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Thematische Bibliographien / Modification / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Modification“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 9. Juni 2025

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1

Rehpenn, Andreas, Alexandra Walter, and Golo Storch. "Molecular Editing of Flavins for Catalysis." Synthesis 53, no. 15 (March 22, 2021): 2583–93. http://dx.doi.org/10.1055/a-1458-2419.

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AbstractThe diverse activity of flavoenzymes in organic transformations has fascinated researchers for a long time. However, when applied outside an enzyme environment, the isolated flavin cofactor only shows largely reduced activity. This highlights the importance of embedding the reactive isoalloxazine core of flavins in defined surroundings. The latter include crucial non-covalent interactions with amino acid side chains or backbone as well as controlled access to reactants such as molecular oxygen. Nevertheless, molecular flavins are increasingly applied in the organic laboratory as valuab

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Song, Ho-Jun. "Advanced Surface Modification Techniques for Enhancing Osseointegration of Titanium Implant." Journal of The Korean Dental Association 48, no. 2 (February 28, 2010): 96–105. http://dx.doi.org/10.22974/jkda.2010.48.2.002.

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Titanium implant is used as the most popular dental material for replacement of missing teeth recently. A lot of studies on the surface modification of titanium implant have been carried out for enhancing osseointegration. The surface modification techniques could be classified as follows; topographic modifications which provide roughness and porosity, chemical surface modificationss or deposition of osseoconductive materials, and biochemical modifications to immobilize bone growth factors on titanium surface. In this study, the current and ongoing surface modification techniques and its typic

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Alrazzaq Ismail, Muhammad Abdul. "MODIFICATION." Journal of Tikrit University for Humanities 29, no. 7, 1 (July 10, 2022): 78–90. http://dx.doi.org/10.25130/jtuh.29.7.1.2022.24.

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This research paper investigates the main features and types of modification. This research paper is clear and easy to read by every student and anyone who wants to develop his knowledge, especially in the modification field. The following research includes an introduction of modification definitions of modification, kinds of modifications, positions of modification forms of modification premodification, and post modification and the conclusion that is gained from this research

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Kato, Yuki, Ken Muramatsu, Yoshinori Yamamoto, Yoshie Suzuki, and Ryo Momosaki. "Strategies for Effective Home Modification in Older Adults." Geriatric Orthopaedic Surgery & Rehabilitation 12 (January 1, 2021): 215145932110207. http://dx.doi.org/10.1177/21514593211020704.

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There are various barriers to home modifications to prevent falls among the older population. Several strategies may be necessary to overcome these barriers and implement effective home modifications. The need for home modification should be assessed, which requires a home evaluation by a specialist. In Japan, welfare housing environment coordinators have been trained to provide advice on home modifications suitable for people with disabilities. In addition, in Japan, home assessment and advice on home modification before discharge from acute care hospitals for older people is allowed as a med

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Kim, Jiseob. "HOW LOAN MODIFICATIONS INFLUENCE THE PREVALENCE OF MORTGAGE DEFAULTS." Macroeconomic Dynamics 21, no. 1 (June 20, 2016): 55–105. http://dx.doi.org/10.1017/s1365100515000395.

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How much can government-driven mortgage modification programs reduce the mortgage default rate? I compare an economy without a modification option to one with easy modifications, and evaluate the impact of these loan modifications on the foreclosure rate. Through loan modification, mortgage servicers can mitigate their losses and households can improve their financial positions without having to walk away from their homes. When modifying loan contracts is prohibitively costly, the default rate increases 1.5 percentage points in response to a 2007-style unexpected drop in housing prices of 30%.

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Eichler, Jerry, and Michael W. W. Adams. "Posttranslational Protein Modification in Archaea." Microbiology and Molecular Biology Reviews 69, no. 3 (September 2005): 393–425. http://dx.doi.org/10.1128/mmbr.69.3.393-425.2005.

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SUMMARY One of the first hurdles to be negotiated in the postgenomic era involves the description of the entire protein content of the cell, the proteome. Such efforts are presently complicated by the various posttranslational modifications that proteins can experience, including glycosylation, lipid attachment, phosphorylation, methylation, disulfide bond formation, and proteolytic cleavage. Whereas these and other posttranslational protein modifications have been well characterized in Eucarya and Bacteria, posttranslational modification in Archaea has received far less attention. Although ar

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Liu, Qi, and Richard I. Gregory. "RNAmod: an integrated system for the annotation of mRNA modifications." Nucleic Acids Research 47, W1 (May 31, 2019): W548—W555. http://dx.doi.org/10.1093/nar/gkz479.

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Abstract Dynamic and reversible RNA modifications such as N6-methyladenosine (m6A) can play important roles in regulating messenger RNA (mRNA) splicing, export, stability and translation. Defective mRNA modification through altered expression of the methyltransferase and/or demethylases results in developmental defects and cancer progression. Identifying modified mRNAs, annotating the distribution of modification sites across the mRNA, as well as characterizing and comparing other modification features are essential for studying the function and elucidating the mechanism of mRNA modifications.

