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1

Niakan, K. K., J. Han, R. A. Pedersen, C. Simon, and R. A. R. Pera. "Human pre-implantation embryo development." Development 139, no. 5 (2012): 829–41. http://dx.doi.org/10.1242/dev.060426.

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2

Sudheer, S., and J. Adjaye. "Functional genomics of human pre-implantation development." Briefings in Functional Genomics and Proteomics 6, no. 2 (2007): 120–32. http://dx.doi.org/10.1093/bfgp/elm012.

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3

Zhang, Pu, Marco Zucchelli, Sara Bruce, et al. "Transcriptome Profiling of Human Pre-Implantation Development." PLoS ONE 4, no. 11 (2009): e7844. http://dx.doi.org/10.1371/journal.pone.0007844.

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4

Ko, Minoru S. H. "Embryogenomics of pre-implantation mammalian development: current status." Reproduction, Fertility and Development 16, no. 2 (2004): 79. http://dx.doi.org/10.1071/rd03080.

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Pre-implantation development is marked by many critical molecular events, including the maternal to zygotic transition and the first differentiation of cells. Understanding such events is important, for both basic reproductive biology and practical applications, including regenerative medicine and livestock production. Scarcity of materials has hampered the progress of the field, but systematic genomics approaches are beginning to be applied to the study of pre-implantation development, resulting in unprecedented amounts of data about the pre-implantation process. The first step in embryogenom
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5

Liu, Weimin, and William S. B. Yeung. "LET-7 REGULATES PRE-IMPLANTATION MOUSE EMBRYO DEVELOPMENT." Fertility and Sterility 116, no. 3 (2021): e279. http://dx.doi.org/10.1016/j.fertnstert.2021.07.748.

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6

Justin, R. Chimka, and Jiang Leiying. "A note on interaction and pre-implantation development stages." Journal of Cell and Animal Biology 8, no. 6 (2014): 110–13. http://dx.doi.org/10.5897/jcab2014.0416.

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7

Krawchuk, Dayana, and Yojiro Yamanaka. "Understanding inter-strain differences in pre-implantation mouse development." Developmental Biology 356, no. 1 (2011): 204–5. http://dx.doi.org/10.1016/j.ydbio.2011.05.295.

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8

Jiang, Zongliang, Jiangwen Sun, Hong Dong, et al. "Transcriptional profiles of bovine in vivo pre-implantation development." BMC Genomics 15, no. 1 (2014): 756. http://dx.doi.org/10.1186/1471-2164-15-756.

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9

Chin, P. Y., J. G. Thompson, and S. A. Robertson. "Programming embryo development with a pre-implantation inflammatory insult." Journal of Reproductive Immunology 86, no. 1 (2010): 39. http://dx.doi.org/10.1016/j.jri.2010.06.075.

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10

Wu, Xiaoli, Sumit Sandhu, Nehal Patel, Barbara Triggs-Raine, and Hao Ding. "EMG1 is essential for mouse pre-implantation embryo development." BMC Developmental Biology 10, no. 1 (2010): 99. http://dx.doi.org/10.1186/1471-213x-10-99.

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11

Morgani, Sophie M., and Joshua M. Brickman. "LIF supports primitive endoderm expansion during pre-implantation development." Development 142, no. 20 (2015): 3488–99. http://dx.doi.org/10.1242/dev.125021.

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12

Herrick, J., A. Greene, W. Schoolcraft, and R. Krisher. "95 ROLE OF POLYAMINES IN BOVINE PRE-IMPLANTATION DEVELOPMENT." Reproduction, Fertility and Development 28, no. 2 (2016): 177. http://dx.doi.org/10.1071/rdv28n2ab95.

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Polyamines are involved in trophectoderm attachment and outgrowth, but little is known about their role in earlier stages of development. The objective of this study was to evaluate the effects of an inhibitor of polyamine synthesis (difluoromethylornithine, DFMO) on development (blastocyst formation and hatching) and cell allocation to the trophectoderm (TE, CDX2-positive) and inner cell mass (ICM, SOX2-positive) in the bovine embryo. Cumulus-oocyte complexes (COCs) were recovered from slaughterhouse ovaries and matured for 24 h in a defined maturation medium (5.0 mM glucose, 0.6 mM cysteine,
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13

Esmaeilzadeh, Khadijeh, Hamid Gourabi, Masoud Sheidai, Mostafa Fakhri, and Masood Bazrgar. "Taxol Improves Pre-Implantation Development Potential of Mouse Embryos." Gynecologic and Obstetric Investigation 85, no. 1 (2019): 94–99. http://dx.doi.org/10.1159/000502820.

