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Thematische Bibliographien / Radiation therapy / Dissertationen

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Dissertationen zum Thema „Radiation therapy“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 25. Juli 2025

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1

Crosbie, Jeffrey. "Synchrotron microbeam radiation therapy." Monash University. Faculty of Science. School of Physics, 2008. http://arrow.monash.edu.au/hdl/1959.1/64948.

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This thesis presents interdisciplinary, collaborative research in the field of synchrotron microbeam radiation therapy (MRT). Synchrotron MRT is an experimental radiotherapy technique under consideration for clinical use, following demonstration of efficacy in tumour-bearing rodent models with remarkable sparing of normal tissue. A high flux, X-ray beam from a synchrotron is segmented into micro-planar arrays of narrow beams, typically 25 μm wide and with peak-to-peak separations of 200 μm. The radiobiological effect of MRT and the underlying cellular mechanisms are poorly understood. The

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Skiöld, Sara. "Radiation induced biomarkers of individual sensitivity to radiation therapy." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-97123.

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Fifty percent of solid cancers are treated with radiation therapy (RT). The dose used in RT is adjusted to the most sensitive individuals so that not more than 5% of the patients will have severe adverse healthy tissue effects. As a consequence, the majority of the patients will receive a suboptimal dose, as they would have tolerated a higher total dose and received a better tumor control. Thus, if RT could be individualized based on radiation sensitivity (RS), more patients would be cured and the most severe adverse reactions could be avoided. At present the mechanisms behind RS are not known

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3

Bergh, Alphonsus Cornelis Maria van den. "Radiation therapy in pituitary adenomas." [S.l. : [Groningen : s.n.] ; University of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.

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4

Flejmer, Anna M. "Radiation burden from modern radiation therapy techniques including proton therapy for breast cancer treatment - clinical implications." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127370.

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The purpose of this thesis was to study the clinical implications of modern radiotherapy techniques for breast cancer treatment. This was investigated in several individual studies. Study I investigated the implications of using the analytical anisotropic algorithm (AAA) from the perspective of clinical recommendations for breast cancer radiotherapy. Pencil beam convolution plans of 40 breast cancer patients were recalculated with AAA. The latter plans had a significantly worse coverage of the planning target volume (PTV) with the 93% isodose, higher maximum dose in hotspots, higher volumes of

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Fitzgerald, Rhys J. "A comparison of volumetric modulated arc therapy (VMAT), intensity modulated radiation therapy (IMRT) and 3-dimensional conformal radiation therapy (3DCRT) for stereotactic ablative radiation therapy (SABR) for early stage lung cancer." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/99826/4/Rhys_Fitzgerald_Thesis.pdf.

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This thesis is a comparative study looking at different radiation therapy treatment techniques for treating early stage lung cancer. It investigated three different techniques that had differing number of beams and treatment angles. Furthermore, it also look at beams that rotated, against beams that were stationary. It was discovered that multiple beams that continuously rotate around the patient provided optimal dose to the tumour, minimum dose to surrounding healthy tissues and had the quickest delivery time.

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Engelbeen, Céline. "The segmentation problem in radiation therapy." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210107.

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The segmentation problem arises in the elaboration of a radiation therapy plan. After the cancer has been diagnosed and the radiation therapy sessions have been prescribed, the physician has to locate the tumor as well as the organs situated in the radiation field, called the organs at risk. The physician also has to determine the different dosage he wants to deliver in each of them and has to define a lower bound on the dosage for the tumor (which represents the minimum amount of radiation that is needed to have a sufficient control of the tumor) and an upper bound for each organ at risk (whi

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7

Chan, Kin Wa (Karl), University of Western Sydney, of Science Technology and Environment College, and School of Computing and Information Technology. "Lateral electron disequilibrium in radiation therapy." THESIS_CSTE_CIT_Chan_K.xml, 2002. http://handle.uws.edu.au:8081/1959.7/538.

