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Thematische Bibliographien / Multidrug nanoparticles / Dissertationen

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Dissertationen zum Thema „Multidrug nanoparticles“

Autor: Grafiati

Veröffentlicht am 29. März 2025

Zuletzt aktualisiert am 31. Juli 2025

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Trần, Natalie Lan Linh. "Innovative multidrug nanomedicines for the treatment of myocardial ischemia/ reperfusion injuries." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ073.

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L'ischémie/ reperfusion cardiaque est une condition pathologique complexe impliquant divers mécanismes de signalisation. En raison de leurs interactions, les traitements disponibles pour les lésions de reperfusion sont souvent insuffisants. Il est donc crucial d'explorer des approches intégrantes plusieurs agents ciblant différentes voies biologiques. Bien que la nanomédecine offre des opportunités pour protéger les principes actifs et optimiser le ciblage thérapeutique, elle fait face à des défis tels qu'un faible taux d'incorporation des médicaments. La méthode de squalenoylisation pourrait

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Vlerken, Lilian Emilia van. "Modulation of multidrug resistance in cancer using polymer-blend nanoparticles : thesis /." Diss., View dissertation online, 2008. http://hdl.handle.net/2047/d10017355.

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Taute, C. J. F. "Tumour specific targeted in vitro theranostics application of fabricated nanostructures in a multi-drug resistant ovarian carcinoma cell line." Thesis, University of the Western Cape, 2013. http://hdl.handle.net/11394/4530.

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Philosophiae Doctor - PhD<br>Ovarian cancer is called the “Silent Killer” as it is often diagnosed in advanced stages of the disease or misdiagnosed which ends with a poor prognostic outcome for the patient. A high rate of disease relapse, a high incidence-to-mortality ratio as well as acquired multidrug resistance makes it necessary to find alternative diagnostic- and therapeutic tools for ovarian cancer. Nanotechnology describes molecular devices with at least one dimension in the sub- 1μm scale and has been suggested as a possible solution for overcoming challenges in cancer multidrug resis

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Sen, Gulseren Petek. "Fabrication Of Poly (dl-lactic-co-glycolic Acid) Nanoparticles And Synthetic Peptide Drug Conjugate For Anti-cancer Drug Delivery." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12611405/index.pdf.

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Cancer is a group of diseases in which normal cells are converted to cells capable of autonomous growth and invasion. In the chemotherapeutic control of cancer, drugs are usually given systemically so they reach toxic levels in healthy cells as well as cancer cells. This causes serious side effects. Another important problem with chemotherapy is resistance developed to cytotoxic drugs (multi drug resistance). Doxorubicin (Dox) occupies a central position in the treatment of breast cancer. However doxorubicin induced cardiac toxicity is associated with a high incidence of morbidity and mortali

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Wan, Chung Ping Leon. "The effect of P-glycoprotein inhibition and ultrasound exposure on the cytotoxicity of taxane loaded diblock copolymer nanoparticles in multidrug resistant cells." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/49957.

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One of the major mechanisms of multidrug resistance involves an efflux protein, P-glycoprotein (Pgp), which pumps commonly used anticancer drugs such as taxanes out of cells, leading to a decrease in cellular drug accumulation. The overall goal of this project was to develop strategies to enhance intracellular drug accumulation and cytotoxicity of nanoparticulate taxanes in multi-drug resistant (MDR) cell lines. Paclitaxel (PTX) loaded nanoparticles fabricated from micelle forming MePEG₁₁₄-b-PCL₁₉ and nanosphere forming MePEG₁₁₄-b-PCL₁₀₄ were compared for drug and block copolymer uptake, and c

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Ngema, Xolani Terrance. "Metallic nanoparticles with polymeric shell: A multifunctional platform for application to biosensor." University of the Western Cape, 2018. http://hdl.handle.net/11394/6330.

