Einloggen

Thematische Bibliographien / Placenta – Physiologie / Zeitschriftenartikel

Um die anderen Arten von Veröffentlichungen zu diesem Thema anzuzeigen, folgen Sie diesem Link: Placenta – Physiologie.

Zeitschriftenartikel zum Thema „Placenta – Physiologie“

Autor: Grafiati

Veröffentlicht am 29. März 2025

Zuletzt aktualisiert am 31. Juli 2025

Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an

Wählen Sie eine Art der Quelle aus:

Machen Sie sich mit Top-50 Zeitschriftenartikel für die Forschung zum Thema "Placenta – Physiologie" bekannt.

Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.

Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.

Sehen Sie die Zeitschriftenartikel für verschiedene Spezialgebieten durch und erstellen Sie Ihre Bibliographie auf korrekte Weise.

1

Taher, Shèdy, Yamilette Borja, Lucía Cabanela, et al. "Cholecystokinin, gastrin, cholecystokinin/gastrin receptors, and bitter taste receptor TAS2R14: trophoblast expression and signaling." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 316, no. 5 (2019): R628—R639. http://dx.doi.org/10.1152/ajpregu.00153.2018.

Der volle Inhalt der Quelle

Annotation:

We investigated expression of cholecystokinin (CCK) in humans and mice, and the bitter taste receptor TAS2R14 in the human placenta. Because CCK and gastrin activate the CCKBR receptor, we also explored placental gastrin expression. Finally, we investigated calcium signaling by CCK and TAS2R14. By RT-PCR, we found CCK/Cck and GAST/Gast mRNA expression in both normal human and mouse placentas, as well as in human trophoblast cell lines (TCL). Although both Cckar and – br mRNA were expressed in the mouse placenta, only CCKBR mRNA was detected in the human placenta and TCL. mRNA expression for TA

APA, Harvard, Vancouver, ISO und andere Zitierweisen

2

Lien, Yu-Chin, Zhe Zhang, Yi Cheng, et al. "Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth." International Journal of Molecular Sciences 22, no. 15 (2021): 7899. http://dx.doi.org/10.3390/ijms22157899.

Der volle Inhalt der Quelle

Annotation:

A well-functioning placenta is crucial for normal gestation and regulates the nutrient, gas, and waste exchanges between the maternal and fetal circulations and is an important endocrine organ producing hormones that regulate both the maternal and fetal physiologies during pregnancy. Placental insufficiency is implicated in spontaneous preterm birth (SPTB). We proposed that deficits in the capacity of the placenta to maintain bioenergetic and metabolic stability during pregnancy may ultimately result in SPTB. To explore our hypothesis, we performed a RNA-seq study in male and female placentas

APA, Harvard, Vancouver, ISO und andere Zitierweisen

3

Osifo, E. O., and V. C. Ezeuko. "Histological Assessment of Placental Development Following Intrauterine Exposure to Caffeine in Adult Wistar Rats." Journal of Applied Sciences and Environmental Management 28, no. 4 (2024): 1115–20. http://dx.doi.org/10.4314/jasem.v28i4.11.

Der volle Inhalt der Quelle

Annotation:

In recent years, there have been concerns about human reproductive disorders. Physiological adaptations are crucial for optimal fetal development during pregnancy. The widespread consumption of caffeine by pregnant women raises questions about its impact on maternal physiology and fetal development. Hence, the objective of this study was to evaluate the histological assessment of placenta development following intrauterine exposure to caffeine in adult Wistar rats using appropriate standard techniques. On each gestational day (GD13, GD15, GD17, and GD19), five (5) animals were sampled from eac

APA, Harvard, Vancouver, ISO und andere Zitierweisen

4

Rampon, Christine, Stéphanie Bouillot, Adriana Climescu-Haulica, et al. "Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta." Physiological Genomics 34, no. 2 (2008): 193–204. http://dx.doi.org/10.1152/physiolgenomics.00220.2007.

Der volle Inhalt der Quelle

Annotation:

Protocadherins are transmembrane proteins exhibiting homophilic adhesive activities through their extracellular domain. Protocadherin 12 ( Pcdh12) is expressed in angiogenic endothelial cells, mesangial cells of kidney glomeruli, and glycogen cells of the mouse placenta. To get insight into the role of this protein in vivo, we analyzed PCDH12-deficient mice and investigated their placental phenotype. The mice were alive and fertile; however, placental and embryonic sizes were reduced compared with wild-type mice. We observed defects in placental layer segregation and a decreased vascularizatio

APA, Harvard, Vancouver, ISO und andere Zitierweisen

5

Selvaratnam, Johanna, Haiyan Guan, James Koropatnick, and Kaiping Yang. "Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction." American Journal of Physiology-Endocrinology and Metabolism 305, no. 6 (2013): E727—E735. http://dx.doi.org/10.1152/ajpendo.00157.2013.

Der volle Inhalt der Quelle

Annotation:

Maternal cadmium exposure induces fetal growth restriction (FGR), but the underlying mechanisms remain largely unknown. The placenta is the main organ known to protect the fetus from environmental toxins such as cadmium. In this study, we examine the role of the two key placental factors in cadmium-induced FGR. The first is placental enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which is known to protect the fetus from exposure to high cortisol levels and subsequently FGR, and the second the cadmium binding/sequestering proteins metallotheionein (MT)-I and -II. Using the MT-I/II −

APA, Harvard, Vancouver, ISO und andere Zitierweisen

6

Flores-Pliego, Arturo, Jael Miranda, Sara Vega-Torreblanca, et al. "Molecular Insights into the Thrombotic and Microvascular Injury in Placental Endothelium of Women with Mild or Severe COVID-19." Cells 10, no. 2 (2021): 364. http://dx.doi.org/10.3390/cells10020364.

