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Zeitschriftenartikel zum Thema „Prb6“

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Veröffentlicht am 8. November 2023

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1

Anisimov, M. A., A. V. Bogach, V. V. Glushkov, S. V. Demishev, N. A. Samarin, N. Y. Shitsevalova, A. V. Levchenko, V. B. Filipov, A. V. Kuznetsov und N. E. Sluchanko. „Suppression of Spin-Glass State in PrB₆“. Solid State Phenomena 190 (Juni 2012): 221–24. http://dx.doi.org/10.4028/www.scientific.net/ssp.190.221.

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The comprehensive study of transverse magnetoresistance (MR) and magnetization has been carried out on the high quality single crystals of PrB6 in the wide range of temperatures 2-40K and magnetic fields up to 80kOe. In order to estimate the role of boron vacancies in the formation of the new spin-glass (SG) phase detected by Alekseev et al. below 20K the experiments were carried out on the ordinary (initial state) and annealed single crystals of PrB6. The data obtained demonstrate the appearance of spontaneous magnetization below TSG21.3K with M~1.6 emu/mol for initial state and the absence of spontaneous magnetization for the annealed PrB6 samples. On the contrary, quite similar behavior of MR was detected for various samples of PrB6. Our results suggest the existence of the aggregated boron vacancies which provoke the new SG phase formation in PrB6 at TSG.

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2

Lyons, K. M., J. H. Stein und O. Smithies. „Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.“ Genetics 120, Nr. 1 (01.09.1988): 267–78. http://dx.doi.org/10.1093/genetics/120.1.267.

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Abstract Southern blot hybridization analysis of genomic DNAs from 44 unrelated individuals revealed extensive insertion/deletion polymorphisms within the BstNI-type loci (PRB1, PRB2, PRB3 and PRB4) of the human proline-rich protein (PRP) multigene family. Ten length variants were cloned, including alleles at each of the four PRB loci, and in every case the region of length difference was localized to the tandemly repetitious third exon. DNA sequences covering the region of length variation were determined for seven of the alleles. The data indicate (1) that the PRB loci can be divided into two subtypes, PRB1 plus PRB2, and PRB3 plus PRB4, and (2) that the length differences result from different numbers of tandem repeats in the third exons. Variant chromosomes were also identified with different numbers of PRP loci resulting from homologous but unequal exchange between the PRB1 and PRB2 loci. The overall data are compatible with the observed length variants having been generated via homologous but unequal intragenic exchange. The results also indicate that these crossover events are sensitive to the amount of homology shared between the interacting DNA strands. Allelic length variants have arisen independently at least 20 times at the PRB loci, but only one has been detected at a PRH locus. Comparison of the detailed structures of the repetitious regions in PRB and PRH loci shows that the repeats in PRB genes are very similar to each other in sequence and in length. The PRH genes contain fewer repeats, which differ considerably in their individual lengths. These differences suggest that the larger number of length variants in PRB genes is related to their greater ease of homologous but unequal pairing compared to PRH genes.

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3

Kuromaru, Tomoya, Hiroaki Kusunose und Yoshio Kuramoto. „Multipolar Ordering in PrB6“. Journal of the Physical Society of Japan 71, Suppl (Januar 2002): 130–32. http://dx.doi.org/10.1143/jpsjs.71s.130.

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4

Xu, Junqi, Yanrui Wang, Wenjie Wang, Zijun Xu, Yonglei Jia, Yandi Zhang, Minghui Huang, Lubin Wang, Fengyuan Liu und Wenhe Xie. „Growth of Large-Scale Praseodymium Hexaborides (PrB6) Nanowires and Enhanced Field-Emission Performance“. Journal of Nanoelectronics and Optoelectronics 15, Nr. 2 (01.02.2020): 276–83. http://dx.doi.org/10.1166/jno.2020.2722.

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Large-scale PrB6 nanowires were fabricated by an effective, catalyst-free, and a simple low-pressure chemical vapor deposition (LPCVD) process. These nanowires, characterized in detail by various analytical instruments, demonstrated the large aspect ratio and high single-crystalline grown along the [001] crystal direction perpendicular to the (001) crystal plane. The field electron emission equipment tests manifest that the asgrown PrB6 products have a low turn-on field (Eto, 2.32 V/μm), a threshold field (Ethr, 4.28 V/μm), a high field enhancement factor (β, 2336), as well as a stable current-density (J) of field-emission. The relationships of the field electron emission parameters, such as J, Eto, and β versus cathode gap (d), have been established when d is increased from 500 μm to 800 μm. The outstanding properties suggest that the PrB6 products may be promising emitters in the cold-field-emission cathode application.

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5

Sera, Masafumi, Satoru Kunii und Tadao Kasuya. „Oscillatory Magnetostrictions of LaB6and PrB6“. Journal of the Physical Society of Japan 57, Nr. 1 (15.01.1988): 13–15. http://dx.doi.org/10.1143/jpsj.57.13.

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6

Loewenhaupt, M., und M. Prager. „Crystal fields in PrB6 and NdB6“. Zeitschrift f�r Physik B Condensed Matter 62, Nr. 2 (Juni 1986): 195–99. http://dx.doi.org/10.1007/bf01323430.

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7

Лазуков, В. Н., П. А. Алексеев, Н. Ю. Шицевалова und В. Б. Филиппов. „Температурная эволюция спектра магнитных возбуждений PrB6“. Физика металлов и металловедение 117, Nr. 5 (2016): 478–84. http://dx.doi.org/10.7868/s0015323016050132.

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8

Ōnuki, Y., M. Nishihara, M. Sato und T. Komatsubara. „Fermi surface and cyclotron mass of PrB6“. Journal of Magnetism and Magnetic Materials 52, Nr. 1-4 (Oktober 1985): 317–19. http://dx.doi.org/10.1016/0304-8853(85)90290-2.