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Philosophiae Doctor - PhD (Chemistry)<br>Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (MTB) that usually affects the lungs leading to severe coughing, fever and chest pains. It was estimated that over 9.6 million people worldwide developed TB and 1.5 million died from the infectious disease of which 12 % were co-infected with human immunodeficiency virus (HIV) in the year 2015. In 2016 the statistics increased to a total of 1.7 million people reportedly died from TB with an estimated 10.4 million new cases of TB diagnosed worldwide. The development of the effic

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Dormont, Flavio. "Development of nanomedicines for inflammation disorders : evaluation of pharmacological efficacy on preclinical models Nanomedicines for the management of Sepsis Nanoplumbers: Biomaterials to fight cardiovascular diseases Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation Translation of Nanomedicines from Lab to Industrial Scale Synthesis: The Case of Squalene-Adenosine Nanoparticles." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS451.

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Les syndromes inflammatoires, marqués par une réaction excessive du système immunitaire, sont associés à de nombreuses conditions pathologiques comme le sepsis, les accidents d’ischémie/reperfusion ou l’athérosclérose. En effet, une réponse inflammatoire excessive à l’encontre des tissus caractérise souvent l’apparition et la pathophysiologie de ces maladies complexes pour lesquelles ils manquent toujours des traitements efficaces. Ainsi, la plupart des thérapies disponibles pour adapter la réponse inflammatoire sont limitées la plupart du temps par des effets secondaires indésirables, une mau

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Carrasco, Letícia Dias de Melo. "Arrranjos supramoleculares de lípide catiônico, antibióticos e polímeros: preparação, caracterização e atividade contra bactérias multirresistentes e micobactérias de crescimento rápido." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04082016-092804/.

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Arranjos supramoleculares combinando o lípide catiônico brometo de dioctadecildimetilamônio (DOD) com polímeros, como carboximetilcelulose (CMC) e cloreto de poli(dialildimetilamônio) (PDDA), foram preparados na forma de nanopartículas (NPs), na ausência ou presença de antimicrobiano tradicional, como a claritromicina (CLA). NPs preparadas por atração eletrostática entre os fragmentos de bicamada (BF) de DOD, CMC e PDDA foram avaliadas, in vitro, quanto à atividade contra isolados clínicos de micro-organismos multirresistentes (MR) a antimicrobianos, como Pseudomonas aeruginosa MR, Klebsiella

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Dreaden, Erik Christopher. "Chemistry, photophysics, and biomedical applications of gold nanotechnologies." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/51320.

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Gold nanoparticles exhibit a combination of physical, chemical, optical, and electronic properties unique from all other nanotechnologies. These structures can provide a highly multifunctional platform with which to diagnose and treat diseases and can dramatically enhance a variety of photonic and electronic processes and devices. The work herein highlights some newly emerging applications of these phenomena as they relate to the targeted diagnosis and treatment of cancer, improved charge carrier generation in photovoltaic device materials, and strategies for enhanced spectrochemical analysis

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Hsiao, Jui-Pin, and 蕭睿彬. "Development of nanoparticles with chemotherapeutic/siRNA dual functions against multidrug-resistant cancer cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/20319311035879470789.

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碩士<br>臺灣大學<br>醫學工程學研究所<br>98<br>To realize gene therapy and chemotherapy in multi-drug-resistant cancer cell, we develop carriers which can co-delivery gene and chemotherapy drug. The mPEG-PCL-PEI (M510i) tri-block polymers were synthesized by use mMPEG-PCL copolymer modified to PEI. The characteristic of these tri-block polymers were evaluated by 1H nuclear magnetic resonance and gel permeation chromatography. The critical micelle concentration (CMC) of micelle was evaluated by using pyrene as fluorescence probe. The particle size, zeta potential, and morphology of micelle was studied by dyna

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Pereira, Carolina Correia de Figueiredo Abreu. "Nanomedicines, a strategy to evade multidrug resistance." Master's thesis, 2015. http://hdl.handle.net/10362/16341.

