wedge resection of affected tissue, parietal pleurectomy, and pleural abrasion of remaining par
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Butylin, Pavel, Natalia Matyuhina, Ekaterina Lisina, et al. "Calreticulin Mutations Variants of ET and PMF Patients Studied in Almazov Medical Research Center Russian Federation." Blood 128, no. 22 (2016): 5499. http://dx.doi.org/10.1182/blood.v128.22.5499.5499.

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Abstract We analyzed CALR mutations in cohort of patients with ET and PMF. Diagnoses were determined according to the WHO criteria. 33 PMF and 45 ET patients that were negative for JAK2V617F and MPL515L/K mutations have been studied for CALR mutations presence as described in original paper (Т.Klampfi , 2013). 29 ET and 25 PMF patients found mutated. In PMF group sex ratio was equal - 12 males/13 females, in ET group females prevailed - 21 males/69 females. Median age in PMF group was 64 (41-78) and in ET group 58 (22-80). Exon 9 was Sanger sequenced and mutation type identified. All the mutat
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18

Ilson, D. H., M. Bains, N. Rizk, et al. "Phase II trial of preoperative cisplatin-irinotecan followed by concurrent cisplatin-irinotecan and radiotherapy: PET scan after induction therapy may identify early treatment failure." Journal of Clinical Oncology 24, no. 18_suppl (2006): 4023. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4023.

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4023 Background: Response on PET scan during preoperative chemotherapy (chemo) for esophageal cancer (EC) has prognostic significance [JCO 19:3058;2001]. Induction chemo with weekly irinotecan(I)/cisplatin(C) relieves dysphagia, and weekly I/C administered with radiotherapy (RT) is well tolerated [ProcASCO 23:Abs 4017;2005]. We completed a Phase II trial of induction I/C followed by I/C/RT followed by surgery. Repeat PET scan was performed after induction chemo and prior to RT. Methods: Patients (pts) with resectable EC/GE junction carcinoma were staged with EUS, PET, and CT scan. Induction ch
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Geschwind, Michael, A. Sebastian Lopez-Chiriboga, Kyle Blackburn, et al. "Autoimmune Encephalitis Misdiagnosis in Adults; A Multicenter Observational Study of Outpatient Subspecialty Clinics." Neurology 99, no. 23 Supplement 2 (2022): S55.2—S57. http://dx.doi.org/10.1212/01.wnl.0000903448.98416.0e.

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ObjectiveTo determine the diseases misdiagnosed as AE and potential reasons for misdiagnosis.BackgroundMisdiagnosis of autoimmune encephalitis (AE) may harm patients.Design/MethodsPatients with AE misdiagnosis were identified (1/1/2014-12/31/2020) from outpatient AE subspecialty clinics including: Mayo Clinic (n = 44); Oxford (n = 18); UT Southwestern (n = 18); UCSF (n = 17); Washington University (n = 6); University of Utah (n = 4). Inclusion criteria were adults (=18 years) with: 1) A prior diagnosis of AE; and 2) An alternative diagnosis made at a participating center. We collected data on
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Alverdiyeva, S. M. "DIVERSITY OF FOLIOSE LICHENSPECIES IN AZERBAIJAN." Bulletin of Nizhnevartovsk State University, no. 2 (June 15, 2019): 20–31. http://dx.doi.org/10.36906/2311-4444/19-2/03.

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This article consolidates lichenological data on foliose lichens of Azerbaijan and addresses their species diversity. It was determined that the studied lichens belong to classes Eurotiomycetes, Lecanoromycetes and Lichenomycetes of the phylum Ascomycota. They are represented by 166 species, including 8 orders: Caliciales , Candelariales, Lecanorales , Peltigerales , Teloschistales , Umbilicariales , Verrucariales , Lichinales ; 15 families: Candelariaceae, Collemataceae, Lecanoraceae, Lobariaceae, Nephromataceae, Pannariaceae, Parmeliacea e, Peltigeraceae, Peltylaceae, Physciaceae , Placynthi
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21

Marcoux, Diane, Isabelle Etienne, Alain Van Muylem, et al. "A Retrospective, Monocentric Study Comparing Co and Secondary Infections in Critically Ill COVID-19 and Influenza Patients." Antibiotics 11, no. 6 (2022): 704. http://dx.doi.org/10.3390/antibiotics11060704.

