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Zeitschriftenartikel zum Thema „PTLA“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 6. Februar 2022

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1

Verma, Anita, Anissa M. Cheung, and Drusilla L. Burns. "Stabilization of the Pertussis Toxin Secretion Apparatus by the C Terminus of PtlD." Journal of Bacteriology 190, no. 21 (2008): 7285–90. http://dx.doi.org/10.1128/jb.01106-08.

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ABSTRACT Pertussis toxin (PT) is secreted from Bordetella pertussis by a type IV secretion system, known as the Ptl transporter, that comprises nine different proteins, PtlA to PtlI. In this study, we found that PtlD is required for the stability of three Ptl proteins, PtlE, PtlF, and PtlH. A region limited to the C-terminal 72 amino acids of PtlD (amino acids 392 to 463) was sufficient for maintaining the stability of PtlE, PtlF, and PtlH, although this region was not sufficient to support secretion of the toxin. Further analysis demonstrated that a stretch of 10 amino acids at the C-terminal

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Cangi, R., and D. A Atalay. "Effects of different bud loading levels on the yield, leaf and fruit characteristics of Hayward kiwifruit." Horticultural Science 33, No. 1 (2011): 23–28. http://dx.doi.org/10.17221/3736-hortsci.

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The effects of different levels of bud loading on the yield and some leaf and fruit characteristics in Hayward cultivar (A. deliciosa) in the province of Ordu, Turkey were examined during two growing seasons in 2000&ndash;2001. Six years old kiwifruit vines were pruned to carry the loads of 120, 180, 240 or 300 buds/vine on the canes with 12 buds. The study determined probable total leaf area (PTLA), probable total leaf number (PTLN), probable total leaf weight (PTLW) and yield per vine. Mean fruit weight (MFW) and soluble solid contents (SSC, %) of fruits were expressed. In addition, unit

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Steinkamp, Hermann J., Jürgen Rademaker, Christian Wissgott, et al. "Percutaneous Transluminal Laser Angioplasty versus Balloon Dilation for Treatment of Popliteal Artery Occlusions." Journal of Endovascular Therapy 9, no. 6 (2002): 882–88. http://dx.doi.org/10.1177/152660280200900623.

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Purpose: To compare the immediate results, complication rates, and long-term outcomes of percutaneous transluminal laser angioplasty (PTLA) versus balloon dilation alone in the treatment of popliteal artery occlusions. Methods: In a prospective nonrandomized study conducted between December 1994 and June 2000, 215 symptomatic patients with unilateral popliteal occlusions were treated with either dilation alone (88 patients: 52 men; mean age 62 years, range 48–83) or PTLA (127 patients: 70 men; mean age 64 years, range 49–86) using a 308-nm excimer laser followed by dilation. The average occlus

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Verma, Anita, and Drusilla L. Burns. "Requirements for Assembly of PtlH with the Pertussis Toxin Transporter Apparatus of Bordetella pertussis." Infection and Immunity 75, no. 5 (2007): 2297–306. http://dx.doi.org/10.1128/iai.00008-07.

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ABSTRACT PtlH is an essential component of the Ptl system, the type IV transporter responsible for secretion of pertussis toxin (PT) across the outer membrane of Bordetella pertussis. The nine Ptl proteins are believed to interact to form a membrane-spanning apparatus through which the toxin is secreted. In this study, we monitored the subcellular localization of PtlH in strains of B. pertussis lacking PT, lacking other Ptl proteins, or from which ATP has been depleted in order to gain insight into the requirements for assembly of PtlH with the remainder of the Ptl transporter complex that is

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Santoro, T. A. B., A. Oliveira Neto, C. A. L. G. de O. Forbicini, M. Linardi, J. L. Rodríguez, and E. Pastor. "Ethanol Electrooxidation on Pt with Lanthanum Oxide as Cocatalyst in a DAFC." International Journal of Electrochemistry 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/674150.

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Electrocatalytic activity toward ethanol electrooxidation of Pt particles in PtLa/C catalysts with different Pt : La ratios has been studied with different electrochemical and spectroscopic techniques, and the results were compared to those of Pt/C catalyst. Significant enhancement in the electrocatalytic activity has been achieved by depositing the Pt particles with lanthanum oxides/hydroxides using an alcohol reduction method. Compared to Pt/C catalyst, PtLa/C materials exhibit a lower onset potential and a higher electron-transfer rate constant for the investigated reaction. These studies i

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Takekawa, Shoichi, and Hiraku Yodono. "Current Status of Percutaneous Transluminal Laser Angioplasty (PTLA)." JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 15, Supplement (1994): 197–200. http://dx.doi.org/10.2530/jslsm1980.15.supplement_197.

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Ryan, Stephen, Reith Sarkar, Ahmet Bindayi, et al. "Positive surgical margins after radical nephrectomy for localized kidney cancer: Impact on survival." Journal of Clinical Oncology 37, no. 7_suppl (2019): 676. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.676.