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Belik, Alexei A. "Two Perovskite Modifications of BiFe0.6Mn0.4O3 Prepared by High-Pressure and Post-Synthesis Annealing at Ambient Pressure." Inorganics 12, no. 8 (August 19, 2024): 226. http://dx.doi.org/10.3390/inorganics12080226.

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BiFeO3-related perovskite-type materials attract a lot of attention from the viewpoint of applications and fundamental science. In this work, we prepared two modifications of heavily Mn-doped BiFeO3 with the composition of BiFe0.6Mn0.4O3. A high-pressure (HP) modification was prepared at about 6 GPa and 1400 K. An ambient pressure (AP) modification was prepared by heating the HP modification at 780 K in the air at AP (post-synthesis annealing). Crystal structures of both modifications and in situ transformation were investigated with synchrotron powder X-ray diffraction. The transformation sta

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Zhang, Xiao-Xuan, Yu-Zhe Sun, Wei Wang, Yang Gao, Xin-Yu Wei, Hong-Chao Sun, Chun-Ren Wang, et al. "Altered landscape of total RNA, tRNA and sncRNA modifications in the liver and spleen of mice infected by Toxoplasma gondii." PLOS Neglected Tropical Diseases 18, no. 6 (June 21, 2024): e0012281. http://dx.doi.org/10.1371/journal.pntd.0012281.

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Background Pathogens can impact host RNA modification machinery to establish a favorable cellular environment for their replication. In the present study, we investigated the effect of Toxoplasma gondii infection on host RNA modification profiles and explored how these modifications may influence the host-parasite interaction. Methodology/principal findings We analyzed the modification levels of ∼ 80 nt tRNA and 17–50 nt sncRNAs in mouse liver, spleen, and serum using liquid chromatography and tandem mass spectrometry analysis. The results revealed alterations in RNA modification profiles, par

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Winter, Stefan, and Wolfgang Fischle. "Epigenetic markers and their cross-talk." Essays in Biochemistry 48 (September 20, 2010): 45–61. http://dx.doi.org/10.1042/bse0480045.

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Post-translational modifications of histone proteins in conjunction with DNA methylation represent important events in the regulation of local and global genome functions. Advances in the study of these chromatin modifications established temporal and spatial co-localization of several distinct ‘marks’ on the same histone and/or the same nucleosome. Such complex modification patterns suggest the possibility of combinatorial effects. This idea was originally proposed to establish a code of histone modifications that regulates the interpretation of the genetic code of DNA. Indeed, interdependenc

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Zhou, Ting, and Honghai Liu. "Research Progress of Wood Cell Wall Modification and Functional Improvement: A Review." Materials 15, no. 4 (February 21, 2022): 1598. http://dx.doi.org/10.3390/ma15041598.

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The modification of wood cell walls is based on the characteristics of the chemical composition and structure of the cell wall. Various physical and chemical modifications to these characteristics enhance the original properties of the cell wall and give additional functionality. Through complex modification, wood has also obtained the opportunity to become a multifunctional material. Scholars have paid more attention to the microscopic properties of the cell wall with continuous enrichment of modification methods and improvement of modification mechanisms. This article summarizes the methods

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Zhu, Sucheng, Tao Zheng, Lingxin Kong, Jinli Li, Bo Cao, Michael S. DeMott, Yihua Sun, et al. "Development of Methods Derived from Iodine-Induced Specific Cleavage for Identification and Quantitation of DNA Phosphorothioate Modifications." Biomolecules 10, no. 11 (October 28, 2020): 1491. http://dx.doi.org/10.3390/biom10111491.

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DNA phosphorothioate (PT) modification is a novel modification that occurs on the DNA backbone, which refers to a non-bridging phosphate oxygen replaced by sulfur. This exclusive DNA modification widely distributes in bacteria but has not been found in eukaryotes to date. PT modification renders DNA nuclease tolerance and serves as a constitute element of bacterial restriction–modification (R–M) defensive system and more biological functions are awaiting exploration. Identification and quantification of the bacterial PT modifications are thus critical to better understanding their biological f

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Lin, Hsiang Hsi, Chinwai Lee, F. B. Oswald, and D. P. Townsend. "Computer-Aided Design of High-Contact-Ratio Gears for Minimum Dynamic Load and Stress." Journal of Mechanical Design 115, no. 1 (March 1, 1993): 171–78. http://dx.doi.org/10.1115/1.2919315.

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This paper presents a numerical procedure for minimizing dynamic effects on high-contact-ratio gears by modification of the tooth profile. The paper examines and compares both linear and parabolic tooth profile modifications of high-contact-ratio gears under various loading conditions. The effects of the total amount of modification and the length of the modification zone were systematically studied at various loads and speeds to find the optimum profile design for minimizing the dynamic load and the tooth bending stress. Parabolic profile modification is preferred over linear profile modifica

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Liu, Siyuan, Chaosheng Song, Caichao Zhu, and Qi Fan. "Concave modifications of tooth surfaces of beveloid gears with crossed axes." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 233, no. 4 (April 4, 2018): 1411–25. http://dx.doi.org/10.1177/0954406218768842.