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9

Lazukov, V. N., P. A. Alekseev, N. Yu Shitsevalova und V. B. Philippov. „Thermal evolution of magnetic-excitation spectrum of PrB6“. Physics of Metals and Metallography 117, Nr. 5 (Mai 2016): 460–65. http://dx.doi.org/10.1134/s0031918x16050136.

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10

Kasuya, Tadao, und Hisatomo Harima. „Puzzle on the Fermi Surface in CeB6and PrB6“. Journal of the Physical Society of Japan 65, Nr. 7 (15.07.1996): 1898–901. http://dx.doi.org/10.1143/jpsj.65.1898.

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11

Nefeodova, E. V., N. N. Tiden, K. Siemensmeyer, P. A. Alekseev, V. N. Lazukov, I. P. Sadikov und N. Yu Shitsevalova. „Neutron studies of crystal-field effects in PrB6“. Journal of Experimental and Theoretical Physics 105, Nr. 1 (Juli 2007): 12–13. http://dx.doi.org/10.1134/s1063776107070035.

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12

Takagi, S., S. Itabashi, S. Kunii und T. Kasuya. „11B nuclear relaxation studies of PrB6 and NdB6“. Journal of Magnetism and Magnetic Materials 52, Nr. 1-4 (Oktober 1985): 267–70. http://dx.doi.org/10.1016/0304-8853(85)90276-8.

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13

Priputen, P., M. Reiffers, S. Gabáni, K. Flachbart, E. Šantavá, J. Šebek, P. A. Alekseev, E. V. Nefeodova, I. P. Sadikov und N. Shitsevalova. „Magnetic Field Influence on the Thermal Conductivity of PrB6“. Acta Physica Polonica A 113, Nr. 1 (Januar 2008): 383–86. http://dx.doi.org/10.12693/aphyspola.113.383.

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14

Lazukov, V. N., E. V. Nefeodova, N. N. Tiden, K. Siemensmeyer, A. Buchsteiner, P. A. Alekseev und N. Yu Shitsevalova. „Temperature evolution of Pr-ion magnetic response in PrB6“. Journal of Alloys and Compounds 442, Nr. 1-2 (September 2007): 180–82. http://dx.doi.org/10.1016/j.jallcom.2006.06.112.

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15

Wei, Wei, Bao Lihong, Li Yingjie, Chao Luomeng und O. Tegus. „Solid-state reaction synthesis and characterization of PrB6 nanocrystals“. Journal of Crystal Growth 415 (April 2015): 123–26. http://dx.doi.org/10.1016/j.jcrysgro.2014.12.030.

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16

Tamaki, A., T. Goto, M. Yoshizawa, T. Fujimura, S. Kunii und T. Kasuya. „Elastic softening and CEF effects of NdB6 and PrB6“. Journal of Magnetism and Magnetic Materials 52, Nr. 1-4 (Oktober 1985): 257–60. http://dx.doi.org/10.1016/0304-8853(85)90273-2.

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17

Galéra, R. M., P. Morin, S. Kunii und T. Kasuya. „Magnetic properties and phase diagrams in PrB6 and GdB6“. Journal of Magnetism and Magnetic Materials 104-107 (Februar 1992): 1336–38. http://dx.doi.org/10.1016/0304-8853(92)90608-q.

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18

Morin, P., S. Kunii und T. Kasuya. „Quadrupolar properties and magnetic phase diagrams in PrB6 hexaboride compound“. Journal of Magnetism and Magnetic Materials 96, Nr. 1-3 (Juni 1991): 145–54. http://dx.doi.org/10.1016/0304-8853(91)90622-h.

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19

Anisimov, M. A., V. V. Glushkov, S. V. Demishev, N. A. Samarin, N. Y. Shitsevalova und N. E. Sluchanko. „High Field Magnetoresistance Behavior in PrB₆ and NdB₆“. Solid State Phenomena 152-153 (April 2009): 541–44. http://dx.doi.org/10.4028/www.scientific.net/ssp.152-153.541.

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The comprehensive study of low temperature magnetoresistance (MR) has been carried out on high quality PrB6 and NdB6 single crystals at temperatures 2–20K and in magnetic fields up to 8T. The negative MR (Δρ/ρ<0) was found in the paramagnetic state at T>TN for both compounds. The analysis of the experimental data allows us to establish three contributions to MR. In addition to the main Brillouin type negative component –Δρ/ρ~Mloc2~H2 which may be interpreted in terms of Yosida theory [Phys. Rev. 107 (1957) 396] both the linear and nonlinear magnetic contributions were also deduced. According to detailed analysis in the framework of spin–polaron approach proposed by A.V. Bogach et al. [Physica B 378–380 (1957) 769] the last component should be ascribed to the ferromagnetic (FM) nanodomains embedded in the metallic RB6 matrix. The estimation of local magnetic susceptibility χloc=(–1/H•(d(Δρ/ρ)/dH))1/2 is deduced directly from the quadratic part of negative MR and reveals Curie–Weiss type behaviour in paramagnetic (PM) phase with paramagnetic Curie temperatures Θp~– 22K and –31K for PrB6 and NdB6 correspondingly. The results of undertaken analysis allow to conclude in favour of the concurrence between AF and FM iteractions as the main reason of incommensurate (IC) magnetic structure formation in RB6.

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20

Fedyshyn, Y., D. Vadets, O. Garashchenko, O. Romanov und T. Fedyshyn. „The estimation of the parameter Gruneisen metal hexaborides“. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, Nr. 90 (13.11.2018): 36–39. http://dx.doi.org/10.32718/nvlvet9008.

