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Thematische Bibliographien / Pathogens / Dissertationen

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Dissertationen zum Thema „Pathogens“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 25. Juli 2025

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1

Hovhannisyan, Hrant 1992. "Comparative transcriptomics of host-pathogen interactions and hybridization in Candida pathogens." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/670316.

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Candida pathogenic yeasts represent a global healthcare problem. They comprise phylogenetically diverse species, including newly emerged pathogens. How human-Candida interactions vary across species, and what processes underlie the emergence of novel pathogens are poorly understood. Current thesis addresses these issues using comparative transcriptomics and bioinformatics. We established the global patterns of host-pathogen interactions between human host and the main Candida species, providing novel mechanistic insights into their interplay. We also explored lncRNAs of these pathogens, assess

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2

Kärkkäinen, Riikka M. "Production of DNA aptamers with specificity for bacterial food pathogens." Thesis, University of Chester, 2012. http://hdl.handle.net/10034/620695.

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Aptamers are biomolecular ligands composed of nucleic acids. They can be selected to bind specifically to a range of target molecules and subsequently exploited in a fashion analogous to more traditional biomolecules such as antibodies. In this study a method for selecting new aptamers which specifically bind whole live bacterial cells is described. A non-pathogenic strain of Escherichia coli K12 was used to develop the method. A DNA library containing 100 bases long random nucleotide sequences was produced and the aptamer selection process was repeated nine times. An enzyme-linked technique w

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3

Gibson, Josie. "In vivo imaging and analysis of host-pathogen interactions of intracellular pathogens." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19047/.

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Cellular and extracellular host-pathogen interactions are important in the progression of infection. Extracellular survival and growth can be significant for pathogen dissemination. Equally, intracellular pathways, such as autophagy, can be employed in host cell defence. Autophagy is a cellular self-degradation process that recycles cellular components through lysosomal degradation. Primarily for regulating starvation and housekeeping pathways, autophagy is also important for degradation of invading intracellular pathogens. Selective autophagy receptors can also target pathogens for autophagic

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4

Jones, Steven Michael. "Nosocomial pathogens within biofilms." Thesis, University of Exeter, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370017.

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5

Ahmad, Sarah. "Identification of pathogen-specific protein-encoding genes from microbial pathogens based on bioinformatic analysis." Thesis, University of Exeter, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425246.

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6

Sousa, Oliveira Márcia Patrícia de. "Microbial safety of lettuce: foodborne pathogens incidence, their pathogenic potential and biopreservative stratagies." Doctoral thesis, Universitat de Lleida, 2015. http://hdl.handle.net/10803/307379.

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La investigació descrita en aquesta tesi es centra en la determinació de la influència de les pràctiques de maneig del cultiu, processament i les condicions d'emmagatzematge en la qualitat microbiològica de l'enciam mínimament processat i en l'estudi de les estratègies de mitigació per millorar la seva seguretat. S'ha estudiat l'efecte del sistema de producció, orgànica o convencional, de la qualitat microbiològica d'enciam fresc. Es va avaluar la transferència i la persistència de L. innocua i E. coli O157:H7 en els fulls d'enciam i en el sòl durant la tardor i la primavera utilitzant diferen

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Mixão, Verónica de Pinho 1991. "Hybridization in Candida yeast pathogens." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/670103.

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Candida species are among the most important fungal pathogens. Although Candida albicans is the most common cause of Candida infections, many other Candida species have emerged as pathogens. How pathogenicity is evolutionary acquired is unknown, but previous studies point to a role of hybridization in its development. This thesis studied the genomic features of Candida pathogens, with a special focus on hybrids and their evolution. Specifically, it asked the questions of how spread are hybrids among Candida species, and what are the processes that drive the evolution of their genomes. To this

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8

Dawkins, Glenys Heather Mary. "Plant pathogens and ecological succession." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/8317.

