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Thematische Bibliographien / Prolin catabolism / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Prolin catabolism“

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Veröffentlicht am 25. Mai 2024

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1

Guerrier, Gilles. "Effect of salt-stress on proline metabolism in calli of Lycopersicon esculentum, Lycopersicon pennellii, and their interspecific hybrid." Canadian Journal of Botany 73, no. 12 (1995): 1939–46. http://dx.doi.org/10.1139/b95-206.

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Amino acid pools and enzyme activities of NH3-assimilation (glutamine synthetase, glutamate synthase), proline biosynthesis (pyrroline-5-carboxylate reductase), proline catabolism (proline dehydrogenase, proline oxidase), and ornithine transamination (ornithine transaminase) were determined in control and salinized (140 mM NaCl) calli from tomato roots. Three populations were used: the domestic salt-sensitive Lycopersicon esculentum Mill. cv. P-73, the wild salt-tolerant Lycopersicon pennellii (Correll) D'Arcy, accession PE-47, and their F1 interspecific cross, for which the relative growth ra

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2

Grantham, Barbara D., and J. Barrett. "Amino acid catabolism in the nematodes Heligmosomoides polygyrus and Panagrellus redivivus 2. Metabolism of the carbon skeleton." Parasitology 93, no. 3 (1986): 495–504. http://dx.doi.org/10.1017/s0031182000081208.

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SUMMARYAll of the enzymes of proline catabolism were present in Heligmosomoides polygyrus and Panagrellus redivivus and the activities were, in general, similar to those found in rat liver. Both nematodes were also shown to be able to catabolize the branched-chain amino acids leucine, isoleucine and valine, by pathways similar to those found in mammalian liver. There were no significant differences in amino acid catabolism between the animal-parasitic and free-living species of nematode.

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Phillips, Donald A., Eve S. Sande, J. A. C. Vriezen, Frans J. de Bruijn, Daniel Le Rudulier, and Cecillia M. Joseph. "A New Genetic Locus in Sinorhizobium meliloti Is Involved in Stachydrine Utilization." Applied and Environmental Microbiology 64, no. 10 (1998): 3954–60. http://dx.doi.org/10.1128/aem.64.10.3954-3960.1998.

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ABSTRACT Stachydrine, a betaine released by germinating alfalfa seeds, functions as an inducer of nodulation genes, a catabolite, and an osmoprotectant in Sinorhizobium meliloti. Two stachydrine-inducible genes were found in S. meliloti1021 by mutation with a Tn5-luxAB promoter probe. Both mutant strains (S10 and S11) formed effective alfalfa root nodules, but neither grew on stachydrine as the sole carbon and nitrogen source. When grown in the absence or presence of salt stress, S10 and S11 took up [14C]stachydrine as well as wild-type cells did, but neither used stachydrine effectively as an

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4

Diab, Farès, Théophile Bernard, Alexis Bazire, Dominique Haras, Carlos Blanco, and Mohamed Jebbar. "Succinate-mediated catabolite repression control on the production of glycine betaine catabolic enzymes in Pseudomonas aeruginosa PAO1 under low and elevated salinities." Microbiology 152, no. 5 (2006): 1395–406. http://dx.doi.org/10.1099/mic.0.28652-0.

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Glycine betaine (GB) and its immediate precursors choline and carnitine, dimethylsulfonioacetate, dimethylsulfoniopropionate, ectoine and proline were effective osmoprotectants for Pseudomonas aeruginosa, but pipecolate, trehalose and sucrose had no osmoprotective effect. GB was accumulated stably or transiently when succinate or glucose, respectively, was used as a carbon and energy source. The catabolite repression mediated by succinate occurred at both low and high salinities, and it did not involve the global regulators Vfr and Crc. A proteomic analysis showed that at least 21 proteins wer

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5

Tanner, John J. "Structural biology of proline catabolism." Amino Acids 35, no. 4 (2008): 719–30. http://dx.doi.org/10.1007/s00726-008-0062-5.

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6

Deutch, Charles E., James M. Hasler, Rochelle M. Houston, Manish Sharma, and Valerie J. Stone. "Nonspecific inhibition of proline dehydrogenase synthesis in Escherichia coli during osmotic stress." Canadian Journal of Microbiology 35, no. 8 (1989): 779–85. http://dx.doi.org/10.1139/m89-130.