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Multidrug resistance is a major problems associated with cancer chemotherapy. Efflux transports is one of the numerous mechanisms involved in multidrug resistance. P-glycoprotein is a transmembrane protein, responsible for drug efflux, which decreases drugs intracellular bioavailability, consequently decreasing their efficacy against cancer. Cancer growth and dissemination depends on the expression of transcriptional factors such as, Twist. Among other features, this protein is related with cells chemoresistance possible by regulation of multidrug resistance pathways including the P-glycoprote

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Fragoso, Ana Sofia Fernandes. "Nanosized delivery systems for fluoroquinolones: a review and practical case formulation in the setting of multidrug-resistant bacteria." Master's thesis, 2019. http://hdl.handle.net/10316/88297.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>A resistência bacteriana apresenta-se nos dias de hoje como uma ameaça constante, com impacto não só ao nível da saúde da comunidade global como também na economia dos países. A ineficácia das quinolonas apresenta especial importância, uma vez que esta classe de antibióticos ocupa um lugar de destaque constituindo uma escolha comum de antibiotrapia.Com este trabalho pretende-se sistematizar os melhores métodos de produção, com vista à obtenção de características físico-químicas otimizada

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(6875918), Lu Lin. "I. ANTIMICROBIAL PHOTODYNAMIC INACTIVATION TARGETING MULTIDRUG RESISTANCE WITH GALLIUM-HEMOGLOBIN-COATED SILVER NANOPARTICLES II. SYNTHESIS AND PROPERTIES OF MAGNETIC GOLD NANOPARTICLES." Thesis, 2019.

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<p>I. Gallium-hemoglobin Coated Silver Nanoparticles for Antimicrobial Photodynamic Therapy Against Bacterial Pathogens One of the mechanisms for bacterial pathogens’ hemin acquisition is through cell-surface hemin receptors (CSHRs), which are responsible for rapid hemin recognition. GaPpIX, as a hemin analog, can be rapidly taken up by CSHR-expressing bacteria, such as <i>Staphylococcus aureus</i> (<i>S.aureus)</i>. Previous works shown that GaPpIX has aPDI activity at micromolar level of concentration following 10 seconds of 405-nm light exposure using LED array. The photosensitizing ability

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Chen, Hsin-Hung, and 陳信宏. "Biodegradable Nanoparticles Coated with PEG-Derivative for Improving Therapeutic Efficacy against Multidrug Resistance Cancer Cells." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/52456903495928899963.

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博士<br>國立中興大學<br>化學工程學系所<br>105<br>In recent years, nanotechnology has been used for the development of drug delivery system for cancer therapy. Those nanocarriers can effectively accumulate in the tumor site via the enhanced permeability and retention (EPR) effect. However, multidrug resistance (MDR) is frequently encountered in patients undergoing long-term chemotherapy, leading to the failure of chemotherapy. One of the well-known mechanisms of MDR is drug efflux mediated by permeability glycoprotein (P-gp). The MDR cancer cells overexpress the P-gp on their cell membrane and efflux the drug

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Chen, Yung-Tsung, and 陳詠宗. "In-vitro cytotoxicity of Doxorubicin-Loaded mPEG-b-(PCL)2 Micellar Nanoparticles Against Multidrug Resistant Human Breast Cancer Cell Lines." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/62091428004755907091.

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碩士<br>中原大學<br>奈米科技碩士學位學程<br>97<br>Cancer multidrug resistance is associated with plasma membrane expression of P-glycoprotein which results to a reduction of the intracellular drug concentration after activation of P-glycoprotein efflux. In this study, an AB2 type amphiphilic block copolymer was synthesized from biodegradable methoxy poly (ethylene glycol) (mPEG) and poly (ε-caprolactone) (PCL) to encapsulate the antitumor drug, Doxorubicin (DOX). The initiator mPEG was first esterified with 2,2-bis (hydroxymethyl) butyric acid. Removal of the protective group by acidic resin afforded a copoly

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Wong, Ho-Lun. "A study of nanoparticle drug carrier for treatment of multidrug-resistant breast cancer with loco-regional involvement." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=449962&T=F.

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