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Thematische Bibliographien / Novel NSAID / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Novel NSAID“

Autor: Grafiati

Veröffentlicht am 7. Juni 2025

Zuletzt aktualisiert am 2. August 2025

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1

Wallace, John L. "NSAID Gastroenteropathy: Past, Present and Future." Canadian Journal of Gastroenterology 10, no. 7 (1996): 451–59. http://dx.doi.org/10.1155/1996/850710.

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The toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) in the gastrointestinal tract continues to be a major limitation to their use in the treatment of inflammatory disorders. Better understanding of the pathogenesis of NSAID enteropathy has facilitated the development of novel NSAIDs that spare the gastrointestinal tract. In particular, identification and characterization of the inducible form of prostaglandin synthase has led to the design of novel NSAIDs that specifically target that enzyme. The pathogenesis of NSAID gastroenteropathy is reviewed, as are the strategies that have bee

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Johnson, Annie, та Michael Myers. "NSAIDs inhibit NFkβ activation to prevent inflammation (IRC4P.602)". Journal of Immunology 194, № 1_Supplement (2015): 57.19. http://dx.doi.org/10.4049/jimmunol.194.supp.57.19.

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Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) control inflammation through reductions in Prostaglandin E2 (PGE2) levels. Recent work by this laboratory identified NSAID-induced changes in inflammatory gene expression that appear to be independent of changes in PGE2; however, the molecular mechanism is unknown. Our goal is to determine whether NSAIDs affect gene expression via inhibition of NFkβ. Knowledge of NSAID gene control will provide a mechanism for screening novel drugs claiming anti-inflammatory properties. RAW 264.7 cells transfected with a plasmid under NFkβ control to expr

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&NA;. "Novel NSAID highly specific." Inpharma Weekly &NA;, no. 907 (1993): 10. http://dx.doi.org/10.2165/00128413-199309070-00020.

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Rigas, B. "Novel agents for cancer prevention based on nitric oxide." Biochemical Society Transactions 35, no. 5 (2007): 1364–68. http://dx.doi.org/10.1042/bst0351364.

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NO (nitric oxide) biology has provided the impetus for the development of anticancer agents based on their ability to release NO. NO-NSAIDs (NO-donating non-steroidal anti-inflammatory drugs), consisting of a conventional NSAID to which an NO-releasing moiety is covalently attached, are promising chemopreventive agents against cancer. Compared with their parent compounds, NO-NSAIDs are up to several hundred times more potent in inhibiting the growth of cancer cell lines and prevent colon and pancreatic cancer in animal models. Their chemopreventive effect is due to inhibition of proliferation,

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Hoggatt, Jonathan, Pratibha Singh, Amber Hoggatt, Jennifer M. Speth, and Louis M. Pelus. "Inhibition of Prostaglandin E2 (PGE2) Signaling by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or EP4 Receptor Antagonism Expands Hematopoietic Stem and Progenitor Cells (HSPC) and Enhances Their Mobilization to Peripheral Blood in Mice and Baboons." Blood 114, no. 22 (2009): 84. http://dx.doi.org/10.1182/blood.v114.22.84.84.

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Abstract Abstract 84 PGE2 is a physiological regulator of HSPC and exhibits both stimulatory and inhibitory activities. We recently reported that PGE2 increases CXCR4 expression and homing of HSPC to bone marrow (Hoggatt et al, Blood 2009). Since PGE2 is produced within the marrow microenvironment, we hypothesized that blocking PGE2 synthesis in vivo via inhibition of cyclooxygenases (COX) by NSAIDs would facilitate HSPC mobilization and serve as an adjunct to current mobilization regimens. Treatment of mice with the NSAID indomethacin b.i.d. along with G-CSF for 4 days resulted in an increase

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Tachecí, Ilja, Marcela Kopáčová, Stanislav Rejchrt, and Jan Bureš. "Non-steroidal Anti-inflammatory Drug Induced Injury to the Small Intestine." Acta Medica (Hradec Kralove, Czech Republic) 53, no. 1 (2010): 3–11. http://dx.doi.org/10.14712/18059694.2016.56.