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L-Proline, which is accumulated by Escherichia coli during growth in media of high osmolality, also induces the synthesis of the enzyme degrading it to glutamate. To determine if proline catabolism is inhibited during osmotic stress, proline utilization and the formation of proline dehydrogenase were examined in varying concentrations of NaCl and sucrose. Although the specific growth rate of E. coli with proline as the sole nitrogen source diminished as the solute osmolality increased, a comparable reduction in growth rate occurred with ammonium as the primary nitrogen source. Proline cataboli

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7

Pallag, Gergely, Sara Nazarian, Dora Ravasz, et al. "Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited." International Journal of Molecular Sciences 23, no. 9 (2022): 5111. http://dx.doi.org/10.3390/ijms23095111.

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The oxidation of proline to pyrroline-5-carboxylate (P5C) leads to the transfer of electrons to ubiquinone in mitochondria that express proline dehydrogenase (ProDH). This electron transfer supports Complexes CIII and CIV, thus generating the protonmotive force. Further catabolism of P5C forms glutamate, which fuels the citric acid cycle that yields the reducing equivalents that sustain oxidative phosphorylation. However, P5C and glutamate catabolism depend on CI activity due to NAD+ requirements. NextGen-O2k (Oroboros Instruments) was used to measure proline oxidation in isolated mitochondria

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Belitsky, Boris R., and Abraham L. Sonenshein. "Modulation of Activity of Bacillus subtilis Regulatory Proteins GltC and TnrA by Glutamate Dehydrogenase." Journal of Bacteriology 186, no. 11 (2004): 3399–407. http://dx.doi.org/10.1128/jb.186.11.3399-3407.2004.

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ABSTRACT The Bacillus subtilis gltAB operon, encoding glutamate synthase, requires a specific positive regulator, GltC, for its expression and is repressed by the global regulatory protein TnrA. The factor that controls TnrA activity, a complex of glutamine synthetase and a feedback inhibitor, such as glutamine, is known, but the signal for modulation of GltC activity has remained elusive. GltC-dependent gltAB expression was drastically reduced when cells were grown in media containing arginine or ornithine or proline, all of which are inducers and substrates of the Roc catabolic pathway. Anal

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Cruz-Leite, Vanessa Rafaela Milhomem, André Luís Elias Moreira, Lana O’Hara Souza Silva, et al. "Proteomics of Paracoccidioides lutzii: Overview of Changes Triggered by Nitrogen Catabolite Repression." Journal of Fungi 9, no. 11 (2023): 1102. http://dx.doi.org/10.3390/jof9111102.

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Members of the Paracoccidioides complex are the causative agents of Paracoccidioidomycosis (PCM), a human systemic mycosis endemic in Latin America. Upon initial contact with the host, the pathogen needs to uptake micronutrients. Nitrogen is an essential source for biosynthetic pathways. Adaptation to nutritional stress is a key feature of fungi in host tissues. Fungi utilize nitrogen sources through Nitrogen Catabolite Repression (NCR). NCR ensures the scavenging, uptake and catabolism of alternative nitrogen sources, when preferential ones, such as glutamine or ammonium, are unavailable. The

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Chen, Siyun, Catharine E. White, George C. diCenzo, et al. "l-Hydroxyproline and d-Proline Catabolism in Sinorhizobium meliloti." Journal of Bacteriology 198, no. 7 (2016): 1171–81. http://dx.doi.org/10.1128/jb.00961-15.

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ABSTRACTSinorhizobium melilotiforms N2-fixing root nodules on alfalfa, and as a free-living bacterium, it can grow on a very broad range of substrates, includingl-proline and several related compounds, such as proline betaine,trans-4-hydroxy-l-proline (trans-4-l-Hyp), andcis-4-hydroxy-d-proline (cis-4-d-Hyp). Fourteenhypgenes are induced upon growth ofS. melilotiontrans-4-l-Hyp, and of those,hypMNPQencodes an ABC-typetrans-4-l-Hyp transporter andhypREencodes an epimerase that convertstrans-4-l-Hyp tocis-4-d-Hyp in the bacterial cytoplasm. Here, we present evidence that the HypO, HypD, and HypH

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Boncompagni, Eric, Laurence Dupont, Tam Mignot, et al. "Characterization of a Sinorhizobium melilotiATP-Binding Cassette Histidine Transporter Also Involved in Betaine and Proline Uptake." Journal of Bacteriology 182, no. 13 (2000): 3717–25. http://dx.doi.org/10.1128/jb.182.13.3717-3725.2000.