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The basis for the estimation of the Gruneisen parameter γ is laid (θД – Debye’s characteristic temperature, V– molar volume) from which the mathematical expression follows . In previous publications in order to determine θД the Lindemann formula was used. However, due to the ambiguity of the dimensional coefficient C in the Lindemann formula, the authors used the method of high-temperature roentgenography within the limits of 293–973 K. On the basis of analisys of the intensity of one maximum interference (hkl) at different temperatures, was determined by Chipman’s method X-ray characteristic temperature θр(Т) groups of hexaboard type CaB6, namely CaB6, YB6, LaB6, CeB6, PrB6 , NdB6, ErB6, ThB6, YbB6. Considering, that neither the structure nor the interatomic connections within the temperature search of hexaborides does not change, the value of the parameter γ is determined. Its value was obtained within 2.5–4.7 for CeB6, NdB6, ErB6, YbB6, ThB6 and order 5.5–6.6 for CaB6, YB6, LaB6, PrB6. The parameters of Gruneisen proved to be practically independent of temperature. The presence of the meanings of γ made it possible to divide the implicit and explicit parts of the anagrammonism into a calming measure. The generalizing measure of anharmonism is mainly exhausted by the product γβ (β – the coefficient of the volumetric expansion of the crystalline lattice.

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21

Lyons, K. M., E. A. Azen, P. A. Goodman und O. Smithies. „Many protein products from a few loci: assignment of human salivary proline-rich proteins to specific loci.“ Genetics 120, Nr. 1 (01.09.1988): 255–65. http://dx.doi.org/10.1093/genetics/120.1.255.

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Abstract Earlier studies of protein polymorphisms led to the description of 13 linked loci thought to encode the human salivary proline-rich proteins (PRPs). However, more recent studies at the DNA level have shown that there are only six genes which encode PRPs. The present study was undertaken in order to reconcile these observations. Nucleotide and decoded amino acid sequences from each of the six genes were compared with the available protein sequence data for PRPs. This analysis allowed assignment of the PmF, PmS and Pe proteins to the PRB1 locus, the G1 protein to the PRB3 locus, the Po protein to the PRB4 locus, the Ps protein to the PRB2 locus, and the CON1 and CON2 proteins to the PRB4 locus. Correlations between insertion/deletion RFLPs and PRP protein phenotypes were observed for the PmF, PmS, Gl and CON2 proteins. Our overall analysis indicates that in many instances several proteins previously considered to be the products of separate loci are actually proteolytic cleavage products of a large precursor specified by one or other of the six genes identified at the DNA level. Our analysis also demonstrates that some of the "null" alleles proposed to occur at 11 of the 13 loci in the earlier genetic studies, are actually productive alleles having alterations at proteolytic cleavage sites within the relevant precursor protein. The absence of cleavage leads to the persistence of longer precursor peptides not resolved electrophoretically, concurrently with an absence of the smaller PRPs seen when cleavage occurs.

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22

Alekseev, P. A., K. Flachbart, S. Gabani, V. N. Lazukov, P. Priputen, M. Reiffers, J. Sebek et al. „Specific features of the formation of the ground state in PrB6“. Physics of the Solid State 52, Nr. 5 (Mai 2010): 914–16. http://dx.doi.org/10.1134/s1063783410050069.

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23

Yamamoto, N., E. Rokuta, Y. Hasegawa, T. Nagao, M. Trenary, C. Oshima und S. Otani. „Oxygen adsorption sites on the PrB6(100) and LaB6(100) surfaces“. Surface Science 348, Nr. 1-2 (März 1996): 133–42. http://dx.doi.org/10.1016/0039-6028(95)00989-2.

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24

Chi, Mingfeng, Yanming Zhao, Qinghua Fan und Wei Han. „The synthesis of PrB6 nanowires and nanotubes by the self-catalyzed method“. Ceramics International 40, Nr. 6 (Juli 2014): 8921–24. http://dx.doi.org/10.1016/j.ceramint.2014.01.046.

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25

Sera, Masafumi, Moo-Sung Kim, Hideki Tou und Satoru Kunii. „Crystal Structure and Magnetic Anisotropy in the Magnetic Ordered Phases of PrB6“. Journal of the Physical Society of Japan 73, Nr. 12 (15.12.2004): 3422–28. http://dx.doi.org/10.1143/jpsj.73.3422.

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26

Otani, Shigeki, Takaho Tanaka und Yoshio Ishizawa. „Effect of PrB6 addition to LaB6 crystals grown by the floating zone method“. Journal of Crystal Growth 113, Nr. 1-2 (August 1991): 329–32. http://dx.doi.org/10.1016/0022-0248(91)90037-6.

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27

Sera, Masafumi, Shinya Goto, Tatsurou Koshikawa, Moo-Sung Kim, Hideki Tou, Fumitoshi Iga, Yutaka Mitsukawa und Kenichi Kojima. „Rapid Suppression of the Commensurate Magnetic Ordered Phase of PrB6 by La Doping“. Journal of the Physical Society of Japan 74, Nr. 10 (Oktober 2005): 2691–94. http://dx.doi.org/10.1143/jpsj.74.2691.

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28

Muratov, V. B., A. S. Bolgar, P. I. Loboda und V. V. Morozov. „Enthalpy and heat capacity of CeB6, PrB6, and EuB6 in a wide temperature range“. Soviet Powder Metallurgy and Metal Ceramics 27, Nr. 12 (Dezember 1988): 984–88. http://dx.doi.org/10.1007/bf00794565.

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29

Robert, Julien, Jean-Michel Mignot, M. Sera und F. Iga. „Neutron diffraction study of the high magnetic field phase diagram of La-doped PrB6“. Journal of Physics: Conference Series 200, Nr. 1 (01.01.2010): 012166. http://dx.doi.org/10.1088/1742-6596/200/1/012166.

