Einloggen

Thematische Bibliographien / RORα / Zeitschriftenartikel

Um die anderen Arten von Veröffentlichungen zu diesem Thema anzuzeigen, folgen Sie diesem Link: RORα.

Zeitschriftenartikel zum Thema „RORα“

Autor: Grafiati

Veröffentlicht am 25. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an

Wählen Sie eine Art der Quelle aus:

Machen Sie sich mit Top-50 Zeitschriftenartikel für die Forschung zum Thema "RORα" bekannt.

Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.

Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.

Sehen Sie die Zeitschriftenartikel für verschiedene Spezialgebieten durch und erstellen Sie Ihre Bibliographie auf korrekte Weise.

1

Kang, Hong Soon, Martin Angers, Ju Youn Beak та ін. "Gene expression profiling reveals a regulatory role for RORα and RORγ in phase I and phase II metabolism". Physiological Genomics 31, № 2 (2007): 281–94. http://dx.doi.org/10.1152/physiolgenomics.00098.2007.

Der volle Inhalt der Quelle

Annotation:

Retinoid-related orphan receptors alpha (RORα) and gamma (RORγ) are both expressed in liver; however, their physiological functions in this tissue have not yet been clearly defined. The RORα1 and RORγ1 isoforms, but not RORα4, show an oscillatory pattern of expression during circadian rhythm. To obtain insight into the physiological functions of ROR receptors in liver, we analyzed the gene expression profiles of livers from WT, RORα-deficient staggerer (sg) mice ( RORα sg/sg), RORγ−/−, and RORα sg/sg RORγ−/− double knockout (DKO) mice by microarray analysis. DKO mice were generated to study fu

APA, Harvard, Vancouver, ISO und andere Zitierweisen

2

Park, Su, Il-Geun Park, Hyunkyung Kim та Ji Lee. "N-Terminal Domain Mediated Regulation of RORα1 Inhibits Invasive Growth in Prostate Cancer". International Journal of Molecular Sciences 20, № 7 (2019): 1684. http://dx.doi.org/10.3390/ijms20071684.

Der volle Inhalt der Quelle

Annotation:

Four members of the retinoic acid-related orphan receptor α (RORα) family (RORα1, RORα2, RORα3 and RORα4) are transcription factors that regulate several processes including circadian rhythm, lipid metabolism, cerebellar development, immune function, and cancer. Only two isoforms, RORα1 and 4, are specifically co-expressed in the murine and human. In the present study, we identified a specific N-terminal domain (NTD) of RORα1 that potentiated the downregulation of target genes involved in tumor progression and proliferation, based on results from RORα-deficient mouse embryonic fibroblasts and

APA, Harvard, Vancouver, ISO und andere Zitierweisen

3

Jetten, Anton M. "Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism." Nuclear Receptor Signaling 7, no. 1 (2009): nrs.07003. http://dx.doi.org/10.1621/nrs.07003.

Der volle Inhalt der Quelle

Annotation:

The last few years have witnessed a rapid increase in our knowledge of the retinoid-related orphan receptors RORα, -β, and -γ (NR1F1-3), their mechanism of action, physiological functions, and their potential role in several pathologies. The characterization of ROR-deficient mice and gene expression profiling in particular have provided great insights into the critical functions of RORs in the regulation of a variety of physiological processes. These studies revealed that RORa plays a critical role in the development of the cerebellum, that both RORα and RORβ are required for the maturation of

APA, Harvard, Vancouver, ISO und andere Zitierweisen

4

Wada, Taira, Hong Soon Kang, Anton M. Jetten та Wen Xie. "The Emerging Role of Nuclear Receptor RORα and Its Crosstalk with LXR in Xeno- and Endobiotic Gene Regulation". Experimental Biology and Medicine 233, № 10 (2008): 1191–201. http://dx.doi.org/10.3181/0802-mr-50.