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The mathematical models of the beveloid gear surfaces with different scenarios of combinations of profile concave modification and lead crowning are derived. Four schemes of modifications were proposed for beveloid gears with crossed axes. Tooth contact analysis is developed to study the influences of different schemes of concave modifications on the mesh behaviors including film thickness, transmission errors, contact ratio, root stresses, and contact patterns. Comparison of the contact characteristics of a beveloid gear drive with and without concave modifications is conducted. The results s

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Nazari, Simin, and Amira Abdelrasoul. "Impact of Membrane Modification and Surface Immobilization Techniques on the Hemocompatibility of Hemodialysis Membranes: A Critical Review." Membranes 12, no. 11 (October 28, 2022): 1063. http://dx.doi.org/10.3390/membranes12111063.

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Despite significant research efforts, hemodialysis patients have poor survival rates and low quality of life. Ultrafiltration (UF) membranes are the core of hemodialysis treatment, acting as a barrier for metabolic waste removal and supplying vital nutrients. So, developing a durable and suitable membrane that may be employed for therapeutic purposes is crucial. Surface modificationis a useful solution to boostmembrane characteristics like roughness, charge neutrality, wettability, hemocompatibility, and functionality, which are important in dialysis efficiency. The modification techniques can

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Lee, C. K., C. L. Hsieh, J. C. Ruan, and C. Y. Wang. "Simulation of Meshing of Herringbone Double Circular-Arc Helical Gears using Multibody Dynamic Analysis Software." Journal of Physics: Conference Series 2287, no. 1 (June 1, 2022): 012023. http://dx.doi.org/10.1088/1742-6596/2287/1/012023.

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Abstract This paper aims to complete the simulation of meshing of a pair of herringbone double circular-arc helical gears by using the multibody dynamic analysis software, SolidWorks motion. Three types of edge modifications, including no edge modification, chamfered edge modification, and rounded edge modification, are applied respectively to the pair of gears. The output angular velocities and contact regions corresponding with the three types of edge modifications are analyzed. Moreover, whether the center distance assembly error affects the output angular velocity and contact regions are a

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Dveirin, Oleksandr, Viktor Riabkov, Liudmyla Kapitanova та Danylo Kirnoson. "Методологія формування предметної області модифікаційних змін у важкому транспортному літаку". Aerospace Technic and Technology, № 1 (27 лютого 2023): 4–11. http://dx.doi.org/10.32620/aktt.2023.1.01.

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The subject of study is the process of forming the parameters of modification changes in a heavy transport aircraft. The goal is to develop the subject area of modification changes with the help of design models. The task is to develop models for determining the parameters of modification changes of the base aircraft based on the subject area of the modification project, namely: a model of the decomposition of modification changes of the base aircraft with the selection of parameter levels, which made it possible to apply more reliable assessment methods for different groups of parameters; a m

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Yu, Li Jing, and You Li Feng. "Researching Progress of Zeolite Modification and their Applications in Wastewater Treatment." Applied Mechanics and Materials 66-68 (July 2011): 1260–63. http://dx.doi.org/10.4028/www.scientific.net/amm.66-68.1260.

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Zeolite as a cheap mineral material in industry used in catalytic and environment protection, long time has passed for research on zeolite modification, synthesis and application. In the paper, several modifications for zeolite have been reviewed in detail such as the skeleton element modification, skeleton element modification and zeolite crystals surface modification, modified zeolite properties and application. The shortcomings of the modification methods were pointed out, development and zeolite modification suggestions in the future were put forward.

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Klimenko, Vyacheslav. "Modifications of the work: from written fixation to sounding fact." Muzykal'nyj al'manah Tomskogo gosudarstvennogo universiteta, no. 16 (2023): 26–31. https://doi.org/10.17223/26188929/16/6.

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The article proposes a hypothesis about the presence of two forms, two modifications of the existence of a musical work - a modification of the written recording and a modification of the audio model. If a modification of a written fixation exists only in the text of a work and is understandable only to the performer - a musician, then a modification of the audio model that turns the work into a sounding fact is created by the performer and is available to the listener. It is the change of modifications that ensures the longevity of the work.

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Yuan, Zhe, and Yu Guo. "Approach of Selecting Profile Modifications Curves for Spur Gears." Advanced Materials Research 499 (April 2012): 138–42. http://dx.doi.org/10.4028/www.scientific.net/amr.499.138.

