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Thematische Bibliographien / Microparticulate dosage / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Microparticulate dosage“

Autor: Grafiati

Veröffentlicht am 18. Mai 2024

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1

Kokate, Shekhar, and Punit R. Rachh. "Microparticulate hot melt pallets technology: a review." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 377–83. http://dx.doi.org/10.22270/jddt.v8i6-s.2131.

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Recent advances in novel drug delivery (NDDS) aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. Depending upon functionality, it is possible to design different dosages forms which fulfill the therapeutic needs of the patient with improved bioavailability of poorly water soluble drugs, taste masking and preparation of oral dispersible tablets, MUPS and multiple unit formulations. The hot-melt technology is one of the most commonly used method, is devoid of solvent use, solvent dispos

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Chikukwa, Mellisa T. R., Roderick B. Walker, and Sandile M. M. Khamanga. "Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form." Pharmaceutics 12, no. 8 (2020): 712. http://dx.doi.org/10.3390/pharmaceutics12080712.

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Cardiovascular diseases such as hypertension and cardiac failure in South African children and adolescents are effectively managed long term, using a combination treatment of captopril and hydrochlorothiazide. The majority of commercially available pharmaceutical products are designed for adult patients and require extemporaneous manipulation, prior to administration to paediatric patients. There is a need to develop an age appropriate microparticulate dosing technology that is easy to swallow, dose and alter doses whilst overcoming the pharmacokinetic challenges of short half-life and biphasi

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Fathima, A., B. N. Vedha Hari, and D. Ramya Devi. "Development of Microparticulate Sustained Release Dosage Form of Emtricitabine: An Anti-HIV Drug." Asian Journal of Chemistry 26, no. 9 (2014): 2604–10. http://dx.doi.org/10.14233/ajchem.2014.15757.

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Sah, Shiv Kumar, Mrs Vasia, Rajkumar Prasad Yadav, Sunny Patel, and Mukesh Sharma. "Microsphere Overview." Asian Journal of Pharmaceutical Research and Development 9, no. 4 (2021): 132–40. http://dx.doi.org/10.22270/ajprd.v9i4.1003.

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The aim of developing continuous or managed delivery mechanisms has always been to minimise dosage duration, resulting in improved patient compliance and less side effects. Microspheres have been shown to minimise dosage, side effects, administration frequency, and the risk of dose dumping. As a result, patient compliance has improved.Targeted drug delivery mechanisms aim for a specific location in the body to maximise drug concentration in a specific tissue or organ, thus improving the drug's therapeutic effectiveness. Microspheres have promised targeted or managed drug distribution in the bo

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Lukova, Paolina, Plamen Katsarov, and Bissera Pilicheva. "Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems." Polymers 15, no. 17 (2023): 3615. http://dx.doi.org/10.3390/polym15173615.

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Micro- and nanotechnologies have been intensively studied in recent years as novel platforms for targeting and controlling the delivery of various pharmaceutical substances. Microparticulate drug delivery systems for oral, parenteral, or topical administration are multiple unit formulations, considered as powerful therapeutic tools for the treatment of various diseases, providing sustained drug release, enhanced drug stability, and precise dosing and directing the active substance to specific sites in the organism. The properties of these pharmaceutical formulations are highly dependent on the

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Gupta, Manish Kumar, Deepak Prakash, and Brahmeshwar Mishra. "Biodegradable microparticulate drug delivery system of diltiazem HCl." Brazilian Journal of Pharmaceutical Sciences 48, no. 4 (2012): 699–709. http://dx.doi.org/10.1590/s1984-82502012000400014.

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The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time. Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic control, fewer side effects, and, consequently, these dosage forms are well accepted by patients. Advances in polymer material science, particle engineering design, manufacture, and nanotechnology have

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Shah, Pervaiz Akhtar, Sajid Bashir, Muhammad Ahsan, Nasir Abbas, Muhammad Zubair Malik, and Hafiz Muhammad Irfan Nazar. "Bioequivalence evaluation of new microparticulate capsule and marketed tablet dosage forms of lornoxicam in healthy volunteers." Tropical Journal of Pharmaceutical Research 15, no. 4 (2016): 877. http://dx.doi.org/10.4314/tjpr.v15i4.30.

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8

Kumar, Tarun, Rimpy Pahwa, and Munish Ahuja. "Grewia asiatica linn. root extract loaded suspension, microparticulate and nanosuspension dosage form: fabrication, characterization and anthelmintic evaluation." ACTA Pharmaceutica Sciencia 60, no. 4 (2022): 363. http://dx.doi.org/10.23893/1307-2080.aps6024.