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Few data are available on infectious complications in critically ill patients with different viral infections. We performed a retrospective monocentric study including all of the patients admitted to the intensive care unit (ICU) with confirmed COVID-19 (as of 13 March 2020) or Influenza A and/or B infections (as of 1 January 2015) until 20 April 2020. Coinfection and secondary infections (occurring within and after 48 h from admission, respectively) were recorded. Fifty-seven COVID-19 and 55 Influenza patients were included. Co-infections were documented in 13/57 (23%) COVID-19 patients vs. 4
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Marwan, Marwan, Khalidi Rizqan, Siti Khotimah, Sri Wahyunie, Kalalo Pertiwi, and Fanny Gomarjoyo. "Association between oxygen saturation, neutrophil-lymphocyte ratio and D-dimer with mortality based on clinical manifestation of COVID-19 patients." Scripta Medica 52, no. 4 (2021): 284–88. http://dx.doi.org/10.5937/scriptamed52-34641.

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Background/Aim: Coronavirus 2019 (COVID-19) infection is caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has become an emergency condition for global public health. Oxygen saturation has important role for diagnosing the patient in the hospital. The neutrophil-lymphocyte ratio (NLR) is a marker for the viral inflammatory reaction to confirm the viral or bacterial infection. The D-dimer is also known as biomarker for severity and prognosis of COVID-19. The aim of the study was to investigate the risk factors of mortality in COVID-19 patients based on oxygen satur
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23

Souza, Mellany Cardoso, Thainá Cruz Magalhães, Victoria Gastaldelo, Júlia Maria de Souza Oliveira, Ingrid de Oliveira Silva, and Danyelle Cristine Marini. "Impacto pós-pandêmico nas doenças mentais e uso de substâncias psicoativas." Cuadernos de Educación y Desarrollo 16, no. 9 (2024): e5600. http://dx.doi.org/10.55905/cuadv16n9-078.

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A pandemia da Covid-19 impactou negativamente a economia e a saúde no âmbito global, e mesmo após esse trágico acontecimento, ainda vem trazendo suas consequências na saúde sobre os transtornos mentais da população. Este estudo teve como objetivo demonstrar os tipos de transtornos mentais e cognitivos adquiridos ou intensificados após a pandemia da Covid-19, como em alguns transtornos de depressão e ansiedade. O trabalho abordou os efeitos de drogas psicoativas e como agem no organismo, subsequentes do uso dessas substâncias em pessoas que fazem tratamento para tais desordens mentais. Para iss
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24

García-Lara, Rubén A., Nora Suleiman-Martos, María J. Membrive-Jiménez, et al. "Prevalence of Depression and Related Factors among Patients with Chronic Disease during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis." Diagnostics 12, no. 12 (2022): 3094. http://dx.doi.org/10.3390/diagnostics12123094.

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The management of chronic diseases in the midst of the COVID-19 pandemic is especially challenging, and reducing potential psychological harm is essential. This review aims to determine the prevalence of depression during the COVID-19 pandemic in patients with chronic disease, and to characterize the impacts of related factors. A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The meta-analysis was performed using StatsDirect software. The review identified 33 articles with a total of 50,905 patients
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25

Poglajen, Gregor, Gregor Zemljič, Andraž Cerar, et al. "Transendocardial CD34+ Cell Therapy does not Increase the Risk of Ventricular Arrhythmias in Patients with Chronic Heart Failure." Cell Transplantation 28, no. 7 (2019): 856–63. http://dx.doi.org/10.1177/0963689719840351.

