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Thematische Bibliographien / Pharmacokinetics / Dissertationen

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Dissertationen zum Thema „Pharmacokinetics“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 25. Juli 2025

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1

Chigutsa, Emmanuel. "Population pharmacokinetics and pharmacokinetic-pharmacodyamic modeling of antitubercular drugs." Doctoral thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/3275.

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Includes abstract.<br>Includes bibliographical references.<br>The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in 78 patients with tuberculosis were described using non-linear mixed effects modeling. Pharmacodynamic data was comprised of weekly sputum liquid culture (using mycobacterial growth indicator tubes) time to detection results from 144 patients during the first 2 months of treatment. The effect of drug exposure on patient outcomes was investigated. To determine the adequacy of ofloxacin drug exposure, the probability of attaining the required area-under-the-c

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2

Ulrich-Oppliger, Brigitte Madeleine. "Pharmacokinetics /." Bern, 1992. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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3

Charter, Mark Keith. "Maximum entropy pharmacokinetics." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316691.

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4

Smith, Jennifer Lisa. "Pharmacokinetics of methylamines." Thesis, Massachusetts Institute of Technology, 1992. http://hdl.handle.net/1721.1/12906.

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5

Khosravan, Reza. "Nonlinear pharmacokinetics of diltiazem." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0030/NQ46865.pdf.

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6

Al-Mustafa, Z. H. "Methotrexate pharmacokinetics and toxicity." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383988.

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7

Woodhouse, Jennifer Ann. "Plutonium pharmacokinetics and blood biochemistry." Thesis, University of Central Lancashire, 1997. http://clok.uclan.ac.uk/20148/.

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Since its discovery in the early 1940s the element plutonium has been seen by mankind as both an opportunity and a threat. As a radioactive nuclide plutonium presents health hazards in its handling and if mankind is to make the most of this element's potential benefits it is essential that these hazards be understood. Both overestimation and underestimation of these hazards are damaging to its proper utilisation. Many studies have been carried out to determine the effects of plutonium exposure and a broad picture of the biological behaviour of plutonium has been built up. Radiological protecti

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8

Smith, Adam John. "Modulating the Pharmacokinetics of Bioflavonoids." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4226.

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One of the largest obstacles in drug development is to overcome solubility and bioavailability problems. Preformulation strategies such as nanoparticle formation are often employed but sometimes create new issues and are limited in their effectiveness and applications. Since the majority of drugs are marketed and sold as solid forms, drug delivery systems are not always desirable. This is where solid-state chemistry becomes important. Traditional solid-state chemistry approaches are often successful but are sometimes too restrictive and cannot be applied to certain compounds. Cocrystals h

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9

Harper, Kenneth W. "Pharmacokinetics of methohexitone and midazolam." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254195.

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10

Evans, Gary Lee. "Pharmacokinetics and metabolism of lacidipine." Thesis, University of Hertfordshire, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387196.

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11

Ahsan, Chowdhury Hafizul. "Pharmacokinetics of nifedipine in humans." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303154.

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12

Richards, Robert. "The pharmacokinetics of sodium cromoglycate." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359034.

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13

Bester, Lynette. "Pharmacokinetics of propofol in cats." Diss., University of Pretoria, 2009. http://hdl.handle.net/2263/22954.

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Since the introduction of the lipid emulsion formulation in 1986, propofol has become established for induction as well as for maintenance of anaesthesia in veterinary practice1 including cats2;3-8. Propofol is rapidly metabolized by hepatic glucuronidation in most species and it has also been shown to undergo extrahepatic metabolism9-13, so that total body clearance may exceed liver blood flow in certain species. Because of their highly carniverous diet, cats are little exposed to antiherbivory compounds so that they have become deficient in UGP-glucuronosyltransferase (UGT)14. Consequently,

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14

Tongaree, Sauwaluxana. "Vancomycin pharmacokinetics : development and assessment." Scholarly Commons, 1991. https://scholarlycommons.pacific.edu/uop_etds/2224.

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An evaluation of vancomycin pharmacokinetics was performed in 2 phases. In phase I, a vancomycin population pharmacokinetic model was developed based on data from 126 patients using a two-compartment model. Variables tested for inclusion in the model were creatinine clearance (Crcl), age, total body weight (wt) ICU status, gender, body surface area, ideal weight and height. Variables were included at the P < _ 0. 05 level. The final population pharmacokinetic model was as follows: Cl (L/hr) = (0.025 * Crcl) * (1 + 0.0165 *age), V1 (L) = 29.5, V2 (L) = 8.17 + 0.349 * Crcl and Q (L/hr.kg) = 0. 0

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15

Bester, Lynette. "Pharmacokinetics of propofol in cats." Pretoria : [s.n.], 2021. http://upetd.up.ac.za/thesis/available/etd-03032010-184513/.

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16

Dragula, Collen Elizabeth 1964. "A pharmacokinetic study of acrylamide and theophylline in rats." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276847.

