Auswahl der wissenschaftlichen Literatur zum Thema „Multicompartmental nanoparticles“

Mesoporous silica nanoparticles (MSNs) are promising functional nanomaterials for a variety of biomedical applications, such as bioimaging, drug/gene delivery, and cancer therapy. This is due to their low density, low toxicity, high biocompatibility, large specific surface areas, and excellent thermal and mechanical stability. The past decade has seen rapid advances in the development of MSNs with multiple compartments. These include hierarchical porous structures and core-shell, yolk-shell, and Janus structured particles for efficient diagnosis and therapeutic applications. We review advances in this area, covering the categories of multicompartment MSNs and their synthesis methods, with an emphasis on hierarchical structures and the incorporation of multiple functions. We classify multicompartment mesoporous silica micro/nanostructures, ranging from core-shell and yolk-shell structures to Janus and raspberry-like nanoparticles, and discuss their synthesis methods. We review applications of these multicompartment MSNs, including bioimaging, targeted drug/gene delivery, chemotherapy, phototherapy, and in vitro diagnostics. We also highlight the latest trends and new opportunities.

Synthesis of thermo-responsive ABC triblock terpolymer nano-objects by seeded RAFT polymerization is achieved. At temperature above LCST, the triblock terpolymer nano-objects convert into multicompartment nanoparticles.

We report an unusual self-assembly behavior driven by a tiny terminal alkynyl end group in fully hydrophilic homopolymers which form multicompartment vesicles and flower-like nanoparticles in aqueous solution.

The solution-phase self-assembly or “polymerization” of discrete colloidal building blocks, such as “patchy” nanoparticles and multicompartment micelles, is attracting growing attention with respect to the creation of complex hierarchical materials.

Les nanoparticules Janus (JNP) asymétriques innovantes à base de lipides développées à l'Institut Galien peuvent servir de nouveaux vecteurs de délivrance de médicaments ou de transporteur d'agents diagnostiques dans le domaine des nanotechnologies. Pour obtenir ce type de particules anisotropes, différentes matières premières (phospholipides et tensioactifs à base de PEG courts ou dérivés amphiphiles de cyclodextrines) et méthodes de préparation (homogénéisation haute pression à chaud ou nanoprécipitation) ont été comparées. Ensuite, nous avons essayé d'optimiser ces JNP, en termes à la fois de connaissance sur l'influence des phospholipides et de la composition de la phase aqueuse. La relation entre la morphologie des JNP et la nature des phospholipides a été établie notamment en considérant le paramètre d'empilement de ces derniers. Des informations complémentaires ont pu être obtenues par l'étude de l'interaction entre les phospholipides et les tensioactifs à PEG courts constitutifs des JNP.L'encapsulation de deux substances actives modèles, ayant des solubilités opposées, a ensuite été évaluée et comparée à d'autres nanodispersions lipidiques comme les liposomes. La libération de ces molécules modèles a également été suivie et modélisée. Enfin, le dernier objectif a été d'explorer la toxicité aiguë des JNP sur des larves de poissons zèbre. Notamment, les images de microscopie à fluorescence ont montré que la biodistribution des nanoparticules est très cohérente avec la nanotoxicité et les malformations identifiées chez les larves.Ce projet confirme que les assemblages supramoléculaires asymétriques sont des candidats prometteurs pour la co-encapsulation d'ingrédients pharmaceutiques actifs hydrophiles et hydrophobes
The innovative asymmetric lipid-based Janus nanoparticles (JNPs) developed by the Galien Institute can function as novel drug delivery vehicles or diagnostic agent carriers in the field of nanotechnology. To obtain this type of anisotropic particles, different raw materials (phospholipids and short-PEG-based surfactants or amphiphilic cyclodextrin derivatives) and preparation methods (hot high-pressure homogenization or nanoprecipitation) were compared. After that, we tried to optimize these JNPs in terms of knowledge of phospholipid effects and aqueous phase composition. Especially, the relationship between JNP morphology and phospholipid properties was established by considering the packing parameter of phospholipids. By investigating the interaction between phospholipids and short-PEG-based surfactants that constitute JNP, more information can be obtained.We are interested in the ability of classical Janus NPs to co-encapsulate the model drug pairs, and the dual phase release kinetics are quantified and adjusted by mathematic equations. Finally, we aim to explore the acute toxicity and morphological changes upon exposure to classical Janus NPs on the zebrafish larvae. Moreover, the fluorescence microscopy images showed that the biodistribution of nanoparticles is pretty consistent with the nanotoxicity and malformations determined in the larvae. This project verified that the multicompartmental supramolecular organizations are promising candidates for the co-encapsulation of the hydrophilic and hydrophobic active pharmaceutical ingredients