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Ventricular arrhythmias (VA) are of major concern in the field of cell therapy, potentially limiting its safety and efficacy. We sought to investigate the effects of CD34+ cell therapy on VA burden in patients with chronic heart failure (CHF). We performed registry data analysis of patients with CHF and implanted ICD/CRT devices treated with transendocardial CD 34+ cell therapy. Demographic, echocardiographic, and biochemical parameters were analyzed. Device records were reviewed and the number and type of VA 1 year prior to and 1 year after cell therapy were analyzed. All patients underwent e
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Semiletova, V. A. "CHANGES IN THE PARAMETERS OF VISUAL EVENT POTENTIALS TO A FLASH UNDER 48 THE INFLUENCE OF SPELEOTHERAPY." Journal of Volgograd State Medical University 19, no. 3 (2022): 48–51. http://dx.doi.org/10.19163/1994-9480-2022-19-3-48-51.

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The purpose of our study is to study changes in the parameters of visual evoked potentials to a flash under the influence of speleotherapy. Material and research methods. The study involved 23 2nd year students of VSMU (18-21 years old, 9 boys and 14 girls). The course of speleotherapy consisted of 10 sessions of 60 minutes each and was carried out in a stationary ground speleochamber at a temperature of 18-22 °C. The study was conducted in compliance with the basic bioethical rules. Before the start of speleotherapy, on the 3rd, on the 10th day of speleotherapy, visual evoked potentials (vEP)
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27

Swinton, N., G. Kasymjanova, T. Steinberg, et al. "Do most newly diagnosed advanced NSCLC patients need nutritional intervention?" Journal of Clinical Oncology 25, no. 18_suppl (2007): 9108. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.9108.

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9108 Background: Depletion of nutritional reserves and significant weight loss are commonly noted in patients (pts) with non-small cell lung cancer (NSCLC). The Patient Generated Subjective Global Assessment (PG-SGA) is a nutritional screening tool for cancer pts, recommended by the Oncology Network of Dietitians of Canada and the American Dietetic Association. The PG-SGA categorizes total scores into 4 ranges for nutritional triage: 0–1 requires no intervention, 2–3 requires education, 4 - 8 requires intervention by a dietitian, and =9 requires urgent symptom control and nutrition interventio
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28

Moritz, William E. "Adult Bicyclists in the United States: Characteristics and Riding Experience in 1996." Transportation Research Record: Journal of the Transportation Research Board 1636, no. 1 (1998): 1–7. http://dx.doi.org/10.3141/1636-01.

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In December 1996, 20 percent (4,712) of the League of American Bicyclists members were surveyed about their cycling experiences during calendar year 1996. The 33 questions included bicycle type and equipment, distribution of bicycle trips by purpose (e.g., work, on-road recreation), total distance cycled, commuting habits, accidents, and demographic data. The survey was designed to update one done by Kaplan in 1975. By the March 31, 1997, deadline over 2,400 (51 percent) had been returned. Of these, 19 percent were rejected due to incompleteness or inconsistent responses, leaving 1,956 valid s
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Arora, Mukta, Sriharsha Nagaraj, John E. Wagner, et al. "Chronic Graft Versus Host Disease (cGVHD) Following Unrelated Donor Hematopoietic Stem Cell Transplantation (HSCT): Higher Response Rate in Recipients of Unrelated Donor (URD) Umbilical Cord Blood (UCB)." Blood 106, no. 11 (2005): 1814. http://dx.doi.org/10.1182/blood.v106.11.1814.1814.