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ABSTRACT The symbiotic soil bacterium Sinorhizobium melilotiuses the compatible solutes glycine betaine and proline betaine for both protection against osmotic stress and, at low osmolarities, as an energy source. A PCR strategy based on conserved domains in components of the glycine betaine uptake systems from Escherichia coli(ProU) and Bacillus subtilis (OpuA and OpuC) allowed us to identify a highly homologous ATP-binding cassette (ABC) binding protein-dependent transporter in S. meliloti. This system was encoded by three genes (hutXWV) of an operon which also contained a fourth gene (hutH2

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12

Belostotsky, Ruth, and Yaacov Frishberg. "Catabolism of Hydroxyproline in Vertebrates: Physiology, Evolution, Genetic Diseases and New siRNA Approach for Treatment." International Journal of Molecular Sciences 23, no. 2 (2022): 1005. http://dx.doi.org/10.3390/ijms23021005.

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Hydroxyproline is one of the most prevalent amino acids in animal proteins. It is not a genetically encoded amino acid, but, rather, it is produced by the post-translational modification of proline in collagen, and a few other proteins, by prolyl hydroxylase enzymes. Although this post-translational modification occurs in a limited number of proteins, its biological significance cannot be overestimated. Considering that hydroxyproline cannot be re-incorporated into pro-collagen during translation, it should be catabolized following protein degradation. A cascade of reactions leads to productio

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13

Kijowska-Oberc, Joanna, Mikołaj K. Wawrzyniak, Liliana Ciszewska, and Ewelina Ratajczak. "Evaluation of P5CS and ProDH activity in Paulownia tomentosa (Steud.) as an indicator of oxidative changes induced by drought stress." PeerJ 12 (January 25, 2024): e16697. http://dx.doi.org/10.7717/peerj.16697.

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The aim of the study was to investigate changes in proline metabolism in seedlings of tree species during drought stress. One month old Paulownia tomentosa seedlings were exposed to moisture conditions at various levels (irrigation at 100, 75, 50 and 25% of field capacity), and then the material (leaves and roots) was collected three times at 10-day intervals. The activity of enzymes involved in proline metabolism was closely related to drought severity; however, proline content was not directly impacted. The activity of pyrroline-5-carboxylate synthetase (P5CS), which catalyzes proline biosyn

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Silao, Fitz Gerald S., Tong Jiang, Biborka Bereczky-Veress, et al. "Proline catabolism is a key factor facilitating Candida albicans pathogenicity." PLOS Pathogens 19, no. 11 (2023): e1011677. http://dx.doi.org/10.1371/journal.ppat.1011677.

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Candida albicans, the primary etiology of human mycoses, is well-adapted to catabolize proline to obtain energy to initiate morphological switching (yeast to hyphal) and for growth. We report that put1-/- and put2-/- strains, carrying defective Proline UTilization genes, display remarkable proline sensitivity with put2-/- mutants being hypersensitive due to the accumulation of the toxic intermediate pyrroline-5-carboxylate (P5C), which inhibits mitochondrial respiration. The put1-/- and put2-/- mutations attenuate virulence in Drosophila and murine candidemia models and decrease survival in hu

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Dellero, Younes, Vanessa Clouet, Nathalie Marnet, et al. "Leaf status and environmental signals jointly regulate proline metabolism in winter oilseed rape." Journal of Experimental Botany 71, no. 6 (2019): 2098–111. http://dx.doi.org/10.1093/jxb/erz538.

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Abstract Proline metabolism is an essential component of plant adaptation to multiple environmental stress conditions that is also known to participate in specific developmental phases, particularly in reproductive organs. Recent evidence suggested a possible role for proline catabolism in Brassica napus for nitrogen remobilization processes from source leaves at the vegetative stage. Here, we investigate transcript levels of Δ1-PYRROLINE-5-CARBOXYLATE SYNTHASE (P5CS) and PROLINE DEHYDROGENASE (ProDH) genes at the vegetative stage with respect to net proline biosynthesis and degradation fluxes

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Salmon, Jean-Michel, and Pierre Barre. "Improvement of Nitrogen Assimilation and Fermentation Kinetics under Enological Conditions by Derepression of Alternative Nitrogen-Assimilatory Pathways in an Industrial Saccharomyces cerevisiae Strain." Applied and Environmental Microbiology 64, no. 10 (1998): 3831–37. http://dx.doi.org/10.1128/aem.64.10.3831-3837.1998.