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14

Hupalowska, Anna, Agnieszka Jedrusik, Meng Zhu, Mark T. Bedford, David M. Glover, and Magdalena Zernicka-Goetz. "CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development." Cell 175, no. 7 (2018): 1902–16. http://dx.doi.org/10.1016/j.cell.2018.11.027.

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15

Maganha, Juliana, Evelise de Souza Rocha, Marcos Antônio Fernandes Brandão, Vera Maria Peters, and Martha de Oliveira Guerra. "Embryo development alteration in rats treated with lapachol." Brazilian Archives of Biology and Technology 49, no. 6 (2006): 927–34. http://dx.doi.org/10.1590/s1516-89132006000700010.

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Lapachol, a naphthoquinone extracted from plants of the genus Tabebuia (family Bignoneaceae), showed multiple therapeutic activities. Pregnant Wistar rats were treated with Lapachol from the 1st to the 4th (pre-implantation period) and from 5th to 7th (implantation period) post insemination day (PID). Mothers were sacrificed on the 5th or on the15th PID. Number of corpora lutea, preimplantation embryo, blastocysts, live and dead fetuses and resorptions were counted. There were no signs of maternal toxicity. The number and the morphology of embryos, during oviduct development (pre-implantation
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16

Gutiérrez-Adán, A., M. Perez-Crespo, R. Fernandez-Gonzalez, et al. "Developmental Consequences of Sexual Dimorphism During Pre-implantation Embryonic Development." Reproduction in Domestic Animals 41, s2 (2006): 54–62. http://dx.doi.org/10.1111/j.1439-0531.2006.00769.x.

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17

Habibi, Razieh, Sayyed Morteza Hosseini, Faezeh Ghazvini Zadegan, et al. "Functional characterization of NANOG in goat pre-implantation embryonic development." Theriogenology 120 (October 2018): 33–39. http://dx.doi.org/10.1016/j.theriogenology.2018.07.023.

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18

Rankin, Tracy, Selma Soyal, and Jurrien Dean. "The mouse zona pellucida: folliculogenesis, fertility and pre-implantation development." Molecular and Cellular Endocrinology 163, no. 1-2 (2000): 21–25. http://dx.doi.org/10.1016/s0303-7207(99)00236-1.

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19

Tachibana, Masahito, Lisa Clepper, Michelle Sparman, Cathy Ramsey, and Shoukhrat Mitalipov. "The Role of NANOG During Primate Pre-Implantation Embryo Development." Biology of Reproduction 81, Suppl_1 (2009): 248. http://dx.doi.org/10.1093/biolreprod/81.s1.248.

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20

Moley, K. H., W. K. Vaughn, A. H. DeCherney, and M. P. Diamond. "Effect of diabetes mellitus on mouse pre-implantation embryo development." Reproduction 93, no. 2 (1991): 325–32. http://dx.doi.org/10.1530/jrf.0.0930325.

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21

Strnad, Petr, Stefan Gunther, Judith Reichmann, et al. "Inverted light-sheet microscope for imaging mouse pre-implantation development." Nature Methods 13, no. 2 (2015): 139–42. http://dx.doi.org/10.1038/nmeth.3690.

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22

Gao, Yawei, Xiaoyu Liu, Bin Tang, et al. "Protein Expression Landscape of Mouse Embryos during Pre-implantation Development." Cell Reports 21, no. 13 (2017): 3957–69. http://dx.doi.org/10.1016/j.celrep.2017.11.111.

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23

Petropoulos, S., S. P. Panula, J. P. Schell, and F. Lanner. "Single-cell RNA sequencing: revealing human pre-implantation development, pluripotency and germline development." Journal of Internal Medicine 280, no. 3 (2016): 252–64. http://dx.doi.org/10.1111/joim.12493.

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24

Li, Shuai, and Wipawee Winuthayanon. "Oviduct: roles in fertilization and early embryo development." Journal of Endocrinology 232, no. 1 (2017): R1—R26. http://dx.doi.org/10.1530/joe-16-0302.