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676 Background: Impact of positive surgical margins (PSM) in patients undergoing radical nephrectomy (RN) in localized renal cell carcinoma (RCC) is poorly understood. We sought to understand the impact of PSM for on overall survival (OS) after RN in clinically localized RCC. Methods: Retrospective analysis of patients from the US National Cancer Database who RN for clinically localized (cT1a-cT2b cN0M0) RCC between 2003-13, were stratified into their pathological stage group [pT1a, pT1b, pT2a, pT2b, and pT3a ( = Upstaged)] and analyzed by final margin status. Cox Regression Multivariable anal

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Steinkamp, H., D. Scheinert, H. Hettwer, et al. "PTLA-Rekanalisation von Femoralarterienstenosen/-okklusionen nach Angio-Seal™ Applikation." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 170, no. 01 (2008): 105–8. http://dx.doi.org/10.1055/s-2007-1011016.

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Peng, Yan, Min-Min Zhang, Zhen-Feng Chen, et al. "Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands." Bioinorganic Chemistry and Applications 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/565032.

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Starting from the active ingredient shikimic acid (SA) of traditional Chinese medicine and NH2(CH2)nOH, (n=2–6), we have synthesized a series of new water-soluble Pt(II) complexes PtLa–eCl2, where La–eare chelating diamine ligands with carbon chain covalently attached to SA (La–e= SA-NH(CH2)nNHCH2CH2NH2; La,n=2; Lb,n=3; Lc,n=4; Ld,n=5; Le,n=6). The results of the elemental analysis, LC-MS, capillary electrophoresis, and1H,13C NMR indicated that there was only one product (isomer) formed under the present experimental conditions, in which the coordinate mode of PtLa–eCl2was two-amine bidentate.

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Hutterer, Georg C., Martin Pichler, Thomas F. Chromecki, et al. "Comparison of the 2002 and 2010 version of the TNM classification system regarding the prediction of metastasis-free survival in patients with renal cell carcinoma." Journal of Clinical Oncology 30, no. 5_suppl (2012): 448. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.448.

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448 Background: A new version of the TNM classification system for renal cell carcinoma (RCC) has been introduced in 2010 by the American Joint Committee on Cancer (AJCC). However, data for it’s ability to predict metastasis-free survival in RCC patients from validation studies of independent cohorts are sparse. Therefore, we decided to compare the predictive ability of the 2010 vs. the 2002 version of the TNM classification system. Methods: Pathological reports of 2595 patients with uni- or bilateral synchronous non-metastatic (pT1-4N0M0) RCCs, treated with radical nephrectomy or nephron spar

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Çalışkan, Selahattin, Orhan Koca, Mehmet Akyüz, Metin İshak Öztürk, and Muhammet Ihsan Karaman. "Changing the Stage, Grade and Histological Subtypes of Renal Cell Carcinomas during 10 Years Period." Prague Medical Report 118, no. 4 (2017): 119–27. http://dx.doi.org/10.14712/23362936.2017.13.

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Renal cell carcinomas (RCCs) account 80–85% of all primary renal neoplasms and originate from the renal cortex. The patients who underwent radical or partial nephrectomy for renal tumour in our unit between January 2005 and 2015 were evaluated retrospectively. The patients were divided into two groups; group 1 includes patients who were treated between January 2005 and December 2009, group 2 those from January 2010 to 2015. There were 103 patients in group 1. The patients were between 21 and 89 years with mean age of 61.46 year. Renal cell carcinomas account 83.4% of the patients, benign renal

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Zhang, Mei, Fei Feng, Zhilong Zhang, and Jinghua Wen. "A New Business Process Verification Approach for E-Commerce Using Petri Nets." International Journal of Enterprise Information Systems 16, no. 1 (2020): 92–107. http://dx.doi.org/10.4018/ijeis.2020010105.

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The design, modeling, optimization, reengineering, and coupling of business processes in e-commerce environment have gradually become a hot research topic. Business processes must be strictly described and validated by formal methods to ensure their reliability and efficiency. This paper systematically studies the introduction of new business process characteristics into behavioral temporal logic and extend TLA to obtain a new logic system PTLA, which enriches the theoretical system of formal method of business process under the environment of e-commerce. The paper also discusses Petri nets an

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Rambow-Larsen, Amy A., and Alison A. Weiss. "The PtlE Protein of Bordetella pertussis Has Peptidoglycanase Activity Required for Ptl-Mediated Pertussis Toxin Secretion." Journal of Bacteriology 184, no. 11 (2002): 2863–69. http://dx.doi.org/10.1128/jb.184.11.2863-2869.2002.

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ABSTRACT Pertussis toxin of Bordetella pertussis is secreted by a type IV secretion system comprised of the products of the nine ptl (pertussis toxin liberation) genes. These proteins are believed to form a complex spanning both the inner and outer membranes and passing through the peptidoglycan layer. Peptidoglycan acts as a barrier for transport through the periplasm of large folded molecules. Assembled pertussis toxin and the secretion component proteins PtlC through PtlH are too large to diffuse through intact peptidoglycan. Therefore, we hypothesized that the Ptl system contains a peptido

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Srivastava, Arnav, Hiten Patel, Max Kates, et al. "2542." Journal of Clinical and Translational Science 1, S1 (2017): 83. http://dx.doi.org/10.1017/cts.2017.293.

