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Thematische Bibliographien / Pertussis vaccines-Testing / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Pertussis vaccines-Testing“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Robinson, A., and S. G. P. Funnell. "Potency testing of acellular pertussis vaccines." Vaccine 10, no. 3 (1992): 139–41. http://dx.doi.org/10.1016/0264-410x(92)90001-z.

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2

Ausiello, C. M., R. Lande, P. Stefanelli, et al. "T-Cell Immune Response Assessment as a Complement to Serology and Intranasal Protection Assays in Determining the Protective Immunity Induced by Acellular Pertussis Vaccines in Mice." Clinical Diagnostic Laboratory Immunology 10, no. 4 (2003): 637–42. http://dx.doi.org/10.1128/cdli.10.4.637-642.2003.

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ABSTRACT The relative value of antibodies and/or T-cell immune responses to Bordetella pertussis antigens in the immunity induced by acellular pertussis (aP) vaccines is still an open issue, probably due to the incomplete knowledge on the mechanisms of protective immunity to pertussis. The relevance of T-cell immune responses in protection from pertussis has been demonstrated in murine and human models of infection; thus, in this study, the ability of different vaccine preparations of three component (pertussis toxin, filamentous hemagglutinin, and pertactin) aP vaccines to induce T-cell respo

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Dimeas, Ilias E., Ourania S. Kotsiou, Polyxeni Salgkami, et al. "Real-Life Insights into Pertussis Diagnosis: High Yield of PCR Testing and Clinical Outcomes—An Emerging Old Enemy or Just a Sign of PCR Times?" Journal of Personalized Medicine 14, no. 12 (2024): 1116. http://dx.doi.org/10.3390/jpm14121116.

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Background/Objectives: Pertussis remains a significant public health concern despite effective vaccines due to diagnostic challenges and symptom overlap with other respiratory infections. This study assesses the prevalence of Bordetella pertussis using advanced polymerase chain reaction (PCR) testing and examines the clinical outcomes over a one-month follow-up. Methods: We conducted a cross-sectional study at the University Hospital of Larissa, Greece, from April to June 2024, collecting 532 nasopharyngeal swabs from patients with respiratory symptoms. Diagnostic testing utilized the BioFire®

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Szymkowicz, Lisa, Jeffery Gerard, Benjamin Messham, Wai Tam, and D. James. "Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Bordetella pertussis Vaccines." Toxins 13, no. 11 (2021): 763. http://dx.doi.org/10.3390/toxins13110763.

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The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B. pertussis toxins that must be monitored as residuals during process optimization. This paper describes a liquid chromatography mass spectrometry (LC-MS) method for simultaneous analysis of residual protein toxins adenylate cyclase toxin (ACT) and dermonecrotic toxin (DNT), as well as a small molecule glycopeptide, tracheal cytotoxin (TCT) in a Pertussis toxin vaccine antigen. A targeted LC-MS

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Oh, Hokyung, Jeewon Joung, Byoung-Guk Kim, et al. "Improved protocols for histamine sensitization testing of acellular pertussis vaccines." Vaccine 30, no. 50 (2012): 7246–52. http://dx.doi.org/10.1016/j.vaccine.2012.10.005.

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Sesardic, D., C. S. Dawes, K. Mclellan, Z. Durrani, S. E. Yost, and M. J. Corbel. "Non-pertussis Components of Combination Vaccines: Problems with Potency Testing." Biologicals 27, no. 2 (1999): 177–81. http://dx.doi.org/10.1006/biol.1999.0205.

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Klein, David L. "Multicenter Acellular Pertussis Vaccine Trial: A National Institutes of Health Perspective." Pediatrics 96, no. 3 (1995): 547–48. http://dx.doi.org/10.1542/peds.96.3.547.