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Effects of age, dosage regimen, dose level, and routes of administration on the pharmacokinetics of acrylamide (ACR) and theophylline (TP) in Fischer 344 rats have been studied. ACR treatment consisted of administration of a single subtoxic dose or of multiple doses known to induce neurotoxicity to 5 and 11 week old rats. The effects of age and dosing regimen on the determination of pharmacokinetic parameters were studied. Multiply dosed rats had significantly longer plasma half lives than the singly dosed animals. Clearance values in the plasma were also significantly decreased following mult

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17

Olsén, Lena. "Drugs in horses : pharmacokinetics and pharmacodynamics /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200737.pdf.

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18

Tärning, Joel. "Piperaquine : bioanalysis, drug metabolism and pharmacokinetics /." Göteborg: Institute of Neuroscience and Physiology, Dept. of Pharmacology, the Sahlgrenska Academy at Göteborg University, 2007. http://hdl.handle.net/2077/7196.

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19

Siccardi, Marco. "Genetic determinants of key antiretroviral pharmacokinetics." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569560.

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Antiretroviral pharmacokinetics is one of the most important predictors of therapy efficacy and correlations between virological suppression and plasma concentrations have been described for all antiretroviral classes. Plasma concentrations are the result of absorption, distribution, metabolism and elimination (AD ME) processes which are mediated by numerous proteins in different tissues. Single nucleotide polymorphisms (SNPs) in genes encoding for individual proteins may be an important determinants drug exposure. The aim of this thesis was to characterise the role of some key SNPs determinin

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20

Khazal, Kamel F. "Chloramphenicol pharmacokinetics and metabolism in dogs /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487267024996335.

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21

Song, Di. "Bladder tissue pharmacokinetics of anticancer drugs /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487940308433249.

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22

Arends, Rosalinda Helena Gerardus Petronella. "Pharmacokinetics and pharmacodynamics of opioid analgesics /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/7955.

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23

Wright, Abra M. "Pharmacokinetics of pergolide in normal mares." Thesis, Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1548.

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24

Eriksson, Tommy. "Pharmacokinetics of the enantionmers of thalidomide." Malmö : Lund : Malmö University Hospital ; Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/68945032.html.

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25

Walker, Roderick Bryan. "HPLC analysis and pharmacokinetics of cyclizine." Thesis, Rhodes University, 1995. http://hdl.handle.net/10962/d1003279.

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The investigations detailed in this dissertation have been conducted to address the paucity of pharmacokinetic information, in published literature, pertaining to cyclizine. The areas of investigation have included the selective quantitation of both cyclizine and its demethylated metabolite, norcyclizine in serum and urine, assessment of stability of both compounds in stored biological samples, dosage form analysis, dissolution rate testing of tablets, and bioavailability and pharmacokinetics following administration of an intravenous solution, and tablets to humans. High-performance liquid ch

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26

Rigby, Justin Holbrook. "Pharmacokinetics of Dexamethasone Delivered via Iontophoresis." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3895.

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Study Design: Controlled laboratory study. Objectives: To determine the time course of dexamethasone sodium phosphate (Dex-P) iontophoresis delivery to underlying tissues using microdialysis. Background: The efficacy of iontophoresis at delivering Dex-P through the skin is unknown in humans because of the lack of minimally invasive measurement techniques. Methods: Sixty-four healthy male participants (age = 24.4 ± 3.3 yrs, height = 71.8 ± 2.5 in, weight = 181.8 ± 26.1 lbs) were randomly assigned into one of six groups: 1) 1 mA current, 1 mm probes depth ; 2) 1 mA current, 4 mm probes depth; 3)

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27

Methaneethorn, Janthima. "Population pharmacokinetics and pharmacodynamics of pyronaridine." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4876.

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Pyronaridine/Artesunate (PA) 3:1 fixed dose combination is a novel artemisinin-based combination therapy (ACT) in development for the treatment of acute uncomplicated Plasmodium falciparum or Plasmodium vivax malaria. An understanding of both pharmacokinetics and pharmacodynamics of pyronaridine is of importance in order to achieve optimal therapeutic outcome. In this thesis, population pharmacokinetic models for pyronaridine in healthy subjects, and adult and pediatric malaria patients were developed. Pyronaridine pharmacokinetics

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28

Pigatto, Maiara Cássia. "Modelagem PK/PD do efeito anticancerígeno do etoposídeo em ratos com tumor de walker-256 utilizando concentrações livres intratumorais determinaas por microdiálise." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/148189.

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Objetivo: O objetivo do presente estudo foi descrever a relação entre as concentrações plasmáticas totais e livres tumorais do etoposídeo (ETO) e a inibição do crescimento do tumor observada em ratos Wistar portadores de tumor Walker- 256 (W256) utilizando a modelagem farmacocinética/farmacodinâmica (PK/PD). Métodos: Os procedimentos com animais foram aprovados no CEUA/UFRGS sob o número 22302. Os experimentos de farmacocinética foram realizados para determinar concentrações plasmáticas e livres em duas regiões do tumor sólido W256 através de microdiálise. Após a administração do ETO nas doses

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29

Reddingius, Wieb Reddingius Wiebrandus Gerardus. "Bioanalysis and pharmacokinetics of fumarates in humans /." [S.l.] : [s.n.], 1997. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12199.