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ABSTRACT Metabolism of nitrogen compounds by yeasts affects the efficiency of wine fermentation. Ammonium ions, normally present in grape musts, reduce catabolic enzyme levels and transport activities for nonpreferred nitrogen sources. This nitrogen catabolite repression severely impairs the utilization of proline and arginine, both common nitrogen sources in grape juice that require the proline utilization pathway for their assimilation. We attempted to improve fermentation performance by genetic alteration of the regulation of nitrogen-assimilatory pathways in Saccharomyces cerevisiae. One m

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Moses, S., T. Sinner, A. Zaprasis, et al. "Proline Utilization by Bacillus subtilis: Uptake and Catabolism." Journal of Bacteriology 194, no. 4 (2011): 745–58. http://dx.doi.org/10.1128/jb.06380-11.

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18

Tang, Haiqing, and Shanshan Pang. "Proline Catabolism Modulates Innate Immunity in Caenorhabditis elegans." Cell Reports 17, no. 11 (2016): 2837–44. http://dx.doi.org/10.1016/j.celrep.2016.11.038.

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19

Deutch, Charles E. "l-Proline nutrition and catabolism in Staphylococcus saprophyticus." Antonie van Leeuwenhoek 99, no. 4 (2011): 781–93. http://dx.doi.org/10.1007/s10482-011-9552-7.

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20

Petersen, J. G., M. C. Kielland-Brandt, T. Nilsson-Tillgren, C. Bornaes, and S. Holmberg. "Molecular genetics of serine and threonine catabolism in Saccharomyces cerevisiae." Genetics 119, no. 3 (1988): 527–34. http://dx.doi.org/10.1093/genetics/119.3.527.

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Abstract The catabolic L-serine (L-threonine) deaminase of Saccharomyces cerevisiae allows the yeast to grow on media with L-serine or L-threonine as sole nitrogen source. A mutant, cha1 (catabolism of hydroxyamino acids), lacking this enzyme activity has been isolated. We have cloned the CHA1 gene by complementation of a cha1 mutation. Northern analysis showed that CHA1 mRNA has a size of about 1200 ribonucleotides. CHA1 is probably the structural gene for the enzyme; it is an abundant RNA in cells grown with serine and threonine as nitrogen source, whereas it is not detected when cells are g

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Vı́lchez, Susana, Maximino Manzanera, and Juan L. Ramos. "Control of Expression of DivergentPseudomonas putida put Promoters for Proline Catabolism." Applied and Environmental Microbiology 66, no. 12 (2000): 5221–25. http://dx.doi.org/10.1128/aem.66.12.5221-5225.2000.

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ABSTRACT Pseudomonas putida KT2440 uses proline as the sole C and N source. Utilization of this amino acid involves its uptake, which is mediated by the PutP protein, and its conversion into glutamate, mediated by the PutA protein. Sequence analysis revealed that theputA and putP genes are transcribed divergently. Expression from the putP and putAgenes was analyzed at the mRNA level in different host backgrounds in the absence and presence of proline. Expression from theput promoters was induced by proline. The transcription initiation points of the putP and putA genes were precisely mapped vi

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Edskes, Herman K., John A. Hanover, and Reed B. Wickner. "Mks1p Is a Regulator of Nitrogen Catabolism Upstream of Ure2p in Saccharomyces cerevisiae." Genetics 153, no. 2 (1999): 585–94. http://dx.doi.org/10.1093/genetics/153.2.585.