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The radiation dose in radiation therapy is mainly measured by ion chamber. The ion chamber measurement will not be accurate if there is not enough phantom material surrounding the ion chamber to provide the electron equilibrium condition. The lack of electron equilibrium will cause a reduction of dose. This may introduce problems in treatment planning. Because some planning algorithms cannot predict the reduction, they over estimate the dose in the region. Electron disequilibrium will happen when the radiation field size is too small or the density of irradiated material is too low to provide

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Chan, Kin Wa. "Lateral electron disequilibrium in radiation therapy /." View thesis, 2002. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20040507.164802/index.html.

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Thesis (M.Sc.) (Hons)-- University of Western Sydney, 2002.<br>"A thesis submitted in fulfillment of the requirements for the Degree of Master of Science (Honours) in Physics at the University of Western Sydney" "September 2002" "Kin Wa (Karl) Chan of Medical Physics Department of Westmead Hospital and the University of Western Sydney"-- t.p. Bibliography: leaves 100-105.

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Ranggård, Nina. "Optimizing Conformity inIntensity Modulated Radiation Therapy." Thesis, KTH, Fysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-147356.

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10

Chan, Timothy Ching-Yee. "Optimization under uncertainty in radiation therapy." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40302.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Sloan School of Management, Operations Research Center, 2007.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references (p. 175-182).<br>In the context of patient care for life-threatening illnesses, the presence of uncertainty may compromise the quality of a treatment. In this thesis, we investigate robust approaches to managing uncertainty in radiation therapy treatments for cancer. In the first part of the

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11

Brauer-Krisch, E. "Experimental dosimetry for Microbeam Radiation Therapy." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1357933/.

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The thesis gives an overview on the preclinical results in Microbeam Radiation Therapy (MRT), a novel radiation therapy using microscopically small beams. In the first chapter preclinical results and biological observations after Microbeam Radiation Therapy are presented, in particular the normal tissue tolerance is highlighted. A chapter based on theoretical Monte Carlo dose calculations is summarizing a set of data on peak to valley dose ratios (PVDR) and relative dose distributions for various parameter settings, providing some guideline for preclinical studies. The main part of the thesis

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Balsells, Alex T. "Computational Methods for Radiation Therapy Planning." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1557844457085534.

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13

Dial, Christian W. "Adaptive Radiation Therapy for Lung Cancer." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3579.

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Prognosis for lung cancer patients remains poor. For those receiving radiation therapy, local control and survival have been shown to improve with increased doses; however, deliverable dose is often limited by associated toxicity. Therefore, methods that reduce dose to normal tissues and allow isotoxic escalation are desirable. Adaptive radiation therapy seeks to improve treatment by modifying the initial plan throughout delivery, and has been shown to decrease normal tissue dose. Studies to date suggest a trend of increasing benefit with increases in replanning frequency; however, replanning

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Scott, Susan Lynne Pipes. "Enhancing radiation therapy for prostate cancer /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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15

Mueller, Marco. "Direct tumour tracking during radiation therapy." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29450.

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Lung cancer stereotactic ablative body radiation therapy is one of the cancer treatment success stories. However, treatment outcomes and efficacy are limited by the fact that patients move, breathe, and their hearts beat, causing tumour and healthy tissue motion during imaging and radiation treatment. Direct tumour tracking is a novel method to visualise tumours during radiation therapy to improve treatment accuracy and healthy tissue sparing in the presence of internal anatomic motion. Direct tumour tracking is an affordable technology that is compatible with 95% of existing radiation t

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Fan, Qiyong. "Emission guided radiation therapy: a feasibility study." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37277.

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Accurate tumor tracking remains as a major challenge in radiation therapy. Large margins are added to the clinical target volume (CTV) to ensure the treatment of tumor in presence of patient setup uncertainty and that caused by intra-motion. Fiducial seeds and calypso markers are commonly implanted into the disease sites to further reduce the dose delivery error due to tumor motion. For more accurate dose delivery and improved patient comfort, the use of radioactive tracers in positron emission tomography (PET) as non-invasive tumor markers has been proposed - a concept called emission-guided

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Wong, Tony Po Yin, and tony wong@swedish org. "Improving Treatment Dose Accuracy in Radiation Therapy." RMIT University. Applied Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080104.144139.