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Svedberg, Anna, and Tom Lindström. "A pilot web former designed to study retention-formation relationships." Nordic Pulp & Paper Research Journal 25, no. 2 (2010): 185–94. http://dx.doi.org/10.3183/npprj-2010-25-02-p185-194.

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Abstract A pilot-scale fourdrinier former has been developed for the purpose of investigating the relationship between retention and paper formation (features, retention aids, dosage points, etc.). The main objective of this publication was to present the R-F (Retention and formation)-machine and demonstrate some of its fields of applications. For a fine paper stock (90% hardwood and 10% softwood) with addition of 25% filler (based on total solids content), the relationship between retention and formation was investigated for a microparticulate retention aid (cationic polyacrylamide together w

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Ghosh, Amitava, and Prithviraj Chakraborty. "Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide." BioMed Research International 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/819674.

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Objective. Frusemide loaded calcium alginate micropellets, an oral microparticulate delivery system, was statistically optimized exhibiting prolonged therapeutic action minimizing its adverse effects.Methods. Ionotropic Gelation technique was adopted employing 32Factorial designs and keeping the entire process free from organic solvents. Physicochemical and the release characteristics of the prepared formulations were studied, keeping variations only in sodium alginate (primary polymer) and Acrycoat E30D (copolymer) dispersion.Result. Sodium alginate was predominant over Acrycoat E30D in all b

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Soni, Mohnish, Arti Majumdar, and Neelesh Malviya. "MUCOADHESIVE CHITOSAN MICROSPHERES OF GEFITINIB." International Journal of Current Pharmaceutical Research 10, no. 5 (2018): 9. http://dx.doi.org/10.22159/ijcpr.2018v10i5.29686.

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Objective: Gefitinib, Epidermal Growth Factor-Tyrosine Kinase Inhibitor (EGFR-TKI); has promisingly shown activity against Non-Small-Scale Lung Cancer. Currently, the formulations of this drug available are in Tablets, Capsules and liposomal suspensions taken by the oral route. These have certain disadvantages in gastrointestinal disorders like irritation of GI mucosal layer, bleeding, non-patient compliance and low bioavailability due to low aqueous solubility and thus low bioavailability. The purpose of this study was to formulate and evaluate Chitosan-based Microparticles of Gefitinib for m

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Uddin, Mohammad Nasir, Amanda Allon, Monzurul A. Roni, and Samir Kouzi. "Overview and Future Potential of Fast Dissolving Buccal Films as Drug Delivery System for Vaccines." Journal of Pharmacy & Pharmaceutical Sciences 22 (August 5, 2019): 388–406. http://dx.doi.org/10.18433/jpps30528.

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Vaccination is considered one of the most successful public health interventions of the modern era. Vaccines are categorized based on the antigen used, delivery system and the route of administration. Traditional vaccines are produced from the dead, attenuated or inactivated pathogens that cause disease. However, newly developed vaccines are DNA based, liposome based, and virus like particle (VLP) based which are more effective and specific to some malignant diseases. The delivery system of vaccines has been advanced along with time as well. New delivery systems such as nanoparticles, liposome

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Thadanki*, Madhuri Latha. "Formulation and evaluation of sustained release saxagliptin microspheres by ionotropic gelation method." International Journal of Bioassays 6, no. 03 (2017): 5328. http://dx.doi.org/10.21746/ijbio.2017.03.0010.

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The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of an antidiabetic agent, saxagliptin. Saxagliptin microspheres were formulated using sodium alginate as the controlled release polymer by ionotropic gelation technique. The polymer sodium alginate alone and along with different coating polymers like pectin, ethyl cellulose was used in different ratios (1:1,1:1.5, 1:2 ) to formulate batches F1 to F9. The resulting microspheres were evaluated for particle size, densitie

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Alai, Milind, and Wen Jen Lin. "A novel once daily microparticulate dosage form comprising lansoprazole to prevent nocturnal acid breakthrough in the case of gastro-esophageal reflux disease: preparation, pharmacokinetic and pharmacodynamic evaluation." Journal of Microencapsulation 30, no. 6 (2013): 519–29. http://dx.doi.org/10.3109/02652048.2012.758180.

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15

Yamazaki, Moe, Emi Shimamura, Takehisa Hanawa, and Yayoi Kawano. "Microparticulated Mefenamic Acid with High Dispersion Stability for Pediatric Dosage Form." Children 9, no. 6 (2022): 861. http://dx.doi.org/10.3390/children9060861.