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The Pertussis Program within the Division of Microbiology and Infectious Diseases of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, is responsible for the development, management, and monitoring of several research and training initiatives in the field of pertussis. As directed by Congress through the National Childhood Injury Act, and with support by the National Vaccine Program Office, the NIAID has a mandate to accelerate scientifically and systematically the development and clinical testing of new candidate acellular pertussis vaccines, wi

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Hoonakker, Marieke Esther. "In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity." Toxins 13, no. 8 (2021): 565. http://dx.doi.org/10.3390/toxins13080565.

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One of the main virulence factors produced by Bordetella pertussis is pertussis toxin (PTx) which, in its inactivated form, is the major component of all marketed acellular pertussis vaccines. PTx ADP ribosylates Gαi proteins, thereby affecting the inhibition of adenylate cyclases and resulting in the accumulation of cAMP. Apart from this classical model, PTx also activates some receptors and can affect various ADP ribosylation- and adenylate cyclase-independent signalling pathways. Due to its potent ADP-ribosylation properties, PTx has been used in many research areas. Initially the research

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Saso, Anja, Beate Kampmann, and Sophie Roetynck. "Vaccine-Induced Cellular Immunity against Bordetella pertussis: Harnessing Lessons from Animal and Human Studies to Improve Design and Testing of Novel Pertussis Vaccines." Vaccines 9, no. 8 (2021): 877. http://dx.doi.org/10.3390/vaccines9080877.

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Pertussis (‘whooping cough’) is a severe respiratory tract infection that primarily affects young children and unimmunised infants. Despite widespread vaccine coverage, it remains one of the least well-controlled vaccine-preventable diseases, with a recent resurgence even in highly vaccinated populations. Although the exact underlying reasons are still not clear, emerging evidence suggests that a key factor is the replacement of the whole-cell (wP) by the acellular pertussis (aP) vaccine, which is less reactogenic but may induce suboptimal and waning immunity. Differences between vaccines are

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Pillsbury, Alexis, Helen E. Quinn, and Peter B. McIntyre. "Australian vaccine preventable disease epidemiological review series: pertussis, 2006–2012." Communicable Diseases Intelligence 38 (September 1, 2014): 179–94. https://doi.org/10.33321/cdi.2014.38.34.

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Despite pertussis vaccine being available since the 1940s and immunisation programs using combined diphtheria-tetanus-pertussis vaccine since the mid-1950s, pertussis has been the most commonly notified vaccine preventable disease in Australia over the past 20 years. Pertussis notification and hospitalisation data have been available nationally since 1993, and provide different perspectives for understanding epidemiological trends. This report follows on from a previous review of Australian pertussis epidemiology from 1995–2005 and summarises routinely collected notification, hospitalisation a

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Alekseeva, I. A., O. V. Perelygina, and E. D. Kolyshkina. "Estimation of production consistency of diphtheria, tetanus, and pertussis components of the DTP vaccine using Shewhart charts." BIOpreparations. Prevention, Diagnosis, Treatment 21, no. 4 (2021): 256–65. http://dx.doi.org/10.30895/2221-996x-2021-21-4-256-265.

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The Russian Federation puts special emphasis on vaccination-related issues, in accordance with the WHO recommendations. The fact that vaccination, in particular with the diphtheria, tetanus, and pertussis vaccine (DTP vaccine), covers large population groups, accounts for the relevance of research aimed at improving the quality of vaccines. One of the ways to produce vaccines of assured quality is to maintain consistent manufacturing processes that ensure consistency of product characteristics. The stability of the technological processes may be assessed using Shewhart charts. The aim of the s

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Hoonakker, Marieke, Juan Arciniega, and Coenraad Hendriksen. "Safety testing of acellular pertussis vaccines: Use of animals and 3Rs alternatives." Human Vaccines & Immunotherapeutics 13, no. 11 (2017): 2522–30. http://dx.doi.org/10.1080/21645515.2017.1349585.