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The tooth profile modification can generally choose straight line modification, parabolic modification and arc modification. In order to accurately determine the tooth profile modification curves, basing on analysis of the vibration that effected by transmission error, a pair of gears meshing process is simulated with FEM approach. Aiming at reducing the fluctuation of transmission error, the transmission error curves of straight line modification, parabolic modification and arc modification with the same modification parameters are plotted, and the best modifications curve is obtained. The re

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Petrulis, Donatas, and Salvinija Petrulyte. "Packing Properties of Fibres in the Open-Packed Yarn Mode." Fibres and Textiles in Eastern Europe 25 (April 30, 2017): 57–61. http://dx.doi.org/10.5604/12303666.1228171.

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Theoretical observations of the packing properties of non-compressible round fibres for two idealized modifications of the open-packed yarn model are discussed. The modifications differ in the method of arrangement of fibres within the cross-sectional ring layer. Modification I has a number of fibres regularly increasing in further layers, and Modification II has the fibres maximum packed in the layers. A procedure for obtaining the number of fibres in the layers of Modification II was proposed. The investigation showed that with the beginning of the 5th layer, the above-mentioned modification

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Marta, Herlina, Ari Rismawati, Giffary Pramafisi Soeherman, Yana Cahyana, Mohamad Djali, Tri Yuliana, and Dewi Sondari. "The Effect of Dual-Modification by Heat-Moisture Treatment and Octenylsuccinylation on Physicochemical and Pasting Properties of Arrowroot Starch." Polymers 15, no. 15 (July 28, 2023): 3215. http://dx.doi.org/10.3390/polym15153215.

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Starch is widely applied in various industrial sectors, including the food industry. Starch is used as a thickener, stabilizer, or emulsifier. However, arrowroot starch generally has weaknesses, such as unstable under heating and acidic conditions, which are generally applied to processing in the food industry. Modifications were applied to improve the characteristics of native arrowroot starch. In this study, arrowroot starch was modified by heat-moisture treatment (HMT), octenylsuccinylation (OSA), and dual modification between OSA and HMT in a different sequence––namely, HMT followed by OSA

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Bensaad, Dhiya Eddine, Mohammed Saleh, Khalid Ismail, and Youngseung Lee. "Recent Advances in Physical, Enzymatic, and Genetic Modifications of Starches." Jordan Journal of Agricultural Sciences 18, no. 3 (September 1, 2022): 245–58. http://dx.doi.org/10.35516/jjas.v18i3.474.

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The current review presents the potential physical modification devised into thermal which includes pre-gelatinization and hydrothermal processing (i.e., annealing (ANN) and heat-moisture treatment (HMT)) and nonthermal modifications (i.e., high-pressure processing (HPP), micronization, ultrasonication, and pulsed electric field (PEF)). Rather than physical modification; enzymatic modification by single enzyme treatment, debranching enzymes, and multienzyme synergetic treatment was discussed. Genetic modification was also discussed as a potential starch modification for better utilization of s

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Spear, Morwenna J., Simon F. Curling, Athanasios Dimitriou, and Graham A. Ormondroyd. "Review of Functional Treatments for Modified Wood." Coatings 11, no. 3 (March 12, 2021): 327. http://dx.doi.org/10.3390/coatings11030327.

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Wood modification is now widely recognized as offering enhanced properties of wood and overcoming issues such as dimensional instability and biodegradability which affect natural wood. Typical wood modification systems use chemical modification, impregnation modification or thermal modification, and these vary in the properties achieved. As control and understanding of the wood modification systems has progressed, further opportunities have arisen to add extra functionalities to the modified wood. These include UV stabilisation, fire retardancy, or enhanced suitability for paints and coatings.

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HAMID, ISSAM A., and MOHAMED ERRADI. "DYNAMIC EVOLUTION OF DISTRIBUTED SYSTEMS SPECIFICATIONS USING REFLECTIVE LANGUAGE." International Journal of Software Engineering and Knowledge Engineering 05, no. 04 (December 1995): 511–40. http://dx.doi.org/10.1142/s0218194095000253.

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Recently, object-oriented specifications of distributed systems has gained more attention. The object-oriented approach is known for its flexibility for system construction. However, one of the major challenges is to provide facilities for the dynamic modifications of such specifications during the development and maintenance process. Yet, current work has not addressed the dynamic modifications of specifications of distributed systems. In this paper, we are concerned with formal description techniques that allow for the development and dynamic modification of executable specifications. A two-

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Phillips, Stacia, Tarun Mishra, Siyu Huang, and Li Wu. "Functional Impacts of Epitranscriptomic m6A Modification on HIV-1 Infection." Viruses 16, no. 1 (January 16, 2024): 127. http://dx.doi.org/10.3390/v16010127.

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Epitranscriptomic RNA modifications play a crucial role in the posttranscriptional regulation of gene expression. N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic RNA and plays a pivotal role in RNA fate. RNA m6A modification is regulated by a group of cellular proteins, methyltransferases (writers) and demethylases (erasers), which add and remove the methyl group from adenosine, respectively. m6A modification is recognized by a group of cellular RNA-binding proteins (readers) that specifically bind to m6A-modified RNA, mediating effects on RNA stability, spli

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Han, Dali, and Meng Michelle Xu. "RNA Modification in the Immune System." Annual Review of Immunology 41, no. 1 (April 26, 2023): 73–98. http://dx.doi.org/10.1146/annurev-immunol-101921-045401.

