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Thematische Bibliographien / Pre-implantation development / Dissertationen

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Dissertationen zum Thema „Pre-implantation development“

Autor: Grafiati

Veröffentlicht am 24. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Sepulveda-Rincon, Lessly P. "Cell allocation patterns during mammalian pre-implantation development." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/43031/.

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The first cell differentiation in the mammalian embryo occurs during pre implantation development. At blastocyst stage two cell lineages can be distinguished: the inner cell mass (ICM), situated at the embryonic pole and the trophectoderm (TE) at the abembryonic pole. In murine embryos, it has been suggested that the first cleavage plane might be related with the embryonic-abembryonic (Em-Ab) axis at the blastocyst stage. So the daughter cells of the two-cell embryo might be already predisposed to a specific cell lineage further on development. The objective of the present thesis is to investi

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2

Spikings, Emma Catherine. "Mitochondrial DNA replication in pre-implantation embryonic development." Thesis, University of Birmingham, 2007. http://etheses.bham.ac.uk//id/eprint/45/.

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All eukaryotic cells possess mitochondrial DNA (mtDNA), which is maternally inherited through the oocyte, its replication being regulated by nuclear-encoded replication factors. It was hypothesised that mtDNA replication is highly regulated in oocytes, pre-implantation embryos and embryonic stem cells (ESCs) and that this may be disrupted following nuclear transfer (NT). MtDNA copy number decreased between 2-cell and 8-cell staged porcine embryos and increased between the morula and expanded blastocyst stages, coinciding with increased expression of mtDNA replication factors. Competent porcine

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3

Graham, Sarah Jane Lehar. "Novel molecular mechanisms in pre-implantation mouse embryo development." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708487.

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4

Abou, Sleiman Patrick Martin. "Development of pre-implantation genetic diagnosis for dominantly inherited cancer predisposition syndromes." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392335.

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5

Ozsoy, Sukran. "The role of L-proline in pre-implantation mouse embryo development in vitro." Thesis, The University of Sydney, 2011. http://hdl.handle.net/2123/8249.

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“The role of L-proline in pre-implantation mouse embryo development in vitro” Amino acids are known to play important roles in pre-implantation embryo development, including regulation of cell volume and metabolism. Inclusion of L-glutamine, glycine and betaine in embryo culture medium has been shown to improve development in vitro by acting as organic osmolytes, thereby regulating cell volume. The purpose of the present study was to determine the role of L-proline in pre-implantation mouse embryo development in vitro. In order to ensure the osmotic effect of L-proline, the osmolalit

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6

Champigny, Marc. "Expression of stem-loop binding protein during murine oogenesis and pre-implantation development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0025/MQ50733.pdf.

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7

Champigny, Marc. "Expression of stem-loop binding protein during murine oogenesis and pre-implantation development." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21522.

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The goal of the work presented here was to investigate the hypothesis that cytoplasmic SLBP is required for translation of somatic H1 mRNA, and their translational repression is due to a lack of SLBP in the cytoplasm of oocytes, and early cleavage-stage embryos. To this end, the expression of SLBP in murine oocytes and pre-implantation embryos was characterized by RT-PCR, Western blotting, and immunocytochemical. techniques.<br>mRNA encoding SLBP was detected throughout oogenesis and pre-implantation development, from small growing oocytes to the late blastocyst stage. SLBP protein was found i

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8

Bolton, Helen Louise. "Investigating the consequences of chromosome abnormalities arising during pre-implantation development of the mouse." Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/245199.

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The majority of human pre-implantation embryos created through in vitro fertilization (IVF) are mosaic as they are constituted of a mixture of diploid and aneuploid cells. Chromosome abnormalities are widely believed to contribute towards the relatively low success rates of IVF treatment. Consequently major efforts have been undertaken to develop effective tools to aid the selection of embryos with minimal abnormalities with the aim of improving clinical outcomes. However, the ultimate fate of mosaic embryos is not known. Human embryo research is limited by practical and ethical constraints, a

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9

Spyropoulou, Isabella. "Studies of methods to improve human pre- and peri-implantation embryo development in vitro." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365394.

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10

Loof, Gesa. "Elucidating the influence of chromatin topology on cellular identity in murine pre-implantation development." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22928.

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Präzise regulierte Genexpression, ist der Schlüssel zu erfolgreicher Embryonal-entwicklung. Die Expression von Zelltyp-spezifischen Transkriptionsfaktoren kann durch räumliche Interaktionen von Promotoren und Enhancern im Nukleus kontrolliert werden, aber auch durch 3D Faltung der DNA in größere organisatorische Einheiten wie “Topologically Associating Domains” (TADs) oder “A/B compartments”. Um die 3D Faltung in den Zelltypen des prä-implantations Embryos zu untersuchen, nutze ich ES und XEN Zellen, die stark dem Epiblast und dem primitiven Endoderm in der inneren Zellmasse des E4.5 Embryos

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11

Henery, Caroline Cecilia. "The influence of ploidy on the pre- and post-implantation development of mouse embryos." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/19837.