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OBJECTIVES/SPECIFIC AIMS: Due to increased experience and favorable outcomes, the use of partial nephrectomy (PN) to treat renal cell carcinoma has grown in the past decade, with expansion to larger tumors. Performing PN for larger tumors could potentially increase the number of patients up-staged to pT3a after surgery, who may have instead been treated with radical nephrectomy (RN), if known preoperatively. We aimed to estimate the proportion of patients up-staged to T3a disease after PN stratified by size. We also compared size-stratified survival outcomes of up-staged patients to those with

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Karki, S., P. Upadhyaya, M. Agarwal, KK Maharjan, and P. Lavaju. "Retinoblastoma: An institutional experience." Journal of Pathology of Nepal 5, no. 9 (2015): 723–26. http://dx.doi.org/10.3126/jpn.v5i9.13780.

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Background: This article aims to describe histopathologic high risk tumor characteristics in our patient population of retinoblastoma. It is based on consensus criteria for definitions of choroidal and optic nerve invasion as outlined in The International RetinoblastomaStaging Working Group (IRSWG) 2009.Materials and Methods: Fifty histopathologically diagnosed cases of retinoblastoma were archived from records of Pathology department during years 2004 to 2014. Re-evaluation of slides to identify choroidal and optic nerve invasion as per IRSWG along with Pathologic tumor staging was done. Data

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Srivastava, Arnav, Hiten Patel, Max Kates, et al. "Incidence of T3a upstaging and survival after partial nephrectomy: Size-stratified rates and implications for prognosis." Journal of Clinical Oncology 35, no. 15_suppl (2017): 4588. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.4588.

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4588 Background: The use of partial nephrectomy (PN) to treat renal cell carcinoma has grown in the past decade, with expansion to larger tumors. Performing PN for larger tumors may increase the number of patients up-staged to pT3a after surgery, who may have underwent radical nephrectomy (RN), if known preoperatively. We aimed to estimate the proportion of patients up-staged to T3a disease after PN, stratified by size. We also compared size-stratified survival of up-staged pT3a patients to those with T1a, T1b, or T2 disease. Methods: From 1998 – 2013, we identified patients undergoing PN or R

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Kawata, Nozomu, Kenya Yamaguchi, Tomohiro Igarashi, and Satoru Takahashi. "TIMP-1 as well as Microvessel Invasion and High Nuclear Grade Is a Significant Determinant Factor for Extension of Tumor Diameter in Localized RCC." Journal of Oncology 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/5035127.

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Objectives. To clarify what kind of pathological factor is necessary for the extension of tumor diameter in localized RCC, we studied localized RCC patients.Methods. We retrospectively reviewed medical records of 237 RCC patients in our institute who underwent nephrectomy. We performed immune histological analysis of MMP-2, MMP-9, TIMP-1, TIMP-2, and MT-MMP-1 for all samples.Results. Among the clinicopathological factors, multivariate analysis revealed nuclear grade; TIMP-2 and MT-MMP-1 were independent prognostic factors of localized RCC (risk ratio 1.50,p=0.037, risk ratio 1.12,p=0.008, and

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Xiang, Sheng, Li Wang, Cong-Cong Huang, et al. "Concave cubic PtLa alloy nanocrystals with high-index facets: Controllable synthesis in deep eutectic solvents and their superior electrocatalytic properties for ethanol oxidation." Journal of Power Sources 399 (September 2018): 422–28. http://dx.doi.org/10.1016/j.jpowsour.2018.07.102.

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Gallan, Alexander J., and Tatjana Antic. "Clinicopathologic Features of Small Renal Masses Associated With Distant Metastatic Disease." American Journal of Clinical Pathology 153, no. 5 (2019): 613–17. http://dx.doi.org/10.1093/ajcp/aqz202.

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Abstract Objectives To assess the clinicopathologic features of small renal masses (≤4 cm) associated with distant metastatic disease. Methods We identified radical or partial nephrectomies with renal cell carcinomas (RCCs) measuring 4 cm or less in size (pT1a or pT3a) from 2005 to 2015. Clinicopathologic features were compiled. Results A total of 590 RCCs 4 cm or less were identified, of which 3.9% were associated with distant metastatic RCC. Metastasis was more common in pT3a tumors 4 cm or less than pT1a tumors (19% vs 2.7%; P &lt; .01). Seventy percent of tumors were clear cell RCCs. O

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Bach, Horacio, Dennis Wong, and Yossef Av-Gay. "Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA." Biochemical Journal 420, no. 2 (2009): 155–62. http://dx.doi.org/10.1042/bj20090478.

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In Mycobacterium tuberculosis, signal transduction is mediated by 11 serine/threonine kinases, but no tyrosine kinases have been identified thus far. The protein encoded by the ORF (open reading frame) Rv2232 has been annotated as a member of the HAD (haloacid dehydrogenase-like hydrolase) superfamily, which includes phosphatases, phosphomanno- and phosphogluco-mutases, and haloacid dehydrogenases. In the present paper, we report, on the basis of biochemical and mutational analyses, that the Rv2232-encoded protein, named protein tyrosine kinase A (PtkA) is a bona fide protein tyrosine kinase.