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Abstract The supply of nitrogen regulates yeast genes affecting nitrogen catabolism, pseudohyphal growth, and meiotic sporulation. Ure2p of Saccharomyces cerevisiae is a negative regulator of nitrogen catabolism that inhibits Gln3p, a positive regulator of DAL5, and other genes of nitrogen assimilation. Dal5p, the allantoate permease, allows ureidosuccinate uptake (Usa+) when cells grow on a poor nitrogen source such as proline. We find that overproduction of Mks1p allows uptake of ureidosuccinate on ammonia and lack of Mks1p prevents uptake of ureidosuccinate or Dal5p expression on proline. O

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Tanner, John J. "Structural Biology of Proline Catabolic Enzymes." Antioxidants & Redox Signaling 30, no. 4 (2019): 650–73. http://dx.doi.org/10.1089/ars.2017.7374.

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Lee, Haehee, and Sangkee Rhee. "Structural and mutational analyses of the bifunctional arginine dihydrolase and ornithine cyclodeaminase AgrE from the cyanobacterium Anabaena." Journal of Biological Chemistry 295, no. 17 (2020): 5751–60. http://dx.doi.org/10.1074/jbc.ra120.012768.

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In cyanobacteria, metabolic pathways that use the nitrogen-rich amino acid arginine play a pivotal role in nitrogen storage and mobilization. The N-terminal domains of two recently identified bacterial enzymes: ArgZ from Synechocystis and AgrE from Anabaena, have been found to contain an arginine dihydrolase. This enzyme provides catabolic activity that converts arginine to ornithine, resulting in concomitant release of CO2 and ammonia. In Synechocystis, the ArgZ-mediated ornithine–ammonia cycle plays a central role in nitrogen storage and remobilization. The C-terminal domain of AgrE contains

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Culham, Doreen E., Katherine S. Emmerson, Bonnie Lasby, et al. "Genes encoding osmoregulatory proline/glycine betaine transporters and the proline catabolic system are present and expressed in diverse clinical Escherichia coli isolates." Canadian Journal of Microbiology 40, no. 5 (1994): 397–402. http://dx.doi.org/10.1139/m94-065.

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Sixty-three clinical isolates identified as Escherichia coli, 30 from the human urinary tract and 33 derived from other human origins, were screened for proline/glycine betaine transporters similar to those that support proline catabolism and proline- or glycine betaine-based osmoregulation in E. coli K-12. Both molecular (DNA- and protein-based) analyses and physiological tests were performed. All tests were calibrated with E. coli K-12 derivatives from which genetic loci putP (encoding a proline transporter required for proline catabolism), proP, and (or) proU (loci encoding osmoregulatory p

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Glenn, A. R., S. Holliday, and M. J. Dilworth. "The transport and catabolism of l-proline by cowpeaRhizobiumNGR 234." FEMS Microbiology Letters 82, no. 3 (1991): 307–12. http://dx.doi.org/10.1111/j.1574-6968.1991.tb04900.x.

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Obungu, Victor H., Job K. Kiaira, R. Muturi Njogu, and Norah K. Olembo. "Catabolism of proline by procyclic culture forms of Trypanosoma congolense." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 123, no. 1 (1999): 59–65. http://dx.doi.org/10.1016/s0305-0491(99)00040-1.

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Casalino, Laura, Stefania Comes, Giuseppina Lambazzi, et al. "Control of embryonic stem cell metastability by l-proline catabolism." Journal of Molecular Cell Biology 3, no. 2 (2011): 108–22. http://dx.doi.org/10.1093/jmcb/mjr001.

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Ayliffe, Michael A., Heidi J. Mitchell, Karen Deuschle, and Anthony J. Pryor. "Comparative analysis in cereals of a key proline catabolism gene." Molecular Genetics and Genomics 274, no. 5 (2005): 494–505. http://dx.doi.org/10.1007/s00438-005-0048-x.

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Igouzoul, A., J. Douchin, E. Audet-Walsh, F. Boisvert, and V. Giroux. "A10 PROLINE METABOLISM AFFECTS CANCER STEM CELLS IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA." Journal of the Canadian Association of Gastroenterology 7, Supplement_1 (2024): 6. http://dx.doi.org/10.1093/jcag/gwad061.010.

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Abstract Background Esophageal squamous cell carcinoma (ESCC) is highly deadly with a 5-year survival rate of only 16%, partly due to treatment resistance. Resistance is associated, among others, with the presence of cancer stem cells (CSC). Previous work in the laboratory has shown that prolonged exposure to anticancer treatments such as radiation and/or 5-FU leads to increased number of CSCs. Interestingly, disruption of amino acid metabolism, especially decreased proline levels, has been observed in treated cells. Proline is a non-essential amino acid that can either be uptake from the envi

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Huberman, Lori B., Vincent W. Wu, David J. Kowbel, et al. "DNA affinity purification sequencing and transcriptional profiling reveal new aspects of nitrogen regulation in a filamentous fungus." Proceedings of the National Academy of Sciences 118, no. 13 (2021): e2009501118. http://dx.doi.org/10.1073/pnas.2009501118.