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30

Tanigawa, S., S. Terakado, Y. Iwase, R. Suzuki, T. Komatsubara und Y. Ōnuki. „The momentum distribution of electrons in LaB6, CeB6, PrB6 and NdB6 by position annihilation“. Journal of Magnetism and Magnetic Materials 52, Nr. 1-4 (Oktober 1985): 313–16. http://dx.doi.org/10.1016/0304-8853(85)90289-6.

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31

Azen, Edwin A. „Genetics of Salivary Protein Polymorphisms“. Critical Reviews in Oral Biology & Medicine 4, Nr. 3 (April 1993): 479–85. http://dx.doi.org/10.1177/10454411930040033201.

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Human salivary PRPs are determined by six closely linked genes on chromosome 12pl3.2. The many PRPs show complex electrophoretic patterns that differ between individuals and reflect numerous genetic polymorphisms. Frequent length and null polymorphisms are common among PRPs. Common themes emerge as a background for these PRP polymorphisms. First, posttranslational proteolysis occurs with double-banded patterns among acidic PRPs and the generation of numerous basic PRPs derived from precursor proteins. Specific mutations may interfere with proteolysis, preventing generation of double-banded acidic PRPs (as with the Pa protein) or of small basic PRPs from precursor proteins (as with Pm proteins). Second, single cysteine substitutions in PRPs (Pa from PRH1 and Gl 8 from PRB3) may lead to disulfide bonded homodimers as well as heterodimers with salivary peroxidase. Third, frequent homologous and unequal crossing-over within the PRP gene cluster leads to frequent protein size-variants (intragenic events as with the GI protein variants) and the generation of the PRB2 /1 fusion gene (intergenic event) with deletion of the PRB1 coding region and absence of multiple PRB 1 coded proteins (Ps, Pm, Pe) in PRB2/1 homozygotes. Fourth, null mutations may also be produced (as with PsO and Gl 0) by single nucleotide changes.

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32

Keilin, V. E., I. A. Kovalev, S. L. Kruglov, D. I. Shutova, A. E. Vorobjeva, M. I. Medvedev und A. K. Shikov. „Considerable stability increase of Nb3Sn multifilamentary wire internally doped with a large heat capacity substance (PrB6)“. Superconductor Science and Technology 22, Nr. 8 (15.07.2009): 085007. http://dx.doi.org/10.1088/0953-2048/22/8/085007.

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33

Davis, Paul R., Mark A. Gesley, Gregory A. Schwind, Lynwood W. Swanson und Joseph J. Hutta. „Comparison of thermionic cathode parameters of low index single crystal faces of LaB6, CeB6 and PrB6“. Applied Surface Science 37, Nr. 4 (August 1989): 381–94. http://dx.doi.org/10.1016/0169-4332(89)90499-6.

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34

Wang, Jun, Lihong Bao, O. Tegus, Luo Meng Chao und Zizhong Liu. „Nanocrystalline Eu-doped PrB6 hexaborides with tunable optical absorption: A combined experimental and density functional theory study“. Physica B: Condensed Matter 624 (Januar 2022): 413364. http://dx.doi.org/10.1016/j.physb.2021.413364.

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35

Keilin, V. E., I. A. Kovalev, S. L. Kruglov, V. I. Sсherbakov, D. I. Shutova, A. E. Vorobjeva, N. I. Salunin und L. V. Potanina. „Cu/Nb-Ti MRI wires with improved stability by incorporating filaments of large heat capacity substance PrB6“. Superconductor Science and Technology 28, Nr. 3 (02.02.2015): 035012. http://dx.doi.org/10.1088/0953-2048/28/3/035012.

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36

Wang, Yan, Jingjing Zhao, Xinyu Yang, Hefa Cheng, Bing Xu, Shuyu Ning und Jiuxing Zhang. „Density of Feed Rod Dependence of the PrB6 Single Crystal Grown by the Optical Floating Zone Technique“. Crystal Research and Technology 54, Nr. 8 (25.06.2019): 1800276. http://dx.doi.org/10.1002/crat.201800276.

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37

Otani, S., H. Nakagawa, Y. Nishi und N. Kieda. „Floating Zone Growth and High Temperature Hardness of Rare-Earth Hexaboride Crystals: LaB6, CeB6, PrB6, NdB6, and SmB6“. Journal of Solid State Chemistry 154, Nr. 1 (Oktober 2000): 238–41. http://dx.doi.org/10.1006/jssc.2000.8842.

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38

Hung, Sheng-Hsiung, und Horng-Tay Jeng. „Topological Phase and Strong Correlation in Rare-Earth Hexaborides XB6 (X = La, Ce, Pr, Nd, Pm, Sm, Eu)“. Materials 13, Nr. 19 (01.10.2020): 4381. http://dx.doi.org/10.3390/ma13194381.

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The rare-earth hexaboride SmB6, known as the topological Kondo insulator, has attracted tremendous attention in recent years. It was revealed that the topological phase of SmB6 is insensitive to the value of on-site Coulomb interactions (Hubbard U), indicating that the topological phase in SmB6 is robust against strong correlations. On the contrary, the isostructural YbB6 displays a sensitivity to the Hubbard U value. As U increases, YbB6 transforms from topological Kondo insulator to trivial insulator, showing the weak robustness of the topological phase of YbB6 against U. Consequently, the dependence of the topological phase on Hubbard U is a crucial issue in the rare-earth hexaboride family. In this work, we investigate the structural and electronic properties of rare-earth hexaboride compounds through first-principles calculations based on density functional theory. By taking the strong correlations into consideration using a wide range of on-site U values, we study the evolution of the topological phases in rare-earth hexaboride (XB6, X = La, Ce, Pr, Nd, Pm, Sm, Eu). Unlike YbB6, the topological trends in all the examples of XB6 studied in this work are insensitive to the U values. We conclude that in addition to the well-known SmB6, PmB6, NdB6 and EuB6 are also topologically nontrivial compounds, whereas LaB6, CeB6 and PrB6 are topologically trivial metal.

