Zeitschriftenartikel: „Nicotinate“

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&NA;. „Xantinol nicotinate“. Reactions Weekly &NA;, Nr. 1301 (Mai 2010): 53. http://dx.doi.org/10.2165/00128415-201013010-00188.

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2

Ravikumar, K., G. Y. S. K. Swamy, B. Sridhar und S. Roopa. „Olazipinium nicotinate“. Acta Crystallographica Section E Structure Reports Online 61, Nr. 8 (27.07.2005): o2720—o2723. http://dx.doi.org/10.1107/s160053680502369x.

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3

Duncan, Kimbell, und Yuichiro Suzuki. „Vitamin E Nicotinate“. Antioxidants 6, Nr. 1 (13.03.2017): 20. http://dx.doi.org/10.3390/antiox6010020.

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4

Jennings, D. S., P. B. Brevard, J. A. Flohr und J. W. Gloeckner. „Chromium Nicotinate Supplementation“. Journal of the American Dietetic Association 97, Nr. 9 (September 1997): A65. http://dx.doi.org/10.1016/s0002-8223(97)00541-5.

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5

Balasubramani, Kasthuri, Packianathan Thomas Muthiah, Gabriele Bocelli und Andrea Cantoni. „Pyrimethaminium nicotinate monohydrate“. Acta Crystallographica Section E Structure Reports Online 63, Nr. 11 (26.10.2007): o4452. http://dx.doi.org/10.1107/s1600536807052397.

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In the title compound, C12H14ClN4 +·C6H4NO2 −·H2O, the pyrimethamine molecule is protonated at one of the pyrimidine N atoms. The protonated N atom and 2-amino group of the cation interact with an adjacent nicotinate anion through a pair of N—H...O hydrogen bonds [graph set R 2 2(8)]. The cation, anion and water molecule form a hydrogen-bonded ring motif with graph-set notation R 4 2(8). The crystal structure is further stabilized by N—H...O and O—H...O hydrogen bonds and π–π interactions [centroid–centroid distance = 3.637 (6) Å].

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Mehl, Ryan A., Cynthia Kinsland und Tadhg P. Begley. „Identification of the Escherichia coliNicotinic Acid Mononucleotide Adenylyltransferase Gene“. Journal of Bacteriology 182, Nr. 15 (01.08.2000): 4372–74. http://dx.doi.org/10.1128/jb.182.15.4372-4374.2000.

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ABSTRACT The gene (ybeN) coding for nicotinate mononucleotide adenylyltransferase, an NAD(P) biosynthetic enzyme, has been identified and overexpressed in Escherichia coli. This enzyme catalyzes the reversible adenylation of nicotinate mononucleotide and shows product inhibition. The rate of adenylation of nicotinate mononucleotide is at least 20 times faster than the rate of adenylation of nicotinamide mononucleotide.

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GOPAL, Elangovan, You-Jun FEI, Seiji MIYAUCHI, Lina ZHUANG, Puttur D. PRASAD und Vadivel GANAPATHY. „Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family“. Biochemical Journal 388, Nr. 1 (10.05.2005): 309–16. http://dx.doi.org/10.1042/bj20041916.

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SMCT (sodium-coupled monocarboxylate transporter; slc5a8) is a Na+-coupled transporter for lactate, pyruvate and short-chain fatty acids. Similar to these already known substrates of SMCT, the water-soluble B-complex vitamin nicotinic acid also exists as a monocarboxylate anion (nicotinate) under physiological conditions. Therefore we evaluated the ability of SMCT to mediate the uptake of nicotinate. In mammalian cells, the cloned mouse SMCT (slc5a8) induced the uptake of nicotinate. The SMCT-induced uptake was Na+-dependent. The Michaelis constant for the uptake process was 296±88 μM. The Na+-activation kinetics indicated that at least two Na+ ions are involved in the process. Among the various structural analogues tested, nicotinate was the most effective substrate. Nicotinamide and methylnicotinate were not recognized by the transporter. 2-Pyrazine carboxylate and isonicotinate interacted with the transporter to a moderate extent. SMCT-mediated uptake of nicotinate was inhibited by lactate and pyruvate. In the Xenopus laevis oocyte expression system, SMCT-mediated nicotinate transport was electrogenic, as evident from the nicotinate-induced inward currents under voltage-clamp conditions. Substrate-induced currents in this expression system corroborated the substrate specificity determined in the mammalian cell expression system. The kinetic parameters with regard to the affinity of the transporter for nicotinate and the Hill coefficient for Na+ activation, determined by using the oocyte expression system, were also similar to those obtained from the mammalian cell expression system. We conclude that SMCT functions not only as a Na+-coupled transporter for short-chain fatty acids and lactate but also as a Na+-coupled transporter for the water-soluble vitamin nicotinic acid.

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Trunov, Konstantin S., Anton P. Danilenko, Vladimir M. Pokrovsky, Anna A. Peresypkina, Vladislav O. Soldatov, Elena A. Konovalova, Lyudmila M. Danilenko, Tatyana A. Denisuk, Sergey V. Povetkin und Nina I. Zhernakova. „Endothelioprotective Impact of 2-Ethyl-3-Hydroxy-6-Methylpyridine Nicotinate“. Journal of Computational and Theoretical Nanoscience 17, Nr. 9 (01.07.2020): 4746–50. http://dx.doi.org/10.1166/jctn.2020.9372.