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Abstract The nature of chronic graft versus host disease (cGVHD) after umbilical cord blood (UCB) transplant has not been well characterized. We analyzed clinical presentation and response to treatment in 170 patients with cGVHD (123 following transplant from an unrelated donor (URD) and 47 following transplant from UCB). URD transplant recipients were significantly younger (median age 25 (0.5–57) versus 39 (0.2–61) years, p = 0.002; and were less likely to receive a transplant from an HLA mismatched donor (33% versus 90%, p<0.0001). Seven% and 43% of patients underwent a transplant usi
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Fazili, Zia, Christine M. Pfeiffer, Mindy Zhang, Ram B. Jain, and Deborah Koontz. "Influence of 5,10-Methylenetetrahydrofolate Reductase Polymorphism on Whole-Blood Folate Concentrations Measured by LC-MS/MS, Microbiologic Assay, and Bio-Rad Radioassay." Clinical Chemistry 54, no. 1 (2008): 197–201. http://dx.doi.org/10.1373/clinchem.2007.096545.

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Abstract Background: The 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR). Methods: We analyzed 171 whole blood hemolysates from 2 blood banks for folate pattern and total folate concentrations using these 3 methods and determined MTHFR genotype. Results: The median (range) total folate concentration by LC-MS/MS was higher in the US set [378 (228–820) nmol/L; n = 96] than in
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Brown, Karen T., Richard K. Do, Mithat Gonen, et al. "Randomized Trial of Hepatic Artery Embolization for Hepatocellular Carcinoma Using Doxorubicin-Eluting Microspheres Compared With Embolization With Microspheres Alone." Journal of Clinical Oncology 34, no. 17 (2016): 2046–53. http://dx.doi.org/10.1200/jco.2015.64.0821.

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Purpose Transarterial chemoembolization is accepted therapy for hepatocellular carcinoma (HCC). No randomized trial has demonstrated superiority of chemoembolization compared with embolization, and the role of chemotherapy remains unclear. This randomized trial compares the outcome of embolization using microspheres alone with chemoembolization using doxorubicin-eluting microspheres. Materials and Methods At a single tertiary referral center, patients with HCC were randomly assigned to embolization with microspheres alone (Bead Block [BB]) or loaded with doxorubicin 150 mg (LC Bead [LCB]). Ran
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Veveloyiannis, Panayiotis, Nikolaos Bafaloukas, and Dimitra S. Mouliou. "MoLEP vs. HoLEP for BPH: A 3-Year Greek Single-Center Retrospective Comparative Cohort Study on 1368 Cases." Cancers 17, no. 10 (2025): 1608. https://doi.org/10.3390/cancers17101608.

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Background: Holmium Laser Enucleation of the Prostate (HoLEP) is an established treatment for benign prostatic hyperplasia (BPH). Pulse-modulated lasers, like MOSES technology (MoLEP), may enhance the procedure’s efficiency and safety. Methods: A 3-year single-center retrospective comparative study was conducted on 1368 patients treated with HoLEP/MoLEP at MITERA Hospital. Results: A total of 688 patients were treated with HoLEP and 680 with MoLEP. Compared to HoLEP, MoLEP demonstrated shorter surgical (50.5 min [IQR 33–60] vs. 58 min [IQR 46–69], p < 0.01) and enucleation times (34 min [IQ
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Semeraro, P., S. Piantoni, G. Vairano, et al. "AB1311 EVALUATION OF A POTENTIAL INDUCTION OF AUTOANTIBODIES IN A COHORT OF PATIENTS AFFECTED BY RHEUMATOID ARTHRITIS, SYSTEMIC SCLEROSIS OR WITH TRIPLE POSITIVITY FOR ANTIPHOSPHOLIPID ANTIBODIES FOLLOWING ANTI-SARS-CoV2 VACCINATION." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1884–85. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3497.