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Since the number of pre- and postimplantation human polyploid embryos available for analysis is very small and relatively few are available at any one centre, I have used appropriate experimental mouse models to facilitate a large scale investigation. One aim was to analyse the influence of ploidy on the cleavage rate of preimplantation embryos. A deviation from the optimum embryonic (diploid fertilized) cell number during this time might explain the poor development and failure of genetically abnormal embryos. Therefore, experimentally produced haploid, diploid, triploid and tetraploid embryo

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Harrouk, Wafa A. "Consequences of paternal exposure to the anti-cancer drug, cyclophosphamide, on rat pre-implantation development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0029/NQ64572.pdf.

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13

Harrouk, Wafa. "Consequences of paternal exposure to the anti-cancer drug, cyclophosphamide, on rat pre-implantation development." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36604.

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Administration of cyclophosphamide to males targets the germ cells and causes DNA damage including single strand breaks and DNA-DNA cross links. When males are treated with a chronic low dose of cyclophosphamide and then mated to normal females, progeny loss is manifested at the pre- and post-implantation stages of development. The earliest events that lead to embryonic loss were traced to day 2 of gestation when embryos had a decreased DNA synthesis profile and lower cell numbers than control litters. I investigated the hypothesis that chronic exposure of male rats to cyclophosphamide alters

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14

Doble, Maree. "Development of oral communication in infants with a profound hearing loss pre- and post-cochlear implantation /." Connect to full text, 2006. http://hdl.handle.net/2123/1220.

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Thesis (Ph. D.)--University of Sydney, 2006.<br>Title from title screen (viewed 19 Dec. 2006). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Communication Sciences and Disorders, Faculty of Health Sciences. Includes bibliographical references. Also issued in print.

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Loof, Gesa [Verfasser]. "Elucidating the influence of chromatin topology on cellular identity in murine pre-implantation development / Gesa Loof." Berlin : Humboldt-Universität zu Berlin, 2021. http://d-nb.info/1236570685/34.

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16

Doble, Maree G. "Development of Oral Communication in Infants with a Profound Hearing Loss: Pre- and Post-cochlear Implantation." Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/1220.

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An in-depth, longitudinal study of the speech and oral language development of eight infants with a profound hearing loss who receive early interventions focused on developing their auditory, speech and oral language capacity is presented in this thesis. Infants were tracked for two years, during the period when they are changed from a hearing aid to a cochlear implant. All infants in this study had their hearing loss identified early and were fitted with hearing aids between 1 and 7 months of age and received their cochlear implant between 8 and 16 months of age. They attended a number of dif

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Doble, Maree G. "Development of Oral Communication in Infants with a Profound Hearing Loss: Pre- and Post-cochlear Implantation." University of Sydney, 2006. http://hdl.handle.net/2123/1220.

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Doctor of Philosophy (PhD)<br>An in-depth, longitudinal study of the speech and oral language development of eight infants with a profound hearing loss who receive early interventions focused on developing their auditory, speech and oral language capacity is presented in this thesis. Infants were tracked for two years, during the period when they are changed from a hearing aid to a cochlear implant. All infants in this study had their hearing loss identified early and were fitted with hearing aids between 1 and 7 months of age and received their cochlear implant between 8 and 16 months of age.

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Balasuriya, A. S. "An investigation of DNA integrity biomarkers in gametogenesis and pre-implantation embryo development to predict reproductive potential." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1416269/.

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Unsuccessful fertilization, aberrant embryo development, implantation failure and recurrent miscarriages can occur despite any obvious reasons during assisted reproduction. DNA fragmentation and aneuploidy in gametes have been implicated as a possible cause for infertility, but the use of DNA fragmentation tests is controversial. The SCD-FISH test claims to analyse DNA fragmentation and aneuploidy in the same cell. In this thesis SCD-FISH was compared to single FISH and SCD, which showed that SCD-FISH was an unreliable method to study these parameters. Sperm preparation techniques in assisted

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19

Brimson, Christopher A. "The role of Hippo signalling in cell fate decisions in mouse embryonic stem cells and pre-implantation development." Thesis, University of Bath, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687385.

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The Hippo signalling pathway is a conserved kinase cascade involved in the regulation of tissue growth and organ size. Activation of the Hippo pathway through multiple upstream inputs results in phosphorylation and inactivation of the transcriptional co-activator, Yes associated protein (Yap). While the role of Yap as an oncogene and an effector of the Hippo pathway is well established, its role in cellular differentiation is less well known. In this present work I have utilised quantitative immunofluorescence analysis to examine the expression of Yap in the differentiation of mouse embryonic

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20

Le, Roux Ilouise. "The development of a pre-implantation tool for rating the individualised information and support needs of parents of young cochlear implant candidates." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/26062.

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Cochlear implantation is a proven and accepted option for young children with profound hearing loss. Cochlear implantation requires a professional team which should inform, guide, support and collaborate with parents constantly throughout the process. Existing programs for children with hearing loss and their families are generally designed on the basis of what experts believe they should contain, rather than on what parents actually wish to receive, which may often lead to a mismatch between the professionals view and the parents’ views of parental needs. In order to ensure that parental need

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21

Shaikly, Valerie Ruth. "An investigation into the factors associated with human pre-implantation embryo development and foetal maternal tolerance in the course of in vitro fertilization." Thesis, University of Essex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502139.