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30

Hu, Leijun. "Suramin pharmacokinetics after regional or systemic administration." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1114449390.

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31

Hasegawa, Takaaki, Kenji Takagi, and Kiyoyuki Kitaichi. "Effects of Bacterial Endotoxin on Drug Pharmacokinetics." 名古屋大学医学部, 1999. http://hdl.handle.net/2237/6203.

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32

Penson, Richard Thomas. "The morphine glucuronides : pharmacokinetics, pharmacodynamics and interactions." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406201.

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33

Pullen, Joyce. "Pharmacokinetics and dosing of antibiotics in neonates." [Maastricht] : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=8305.

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34

Ekborn, Andreas. "Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-721-5.

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35

Turner, Joe. "Application of artificial neural networks in pharmacokinetics /." Connect to full text, 2003. http://setis.library.usyd.edu.au/adt/public_html/adt-NU/public/adt-NU20031007.090937/index.html.

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36

Chan, Hui Min Ravis William R. "Pharmacokinetics of Voriconazole in horses and alpacas." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SPRING/Pharmacal_Sciences/Dissertation/Chan_Hui_20.pdf.

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37

Rahman, Nargis Jahan. "Incorporation of population pharmacokinetics into drug development." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325239.

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38

Konsue, Nattaya. "Pharmacokinetics and chemopreventive potential of phenethyl isothiocyanate." Thesis, University of Surrey, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511107.

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39

李富榮 and Foo-wing Lee. "Pharmacokinetics of homoharringtonine in Chinese leukemia patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31209233.

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40

Davies, Geraint Rhys. "Pharmacokinetics and pharmacodynamics of anti-tuberculosis chemotherapy." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502576.

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For the first time in thirty years the tuberculosis drug development pipeline may be on the verge of delivering ultra-short course chemotherapy but continued reliance on relapse rates in clinical trials and limited understanding ofthe phenomenon ofpersistence ofM tuberculosis during treatment have made the critical pathway of early clinical development uncertain. It is demonstrated here that serial sputum colony counting,prolonged throughout the first two months oftreatment and analysed using hierarchical non-linear regression techniques has the power to detect treatment differences between co

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41

Al-Mehsen, Fahad A. "Clinical pharmacokinetics of antibiotics in cystic fibrosis." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336044.

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42

Chen, An Ge. "The pharmacokinetics of imipramine in Chinese subjects." Thesis, Liverpool John Moores University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298148.

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43

Lankford, William Timothy. "The toxicity and pharmacokinetics of pyrethroid microemulsions." Thesis, Nottingham Trent University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384861.

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44

Kamali, F. "Metabolism and pharmacokinetics of paracetamol in man." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355292.

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45

Chan, E. W.-Y. "Warfarin : Stereochemical aspects of pharmacokinetics and response." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374525.

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46

Wattanatorn, Wiboon. "Pharmacokinetics of 5-fluorouracil in cancer patients." Thesis, Robert Gordon University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389482.

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47

Catterall, Fenton Scott. "The biological activity and pharmacokinetics of polyphenols." Thesis, University of Surrey, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365156.

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48

Devine, Elizabeth P. "Pharmacokinetics of intramuscular morphine in the horse." Kansas State University, 2012. http://hdl.handle.net/2097/13864.

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Master of Science<br>Department of Clinical Sciences<br>Warren L. Beard<br>Pharmacokinetics of Intramuscular Morphine in the Horse Elizabeth Devine, DVM; Butch KuKanich, DVM, PhD, DACVCP; Warren Beard, DVM, MS, DACVS Objective - To determine the pharmacokinetics of morphine after intramuscular administration in a clinical population of horses Design – Prospective, clinical study Animals – Pilot study included 2 normal horses and the clinical study included 75 horses Procedures – Morphine was administered at 0.1mg/kg, IM and 2-3 blood samples were obtained from each horse at various times

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49

Merhar, Stephanie L. M. D. "Pharmacokinetics of levetiracetam in neonates with seizures." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1305030096.

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50

Gordon, Bentley Horatio. "The pharmacokinetics and metabolism of almitrine bismesylate." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/34361.

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Almitrine Bismesylate (ABM) is a highly lipophillic compound of molecular weight 669.7, under development as a peripheral chemoreceptor stimulant in the treatment of chronic bronchitis and emphysema. Its pharmacokinetics and metabolism were investigated in animals and man. Following oral administration of [14C]-ABM, absorption of radioactivity is rapid and variable in man, rat, rabbit and dog. Plasma levels of radioactivity decline rapidly after both oral and intravenous administration, suggesting rapid uptake into tissues. A high affinity of almitrine for the carotid body of the urethane-anae

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