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Non-steroidal anti-inflammatory drug (NSAIDs) induced enteropathy represents an important complication of one of the most commonly used drugs worldwide. Due to previous diagnostics difficulties the real prevalence of this disease was underestimated for a long time. The pathogenesis of NSAID-enteropathy is more multifactorial and complex than formerly assumed but has still not been fully uncovered. A combination of the local and systemic effect plays an important role in pathogenesis. Thanks to novel enteroscopy methods (wireless capsule endoscopy, double balloon enteroscopy), small bowel lesio

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Kirk, Julienne K., Jennifer M. Hamilton, and Kathy C. Phelps. "Evaluation of Novel New NSAIDs: A Review of COX-2 Inhibitors, with an Emphasis on Gastrointestinal Toxicity." Journal of Pharmacy Practice 12, no. 5 (1999): 401–11. http://dx.doi.org/10.1177/089719009901200506.

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Identification of two isoforms of cyclooxygenase, COX-1 and COX-2, has initiated a revolution in the approach to pharmacologie pain management. It has been further determined that inhibition of COX-2 reduces inflammation, and inhibition of COX-1 compromises gastrointestinal mucosal integrity. As traditional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both COX-1 and COX-2, gastrointestinal ulceration can develop in association with the use of these agents to control pain and inflammation. An ideal NSAID would, therefore, inhibit COX-2 to provide anti-inflammatory effects while leaving

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MECHCATIE, ELIZABETH. "Arthritis Advisory Panel Rejects Novel NSAID." Rheumatology News 9, no. 6 (2010): 10. https://doi.org/10.1016/s1541-9800(10)70288-x.

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PLAYFORD, Raymond J., Christopher E. MACDONALD, Denis P. CALNAN, et al. "Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability." Clinical Science 100, no. 6 (2001): 627–33. http://dx.doi.org/10.1042/cs1000627.

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Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but cause gastrointestinal injury. Present prophylactic measures are suboptimal and novel therapies are required. Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice. We therefore examined whether spray-dried, defatted colostrum could reduce the rise in gut permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and patients taking NSAIDs for clinical reasons. Healthy male volunteers (n = 7) participated in a random

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Leitch, Sharon, Jiaxu Zeng, Alesha Smith, and Tim Stokes. "Avoiding anti-inflammatories: a randomised controlled trial testing the effect of an eHealth information package on primary healthcare patient medication knowledge and behaviour in Aotearoa New Zealand." BMJ Open 14, no. 11 (2024): e081545. http://dx.doi.org/10.1136/bmjopen-2023-081545.

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BackgroundPatient medication knowledge and health literacy affect patient safety. Taking angiotensin-converting enzyme inhibitors (ACE-i) or angiotensin II receptor blockers (ARBs), with diuretics and non-steroidal anti-inflammatory medications (NSAIDs) is nephrotoxic. Patients may not know of this risk. An eHealth information package was developed to inform patients at risk of taking this combination of medication.ObjectiveTo assess the impact of the eHealth information package on patient knowledge and behaviour.DesignThis was a two-arm, parallel, randomised control trial. A knowledge quiz an

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Özdemir, Ebru, Ebru Damadoğlu, Gül Karakaya, and A. Fuat Kalyoncu. "A new classification option for NSAID hypersensitivity." Allergologia et Immunopathologia 50, no. 6 (2022): 122–27. http://dx.doi.org/10.15586/aei.v50i6.693.

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Background: The European Network for Drug Allergy (ENDA) proposed a consensus document for hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) in 2011. A subgroup of patients with NSAIDs-exacerbated respiratory disease (NERD) develop urticaria/ angioedema type reactions in response to NSAIDs. The Kalyoncu classification might be a novel option to classify patients with NSAID hypersensitivity (NH). In this study, we compare the ENDA and the Kalyoncu classifications. Methods: This study enrolled a total of 196 patients. NH reaction types were categorized as asthma, rhinit

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Roushdy, Alaa Mahmoud, Tarek M. AbdelRahman, Mahmoud Abozaid Mohamad, Makarand Suresh Gambire, and Hazem M. A. Farrag. "PDA Therapy in Preterm Infants: Early Treatment (NSAID, acetaminophen or combination) versus Watchful Waiting." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1630–32. http://dx.doi.org/10.25258/ijpqa.15.3.80.

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Drug therapy targeted for PDA closure is one of the most controversial topics, especially among preterm infants. NSAIDs have been the most widely prescribed drugs for this purpose. The argument included early drug treatment versus watchful waiting (i.e., non-pharmacological strategy) and single versus combination therapy. Previous studies concluded that early use of NSAIDs like ibuprofen resulted in a high rate of nonsurgical closure of PDAs in most treated preterm infants. Recently, the impact of early use of ibuprofen among preterm infants was studied in 2 trials. One concluded that early ib

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Hoggatt, Jonathan, Khalid S. Mohammad, Brahmananda Reddy Chitteti, et al. "Bone Marrow Niche Attenuation by Non-Steroidal Anti-Inflammatory Drugs Mobilizes Hematopoietic Stem and Progenitor Cells by Differing Mechanisms." Blood 118, no. 21 (2011): 724. http://dx.doi.org/10.1182/blood.v118.21.724.724.