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A main issue in pharmacology is the seek for effective agents for the correction of ED. To study the endothelioprotective effects of 2-ethyl-3-hydroxy-6-methylpyridinium (2e3h6m) nicotinate under conditions of L-NAME-induced oxidation. The L-NAME pattern of induced oxide efficiency (25 mg/g) for one week was used. The endothelial and cardioprotective effect of 2e3h6m nicotinate at an amount of 3.75 mg/kg compared to picamilon 10 mg/kg was examined via the coefficient of ED (QED) and a number of exercise tests. Nicotinate 2e3h6m and picamilon exerted a pronounced endothelioprotective impact on the pattern of L-NAME-induced NO deficiency, which manifested itself in a decrease in the coefficient of endothelial dysfunction (ED). At the same time, 2e3h6m nicotinate (7.6 mg/kg) was 2.1 times more effective than picamilon (10 mg/kg). So, 2e3h6m nicotinate was produced itself as an endothelio and cardioprotector.

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Ámon, Judit, Rafael Fernández-Martín, Eszter Bokor, Antonietta Cultrone, Joan M. Kelly, Michel Flipphi, Claudio Scazzocchio und Zsuzsanna Hamari. „A eukaryotic nicotinate-inducible gene cluster: convergent evolution in fungi and bacteria“. Open Biology 7, Nr. 12 (Dezember 2017): 170199. http://dx.doi.org/10.1098/rsob.170199.

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Nicotinate degradation has hitherto been elucidated only in bacteria. In the ascomycete Aspergillus nidulans , six loci, hxnS /AN9178 encoding the molybdenum cofactor-containing nicotinate hydroxylase, AN11197 encoding a Cys2/His2 zinc finger regulator HxnR, together with AN11196/ hxnZ , AN11188/ hxnY , AN11189/ hxnP and AN9177/ hxnT , are clustered and stringently co-induced by a nicotinate derivative and subject to nitrogen metabolite repression mediated by the GATA factor AreA. These genes are strictly co-regulated by HxnR. Within the hxnR gene, constitutive mutations map in two discrete regions. Aspergillus nidulans is capable of using nicotinate and its oxidation products 6-hydroxynicotinic acid and 2,5-dihydroxypyridine as sole nitrogen sources in an HxnR-dependent way. HxnS is highly similar to HxA, the canonical xanthine dehydrogenase (XDH), and has originated by gene duplication, preceding the origin of the Pezizomycotina. This cluster is conserved with some variations throughout the Aspergillaceae. Our results imply that a fungal pathway has arisen independently from bacterial ones. Significantly, the neo-functionalization of XDH into nicotinate hydroxylase has occurred independently from analogous events in bacteria. This work describes for the first time a gene cluster involved in nicotinate catabolism in a eukaryote and has relevance for the formation and evolution of co-regulated primary metabolic gene clusters and the microbial degradation of N -heterocyclic compounds.

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Zhang, Lili, Jianwei Zheng, Xin Tie, Tong Lin, Wanqi Yang, Ziqing Li, Yong Zou et al. „Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1“. Canadian Journal of Physiology and Pharmacology 99, Nr. 9 (September 2021): 900–909. http://dx.doi.org/10.1139/cjpp-2020-0583.

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Vascular endothelial cell senescence is a leading cause of age-associated diseases and cardiovascular diseases. Interventions and therapies targeting endothelial cell senescence and dysfunction would have important clinical implications. This study evaluated the effect of 10 resveratrol analogues, including pterostilbene (Pts) and its derivatives, against endothelial senescence and dysfunction. All the tested compounds at the concentrations from 10−9 M to 10−6 M did not show cytotoxicity in endothelial cells by MTT assay. Among the 10 resveratrol analogues, Pts and Pts nicotinate attenuated the expression of senescence-associated β-galactosidase, downregulated p21 and p53, and increased the production of nitric oxide (NO) in both angiotensin II – and hydrogen peroxide – induced endothelial senescence models. In addition, Pts and Pts nicotinate elicited endothelium-dependent relaxations, which were attenuated in the presence of endothelial NO synthase (eNOS) inhibitor L-NAME or sirtuin 1 (SIRT1) inhibitor sirtinol. Pts and Pts nicotinate did not alter SIRT1 expression but enhanced its activity. Both Pts and Pts nicotinate have high binding activities with SIRT1, according to surface plasmon resonance results and the molecular docking analysis. Inhibition of SIRT1 by sirtinol reversed the anti-senescent effects of Pts and Pts nicotinate. Moreover, Pts and Pts nicotinate shared similar ADME (absorption, distribution, metabolism, excretion) profiles and physiochemical properties. This study suggests that the Pts and Pts nicotinate ameliorate vascular endothelial senescence and elicit endothelium-dependent relaxations via activation of SIRT1. These two compounds may be potential drugs for the treatment of cardiovascular diseases related to endothelial senescence and dysfunction.

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Rodionova, Irina A., Harmon J. Zuccola, Leonardo Sorci, Alexander E. Aleshin, Marat D. Kazanov, Chen-Ting Ma, Eduard Sergienko, Eric J. Rubin, Christopher P. Locher und Andrei L. Osterman. „Mycobacterial Nicotinate Mononucleotide Adenylyltransferase“. Journal of Biological Chemistry 290, Nr. 12 (28.01.2015): 7693–706. http://dx.doi.org/10.1074/jbc.m114.628016.