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Sensing available nutrients and efficiently utilizing them is a challenge common to all organisms. The model filamentous fungus Neurospora crassa is capable of utilizing a variety of inorganic and organic nitrogen sources. Nitrogen utilization in N. crassa is regulated by a network of pathway-specific transcription factors that activate genes necessary to utilize specific nitrogen sources in combination with nitrogen catabolite repression regulatory proteins. We identified an uncharacterized pathway-specific transcription factor, amn-1, that is required for utilization of the nonpreferred nitr

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Silva, Nicola, Maikel Castellano-Pozo, Kenichiro Matsuzaki, et al. "Proline-specific aminopeptidase P prevents replication-associated genome instability." PLOS Genetics 18, no. 1 (2022): e1010025. http://dx.doi.org/10.1371/journal.pgen.1010025.

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Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects of cellular metabolism is less understood. We show that aminopeptidase P (APP1), a metalloprotease involved in the catabolism of peptides containing proline residues near their N-terminus, prevents replication-associated genome instability. Functional analysis of C. elegans mutants lacking APP-1 demonstrates that germ cells display replication defects includi

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Iyer, Suresh, and Allan Caplan. "Products of Proline Catabolism Can Induce Osmotically Regulated Genes in Rice." Plant Physiology 116, no. 1 (1998): 203–11. http://dx.doi.org/10.1104/pp.116.1.203.

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Curtis, Jason, Georgia Shearer, and Daniel H. Kohl. "Bacteroid Proline Catabolism Affects N2 Fixation Rate of Drought-Stressed Soybeans." Plant Physiology 136, no. 2 (2004): 3313–18. http://dx.doi.org/10.1104/pp.104.044024.

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Glenn, A. "The transport and catabolism of ?-proline by cowpea Rhizobium NGR 234." FEMS Microbiology Letters 82, no. 3 (1991): 307–12. http://dx.doi.org/10.1016/0378-1097(91)90279-j.

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Gloux, Karine, and Daniel Le Rudulier. "Transport and catabolism of proline betaine in salt-stressed Rhizobium meliloti." Archives of Microbiology 151, no. 2 (1989): 143–48. http://dx.doi.org/10.1007/bf00414429.

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Cabassa-Hourton, Cécile, Peter Schertl, Marianne Bordenave-Jacquemin, et al. "Proteomic and functional analysis of proline dehydrogenase 1 link proline catabolism to mitochondrial electron transport in Arabidopsis thaliana." Biochemical Journal 473, no. 17 (2016): 2623–34. http://dx.doi.org/10.1042/bcj20160314.

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Molecular and biochemical analyses indicate a key role of proline dehydrogenase 1 in proline oxidation. ProDH1 binds to mitochondrial membranes, is part of small respiratory chain complex and delivers its electrons to the respiratory chain.

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Oh, Glenda Guek Khim, Brendan M. O’Leary, Santiago Signorelli, and A. Harvey Millar. "Alternative oxidase (AOX) 1a and 1d limit proline-induced oxidative stress and aid salinity recovery in Arabidopsis." Plant Physiology 188, no. 3 (2021): 1521–36. http://dx.doi.org/10.1093/plphys/kiab578.

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Abstract Proline (Pro) catabolism and reactive oxygen species production have been linked in mammals and Caenorhabditis elegans, while increases in leaf respiration rate follow Pro exposure in plants. Here, we investigated how alternative oxidases (AOXs) of the mitochondrial electron transport chain accommodate the large, atypical flux resulting from Pro catabolism and limit oxidative stress during Pro breakdown in mature Arabidopsis (Arabidopsis thaliana) leaves. Following Pro treatment, AOX1a and AOX1d accumulate at transcript and protein levels, with AOX1d approaching the level of the typic

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Falcioni, Francesco, Lars M. Blank, Oliver Frick, Andreas Karau, Bruno Bühler, and Andreas Schmid. "Proline Availability Regulates Proline-4-Hydroxylase Synthesis and Substrate Uptake in Proline-Hydroxylating Recombinant Escherichia coli." Applied and Environmental Microbiology 79, no. 9 (2013): 3091–100. http://dx.doi.org/10.1128/aem.03640-12.