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Saleem, Ahmed I., Amroo K. Noorelahi, Neven G. Zaki, and Sulafah T. Shaker. "Neonatal Pertussis in an Infant Born to an Immigrant Unimmunized Mother in Saudi Arabia." Journal of Clinical Neonatology 14, no. 2 (2025): 77–79. https://doi.org/10.4103/jcn.jcn_15_25.

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Pertussis is a highly contagious respiratory illness caused by the agent Bordetella pertussis. Despite reasonable vaccination coverage, there is a rise in the incidence of pertussis infection worldwide. In Saudi Arabia, 52% of pertussis infections occurred in infants younger than 6 months of age. Infants in this age group are especially vulnerable and can have fatal diseases particularly neonates, although pertussis is rare in the neonatal age group. The Centers for Disease Control and Prevention recommended that pregnant women should receive tetanus, diphtheria, and acellular pertussis vaccin

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Chisholm, Howe, Best, and Petousis-Harris. "Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study Protocol." Vaccines 7, no. 3 (2019): 65. http://dx.doi.org/10.3390/vaccines7030065.

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Pertussis vaccines have been effective at reducing pertussis-associated morbidity and mortality. However, they have a complex array of limitations, particularly associated with the duration of protection against clinical disease and imperfect immunity (carriage and transmission). Little is known about risk factors for pertussis vaccination failure. Understanding pertussis vaccination failure risk is most important in the paediatric population. This study aims to investigate risk factors for pertussis vaccination failure in (1) infants between birth and six weeks of age born to mothers who rece

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Knuutila, Aapo, Carita Rautanen, Jussi Mertsola, and Qiushui He. "Multiplex Point-of-Care Tests for the Determination of Antibodies after Acellular Pertussis Vaccination." Diagnostics 10, no. 4 (2020): 187. http://dx.doi.org/10.3390/diagnostics10040187.

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Most of the current serological diagnosis of pertussis is based on pertussis toxin (PT) IgG antibodies and does not differentiate between vaccination and infection-induced antibodies. PT is included in all of acellular pertussis vaccines available in the world. Multiplex testing of non-vaccine antigen-related antibodies has the potential to improve the diagnostic outcome of these assays. In this study, we developed a quantitatively spatial multiplex lateral flow immunoassay (LFIA) for the detection of IgG antibodies directed against PT, pertactin (PRN), and filamentous hemagglutinin (FHA). The

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Choi, Jung-Hyun, Jaime Correia de Sousa, Monica Fletcher, et al. "Improving vaccination rates in older adults and at-risk groups: focus on pertussis." Aging Clinical and Experimental Research 34, no. 1 (2022): 1–8. http://dx.doi.org/10.1007/s40520-021-02018-3.

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AbstractDespite the implementation of effective paediatric vaccination programmes, pertussis remains a global health problem. Disease epidemiology has changed over time, shifting towards the adolescent and adult populations. In adults, the true burden of pertussis is greatly underestimated and pertussis vaccine coverage rates are suboptimal, including individuals with chronic conditions. Here, we report the outcomes of a virtual international scientific workshop to assess the evidence on the burden of pertussis in older adults and identify potential solutions to improve uptake of pertussis vac

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Błaszczyszyn, Katarzyna, Monika Bolek, Katarzyna Muc, Natalia Hopej, Krzysztof Dobrzeniecki, and Kacper Turek. "pertussis paradox: why are cases increasing despite vaccination efforts?" Quality in Sport 16 (July 11, 2024): 52583. http://dx.doi.org/10.12775/qs.2024.16.52583.

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Introduction Pertussis, a highly transmissible respiratory infection mainly caused by Bordetella pertussis, remains one of the most widespread public health concerns despite the establishment of global vaccination initiatives. The disease manifests as paroxysmal coughing followed by a characteristic high-pitched “whooping” sound, and post-tussive vomiting. Severe complications can include pneumonia, encephalopathy, and even mortality, particularly in infants. Aim of the study This study aims to provide a comprehensive analysis of pertussis, encompassing its clinical presentation, complications

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Baxter, D. N., and A. C. C. Gibbs. "How are the sub-unit pertussis vaccines to be evaluated?" Epidemiology and Infection 99, no. 2 (1987): 477–84. http://dx.doi.org/10.1017/s0950268800067984.