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Nahouraii, Lauren, Jordan Allen, Suzanne Merrill, Erik Lehman, Matthew Kaag, and Jay Raman. "Histologic Heterogeneity of Extirpated Renal Cell Carcinoma Specimens: Implications for Renal Mass Biopsy." Journal of Kidney Cancer and VHL 7, no. 3 (2020): 20–25. http://dx.doi.org/10.15586/jkcvhl.v7i3.134.

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Pathologic characteristics of extirpated renal cell carcinoma (RCC) specimens <7 cm were reviewed to get better information on technical nuances of renal mass biopsy (RMB). Specimens were stratified according to tumor stage, nuclear grade, size, histology, presence of lymphovas-cular invasion (LVI), necrosis, and sarcomatoid features. When considering pT1 (0–7 cm) tumors pT1b (4–7 cm), RCC masses were more likely to have necrosis (43% vs 16%, P < 0.001), LVI (6% vs 2%, P = 0.024), high-grade nuclear elements (29% vs 17%, P < 0.001), and sarcomatoid features (2% vs 0%, P = 0.006) compa

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Brookman-May, Sabine Doris, Matthias May, Richard Zigeuner, et al. "Prognostic significance of perirenal fat invasion and tumor size in pT1 to pT3a renal cell carcinoma: Results of a comprehensive multicenter study of the CORONA project—Can we improve prognostic discrimination of patients with stage pT3a tumors?" Journal of Clinical Oncology 33, no. 7_suppl (2015): 416. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.416.

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416 Background: The renal cell carcinoma (RCC) TNM system merges perirenal fat invasion (PFI) and renal vein invasion (RVI) as stage pT3a despite limited evidence concerning their prognostic equivalence. Additionally, the prognostic value of PFI compared to pT1-pT2 tumors remains controversial. Methods: Data of 7,595 pT1a-pT3a RCC patients undergoing radical nephrectomy or nephron-sparin surgery were pooled from 12 European and U.S. centers (1999-2010). Patients were grouped according to stages and presence of PFI/RVI, i.e., pT1-2N0M0 (n=6,137; 80.8%), pT3aN0M0+PFI (n=1,036; 13.6%), and pT3aN0

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Matsumoto, Hiroaki, Kazuhiro Nagao, Masahiro Samoto, et al. "Relation between clinicopathological findings and PD-1 or PD-L1 status in non-clear cell renal cell carcinoma by a multicenter study." Journal of Clinical Oncology 37, no. 7_suppl (2019): 654. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.654.

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654 Background: We investigated correlation of their pathological findings and their prognostic factors in non-clear cell renal cell carcinoma (ncRCC) diagnosed by both regional pathology (RP) and central pathology (CP) in multicenter study. Methods: In January 2005 to December 2014, 140 cases of ncRCC diagnosed by radical or partial nephrectomy were assessed. We assessed their pathological diagnosis by one central pathologist using the 2016 WHO classification tumor of the kidney. We assessed the correlation between clinical parameters or pathological findings and their prognosis. Then, we per

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Tai, Huai-Ching, Ming-Kuen Lai, Chao-Yuan Huang, et al. "Oncologic Outcomes of Asian Men with Clinically Localized Prostate Cancer after Extraperitoneal Laparoscopic Radical Prostatectomy: A Single-Institution Experience." Prostate Cancer 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/748616.

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Purpose. To evaluate the midterm oncologic results of extraperitoneal laparoscopic radical prostatectomy (EPLRP) for Asian men with localized prostate cancer.Methods. Between 2004 and 2009, 218 men underwent EPLRP at an Asian tertiary hospital. The mean preoperative prostate-specific antigen (PSA) was 15.5 ng/ml and mean Gleason score was 6.6. Stage distributions were cT1a-b in 21 cases, cT1c in 139, cT2 in 48 and cT3 in 10. Disease recurrence was defined as PSA ≥ 0.2 ng/mL in 2 consecutive measurements or initiation of secondary therapy.Results. Postoperative pathological stage was pT2a-b in

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Farizo, Karen M., Thomas G. Cafarella, and Drusilla L. Burns. "Evidence for a Ninth Gene,ptlI, in the Locus Encoding the Pertussis Toxin Secretion System ofBordetella pertussisand Formation of a PtlI-PtlF Complex." Journal of Biological Chemistry 271, no. 49 (1996): 31643–49. http://dx.doi.org/10.1074/jbc.271.49.31643.

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Bostrom, Peter J., Tuomas Mirtti, Martti Nurmi, et al. "Extended lymphadenectomy and adjuvant chemotherapy in muscle-invasive bladder cancer treated by radical cystectomy." Journal of Clinical Oncology 30, no. 5_suppl (2012): 287. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.287.