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Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In this review, we discuss the value of innovative RNA modification profiling technologies to uncover the function of these diverse, dynamic RNA modifications in various immune cells within healthy and diseased contexts. Further, we explore our current understanding of the mechanisms whereby aberrant RNA modifications modulate the immune milieu of the tumor micro

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Li, Tianxing, Xiaotao An, Xiaozhong Deng, Jinfan Li, and Yulong Li. "A New Tooth Profile Modification Method of Cycloidal Gears in Precision Reducers for Robots." Applied Sciences 10, no. 4 (February 13, 2020): 1266. http://dx.doi.org/10.3390/app10041266.

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The tooth profile modification of cycloidal gears is important in the design and manufacture of precision reducers or rotary vector (RV) reducers for robots. The traditional modification design of cycloidal gears is mainly realized by setting various machining parameters, such as the size and center position of the grinding wheel. The traditional modification design has some disadvantages such as complex modification calculation, uncontrollable tooth profile curve shape and unstable meshing performance. Therefore, a new tooth profile modification method is proposed based on the consideration o

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Ding, Hongxu, Andrew D. Bailey, Miten Jain, Hugh Olsen, and Benedict Paten. "Gaussian mixture model-based unsupervised nucleotide modification number detection using nanopore-sequencing readouts." Bioinformatics 36, no. 19 (June 29, 2020): 4928–34. http://dx.doi.org/10.1093/bioinformatics/btaa601.

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Abstract Motivation Nucleotide modification status can be decoded from the Oxford Nanopore Technologies nanopore-sequencing ionic current signals. Although various algorithms have been developed for nanopore-sequencing-based modification analysis, more detailed characterizations, such as modification numbers, corresponding signal levels and proportions are still lacking. Results We present a framework for the unsupervised determination of the number of nucleotide modifications from nanopore-sequencing readouts. We demonstrate the approach can effectively recapitulate the number of modification

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Khairul Anwar Mohd Dahuri, Mohd, Mohd Nasir Hussain, Nor Fasiha Mohd Yusof, and Mohamad Kasim Abdul Jalil. "Preferential factors and usability effects on vehicle modifications for the Malaysian independent disabled driver." International Journal of Engineering & Technology 7, no. 2.29 (May 22, 2018): 781. http://dx.doi.org/10.14419/ijet.v7i2.29.14256.

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The usability of driving modifications for a person with disabilities is known to be an important aspect in addressing the independent vehicle’s driving capabilities. The existence of assistive modifications such as hand control, secondary control, foot control, and also the wheelchair assisted vehicle, which were developed to accommodate limitations were found to be widely used. A survey was conducted on 202 Malaysian independent disabled drivers from Kuala Lumpur, Selangor, Perak, Johor Baharu, Terengganu, and also Melaka. The components evaluated in the survey include the origin of modifica

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Puja, Ign Wiratmaja, Khalid, and S. Weij. "Crash Zone Development for Railway Vehicle." Key Engineering Materials 306-308 (March 2006): 321–26. http://dx.doi.org/10.4028/www.scientific.net/kem.306-308.321.

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This paper considers crash zone development for railway vehicle to improve it’s crashworthiness characteristics. The principle of modification is by weakening the crash zone area and strengthening the passenger area. Thus the huge impact energy during collision will be absorbed by crash zone area so that it will maintain the structural integrity of the passengers. There are two type of modifications proposed in this study. The first modification is conducted by weakening the end-under-frame section and strengthening the middle-under-frame section. These modification shows deformation character

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Novák, Igor, Ivan Michalec, Marian Valentin, Milan Marônek, Ladislav Šoltés, Ján Matyašovský, and Peter Jurkovič. "Steel Surface Modification." Vestnik Volgogradskogo gosudarstvennogo universiteta. Serija 10. Innovatcionnaia deiatel’nost’, no. 3 (October 20, 2014): 47–55. http://dx.doi.org/10.15688/jvolsu10.2014.3.6.

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Schäck, Manfred A., Kim Philipp Jablonski, Stefan Gräf, Roland Klassen, Raffael Schaffrath, Stefanie Kellner, and Christian Hammann. "Eukaryotic life without tQCUG: the role of Elongator-dependent tRNA modifications in Dictyostelium discoideum." Nucleic Acids Research 48, no. 14 (July 1, 2020): 7899–913. http://dx.doi.org/10.1093/nar/gkaa560.