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Animal oviducts and human Fallopian tubes are a part of the female reproductive tract that hosts fertilization and pre-implantation development of the embryo. With an increasing understanding of roles of the oviduct at the cellular and molecular levels, current research signifies the importance of the oviduct on naturally conceived fertilization and pre-implantation embryo development. This review highlights the physiological conditions within the oviduct during fertilization, environmental regulation, oviductal fluid composition and its role in protecting embryos and supplying nutrients. Fina
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25

Anifandis, G., C. I. Messini, K. Dafopoulos, and I. E. Messinis. "Genes and Conditions Controlling Mammalian Pre- and Post-implantation Embryo Development." Current Genomics 16, no. 1 (2015): 32–46. http://dx.doi.org/10.2174/1389202916666141224205025.

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26

Werner, Hendrikje, and Colin Stewart. "Dynamic composition of the nuclear envelope during mouse pre-implantation development." Mechanisms of Development 145 (July 2017): S95—S96. http://dx.doi.org/10.1016/j.mod.2017.04.244.

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27

Yamagata, K. "Capturing Epigenetic Dynamics During Pre-implantation Development Using Live Cell Imaging." Journal of Biochemistry 143, no. 3 (2007): 279–86. http://dx.doi.org/10.1093/jb/mvn001.

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28

Saitou, M., S. Kagiwada, and K. Kurimoto. "Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells." Development 139, no. 1 (2011): 15–31. http://dx.doi.org/10.1242/dev.050849.

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29

Komatsu, Kouji, and Toshihiko Fujimori. "Multiple phases in regulation of Nanog expression during pre-implantation development." Development, Growth & Differentiation 57, no. 9 (2015): 648–56. http://dx.doi.org/10.1111/dgd.12244.

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30

Scenna, F. N., J. L. Edwards, and F. N. Schrick. "139PROSTAGLANDIN F2± COMPROMISES DEVELOPMENT OF PRE-IMPLANTATION BOVINE EMBRYOS DURING COMPACTION." Reproduction, Fertility and Development 16, no. 2 (2004): 191. http://dx.doi.org/10.1071/rdv16n1ab139.

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Several studies have implicated prostaglandin F2α (PGF) as a major embryotoxic factor during early embryonic development in cattle. Elevated uterine concentrations of PGF were negatively associated with embryo development, quality and pregnancy rates (Schrick FN et al. 1993 Biol. Reprod. 49, 617–621; Hockett ME et al. 1998 J. Anim. Sci. 76 (Suppl 1), 241 abst; Seals RC et al. 1998 Prostaglandins 56, 377–389). Moreover, addition of PGF to culture medium decreased hatching rates of compacted morulae (Scenna FN et al. 2002 Theriogenology 53, 512 abst) and decreased development of pre-compacted (1
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31

Chen, Mo, Zhaoyan Wang, Zhiwen Zhang, et al. "Intelligence development of pre-lingual deaf children with unilateral cochlear implantation." International Journal of Pediatric Otorhinolaryngology 90 (November 2016): 264–69. http://dx.doi.org/10.1016/j.ijporl.2016.09.031.

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32

De Hertogh, R., I. Vanderheyden, S. Pampfer, D. Robin, and J. Delcourt. "Maternal insulin treatment improves pre-implantation embryo development in diabetic rats." Diabetologia 35, no. 5 (1992): 406–8. http://dx.doi.org/10.1007/bf02342434.

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33

Nishii, Kiyomasa, Yasushi Kobayashi, and Yosaburo Shibata. "Absence of connexin43 and connexin45 does not disturb pre- and peri-implantation development." Zygote 24, no. 3 (2015): 457–64. http://dx.doi.org/10.1017/s0967199415000386.

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SummaryGap junctional intercellular communication is assumed to play an important role during pre- and peri-implantation development. In this study, we eliminated connexin43 (Cx43) and connexin45 (Cx45), major gap junctional proteins in the pre- and peri-implantation embryo. We generated Cx43−/−Cx45−/− embryos by Cx43+/−Cx45+/− intercrossing, because mice deficient in Cx43 (Cx43−/−) exhibit perinatal lethality and those deficient in Cx45 (Cx45−/−) exhibit early embryonic lethality. Wild-type, Cx43−/−, Cx45−/−, and Cx43−/−Cx45−/− blastocysts all showed similar outgrowths in in vitro culture. Mo
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34

Fu, Bo, Hong Ma, and Di Liu. "Endogenous Retroviruses Function as Gene Expression Regulatory Elements During Mammalian Pre-implantation Embryo Development." International Journal of Molecular Sciences 20, no. 3 (2019): 790. http://dx.doi.org/10.3390/ijms20030790.