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The thesis aims to improve treatment dose accuracy in brachytherapy using a high dose rate (HDR) Ir-192 stepping source and in external beam therapy using intensity modulated radiation therapy (IMRT). For HDR brachytherapy, this has been achieved by investigating dose errors in the near field and the transit dose of the HDR brachytherapy stepping source. For IMRT, this study investigates the volume effect of detectors in the dosimetry of small fields, and the clinical implementation and dosimetric verification of a 6MV photon beam for IMRT. For the study of dose errors in the near field o

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Chapman, Alison. "Dosimetric verification of intensity modulated radiation therapy." Access electronically, 2005. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20061026.141700/index.html.

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19

Fan, Qiyong. "Emission guided radiation therapy: a feasibility study." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52153.

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The effectiveness of cancer treatment is compromised by the need to reduce the uncertainties originating from a variety of factors including tumor volume delineation, patient setup, and irregular physiologic motion. In particular, effective yet practical tumor motion management remains a major challenge in current external beam radiation therapy. Many strategies such as motion encompassment, breath-hold techniques, and respiratory gating have been proposed in the literature and implemented clinically. These methods have shown success in certain situations with different limitations. With the a

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Cutter, David J. "Radiation-related cardiovascular disease following cancer therapy." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3f02ca87-530d-4ee7-9382-4b457bec62b5.

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<b><u>Introduction:</b></u> Some cancer survivors are known to have an elevated risk of morbidity and mortality from cardiovascular disease. An important cause of this elevated risk is recognised to be irradiation of normal tissues during radiotherapy received as part of cancer therapy. There are substantial difficulties in studying radiation-related cardiovascular disease (RRCD). The reasons for this include the complexities of measuring radiation normal tissue doses retrospectively and the prolonged latencies of many of the cardiovascular endpoints. A variety of complimentary research method

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Andersson, Björn. "Mathematical Optimization of Radiation Therapy Goal Fulfillment." Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325396.

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Cancer is one of the deadliest diseases today, and with increasingly larger and older populations, cancer constitutes an enormous contemporary and future challenge. Luckily, advances in technology and medicine are continuously contributing to a decrease in cancer mortality, and to the reduction of treatment side effects. The aim of this Master's thesis is to be a part of these advances, thereby increasing the survival chances and well-being of future cancer patients. The thesis regards specifically the improvement of radiation therapy, a form of treatment utilized in both curative and palliati

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Shin, Naomi. "Modeling secondary cancer risk following paediatric radiotherapy: a comparison of intensity modulated proton therapy and photon therapy." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106431.

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Proton radiotherapy is known to reduce the radiation dose delivered to normal healthy tissue compared to photon techniques. The increase in normal tissue sparing could result in fewer acute and late effects from radiation therapy. In this work proton therapy plans were created for patients previously treated using photon therapy. Intensity modulated proton therapy (IMPT) plans were planned using inverse planning in Varian's Eclipse treatment planning system with a scanning proton beam model to the same relative biological effectiveness (RBE)-weighted prescription dose as the photon plan. Prot

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23

Dou, Xin Wu Xiaodong. "New algorithms for target delineation and radiation delivery in intensity-modulated radiation therapy." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/354.

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24

Dou, Xin. "New algorithms for target delineation and radiation delivery in intensity-modulated radiation therapy." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/354.

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Intensity modulated radiation therapy (IMRT) is a modern cancer therapy technique that aims to deliver a highly conformal radiation dose to a target tumor while sparing the surrounding normal tissues. The prescribed dose is specified by an intensity map (IM) matrix and often delivered by a multileaf collimator (MLC). In this thesis, we study a set of combinatorial optimization problems arising in the field of IMRT: 1) the auto-contouring problems using region properties, which aim to optimize the intraclass variance of the target objects; 2) the field decomposition problems, whose goal is to d

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Bäck, Sven Å J. "Implementation of MRI gel dosimetry in radiation therapy." Malmö : Lund : Malmö University Hospital ; Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945079.html.