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Abstract In the Elongator-dependent modification pathway, chemical modifications are introduced at the wobble uridines at position 34 in transfer RNAs (tRNAs), which serve to optimize codon translation rates. Here, we show that this three-step modification pathway exists in Dictyostelium discoideum, model of the evolutionary superfamily Amoebozoa. Not only are previously established modifications observable by mass spectrometry in strains with the most conserved genes of each step deleted, but also additional modifications are detected, indicating a certain plasticity of the pathway in the amo

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Meyer, Britta, Carina Immer, Steffen Kaiser, Sunny Sharma, Jun Yang, Peter Watzinger, Lena Weiß, et al. "Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs." Nucleic Acids Research 48, no. 3 (December 21, 2019): 1435–50. http://dx.doi.org/10.1093/nar/gkz1191.

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Abstract tRNAs from all domains of life contain modified nucleotides. However, even for the experimentally most thoroughly characterized model organism Escherichia coli not all tRNA modification enzymes are known. In particular, no enzyme has been found yet for introducing the acp3U modification at position 47 in the variable loop of eight E. coli tRNAs. Here we identify the so far functionally uncharacterized YfiP protein as the SAM-dependent 3-amino-3-carboxypropyl transferase catalyzing this modification and thereby extend the list of known tRNA modification enzymes in E. coli. Similar to t

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Alleyn, Matthew, Mason Breitzig, Richard Lockey, and Narasaiah Kolliputi. "The dawn of succinylation: a posttranslational modification." American Journal of Physiology-Cell Physiology 314, no. 2 (February 1, 2018): C228—C232. http://dx.doi.org/10.1152/ajpcell.00148.2017.

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Posttranslational modifications affect almost all proteins and are critical to a well-functioning and diverse proteome; however, many modifications remain relatively unknown and unstudied. This paper will give a perspective on the rapidly developing, novel posttranslational modification called succinylation. This modification may be implicated in numerous diseases, such as hepatic, cardiac, and pulmonary diseases. Although the influences of this modification still remain poorly understood, we are confident that further research into succinylation will provide an enhanced understanding of the c

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Pongsapan, Allo Sarira, and Rombe Allo. "ANALISIS UNJUK KERJA POMPA SENTRIFUGAL DENGAN PEMASANGAN INDUCER PADA LOCK NUT IMPELLER." Jurnal Teknik AMATA 3, no. 2 (December 3, 2022): 17–25. http://dx.doi.org/10.55334/jtam.v3i2.298.

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Centrifugal pumps are the most widely used fluid machines in our daily life. In operation there are many losses caused by the installation and construction of the pump itself. Many studies have been carried out to minimize these losses, including the research we did, namely in the form of modifications to the centrifugal pump inlet. This study aims to determine the effect of installing the inducer on the locknut impeller on the characteristics of a radial flow type centrifugal pump. Here what is meant by pump characteristics are head, discharge, and pump efficiency. The method used is experime

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Gunka, Volodymyr, Olena Astakhova, Yurii Hrynchuk, Iurii Sidun, Volodymyr Reutskyy, Iryna Mirchuk, and Olha Poliak. "A Review of Road Bitumen Modification Methods. Part 1 – Physical Modification." Chemistry & Chemical Technology 18, no. 2 (June 14, 2024): 295–304. http://dx.doi.org/10.23939/chcht18.02.295.

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The information in this study is based on a thorough review of recent articles related to the production of binders for road construction and the improvement of their performance properties. The main attention is paid to the physical modification of road bitumen with polymer modifiers. The influence of the three main types of polymers (thermoplastics, elastomers, and thermoplastic elastomers) on the main physical and mechanical properties of bitumen-polymer compositions is shown. The main technological parameters and features of the physical modification of bitumen by different types of polyme

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Kohut, Ananiy, Olha Poliak, Iurii Sidun, Olena Astakhova, Artur Onyshchenko, Khrystyna Besaha, and Volodymyr Gunka. "A Review of Road Bitumen Modification Methods. Part 2 - Chemical Modification." Chemistry & Chemical Technology 19, no. 1 (March 25, 2025): 141–56. https://doi.org/10.23939/chcht19.01.141.

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A literature review of modern chemical methods for modifying road bitumen has been conducted, focusing on their popularity and the nature of their impact on binder properties. Sulfur, polyphosphoric acid, maleic anhydride, thermosetting resins (such as phenol-formaldehyde, epoxy, polyester, etc.), and polymers are the most commonly used chemical modifiers in road construction practices. The method of producing bituminous materials with varying penetration levels through the chemical modification of oil residues with formaldehyde has been considered. All bituminous materials produced via chemic

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Kim, Geon-Woo, and Aleem Siddiqui. "Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs." Proceedings of the National Academy of Sciences 118, no. 3 (January 4, 2021): e2019455118. http://dx.doi.org/10.1073/pnas.2019455118.