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Abstract Abstract 724 Hematopoeitic stem (HSC) and progenitor cells (HPC) are localized in niches contained within the bone marrow (BM) microenvironment. To facilitate acquisition of HSC/HPC for hematopoietic transplantation, donors can be treated with granulocyte-colony stimulating factor (G-CSF) to “mobilize” HSC/HPC from the BM niche to the peripheral system. Our laboratory has recently discovered that short term administration of non-steroidal anti-inflammatory drugs (NSAIDs) also mobilizes HSC/HPC and works in synergy with G-CSF. To understand the mechanisms underlying this novel therapeu

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Ko, Kyoung A., and Dong-Kyu Lee. "Nonsteroidal Anti-Inflammatory Drug-Induced Peptic Ulcer Disease." Korean Journal of Helicobacter and Upper Gastrointestinal Research 25, no. 1 (2025): 34–41. https://doi.org/10.7704/kjhugr.2025.0004.

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for their anti-inflammatory and analgesic effects; however, their prolonged use significantly contributes to peptic ulcer disease (PUD) and its complications, such as bleeding and perforation. The pathogenesis primarily involves cyclooxygenase (COX) enzyme inhibition and direct mucosal injury, leading to impaired gastrointestinal defense mechanisms. Multiple risk factors, including advanced age, a history of ulcers, and the concurrent use of anticoagulants or corticosteroids, significantly increase the risk of ulcers and relat

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Kaduševičius, Edmundas. "Novel Applications of NSAIDs: Insight and Future Perspectives in Cardiovascular, Neurodegenerative, Diabetes and Cancer Disease Therapy." International Journal of Molecular Sciences 22, no. 12 (2021): 6637. http://dx.doi.org/10.3390/ijms22126637.

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Once it became clear that inflammation takes place in the modulation of different degenerative disease including neurodegenerative, cardiovascular, diabetes and cancer the researchers has started intensive programs evaluating potential role of non-steroidal anti-inflammatory drugs (NSAIDs) in the prevention or therapy of these diseases. This review discusses the novel mechanism of action of NSAIDs and its potential use in the pharmacotherapy of neurodegenerative, cardiovascular, diabetes and cancer diseases. Many different molecular and cellular factors which are not yet fully understood play

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Gaurav, Chaudhary Lovy Sharma. "Synthesis and Bioactivity Studies of Curcumin-NSAID Conjugates." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 3220–35. https://doi.org/10.5281/zenodo.13333231.

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In the current study, four different curcumin-NSAID conjugates are synthesized, and their biological screening for rheumatoid arthritis, anti-inflammatory, and anti-ulcer properties follows. One phytochemical with a wide range of therapeutic applications is curcumin. In the sense that it may aid in achieving the goal of incorporating specific desired properties in curcumin, such as enhanced bioavailability, reduction in side effects, and also offering good therapeutic potential in terms of determination of rheumatoid arthritis, anti-inflammatory and anti-ulcer activities of synthesized conjuga

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Gaurav, Chaudhary1 Lovy Sharma2. "Synthesis and Bioactivity Studies of Curcumin-NSAID Conjugates." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3331–46. https://doi.org/10.5281/zenodo.13337214.

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In the current study, four different curcumin-NSAID conjugates are synthesized, and their biological screening for rheumatoid arthritis, anti-inflammatory, and anti-ulcer properties follows. One phytochemical with a wide range of therapeutic applications is curcumin. In the sense that it may aid in achieving the goal of incorporating specific desired properties in curcumin, such as enhanced bioavailability, reduction in side effects, and also offering good therapeutic potential in terms of determination of rheumatoid arthritis, anti-inflammatory and anti-ulcer activities of synthesized conjuga

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Virk, Abaid ur Rehman, Iftikhar Ahmed, and Murat Cancan. "Employing Machine Learning to Analyze NSAIDs Drug Similarity via Sombor Invariants." Utilitas Mathematica 121, no. 1 (2024): 105–35. https://doi.org/10.61091/um121-08.