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287 Background: Level 1 evidence is weak for adjuvant chemotherapy (AC) after cystectomy, but surveys indicate physicians refer patients for AC more frequently than for neoadjuvant chemotherapy (NC). The exact benefit of an extended pelvic lymph node dissection (ePLND) remains debated. We addressed the issue of AC and ePLND analyzing two academic centers RC databases with opposite approaches, one using ePLND and AC, the other performing a limited lymph node dissection and no AC. Methods: Two ethics approved RC databases including consecutive BC patients undergoing RC at the University Health N

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Schrag, Janelle, Ellen Kendall, Monique D. Dawkins, Leigh Boehmer, and Brian Koffman. "Using Data Visualization to Support the Need for Chronic Lymphocytic Leukemia Provider Education." Blood 134, Supplement_1 (2019): 5827. http://dx.doi.org/10.1182/blood-2019-128710.

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Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Due to its less common occurrence and slow progression, however, community-based oncology providers are less likely to regularly diagnose and treat patients with CLL. In addition, these providers may have unique difficulties in treating patients with CLL due to limited access to clinical trials, innovative therapies, and/or local/regional experts for referral or consults. Given these barriers, the Association of Community Cancer Centers (ACCC) developed educational resources to support community-based providers treating

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Cahn, David B., Elizabeth Handorf, Daniel C. Edwards, et al. "Treatment trends of localized renal cell carcinoma by hospital type: A NCDB analysis." Journal of Clinical Oncology 36, no. 6_suppl (2018): 641. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.641.

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641 Background: Weighing operative, oncologic and comorbid risks guide treatment recommendations for localized kidney cancers. We hypothesize that individualized surgical decision making may also be influenced by surgical center and volume. Methods: The National Cancer Database (NCDB) was queried for patients 18-80 years old with pT1a-T2bN0M0 RCC, treated by partial (PN) or radical nephrectomy (RN), or ablation (ABL) from 2004-2014. After adjusting for clinicopathologic characteristics, we evaluated the association of hospital volume (vol) and center classification with receipt of PN. High vol

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Hamilton, Zachary, Umberto Capitanio, Deepak K. Pruthi, et al. "Association of dividing pathologically upstaged T3a renal cell carcinoma with improved alignment of outcomes: A call for TMN revision." Journal of Clinical Oncology 36, no. 6_suppl (2018): 642. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.642.

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642 Background: Incidental pathological upstaging to pT3a disease can occur after surgical treatment of clinical T1 and T2 Renal Cell Carcinoma (RCC), and upstaged pT3a disease is associated with worsened outcomes. Oncologic and survival outcomes within the pT3a category are heterogeneous. We investigated recurrence and survival outcomes in pT3a disease, and aimed to better categorize this cohort for improvement on current TMN staging. Methods: Multi-center retrospective analysis of patients with renal cell carcinoma (cT1-3aN0M0) from 1987-2016. After initial comparison of outcomes between pT1

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Vakiani, Efsevia, Katia Basso, Ulf Klein, Riccardo Dalla-Favera, Laura Pasqualucci, and Govind Bhagat. "Gene Expression Analysis of B-Cell Post Transplant Lymphoproliferative Disorders Provides Insights into Disease Biology." Blood 110, no. 11 (2007): 3172. http://dx.doi.org/10.1182/blood.v110.11.3172.3172.

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Abstract Background: B-cell post transplant lymphoproliferative disorders (PTLDs) encompass a diverse group of entities, the majority representing EBV-driven lymphoproliferations, which arise in the setting of iatrogenic immunosuppression. Their pathogenesis, especially the genetic relationship of PTLD with other types of B-cell non-Hodgkin lymphomas (B-NHLs), is not well understood and the association of polymorphic PTLD (P-PTLD) with monomorphic PTLD (M-PTLD) is presently unclear. Thus, in order to address these issues we analyzed gene expression profiles of PTLD and compared them with those

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Semakula;, Barbara, Jon V. Rittenbach, and Jun Wang. "Hodgkin Lymphoma–like Posttransplantation Lymphoproliferative Disorder." Archives of Pathology & Laboratory Medicine 130, no. 4 (2006): 558–60. http://dx.doi.org/10.5858/2006-130-558-hlpld.

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Abstract Posttransplantation lymphoproliferative disorders (PTLD) are a heterogeneous group of monoclonal or polyclonal lymphoproliferative lesions that occur in immunosuppressed recipients following solid organ or bone marrow transplantation, including 4 categories: (1) early lesions (reactive plasmacytic hyperplasia, and infectious-mononucleosis–like PTLD), (2) polymorphic PTLD, (3) monomorphic PTLD (including B-cell neoplasms and T-cell neoplasms), and (4) Hodgkin lymphoma (HL) and HL-like PTLD in the current World Health Organization classification. Although HL-like PTLD has been grouped w

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Antonelli, A., D. Zani, M. Nicolai, et al. "Nephron-sparing surgery versus radical nephrectomy in the treatment of renal cell carcinoma up to 7 cm." Urologia Journal 74, no. 3 (2007): 173–79. http://dx.doi.org/10.1177/039156030707400309.