Der volle Inhalt der Quelle

Annotation:

Clinical manifestations of coronavirus disease 2019 (COVID-19) in pregnant women are diverse, and little is known of the impact of the disease on placental physiology. Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has been detected in the human placenta, and its binding receptor ACE2 is present in a variety of placental cells, including endothelium. Here, we analyze the impact of COVID-19 in placental endothelium, studying by immunofluorescence the expression of von Willebrand factor (vWf), claudin-5, and vascular endothelial (VE) cadherin in the decidua and chorionic villi of pla

APA, Harvard, Vancouver, ISO und andere Zitierweisen

7

Vaughan, Owen R., Fredrick Thompson, Ramón A. Lorca, et al. "Effect of high altitude on human placental amino acid transport." Journal of Applied Physiology 128, no. 1 (2020): 127–33. http://dx.doi.org/10.1152/japplphysiol.00691.2019.

Der volle Inhalt der Quelle

Annotation:

Women residing at high altitudes deliver infants of lower birth weight than at sea level. Birth weight correlates with placental system A-mediated amino acid transport capacity, and severe environmental hypoxia reduces system A activity in isolated trophoblast and the mouse placenta. However, the effect of high altitude on human placental amino acid transport remains unknown. We hypothesized that microvillous membrane (MVM) system A and system L amino acid transporter activity is lower in placentas of women living at high altitude compared with low-altitude controls. Placentas were collected a

APA, Harvard, Vancouver, ISO und andere Zitierweisen

8

Assad, R. S., F. Y. Lee, and F. L. Hanley. "Placental compliance during fetal extracorporeal circulation." Journal of Applied Physiology 90, no. 5 (2001): 1882–86. http://dx.doi.org/10.1152/jappl.2001.90.5.1882.

Der volle Inhalt der Quelle

Annotation:

The fetus requires large amounts of volume when weaning from cardiac bypass. This suggests that placental vasculature can act as a large capacitor in the fetal circulation. To assess placental compliance of fetal lambs, seven isolated in situ lamb placentas were placed on extracorporeal circulation. Umbilical artery blood flow was varied from 0 to 350 ml · min−1· kg fetal wt−1. Because the extracorporeal circuit is a closed system, volume changes in the placenta induced by umbilical artery pressure changes were measured from reciprocal volume changes in the reservoir. There was a wide range of

APA, Harvard, Vancouver, ISO und andere Zitierweisen

9

Shanes, Elisheva D., Leena B. Mithal, Sebastian Otero, Hooman A. Azad, Emily S. Miller, and Jeffery A. Goldstein. "Placental Pathology in COVID-19." American Journal of Clinical Pathology 154, no. 1 (2020): 23–32. http://dx.doi.org/10.1093/ajcp/aqaa089.

Der volle Inhalt der Quelle

Annotation:

Abstract Objectives To describe histopathologic findings in the placentas of women with coronavirus disease 2019 (COVID-19) during pregnancy. Methods Pregnant women with COVID-19 delivering between March 18, 2020, and May 5, 2020, were identified. Placentas were examined and compared to historical controls and women with placental evaluation for a history of melanoma. Results Sixteen placentas from patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were examined (15 with live birth in the third trimester, 1 delivered in the second trimester after intrauterine fetal demi

APA, Harvard, Vancouver, ISO und andere Zitierweisen

10

Tissot van Patot, M. C., J. Bendrick-Peart, V. E. Beckey, N. Serkova, and L. Zwerdlinger. "Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia." American Journal of Physiology-Lung Cellular and Molecular Physiology 287, no. 3 (2004): L525—L532. http://dx.doi.org/10.1152/ajplung.00203.2003.

Der volle Inhalt der Quelle

Annotation:

Vascularity is increased in placentas from high- compared with low-altitude pregnancies. An angiogenic response to hypoxia may protect an organ from further hypoxic insult by increasing blood flow and oxygen delivery to the tissue. We hypothesized that increased placental vascularity is sufficient to adapt to high altitude. Therefore, indexes of hypoxic stress would not be present in placentas from successful high-altitude pregnancies. Full-thickness placental biopsies were 1) collected and frozen in liquid nitrogen within 5 min of placental delivery and 2) fixed in formalin for stereologic an

APA, Harvard, Vancouver, ISO und andere Zitierweisen

11

Ordoñez, Maria Victoria, Giovanni Biglino, Massimo Caputo, et al. "Case of placental insufficiency and premature delivery in a Fontan pregnancy: physiological insights and considerations on risk stratification." Open Heart 8, no. 1 (2021): e001211. http://dx.doi.org/10.1136/openhrt-2019-001211.

Der volle Inhalt der Quelle

Annotation:

ObjectivesThe coexistence of two complex physiologies such as Fontan and pregnancy is still not fully understood. We aim to add a unique and essential knowledge to help our colleagues in the management of Fontan patients that undergo pregnancy as well as the fetus and the placenta perfusion.Methods and resultsWe analyse the coexistence of Fontan and pregnancy physiology on a complex case of a woman with hypoplastic left heart syndrome palliated with a univentricular repair who became pregnant, delivered very prematurely and had atypical placental findings.ConclusionHistopathological analysis o

APA, Harvard, Vancouver, ISO und andere Zitierweisen

12

Gardner, Sarah, Jennifer L. Grindstaff, and Polly Campbell. "Placental genotype affects early postpartum maternal behaviour." Royal Society Open Science 6, no. 9 (2019): 190732. http://dx.doi.org/10.1098/rsos.190732.

Der volle Inhalt der Quelle

Annotation:

The mammalian placenta is a source of endocrine signals that prime the onset of maternal care at parturition. While consequences of placental dysfunction for offspring growth are well defined, how altered placental signalling might affect maternal behaviour is unstudied in a natural system. In the cross between sympatric mouse species, Mus musculus domesticus and Mus spretus , hybrid placentas are undersized and show misexpression of genes critical to placental endocrine function. Using this cross, we quantified the effects of placental dysregulation on maternal and anxiety-like behaviours in

APA, Harvard, Vancouver, ISO und andere Zitierweisen

13

SIMCHENKO, A. V., O. A. ALEXEY, and A. A. KUPRASHVILI. "MITOCHONDRIAL DYSFUNCTION IN THE GENESIS OF PLACENTAL PATHOLOGY: PERINATAL OUTCOMES." MODERN PERINATAL MEDICAL TECHNOLOGIES IN SOLVING THE PROBLEM OF DEMOGRAPHIC SECURITY, no. 17 (December 2024): 357–61. https://doi.org/10.63030/2307-4795/2024.17.p.24.