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This study introduces a novel approach to investigating Sombor indices and applying machine learning methods to assess the similarity of non-steroidal anti-inflammatory drugs (NSAIDs). The research aims to predict the structural similarities of nine commonly prescribed NSAIDs using a machine learning technique, specifically a linear regression model. Initially, Sombor indices are calculated for nine different NSAID drugs, providing numerical representations of their molecular structures. These indices are then used as features in a linear regression model trained to predict the similarity valu

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B, NIJA. "Prodrug Approach: NSAID Conjugates of Platinum Compounds as Anti-Cancer Agents." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 32, no. 3 (2023): 1–13. http://dx.doi.org/10.31351/vol32iss3pp1-13.

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Prodrug based synthetic approach is a very promising area of research to enhance the pharmaco–kinetic and pharmaco-dynamic properties of the drugs with the remarkable reduction of the side effects. Prodrug can be used for drugs which are having poor solubility, poor transport properties, production of chronic side effects thus this approach provides a powerful tool for novel drug conjugate with improved therapeutic value. Platinum based anti-neoplastic agents are widely used in chemotherapeutic regimen but the side effects like hepatotoxicity, ototoxicity, cardiotoxicity, nausea and vomiting,

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Bello-Vargas, Estefany, Mario Alberto Leyva-Peralta, Zeferino Gómez-Sandoval, Mario Ordóñez, and Rodrigo Said Razo-Hernández. "A Computational Method for the Binding Mode Prediction of COX-1 and COX-2 Inhibitors: Analyzing the Union of Coxibs, Oxicams, Propionic and Acetic Acids." Pharmaceuticals 16, no. 12 (2023): 1688. http://dx.doi.org/10.3390/ph16121688.

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Among the biological targets extensively investigated to improve inflammation and chronic inflammatory conditions, cyclooxygenase enzymes (COXs) occupy a prominent position. The inhibition of these enzymes, essential for mitigating inflammatory processes, is chiefly achieved through Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). In this work, we introduce a novel method—based on computational molecular docking—that could aid in the structure-based design of new compounds or the description of the anti-inflammatory activity of already-tested compounds. For this, we used eight crystal complexes

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Zhang, Xin, XiaoMei Fan, YanJun Chen, and ZhongHua Liu. "Role and Mechanism of Notch1 in Cardiomyocyte Response to Mechanical Stretch in Hypertensive Cardiac Hypertrophy and NSAID Intervention." Industry Science and Engineering 1, no. 9 (2024): 36–39. https://doi.org/10.62381/i245907.

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This study investigates the role and mechanisms of Notch1 in cardiomyocytes under mechanical stretch in the context of hypertensive cardiac hypertrophy and NSAID intervention. Using adult Sprague-Dawley rats, cardiomyocytes were isolated and cultured to establish a mechanical stretch model. Various intensities of mechanical stretch were applied to observe the expression and distribution of Notch1 and related signaling proteins (e. g., Hes1, KLF2, FABP4). Techniques such as Western blot, ELISA, immunofluorescence, electron microscopy, and RT-PCR were employed to comprehensively assess cardiomyo

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Singh, Devendra Pratap, Swapnil P. Borse, and Manish Nivsarkar. "A novel model for NSAID induced gastroenteropathy in rats." Journal of Pharmacological and Toxicological Methods 78 (March 2016): 66–75. http://dx.doi.org/10.1016/j.vascn.2015.11.008.

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Jancin, Bruce. "Novel PPI-NSAID Pill May Prevent GI Mucosal Injury." Family Practice News 36, no. 3 (2006): 37. http://dx.doi.org/10.1016/s0300-7073(06)72632-9.

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Ramos-Inza, Sandra, Cristina Morán-Serradilla, Leire Gaviria-Soteras, et al. "Formulation Studies with Cyclodextrins for Novel Selenium NSAID Derivatives." International Journal of Molecular Sciences 25, no. 3 (2024): 1532. http://dx.doi.org/10.3390/ijms25031532.

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Commercial cyclodextrins (CDs) are commonly used to form inclusion complexes (ICs) with different molecules in order to enhance their water solubility, stability, and bioavailability. Nowadays, there is strong, convincing evidence of the anticancer effect of selenium (Se)-containing compounds. However, pharmaceutical limitations, such as an unpleasant taste or poor aqueous solubility, impede their further evaluation and clinical use. In this work, we study the enhancement of solubility with CD complexes for a set of different nonsteroidal anti-inflammatory drug (NSAID) derivatives with Se as s

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Yeh, Bo-Yan, Geng-Hao Liu, Tzung-Yan Lee, Alice May-Kuen Wong, Hen-Hong Chang, and Yu-Sheng Chen. "Efficacy of Electronic Acupuncture Shoes for Chronic Low Back Pain: Double-Blinded Randomized Controlled Trial." Journal of Medical Internet Research 22, no. 10 (2020): e22324. http://dx.doi.org/10.2196/22324.