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26

Olofsson, Lennart. "Energy and intensity modulated radiation therapy with electrons." Doctoral thesis, Umeå : Department of Radiation Sciences, Radiation Physics, Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-491.

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27

Carlsson, Fredrik. "Utilizing Problem Structure in Optimization of Radiation Therapy." Doctoral thesis, Stockholm : Matematik, Kungliga Tekniska högskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4689.

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28

Testa, Mauro. "Charged particle therapy, ion range verification, prompt radiation." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00566188.

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This PhD thesis reports on the experimental investigation of the prompt photons created during the fragmentation of the carbon beam used in particle therapy. Two series of experiments have been performed at the GANIL and GSI facilities with 95 MeV/u and 305 MeV/u 12C6+ ion beams stopped in PMMA and water phantoms. In both experiments a clear correlation was obtained between the C-ion range and the prompt photon profile. A major issue of these measurements is the discrimination between the prompt photon signal (which is correlated with the ion path) and a vast neutron background uncorrelated wi

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Jain, Suneil. "Gold nanoparticles as novel sensitisers for radiation therapy." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534722.

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30

Ramakrishnan, Jagdish. "Dynamic optimization of fractionation schedules in radiation therapy." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82181.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2013.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (p. 145-156).<br>In this thesis, we investigate the improvement in treatment effectiveness when dynamically optimizing the fractionation scheme in radiation therapy. In the first part of the thesis, we consider delivering a different do

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Watkins, W. Tyler. "Optimization of Radiation Therapy in Time-Dependent Anatomy." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3069.

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The objective of this dissertation is to develop treatment planning techniques that have the potential to improve radiation therapy of time-dependent (4D) anatomy. Specifically, this study examines dose estimation, dose evaluation, and decision making in the context of optimizing lung cancer radiation therapy. Two methods of dose estimation are compared in patients with locally advanced and early stage lung cancer: dose computed on a single image (3D-dose) and deformably registered, accumulated dose (or 4D-dose). The results indicate that differences between 3D- and 4D- dose are not signi

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Zhou, Jining. "ORGAN MOTION AND IMAGE GUIDANCE IN RADIATION THERAPY." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1681.

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Organ motion and inaccurate patient positioning may compromise radiation therapy outcome. With the aid of image guidance, it is possible to allow for a more accurate organ motion and motion control study, which could lead to the reduction of irradiated healthy tissues and possible dose escalation to the target volume to achieve better treatment results. The studies on the organ motion and image guidance were divided into the following four sections. The first, the interfractional setup uncertainties from day-to-day treatment and intrafractional internal organ motion within the daily treatment

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Shao, Wei. "Improving functional avoidance radiation therapy by image registration." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/7031.

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Radiation therapy (RT) is commonly used to treat patients with lung cancer. One of the limitations of RT is that irradiation of the surrounding healthy lung tissues during RT may cause damage to the lungs. Radiation-induced pulmonary toxicity may be mitigated by minimizing doses to high-function lung tissues, which we refer to as functional avoidance RT. Lung function can be computed by image registration of treatment planning four-dimensional computed tomography (4DCT), which we refer to as CT ventilation imaging. However, the accuracy of functional avoidance RT is limited by lung function im

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Reynard, Dimitri. "Development of Accurate Dosimetry for Microbeam Radiation Therapy." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAS038/document.

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L’utilisation de petits champs dans les techniques de radiothérapie a considérablement augmenté, en particulier dans les traitements stéréotaxiques et les grands champs uniformes ou non uniformes qui sont composés de petits champs tels que la radiothérapie à modulation d’intensité (IMRT) ou la radiothérapie par microfaisceaux. Pour ces champs d’irradiation, les erreurs dosimétriques ont augmenté par rapport aux faisceaux conventionnels. La raison principale en est qu’il n’existe pas de protocole dosimétrique standard. Dans le cas de la MRT, un protocole dédié a été développé sur la base d’une

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Peet, Samuel. "Out-of-field dosimetry in contemporary radiation therapy." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/234916/1/9325565_samuel_peet_thesis.pdf.