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9

Krüger, Carina. "Passive immunization against oral pathogens /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-960-9/.

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10

Encheva, Vesela. "Proteome analysis of bacterial pathogens." Thesis, University of East London, 2005. http://roar.uel.ac.uk/1301/.

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The explosive progress over the past decade in the fields of genomics, bioinformatics and mass spectrometry has resulted in an increased capability to investigate and compare the global protein expression of cells, tissues and organisms. The main focus of this study was on characterising the protein expression profiles of different serovars of Salmonella enterica and different serotypeso f Streptococcusp neumoniae in an attempt to identify protein factors associatedw ith host specificity and virulence. A novel approach for typing of bacterial isolates using SELDI TOF MS was developed. A thorou

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11

McGinley, Susan. "Emerging Pathogens: Detecting Waterborne Microsporidia." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2000. http://hdl.handle.net/10150/622275.

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12

SHAHZAD, GUL I. RAYNA. "BIOCONTROL STRATEGIES AGAINST PLANT PATHOGENS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/850186.

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It is a known fact that the whole agriculture system is suffering from the diseases caused by plant pathogens, affecting negatively the crop yield production, food security, biodiversity, agricultural ecosystem and hence agricultural economy. In many countries, the containment strategies of plant pathogens are still depending on chemical pesticides that cause adverse effects in the long term. According to the implementations reinforced by European council 2009/128/EC, biocontrol strategies are considered as the most profound and integrated approach for sustainable disease management. Defining

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13

Cotter, Sheena C. "Trade-offs in insect disease resistance." Thesis, University of Stirling, 2002. http://hdl.handle.net/1893/26688.

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The ability to mount an efficient immune response should be an important life-history trait as parasitism can impact upon an individual's fecundity and survival prospects, and hence its fitness. However, immune function is likely to be costly as resources must be divided between many important traits. Whilst many studies have examined host resistance to particular parasite types, fewer have considered general immune responses. Studies that have considered general immune responses tend to do so in vertebrate models. However, the complexity of the vertebrate immune system makes the examination o

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14

Almiman, Bandar F. "Molecular genetic and genomic characterization of an emerging mycotoxigenic pathogen Fusarium proliferatum." Thesis, University of Bedfordshire, 2018. http://hdl.handle.net/10547/622835.

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This aim of this research was to elucidate the genotypic diversity of the mycotoxigenic species Fusarium proliferatum associated with diverse hosts and distributed in wide geographic locations to gain new insights into the biology of this emerging pathogen. This study developed a novel molecular genetic marker FG1056. Multilocus typing of F. proliferatum isolates (52) using F. verticillioides (2) and F. oxysporum (3) as references was carried out with FG1056 and a set of known genetic markers (ITS, TEF1, CAL and FUM1). This distinguished up to 10 genetic groups, 2 clusters and 23 haplotypes am

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15

Fuchs, Thilo Martin. "Functional genomics of food-borne pathogens." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980821266.

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16

Hultberg, Anna. "Lactobacilli expressing antibody fragments against pathogens /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-862-2/.

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17

Melander, Margareta. "Transgenic resistance to pathogens and pests /." Alnarp : Dept. of Crop Science, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/a496.pdf.

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18

Meier, Christoph. "Structural genomics of two human pathogens." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437351.

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19

Behrends, Volker. "Metabolic profiling of cystic fibrosis pathogens." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511871.

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20

Smith, Leanne May. "Investigating phagosome dynamics of microbial pathogens." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/4937/.

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Many microbial pathogens are able to evade killing by phagocytes of the innate immune system. This thesis focuses on two pathogens: the fungal pathogen \(Cryptococcus\) \(neoformans\) and the bacterial pathogen \(Streptococcus\) \(agalactiae\). \(C\). \(neoformans\) causes severe cryptococcal meningitis in mostly immunocompromised hosts, such as those with HIV infection. In contrast, \(S\). \(agalactiae\) is the leading cause of neonatal sepsis and meningitis. The interaction between macrophages and these pathogens is likely to be critical in determining dissemination and outcome of disease in

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Al-Groosh, D. H. A. "Opportunistic pathogens associated with orthodontic retainers." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1419096/.