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Purpose To compare the oncological outcome of nephron-sparing surgery versus radical nephrectomy in renal cell carcinoma up to 7 cm by retrospectively reviewing our surgical experience. Materials and Methods Data collected from 1290 consecutive patients, who underwent surgery for renal carcinoma, have been stored since 1983 into a dedicated database. The cases with unilateral carcinoma up to 7 cm, pT1a/pT1b/pT3a N0/Nx M0, followed up for a minimum of 12 months if disease-free were reviewed. Results 732 patients were selected (mean follow-up: 72 months); 329 had a tumor less than 4 cm in diamet

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Haider, Mobeen Zaka, Zarlakhta Zamani, Fnu Kiran, et al. "A systematic review of post-transplant lymphoproliferative disorder after lung transplant." Journal of Clinical Oncology 39, no. 15_suppl (2021): e19046-e19046. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e19046.

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e19046 Background: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after solid organ transplantation. This study aims to explore the association of PTLD diagnosed after lung transplant with infectious agents and immunosuppression regimen, explore types of PTLD, and their outcome. Methods: Following the PRISMA guideline, we searched the literature on PubMed, Cochrane, Embase, and clinicaltrials.gov. 1741 articles were screened and included five studies. Results: We analyzed data from five studies, n=13,643 transplant recipients with n=287 (2.10%) developed PTLD. Fo

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Capello, Daniela, Giuliana Muti, Michaela Cerri, et al. "Molecular Analysis of Posttransplant Lymphoproliferative Disorders (PTLD) of Donor Origin Occuring in Liver Transplant Patients." Blood 106, no. 11 (2005): 1916. http://dx.doi.org/10.1182/blood.v106.11.1916.1916.

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Abstract Most PTLD occurring in solid organ patients arise from recipient cells, whereas few cases derive from donor transplanted lymphocytes. Donor-derived PTLD usually have a predilection for the allograft and are particularly frequent following liver transplant. To clarify the histogenesis and pathogenesis of donor-derived PTLD, we investigated 11 monoclonal PTLD occurring in liver transplant patients, including 6 cases arising from donor cells and 5 cases from recipient cells. Phenotypic markers of histogenesis included expression of BCL6, MUM1 and CD138, which segregate the germinal cente

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Gregori, A., A. Simonato, A. Lissiani, et al. "Perioperative Complications of Laparoscopic Radical Prostatectomy: Initial Experience." Urologia Journal 70, no. 1-4 (2003): 17–21. http://dx.doi.org/10.1177/039156030307001-403.

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We retrospectively evaluated the intraoperative and early postoperative complications of the initial experience with the first 80 laparoscopic radical prostatectomies performed at our institution. Between January 17, 2001 and July 24, 2002, 80 patients with clinically localized prostate cancer underwent transperitoneal laparoscopic radical prostatectomy. The pathological tumor stage revealed 18 pT2a (22.5%), 29 pT2b (36.25%), 21 pT3a (26.25%), 10 pT3b (12.5%), 1 pT4 (1.25%), 1 pT4 N1 (1.25%). No conversion was necessary in all cases. Injury to the epigastric vessels was detected intraoperative

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Stubbins, Ryan J., Anthea C. Peters, Mabilang Curtis, et al. "Morphologic Evolution in Post-Transplant Lymphoproliferative Disorders (PTLD): A Clinicopathologic Case Series." Blood 126, no. 23 (2015): 5008. http://dx.doi.org/10.1182/blood.v126.23.5008.5008.

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Abstract Post-transplant lymphoproliferative disorders (PTLDs) are classified as early PTLDs (E-PTLD), polymorphic PTLDs (P-PTLD), monomorphic PTLDs (M-PTLD) and classical Hodgkin's Lymphoma PTLD (HL). These entities are felt to represent a disease continuum, with a precursor-product relationship, though they are morphologically and clinically distinct. However, this process remains poorly understood, and limited evidence exists to support this hypothesis. We report a series of nine cases extracted from a PTLD database, including both pediatric and adult solid organ transplant recipients, with

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Maecker-Kolhoff, B., and C. Klein. "Das pädiatrische PTLD-Register (Ped-PTLD-Register)." Der Nephrologe 4, no. 4 (2009): 339–44. http://dx.doi.org/10.1007/s11560-009-0306-8.

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Kalra, Amit, Cameron Roessner, Jennifer Jupp, Andrew Daly, and Jan Storek. "Limited Efficacy of Prompt Therapy of Posttransplant Lymphoproliferative Disorder (PTLD) with Rituximab." Blood 126, no. 23 (2015): 3114. http://dx.doi.org/10.1182/blood.v126.23.3114.3114.

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Abstract Introduction: Epstein-Barr virus (EBV)-induced posttransplant lymphoproliferative disorder (PTLD) incidence is particularly high when using graft versus host disease (GVHD) prophylaxis with rabbit antithymocyte globulin (ATG). Preemptive therapy with rituximab given when EBV DNAemia exceeds a threshold has been adopted by some centers. However, this exposes a large fraction of patients to rituximab, which is costly and toxic (neutropenia). Wagner et al suggested a high efficacy of prompt therapy (monitoring EBV DNAemia, having a high index of suspicion for PTLD in patients with high D

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Rossi, Davide, Clara Deambrogi, Monia Lunghi, et al. "Aberrant Methylation of SHP-1 (SH2-Containing Phosphatases 1) and SOCS-1 (Suppressor of Cytokine Signalling 1) Genes in Immunodeficiency-Related Lymphomas." Blood 108, no. 11 (2006): 2386. http://dx.doi.org/10.1182/blood.v108.11.2386.2386.