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ABSTRACTMicrobial physiology plays a crucial role in whole-cell biotransformation, especially for redox reactions that depend on carbon and energy metabolism. In this study, regio- and enantio-selective proline hydroxylation with recombinantEscherichia coliexpressing proline-4-hydroxylase (P4H) was investigated with respect to its interconnectivity to microbial physiology and metabolism. P4H production was found to depend on extracellular proline availability and on codon usage. Medium supplementation with proline did not alterp4hmRNA levels, indicating that P4H production depends on the avail

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Nakada, Yuji, Takayuki Nishijyo, and Yoshifumi Itoh. "Divergent Structure and Regulatory Mechanism of Proline Catabolic Systems: Characterization of the putAP Proline Catabolic Operon of Pseudomonas aeruginosa PAO1 and Its Regulation by PruR, an AraC/XylS Family Protein." Journal of Bacteriology 184, no. 20 (2002): 5633–40. http://dx.doi.org/10.1128/jb.184.20.5633-5640.2002.

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ABSTRACT Pseudomonas aeruginosa PAO1 utilizes proline as the sole source of carbon and nitrogen via a bifunctional enzyme (the putA gene product) that has both proline dehydrogenase (EC 1.5.99.8) and pyrroline 5-carboxylate dehydrogenase (EC 1.5.1.12) activities. We characterized the pruR-putAP loci encoding the proline catabolic system of this strain. In contrast to the putA and putP (encoding proline permease) genes of other gram- negative bacteria, which are located at divergent or separate loci, Northern blotting demonstrated that the two genes form an operon in strain PAO1. While the phyl

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Vílchez, Susana, Lázaro Molina, Cayo Ramos, and Juan L. Ramos. "Proline Catabolism by Pseudomonas putida: Cloning, Characterization, and Expression of the put Genes in the Presence of Root Exudates." Journal of Bacteriology 182, no. 1 (2000): 91–99. http://dx.doi.org/10.1128/jb.182.1.91-99.2000.

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ABSTRACT Pseudomonas putida KT2442 is a root-colonizing strain which can use proline, one of the major components in root exudates, as its sole carbon and nitrogen source. A P. putida mutant unable to grow with proline as the sole carbon and nitrogen source was isolated after random mini-Tn5–Km mutagenesis. The mini-Tn5 insertion was located at the putAgene, which is adjacent to and divergent from the putPgene. The putA gene codes for a protein of 1,315 amino acid residues which is homologous to the PutA protein of Escherichia coli, Salmonella enterica serovar Typhimurium,Rhodobacter capsulatu

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Scazzocchio, Claudio, Victoria Gavrias, Beatriz Cubero, Cristina Panozzo, Martine Mathieu, and Béatrice Felenbok. "Carbon catabolite repression in Aspergillus nidulans: a review." Canadian Journal of Botany 73, S1 (1995): 160–66. http://dx.doi.org/10.1139/b95-240.

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We describe the experimental methodology that led to the discovery of the creA gene in Aspergillus nidulans. This gene codes for a transcriptional repressor mediating carbon catabolite repression in many pathways in this organism. We compare both the mode and the mechanism of action in two pathways subject to CreA-mediated repression. The genes comprising the ethanol regulon are subject to carbon catabolite repression independently of the nitrogen source, while the genes involved in proline utilization are repressed by glucose only when a repressing nitrogen source is also present. In the etha

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Quintero, María José, Alicia María Muro-Pastor, Antonia Herrero, and Enrique Flores. "Arginine Catabolism in the CyanobacteriumSynechocystis sp. Strain PCC 6803 Involves the Urea Cycle and Arginase Pathway." Journal of Bacteriology 182, no. 4 (2000): 1008–15. http://dx.doi.org/10.1128/jb.182.4.1008-1015.2000.