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Pre-implantation embryo development encompasses several key developmental events, especially the activation of zygotic genome activation (ZGA)-related genes. Endogenous retroviruses (ERVs), which are regarded as “deleterious genomic parasites”, were previously considered to be “junk DNA”. However, it is now known that ERVs, with limited conservatism across species, mediate conserved developmental processes (e.g., ZGA). Transcriptional activation of ERVs occurs during the transition from maternal control to zygotic genome control, signifying ZGA. ERVs are versatile participants in rewiring gene
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35

Navarro, M., C. Bluguermann, M. Von Meyeren, V. Bariani, C. Osycka, and A. Mutto. "2 Role of histone H3 lysine 9 trimethylation during bovine pre-implantation embryonic development." Reproduction, Fertility and Development 31, no. 1 (2019): 126. http://dx.doi.org/10.1071/rdv31n1ab2.

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Histones play an important role in DNA’s compaction and organisation into the cellular nucleus. Depending on which histone modification occurs, chromatin can take a conformation of heterochromatin or euchromatin, which are associated with gene repression or expression, respectively. Histone H3 lysine 9 (H3K9) trimethylation (H3K9me3) is associated with gene silencing. At least 3 methyltransferases are able to change the methylation status of H3K9: SUV39H1, SUV39H2, and SETDB1. In several mammalian species, modulation of H3K9 methylation status has been demonstrated to be necessary to achieve a
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36

Artus, Jérôme, Isabelle Hue, and Hervé Acloque. "Preimplantation development in ungulates: a ‘ménage à quatre’ scenario." Reproduction 159, no. 3 (2020): R151—R172. http://dx.doi.org/10.1530/rep-19-0348.

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In ungulates, early embryonic development differs dramatically from that of mice and humans and is characterized by an extended period of pre- and peri-implantation development in utero. After hatching from the zona pellucida, the ungulate blastocyst will stay free in the uterus for many days before implanting within the uterine wall. During this protracted peri-implantation period, an intimate dialog between the embryo and the uterus is established through a complex series of paracrine signals. The blastocyst elongates, leading to extreme growth of extra-embryonic tissues, and at the same tim
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37

Hedegger, Kathrin, Julia Philippou-Massier, Stefan Krebs, et al. "Sex-specific programming effects of parental obesity in pre-implantation embryonic development." International Journal of Obesity 44, no. 5 (2019): 1185–90. http://dx.doi.org/10.1038/s41366-019-0494-x.

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38

Den, Z. "Desmocollin 3 is required for pre-implantation development of the mouse embryo." Journal of Cell Science 119, no. 3 (2006): 482–89. http://dx.doi.org/10.1242/jcs.02769.

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39

O’Doherty, Alan M., David A. Magee, Lynee C. O’Shea, et al. "DNA methylation dynamics at imprinted genes during bovine pre-implantation embryo development." BMC Developmental Biology 15, no. 1 (2015): 13. http://dx.doi.org/10.1186/s12861-015-0060-2.

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40

Satterfield, Michael C., Gwonhwa Song, Kelli Kochan, et al. "Identification of Progesterone-Regulated Genes Governing Pre-implantation Conceptus Growth and Development." Biology of Reproduction 78, Suppl_1 (2008): 173. http://dx.doi.org/10.1093/biolreprod/78.s1.173a.

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41

Teson, J., K. Lee, L. Spate, and R. S. Prather. "142 DYNAMICS OF Tet FAMILY DURING PRE-IMPLANTATION DEVELOPMENT OF PORCINE EMBRYOS." Reproduction, Fertility and Development 24, no. 1 (2012): 183. http://dx.doi.org/10.1071/rdv24n1ab142.

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One of the key regulators of gene expression in mammals is DNA methylation. The Tet family (Tet1–3) is suggested to be involved in regulating the level of methylation by hydroxylating a methyl group from 5-methylcytosine to form 5-hydroxymethylcystosine. This hydroxylation alters the 3-dimensional structure of the DNA and results in altered gene expression. Previous studies conducted in the mouse have shown that Tet1 is important for inner cell mass specification by regulating the apparent level of methylation on a specific promoter region in blastocysts and Tet3 is related to the apparent pat
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42

Bogliotti, Y. S., L. B. Ferré, D. J. Humpal, and P. J. Ross. "68 EPIGENETIC REMODELING OF HISTONE 3 MARKS DURING BOVINE PRE-IMPLANTATION DEVELOPMENT." Reproduction, Fertility and Development 26, no. 1 (2014): 148. http://dx.doi.org/10.1071/rdv26n1ab68.