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Orthodontic retainers may be considered as removable implants and confer the same problems as other implants with regard to colonisation by microorganisms. Thus, biofilms forming on their surface may compromise the oral health of patients and jeopardise the efficiency of the therapy. The first part of the project involved a clinical study, a cross-sectional observational cohort, to assess the effect of orthodontic treatment on the oral microbiota and the carriage state of opportunistic pathogens during the course of treatment. High proportions of health-associated species were detected in the

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Watkins, Eleanor Rose. "The population structure of bacterial pathogens." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:8ab53aa1-c55f-40bc-ab4f-ec2766b37252.

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Populations of many bacterial pathogens are structured into discrete strains despite frequent genetic exchange. Although insights from several studies suggest that different selection pressures operate in different areas of the genome, few theoretical and conceptual frameworks of bacterial population structure examine the effects of distinct competitive processes acting on different loci in the genome, and fewer still have considered the metabolic genes despite their increasingly-recognised importance in virulence. Buckee et al. (2008) investigated the combined effects of ecological competitio

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Goller, Katja Verena. "Pathogens in free-ranging African carnivores." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16393.

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Die ökologische Rolle der meisten Wildtier-Pathogene in Bezug zur langfristigen Populationsdynamik ihrer Wirte ist nur ansatzweise erforscht und wird deshalb nur unzureichend verstanden. Stattdessen ist die Erforschung von Infektionen mit Pathogenen oft beschränkt auf einzelne Fallstudien oder auf Perioden mit deutlich erhöhten Mortalitätsraten innerhalb der Wirtspopulation. Pathogene mit geringer Virulenz können jedoch durch synergistisches Auftreten verheerende Auswirkungen auf die Fitness ihrer Wirte haben oder sich auf wichtige individuelle lebensgeschichtliche Merkmale, wie zum Beispiel L

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24

Abnave, Prasad. "Exploring mammalian immunity against intracellular bacteria through planarian flatworms." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5049.

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Les interactions hôte-pathogène sont un jeu vaste et complexe entre agent pathogène et hôtepour la victoire de la bataille de la pathogenèse. Plusieurs organismes modèles sont étudiéspour illustrer les mécanismes impliqués dans ces interactions. Dans ma thèse, j'ai utilisé lesplanaires comme un organisme modèle pour explorer les interactions hôte-pathogène. Comme les différents organismes modèles peuvent mettre enévidence les différentes caractéristiques de l'immunité, j'ai décidé de tirer avantage del'absence de connaissances sur l'immunité des planaires en explorant l'inexplorée. Dans monpro

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Younis, Hussein Mariam. "Sources of human pathogens in urban waters." Thesis, Halmstad University, School of Business and Engineering (SET), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-2354.

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<p>The presence of human pathogens in water indicates the sanitary risk associated with different types of water utilization. This study surveyed the sources of human pathogens in urban waters. In order to evaluate the microbiological water quality of urban water, the enumeration of various indicator bacteria (total coliform, fecal coliform, E.coli and enterococci) is usually used.</p><p>The abundance of indicator bacteria in urban water indicates the level of fecal contamination and the presence of other human pathogens such as protozoan pathogens (Giardia lamblia & Cryptosporidium parvum).</

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Hao, Xingkai. "Detection of Foodborne Pathogens Using Microfluidic Channels." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32171.