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Chronic hepatitis B virus (HBV) infections are one of the leading causes of cirrhosis and hepatocellular carcinoma. N6-methyladenosine (m6A) modification of cellular and viral RNAs is the most prevalent internal modification that occurs cotranscriptionally. Previously, we reported the dual functional role of m6A modification of HBV transcripts in the viral life cycle. Here, we show that viral HBV X (HBx) protein is responsible for the m6A modifications of viral transcripts. HBV genomes defective in HBx failed to induce m6A modifications of HBV RNAs during infection/transfection, while ectopic

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Meza, Rosemary D., Nathaniel Jungbluth, Georganna Sedlar, Prerna Martin, Lucy Berliner, Shannon Wiltsey-Stirman, and Shannon Dorsey. "Clinician-Reported Modification to a CBT Approach in Children’s Mental Health." Journal of Emotional and Behavioral Disorders 28, no. 2 (February 13, 2019): 104–13. http://dx.doi.org/10.1177/1063426619828369.

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Examining the nature and determinants of evidence-based treatment (EBT) modification is an important step toward understanding the impact of modifications and informing modification guidelines. We examined the prevalence, types, reasons for, and predictors of clinician-reported modification to cognitive behavioral therapy (CBT) for children and adolescents. Ninety-eight clinicians trained in CBT completed surveys on their intent to modify CBT, perceptions of CBT characteristics, confidence in their ability to appropriately deliver CBT in complex clinical situations, and organizational EBT impl

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Subroto, Edy, Yana Cahyana, Rossi Indiarto, and Tiara Aray Rahmah. "Modification of Starches and Flours by Acetylation and Its Dual Modifications: A Review of Impact on Physicochemical Properties and Their Applications." Polymers 15, no. 14 (July 9, 2023): 2990. http://dx.doi.org/10.3390/polym15142990.

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Various modification treatments have been carried out to improve the physicochemical and functional properties of various types of starch and flour. Modification by acetylation has been widely used to improve the quality and stability of starch. This review describes the effects of acetylation modification and its dual modifications on the physicochemical properties of starch/flour and their applications. Acetylation can increase swelling power, swelling volume, water/oil absorption capacity, and retrogradation stability. The dual modification of acetylation with cross-linking or hydrothermal

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Mao, Shuangshuang, Zuhua Chen, Yingying Wu, Huihua Xiong, and Xianglin Yuan. "Crosstalk of Eight Types of RNA Modification Regulators Defines Tumor Microenvironments, Cancer Hallmarks, and Prognosis of Lung Adenocarcinoma." Journal of Oncology 2022 (July 11, 2022): 1–19. http://dx.doi.org/10.1155/2022/1285632.

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RNA modification has become an exciting underexplored field in recent years. In lung adenocarcinoma (LUAD), m6A was the best characterized and most studied RNA modification, while knowledge about other kinds of RNA modifications in LUAD is limited. In our study, we included a total of 100 RNA modification regulators of eight types of cancer-related RNA modifications (m6A, m1A, m5C, Nm, m7G, Ψ, A-to-I, and mcm5s2U) to systematically profile their specific roles in LUAD. By gene mutation and expression analysis, we identified extensive dysregulations and complicated interactions of 100 RNA modif

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TUHVATULLIN, Midhat, Yuri ARKHANGELSKY, Rustam AIPOV, and Eduard KHASANOV. "Innovations in designing microwave electro-technological units with hybrid chambers." Spanish Journal of Agricultural Research 21, no. 1 (February 23, 2023): e0202. http://dx.doi.org/10.5424/sjar/2023211-19683.

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Aim of study: Microwave (MW) electro-technological units based on electromagnetic radiation of ultrahigh-frequency can involve thermal MW modification of dielectrics and non-thermal MW modification of polymers.  Area of study: Russian Federation. Material and methods: The paper considers a method for making a unit with a hybrid chamber, where thermal and non-thermal MW modifications were carried out simultaneously, and the remaining energy after non-thermal MW modification of polymers was used for heating the dielectric.  Main results: A microwave electro-technological unit w

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Froese, Vincent, Leon Kellerhals, and Rolf Niedermeier. "Modification-Fair Cluster Editing." Proceedings of the AAAI Conference on Artificial Intelligence 36, no. 6 (June 28, 2022): 6631–38. http://dx.doi.org/10.1609/aaai.v36i6.20617.

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The classic Cluster Editing problem (also known as Correlation Clustering) asks to transform a given graph into a disjoint union of cliques (clusters) by a small number of edge modifications. When applied to vertex-colored graphs (the colors representing subgroups), standard algorithms for the NP-hard Cluster Editing problem may yield solutions that are biased towards subgroups of data (e.g., demographic groups), measured in the number of modifications incident to the members of the subgroups. We propose a modification fairness constraint which ensures that the number of edits incident to each

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Yang, Weiwei, Alexey Fomenkov, Dan Heiter, Shuang-yong Xu, and Laurence Ettwiller. "High-throughput sequencing of EcoWI restriction fragments maps the genome-wide landscape of phosphorothioate modification at base resolution." PLOS Genetics 18, no. 9 (September 19, 2022): e1010389. http://dx.doi.org/10.1371/journal.pgen.1010389.