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Teramoto, Haruhiko, Masako Suda, Masayuki Inui und Hideaki Yukawa. „Regulation of the Expression of Genes Involved in NAD De Novo Biosynthesis in Corynebacterium glutamicum“. Applied and Environmental Microbiology 76, Nr. 16 (02.07.2010): 5488–95. http://dx.doi.org/10.1128/aem.00906-10.

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ABSTRACT Three genes, nadA, nadB, and nadC, involved in NAD de novo biosynthesis are broadly conserved in the genomes of numerous bacterial species. In the genome of Corynebacterium glutamicum, nadA and nadC but not nadB are annotated. The nadA and nadC genes are located in a gene cluster containing two other genes, designated ndnR and nadS herein. ndnR encodes a member of the Nudix-related transcriptional regulator (NrtR) family. nadS encodes a homologue of cysteine desulfurase involved in Fe-S cluster assembly. The gene cluster ndnR-nadA-nadC-nadS is genetically characterized herein. Mutant strains deficient in nadA, nadC, or nadS required exogenous nicotinate for growth, and the nicotinate auxotrophy was complemented by introduction of the corresponding gene in trans, indicating that each of these genes is essential for growth in the absence of an exogenous source of NAD biosynthesis. The results of reverse transcriptase PCR analyses and ndnR promoter-lacZ expression analyses revealed that the expression of ndnR, nadA, nadC, and nadS genes was markedly and coordinately repressed by nicotinate. The expression of these genes was enhanced by the disruption of ndnR, resulting in the loss of the nicotinate-responsive regulation of gene expression. These results suggest that NdnR acts as a transcriptional repressor of NAD de novo biosynthesis genes and plays an essential role in the regulation of the response to nicotinate.

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Matsui, Ayu, und Hiroshi Ashihara. „Nicotinate riboside salvage in plants: Presence of nicotinate riboside kinase in mungbean seedlings“. Plant Physiology and Biochemistry 46, Nr. 1 (Januar 2008): 104–8. http://dx.doi.org/10.1016/j.plaphy.2007.10.008.

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Chuck, Roderick. „Technology development in nicotinate production“. Applied Catalysis A: General 280, Nr. 1 (Februar 2005): 75–82. http://dx.doi.org/10.1016/j.apcata.2004.08.029.

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Hemamalini, Madhukar, und Hoong-Kun Fun. „2-Amino-5-methylpyridinium nicotinate“. Acta Crystallographica Section E Structure Reports Online 66, Nr. 3 (20.02.2010): o662. http://dx.doi.org/10.1107/s1600536810005970.

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Lafforgue, C. „Percutaneous absorption of methyl nicotinate“. International Journal of Pharmaceutics 121, Nr. 1 (06.07.1995): 89–93. http://dx.doi.org/10.1016/0378-5173(95)00010-g.

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M. Elsawi, Nagwa, Wejdan A. Aldajani, Mounir A. A. Mohamed, Ahmed M. Ali, Gamal S.A, Soad Shaker Ali und Sabra A. Abd El lah. „Copper (I) Nicotinate complex Abrogates Acrylamide Induced Hepatotoxicity in Male Rats: Biochemical and Histological Studies“. International Journal of Food and Nutritional Science 6, Nr. 1 (25.04.2019): 21–31. http://dx.doi.org/10.15436/2377-0619.19.2416.

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This study was conducted as a trail to abrogates acrylamide induced hepatotoxicity in male rats by administration of copper (I) nicotinic acid complex. Animals were divided into 4 groups ;GI: control kept on balanced diet and tap water , GII: Acrylamide group received acrylamide in drinking water (7.5 mg/kg b.w.) for 30 days. GIII: treated with copper (I)-nicotinate complex (400 μg/kg b.w.) after acrylamide intoxication for 30 days and GIV the complex then acrylamide (prophylactic). Results showed significant increase in serum levels of AST, ALT, ALP, GGT and total antioxidant capacity (TAC) in acrylamide group. Moreover a significant increase in tumer markers AFU and TNF-Alpha. while Levels of each of S. total protein and S. albumin were significantly decreased in ACR group compared with control. Histological study showed congestion of central vein in liver section and vacuolation of hepatocytes in ACR group. Anticancer activity using in-vitro cytotoxic assay of Cu (I) Nicotinate complex ; proves the anticancer properties of it comparing with doxorubicin. Treatment with Copper (I)-Nicotinate Complex restored tissue and serological indices concomitantly towards normal levels. These results revealed that Copper (I)-Nicotinate Complex is able to significantly alleviate the hepatotoxicity induced by AA in rats and could be utilized as a potent food additives.

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Cobo, Justo, Christopher Glidewell, John N. Low und Fabían Orozco. „Ethyl 2-methoxy-6-[(triphenylphosphoranylidene)amino]nicotinate and ethyl 2-methylsulfanyl-6-[(triphenylphosphoranylidene)amino]nicotinate“. Acta Crystallographica Section C Crystal Structure Communications 64, Nr. 4 (20.03.2008): o233—o236. http://dx.doi.org/10.1107/s0108270108006963.