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Radiation therapy is a beneficial treatment for approximately half of all people diagnosed with cancer. This project improved the safety of radiation therapy for several vulnerable cohorts: pregnant patients, patients with electronic implants such as pacemakers, and young people at risk of developing secondary cancers later in life. In doing so, this research furthered equitable access to safe, high-quality health care.

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Capuccini, Jenny <1976&gt. "Short course accelerated radiation therapy in palliative care." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8411/1/CAPUCCINI_JENNY_TESI.pdf.

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Palliative radiotherapy is a key resource for symptoms control and improvement patient's life expectancy in advanced stage of illness. The most common symptoms that afflict this type of patients are pain, bleeding, dysphagia, obstruction, vomiting, nausea. Most of these can benefit from a hypo-fractionated radiation treatment with a good percentage of complete responses, variable depending on the symptom considered, but on average 56-70%. Normally a hypo-fractionated treatment, excluding uncomplicated bone metastases where the single fraction (800 cGy in 1 fraction) is the standard, prov

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Anstett, Anne. "Approach of combined cancer gene therapy and radiation : Response of promoters to ionizing radiation." Université Louis Pasteur (Strasbourg) (1971-2008), 2005. https://publication-theses.unistra.fr/public/theses_doctorat/2005/ANSTETT_Anne_2005.pdf.

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La thérapie génique est un moyen de traitement du cancer. Cette étude s'intéresse au développement d'un système de thérapie génique induit par les radiations ionisantes (RI) dans le but de radiosensibiliser les cellules vasculaires. Un système d'expression basé sur l'utilisation de promoteurs induits par les irradiations va permettre l'expression de gènes anti-tumoraux dans le réseau vasculaire tumoral. Le développement des tumeurs solides est dépendant de l'angiogénèse, un processus dans lequel de nouveaux vaisseaux sanguins sont générés à partir d'une vascularisation pré-existante. De part l

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Nilsson, Johan. "Accurate description of heterogeneous tumors for biologically optimized radiation therapy." Doctoral thesis, Stockholm : Division of medical radiation physics, Department of oncology-pathology, Stockholm University and Karolinska Institutet, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-311.

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Tanny, Sean M. "Investigation of Radiation Protection Methodologies for Radiation Therapy Shielding Using Monte Carlo Simulation and Measurement." University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449853114.

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Tangboonduangjit, Puangpen. "Intensity-modulated radiation therapy dose maps the matchline effect /." Access electronically, 2006. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20060724.095712/index.html.

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Fredriksson, Albin. "Robust optimization of radiation therapy accounting for geometric uncertainty." Doctoral thesis, KTH, Optimeringslära och systemteori, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-122262.

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Geometric errors may compromise the quality of radiation therapy treatments. Optimization methods that account for errors can reduce their effects. The first paper of this thesis introduces minimax optimization to account for systematic range and setup errors in intensity-modulated proton therapy. The minimax method optimizes the worst case outcome of the errors within a given set. It is applied to three patient cases and shown to yield improved target coverage robustness and healthy structure sparing compared to conventional methods using margins, uniform beam doses, and density override. Inf

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Wiklund, Kristin. "Modeling of dose and sensitivity heterogeneities in radiation therapy." Doctoral thesis, Stockholms universitet, Fysikum, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-74719.

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The increased interest in the use of light ion therapy is due to the high dose conformity to the target and the dense energy deposition along the tracks resulting in increased relative biological effectiveness compared to conventional radiation therapy. In spite of the good clinical experience, fundamental research on the characteristics of the ion beams is still needed in order to be able to fully explore their use. Therefore, a Monte Carlo track structure code, KITrack, simulating the transport of electrons in liquid water, has been developed and used for calculation of parameters of interes

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Alrushoud, Abdullah A. "Polymer gel dosimetry in radiation therapy using computed tomography." Thesis, University of Surrey, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616921.