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Phosphorothioation (PT), in which a non-bridging oxygen is replaced by a sulfur, is one of the rare modifications discovered in bacteria and archaea that occurs on the sugar-phosphate backbone as opposed to the nucleobase moiety of DNA. While PT modification is widespread in the prokaryotic kingdom, how PT modifications are distributed in the genomes and their exact roles in the cell remain to be defined. In this study, we developed a simple and convenient technique called EcoWI-seq based on a modification-dependent restriction endonuclease to identify genomic positions of PT modifications. Ec

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PEGO, MATHEUS, JANAÍNA CARVALHO, and DAVID GUEDES. "SURFACE MODIFICATIONS OF ACTIVATED CARBON AND ITS IMPACT ON APPLICATION." Surface Review and Letters 26, no. 01 (January 2019): 1830006. http://dx.doi.org/10.1142/s0218625x1830006x.

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The main and new surface modification methods of activated carbon (AC) and their influence on application (adsorption capacity) were reviewed. Adsorption capacity is an important issue, contributing to hazardous substances environment management. According to literature, it is true that surface chemistry strongly affects adsorption capacity. Surface chemistry can be modified by several methods that lead to different activated carbon properties. Furthermore, adsorbate properties, and their relationships with surface structure, can impact adsorption properties. Surface modifications can be condu

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Marta, Herlina, Hana Nur Layalia Hasya, Zahra Indah Lestari, Yana Cahyana, Heni Radiani Arifin, and Siti Nurhasanah. "Study of Changes in Crystallinity and Functional Properties of Modified Sago Starch (Metroxylon sp.) Using Physical and Chemical Treatment." Polymers 14, no. 22 (November 10, 2022): 4845. http://dx.doi.org/10.3390/polym14224845.

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Sago starch has weaknesses such as low thermal stability and high syneresis. Modifications were made to improve the characteristics of native sago starch. In this study, sago starch was modified by autoclave-heating treatment (AHT), osmotic-pressure treatment (OPT), octenyl-succinic anhydride modification (OSA), and citric acid cross-linking (CA). This study aimed to examine the changes in chemical composition, crystallinity, and functional properties of the native sago starch after physical and chemical modifications. The results show that physical modification caused greater granule damage t

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Glans, M., S. Bejerot, and J. Dossou Nilsson. "Tattooing and piercing are associated with symptoms of ADHD: A cross-sectional study of non-clinical adults." European Psychiatry 65, S1 (June 2022): S84—S85. http://dx.doi.org/10.1192/j.eurpsy.2022.255.

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Introduction Previous studies suggest that individuals with tattoos and piercings exhibit higher impulsive personality traits compared to peers without body modifications. No studies on body modifications and core-symptoms of ADHD are available. Objectives This study aimed to compare self-reported ADHD symptoms between non-clinical adults with and without body modifications. Methods A non-clinical adult Swedish population (n=815) completed the Adult ADHD self-report scale (ASRS-v1.1) and answered questions concerning body modification. ADHD diagnosis served as exclusion criterion. Three groupi

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DeZern, Amy E., Gary Binder, Albert Fliss, X. Henry Hu, Syed Rizvi, Frank A. Corvino, Steven R. Arikian, Andy Surinach, Jianyi Lee, and B. Douglas Smith. "Relationship Between Lenalidomide Dose Modification and Outcomes in Patients with Myelodysplastic Syndromes." Blood 126, no. 23 (December 3, 2015): 3286. http://dx.doi.org/10.1182/blood.v126.23.3286.3286.

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Abstract Introduction: In clinical studies of patients (pts) with International Prognostic Scoring System (IPSS)-defined Low- to Intermediate-1-risk myelodysplastic syndromes (MDS), dose modification of lenalidomide (LEN) has been commonly used by physicians to sustain control of disease while managing toxicities. A previous real-world setting analysis has shown that dose modification of LEN in pts with multiple myeloma was associated with longer duration of therapy (DOT) and improved outcomes versus pts without dose modification (Usmani SZ, et al. Blood. 2014;124:abstract 2655). This study ai

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Lee, Chinwai, Hsiang Hsi Lin, Fred B. Oswald, and Dennis P. Townsend. "Influence of Linear Profile Modification and Loading Conditions on The Dynamic Tooth Load and Stress of High-Contact-Ratio Spur Gears." Journal of Mechanical Design 113, no. 4 (December 1, 1991): 473–80. http://dx.doi.org/10.1115/1.2912807.

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This paper presents a computer simulation for the dynamic response of high-contact-ratio spur gear transmissions. High contact ratio gears have the potential to produce lower dynamic tooth loads and minimum root stress but they can be sensitive to tooth profile errors. The analysis presented in this paper examines various profile modifications under realistic loading conditions. The effect of these modifications on the dynamic load (force) between mating gear teeth and the dynamic root stress is presented. Since the contact stress is dependent on the dynamic load, minimizing dynamic loads will

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