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Abstract SHP-1 and SOCS-1 are members of a family of negative regulators of signaling that act downstream of cytokine receptors, receptor tyrosine kinases and receptor complexes of the immune and hemopoietic system. SHP-1 and SOCS-1 act through the inhibition of the JAK2/STAT pathway and their inactivation is considered to be a relevant mechanism in JAK2/STAT pathway induction. Several observations point to induction of the JAK/STAT pathway as an important mechanism of lymphomagenesis. Since DNA methylation is a mechanism of gene silencing involved in the pathogenesis of human cancers, includi

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Cook, David M., Karen M. Farizo, and Drusilla L. Burns. "Identification and Characterization of PtlC, an Essential Component of the Pertussis Toxin Secretion System." Infection and Immunity 67, no. 2 (1999): 754–59. http://dx.doi.org/10.1128/iai.67.2.754-759.1999.

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ABSTRACT PtlC is a member of a set of proteins necessary for the secretion of pertussis toxin (PT) from Bordetella pertussis. Using polyclonal antibodies specific for PtlC, we identified PtlC as a protein with an apparent molecular weight of 85,000 that localizes to the membrane fraction of bacterial cell extracts. We found that a mutant strain of B. pertussis that contains an in-frame deletion in ptlC is unable to secrete PT and that PT secretion is fully restored by expressing ptlC intrans, indicating that PtlC is essential for transport of PT across the bacterial membrane(s). PT secretion w

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Yui, Tatsuto, Tatsuya Kameyama, Takayosi Sasaki, Tsukasa Torimoto, and Katsuhiko Takagi. "Pyrene-to-porphyrin excited singlet energy transfer in LBL-deposited LDH nanosheets." Journal of Porphyrins and Phthalocyanines 11, no. 06 (2007): 428–33. http://dx.doi.org/10.1142/s1088424607000485.

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Nano-ordered hybrid films of layered double hydroxide (LDH) nanosheets and two types of anionic dye molecules, i.e. tetrakis(4-carboxyphenyl)porphyrin (TCPP) and 1,3,6,8-pyrenetetrasulfonic acid (PTSA), were prepared by a layer-by-layer deposition (LBL) method. Photo-induced energy transfers (PET) between the PTSA and TCPP layers were investigated for two differently stacked structures of the TCPP/LDH/PTSA hybrid films, i.e. (a) PTSA/LDH multilayers independently stacked on the TCPP/LDH multilayers to form (TCPP/LDH)n/(PTSA/LDH)n and (b) TCPP/LDH and PTSA/LDH monolayers deposited alternately t

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Reddy, Madhumitha, Ahmet Bindayi, Zachary Hamilton, et al. "Oncologic and functional outcomes of radical and partial nephrecotmy in PT3A patholigically upstaged renal cell carcinoma: A multi-instituitional analysis." Journal of Clinical Oncology 36, no. 6_suppl (2018): 685. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.685.

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685 Background: Radical Nephrectomy (RN) has been the standard of care for complex and locally advanced renal cell carcinoma (RCC). Efficacy of PN in the setting of pT3a pathologic upstaged disease is controversial. We compared oncologic and functional outcomes of RN and PN in patients with upstaged pT3a RCC. Methods: Multicenter retrospective analysis of patients with cT1−2N0M0 RCC undergoing RN or PN upstaged to pT3a postoperatively. Primary outcome was Overall Survival (OS), with secondary outcomes being Recurrence Free Survival (RFS) and eGFR < 60 at last follow-up. Results: 8185 patien

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Haider, Mobeen Zaka, Zarlakhta Zamani, Hasan Mehmood Mirza, et al. "A systematic review of post-transplant lymphoproliferative disorder after liver transplant." Journal of Clinical Oncology 39, no. 15_suppl (2021): e19045-e19045. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e19045.

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e19045 Background: Post-transplant lymphoproliferative disorder (PTLD) is a complication after liver transplantation. This study aims to explore the association of PTLD with the immunosuppression, types of PTLD, clinical presentation, and outcomes. Methods: Following the PRISMA guideline, we searched the literature on PubMed, Cochrane, Embase, and clinicaltrials.gov. 1741 articles were screened and 22 studies were included. Results: Data includes 22,235 total patients who underwent a liver transplant, and 449 (2.0%) patients who developed PTLD were studied. Of the 394 patients where gender was

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Muchtar, Eli, Liat Vidal, Ron Ram, et al. "Post-Transplant Lymphoproliferative Disorder in Lung Transplant Recipients – a Shift Lo Late Onset Disease." Blood 120, no. 21 (2012): 5075. http://dx.doi.org/10.1182/blood.v120.21.5075.5075.