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BackgroundVaccines anti-SARS-CoV2 showed a good efficacy in prevention of severe COVID-19 [1]. Their potential in induction of autoantibodies (abs) has not been well established [1]. One recent study demonstrated an increase of abs’ titer after anti-SARS-CoV2 vaccination only in patients (pts) with already pre-existing positivity [2].ObjectivesTo evaluate the potential induction of abs after SARS-CoV2 vaccination in a cohort of pts affected by Rheumatoid Arthritis (RA), Systemic Sclerosis (SSc) or with triple positivity for antiphospholipid antibodies (aPL).MethodsConsecutive pts affected by R
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Geragotellis, A., S. Patel, M. A, et al. "Tenofovir alafenamide: An initial experience at Groote Schuur Hospital, Cape Town, South Africa." South African Medical Journal 112, no. 2 (2022): 113–16. http://dx.doi.org/10.7196/samj.2022.v112i2.16188.

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Background. Hepatitis B virus (HBV) remains endemic in South Africa (SA), with a concomitantly high prevalence of HIV co-infection. Chronic kidney disease in these subpopulations also has a high prevalence. Tenofovir is an important component of management, but the associated risk of nephrotoxicity makes dosing a challenge in patients with impaired kidney function. A new formulation, tenofovir alafenamide fumarate (TAF), with a more favourable renal toxicity profile, is now available. Objectives. To evaluate our initial experience of TAF use at Groote Schuur Hospital, Cape Town. Methods. We re
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Gal-Or, Benjamin. "Jet-Engines Revised Dictionary for the 6th-Generation-R&D in a New Era." International Journal of Turbo & Jet-Engines 36, no. 2 (2019): 127–36. http://dx.doi.org/10.1515/tjj-2019-9016.

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AbstractNew U.S.-DOD guiding instructions for 2019 JEST-R&D funded proposals, are now available, [1]. Past U.S.-decision “not to weaponize” JEST, has induced it to advance Anti-Gliding-Hypersonic-Scramjet-Threats, (GHST), [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20]. This editorial updates previous ones, [21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31], mainly on RE-EDUCATING JET-ENGINE RESEARCHERS TO STAY RELEVANT, especially in JETONAUTIC-POST-STALL-FLIGHT, where AOOF fails, [32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54
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Castell, J. V., G. Friedrich, C. S. Kuhn, and G. E. Poppe. "Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake." American Journal of Physiology-Gastrointestinal and Liver Physiology 273, no. 1 (1997): G139—G146. http://dx.doi.org/10.1152/ajpgi.1997.273.1.g139.

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The human adult intestinal epithelium has traditionally been described as nonpermeable to proteins. However, indirect evidence suggests that reduced absorption of undegraded proteins might take place under physiological conditions. Using bromelain (an enzyme obtained from pineapple stems) as a model protein, we studied the extent of this mucosal permeation in 19 healthy men. The protein was detected in plasma by immunoassay and by its proteolytic activity after oral administration. The estimated plasma half-life was 6–9 h. After oral multidosing (3 g/day), plasma concentration reached as much
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Verstappen, Gwenny M., Liseth de Wolff, Suzanne Arends, et al. "Immunogenicity and safety of COVID-19 vaccination in patients with primary Sjögren’s syndrome." RMD Open 8, no. 1 (2022): e002265. http://dx.doi.org/10.1136/rmdopen-2022-002265.

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ObjectivesTo evaluate humoral and cellular immune responses and adverse events (AEs) after COVID-19 vaccination in patients with primary Sjögren’s syndrome (pSS) compared to healthy controls (HC), and disease activity following vaccination in patients with pSS.Methods67 patients with pSS and 33 HC (ratio 2:1) received COVID-19 vaccinations following the Dutch vaccination programme. Patients with pSS did not use immunomodulatory drugs, except hydroxychloroquine. Anti-spike 1 receptor binding domain IgG serum antibody levels were measured 28 days after complete vaccination. AEs were collected 7
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Chang, Chia-Yau, Shiue-Wei Lai, Mei-Mei Cheng, et al. "Real-World Bleeding Outcomes, Weekly Factor Consumption Doses, Annualized Factor Costs in Severe-Type Patients with Hemophilia a (PwHA) before and after Switching to Extended Half-Life rFVIII-Fc Prophylaxis." Blood 138, Supplement 1 (2021): 3198. http://dx.doi.org/10.1182/blood-2021-152066.