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There have been developments in radiation therapy treatment techiques, which lead to an increase in the complexity of these treatments. The aim is to deliver highly conformal three-dimensional (3D) dose distributions, such as stereotactic radiosurgery (SRS). Polymer gel dosimetry offers three-dimensional (3D) dosimetry techniques for dose verification of dose distributions. Nisopropyl- acrylamide (NIP AM) polymer gel was the latest to develop and can be prepared under a normal atmospheric environment and has lower toxicity compared with the highly toxic polymer gels used earlier. NIPAM polymer

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Olsson, Henrik. "Utilizing the Degrees of Freedom in Radiation Therapy Optimization." Thesis, KTH, Optimeringslära och systemteori, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-214566.

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The development of advanced software for radiation therapy treatment has had a significant role in the last decades’ improvements in cancer treatment. By optimizing the radiation dose given to each patient, the probability of a successful treatment increases. The development of mathematical optimization methods, required to produce as good radiation therapy treatment plans as possible, is therefore of high importance. When producing treatment plans for Volumetric Modulated Arc Therapy (VMAT) today, there are degrees of freedom that are not fully utilized. The possibility of rotating the patien

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Schneider, Tim. "Advancing the generation of proton minibeams for radiation therapy." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASP069.

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Malgré d’importants progrès, la tolérance des tissus sains aux rayonnements demeure un facteur central en radiothérapie, limitant par exemple l’efficacité du traitement des gliomes de haute grade. La proton thérapie avec mini-faisceaux (proton minibeam radiation therapy, pMBRT) est une nouvelle stratégie thérapeutique qui a pour objectif d’améliorer la préservation des tissus sains en combinant les avantages balistiques des protons et le fractionnement spatial de la dose obtenu avec des faisceaux submillimétriques. Dans ce contexte, la pMBRT a déjà démontré sa capacité à augmenter l’index thér

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Zachariah, Elizabeth. "Spatio-Temporal Modeling Of Anatomic Motion For Radiation Therapy." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3972.

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In radiation therapy, it is imperative to deliver high doses of radiation to the tumor while reducing radiation to the healthy tissue. Respiratory motion is the most significant source of errors during treatment. Therefore, it is essential to accurately model respiratory motion for precise and effective radiation delivery. Many approaches exist to account for respiratory motion, such as controlled breath hold and respiratory gating, and they have been relatively successful. They still present many drawbacks. Thus, research has been expanded to tumor tracking. The overall goal of 4D-CT is to pr

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Polston, Gregory K. "A dosimetric model for small-field electron radiation therapy." Muncie, Ind. : Ball State University, 2008. http://cardinalscholar.bsu.edu/366.

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Kumar, Arvind. "Novel methods for intensity modulated radiation therapy treatment planning." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0011543.

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Zhang, Tianfang. "Machine learning multicriteria optimization in radiation therapy treatment planning." Thesis, KTH, Matematisk statistik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-257509.

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In radiation therapy treatment planning, recent works have used machine learning based on historically delivered plans to automate the process of producing clinically acceptable plans. Compared to traditional approaches such as repeated weighted-sum optimization or multicriteria optimization (MCO), automated planning methods have, in general, the benefits of low computational times and minimal user interaction, but on the other hand lack the flexibility associated with general-purpose frameworks such as MCO. Machine learning approaches can be especially sensitive to deviations in their dose pr

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Wadlow, Philip James. "MATERIAL SELECTION AND TESTING FOR A RADIATION THERAPY CATHETER." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1661.

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Three different polymers (a high-density polymer and two other polymers) were tested for use as an x-ray catheter in a radiation therapy application. This report describes the testing of these three materials to determine which material is the best option for a long use catheter. Tests included tensile, simulated clinical life, and other tests. Some testing was performed using nitrogen and an industrial coolant. Testing revealed significant non-circularities for some catheters. With increasing pressure, the circularity of these catheters increased. The tensile tests were performed on samples w

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