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Abstract Abstract 5075 Background: Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication after solid organ transplantation. Most cases of PTLD arise within the first year from transplantation and are associated with EBV infection. However, there are increasing reports on a late onset form of PTLD. Methods: We reviewed all charts of patients undergoing either lung or heart-lung transplantation in a tertiary center in Israel between the years 1997 and 2012. PTLD was defined according to the WHO criteria. We analyzed baseline characteristics, clinical and pathologi

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Miranda Jr., Fausto, Maria del Carmen Janeiro Perez, Frida Plavnik, João Francisco Jr., and Emil Burihan. "Percutaneous transluminal angioplasty in the treatment of renovascular hypertension: sequential prospective study." Sao Paulo Medical Journal 116, no. 1 (1998): 1613–17. http://dx.doi.org/10.1590/s1516-31801998000100004.

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OBJECTIVE: to evaluate the use of percutaneous transluminal renal angioplasty (PTRA) in the treatment of renal vascular hypertension. DESIGN: sequential prospective PTRA treatment of severe arterial hypertension, screening by the captopril test, confirmed by renal arteriography, and the result evaluated by post-PTRA arteriography, blood pressure measurement and renal function. SITE: Vascular Surgery, angioradiology sector, and Nephrology outpatients department of the Federal University of São Paulo - Paulista School of Medicine, São Paulo, Brazil, a tertiary health-care institution. PARTICIPAN

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Trendafilova, Natasha, Ivelina Georgieva, and George St Nikolov. "Platinum (II) Compounds With Antitumor Activity Studied by Molecular Mechanics." Metal-Based Drugs 5, no. 2 (1998): 91–102. http://dx.doi.org/10.1155/mbd.1998.91.

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A series of Pt(ll) complexes with antitumor properties: [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]PtL2 (meso-1-PtL2) and [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]PtL2, [2L=2Cl−,2I−,SO42−; halo = F (erythro-8-PtL2), halo = Cl (erythro-9-PtL2)] has been modelled by molecular mechanics (MM). The MM calculations were carried out for different isomers and ligand conformations meso-δ, meso-λ, d,l-δ, d,I-λ. The compounds with the lowest MM energies have the same geometries as those obtained by X-ray analysis. The calculated MMX energy orders: mes

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Mukhtar, Mariam S., and Stephen L. Wolman. "Post-transplant lymphoproliferative disorder as a cause of oesophageal ulceration and stricture: case report and literature review." BMJ Open Gastroenterology 8, no. 1 (2021): e000602. http://dx.doi.org/10.1136/bmjgast-2021-000602.

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Post-transplant lymphoproliferative disorder (PTLD) of the oesophagus is a rare complication of solid organ transplant that requires a high index of suspicion to diagnose. A literature review conducted on Ovid Medline database retrieved 24 articles, among which five previous cases of oesophageal PTLD were identified. Development of oesophageal strictures related to PTLD has not been reported in the literature. We report a case of oesophageal PTLD following lung transplant, presenting with extensive, circumferential ulceration in the oesophagus. PTLD was successfully treated with chemotherapy b

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Luan, Chih-Wei, Chih-Cheng Chen, Kam-Fai Lee, et al. "Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder." Healthcare 9, no. 2 (2021): 217. http://dx.doi.org/10.3390/healthcare9020217.

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(1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of PTLD after bone marrow transplantation, are uncommon. (2) Case presentation: We report the case of a 40-year-old woman with myelodysplastic disorder who underwent hematopoietic stem cell transplantation (HSCT). After 3 months, she developed low-grade fever, progressive nasal obstruction, and bloody

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Rojas Vasquez, Marta, Anthea Peters, Raymond Lai, Curtis Mabilangan, Burton Catherine, and Jutta Preiksaitis. "Epidemiology of Post-Transplant Lymphoproliferative Disorders in Children with Solid Organ Transplant over 34 Years of a Single Center Experience." Blood 134, Supplement_1 (2019): 1602. http://dx.doi.org/10.1182/blood-2019-125344.

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Background Post-Transplant lymphoproliferative disorders (PTLD) are a heterogeneous group of lymphoid neoplasms following solid organ transplantation (SOT) caused by uncontrolled lymphoproliferation often induced by Epstein Barr Virus (EBV) due to the lack of cytotoxic T cell response resulting from immunosuppression. A pre-emptive intervention strategy for PTLD prevention was implemented in our center in 2002 for all EBV-mismatched SOT recipients consisting in close monitoring of the viral load and consideration for early intervention (Ex; reduction of immunosuppression) in addition to univer

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Osawa, Hideki, Mamoru Uemura, Junichi Nishimura, et al. "Surgical Management of Perforated Gastrointestinal Posttransplantation Lymphoproliferative Disorder After Heart Transplantation." International Surgery 100, no. 2 (2015): 358–64. http://dx.doi.org/10.9738/intsurg-d-13-00270.1.

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Posttransplantation lymphoproliferative disorder (PTLD) is a relatively rare and life-threatening complication after organ transplantation. From 1999 to 2012, 45 adult patients underwent heart transplantation at our hospital. Two of the patients developed PTLD after transplantation and required emergency surgery due to intestinal perforation. These cases were informative regarding the adequate surgical management of such cases. Both cases revealed Epstein-Barr virus-related PTLD. The optimal treatment of PTLD remains controversial, and PTLD with gastrointestinal perforation could be critical b

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