Der volle Inhalt der Quelle

Annotation:

The human placenta is a unique organ with a temporary functioning period of about 280 days on average. All changes associated with the physiology of mitochondria, the aging process of the placenta, adaptation to changing conditions or dysfunction of the placenta directly affect the performance of the placenta's functions, as well as the development of the fetus. Modern studies studying the causes of intrauterine growth disorders of the fetus demonstrate the implementation of a chain of mechanisms of placental dysfunction, which leads to a slowdown in fetal growth with a subsequent slowdown in

APA, Harvard, Vancouver, ISO und andere Zitierweisen

14

Levy, RA, E. Avvad, J. Oliveira, and LC Porto. "Placental pathology in antiphospholipid syndrome." Lupus 7, no. 2_suppl (1998): 81–85. http://dx.doi.org/10.1177/096120339800700218.

Der volle Inhalt der Quelle

Annotation:

One of the major targets of antiphospholipid antibodies (aPL) is the placenta, the evolution of which during pregnancy has been well documented. Histopathological findings are related to gestational age, and several physiologic and pathologic alterations that occur during its development. The major findings in placentae from aPL positive patients are thrombosis, acute atherosis, a decreased number of syncytio-vascular membranes, increased number of syncytial knots and obliterative arteriopathy. These findings are not specific to the antiphospholipid syndrome (APS) and sometimes do not correlat

APA, Harvard, Vancouver, ISO und andere Zitierweisen

15

Makaroun, Sami, and Katherine Himes. "Differential Methylation of Syncytin-1 and 2 Distinguishes Fetal Growth Restriction from Physiologic Small for Gestational Age." American Journal of Perinatology Reports 08, no. 01 (2018): e18-e24. http://dx.doi.org/10.1055/s-0038-1627473.

Der volle Inhalt der Quelle

Annotation:

Objective The retroviral genes encoding Syncytin-1 (SYN1) and Syncytin-2 (SYN2) are epigenetically regulated, uniquely expressed in the placenta and critical to placental function. We sought to determine if placental expression and methylation patterns of SYN1 and SYN2 from pregnancies complicated by fetal growth restriction (FGR) differed from physiologic small for gestational age (SGA) and appropriate for gestational age (AGA) controls. Study Design Placental biopsies were obtained from AGA, SGA and FGR neonates delivered at >36 weeks gestation. SGA and FGR were defined as birth weight &l

APA, Harvard, Vancouver, ISO und andere Zitierweisen

16

Roberts, R. Michael, Jonathan A. Green, and Laura C. Schulz. "The evolution of the placenta." Reproduction 152, no. 5 (2016): R179—R189. http://dx.doi.org/10.1530/rep-16-0325.

Der volle Inhalt der Quelle

Annotation:

The very apt definition of a placenta is coined by Mossman, namely apposition or fusion of the fetal membranes to the uterine mucosa for physiological exchange. As such, it is a specialized organ whose purpose is to provide continuing support to the developing young. By this definition, placentas have evolved within every vertebrate class other than birds. They have evolved on multiple occasions, often within quite narrow taxonomic groups. As the placenta and the maternal system associate more intimately, such that the conceptus relies extensively on maternal support, the relationship leads to

APA, Harvard, Vancouver, ISO und andere Zitierweisen

17

Gordon, Zoya, Osnat Eytan, Ariel J. Jaffa, and David Elad. "Hemodynamic analysis of Hyrtl anastomosis in human placenta." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 292, no. 2 (2007): R977—R982. http://dx.doi.org/10.1152/ajpregu.00410.2006.

Der volle Inhalt der Quelle

Annotation:

The Hyrtl anastomosis is a common connection between the umbilical arteries near the cord insertion in most human placentas. It has been speculated that it equalizes the blood pressure between the territories supplied by the umbilical arteries. However, its functional role in the regulation and distribution of fetal blood flow to the placenta has not yet been explored. A computational model has been developed for quantitative analysis of hemodynamic characteristic of the Hyrtl anastomosis in cases of discordant blood flow in the umbilical arteries. Simulations were performed for cases of eithe

APA, Harvard, Vancouver, ISO und andere Zitierweisen

18

Shearman, Lauren P., Alison M. McReynolds, Feng C. Zhou, and Jerrold S. Meyer. "Relationship between [125I]RTI-55-labeled cocaine binding sites and the serotonin transporter in rat placenta." American Journal of Physiology-Cell Physiology 275, no. 6 (1998): C1621—C1629. http://dx.doi.org/10.1152/ajpcell.1998.275.6.c1621.

Der volle Inhalt der Quelle

Annotation:

We investigated the characteristics of cocainelike binding sites in rat placenta using [125I]RTI-55. [3H]paroxetine binding and immunocytochemical staining for serotonin [5-hydroxytryptamine (5-HT)] and for the 5-HT transporter were also used to obtain evidence for rat placental 5-HT uptake. [125I]RTI-55 saturation analyses with membranes from normal gestational day 20 placentas yielded curvilinear Scatchard plots that were resolved into high- and low-affinity components (mean dissociation constants of 0.29 and 7.9 nM, respectively). Drug competition studies with various monoamine uptake inhib

APA, Harvard, Vancouver, ISO und andere Zitierweisen

19

Willis, D. M., J. P. O'Grady, J. J. Faber, and K. L. Thornburg. "Diffusion permeability of cyanocobalamin in human placenta." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 250, no. 3 (1986): R459—R464. http://dx.doi.org/10.1152/ajpregu.1986.250.3.r459.