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Szabłowicz, Małgorzta, und Ewa Kita. „New chromium(III)–nicotinate complexes. Kinetics and mechanism of nicotinate ligand liberation in acidic media“. Transition Metal Chemistry 30, Nr. 5 (August 2005): 623–29. http://dx.doi.org/10.1007/s11243-005-4588-z.

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Timmons, James A., Simon M. Poucher, Dumitru Constantin-Teodosiu, Ian A. Macdonald und Paul L. Greenhaff. „Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction“. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274, Nr. 5 (01.05.1998): R1384—R1389. http://dx.doi.org/10.1152/ajpregu.1998.274.5.r1384.

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Pyruvate dehydrogenase complex (PDC) activation status has been described as being central in the regulation of tissue substrate oxidation as outlined by the glucose fatty-acid cycle. In the present study we examined the effects of reduced lipolysis, with use of nicotinate, and increased PDC activation, with use of dichloroacetate (DCA), on substrate utilization during 20 min of submaximal steady-state contraction (∼80% of maximal O2uptake) in canine gracilis skeletal muscle. At rest, PDC activation was unchanged by nicotinate but was ∼2.5-fold higher in the DCA group than in the control group ( P < 0.05). During contraction, PDC activation status increased to 3.5 mmol acetyl-CoA ⋅ min−1 ⋅ kg−1at 37°C in the control group, remained at 4.5 mmol acetyl-CoA ⋅ min−1 ⋅ kg−1at 37°C in the DCA group, but only increased to 2.2 mmol acetyl-CoA ⋅ min−1 ⋅ kg−1at 37°C in the nicotinate group ( P< 0.05). However, the estimated amount of carbohydrate oxidized during the 20-min contraction was similar across groups and did not follow the degree of PDC activation (81.2 ± 22.9, 95.9 ± 11.7, and 89.3 ± 18.9 mmol glucosyl units/kg dry muscle for control, nicotinate, and DCA, respectively). Thus it would appear that, during steady-state contraction, PDC activation status does not determine the rate of carbohydrate oxidation in skeletal muscle.

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Moore, H. D., und F. M. Cunningham. „Mediators of increased blood flow in porcine skin“. Mediators of Inflammation 1, Nr. 1 (1992): 55–59. http://dx.doi.org/10.1155/s0962935192000115.

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Nicotinates and benzalkonium chloride (B.Cl) cause inflammatory changes in human skin, thought to be dependent upon prostaglandin formation. This study has examined the effects of hexyl-nicotinate (HN) and B.Cl on blood flow in porcine skin. The role of prostaglandins and interleukin (IL)-1 in the blood flow response has been investigated. Blood flow was increased by both HN and B.Cl, the response to B.Cl being more protracted. Cyclooxygenase inhibitor pretreatment reduced these responses. IL-1-like biological activity was identified in normal porcine epidermis and the amounts recovered from inflamed skin were similar. Thus prostaglandin formation in HN or B.Cl-induced inflammation, if IL-1 dependent, is not associated with the loss of significant amounts of the cytokine from the epidermis.

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Peresypkina, Anna, Anton Pazhinsky, Lyudmila Danilenko, Sergey Lugovskoy, Mikhail Pokrovskii, Evgeniya Beskhmelnitsyna, Nikolai Solovev et al. „Retinoprotective Effect of 2-Ethyl-3-hydroxy-6-methylpyridine Nicotinate“. Biology 9, Nr. 3 (28.02.2020): 45. http://dx.doi.org/10.3390/biology9030045.

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An important task of pharmacology is to find effective agents to improve retinal microcirculation and resistance to ischemia. The purpose of the study is to pharmacologically evaluate the retinoprotective effect of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate in a rat model of retinal ischemia–reperfusion. A retinal ischemia–reperfusion model was used, in which an increase in intraocular pressure (IOP) to 110 mmHg was carried out within 30 min. The retinoprotective effect of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate at a dose of 3.8 mg/kg, in comparison with nicotinic acid at a dose of 2 mg/kg and emoxipine at a dose of 2 mg/kg, was estimated by the changes in the eye fundus during ophthalmoscopy, the retinal microcirculation level with laser Doppler flowmetry (LDF), and electroretinography (ERG) after 72 h of reperfusion. The use of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate prevented the development of ischemic injuries in the fundus and led to an increase in the retinal microcirculation level to 747 (median) (lower and upper quartiles: 693;760) perfusion units (p = 0.0002) in comparison with the group that underwent no treatment. In the group with the studied substance, the b-wave amplitude increased significantly (p = 0.0022), and the b/a coefficient increased reliably (p = 0.0002) in comparison with the group with no treatment. Thus, 2-ethyl-3-hydroxy-6-methylpyridine nicotinate has established itself as a potential retinoprotector.

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Kim, Galina A., Tamara S. Gan’shina, Elena V. Kurza, Ilya N. Kurdyumov, Denis V. Maslennikov und Ruben S. Mirzoian. „New cerebrovascular agent with hypotensive activity“. Research Results in Pharmacology 5, Nr. 2 (27.06.2019): 71–77. http://dx.doi.org/10.3897/rrpharmacology.5.35392.