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Abstract Introduction: Stand half-life (SHL) rFVIII had been used in patients with hemophilia A (PwHA) for episodic treatment (ET) and prophylaxis therapy (PT) for years. Extended half-life (EHL) rFVIII had been available since 2014, also available in Taiwan since 2018, and resulted in markedly increased willingness for PT because it reduced injection burden. We aimed to investigate the real-world bleeding outcomes, weekly factor doses, and factor costs of severe-type PwHA with pre-switch SHL rFVIII and post-switch EHL rFVIIIFc prophylaxis in Taiwan, and made a pre-switch and post-switch compa
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Leonard, John P., Andrew D. Zelentz, Julie M. Vose, and Mark S. Kaminski. "Impact of Course of Therapy on Response Rate and Duration with the Bexxar® Therapeutic Regimen (Tositumomab and Iodine I 131 Tositumomab) and with Chemotherapy." Blood 104, no. 11 (2004): 132. http://dx.doi.org/10.1182/blood.v104.11.132.132.

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Abstract Low grade NHL with or without transformation is characterized by recurrence. Initial response rates with chemotx are high, but all patients ultimately relapse, and the response rates and durations of response typically decline with each subsequent course of chemotx. In the pivotal trial of Bexxar (JCO 19:3918 2001) there were significantly more patients with longer durations of response than after their last qualifying chemotx. The aim of the current retrospective study was to evaluate the efficacy of Bexxar and prior chemotx by course of treatment in a larger group of patients. Respo
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Kukreti, Vinay, Mika Nonoyama, Efrosini Papaconstantinou, et al. "48 Paediatric intubation in an adult-based community hospital emergency department (ED)." Paediatrics & Child Health 25, Supplement_2 (2020): e20-e20. http://dx.doi.org/10.1093/pch/pxaa068.047.

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Abstract Background Airway intubation is a high-risk procedure, especially in the paediatric population. Training ED healthcare providers is challenging because it is rare. Success and adverse events (AEs) could be due to patients’ illness, the health professional intubating, and hospital factors. Objectives Describe paediatric intubations in an adult community-based hospital, with primary outcomes being first-pass success and AEs. The secondary objective is to determine what factors are association with intubation success and related AEs. Design/Methods Retrospective chart review of patients
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Osterlund, Pia J., Joel Kontiainen, Kaisa Inkeri Lehtomäki, et al. "Relapse patterns, risk factors, re-resectability and survival after curative treatment for metastatic colorectal cancer (mCRC): A RAXO substudy." Journal of Clinical Oncology 43, no. 16_suppl (2025): 3566. https://doi.org/10.1200/jco.2025.43.16_suppl.3566.

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3566 Background: In mCRC, metastasectomy and/or local ablative treatment (LAT) cures some. However, over 70% of the patients relapse, with liver, lung and peritoneum being the most common recurrence sites. Data on recurrence patterns and prognostic factors are mainly limited to patients with liver metastases treated before 2008. An update including patients also with multisite metastases treated up-to-date is needed. Methods: In this study, 323 patients from the RAXO-study (2012–2018) were analyzed, 312 patients had undergone R0–1 metastasectomy and 11 patients had A0–1 LAT. Three patients wit
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Fayad, Luis, Hemant Patel, Gregor Verhoef, et al. "Clinical Activity of the Immunoconjugate CMC-544 in B-Cell Malignancies: Preliminary Report of the Expanded Maximum Tolerated Dose (MTD) Cohort of a Phase 1 Study." Blood 108, no. 11 (2006): 2711. http://dx.doi.org/10.1182/blood.v108.11.2711.2711.