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Mefenamic acid (MFA), a water-insoluble drug, is used as a suspension in the medical field, but it requires shaking before using to disperse MFA content in the suspension. In previous studies, trials to prepare MFA suspension with high dispersion stability by atomizing MFA by the wet-milling method. However, HPC is used for atomizing MFA. Therefore, the optimum concentration and molecular weight for atomizing MFA have not been investigated. In this study, we investigated the optimum molecular weight and concentration of HPC for the micronization of MFA. As a result, MFA particles became fine p

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16

Raghuvanshi, Smita, and Kamla Pathak. "Recent Advances in Delivery Systems and Therapeutics of Cinnarizine: A Poorly Water Soluble Drug with Absorption Window in Stomach." Journal of Drug Delivery 2014 (November 13, 2014): 1–15. http://dx.doi.org/10.1155/2014/479246.

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Low solubility causing low dissolution in gastrointestinal tract is the major problem for drugs meant for systemic action after oral administration, like cinnarizine. Pharmaceutical products of cinnarizine are commercialized globally as immediate release preparations presenting low absorption with low and erratic bioavailability. Approaches to enhance bioavailability are widely cited in the literature. An attempt has been made to review the bioavailability complications and clinical therapeutics of poorly water soluble drug: cinnarizine. The interest of writing this paper is to summarize the p

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Ivancic, Albert, Fliur Macaev, Fatma Aksakal, Veaceslav Boldescu, Serghei Pogrebnoi, and Gheorghe Duca. "Preparation of alginate–chitosan–cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds." Beilstein Journal of Nanotechnology 7 (August 24, 2016): 1208–18. http://dx.doi.org/10.3762/bjnano.7.112.

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This paper describes the synthesis and application of alginate–chitosan–cyclodextrin micro- and nanoparticulate systems loaded with isoniazid (INH) and isoconazole nitrate (ISN) as antimycobacterial compounds. Preparation and morphology of the obtained particles, as well as antimycobacterial activity data of the obtained systems are presented. Docking of isoconazole into the active site of enoyl–acyl carrier protein reductase (InhA) of Mycobacetrium tuberculosis was carried out in order to predict the binding affinity and non-covalent interactions stabilizing the InhA–isoconazole complex. To a

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Montagne, P., M. L. Cuillière, E. Marchal та ін. "Application des dosages par immunonéphélémétrie microparticulaire des caséines α, β et Κ à l'évaluation de la qualité du lait, de sa production à sa valorisation fromagère". Le Lait 75, № 3 (1995): 211–37. http://dx.doi.org/10.1051/lait:1995315.

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19

Rafiee, Mona Hassan, and Bazigha K. Abdul Rasool. "An Overview of Microparticulate Drug Delivery System and its Extensive Therapeutic Applications in Diabetes." Advanced Pharmaceutical Bulletin, October 4, 2021. http://dx.doi.org/10.34172/apb.2022.075.

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Microparticulate drug delivery system (MDDS) has attained much consideration in the modern era due to its effectiveness in overcoming traditional treatment problems. Microparticles are spherical particles of a diameter ranging from 10 μm to 1000 μm. Microparticles can encapsulate both water-soluble and insoluble compounds. MDDS proved their efficacy in improving drugs bioavailability, stability, targeting, and controlling their release patterns. Microparticles also offer comfort, easy administration, and improvement in patient compliance by reducing drugs toxicity and dosage frequency. This re

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Kundu, Rajshekhar, Avinab Das, Sourav Maity, Mainak Chakraborty Nilanjan Sarkar, and Swarupananda Mukherjee. "Formulation and evaluation of polymeric microspheres of a poorly soluble drug celecoxib." International journal of health sciences, July 15, 2022. http://dx.doi.org/10.53730/ijhs.v6ns4.10717.

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The aim of this present work was to formulate microspheres of BCS Class II drug Celecoxib. The drug was identified by melting point study and FT-IR spectroscopy. Therapeutic success of a drug is greatly depended on its bioavailability. Majority of the recently discovered drugs shows poor solubility (BCS Class II) which decreases the bioavailability upon oral administration. Microspheres are a novel technique to circumvent this obstacle, which can increase bioavailability of drugs significantly. Polymeric microspheres with Polyvinylpyrrolidone and Eudragit L-100, prepared by Emulsion Solvent Di

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Raja, Pavan M. V., Jennifer Connolley, Lijie Ci, et al. "Interactions of Carbon Nanomaterials With Mammalian Cells." MRS Proceedings 951 (2006). http://dx.doi.org/10.1557/proc-0951-e04-08.

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ABSTRACTDespite their diverse application potential, carbon nanotubes (CNT) have adverse effects in vitro, and in vivo. Previous research has focused on the in vitro cytotoxic impact of CNT aggregates and associated nanoparticulate impurities. In this study, we compared the single-walled carbon nanotube (SWNT) aggregates, and their associated finely dispersed, non-aggregated carbon nanomaterials on rat aortic smooth muscle cells (SMC), through filtration of the aggregates from the CNT-treated cell culture media. In general, our research shows that the removal of single-walled carbon nanotube (

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