Der volle Inhalt der Quelle

Annotation:

The molecular weight of cyanocobalamin is well suited to distinguish the two patterns of size discrimination found in the hemochorial and epitheliochorial placentas. The concentrations of cyanocobalamin that were used ensured that nondiffusional transport was negligible, and experiments on guinea pigs confirmed that the diffusion permeabilities measured with cyanocobalamin were the same as those expected for inert hydrophilic substances of similar molecular weight. All human studies were performed on volunteers who were scheduled for elective cesarean section under spinal or epidural anesthesi

APA, Harvard, Vancouver, ISO und andere Zitierweisen

20

Wilson, Rebecca L., Weston Troja, Emily K. Sumser, Alec Maupin, Kristin Lampe, and Helen N. Jones. "Insulin-like growth factor 1 signaling in the placenta requires endothelial nitric oxide synthase to support trophoblast function and normal fetal growth." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 320, no. 5 (2021): R653—R662. http://dx.doi.org/10.1152/ajpregu.00250.2020.

Der volle Inhalt der Quelle

Annotation:

Currently, there is no effective treatment for placental dysfunction in utero. In a ligated mouse model of fetal growth restriction (FGR), nanoparticle-mediated human insulin-like 1 growth factor ( hIGF1) gene delivery (NP-Plac1-hIGF1) increased hIGF1 expression and maintained fetal growth. However, whether it can restore fetal growth remains to be determined. Using the endothelial nitric oxide synthase knockout (eNOS−/−) mouse model, a genetic model of FGR, we found that despite inducing expression of hIGF1 in the placentas treated with NP-Plac1-hIGF1 ( P = 0.0425), FGR did not resolve. This

APA, Harvard, Vancouver, ISO und andere Zitierweisen

21

Gibbens, Jacob, Shauna-Kay Spencer, Lucia Solis, et al. "Fas ligand neutralization attenuates hypertension, endothelin-1, and placental inflammation in an animal model of HELLP syndrome." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 319, no. 2 (2020): R195—R202. http://dx.doi.org/10.1152/ajpregu.00272.2019.

Der volle Inhalt der Quelle

Annotation:

Neutralization of FasL is linked to suppression of hypertension, placental inflammation, and endothelin system activation in an animal model of hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. During HELLP syndrome the placenta has been reported to serve as the primary source of Fas ligand (FasL), which has an impact on inflammation and hypertension during pregnancy and is dysregulated in women with severe preeclampsia and HELLP syndrome. We hypothesize that neutralization of FasL during pregnancy in an animal model of HELLP syndrome decreases inflammation and placental apopt

APA, Harvard, Vancouver, ISO und andere Zitierweisen

22

Zhao, Fusheng, Fang Lei, Xiang Yan, Senfeng Zhang, Wen Wang, and Yu Zheng. "Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats." Cellular Physiology and Biochemistry 48, no. 5 (2018): 1815–28. http://dx.doi.org/10.1159/000492504.

Der volle Inhalt der Quelle

Annotation:

Background/Aims: Cigarette smoke exposure (CSE) during pregnancy is a well-recognized health hazard that causes placental damage. Hydrogen sulfide (H2S) has been reported to protect multiple organs from injury. However, the protective effects of H2S have not been tested in the placenta. This study aimed to explore the potential of H2S in protecting placenta against oxidative injury induced by CSE during pregnancy and the possible underlying mechanisms. Methods: Pregnant SD rats were randomly divided into 4 groups: NaCl, NaHS (a donor of H2S), CSE and CSE+NaHS. Placental oxidative damage was de

APA, Harvard, Vancouver, ISO und andere Zitierweisen

23

Van Dyke, James U., Matthew C. Brandley, and Michael B. Thompson. "The evolution of viviparity: molecular and genomic data from squamate reptiles advance understanding of live birth in amniotes." REPRODUCTION 147, no. 1 (2014): R15—R26. http://dx.doi.org/10.1530/rep-13-0309.

Der volle Inhalt der Quelle

Annotation:

Squamate reptiles (lizards and snakes) are an ideal model system for testing hypotheses regarding the evolution of viviparity (live birth) in amniote vertebrates. Viviparity has evolved over 100 times in squamates, resulting in major changes in reproductive physiology. At a minimum, all viviparous squamates exhibit placentae formed by the appositions of maternal and embryonic tissues, which are homologous in origin with the tissues that form the placenta in therian mammals. These placentae facilitate adhesion of the conceptus to the uterus as well as exchange of oxygen, carbon dioxide, water,

APA, Harvard, Vancouver, ISO und andere Zitierweisen

24

Hata, Toshiyuki, and Sarah Cajusay-Velasco. "Three-dimensional Power Doppler Ultrasound Study of the Placenta." Donald School Journal of Ultrasound in Obstetrics and Gynecology 8, no. 4 (2014): 400–409. http://dx.doi.org/10.5005/jp-journals-10009-1380.

Der volle Inhalt der Quelle

Annotation:

ABSTRACT Advanced ultrasound technology has been a valuable tool in the assessment of placental anatomy and physiology. Conventional two-dimensional (2D) sonography reveals placental morphological characteristics, 2D color Doppler can assess blood flow in the placenta, 2D power Doppler can evaluate placental vascular trees, and three-dimensional (3D) ultrasound gives more detailed information on the surface anatomy. Recent advances, such as 3D power Doppler with virtual organ computer aided-analysis (VOCAL) and histogram analysis can measure the placental volume, and assess uteroplacental and

APA, Harvard, Vancouver, ISO und andere Zitierweisen

25

Soliman, Natasha. "HOW IT WORKS 5: PHYSIOLOGICAL BIRTH OF THE PLACENTA." Practising Midwife 27, no. 02 (2024): 12–15. http://dx.doi.org/10.55975/nuap7898.