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22

Chung, Yu Hsiang, and 鍾宇翔. "Pre-implantation Development of Mouse Embryos in Microwells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/60023721727148669871.

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碩士<br>國立清華大學<br>奈米工程與微系統研究所<br>103<br>Assisted reproductive technologies (ART) are of increasing importance and impact worldwide. A crucial aspect of ART is to control and mimic the in vitro environment of mammalian to the in vivo one. Integration biotechnology with micro- and nanotechnology is one of the necessary ways to improve ART. There are many platforms capable of nurturing cells in 3D, including using gel, microwells or hanging drop techniques. Microwells were chosen for the culture and investigation of early mouse embryos in this study, since microwells made of polydimethylsiloxane (P

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23

Tseng, Yu-Hsuan, and 曾于烜. "Effects of matrine on mouse pre-implantation embryo development." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/jbsdf7.

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碩士<br>中原大學<br>奈米科技碩士學位學程<br>106<br>Matrine is a legume belonging to the dry roots of legumes extracted, in many studies found that matrine has many effects, such as: anti-arrhythmia, inhibition of cancer cell proliferation, anti-inflammatory effects and other effects. Many studies also found that matrine can regulate the function of leukopenia in the body, and also found that cound inhibit the proliferation and induce apoptosis in many cancer cell lines. Previous studies in our laboratory have found that co-culture of blastocysts with matrine inhibits the proliferation of embryonic cells, prom

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Fu, Tzu-Yen, and 傅子彥. "Effects of angiogenin on the pre-implantation development of mouse embryos and establishment of an in vitro implantation model." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/56062218550924643632.

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碩士<br>中興大學<br>動物科學系所<br>95<br>A group of homologous ribonucleases (RNases) belonged to the RNase A superfamily has been isolated and characterized from various species. During the past decades, a lot of efforts have been devoted to the study of RNases, including DNA cloning, analyses of their catalytic activities and structures. However, little is known about the biological functions of the ubiquitous RNases in vivo, especially RNase 5, the angiogenin. Recently, it was demonstrated that the gene expression could be blocked after injection of double-stranded RNA (dsRNA) into organisms and the p

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25

Zander, Deirdre. "The impact of in vitro stress on pre-implantation embryo development, viability and mitochondrial homestasis." 2010. http://hdl.handle.net/2440/60987.

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It is recognised that the environment to which the fetus is exposed in utero, after implantation, can program longer term health outcomes and alter the possibility of disease onset later in life. It is becoming evident that the environment, to which the pre-implantation embryo is exposed, can also affect the ability of the embryo to form a viable pregnancy as well as altering fetal growth. Despite this understanding, little is known about the mechanism by which the environment can ‘program’ the pre-implantation embryo. Using model stress systems, either ammonium or DMO in the culture medium, t

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Biechele, Steffen. "The Role of the X-chromosomal Porcupine Homolog Gene in Mouse Development." Thesis, 2013. http://hdl.handle.net/1807/65503.

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WNT ligands are secreted proteins that act as signals between cells. WNTs activate several interconnected signaling pathways that are required for embryonic development as well as tissue homeostasis in adults. The X-chromosomal Porcn gene encodes a membrane-bound O-acyl transferase that is required for the acylation of all 19 WNT ligands encoded in the mammalian genome. Non-acylated WNTs fail to be secreted from the producing cell and thus do not activate downstream signaling targets. In my thesis research, I have investigated the function of Porcn in mouse embryonic development. In vitro, I h

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Maserati, Marc P. Jr. "Characterization of Genes Required for Preimplantation Embryo Development." 2013. https://scholarworks.umass.edu/theses/1135.

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Preimplantation embryo development in the mouse is a time of rapid cellular morphological and molecular changes leading to embryo implantation for the generation of offspring. The Mager lab studies these events occuring between fertilization and implantation in order to better understand the initial events which set the stage for all future aspects of development. The result of this research impacts many scientific disciplines including in-vitro based means of embryo culture, establishment of epigenetic marks, differentiation and cellular reprogramming and can be used in translational resear

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Huang, Tzu-Wei, and 黃子瑋. "Effects and regulatory mechanisms of berberine on mouse embryonic development in both pre- and post-implantation stages." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/zdwk86.

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碩士<br>中原大學<br>生物科技研究所<br>99<br>Berberine is an alkaloid isolated from Coptis Chinensis, Phellodendron and other plant extracts. Berberine is a traditional Chinese medicine in China which has been applied for a long time. Berberine has been evaluated as anti-diarrhea, anti-bacterial, anti-arrhythmic, anti-vascular smooth muscle proliferation and cholesterol-lowering. Berberine also performs a wide range of applications in the cardiovascular system and nervous system diseases. Several studies have demonstrated that berberine is able to induce apoptosis process in cancer cells. However, a study r

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MIHAJLOVIČ, Aleksandar. "The involvement of the Hippo signalling pathway in the first two cell-fate decisions of pre-implantation mouse embryo development." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-264795.

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