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Rapid detection of foodborne pathogen is one of the most urgent problems in the world, because foodborne pathogen could cause serious illness, such as nausea, vomiting and diarrhea. We have developed a sensitive microfluidic system based on dendrimers and aptamers for rapid detection of Escherichia coli O157:H7 at very low cells concentration. Dendrimers, with high level of functional groups and homogeneous spherical shape, are prefect nanoscale polymers used as a template material by increasing sensitivity and specificity of analytes detection in microfluidics. In this work, we develop a sens

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27

Chen, Desheng, and chen desheng@deakin edu au. "Development of monoclonal antibodies against Vibrio pathogens." Deakin University. Department of Biological Science, 1991. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20080626.140825.

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Monoclonal antibodies were developed against pathogenic vibrios for use in rapid identification in disease situations of humans, fish and shellfish. Of the 12 fusions performed using V. alginolyticus, V. anguillarum, V. carchariae, V. cholerae, V. damsela, V. furnissii, V. harveyi, V. ordalii, V. parahaemolyticus and V. vulnificus, a total of 102 hybridomas were obtained. Based on cross-reactivity of a wide range of V

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Williams, Katrina Anne. "Modeling post-harvest pathogens in apple fruit." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43746.

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Post-harvest disease of apple fruit causes significant loss of fruit during and after storage with a considerable economic impact. Studying the factors that contribute to post-harvest disease and developing predictive models may help growers and packing house workers to make more informed decisions on disease forecasting and duration of storage for apples. Data for three major post-harvest pathogens, Penicillium expansum, Botrytis cinerea and Mucor piriformis, which were monitored and quantified in four orchards over three years during the growing season and then in storage, were available. Co

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O'Brien, John Kieran. "Interactions between bovine leucocytes and respiratory pathogens." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254519.

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Scholes, Julie Diane. "The effects of biotrophic pathogens of photosynthesis." Thesis, Bangor University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237087.

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31

Tallentire, Eva Elizabeth. "Novel methods of controlling targeted potato pathogens." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519481.

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32

Woo, Chiu-yat Patrick, and 胡釗逸. "Defining novel clinical syndromes and emerging pathogens." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B27497343.

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33

Lin, Xiaonan. "Chemical and Cellular Defenses against Foreign Pathogens." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10354.

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Bacterial and viral infections affect billions of people each year. While bacterial infections are treated by the use of antibiotics, viral infections are eradicated by the immune system. This thesis comprises two parts. Part I presents the reconstitution of enzymes required for the synthesis of the minimal pharmacophore of moenomycin A (MmA), a molecule with antibacterial activity. Part II details single-particle electron microscopy studies of MDA5 alone and in complex with double-stranded RNA (dsRNA). MmA is a natural product antibiotic from Streptomyces ghanaensis that possesses remarkable

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Sutherland, Margery Louise. "Recognition of host plants by vascular pathogens." Thesis, University of Reading, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303155.

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35

Knell, Robert James. "The population ecology of two insect pathogens." Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284218.

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36

Frey, Andrew. "Investigation of the sialidases of periodontal pathogens." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/16411/.

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Periodontitis results in destruction of tooth supporting structures, eventually leading to tooth loss, and it affects ~10% of the world's population. Key to its onset and progression is a complex relationship between the periodontal bacteria and the host inflammatory response. The bacteria most associated with severe periodontitis are the so-called periodontal pathogens of the red complex- Tannerella forsythia, Treponema denticola, and Porphyromonas gingivalis. These organisms all express sialidases, which cleave sialic acid from host glycoproteins, and this is believed to contribute to diseas

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Patrick, Sheila. "Opportunistic pathogens of the normal human microbiota." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/25062.

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To the colonising bacterium, the human body represents a number of ecological niches, some of which it could be argued are as hostile to the coloniser as even the most extreme of ex vivo environments; by the activities of the immune system, these living host niches are actively dedicated to the prevention of their colonisation. Paradoxically, the normal human microbiota of each human extends in estimated total number to approximately 1014 per human. This thesis is a compilation of published work that focuses on two anaerobic bacteria of the normal human microbiota: Bacteroides fragilis predomi

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Vágány, Viktória. "Characterisation of fusarium pathogens in the UK." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/56393/.