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SUMMARYAlthough an effective whooping cough vaccine has been available in the UK since the 1950s, its current association with neurotoxicity has resulted in poor uptake: as a consequence major epidemics (with significant morbidity and mortality) arc still being experienced.Component (sub-unit) vaccines, which incorporate those antigens thought to be concerned with generating a protective effect, have been developed and are now available for field testing. This paper addresses how such a vaccine might be evaluated, the organization of a trial and the difficulties to be expected.

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Queenan, Anne Marie, Jeffrey Fernandez, Wenchi Shang, Selma Wiertsema, Germie PJM van den Dobbelsteen, and Jan Poolman. "The mouse intranasal challenge model for potency testing of whole-cell pertussis vaccines." Expert Review of Vaccines 13, no. 10 (2014): 1265–70. http://dx.doi.org/10.1586/14760584.2014.938642.

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Redhead, K., and Valerie Seagroatt. "The effects of purified components of bordetella pertussis in the weight gain test for the toxicity testing of pertussis vaccines." Journal of Biological Standardization 14, no. 1 (1986): 57–65. http://dx.doi.org/10.1016/s0092-1157(86)80009-9.

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Yount, Kacy S., Jamie Jennings-Gee, Sally Quataert, Rajendar Deora, and Purnima Dubey. "Intranasal immunization with an acellular pertussis vaccine containing a Th1/17 skewing adjuvant, BcfA, improves B. pertussis clearance from the mouse respiratory tract." Journal of Immunology 200, no. 1_Supplement (2018): 180.25. http://dx.doi.org/10.4049/jimmunol.200.supp.180.25.

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Abstract Bordetella pertussis is the causative agent of whooping cough, a resurging vaccine-preventable disease. This highly contagious disease is most severe in infants and young children. Current alum-adjuvanted acellular pertussis vaccines (aPV) prevent severe disease but do not prevent nasal carriage and subsequent person-to-person pathogen transmission. The Th1/2 skewed immune response induced by aPV is one potential explanation for this failure. We are testing the hypothesis that modification of current aPV by the addition of an adjuvant, BcfA, that skews immune responses towards the mor

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Henderson, D. A. "The miracle of vaccination." Notes and Records of the Royal Society of London 51, no. 2 (1997): 235–45. http://dx.doi.org/10.1098/rsnr.1997.0020.

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Among all medical procedures, vaccination ranks at the forefront in lives saved and disabling illnesses prevented. Jenner's first experiments with vaccination, 200 years ago, culminated in the eradication of smallpox at the conclusion of a ten–year World Health Organization programme begun in 1967. Two million lives were saved each year and tens of thousand of blindness cases. In 1974, the smallpox campaign was expanded to include six additional vaccines (poliomyelitis, measles, diphtheria, tetanus, pertussis and tuberculosis). By 1990, global vaccination coverage had risen from less than 5% t

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van der Maas, Larissa, Maarten Danial, Gideon F. A. Kersten, Bernard Metz, and Hugo D. Meiring. "Mass Spectrometry-Based Quantification of the Antigens in Aluminum Hydroxide-Adjuvanted Diphtheria-Tetanus-Acellular-Pertussis Combination Vaccines." Vaccines 10, no. 7 (2022): 1078. http://dx.doi.org/10.3390/vaccines10071078.