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Background Chronic low back pain is a common problem and is associated with high costs, including those related to health care and indirect costs due to absence at work or reduced productivity. Previous studies have demonstrated that acupuncture or electroacupuncture can relieve low back pain. Electronic acupuncture shoes (EAS) are a novel device designed in this study. This device combines the properties of acupuncture and transcutaneous electrical nerve stimulation for clinical use. Objective The aim of this study was to evaluate the efficacy of EAS in patients with chronic low back pain. Me

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Raza, Kaisar, Manish Kumar, Pramod Kumar, et al. "Topical Delivery of Aceclofenac: Challenges and Promises of Novel Drug Delivery Systems." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/406731.

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Osteoarthritis (OA), a common musculoskeletal disorder, is projected to affect about 60 million people of total world population by 2020. The associated pain and disability impair the quality of life and also pose economic burden to the patient. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed in OA, while diclofenac is the most prescribed one. Oral NSAIDs are not very patient friendly, as they cause various gastrointestinal adverse effects like bleeding, ulceration, and perforation. To enhance the tolerability of diclofenac and decrease the common side effects, aceclofenac

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Austin, Publishing Group. "Synthesis and Biological Evaluation of Curcumin-NSAIDs Conjugates." Austin Journal of Analytical and Pharmaceutical Chemistry 10, no. 1 (2023): 1153. https://doi.org/10.26420/austinjanalpharmchem.2023.1153.

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Abstract The present research work involves the synthesis of a total of four Curcumin-NSAIDs conjugates and their subsequent biological screening for Rheumatoid Arthritis, Anti-inflammatory, and Anti-ulcer activities. Curcumin is a phytochemical having versatile therapeutic potential. The idea of conjugating curcumin with various NSAIDs is somewhat novel in the sense that it helps in obtaining the target of incorporating certain desired properties in the curcumin like enhanced bioavailability, reduction in the side effects and also giving good therapeutic potential in terms of determination of

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Kashfi, Khosrow. "Development of NOSH-NSAIDs: a new class of anti-inflammatory pharmaceuticals for the treatment of cancer." Biochemist 39, no. 4 (2017): 24–29. http://dx.doi.org/10.1042/bio03904024.

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Non-steroidal anti-inflammatory drugs (NSAIDs) have anti-cancer (chemopreventive) properties; however, side effects preclude their long-term use. NOSH-NSAIDs, designed as safer alternatives, are novel hybrid chimaeras that release nitric oxide (NO) and hydrogen sulfide (H2S). NOSH-NSAIDs are gastrointestinally safe yet retain all the pharmacological properties of their native NSAID. NOSHNSAIDs are orders of magnitude more potent than their conventional counterparts in inhibiting the growth of various human cancer cell lines of different tissue origins, adenomatous, epithelial and lymphocytic.

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Anjitha, M.1* K. Selvaraju2 N. L. Gowrishankar3 Athulya Prasad4 Arun Giri Raj V.5 Shabna S.6. "Transferosomes, Revolutionizing NSAIDS Delivery For Improved Therapeutic Efficacy: A Systematic Review Of Formulation Strategies And Evaluations." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3553–60. https://doi.org/10.5281/zenodo.13351322.

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Non-steroidal anti-inflammatory medicines, or NSAIDs, are becoming becoming increasingly common due to their widespread acceptance as necessary medications for the efficient treatment of pain and inflammation. They possess antipyretic, analgesic, and anti-inflammatory characteristics. On the other hand, taking NSAIDs orally can result in a number of adverse effects  in gastrointestinal tract, pulmonary, cardiovascular systems. As a result, transdermal NSAIDs application were suggested over the oral NSAID administration for the treatment of pain and inflammation. Medication applied directl

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CHAN, FRANCIS K. L., BYRON CRYER, JAY L. GOLDSTEIN, et al. "A Novel Composite Endpoint to Evaluate the Gastrointestinal (GI) Effects of Nonsteroidal Antiinflammatory Drugs Through the Entire GI Tract." Journal of Rheumatology 37, no. 1 (2009): 167–74. http://dx.doi.org/10.3899/jrheum.090168.