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Abstract Introduction: CMC-544 is an antibody-targeted chemotherapy agent composed of a humanized antibody that specifically targets the CD22 antigen, conjugated to calicheamicin, a potent cytotoxic antitumor agent. Malignant cells of mature B-lymphocyte lineage express CD22, suggesting that CMC-544 may be useful for treating lymphomas of B-cell origin. A phase 1 dose-escalation trial of CMC-544 was performed at 14 European and US sites with 36 patients in the dose escalation portion and 48 in the expanded MTD portion. The MTD dose was 1.8 mg/m2 every 4 weeks. In the dose escalation phase the
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Bairi, Y., C. Brassard, J. Paul, et al. "P.044 The impact of working hours on rapid GFAP measurement in acute stroke: evaluation of sampling bias in an ongoing prospective study." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 52, s1 (2025): S26. https://doi.org/10.1017/cjn.2025.10218.

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Background: Glial fibrillary acidic protein (GFAP), a brain-specific biomarker, shows promise in differentiating intracerebral hemorrhage (ICH) from acute ischemic stroke (IS) and stroke mimics (SM). A novel point-of-care platform measures GFAP in minutes, yet requires centrifugation to obtain plasma. We aim to determine whether participants recruited in an ongoing prospective biomarker study (during working hours) differ from non-recruited patients. Methods: An exploratory analysis of undifferentiated stroke <24h from onset, where plasma GFAP levels (pg/ml) are measured (i-STAT Alinity) at
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El-Cheikh, Jean, Catherine Faucher, Mohamad Mohty, et al. "Allogeneic Stem Cell Transplantation (allo-SCT) in Patients with Secondary Acute Myelogenous Leukemia (AML) or High Risk Myelodysplastic Syndromes (MDS)." Blood 106, no. 11 (2005): 5416. http://dx.doi.org/10.1182/blood.v106.11.5416.5416.

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Abstract Secondary AML and high risk MDS represent a poor risk group of myeloid malignancies. We report here the results of a single center retrospective study of allo-SCT in 28 patients (median age, 42 y.) with secondary AML (n=19; 68%) and MDS (n=9; 22%). Eleven patients (39%) had therapy-related AML (t-AML). FAB categories included: AR/ARS: 3, AREB/AREBt: 6, M0: 1, M1–M2: 9, M4–M5: 5, M6: 3, and one patient could not be classified. Cytogenetics features were: poor risk in 20 patients (71%), normal in 5 patients (19%) and not evaluated in 3 (10%). Allo-SCT was performed as first line therapy
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Uzunparmak, Burak, Cara Haymaker, Gabriela Raso, et al. "Abstract 961: HER2-low expression in patients with advanced or metastatic solid tumors." Cancer Research 83, no. 7_Supplement (2023): 961. http://dx.doi.org/10.1158/1538-7445.am2023-961.

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Abstract Introduction: HER2 protein expression by immunohistochemistry (IHC) has been the main testing method for breast and gastric cancers. Much remains unknown about the frequency of HER2-low (IHC 1+ or 2+) expression and the change of HER2 status from primary to metastatic tumor samples. There is limited data available about the HER2-low frequency in solid tumors beyond breast and gastric/gastroesophageal (GEJ) cancer. Methods: HER2 IHC was performed in 923 patients (pts) with metastatic breast and 51 pts with gastric/GEJ cancers in CLIA-certified labs. We evaluated the HER2 IHC in paired
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Khelkovskaia-Sergeeva, A., O. Desinova, M. Starovoytova, L. P. Ananyeva, M. Cherkasova та R. Shayakhmetova. "AB0444 СLINICAL-IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH INFLAMMATORY MYOPATHIES". Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1249.3–1250. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3101.