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Vaccines undergo stringent batch-release testing, most often including in-vivo assays for potency. For combination vaccines, such as diphtheria-tetanus-pertussis (DTaP), chemical modification induced by formaldehyde inactivation, as well as adsorption to aluminum-based adjuvants, complicates antigen-specific in-vitro analysis. Here, a mass spectrometric method was developed that allows the identification and quantitation of DTaP antigens in a combination vaccine. Isotopically labeled, antigen-specific internal standard peptides were employed that permitted absolute quantitation of their antige

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Komarovskaya, Е. I., and A. A. Soldatov. "Evaluation of the immune response to diphtheria and tetanus toxoids by the serological methods." Biological Products. Prevention, Diagnosis, Treatment 23, no. 3 (2023): 321–32. http://dx.doi.org/10.30895/2221-996x-2023-23-3-321-332.

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Scientific relevance. Currently, two types of methods are used to evaluate the potency of diphtheria and tetanus toxoids: the gold standard, which involves administering toxins to immunised animals, and serological methods, which involve quantifying protective antibodies in the serum of immunised animals. International validation studies of serological methods for assessing the potency of diphtheria and tetanus toxoids have resulted in revisions to the relevant chapters of the WHO Manual for Quality Control of Diphtheria, Tetanus and Pertussis Vaccines, as well as the European, Japanese, and s

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Poirier, Bertrand, Nicole Bornstein, Murielle Andre, et al. "Collaborative study for the establishment of a European Phamacopoeia biological reference preparation for Bordetella pertussis mouse antiserum for serological potency testing of acellular pertussis vaccines." Biologicals 31, no. 1 (2003): 25–38. http://dx.doi.org/10.1016/s1045-1056(02)00075-1.

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Capiau, Carine, Jan Poolman, Bernard Hoet, Hugues Bogaerts, and Francis Andre. "Development and clinical testing of multivalent vaccines based on a diphtheria–tetanus–acellular pertussis vaccine: difficulties encountered and lessons learned." Vaccine 21, no. 19-20 (2003): 2273–87. http://dx.doi.org/10.1016/s0264-410x(03)00107-5.

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Szeto, Jason, Aruun Beharry, Tricia Chen, et al. "Development of an In Vitro Test Method to Replace an Animal-Based Potency Test for Pertactin Antigen in Multivalent Vaccines." Vaccines 11, no. 2 (2023): 275. http://dx.doi.org/10.3390/vaccines11020275.

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There is increasing interest to replace animal-based potency assays used routinely to test vaccines, since they are highly variable, are costly, and present ethical concerns. The development of relevant in vitro assays is part of the solution. Using pertactin (PRN) antigen as an example in DTaP-IPV (diphtheria, tetanus, acellular pertussis, and inactivated poliovirus) vaccines, a PRN antigenicity ELISA was developed using two monoclonal antibodies with a high affinity to unique PRN epitopes, relevance to human immune responses, and evidence of functionality. The ELISA measured consistent PRN a

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Thysen, Sanne Marie, Manuel Fernandes, Christine Stabell Benn, Peter Aaby, and Ane Bærent Fisker. "Cohort profile : Bandim Health Project’s (BHP) rural Health and Demographic Surveillance System (HDSS)—a nationally representative HDSS in Guinea-Bissau." BMJ Open 9, no. 6 (2019): e028775. http://dx.doi.org/10.1136/bmjopen-2018-028775.

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PurposeBandim Health Project (BHP) monitors health and survival of women and children in a nationally representative rural Health and Demographic Surveillance System (HDSS) in Guinea-Bissau. The HDSS was set up in 1989–1990 to collect data on health interventions and child mortality.ParticipantsThe HDSS covers 182 randomly selected clusters across the whole country. The cohort is open, and women and children enter the cohort, when they move into the selected clusters, and leave the cohort, when they move out or die, or when children reach 5 years of age. Data are collected through biannual or

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Velikova, Tsvetelina, Hassan Ali, Latchezar Tomov, Tzvetan Velinov, and Snezhina Lazova. "Nasopharyngeal Colonization and Antimicrobial Susceptibility of Bacterial Isolates in Children and Young Adults with Acute, Protracted, and Chronic Cough: A Cross-Sectional Bulgarian Study." Acta Microbiologica Hellenica 70, no. 1 (2025): 10. https://doi.org/10.3390/amh70010010.