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The primary aim of this project was to identify and characterise Fusarium species associated with the basal rot of Allium species and internal fruit rot of sweet peppers in the UK. The secondary objective was to develop quick molecular markers to identify Fusarium oxysporum f. sp. cepae (FOC) causing onion basal rot. Isolates representing diverse Fusarium species taken from onions, garlic, shallot and leeks obtained from different production and processing sites in the UK were collected. F. proliferatum was found for the first time to be a causal agent of onion basal rot in the UK, but F. oxys

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Poole, Sophie. "Aetiological links between oral pathogens and dementia." Thesis, University of Central Lancashire, 2014. http://clok.uclan.ac.uk/11156/.

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Introduction: Several observational studies support an association between periodontal disease and Alzheimer’s disease (AD). Poorly managed oral hygiene together with the immunosuppressed status of demented patients appears central to this hypothesis as together they contribute not only to an increased incidence of oral infections but also to recurrent bacteraemia that can seed oral bacteria into systemic circulation. The aim of this study was to establish a link between periodontal disease and AD with a view to identifying the red complex periodontal disease bacteria (Treponema denticola, Tan

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Dearlove, Bethany Lorna. "Genome evolution and epidemiology of human pathogens." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:af385d35-ca1a-4f4c-ae1a-0ad954cab928.

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Understanding the transmission dynamics of infectious diseases is important to well-informed public health policy, responsive infection control and individual patient management. The on-going revolution in whole-genome sequencing provides unprecedented resolution for detecting evidence of recent transmission and characterising population-level transmission dynamics. In this thesis, I develop and apply evolutionary approaches to investigating transmission, focusing on three globally important pathogens. Hepatitis C virus (HCV) is a major cause of liver disease affecting 150 million people and k

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Smith, Sara Jean. "Attachment and Biofilm Formation of Foodborne Pathogens." Thesis, North Dakota State University, 2017. https://hdl.handle.net/10365/28387.

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Outbreaks of Listeria monocytogenes, Salmonella, and Escherichia coli are increasingly attributed to fresh produce. Current control measures have been assessed for decades, with no alternatives adopted. Sources were identified, reducing flhD transcription and biofilm amounts nearly 2-fold. ?-phenylethylamine (PEA), reduced growth and biofilm 96% and 70%, respectively. Curli production was assessed and found to be microorganism-, strain-, and/or serotype-dependent. Reporter fusions were constructed, evaluating expression of Listeria cellulose protein (Lcp). Plcp was not impacted by conditions u

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Mastropaolo, Matthew David. "Studies of Three Human Intestinal Opportunistic Pathogens." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28529.

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Opportunistic bacterial pathogens are present in the intestines of all mammals. These bacteria are symbionts to a certain extent, but under certain conditions these organisms can be deadly. Intestinal opportunistic pathogens encompass many genera and include organisms such as those in the Bacteroides fragilis group (i.e. B. fragilis and B. thetaiotaomicron), Escherichia coli, and Clostridium perfringens, resulting in an array of diseases and serious health risks. Typically these diseases affect individuals in poor or weakened health (elderly, immuno-compromised, neonates, etc.) but can affe

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Szwetkowski, Kyle John. "Methylobacterium spp.: Emerging Opportunistic Premise Plumbing Pathogens." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/77659.

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Opportunistic premise plumbing pathogens (OPPPs) are responsible for many infections linked to drinking water. The annual cost of disease caused by these waterborne pathogens is $850 million. Key characteristics of these opportunistic waterborne pathogens include: disinfectant- resistant, biofilm formation, thermal-tolerance, desiccation-resistant, growth in amoebae and growth in low oxygen conditions. Methylobacterium spp. have been recognized as an emerging OPPP, so the purpose of this study was to investigate these waterborne bacteria in more detail to determine whether they have all charac

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Gallegos, Karen M. "Characterization of Pathogens for Potential Diagnostic Tests." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367942509.