Der volle Inhalt der Quelle

Annotation:

In this article I talk about physiological birth of the placenta by exploring the anatomy and physiology of the placenta and its role in childbirth, pairing this with the skills required to facilitate a physiological placental birth. It is important for midwives to understand the anatomy and physiology behind the skill set required to provide care during physiological birth of the placenta and to understand how midwifery practice can influence achieving this for women and birthing people.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

26

Shahnawaz, Saira, Usman Shah Nawaz, Jonas Zaugg, et al. "Dysregulated Autophagy Leads to Oxidative Stress and Aberrant Expression of ABC Transporters in Women with Early Miscarriage." Antioxidants 10, no. 11 (2021): 1742. http://dx.doi.org/10.3390/antiox10111742.

Der volle Inhalt der Quelle

Annotation:

Early miscarriage (EMC) is a devastating obstetrical complication. ATP-binding cassette (ABC) transporters mediate cholesterol transfer across the placenta and enhance cell survival by effluxing substrates from target cells in the presence of stressors. Recent evidence reports an intricate interplay between autophagy and ABC transporters. We hypothesized that dysregulated autophagy and oxidative stress (OS) in the placenta leads to abnormal expression of membrane transporters contributing to poor pregnancy survival in EMC. We determined mRNA and protein expression of autophagy genes (Beclin-1/

APA, Harvard, Vancouver, ISO und andere Zitierweisen

27

Macias, Rocio I. R., Sonia Matilla, Elisa Lozano, Maria C. Estiú, Ronald P. Oude Elferink, and Jose J. G. Marin. "Role of the placenta in serum autotaxin elevation during maternal cholestasis." American Journal of Physiology-Gastrointestinal and Liver Physiology 315, no. 3 (2018): G399—G407. http://dx.doi.org/10.1152/ajpgi.00112.2018.

Der volle Inhalt der Quelle

Annotation:

Intrahepatic cholestasis of pregnancy (ICP) is frequently accompanied by pruritus, whose etiology has been associated with an enhanced production of lysophosphatidic acid (LPA) by the combined action of phospholipase A1/A2 (PLA1/PLA2) and autotaxin (ATX). Here, we have investigated whether the placenta is involved in LPA release to maternal circulation during ICP. Serum levels of ATX and LPA (determined by ELISA) were elevated in women with ICP, and a correlation between both parameters was found. No relationship between serum levels of ATX or LPA and bile acids was found. Expression levels of

APA, Harvard, Vancouver, ISO und andere Zitierweisen

28

Shaw, A. J., M. Z. Mughal, M. J. Maresh, and C. P. Sibley. "Sodium-dependent magnesium transport across in situ perfused rat placenta." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 261, no. 2 (1991): R369—R372. http://dx.doi.org/10.1152/ajpregu.1991.261.2.r369.

Der volle Inhalt der Quelle

Annotation:

Placentas of anesthetized rats were perfused in situ on the fetal side to study mechanisms of Mg2+ transport. The perfusate was a Mg(2+)-free Krebs-Ringer, and the unidirectional transfer of Mg2+ from maternal plasma to this Ringer was compared with that of 45Ca and 51Cr-EDTA, the latter being employed as a paracellular diffusional marker. Placental perfusion with amiloride (0.5 mM) or ouabain (1 mM) both rapidly (4 min) reduced maternal-fetal clearance (Kmf) for Mg2+ but had no effect on Kmf for 45Ca. In contrast, perfusion of the carbonic anhydrase inhibitor acetazolamide (1 mM) did not affe

APA, Harvard, Vancouver, ISO und andere Zitierweisen

29

Mark, P. J., J. L. Lewis, M. L. Jones, and B. J. Waddell. "158. THE UNFOLDED PROTEIN RESPONSE MAY CONTRIBUTE TO GLUCOCORTICOID-INDUCED PLACENTAL GROWTH RESTRICTION IN THE RAT VIA INCREASED PLACENTAL EXPRESSION OF HEAT SHOCK PROTEIN 70." Reproduction, Fertility and Development 22, no. 9 (2010): 76. http://dx.doi.org/10.1071/srb10abs158.

Der volle Inhalt der Quelle

Annotation:

Perturbations of normal endoplasmic reticulum (ER) physiology occur in a number of pathological conditions, including diabetes and preeclampsia. These pathologies are associated with elevated levels of inappropriately folded proteins and induction of ER stress. Accumulation of misfolded proteins induces the unfolded protein response which increases ER protein folding capacity and promotes ER-associated degradation of unfolded proteins. Glucocorticoids are essential for maturation of fetal organs, however excess exposure during pregnancy retards fetal and placental growth. Glucocorticoids also

APA, Harvard, Vancouver, ISO und andere Zitierweisen

30

Yang, Xiaotao, Ping Xu, Fumei Zhang, et al. "AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia." Cellular Physiology and Biochemistry 49, no. 2 (2018): 578–94. http://dx.doi.org/10.1159/000492995.

Der volle Inhalt der Quelle

Annotation:

Background/Aims: Preeclampsia (PE) has long been assumed to be an ischemic disease of the placenta, although there is limited evidence as to how the ischemia impacts on the placenta. AMP-activated protein kinase (AMPK) is a key regulator of cellular energy metabolism and plays an important role in a variety of ischemic diseases by enhancing energy production. The present study investigated placental metabolism in PE, and the role of AMPK in regulating trophoblast function. Methods: placentas from normal and PE complicated pregnancies were subjected to GC-MS to identify fatty acids (FA) metabol

APA, Harvard, Vancouver, ISO und andere Zitierweisen

31

Mandò, Chiara, Valeria M. Savasi, Gaia M. Anelli, et al. "Mitochondrial and Oxidative Unbalance in Placentas from Mothers with SARS-CoV-2 Infection." Antioxidants 10, no. 10 (2021): 1517. http://dx.doi.org/10.3390/antiox10101517.