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Since the nasopharynx serves as an ecological niche for Streptococcus pneumoniae, Corynebacterium spp., Haemophilus influenzae, Moraxella catarrhalis, etc., colonization is influenced by antimicrobial treatments, host immune responses, viral infections, and vaccines, often leading to local and systemic infections. We aimed to investigate the patterns of nasopharyngeal colonization and antimicrobial susceptibility of bacterial isolates in Bulgarian individuals under 20 years of age presenting with acute, protracted, and chronic cough. We analyzed 1383 samples using conventional culture methods,

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Francois Watkins, Louise K., Jennifer L. Milucky, Lesley McGee,, et al. "Nasopharyngeal Carriage of Streptococcus pneumoniae Among Young Children in Haiti Before Pneumococcal Conjugate Vaccine Introduction." Journal of Infectious Diseases 224, Supplement_3 (2021): S248—S257. http://dx.doi.org/10.1093/infdis/jiab119.

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Abstract Background Streptococcus pneumoniae, or pneumococcus, is a leading cause of morbidity and mortality in children worldwide. Pneumococcal conjugate vaccines (PCV) reduce carriage in the nasopharynx, preventing disease. We conducted a pneumococcal carriage study to estimate the prevalence of pneumococcal colonization, identify risk factors for colonization, and describe antimicrobial susceptibility patterns among pneumococci colonizing young children in Port-au-Prince, Haiti, before introduction of 13-valent PCV (PCV13). Methods We conducted a cross-sectional study of children aged 6–24

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Inokuchi, Derek, Aparna Ramakrishnan, Karena F. Sapsis, and Allison L. Friedman. "Findings from Exploratory and Materials Testing Focus Groups with Korean American Parents regarding Preteen Vaccination and the 11- and 12-Year-Old Checkup." Social Marketing Quarterly 15, no. 1_suppl (2009): 118–35. http://dx.doi.org/10.1080/15245000902960940.

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In 2007, the Centers for Disease Control and Prevention (CDC) launched a new campaign for parents to promote three important vaccines for 11- and 12-year-old children: MCV4, which protects against meningococcal disease; Tdap, which protects against tetanus, diphtheria, and pertussis; and the HPV4 vaccine, which protects women against the types of human papillomavirus most commonly associated with cervical cancer and genital warts. The CDC is adapting these campaign materials for Korean Americans, who face significant barriers to accessing health information and experience high rates of cervica

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Friedrichs, Bärbel, Simone Rehg, Kay-Martin Hanschmann, Volker Öppling, and Isabelle Bekeredjian-Ding. "Determination of DTaP vaccine potency by multiplex immunogenicity testing using electrochemiluminescence." npj Vaccines 9, no. 1 (2024). http://dx.doi.org/10.1038/s41541-024-00915-y.

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AbstractLot release testing of diphtheria, tetanus and acellular pertussis vaccines traditionally relied on in vivo protection models involving challenge of laboratory animals with toxins. Meanwhile, many labs have switched to serological testing of these vaccines, which is often performed in separate in vivo assays, even if all components were formulated into one vaccine product. Here we describe the results of simultaneous serological potency determination of diphtheria (D), tetanus (T) and acellular pertussis (aP) antigens obtained following immunization of guinea pigs with multicomponent p

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Molenaar-de Backer, Marijke W. A., Paulien Doodeman, Fereshte Rezai, et al. "In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-39908-7.