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39

Prescott, Lauren S., Alaina J. Brown, Charlotte C. Sun, Charles F. Levenback, Lois M. Ramondetta und Diane C. Bodurka. „Transfusion utilization at the end of life.“ Journal of Clinical Oncology 32, Nr. 30_suppl (20.10.2014): 303. http://dx.doi.org/10.1200/jco.2014.32.30_suppl.303.

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303 Background: Both the AMA’s Consortium for Performance Improvement and the Joint Commission have identified blood transfusions as one of the top 5 treatments that are over-utilized. We sought to quantify packed red blood cell transfusion (PRBT) utilization among ovarian cancer (OCa) pts in the last 6 months of life and identify risk factors for PRBT. Methods: We performed a retrospective cohort study of deceased OCa pts treated at our institution in their last 6 months of life from 2007-2011. Pts who underwent emergent procedures for bleeding were excluded. Demographic and end of life-interventions were compared between transfusion and non-transfusion groups using chi-squared and univariate analysis. End-of-life interventions included anti-cancer treatment (chemotherapy radiation, or hormonal therapy), invasive procedure or abdominal surgery, as well as aggressive end-of-life care as defined by the NQF. Results: Of the 182 pts who met inclusion criteria, 59.9% received a PRBT in the last 6 months of life. Of those pts, 54.1% received a PRBT in the last 30 days of life. Mean hgb level at which pts were transfused was 8.4 ± 0.9 g/dL. Pts received a combined total of 436 units of PRBC. The majority of pts received 1 transfusion (n=50, range 1-16). Mean number of total units transfused was 4 (range 1-25). The most common indication for PRBT was hgb < 9 g/dL (61.1%), followed by symptomatic anemia (21.9%). There was no difference in PRBT rate between pts who received medical interventions in the last 6 months of life v. those who did not. Specifically, transfusion rate was not correlated with: anti-cancer treatments (93.2% v. 92.7%, OR 0.93; 95% CI (0.29, 2.96)), invasive procedures (82.2% v. 81.7%, OR 0.96; CI (0.45,2.08)), abdominal surgery (11.0% v. 11.0%, OR 1.01; 95% CI(0.39,2.59)), or aggressive end-of-life care (46.6% v. 56.9%, OR 1.51; 95% CI (0.83,2.74)). Conclusions: The majority of our pts received a PRBT in the last 6 months of life. We did not identify significant differences in clinical interventions between pts who received a PRBT and those who did not. Based on our analysis, transfusion practices in terminally ill OCa pts should be reevaluated. Creation of transfusion guidelines for cancer pts could potentially result in better utilization of blood bank resources.

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Chen, Xin, Teng-Teng Chen, Wan-Lu Li, Jun-Bo Lu, Li-Juan Zhao, Tian Jian, Han-Shi Hu, Lai-Sheng Wang und Jun Li. „Lanthanides with Unusually Low Oxidation States in the PrB3– and PrB4– Boride Clusters“. Inorganic Chemistry 58, Nr. 1 (13.12.2018): 411–18. http://dx.doi.org/10.1021/acs.inorgchem.8b02572.

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Liu, Chih-Yu, Cheng-Yu Ku, Li-Dan Hong und Shih-Meng Hsu. „Infinitely Smooth Polyharmonic RBF Collocation Method for Numerical Solution of Elliptic PDEs“. Mathematics 9, Nr. 13 (30.06.2021): 1535. http://dx.doi.org/10.3390/math9131535.

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In this article, a novel infinitely smooth polyharmonic radial basis function (PRBF) collocation method for solving elliptic partial differential equations (PDEs) is presented. The PRBF with natural logarithm is a piecewise smooth function in the conventional radial basis function collocation method for solving governing equations. We converted the piecewise smooth PRBF into an infinitely smooth PRBF using source points collocated outside the domain to ensure that the radial distance was always greater than zero to avoid the singularity of the conventional PRBF. Accordingly, the PRBF and its derivatives in the governing PDEs were always continuous. The seismic wave propagation problem, groundwater flow problem, unsaturated flow problem, and groundwater contamination problem were investigated to reveal the robustness of the proposed PRBF. Comparisons of the conventional PRBF with the proposed method were carried out as well. The results illustrate that the proposed approach could provide more accurate solutions for solving PDEs than the conventional PRBF, even with the optimal order. Furthermore, we also demonstrated that techniques designed to deal with the singularity in the original piecewise smooth PRBF are no longer required.

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Mahmood, Zanjbeel, Ryan Van Patten, Marina Z. Nakhla, Elizabeth W. Twamley, J. Vincent Filoteo und Dawn M. Schiehser. „REM Sleep Behavior Disorder in Parkinson’s Disease: Effects on Cognitive, Psychiatric, and Functional outcomes“. Journal of the International Neuropsychological Society 26, Nr. 9 (07.05.2020): 894–905. http://dx.doi.org/10.1017/s1355617720000430.