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Objective.Nonsteroidal antiinflammatory drugs (NSAID) not only cause damage to the upper gastrointestinal (GI) tract but also affect the lower GI tract. To date, there is no endpoint that evaluates serious GI events in the entire GI tract. The objective of this report is to introduce a novel composite endpoint that measures damage to the entire GI tract — clinically significant upper and lower GI events (CSULGIE) — in patients with NSAID-induced GI damage.Methods.We reviewed the data from largescale, multicenter, randomized, clinical trials on lower GI toxicity associated with NSAID use. The r

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Pardhe, Vaishali, Ashish Jain, and Akhlesh Kumar Singhai. "A Novel Approach on Nanosphere Based Colon Targeted Drug Delivery System." Journal of Biomedical and Pharmaceutical Research 13, no. 2 (2024): 1–8. http://dx.doi.org/10.32553/jbpr.v13i2.1073.

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Oral route is the most feasible and desired one, CDDS may also employ alternative methods. When administering medications directly to the colon, rectal administration is the fastest method. Rectal administration makes it challenging to reach the proximal portion of the colon. Rectal administration may potentially cause patients discomfort and result in poor compliance. Particles with a diameter between 10 and 200 nm are known as nanospheres. Nanospheres can be crystalline or amorphous in form, and they can shield a medicine from enzymatic and chemical deterioration. When treating colonic illne

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Sinha, Mau, Lovely Gautam, Prakash Kumar Shukla, Punit Kaur, Sujata Sharma, and Tej P. Singh. "Current Perspectives in NSAID-Induced Gastropathy." Mediators of Inflammation 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/258209.

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. Though several approaches for limiting these side effects have been adopted, like the use of COX-2 specific drugs, comedication of acid suppressants like proton pump inhibitors and prostaglandin analogs, these alternatives have limitations in terms of efficacy and side effects. In this paper, the mechanism of ac

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Baker, L. M., B. Hauss-Wegrzyniak, and G. L. Wenk. "The effect of a novel NO-NSAID on chronic neuroinflammation." Journal of Neuroimmunology 90, no. 1 (1998): 79. http://dx.doi.org/10.1016/s0165-5728(98)91653-8.

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Kunte, Dhananjay, Ramesh K. Wali, Mart DeLaCruz, et al. "MicroRNAs as Novel Targets for NSAID Chemoprevention of Colon Carcinogenesis." Gastroenterology 140, no. 5 (2011): S—41. http://dx.doi.org/10.1016/s0016-5085(11)60163-7.

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Acebedo-Martínez, Francisco Javier, Alicia Domínguez-Martín, Carolina Alarcón-Payer, et al. "Metformin-NSAIDs Molecular Salts: A Path towards Enhanced Oral Bioavailability and Stability." Pharmaceutics 15, no. 2 (2023): 449. http://dx.doi.org/10.3390/pharmaceutics15020449.

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According to the World Health Organization, more than 422 million people worldwide have diabetes. The most common oral treatment for type 2 diabetes is the drug metformin (MTF), which is usually formulated as a hydrochloride to achieve higher water solubility. However, this drug is also highly hygroscopic, thus showing stability problems. Another kind of worldwide prescribed drug is the non-steroidal anti-inflammatory drug (NSAID). These latter, on the contrary, show a low solubility profile; therefore, they must be administered at high doses, which increases the probability of secondary effec

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Mishchenko, Mariia, Sergiy Shtrygol’, Andrii Lozynskyi, et al. "Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues." Scientia Pharmaceutica 89, no. 2 (2021): 22. http://dx.doi.org/10.3390/scipharm89020022.

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Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive conditions, and non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the contemporary search and design of novel anticonvulsants. In the present paper, evaluation of the anticonvulsant activity of the potential NSAID dual COX-2/5-LOX inhibitor darbufelone methanesulfonate using an scPTZ model in mice in dose 100 mg/kg is reported. Darbufelone possesses anticonvulsant properties in the scPTZ model and presents interest for in-depth studies as a possible anticonvulsant multi-target agent with

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Kennedy-Lydon, Teresa, Carol Crawford, Scott S. Wildman, and Claire M. Peppiatt-Wildman. "Nonsteroidal anti-inflammatory drugs alter vasa recta diameter via pericytes." American Journal of Physiology-Renal Physiology 309, no. 7 (2015): F648—F657. http://dx.doi.org/10.1152/ajprenal.00199.2015.