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AbstractIntrinsic or added immune activating molecules are key for most vaccines to provide desired immunity profiles but may increase systemic reactogenicity. Regulatory agencies require rabbit pyrogen testing (RPT) for demonstration of vaccine reactogenicity. Recently, the monocyte activation test (MAT) gained popularity as in vitro alternative, yet this assay was primarily designed to test pyrogen-free products. The aim was to adjust the MAT to enable testing of pyrogen containing vaccines in an early stage of development where no reference batch is yet available. The MAT and RPT were compa

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Noel, Gaelle, Masoumeh Nakhost Lotfi, Sajedeh Mirshahvalad, et al. "Hospital-based prospective study of pertussis in infants and close contacts in Tehran, Iran." BMC Infectious Diseases 21, no. 1 (2021). http://dx.doi.org/10.1186/s12879-021-06266-6.

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Abstract Background Pertussis remain a global health concern, especially in infants too young to initiate their vaccination. Effective vaccination and high coverage limit the circulation of the pathogen, yet duration of protection is limited and boosters are recommended during a lifetime. In Iran, boosters are given at 18 months and 6 years old using whole pertussis vaccines for which efficacy is not known, and pertussis surveillance is scant with only sporadic biological diagnosis. Burden of pertussis is not well understood and local data are needed. Methods Hospital-based prospective study i

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Eby, Joshua C., Mary C. Gray, Jason M. Warfel, Tod J. Merkel, and Erik L. Hewlett. "Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis." Clinical and Vaccine Immunology 24, no. 1 (2016). http://dx.doi.org/10.1128/cvi.00370-16.

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ABSTRACT Adenylate cyclase toxin (ACT) is an essential virulence factor of Bordetella pertussis, and antibodies to ACT protect against B. pertussis infection in mice. The toxin is therefore a strong candidate antigen for addition to future acellular pertussis vaccines. In order to characterize the functionality of the immunologic response to ACT after infection, we developed an assay for testing the ability of serum samples from subjects infected with B. pertussis to neutralize ACT-induced cytotoxicity in J774 macrophage cells. Baboons develop neutralizing anti-ACT antibodies following infecti

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Furuichi, Mihoko, Tomohiro Katsuta, Yukitsugu Nakamura, Eisuke Suganuma, and Naoki Shimizu. "P-39. Trends in Pertussis Antibody Titers after DTaP Vaccination of Healthcare Workers at a Tertiary Children's Hospital in Japan." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.246.

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Abstract Background In Japan, diphtheria-tetanus-acellular pertussis (DTaP) is used for adults instead of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine. DTaP vaccinations for healthcare workers in obstetrics and pediatrics have been recommended since 2019 in Japan. However, data on the prevalence rate of pertussis antibodies among health care workers are limited. This study aims to evaluate pertussis antibody titers before and after DTaP vaccination to establish an optimal vaccination schedule for healthcare workers. Methods This study was a prospective obse

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Fu, Pan, Yijia Li, Jie Qin, Li Xie, Chao Yang, and Chuanqing Wang. "Molecular epidemiology and genomic features of Bordetella parapertussis in Shanghai, China, 2017–2022." Frontiers in Microbiology 15 (July 9, 2024). http://dx.doi.org/10.3389/fmicb.2024.1428766.

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BackgroundPertussis is a highly contagious respiratory illness mainly caused by Bordetella pertussis (BP). Bordetella parapertussis (BPP) can induce symptoms compatible with pertussis, but has been underdiagnosed and underreported. The current pertussis vaccines offer low protection against BPP. Herein, we aim to reveal the epidemiology and genomic evolution of BPP in Shanghai, China.MethodsChildren diagnosed with BPP infection from January 2017 to December 2022 in Shanghai, China were enrolled. We performed antimicrobial susceptibility testing (AST), multiple locus variable-number tandem repe

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He, Baohua, Zhaoyi Jia, Fei Zheng, et al. "Molecular characterization and antimicrobial susceptibility for 62 isolates of Bordetella pertussis from children." Frontiers in Microbiology 15 (December 11, 2024). https://doi.org/10.3389/fmicb.2024.1498638.