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Introduction: In cerebrovascular disorders, special attention is paid to a hypertensive cerebrovascular crisis, which combines a vascular injury of the brain and hypertension. The paper studies the cerebrovascular properties of the calcium channel blocker of S-Amlodipine nicotinate antihypertensive agent. Materials and methods: Tests were performed on 96 nonlinear male rats, measuring local blood flow in the cerebral cortex in 36 awake animals, using a laser Doppler flowmeter. Cerebral circulation was recorded in the animals when modeling ischemic and hemorrhagic brain injuries. Results and discussion: S-Amlodipine nicotinate (0.1 mg/kg i/v) shows a pronounced cerebrovascular activity in the models of ischemic and hemorrhagic injuries of the brain. In terms of the vasodilating effect in ischemic brain injury, the drug is comparable to mexidol, nimodipine, picamilon, but is superior to nimodipine and picamilon in terms of duration of action, and in the model of hemorrhagic stroke, S-Amlodipine nicotinate is superior to nimodipine and is comparable to picamilon and mexidol. The analysis of the mechanism of action of the agent revealed the participation of GABA A-receptors in the implementation of cerebrovascular properties of the agent. Conclusion: Significant cerebrovascular activity of S-Amlodipine nicotinate (0.1 mg/kg i/v) antihypertensive agent was revealed. The presence of GABAergic mechanism on cerebral blood flow in the agent action along with blockade of slow calcium channels ensures its high efficacy in treatment of both ischemic and hemorrhagic brain injuries.

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Sharutin, V. V., A. P. Pakusina, T. P. Platonova, O. K. Sharutina, A. V. Gerasimenko, D. Yu Popov und M. A. Pushilin. „Synthesis and Structure of Tetraphenylantimony Nicotinate“. Russian Journal of General Chemistry 74, Nr. 2 (Februar 2004): 207–10. http://dx.doi.org/10.1023/b:rugc.0000025501.29625.ff.

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Martinez-Vargas, Sergio, Arturo I. Martinez, Jesús Valdés-Martínez und Dale L. Perry. „Preparation of three new 4′-phenyl-terpyridine–copper(II) complexes containing nicotinate or iso-nicotinate ligands“. Journal of Molecular Structure 1033 (Februar 2013): 34–39. http://dx.doi.org/10.1016/j.molstruc.2012.08.030.

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Heck, Immanuel S., Joseph D. Schrag, Joan Sloan, Lindsey J. Millar, Ghassan Kanan, James R. Kinghorn und Shiela E. Unkles. „Mutational Analysis of the Gephyrin-Related Molybdenum Cofactor Biosynthetic Gene cnxE From the Lower Eukaryote Aspergillus nidulans“. Genetics 161, Nr. 2 (01.06.2002): 623–32. http://dx.doi.org/10.1093/genetics/161.2.623.

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Abstract We report the identification of a number of mutations that result in amino acid replacements (and their phenotypic characterization) in either the MogA-like domain or domains 2 and 3 of the MoeA-like region of the Aspergillus nidulans cnxE gene. These domains are functionally required since mutations that result in amino acid substitutions in any one domain lead to the loss or to a substantial reduction in all three identified molybdoenzyme activities (i.e., nitrate reductase, xanthine dehydrogenase, and nicotinate hydroxylase). Certain cnxE mutants that show partial growth with nitrate as the nitrogen source in contrast do not grow on hypoxanthine or nicotinate. Complementation between mutants carrying lesions in the MogA-like domain or the MoeA-like region, respectively, most likely occurs at the protein level. A homology model of CnxE based on the dimeric structure of E. coli MoeA is presented and the position of inactivating mutations (due to amino acid replacements) in the MoeA-like functional region of the CnxE protein is mapped to this model. Finally, the activity of nicotinate hydroxylase, unlike that of nitrate reductase and xanthine dehydrogenase, is not restored in cnxE mutants grown in the presence of excess molybdate.

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Jornet-Mollá, Verónica, Carlos Giménez-Saiz und Francisco Romero. „Synthesis, Structure, and Photomagnetic Properties of a Hydrogen-Bonded Lattice of [Fe(bpp)2]2+ Spin-Crossover Complexes and Nicotinate Anions“. Crystals 8, Nr. 11 (21.11.2018): 439. http://dx.doi.org/10.3390/cryst8110439.

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In this paper, we report on the synthesis, crystal structure, and photomagnetic properties of the spin-crossover salt of formula [Fe(bpp)2](C6H4NO2)2·4H2O (1·4H2O) (bpp = 2,6-bis(pyrazol-3-yl)pyridine; C6H4NO2− = nicotinate anion). This compound exhibits a 3D supramolecular architecture built from hydrogen bonds between iron(II) complexes, nicotinate anions, and water molecules. As synthesized, the hydrated material is low-spin and desolvation triggers a low-spin (LS) to high-spin (HS) transformation. Anhydrous phase 1 undergoes a partial spin crossover (T1/2= 281 K) and a LS to HS photomagnetic conversion with a T(LIESST) value of 56 K.

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Xu, Chao, Sheng-Bo Liu, Taike Duan, Qun Chen und Qian-Feng Zhang. „Syntheses, Structures and Photoluminescent Properties of the Two Novel Coordination Polymers [Cd(pydc)2(tu)]n and [Cd2(SO4)(nic)2(tu)1.5(H2O)2]n (pydc = Pyridine-2,3-dicarboxylate, nic = Nicotinate, tu = Thiourea)“. Zeitschrift für Naturforschung B 66, Nr. 5 (01.05.2011): 459–64. http://dx.doi.org/10.1515/znb-2011-0504.