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ABSTRACT Cells of the unicellular cyanobacterium Synechocystissp. strain PCC 6803 supplemented with micromolar concentrations ofl-[14C]arginine took up, concentrated, and catabolized this amino acid. Metabolism ofl-[14C]arginine generated a set of labeled amino acids that included argininosuccinate, citrulline, glutamate, glutamine, ornithine, and proline. Production of [14C]ornithine preceded that of [14C]citrulline, and the patterns of labeled amino acids were similar in cells incubated withl-[14C]ornithine, suggesting that the reaction of arginase, rendering ornithine and urea, is the main

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Wei, Tong-Lu, Ze-Xian Wang, Yu-Fan He, et al. "Proline synthesis and catabolism-related genes synergistically regulate proline accumulation in response to abiotic stresses in grapevines." Scientia Horticulturae 305 (November 2022): 111373. http://dx.doi.org/10.1016/j.scienta.2022.111373.

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Dillon, E. Lichar, Darrell A. Knabe, and Guoyao Wu. "Lactate inhibits citrulline and arginine synthesis from proline in pig enterocytes." American Journal of Physiology-Gastrointestinal and Liver Physiology 276, no. 5 (1999): G1079—G1086. http://dx.doi.org/10.1152/ajpgi.1999.276.5.g1079.

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Hypocitrullinemia and hypoargininemia but hyperprolinemia are associated with elevated plasma concentration of lactate in infants. Because the small intestine may be a major organ for initiating proline catabolism via proline oxidase in the body and is the major source of circulating citrulline and arginine in neonates, we hypothesized that lactate is an inhibitor of intestinal synthesis of citrulline and arginine from proline. To test this hypothesis, jejunum was obtained from 14-day-old suckling pigs for preparation of enterocyte mitochondria and metabolic studies. Mitochondria were used for

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Nuxoll, Austin S., Steven M. Halouska, Marat R. Sadykov, et al. "CcpA Regulates Arginine Biosynthesis in Staphylococcus aureus through Repression of Proline Catabolism." PLoS Pathogens 8, no. 11 (2012): e1003033. http://dx.doi.org/10.1371/journal.ppat.1003033.

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Mitchell, Heidi J., Michael A. Ayliffe, Khalid Y. Rashid, and Anthony J. Pryor. "A rust-inducible gene from flax (fis1) is involved in proline catabolism." Planta 223, no. 2 (2005): 213–22. http://dx.doi.org/10.1007/s00425-005-0079-x.

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Silao, Fitz Gerald S., Meliza Ward, Kicki Ryman, et al. "Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans." PLOS Genetics 15, no. 2 (2019): e1007976. http://dx.doi.org/10.1371/journal.pgen.1007976.

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Li, Chunling, Fei Sun, Hoonsik Cho, et al. "CcpA Mediates Proline Auxotrophy and Is Required for Staphylococcus aureus Pathogenesis." Journal of Bacteriology 192, no. 15 (2010): 3883–92. http://dx.doi.org/10.1128/jb.00237-10.

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ABSTRACT Human clinical isolates of Staphylococcus aureus, for example, strains Newman and N315, cannot grow in the absence of proline, albeit their sequenced genomes harbor genes for two redundant proline synthesis pathways. We show here that under selective pressure, S. aureus Newman generates proline-prototrophic variants at a frequency of 3 × 10−6, introducing frameshift and missense mutations in ccpA or IS1811 insertions in ptsH, two regulatory genes that carry out carbon catabolite repression (CCR) in staphylococci and other Gram-positive bacteria. S. aureus Newman variants with mutation

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Lee, Tse-Min, and Chia-Hsiung Liu. "Regulation of NaCl-induced proline accumulation by calmodulin via modification of proline dehydrogenase activity in Ulva fasciata (Chlorophyta)." Functional Plant Biology 26, no. 6 (1999): 595. http://dx.doi.org/10.1071/pp99025.

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This paper examined the role of proline dehydrogenase (PDH; EC 1.4.3.1) in salinity-induced (adjusted by increasing NaCl contents in seawater) proline accumulation in the marine chlorophyte Ulva fasciata Delile, and also determined whether calmodulin modulates proline accumulation via a change in the activity and kinetic property of PDH. Upon exposure to varying salinity (30–120‰, that is, 317.9–1858 mМ NaCl in seawater) for 9 h, proline levels increased with increasing salinity, and were highly correlated with salinity (r2 = 0.97). In contrast, PDH-specific activity decreased with increasing

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