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Sampson, Mark M. "Role of chitinases in bacterial insect pathogens." Thesis, University of Aberdeen, 1997. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU117909.

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Chitinases have been proposed to play a key role in the virulence of microbial insect pathogens. The chitinolytic properties of the biopesticides Bacillus thuringiensis and Bacillus sphaericus were investigated using in vitro enzyme assays and in vivo bioassay studies. It was observed that when a suspension of 'colloidal' chitin was added to a solution of Calcofluor White M2R there was a significant enhancement of fluorescence observed. Using this observation a plate-reader chitinase assay was developed and the activities of a range of B.thuringiensis strains were measured. A similar fluoresce

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Giannakopoulou, Artemis. "Approaches towards disease resistance to filamentous pathogens." Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/58580/.

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In the co-evolutionary arms race between plants and pathogens, plants have developed a multifaceted armory consisting of diverse defence responses, such as the production of antimicrobial compounds and the activation of immunity via specific receptors. This work examines the use of the phytoalexin capsidiol and synthetic NLR immune receptors as disease resistance approaches against oomycete and fungal plant pathogens. The production of phytoalexins constitutes an important aspect of plant defence. Capsidiol, a pepper phytoalexin, differentially inhibits the growth of two Phytophthora species,

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Anderson, Christopher. "Pathogens of cotton seedlings in NSW Australia." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12804.

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This study aimed to further expand understanding of the pathogens of cotton seedlings across NSW, and to identify pathogens associated with increased seedling mortality in southern NSW. A total of 230 organisms were recovered into pure culture from 192 locations and most screened for pathogenicity. The genera Rhizoctonia, Pythium, Fusarium, Macrophomina, and Sclerotium were isolated from diseased tissues and pathogens included R. solani anastomosis group (AG) 2-1, 2-2 IIIB, 3, 4 HG-I and 4 HG-III, Pythium sp., P. ultimum, P. helicoides and S. rolfsii. Pathogenicity of R. solani AG 3 and P. hel

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Gonzalez-Alanis, Pablo. "The Inactivation of Pathogens in Aquaculture Systems." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/195899.

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As aquaculture has become a significant provider of the human diet, the interest to have better quality of sea and fresh products has been increasing. However the potential hazards associated with pathogenic agents resulting in losses to the industry are major concerns that provided the motivation for this study.The use of ultraviolet irradiation is an alternative to disinfect water in inlet and outlet water sources. However the ultraviolet disinfection method has some drawbacks including no disinfectant residuals and high cost of lamp fouling and replacement. The ultraviolet system needs t

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Gherghisan-Filip, Cristina. "Engineering novel lantibiotics to target gut pathogens." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/63830/.

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Infections with multi-drug resistant bacteria are an urgent health security threat and bacteriocins such as the subclass of lantibiotics represent a promising alternative source to traditional antibiotics. The gut intestinal tract ecosystem has a complex set of bacteria with a huge bacteriogenic potential and it can be explored as a source for new lantibiotic peptides. Using a genome mining approach, a clos gene cluster that has the potential to encode for novel lantibiotics was previously discovered in a strain of Blautia isolated from the human gut. This clos operon may encode two nisin-like

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Volpe, Enrico <1987&gt. "Finfish and Human Pathogens in Bivalve Molluscs." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/8062/1/Tesi%20PhD_Volpe%20Enrico.pdf.

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Bivalve molluscs are an important food source for living beings, humans included. They are obligated filter feeders, that feed on microalgae, bacteria and organic particles present in the aquatic environment. Accordingly, they could accumulate chemical compounds, marine biotoxins, bacteria and viruses, including human and animal pathogens (Molloy et al., 2013; Serratore et al., 2014), influencing the epidemiology of animal and human infectious diseases (Skär & Mortensen, 2007). This topic has been long investigated for human pathogens. On the other hand, poor studies were available for finfis

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