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AbstractObjective:Rapid eye movement sleep behavior disorder (RBD) affects 33–46% of patients with Parkinson’s disease (PD) and may be a risk factor for neuropsychological and functional deficits. However, the role of RBD on neuropsychological functioning in PD has yet to be fully determined. We, therefore, examined differences in neurocognitive performance, functional capacity, and psychiatric symptoms among nondemented PD patients with probable RBD (PD/pRBD+) and without (PD/pRBD−), and healthy comparison participants (HC).Methods:Totally, 172 participants (58 PD/pRBD+; 65 PD/pRBD−; 49 HC) completed an RBD sleep questionnaire, psychiatric/clinical questionnaires, performance-based and self-reported functional capacity measures, and underwent a comprehensive neuropsychological battery assessing attention/working memory, language, visuospatial function, verbal and visual learning and memory, and executive function.Results:Controlling for psychiatric symptom severity, the PD/pRBD+ group had poorer executive functioning and learning performance than the PD/pRBD− group and poorer neuropsychological functioning across all individual cognitive domains than the HCs. In contrast, PD/pRBD− patients had significantly lower scores than HCs only in the language domain. Moreover, PD/pRBD+ patients demonstrated significantly poorer medication management skills compared to HCs. Both PD groups reported greater depressive and anxiety severity compared to HCs; PD/pRBD+ group also endorsed greater severity of apathy compared to HCs.Conclusions:The presence of pRBD is associated with poorer neuropsychological functioning in PD such that PD patients with pRBD have poorer cognitive, functional, and emotional outcomes compared to HC participants and/or PD patients without pRBD. Our findings underscore the importance of RBD assessment for improved detection and treatment of neuropsychological deficits (e.g., targeted cognitive interventions).

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Ishikawa, Yasuko, Tomasz D. Pieczonka, Aneta M. Bragiel-Pieczonka, Harumichi Seta, Tadahiro Ohkuri, Yumi Sasanuma und Yuji Nonaka. „Long-Term Oral Administration of LLHK, LHK, and HK Alters Gene Expression Profile and Restores Age-Dependent Atrophy and Dysfunction of Rat Salivary Glands“. Biomedicines 8, Nr. 2 (20.02.2020): 38. http://dx.doi.org/10.3390/biomedicines8020038.

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Xerostomia, also known as dry mouth, is caused by a reduction in salivary secretion and by changes in the composition of saliva associated with the malfunction of salivary glands. Xerostomia decreases quality of life. In the present study, we investigated the effects of peptides derived from β-lactoglobulin C on age-dependent atrophy, gene expression profiles, and the dysfunction of salivary glands. Long-term oral administration of Leu57-Leu58-His59-Lys60 (LLHK), Leu58-His59-Lys60 (LHK) and His59-Lys60 (HK) peptides induced salivary secretion and prevented and/or reversed the age-dependent atrophy of salivary glands in older rats. The transcripts of 78 genes were upregulated and those of 81 genes were downregulated by more than 2.0-fold (p ≤ 0.05) after LHK treatment. LHK upregulated major salivary protein genes such as proline-rich proteins (Prpmp5, Prb3, Prp2, Prb1, Prp15), cystatins (Cst5, Cyss, Vegp2), amylases (Amy1a, Amy2a3), and lysozyme (Lyzl1), suggesting that LLHK, LHK, and HK restored normal salivary function. The AP-2 transcription factor gene (Tcfap2b) was also induced significantly by LHK treatment. These results suggest that LLHK, LHK, and HK-administration may prevent and/or reverse the age-dependent atrophy and functional decline of salivary glands by affecting gene expression.

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Di Pietro, Lorena, Mozhgan Boroumand, Wanda Lattanzi, Barbara Manconi, Martina Salvati, Tiziana Cabras, Alessandra Olianas et al. „A Catalog of Coding Sequence Variations in Salivary Proteins’ Genes Occurring during Recent Human Evolution“. International Journal of Molecular Sciences 24, Nr. 19 (09.10.2023): 15010. http://dx.doi.org/10.3390/ijms241915010.

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Saliva houses over 2000 proteins and peptides with poorly clarified functions, including proline-rich proteins, statherin, P-B peptides, histatins, cystatins, and amylases. Their genes are poorly conserved across related species, reflecting an evolutionary adaptation. We searched the nucleotide substitutions fixed in these salivary proteins’ gene loci in modern humans compared with ancient hominins. We mapped 3472 sequence variants/nucleotide substitutions in coding, noncoding, and 5′-3′ untranslated regions. Despite most of the detected variations being within noncoding regions, the frequency of coding variations was far higher than the general rate found throughout the genome. Among the various missense substitutions, specific substitutions detected in PRB1 and PRB2 genes were responsible for the introduction/abrogation of consensus sequences recognized by convertase enzymes that cleave the protein precursors. Overall, these changes that occurred during the recent human evolution might have generated novel functional features and/or different expression ratios among the various components of the salivary proteome. This may have influenced the homeostasis of the oral cavity environment, possibly conditioning the eating habits of modern humans. However, fixed nucleotide changes in modern humans represented only 7.3% of all the substitutions reported in this study, and no signs of evolutionary pressure or adaptative introgression from archaic hominins were found on the tested genes.

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Kryczka, Małgorzata. „STYL VINTAGE DROGA DO ZMIANY PARADYGMATU MYLENIA O KONKURENCJI JAKO SKUTEK PANDEMII I KONFLIKTU ZBROJNEGO NA UKRAINIE“. Folia Turistica 59 (31.12.2022): 3. http://dx.doi.org/10.5604/01.3001.0016.2789.