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Two novel cadmium coordination polymers, [Cd(pydc)2(tu)]n (1) and [Cd2(SO4)(nic)2(tu)1.5 - (H2O)2]n (2) (pydc = pyridine-2,3-dicarboxylate, nic = nicotinate, tu = thiourea), have been synthesized under hydrothermal conditions and structurally characterized by X-ray diffraction analysis. 1 is a one-dimensional ladder coordination polymer in a two-dimensional network formed by hydrogen bonds. 2 consists of two kinds of Cd(II) centers in different coordination environments connected via nicotinate and sulfate to form a two-dimensional grid network integrated in a three-dimensional framework generated by hydrogen bonds. 2 shows intense fluorescent emission in the solid state at room temperature

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Erharuyi, O., I. Igbe, A. Falodun, R. Enadeghe und O. Igbinedion. „Synthesis and antinociceptive activity of methyl nicotinate“. Journal of Pharmacy & Bioresources 12, Nr. 1 (21.05.2015): 54. http://dx.doi.org/10.4314/jpb.v12i1.8.

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Bleaney, B., M. J. M. Leask, M. G. Robinson, M. R. Wells und C. A. Hutchison. „Enhanced nuclear magnetic resonance in holmium nicotinate“. Journal of Physics: Condensed Matter 2, Nr. 8 (26.02.1990): 2009–14. http://dx.doi.org/10.1088/0953-8984/2/8/007.

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Chang, Wei-Jie, Padi Yi-Syong Su und Kwang-Ming Lee. „Anion-controlled supramolecular crystal structures and ionic liquids from fatty acid-substituted ethyl-nicotinate ionic compounds“. CrystEngComm 20, Nr. 45 (2018): 7248–55. http://dx.doi.org/10.1039/c8ce00785c.

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Wasson, Anna E., und Robert L. LaDuca. „Hydrothermal synthesis, crystal structures, and properties of two 3-D network nickel nicotinate coordination polymers: [Ni4(μ-H2O)2(nicotinate)8·2H2O] and [Ni2(H2O)2(nicotinate)4(4,4′-bpy)]“. Polyhedron 26, Nr. 5 (März 2007): 1001–11. http://dx.doi.org/10.1016/j.poly.2006.09.069.

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Toma, Monica, Agustín Sánchez, María García-Tasende, José Casas, José Sordo, Eduardo Castellano und Javier Ellena. „Crystal structure and spectral characterization of dimethylthallium (III) complexes with 2-mercaptonicotinic acid and esters“. Open Chemistry 2, Nr. 3 (01.09.2004): 534–52. http://dx.doi.org/10.2478/bf02476206.

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AbstractSynthesis, spectral properties and crystal structure of dimethylthallium(III) complexes with 2-mercaptonicotinic acid (2mna), 2-mercapto-methyl-nicotinate (2mmn), 2-mercapto-ethyl-nicotinate (2men) and 2-mercapto-isopropyl-nicotinate (2min) are reported. The compounds were characterized using IR, multinuclear NMR (1H,13C,205Tl) and mass spectrometry (electrospray, ES-API). The molecular structures of [TlMe2(2mna)]·H2O, (1), [TlMe2(2mmn)], (2), [TlMe2(2men)], (3) and [TlMe2(2min)], (4) were determined by the single-crystal X-ray diffraction. In 1, the monodeprotonate O,S-bidentate ligand chelates one dimethylthallium (III) unit and simultaneously bridges (O and S) between two of these organometallic units. The Tl-O1′ and Tl-S″ interactions are leading to polymeric chain linked in a three-dimensional network by the hydrogen bonds formed between the water molecule and the oxygen O (2) atom of the acid. The thallium atom is in a distorted octahedral environment with a [TlC2O2S2] kernel. Compounds 2, 3 and 4 are similar, in all the cases already mentioned the ligand is NH deprotonated and is strongly coordinated to two dimethylthallium (III) units through the N and S atoms. Two additional weak interactions with the O and S atoms lead to a [TlC2NOS2] kernel for the metal atom, in which the coordination polyhedron is a very distorted octahedron with the methyl groups occupying the apical positions.

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Dahal, Akriti Shree, Roshani Tuitui, Purna Devi Shrestha, Bharati Sharma, Sharada Acharya und Priyanka Dahal. „Effectiveness of Glycerin Magnesium Sulphate Versus Heparin Benzyl Nicotinate Application Among Children with Phlebitis“. Journal of Nepal Paediatric Society 40, Nr. 1 (10.08.2020): 21–27. http://dx.doi.org/10.3126/jnps.v40i1.28659.

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Introduction: Phlebitis is the most common complication of intravenous infusion therapy. Incidence of phlebitis in children receiving intravenous therapy has been reported to be as high as 71.25%. The study was done to find out the effectiveness of glycerin magnesium sulphate versus heparin benzyl nicotinate application in children with phlebitis. Methods: A pre-post control group design was used. A total of 43 subjects were randomly assigned into two groups [22 in experimental (glycerin magnesium sulphate application) and 21 in control (heparin benzyl nicotinate application) group] by lottery method. Data was collected using Modified Visual Infusion Phlebitis (VIP) Score. Results: The comparison between VIP score was based on observations made before the interventions and at 12, 24, 36 and 48 hours after the intervention. Independent t tests showed significant difference in reduction of VIP score in experimental and control group after 12 hours and 24 hours of intervention. The study demonstrated that there is no statistically significant difference in reduction of VIP score among the subjects in experimental and control group at 12 hours (p = 0.219), 24 hours (p = 0.349), 36 hours (p = 0.695) and 48 hours (p = 0.424) after the intervention. Conclusion: The study concludes that both glycerin magnesium sulphate and heparin benzyl nicotinate can be used effectively among children with phlebitis. However, after 24 hours of phlebitis, an alternative intervention needs to be used.