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We have previously shown that vasa recta pericytes are known to dilate vasa recta capillaries in the presence of PGE2 and contract vasa recta capillaries when endogenous production of PGE2 is inhibited by the nonselective nonsteroidal anti-inflammatory drug (NSAID) indomethacin. In the present study, we used a live rat kidney slice model to build on these initial observations and provide novel data that demonstrate that nonselective, cyclooxygenase-1-selective, and cyclooxygenase -2-selective NSAIDs act via medullary pericytes to elicit a reduction of vasa recta diameter. Real-time images of i

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Perković, Ivana, Zrinka Rajić Džolić, and Branka Zorc. "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties." Acta Pharmaceutica 63, no. 3 (2013): 409–18. http://dx.doi.org/10.2478/acph-2013-0023.

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Abstract A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each t

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Pawełczyk, Anna, Rafał Nowak, Monika Gazecka, Anna Jelińska, Lucjusz Zaprutko, and Paweł Zmora. "Novel Molecular Consortia of Cannabidiol with Nonsteroidal Anti-Inflammatory Drugs Inhibit Emerging Coronaviruses’ Entry." Pathogens 12, no. 7 (2023): 951. http://dx.doi.org/10.3390/pathogens12070951.

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The COVID-19 pandemic provoked a global health crisis and highlighted the need for new therapeutic strategies. In this study, we explore the potential of the molecular consortia of cannabidiol (CBD) and non-steroidal anti-inflammatory drugs (NSAIDs) as novel antiviral dual-target agents against SARS-CoV-2/COVID-19. CBD is a natural compound with a wide range of therapeutic activities, including antiviral and anti-inflammatory properties, while NSAIDs are commonly used to mitigate the symptoms of viral infections. Chemical modifications of CBD with NSAIDs were performed to obtain dual-target ag

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Ramos-Inza, Sandra, Cesar Aliaga, Asif Raza, et al. "Abstract 5451: New organoselenium compounds with cytotoxic activity in vitro and in vivo towards colon cancer." Cancer Research 82, no. 12_Supplement (2022): 5451. http://dx.doi.org/10.1158/1538-7445.am2022-5451.

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Abstract Colon cancer is currently the third most common diagnosed cancer and the second leading cause of cancer death worldwide. The inclusion of a selenium atom (Se) in organic molecules has been shown to be a valid approximation in the design of novel chemotherapeutic agents with antitumoral activity. On the other hand, non-steroidal anti-inflammatory drugs (NSAIDs) have gained interest in recent years in terms of their chemopreventive and chemotherapeutic use for cancer treatment whether they are evaluated alone, as a combination therapy, or in the form of structurally modified analogs. Co

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sailaja, Abbaraju Krishna. "Aspirin Loaded Niosomes A Novel Drug Delivery System by Ether Injection Method." Nanomedicine & Nanotechnology Open Access 8, no. 3 (2023): 1–5. http://dx.doi.org/10.23880/nnoa-16000237.

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Acetylsalicylic acid (ASA), generally known as aspirin, is a nonsteroidal anti-inflammatory medication (NSAID) used to treat inflammation, fever, and pain. It also has an anti-platelet action, which lowers blood clotting by reducing platelet levels and preventing heart attacks. Aspirin's common gastrointestinal side effects are stomach ulcers and bleeding. Niosomes are vesicular drug delivery system that can enhance therapeutic efficacy and minimise side effects by encapsulating aspirin into vesicles. In this study, niosomes were prepared by the ether injection method, and a total of six formu

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Cacciatore, Ivana, Lisa Marinelli, Erika Fornasari, et al. "Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer’s Disease." International Journal of Molecular Sciences 17, no. 7 (2016): 1035. http://dx.doi.org/10.3390/ijms17071035.

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Ivanov, Iliyan, Stanimir Manolov, Dimitar Bojilov, et al. "Synthesis of Novel Benzothiazole–Profen Hybrid Amides as Potential NSAID Candidates." Molecules 30, no. 1 (2024): 107. https://doi.org/10.3390/molecules30010107.

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Herein, we report the synthesis of a series of new compounds by combining 2-aminobenzothiazole with various profens. The compounds were characterized using techniques such as 1H- and 13C-NMR, FT-IR spectrometry, and high-resolution mass spectrometry (HRMS), with detailed HRMS analysis conducted for each molecule. Their biological activities were tested in vitro, revealing significant anti-inflammatory and antioxidant effects, comparable to those of standard reference compounds. Lipophilicity was experimentally determined through partition coefficient (RM) measurements. To understand their bind

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Mo¨ller, Norbert L., Klaus E. Dietzel, H. Thomas Schneider, and Kay Brune. "Novel 5-aminosalicylic acid NSAID conjugates: synthesis; pharmacological and toxicological properties." European Journal of Medicinal Chemistry 24, no. 5 (1989): 463–69. http://dx.doi.org/10.1016/0223-5234(89)90048-2.