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Cel. Okrelenie wpywu niespodziewanych i nieoczywistych zdarze, jakie pojawiy si w latach 2020-2022, czyli pandemii COVID-19 i konfliktu zbrojnego na Ukrainie, na relacje wyraajce si w konkurencji lub wsppracy pomidzy przedsibiorstwami turystycznymi. Podjcie refleksji na temat obowizujcego paradygmatu mylenia o konkurencji. Zainicjowanie dyskusji w kwestii przewartociowania sposobw mylenia o konkurencji.Metoda. Badania empiryczne dotyczyy relacji midzy krakowskimi przedsibiorstwami turystycznymi. Prba (n=27) nie speniaa wymogw reprezentatywnoci. Badania przeprowadzono w okresie od czerwca do wrzenia 2022 roku technik ustrukturyzowanego wywiadu bezporedniego. Zastosowano celowy dobr prby badanej.Wyniki. Negatywnie wpywajce na funkcjonowanie brany turystycznej wydarzenia, spowodoway zmiany w relacjach pomidzy firmami konkurencyjnymi. Pocztkowa rywalizacja, w wikszoci przypadkw przerodzia si we wspprac oraz inne postrzeganie konkurencji.Ograniczenia bada i wnioskowania. Badania empiryczne dotycz maej grupy wybranych przedsibiorstw, zatem istnieje brak podstaw do uoglniania wynikw na ca krakowsk bran turystyczn, a tym bardziej na zmiany w caej brany.Implikacje praktyczne. Badania wskazuj, e pojawia si nowe spojrzenie na relacje pomidzy konkurencyjnymi przedsibiorstwami turystycznymi i w zwizku z istniejcym kryzysem o charakterze strukturalnym, spodziewane s zmiany paradygmatu mylenia o konkurencji.Oryginalno. Niespotykane dotd w dyskusji ekonomicznej zastosowanie stylu vintage, obecnego w sztuce i kulturze. Dyskusja na temat zmiany obowizujcego paradygmatu mylenia o konkurencji.Rodzaj pracy. Artyku prezentujcy wyniki bada empirycznych.

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Nakamura, K., T. Hasler, K. Morehead, R. J. Howard und M. Aikawa. „Plasmodium falciparum-infected erythrocyte receptor(s) for CD36 and thrombospondin are restricted to knobs on the erythrocyte surface.“ Journal of Histochemistry & Cytochemistry 40, Nr. 9 (September 1992): 1419–22. http://dx.doi.org/10.1177/40.9.1380530.

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Adherence of Plasmodium falciparum-infected RBCs (PRBC) to endothelial cells causes PRBC sequestration in cerebral microvessels and is considered to be a major contributor to the pathogenesis of cerebral malaria. Both CD36 and thrombospondin (TSP) are glycoproteins that mediate PRBC adherence to endothelial cells in vitro. Because they are both expressed on the surface of endothelial cells, they probably contribute to PRBC sequestration and vascular occlusion in vivo. By applying affinity labeling of receptor binding sites with purified ligands, we showed for the first time that both CD36 and TSP can bind independently to the PRBC surface and that the PRBC receptor(s) for CD36 and TSP are localized specifically to the electron-dense knob protrusions of the PRBC surface. These findings may help in efforts to develop a malaria vaccine to prevent cerebral malaria.

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Sajjadi, Elham, Konstantinos Venetis, Marianna Noale, Hatem A. Azim, Concetta Blundo, Giuseppina Bonizzi, Eugenia Di Loreto et al. „Breast Cancer during Pregnancy as a Special Type of Early-Onset Breast Cancer: Analysis of the Tumor Immune Microenvironment and Risk Profiles“. Cells 11, Nr. 15 (24.07.2022): 2286. http://dx.doi.org/10.3390/cells11152286.

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Breast cancer during pregnancy (PrBC) is a rare tumor with only a little information on its immune landscape. Here, we sought to characterize the cellular composition of the tumor microenvironment (TME) of PrBC and identify its differences from early-onset breast cancer (EOBC) in non-pregnant women. A total of 83 PrBC and 89 EOBC were selected from our Institutional registry and subjected to tumor-infiltrating lymphocytes (TILs) profiling and immunohistochemistry for CD4, CD8, forkhead box P3 (FOXP3), and programmed death-ligand 1 (PD-L1) (clone 22C3). A significantly lower frequency of hormone receptor (HR)-positive tumors was observed in PrBC. The prevalence of low/null PD-L1 and CD8+TILs was higher in PrBC than in the controls, specifically in HR+/HER2– breast cancers. PrBC had a significantly higher risk of relapse and disease-related death, compared to EOBC. The presence of TILs and each TIL subpopulation were significantly associated with disease relapse. Moreover, the death rate was higher in PrBC with CD8+ TILs. The TME of PrBC is characterized by specific patterns of TIL subpopulations with significant biological and prognostic roles. Routine assessment of TILs and TILs subtyping in these patients would be a valid addition to the pathology report that might help identify clinically relevant subsets of women with PrBC.

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Baron, David M., Binglan Yu, Chong Lei, Aranya Bagchi, Arkadi Beloiartsev, Christopher P. Stowell, Andrea U. Steinbicker, Rajeev Malhotra, Kenneth D. Bloch und Warren M. Zapol. „Pulmonary Hypertension in Lambs Transfused with Stored Blood Is Prevented by Breathing Nitric Oxide“. Anesthesiology 116, Nr. 3 (01.03.2012): 637–47. http://dx.doi.org/10.1097/aln.0b013e318246ef77.