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Ahmed, H. A., M. Hagar und O. A. Alhaddad. „New chair shaped supramolecular complexes-based aryl nicotinate derivative; mesomorphic properties and DFT molecular geometry“. RSC Advances 9, Nr. 29 (2019): 16366–74. http://dx.doi.org/10.1039/c9ra02558h.

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A new series of chair-shaped liquid crystalline complexes were formed through 1 : 1 intermolecular hydrogen bonding between 4-(4-(hexyloxyphenylimino)methyl)phenyl nicotinate and 4-alkoxybenzoic acids, with different alkoxy chains.

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Yeh, Chun-Wei, Maw-Cherng Suen, Hui-Ling Hu, Jhy-Der Chen und Ju-Chun Wang. „Synthesis and structural characterization of two new chiral coordination polymers of Cu(nicotinate)2(H2O) and Co(nicotinate)2“. Polyhedron 23, Nr. 11 (Juli 2004): 1947–52. http://dx.doi.org/10.1016/j.poly.2004.04.026.

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Rayner, Peter J., Michael J. Burns, Alexandra M. Olaru, Philip Norcott, Marianna Fekete, Gary G. R. Green, Louise A. R. Highton, Ryan E. Mewis und Simon B. Duckett. „Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange“. Proceedings of the National Academy of Sciences 114, Nr. 16 (04.04.2017): E3188—E3194. http://dx.doi.org/10.1073/pnas.1620457114.

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Hyperpolarization turns typically weak NMR and MRI responses into strong signals so that ordinarily impractical measurements become possible. The potential to revolutionize analytical NMR and clinical diagnosis through this approach reflect this area's most compelling outcomes. Methods to optimize the low-cost parahydrogen-based approach signal amplification by reversible exchange with studies on a series of biologically relevant nicotinamides and methyl nicotinates are detailed. These procedures involve specific 2H labeling in both the agent and catalyst and achieve polarization lifetimes of ca. 2 min with 50% polarization in the case of methyl-4,6-d2-nicotinate. Because a 1.5-T hospital scanner has an effective 1H polarization level of just 0.0005% this strategy should result in compressed detection times for chemically discerning measurements that probe disease. To demonstrate this technique’s generality, we exemplify further studies on a range of pyridazine, pyrimidine, pyrazine, and isonicotinamide analogs that feature as building blocks in biochemistry and many disease-treating drugs.

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Marcocci, Lucia, und Yuichiro J. Suzuki. „Metabolomics Studies to Assess Biological Functions of Vitamin E Nicotinate“. Antioxidants 8, Nr. 5 (11.05.2019): 127. http://dx.doi.org/10.3390/antiox8050127.

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Vitamin E nicotinate (tocopherol nicotinate, tocopheryl nicotinate; TN) is an ester of two vitamins, tocopherol (vitamin E) and niacin (vitamin B3), in which niacin is linked to the hydroxyl group of active vitamin E. This vitamin E ester can be chemically synthesized and is used for supplementation. However, whether TN is formed in the biological system was unclear. Our laboratory previously detected TN in rat heart tissues, and its level was 30-fold lower in a failing heart (Wang et al., PLoS ONE 2017, 12, e0176887). The rat diet used in these experiments contained vitamin E acetate (tocopherol acetate; TA) and niacin separately, but not in the form of TN. Since only TN, but not other forms of vitamin E, was decreased in heart failure, the TN structure may elicit biologic functions independent of serving as a source of active vitamin E antioxidant. To test this hypothesis, the present study performed metabolomics to compare effects of TN on cultured cells to those of TA plus niacin added separately (TA + N). Human vascular smooth muscle cells were treated with TN or with TA + N (100 μM) for 10 min. Metabolite profiles showed that TN and TA + N influenced the cells differentially. TN effectively upregulated various primary fatty acid amides including arachidonoylethanoamine (anandamide/virodhamine) and palmitamide. TN also activated mitogen-activated protein kinases. These results suggest a new biological function of TN to elicit cell signaling.

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Danilenko, Lyudmila M. „Doxorubicin-associated Cardiomyopathy: New Approaches to Pharmacological Correction Using 3-(2,2,2-trimethylhydrazinium) Propionate Derivatives“. Research Results in Pharmacology 4, Nr. 1 (28.03.2018): 81–86. http://dx.doi.org/10.3897/rrpharmacology.4.25530.