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Ramos-Inza, Sandra, Cesar Aliaga, Ignacio Encío, et al. "First Generation of Antioxidant Precursors for Bioisosteric Se-NSAIDs: Design, Synthesis, and In Vitro and In Vivo Anticancer Evaluation." Antioxidants 12, no. 9 (2023): 1666. http://dx.doi.org/10.3390/antiox12091666.

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The introduction of selenium (Se) into organic scaffolds has been demonstrated to be a promising framework in the field of medicinal chemistry. A novel design of nonsteroidal anti-inflammatory drug (NSAID) derivatives based on a bioisosteric replacement via the incorporation of Se as diacyl diselenide is reported. The antioxidant activity was assessed using the DPPH radical scavenging assay. The new Se-NSAID derivatives bearing this unique combination showed antioxidant activity in a time- and dose-dependent manner, and also displayed different antiproliferative profiles in a panel of eight ca

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Ilkiv, I. I., R. B. Lesyk, and O. Ya Sklyarov. "The influence of novel 4-thiazolidinone derivaties in cytoprotective mechanisms of small intestine under nsaid-induced damage." Ukrainian Biochemical Journal 88, Special Issue (2016): 99–104. http://dx.doi.org/10.15407/ubj88.si01.099.

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Chiou, Shiun-Kwei. "W1094 NSAIDs Increase Gadd45a Expression in Colon Cancer Cells: A Novel Mechanism of NSAID-Induced Colon Cancer Cell Apoptosis." Gastroenterology 134, no. 4 (2008): A—632. http://dx.doi.org/10.1016/s0016-5085(08)62950-9.

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Bibik, E. Yu, A. V. Myazina, K. A. Frolov, V. V. Dotsenko, and S. G. Krivokolysko. "Impact of new 1,4‑dihydrothiopyridine derivatives with analgesic activity on gastric mucosa." Glavvrač (Chief Medical Officer), no. 9 (August 31, 2022): 16–18. http://dx.doi.org/10.33920/med-03-2209-04.

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In clinical practice, the occurrence of such a side effect as gastrotoxicity can occur in patients taking NSAIDs with any route of administration. In this case, damage not only to the upper parts of the digestive tract is noted, but also to the intestine as a whole, since NSAID-induced enteropathy is manifested by the intestinal permeability disorder with protein exudation and diapedesis of erythrocytes, as well as by the development of erosions, ulcers, and life-threatening complications: bleeding, perforation, intestinal obstruction, and the appearance of circular folds [1]. The purpose of t

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Krishna Kar and Bhavisha Patel. "“A Comprehensive Review on Selective Dual Inhibitor NSAID - Polmacoxib”." Journal of Advanced Zoology 45, no. 1 (2024): 885–89. http://dx.doi.org/10.17762/jaz.v45i1.3431.

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The review article provides extensive overview on the promising pharmaceutical compound, polmacoxib also known as CG100649, explaining its pharmacological properties, chemical and physical properties, clinical studies and analytical methods. Polmacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID) that has shown significant interest in recent years for its potential therapeutic benefits in Osteoarthritis treatment and distinct analytical characteristics. The chemical and pharmacological section in this review depicts the choice of solvents to be used through its solubility profile and

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Christensen, Kyle, Stephen Daniels, Donald Bandy, et al. "A Double-Blind Placebo-Controlled Comparison of a Novel Formulation of Intravenous Diclofenac and Ketorolac for Postoperative Third Molar Extraction Pain." Anesthesia Progress 58, no. 2 (2011): 73–81. http://dx.doi.org/10.2344/0003-3006-58.2.73.

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Abstract Dyloject is a novel formulation of diclofenac intended for intravenous (IV) administration. This formulation employs the solubilizing agent hydroxypropyl-β-cyclodextrin to permit bolus IV administration. The efficacy and safety of 5 dose levels of IV diclofenac were compared with IV ketorolac and placebo following third molar extraction. This was a single-dose, randomized, double-blind, placebo- and comparator-controlled, parallel-group study. A total of 353 subjects with moderate to severe pain received placebo; ketorolac 30 mg; or IV diclofenac 3.75, 9.4, 18.75, 37.5, or 75 mg (N =

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