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Background During extended storage, erythrocytes undergo functional changes. These changes reduce the viability of erythrocytes leading to release of oxyhemoglobin, a potent scavenger of nitric oxide. We hypothesized that transfusion of ovine packed erythrocytes (PRBC) stored for prolonged periods would induce pulmonary vasoconstriction in lambs, and that reduced vascular nitric oxide concentrations would increase this vasoconstrictor effect. Methods We developed a model of autologous stored blood transfusion in lambs (n = 36). Leukoreduced blood was stored for either 2 days (fresh PRBC) or 40 days (stored PRBC). Fresh or stored PRBC were transfused into donors instrumented for awake hemodynamic measurements. Hemodynamic effects of PRBC transfusion were also studied after infusion of N-nitro-L-arginine methyl-ester (25 mg/kg) or during inhalation of nitric oxide (80 ppm). Results Cell-free hemoglobin levels were higher in the supernatant of stored PRBC than in supernatant of fresh PRBC (Mean ± SD, 148 ± 20 vs. 41 ± 13 mg/dl, respectively, P < 0.001). Pulmonary artery pressure during transfusion of stored PRBC transiently increased from 13 ± 1 to 18 ± 1 mmHg (P < 0.001) and was associated with increased plasma hemoglobin concentrations. N-nitro-L-arginine methyl-ester potentiated the increase in pulmonary arterial pressure induced by transfusing stored PRBC, whereas inhalation of nitric oxide prevented the vasoconstrictor response. Conclusions Our results suggest that patients with reduced vascular nitric oxide levels because of endothelial dysfunction may be more susceptible to adverse effects of transfusing blood stored for prolonged periods. These patients might benefit from transfusion of fresh PRBC, when available, or inhaled nitric oxide supplementation to prevent the pulmonary hypertension associated with transfusion of stored PRBC.

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Stirdivant, S. M., H. E. Huber, D. R. Patrick, D. Defeo-Jones, E. M. McAvoy, V. M. Garsky, A. Oliff und D. C. Heimbrook. „Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product“. Molecular and Cellular Biology 12, Nr. 5 (Mai 1992): 1905–14. http://dx.doi.org/10.1128/mcb.12.5.1905-1914.1992.

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The human papillomavirus E7 gene can transform murine fibroblasts and cooperate with other viral oncogenes in transforming primary cell cultures. One biochemical property associated with the E7 protein is binding to the retinoblastoma tumor suppressor gene product (pRB). Biochemical properties associated with pRB include binding to viral transforming proteins (E1A, large T, and E7), binding to cellular proteins (E2F and Myc), and binding to DNA. The mechanism by which E7 stimulates cell growth is uncertain. However, E7 binding to pRB inhibits binding of cellular proteins to pRB and appears to block the growth-suppressive activity of pRB. We have found that E7 also inhibits binding of pRB to DNA. A 60-kDa version of pRB (pRB60) produced in reticulocyte translation reactions or in bacteria bound quantitatively to DNA-cellulose. Recombinant E7 protein used at a 1:1 or 10:1 molar ratio with pRB60 blocked 50 or greater than 95% of pRB60 DNA-binding activity, respectively. A mutant E7 protein (E7-Ala-24) with reduced pRB60-binding activity exhibited a parallel reduction in its blocking of pRB60 binding to DNA. An E7(20-29) peptide that blocks binding of E7 protein to pRB60 restored the DNA-binding activity of pRB60 in the presence of E7. Peptide E7(2-32) did not block pRB60 binding to DNA, while peptide E7(20-57) and an E7 fragment containing residues 1 to 60 partially blocked DNA binding. E7 species containing residues 3 to 75 were fully effective at blocking pRB60 binding to DNA. These studies indicate that E7 protein specifically blocks pRB60 binding to DNA and suggest that the E7 region responsible for this property lies between residues 32 and 75. The functional significance of these observations is unclear. However, we have found that a point mutation in pRB60 that impairs DNA-binding activity also blocks the ability of pRB60 to inhibit cell growth. This correlation suggests that the DNA-binding activity of retinoblastoma proteins contributes to their biological properties.

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Stirdivant, S. M., H. E. Huber, D. R. Patrick, D. Defeo-Jones, E. M. McAvoy, V. M. Garsky, A. Oliff und D. C. Heimbrook. „Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product.“ Molecular and Cellular Biology 12, Nr. 5 (Mai 1992): 1905–14. http://dx.doi.org/10.1128/mcb.12.5.1905.

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The human papillomavirus E7 gene can transform murine fibroblasts and cooperate with other viral oncogenes in transforming primary cell cultures. One biochemical property associated with the E7 protein is binding to the retinoblastoma tumor suppressor gene product (pRB). Biochemical properties associated with pRB include binding to viral transforming proteins (E1A, large T, and E7), binding to cellular proteins (E2F and Myc), and binding to DNA. The mechanism by which E7 stimulates cell growth is uncertain. However, E7 binding to pRB inhibits binding of cellular proteins to pRB and appears to block the growth-suppressive activity of pRB. We have found that E7 also inhibits binding of pRB to DNA. A 60-kDa version of pRB (pRB60) produced in reticulocyte translation reactions or in bacteria bound quantitatively to DNA-cellulose. Recombinant E7 protein used at a 1:1 or 10:1 molar ratio with pRB60 blocked 50 or greater than 95% of pRB60 DNA-binding activity, respectively. A mutant E7 protein (E7-Ala-24) with reduced pRB60-binding activity exhibited a parallel reduction in its blocking of pRB60 binding to DNA. An E7(20-29) peptide that blocks binding of E7 protein to pRB60 restored the DNA-binding activity of pRB60 in the presence of E7. Peptide E7(2-32) did not block pRB60 binding to DNA, while peptide E7(20-57) and an E7 fragment containing residues 1 to 60 partially blocked DNA binding. E7 species containing residues 3 to 75 were fully effective at blocking pRB60 binding to DNA. These studies indicate that E7 protein specifically blocks pRB60 binding to DNA and suggest that the E7 region responsible for this property lies between residues 32 and 75. The functional significance of these observations is unclear. However, we have found that a point mutation in pRB60 that impairs DNA-binding activity also blocks the ability of pRB60 to inhibit cell growth. This correlation suggests that the DNA-binding activity of retinoblastoma proteins contributes to their biological properties.

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