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Introduction: The search for new compounds with cardioprotective activity amongst the 3-(2,2,2-trimethylhydrazinium) propionate derivatives looks promising. Research objectives: to study cardioprotective effects of the 3-(2,2,2-trimethylhydrazinium) propionate derivatives. Methods: The cardioprotective effect of the derivatives (nicotinate, 5-hydroxynicotinate) of 3-(2,2,2-trimethylhydrazinium) propionate) and reference medicine meldonium in the case of doxorubicin (DOX) (20 mg/kg, intraperitoneally for 48 hours) cardiomyopathy was evaluated by the results of a functional test with high-frequency stimulation (480 bpm). To provide integral validation for the development of the simulated pathological processes, biochemical and morphological studies of the heart were carried out. For a biochemical evaluation of myocardial damage in the homogenisate, the isoenzyme creatinine kinase MB (CK-MB) and lactate dehydrogenase (LDH) were determined. Results: The derivatives nicotinate and 5-hydroxynicotinate of 3-(2,2,2-trimethylhydrazinium) propionate) exert a cardioprotective effect on a doxorubicin pathology model, which is expressed in a decreased coefficient of diastolic dysfunction (StTTI) to the level of 5.8±0.1 ru and 4.6±0.2 ru in comparison with that in the control group 8.3±0.1 ru and reference medicine meldonium 6.5±0.1 ru, respectively. The cardioprotective effect was confirmed by decreased levels of markers of damage to CK-MB and LDH and a decreased diameter of cardiomyocytes compared to those in the control group. Conclusion: The derivatives of 3-(2,2,2-trimethylhydrazinium) propionate (nicotinate, 5-hydroxynicotinate) 3-(2,2,2-trimethylhydrazinium) propionate reduce diastolic dysfunction and irreversible damage to cardiomyocytes in case of doxorubicin-associated cardiomyopathy.

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Breslow, Ronald, und Radhika Batrd. „The Radical Relay Chlorination of Fleible Nicotinate Esters“. HETEROCYCLES 28, Nr. 1 (1989): 23. http://dx.doi.org/10.3987/com-88-s8.

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MBAH, CJ. „Degradation kinetics of benzyl nicotinate in aqueous solution“. Indian Journal of Pharmaceutical Sciences 72, Nr. 1 (2010): 46. http://dx.doi.org/10.4103/0250-474x.62238.

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Hollanders, Karlijn, Evelien Renders, Charlène Gadais, Dario Masullo, Laurent Van Raemdonck, Clarence C. D. Wybon, Charlotte Martin, Wouter A. Herrebout, Bert U. W. Maes und Steven Ballet. „Zn-Catalyzed Nicotinate-Directed Transamidations in Peptide Synthesis“. ACS Catalysis 10, Nr. 7 (10.02.2020): 4280–89. http://dx.doi.org/10.1021/acscatal.9b05074.

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Palusiak, Marcin. „4-(E)-But-1-enyl-2,6-dimethoxyphenyl nicotinate“. Acta Crystallographica Section E Structure Reports Online 59, Nr. 6 (23.05.2003): o854—o856. http://dx.doi.org/10.1107/s1600536803010766.

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Kitts, C. L., J. P. Lapointe, V. T. Lam und R. A. Ludwig. „Elucidation of the complete Azorhizobium nicotinate catabolism pathway.“ Journal of Bacteriology 174, Nr. 23 (1992): 7791–97. http://dx.doi.org/10.1128/jb.174.23.7791-7797.1992.

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Shin, Dong Hae, Natalia Oganesyan, Jaru Jancarik, Hisao Yokota, Rosalind Kim und Sung-Hou Kim. „Crystal Structure of a Nicotinate Phosphoribosyltransferase fromThermoplasma acidophilum“. Journal of Biological Chemistry 280, Nr. 18 (06.03.2005): 18326–35. http://dx.doi.org/10.1074/jbc.m501622200.

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Stringasci, Mirian Denise, Heloísa Ciol, Renan Arnon Romano, Hilde Harb Buzza, Ilaiáli Souza Leite, Natalia Mayumi Inada und Vanderlei Salvador Bagnato. „MAL-associated methyl nicotinate for topical PDT improvement“. Journal of Photochemistry and Photobiology B: Biology 213 (Dezember 2020): 112071. http://dx.doi.org/10.1016/j.jphotobiol.2020.112071.

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Siddiqui, Kafeel Ahmad, und Gopal K. Mehrotra. „Zn-nicotinate complex – a precursor for ZnO nanoparticles“. Journal of Coordination Chemistry 66, Nr. 10 (01.05.2013): 1746–52. http://dx.doi.org/10.1080/00958972.2013.790966.

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ENGLISH, J. S. C., R. K. WINKELMANN, J. B. LOUBACK, M. W. GREAVES und D. M. MACDONALD. „The cellular inflammatory response in nicotinate skin reactions“. British Journal of Dermatology 116, Nr. 3 (März 1987): 341–49. http://dx.doi.org/10.1111/j.1365-2133.1987.tb05848.x.

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Dowd, Pauline M., M. Whitefield und M. W. Greaves. „Hexyl-Nicotinate-Induced Vasodilation in Normal Human Skin“. Dermatology 174, Nr. 5 (1987): 239–43. http://dx.doi.org/10.1159/000249188.

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Lin, Xinping, Qiongqiong Zhang, Jiahe Chen, Xiangjian Kong, La-Sheng Long, Cheng Wang und Wenbin Lin. „Gadolinium nicotinate clusters as potential MRI contrast agents“. RSC Advances 5, Nr. 4 (2015): 2914–19. http://dx.doi.org/10.1039/c4ra07853e.

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