Der volle Inhalt der Quelle

Annotation:

SARS-CoV-2 infection has been related to adverse pregnancy outcomes. A placental role in protecting the fetus from SARS-CoV-2 infection has been documented. Nevertheless, it is still unclear how the placenta is affected in SARS-CoV-2 infection. Here we assessed placental mitochondrial (mt) and oxidative features in COVID-19 and healthy mothers. mtDNA levels, DNA oxidative damage, expression levels of genes involved in antioxidant defenses, mitochondrial dynamics and respiratory chain subunits were investigated in placentas from singleton pregnancies of 30 women with SARS-CoV-2 infection during

APA, Harvard, Vancouver, ISO und andere Zitierweisen

32

Borke, James L., Ariel Caride, Anil K. Verma, et al. "Calcium pump epitopes in placental trophoblast basal plasma membranes." American Journal of Physiology-Cell Physiology 257, no. 2 (1989): C341—C346. http://dx.doi.org/10.1152/ajpcell.1989.257.2.c341.

Der volle Inhalt der Quelle

Annotation:

The syncytiotrophoblast represents the primary cellular barrier between maternal and fetal circulations in the placenta. Large amounts of Ca2+ are transported across this barrier by mechanisms that are not clearly understood. To further understand this phenomenon, we examined rat and human placenta by immunohistochemical and protein blotting techniques with a monoclonal antibody raised against the human erythrocyte plasma membrane Ca2+ pump. Immunohistochemistry with this antibody showed specific staining in the human placenta of the basal (fetal facing) surface of the syncytiotrophoblast. In

APA, Harvard, Vancouver, ISO und andere Zitierweisen

33

Barreto, Rodrigo da Silva Nunes, Ana Claudia Oliveira Carreira, Mônica Duarte da Silva, et al. "Mice Placental ECM Components May Provide A Three-Dimensional Placental Microenvironment." Bioengineering 10, no. 1 (2022): 16. http://dx.doi.org/10.3390/bioengineering10010016.

Der volle Inhalt der Quelle

Annotation:

Bioethical limitations impair deeper studies in human placental physiology, then most studies use human term placentas or murine models. To overcome these challenges, new models have been proposed to mimetize the placental three-dimensional microenvironment. The placental extracellular matrix plays an essential role in several processes, being a part of the establishment of materno-fetal interaction. Regarding these aspects, this study aimed to investigate term mice placental ECM components, highlighting its collagenous and non-collagenous content, and proposing a potential three-dimensional m

APA, Harvard, Vancouver, ISO und andere Zitierweisen

34

Bainbridge, Shannon A., and Graeme N. Smith. "The effect of nicotine on in vitro placental perfusion pressure." Canadian Journal of Physiology and Pharmacology 84, no. 8-9 (2006): 953–57. http://dx.doi.org/10.1139/y06-037.

Der volle Inhalt der Quelle

Annotation:

Cigarette smoking throughout pregnancy is associated with several negative outcomes, of which an increased incidence of intra-uterine growth restriction (IUGR) is most pronounced. Gestationally age-matched infants born to smoking mothers are, on average, 200 g lighter at birth, per pack smoked per day. The mechanisms and specific tobacco compounds responsible for the increased risk of IUGR among smokers have yet to be identified; however, it is widely accepted that smoking women have compromised placental perfusion throughout gestation due to the vasoconstricting effect of nicotine on uterine

APA, Harvard, Vancouver, ISO und andere Zitierweisen

35

Magnusson-Olsson, Anne Liese, Susanne Lager, Bo Jacobsson, Thomas Jansson, and Theresa L. Powell. "Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency." American Journal of Physiology-Endocrinology and Metabolism 293, no. 1 (2007): E24—E30. http://dx.doi.org/10.1152/ajpendo.00571.2006.

Der volle Inhalt der Quelle

Annotation:

Maternal hypertriglyceridemia is a normal condition in late gestation and is an adaptation to ensure an adequate nutrient supply to the fetus. Placental lipoprotein lipase (LPL) is involved in the initial step in transplacental fatty acid transport as it hydrolyzes maternal triglycerides (TG) to release free fatty acids (FFA). We investigated LPL activity and protein (Western blot) and mRNA expression (real-time RT-PCR) in the placenta of an LPL-deficient mother with marked hypertriglyceridemia. The LPL activity was fourfold lower, LPL protein expression 50% lower, and mRNA expression threefol

APA, Harvard, Vancouver, ISO und andere Zitierweisen

36

Castillo-Castrejon, Marisol, Thomas Jansson, and Theresa L. Powell. "No evidence of attenuation of placental insulin-stimulated Akt phosphorylation and amino acid transport in maternal obesity and gestational diabetes mellitus." American Journal of Physiology-Endocrinology and Metabolism 317, no. 6 (2019): E1037—E1049. http://dx.doi.org/10.1152/ajpendo.00196.2019.

Der volle Inhalt der Quelle

Annotation:

Pregnancies complicated by obesity and/or gestational diabetes (GDM) are associated with peripheral insulin resistance; however, the insulin responsiveness of the placenta in these pregnancy complications remains largely unknown. We tested the hypothesis that primary human trophoblast cells and placental villous explants will be insulin responsive, characterized by amino acid transport, Akt and Erk activity with maternal obesity, and/or GDM. We evaluated term placentas from women with normal body mass index (BMI) (normal; n = 15), obesity (OB; n = 11), normal BMI with GDM (N-GDM; n = 11), and

APA, Harvard, Vancouver, ISO und andere Zitierweisen

37

Kilpatrick, S. J., J. M. Roberts, D. L. Lykins, and R. N. Taylor. "Characterization and ontogeny of endothelin receptors in human placenta." American Journal of Physiology-Endocrinology and Metabolism 264, no. 3 (1993): E367—E372. http://dx.doi.org/10.1152/ajpendo.1993.264.3.e367.

Der volle Inhalt der Quelle

Annotation:

Because of the potent mitogenic and vasoactive properties of endothelin-1 (ET-1) and the presence of its receptor in third trimester placenta, we postulated that ET-1 might be involved in human placental growth and vascularization during development. As an initial approach to test this hypothesis, placental ET receptors were characterized and quantified in each trimester of pregnancy. Membrane-rich particulates were prepared from first-, second-, and third-trimester villous human placenta obtained immediately after pregnancy termination or delivery. ET receptors were characterized by radioliga

APA, Harvard, Vancouver, ISO und andere Zitierweisen

38

Greupink, Rick. "1 Placental pharmacology studies to characterize the effects and disposition of pharmaceuticals: lessons from human tissues and cells for improving drug safety in pregnancy." Archives of Disease in Childhood 108, no. 6 (2023): A1.1—A1. http://dx.doi.org/10.1136/archdischild-2023-esdppp.1.