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Background:Inflammatory disorders of the skeletal muscle include polymyositis (PM), dermatomyositis (DM), amyopathic dermatomyositis ADM, (immune mediated) necrotizing myopathy (NM), overlap syndrome with myositis (overlap myositis, OM) and including anti-synthetase syndrome (ASS).The detection of myositis-specific antibodies, the clinical effect of which remains to be determined, may be of great importance for diagnosis.Objectives:To study clinical-immunological characteristics of patients with inflammatory myopathies.Methods:57 pts were enrolled in this study: 28 (47%) pts were diagnosed wit
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NIETO GARCIA, ZULEYMA, Edgar Omar Martos Armendáriz, Vanessa Rosas Camargo, et al. "Neoadjuvant treatment in a Mexican cohort of patients with locally advanced rectal cancer: Oncologic outcomes and prognostic factors." Journal of Clinical Oncology 37, no. 4_suppl (2019): 704. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.704.

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704 Background: Preoperative chemoradiotherapy (CRT) followed by total mesorectal excision (TME) and adjuvant chemotherapy (CT) is the standard of care for locally advanced rectal cancer (LARC). Total neoadjuvant therapy (TNT) consists of induction CT followed by CRT prior to surgery. This is an alternative strategy recommended in guidelines. Objective: To describe neoadjuvant strategies, oncologic outcomes and prognostic factors in a cohort of patients (pts) with LARC treated at a referral center in Mexico City. Methods: We retrospectively reviewed medical records from pts with LARC (T3-T4 or
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LORD, JENNIFER S., STEVE PARKER, FIONA PARKER, and DARREN R. BROOKS. "Gastrointestinal helminths of pipistrelle bats (Pipistrellus pipistrellus/Pipistrellus pygmaeus) (Chiroptera: Vespertilionidae) of England." Parasitology 139, no. 3 (2012): 366–74. http://dx.doi.org/10.1017/s0031182011002046.

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SUMMARYAlthough bats are one of the most successful and diverse of mammalian orders, studies that focus upon bat endoparasites are limited. To further knowledge of bat parasitology, pipistrelle bats (Pipistrellus pipistrellus and P. pygmaeus) were acquired from across the Greater Manchester and Lancashire region of England and examined for gastrointestinal helminths using morphological and molecular analyses†. Sixty-eight of 90 adult/juvenile bats (76% prevalence) were infected with at least 1 species of helminth and mean helminth abundance was 48·2 (+/−7·0). All helminths were digenean tremat
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Peddie, Meredith C., Tessa Scott, and Jillian J. Haszard. "Using a 24 h Activity Recall (STAR-24) to Describe Activity in Adolescent Boys in New Zealand: Comparisons between a Sample Collected before, and a Sample Collected during the COVID-19 Lockdown." International Journal of Environmental Research and Public Health 18, no. 15 (2021): 8035. http://dx.doi.org/10.3390/ijerph18158035.

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Background: Tools that assess all three components of 24 h movement guidelines (sleep, physical activity, and screen use) are scarce. Our objective was to use a newly developed Screen Time and Activity Recall (STAR-24) to demonstrate how this tool could be used to illustrate differences in time-use across the day between two independent samples of male adolescents collected before and during the COVID-19 lockdown. Methods: Adolescent boys aged 15–18 years (n = 109) each completed the STAR-24 twice, n = 74 before lockdown and n = 35 during lockdown. Results: During lockdown more than 50% of the
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Barbhaiya, M., D. Erkan, Y. Ahmadzadeh, K. Costenbader, R. Naden, and S. Zuily. "OP0097 DEVELOPMENT OF NEW INTERNATIONAL CLASSIFICATION CRITERIA FOR ANTIPHOSPHOLIPID SYNDROME: PHASE III CASE COLLECTION RESULTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 64.2–64. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5294.

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Background:An international multi-disciplinary effort is underway to develop rigorous, new, consensus- and evidence-based classification criteria for Antiphospholipid Syndrome (APS). The methodological approach includes four phases; we have previously presented phases I and II (item generation and reduction), which resulted in 27 candidate criteria1organized in laboratory and clinical domains.Objectives:Phase III (item weighting/threshold identification) is currently underway; here we report initial Phase III case collection results.Methods:We used REDCap, a secure data system, for Phase III i
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