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During pre-implantation development, substantial epigenetic changes occur that are thought to play key roles in achieving embryonic genome activation and totipotency. Embryonic genome activation occurs at the 8- to 16-cell stage in cattle and, although it is a crucial step of development, the specific mechanisms involved are still poorly understood. The aim of this study was to determine whether 4 histone 3 marks associated with active genes are remodelled during oocyte and early embryo development in cattle. The dynamics of acetylation of lysine 27 (H3K27ac), di-methylation of lysine 79 (H3K7
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43

Dunwell, Thomas L., and Peter W. H. Holland. "A sister of NANOG regulates genes expressed in pre-implantation human development." Open Biology 7, no. 4 (2017): 170027. http://dx.doi.org/10.1098/rsob.170027.

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The NANOG homeobox gene plays a pivotal role in self-renewal and maintenance of pluripotency in human, mouse and other vertebrate embryonic stem cells, and in pluripotent cells of the blastocyst inner cell mass. There is a poorly studied and atypical homeobox locus close to the Nanog gene in some mammals which could conceivably be a cryptic paralogue of NANOG, even though the loci share only 20% homeodomain identity. Here we argue that this gene, NANOGNB (NANOG Neighbour) , is an extremely divergent duplicate of NANOG that underwent radical sequence change in the mammalian lineage. Like NANOG
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44

Kim, Jin-Moon, and Fugaku Aoki. "Mechanism of Gene Expression Reprogramming during Meiotic Maturation and Pre-Implantation Development." Journal of Mammalian Ova Research 21, no. 3 (2004): 89–96. http://dx.doi.org/10.1274/jmor.21.89.

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45

Montagner, M., A. Cropp, J. Swanson, R. Cederberg, P. Goncalves, and B. White. "144 ROLE OF GnRH ON MOUSE PRE-IMPLANTATION EMBRYONIC DEVELOPMENT IN VITRO." Reproduction, Fertility and Development 17, no. 2 (2005): 222. http://dx.doi.org/10.1071/rdv17n2ab144.

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The interaction between GnRH and its receptor on gonadotropes within the anterior pituitary gland represents a key point for regulation of the reproduction. In addition, GnRH can act in multiple extrapituitary tissues via autocrine/paracrine mechanisms. Protein for GnRH and mRNA for both GnRH and its receptor have been detected in human uterine endometrium and oviduct as well as in embryos at the morula/blastocyst stage in the mouse and human. Therefore, we hypothesized that GnRH may have a critical role in the development of pre-implantation embryos. To address this question, we examined the
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46

Abdul Rahman, Nor Shahida, Mimi Sophia Sarbandi, Wan Hafizah Wan Jusof, et al. "Increased mitochondrial distribution in early-cleaving embryos indicate successful pre-implantation development." Malaysian Journal of Fundamental and Applied Sciences 14, no. 4 (2018): 512–14. http://dx.doi.org/10.11113/mjfas.v14n4.1130.

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The timing of the first zygotic cleavage is an accurate predictor of embryo quality. Embryos that cleaved early have higher developmental viability compared to their late counterparts. During embryonic development, cleavage is affected by cellular metabolic processes performed by mitochondria and its synergistic interaction with endoplasmic reticulum (ER). However, in depth study on differences of mitochondria and ER ultrastructures in early- cleaving (EC) versus late- cleaving (LC) embryos is limited. This study compares mitochondria and ER ultrastructures of EC versus LC embryos using Confoc
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47

Moley, Kelle, and Michael Diamond. "Diabetes Mellitus: Effects on Oocyte and Pre-Implantation Embryo Growth and Development." Seminars in Reproductive Medicine 12, no. 02 (1994): 53–60. http://dx.doi.org/10.1055/s-2007-1016383.

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48

Chen, H. W., C. M. Su, and C. R. Tzeng. "Heme Oxygenase-1 as a Survival Factor in Pre-Implantation Embryo Development." Fertility and Sterility 84 (September 2005): S379—S380. http://dx.doi.org/10.1016/j.fertnstert.2005.07.994.

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49

Lv, Jie, Hui Liu, Shihuan Yu, et al. "Identification of 4438 novel lincRNAs involved in mouse pre-implantation embryonic development." Molecular Genetics and Genomics 290, no. 2 (2014): 685–97. http://dx.doi.org/10.1007/s00438-014-0952-z.

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50

Yokoo, Masaki, and Miho Mori. "Near-infrared laser irradiation improves the development of mouse pre-implantation embryos." Biochemical and Biophysical Research Communications 487, no. 2 (2017): 415–18. http://dx.doi.org/10.1016/j.bbrc.2017.04.076.

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