Der volle Inhalt der Quelle

Annotation:

The placenta plays a key role in maintaining a healthy pregnancy. In order to improve drug safety during pregnancy, it is therefore relevant to understand to which extent and at which rate drugs are transferred across the placenta and how pharmaceuticals may affect placental function. Translational and predictive pharmacology studies based on human tissues and cells are becoming increasingly important in characterizing the effects and disposition of pharmaceuticals. With regard to the placenta, such approaches may for example be readily combined with physiology-based pharmacokinetic (PBPK) mod

APA, Harvard, Vancouver, ISO und andere Zitierweisen

39

Elzinga, Femke A., Behrad Khalili, Daan J. Touw, et al. "Placenta-on-a-Chip as an In Vitro Approach to Evaluate the Physiological and Structural Characteristics of the Human Placental Barrier upon Drug Exposure: A Systematic Review." Journal of Clinical Medicine 12, no. 13 (2023): 4315. http://dx.doi.org/10.3390/jcm12134315.

Der volle Inhalt der Quelle

Annotation:

Quantification of fetal drug exposure remains challenging since sampling from the placenta or fetus during pregnancy is too invasive. Currently existing in vivo (e.g., cord blood sampling) and ex vivo (e.g., placenta perfusion) models have inherent limitations. A placenta-on-a-chip model is a promising alternative. A systematic search was performed in PubMed on 2 February 2023, and Embase on 14 March 2023. Studies were included where placenta-on-a-chip was used to investigate placental physiology, placenta in different obstetric conditions, and/or fetal exposure to maternally administered drug

APA, Harvard, Vancouver, ISO und andere Zitierweisen

40

John, Rosalind M. "Epigenetic regulation of placental endocrine lineages and complications of pregnancy." Biochemical Society Transactions 41, no. 3 (2013): 701–9. http://dx.doi.org/10.1042/bst20130002.

Der volle Inhalt der Quelle

Annotation:

A defining feature of mammals is the development in utero of the fetus supported by the constant flow of nutrients from the mother obtained via a specialized organ: the placenta. The placenta is also a major endocrine organ that synthesizes vast quantities of hormones and cytokines to instruct both maternal and fetal physiology. Nearly 20 years ago, David Haig and colleagues proposed that placental hormones were likely targets of the epigenetic process of genomic imprinting in response to the genetic conflicts imposed by in utero development [Haig (1993) Q. Rev. Biol. 68, 495–532]. There are t

APA, Harvard, Vancouver, ISO und andere Zitierweisen

41

Watson, Erica D., and James C. Cross. "Development of Structures and Transport Functions in the Mouse Placenta." Physiology 20, no. 3 (2005): 180–93. http://dx.doi.org/10.1152/physiol.00001.2005.

Der volle Inhalt der Quelle

Annotation:

The placenta is essential for sustaining the growth of the fetus during gestation, and defects in its function result in fetal growth restriction or, if more severe, fetal death. Several molecular pathways have been identified that are essential for development of the placenta, and mouse mutants offer new insights into the cell biology of placental development and physiology of nutrient transport.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

42

Paterson, P. G., B. Sarkar, and S. H. Zlotkin. "The effect of zinc levels in fetal circulation on zinc clearance across the in situ perfused guinea pig placenta." Canadian Journal of Physiology and Pharmacology 68, no. 11 (1990): 1401–6. http://dx.doi.org/10.1139/y90-213.

Der volle Inhalt der Quelle

Annotation:

Although zinc is essential for normal fetal growth and development, little is known about factors that influence its transfer across the placenta. The in situ perfused guinea pig placenta model was used to study the influence of the zinc concentration of fetal circulation on maternofetal placental zinc transfer. A placenta of the anaesthetized sow was perfused (on the fetal side) with a physiological perfusate via the umbilical vessels, with the fetus excluded. The sow was infused intravenously with 65zinc as a tracer of placental Zn clearance, and with antipyrine as an indirect indicator of m

APA, Harvard, Vancouver, ISO und andere Zitierweisen

43

Lazo-de-la-Vega-Monroy, Maria-Luisa, Karen-Alejandra Mata-Tapia, Juan-Antonio Garcia-Santillan, et al. "Association of placental nutrient sensing pathways with birth weight." Reproduction 160, no. 3 (2020): 455–68. http://dx.doi.org/10.1530/rep-20-0186.

Der volle Inhalt der Quelle

Annotation:

Birth weight (BW) is an important indicator for newborn health. Both high and low BW is associated with increased risks for adult metabolic diseases. AMPK (AMP-activated protein kinase), mTOR (mechanistic target of rapamycin), and insulin/IGF1 (insulin-like growth factor 1) pathways may function as placental sensors of maternal hormonal and nutritional status. However, the physiological role of these pathways in placenta has not been completely elucidated. To evaluate expression and activation of AMPK, mTOR, and insulin/IGF1 pathways and its association with placental weight (PW), BW, and mate

APA, Harvard, Vancouver, ISO und andere Zitierweisen

44

Zhang, Xue Mei, Xi Xiong, Chao Tong та ін. "Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway". Cellular Physiology and Biochemistry 51, № 5 (2018): 2030–40. http://dx.doi.org/10.1159/000495822.

Der volle Inhalt der Quelle

Annotation:

Background/Aims: Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion. Methods: LN-α5 expression levels were examined by reverse-transcriptase polymerase chain reaction (RT-PCR), and further confirmed by western blotting and immunofluorescence st

APA, Harvard, Vancouver, ISO und andere Zitierweisen

45

Visiedo, Francisco, Fernando Bugatto, Viviana Sánchez, Irene Cózar-Castellano, Jose L. Bartha, and Germán Perdomo. "High glucose levels reduce fatty acid oxidation and increase triglyceride accumulation in human placenta." American Journal of Physiology-Endocrinology and Metabolism 305, no. 2 (2013): E205—E212. http://dx.doi.org/10.1152/ajpendo.00032.2013.