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BackgroundPertussis is a highly contagious respiratory disease caused by Bordetella pertussis (BP). Despite global control of pertussis cases through the Expanded Programme on Immunization (EPI), there has been a significant increase in the incidence of pertussis in recent years, characterized by a “resurgence” in developed countries with high immunization rates as well as a comparable reemergence in certain areas of China. We aim to explore the genotypes and antimicrobial susceptibility of circulating BP from children in Hebei.Study designChildren diagnosed with BP infection from 2019 to 2020

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Bahl, Dheeraj, Varun Alwadhi, Parasdeep Kaur, and Hema G. Mittal. "Impact of COVID-19 Pandemic on Routine Children Immunisation: Experience from a Tertiary Care Centre, in New Delhi, India." INDIAN JOURNAL OF NEONATAL MEDICINE AND RESEARCH, 2023. http://dx.doi.org/10.7860/ijnmr/2023/57574.2376.

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Introduction: Coronavirus Disease-2019 (COVID-19) pandemic was a global emergency in 2019 with multiphasic national lockdowns in most countries. Poor accessibility to travel and disease scare led to major fall in routine children vaccination. Aim: To study the impact of COVID-19 pandemic on routine children immunisation at a tertiary care centre in New Delhi, India. Materials and Methods: This retrospective cross-sectional study was carried out in May and June 2022, by collecting retrospective data from Immunisation Clinic of Paediatric Department of Dr. Ram Manohar Lohia hospital, a tertiary

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Anraad, Charlotte, Pepijn van Empelen, Robert A. C. Ruiter, Marlies Rijnders, Katja van Groessen, and Hilde M. van Keulen. "Promoting informed decision making about maternal pertussis vaccination: the systematic development of an online tailored decision aid and a centering-based group antenatal care intervention." Frontiers in Public Health 12 (February 15, 2024). http://dx.doi.org/10.3389/fpubh.2024.1256337.

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IntroductionMaintaining and enhancing vaccine confidence continues to be a challenge. Making an informed decision not only helps to avoid potential future regret but also reduces susceptibility to misinformation. There is an urgent need for interventions that facilitate informed decision-making about vaccines. This paper describes the systematic development of two interventions designed to promote informed decision making and indirectly, acceptance of maternal pertussis vaccination (MPV) in the Netherlands.Materials and methodsThe 6-step Intervention Mapping (IM) protocol was used for the deve

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Zorina, Veronika. "The molecular mimicry and COVID-19." Russian Journal of Infection and Immunity, September 1, 2023. http://dx.doi.org/10.15789/2220-7619-tmm-8878.

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A significant part of the complications of COVID-19 and manifestations of post-COVID syndrome is associated with autoimmune reactions caused by SARS-CoV-2. The key mechanism for the implementation of autoimmunity in COVID-19 is molecular mimicry, which is involved in the development of a cytokine storm, systemic multiorgan hyperinflammation, endothelial dysfunction, and is also a trigger for the development of autoimmune diseases (autoimmune thrombocytopenia, autoimmune vasculitis, Guillain-Barr syndrome, Miller-Fisher syndrome, autoimmune neuropathy, autoimmune thyroiditis, rheumatoid arthrit

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Ameku, W.A., V.N. Ataide, E.T. Costab, et al. "A pencil-lead immunosensor for the rapid electrochemical measurement of anti-Diphtheria Toxin antibodies." October 30, 2021. https://doi.org/10.5281/zenodo.5628477.

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<strong>Abstract: </strong>Diphtheria is a vaccine-preventable disease, yet immunization can wane over time to non-protective levels. We have developed a low-cost, miniaturized electroanalytical biosensor to quantify anti-diphtheria toxin (DTx) immunoglobulin G (IgG) antibody to minimize the risk for localized outbreaks. Two epitopes specific to DTx and recognized by antibodies generated post-vaccination were selected to create a bi-epitope peptide, biEP, by synthesizing the epitopes in tandem. The biEP peptide was conjugated to the surface of a pencil-lead electrode (PLE) integrated into a po

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