Der volle Inhalt der Quelle

Annotation:

Placentas of women with gestational diabetes mellitus (GDM) exhibit an altered lipid metabolism. The mechanism by which GDM is linked to alterations in placental lipid metabolism remains obscure. We hypothesized that high glucose levels reduce mitochondrial fatty acid oxidation (FAO) and increase triglyceride accumulation in human placenta. To test this hypothesis, we measured FAO, fatty acid esterification, de novo fatty acid synthesis, triglyceride levels, and carnitine palmitoyltransferase activities (CPT) in placental explants of women with GDM or no pregnancy complication. In women with G

APA, Harvard, Vancouver, ISO und andere Zitierweisen

46

Ali, Asghar, Frieder Hadlich, Muhammad W. Abbas, et al. "MicroRNA–mRNA Networks in Pregnancy Complications: A Comprehensive Downstream Analysis of Potential Biomarkers." International Journal of Molecular Sciences 22, no. 5 (2021): 2313. http://dx.doi.org/10.3390/ijms22052313.

Der volle Inhalt der Quelle

Annotation:

Pregnancy complications are a major cause of fetal and maternal morbidity and mortality in humans. The majority of pregnancy complications initiate due to abnormal placental development and function. During the last decade, the role of microRNAs (miRNAs) in regulating placental and fetal development has become evident. Dysregulation of miRNAs in the placenta not only affects placental development and function, but these miRNAs can also be exported to both maternal and fetal compartments and affect maternal physiology and fetal growth and development. Due to their differential expression in the

APA, Harvard, Vancouver, ISO und andere Zitierweisen

47

Schäffer, Leonhard, Johannes Vogel, Christian Breymann, Max Gassmann, and Hugo H. Marti. "Preserved placental oxygenation and development during severe systemic hypoxia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 290, no. 3 (2006): R844—R851. http://dx.doi.org/10.1152/ajpregu.00237.2005.

Der volle Inhalt der Quelle

Annotation:

Local tissue oxygenation profoundly influences placental development. To elucidate the impact of hypoxia on cellular and molecular adaptation in vivo, pregnant mice at embryonic days 7.5–11.5 were exposed to reduced environmental oxygen (6–7% O2) for various periods of time. Hypoxia-inducible factor (HIF)-1α mRNA was highly expressed in the placenta, whereas HIF-2α was predominantly found in the decidua, indicating that HIF-1 is a relevant oxygen-dependent factor involved in placental development. During severe hypoxia, HIF-1α protein was strongly induced in the periphery but, however, not in

APA, Harvard, Vancouver, ISO und andere Zitierweisen

48

Jin, Yan, Hana Vakili, Song Yan Liu, Savas Menticoglou, Margaret E. Bock, and Peter A. Cattini. "Chromosomal architecture and placental expression of the human growth hormone gene family are targeted by pre-pregnancy maternal obesity." American Journal of Physiology-Endocrinology and Metabolism 315, no. 4 (2018): E435—E445. http://dx.doi.org/10.1152/ajpendo.00042.2018.

Der volle Inhalt der Quelle

Annotation:

The human (h) placental lactogenic hormone chorionic somatomammotropin (CS) is highly produced during pregnancy and acts as a metabolic adaptor in response to maternal insulin resistance. Maternal obesity can exacerbate this “resistance”, and a >75% decrease in CS RNA levels was observed in term placentas from obese vs. lean women. The genes coding for hCS ( hCS-A and hCS-B) and placental growth hormone ( hGH-V) as well as the hCS-L pseudogene and pituitary growth hormone (GH) gene ( hGH-N) are located at a single locus on chromosome 17. Three remote hypersensitive sites (HS III–V) located

APA, Harvard, Vancouver, ISO und andere Zitierweisen

49

Waddell, B. J. "056. EUTHERIAN MAMMALS DO IT DIFFERENTLY: PLACENTAL ENDOCRINE STRATEGIES FOR THE MAINTENANCE OF PREGNANCY IN RODENTS AND PRIMATES." Reproduction, Fertility and Development 22, no. 9 (2010): 17. http://dx.doi.org/10.1071/srb10abs056.

Der volle Inhalt der Quelle

Annotation:

The placenta of rats and humans share important anatomical similarities, each with a chorio-allantoic, single discoid, haemochorial structure that facilitates highly efficient nutrient transport. Importantly, however, these similarities reflect convergent evolution and conceal markedly different developmental trajectories and endocrine functions. Placental endocrine signals are essential to drive maternal adaptations that facilitate fetal development and ultimately successful birth. Central to these adaptations is a sustained increase in production of the sex steroids progesterone and oestroge

APA, Harvard, Vancouver, ISO und andere Zitierweisen

50

Wieser, Fritz, Leslie Waite, Christophe Depoix, and Robert N. Taylor. "PPAR Action in Human Placental Development and Pregnancy and Its Complications." PPAR Research 2008 (2008): 1–14. http://dx.doi.org/10.1155/2008/527048.

Der volle Inhalt der Quelle

Annotation:

During pregnancy crucial anatomic, physiologic, and metabolic changes challenge the mother and the fetus. The placenta is a remarkable organ that allows the mother and the fetus to adapt to the new metabolic, immunologic, and angiogenic environment imposed by gestation. One of the physiologic systems that appears to have evolved to sustain this metabolic regulation is mediated by peroxisome proliferator-activated receptors (PPARs). In clinical pregnancy-specific disorders, including preeclampsia, gestational diabetes, and intrauterine growth restriction, aberrant regulation of components of th

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Wir bieten Rabatte auf alle Premium-Pläne für Autoren, deren Werke in thematische Literatursammlungen aufgenommen wurden. Kontaktieren Sie uns, um einen einzigartigen Promo-Code zu erhalten!