Der volle Inhalt der Quelle

Annotation:

Retinoid-related orphan receptors (RORs), including the α, β and γ isoforms (NR1F1–3), are orphan nuclear receptors that have been implicated in tissue development, immune responses, and circadian rhythm. Although RORα and RORγ have been shown to be expressed in the liver, the hepatic function of these two RORs remains unknown. We have recently shown that loss of RORα and/or RORγ can positively or negatively influence the expression of multiple Phase I and Phase II drug metabolizing enzymes and transporters in the liver. Among ROR responsive genes, we identified oxysterol 7α-hydroxylase (Cyp7b

APA, Harvard, Vancouver, ISO und andere Zitierweisen

5

CHAUVET, Caroline, Brigitte BOIS-JOYEUX та Jean-Louis DANAN. "Retinoic acid receptor-related orphan receptor (ROR) α4 is the predominant isoform of the nuclear receptor RORα in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells". Biochemical Journal 364, № 2 (2002): 449–56. http://dx.doi.org/10.1042/bj20011558.

Der volle Inhalt der Quelle

Annotation:

The retinoic acid receptor-related orphan receptor α (RORα) is critically involved in many physiological functions in several organs. We find that the main RORα isoform in the mouse liver is the RORα4 isoform, in terms of both mRNA and protein levels, while the RORα1 isoform is less abundant. Because hypoxia is a major feature of liver physiology and pathology, we examined the effect of this stress on Rora gene expression and RORα transcriptional activity. HepG2 human hepatoma cells were cultured for 24h under normoxia (20% O2) or hypoxia (10, 2, and 0.1% O2) and the abundance of the Rora tran

APA, Harvard, Vancouver, ISO und andere Zitierweisen

6

Nematisouldaragh, Darya, Eryn Kirshenbaum, Michael Uzonna, Lorrie Kirshenbaum, and Inna Rabinovich-Nikitin. "The Role of Retinoic-Acid-Related Orphan Receptor (RORs) in Cellular Homeostasis." International Journal of Molecular Sciences 25, no. 21 (2024): 11340. http://dx.doi.org/10.3390/ijms252111340.

Der volle Inhalt der Quelle

Annotation:

Retinoic-acid-related orphan receptors (RORs) are transcription factors belonging to the nuclear receptor subfamily consisting of RORα, RORβ, and RORγ. By binding to the ROR response elements (ROREs) on target gene promoters, RORs regulate a wide variety of cellular processes, including autophagy, mitophagy, oxidative stress, and inflammation. The regulatory roles of RORs are observed in cardiac cells, hepatocytes, pulmonary epithelial cells, renal cells, immune cells, and cancer cells. A growing body of clinical and experimental evidence suggests that ROR expression levels are markedly reduce

APA, Harvard, Vancouver, ISO und andere Zitierweisen

7

Koibuchi, Noriyuki, Ying Liu, Harumi Fukuda, Akira Takeshita, Paul M. Yen та William W. Chin. "RORα Augments Thyroid Hormone Receptor-Mediated Transcriptional Activation*". Endocrinology 140, № 3 (1999): 1356–64. http://dx.doi.org/10.1210/endo.140.3.6562.

Der volle Inhalt der Quelle

Annotation:

Abstract This study is designed to clarify the role of an orphan nuclear hormone receptor, RORα, on thyroid hormone (TH) receptor (TR)-mediated transcription on a TH-response element (TRE). A transient transfection study using various TREs [i.e., F2 (chick lysozyme TRE), DR4 (direct repeat), and palindrome TRE] and TR and RORα1 was performed. When RORα1 and TR were cotransfected into CV1 cells, RORα1 enhanced the transactivation by liganded-TR on all TREs tested without an effect on basal repression by unliganded TR. By electrophoretic mobility shift assay, on the other hand, although RORα bou

APA, Harvard, Vancouver, ISO und andere Zitierweisen

8

Song, Hyerin, Jung Woong Chu, Su Chan Park та ін. "Isoform-Specific Lysine Methylation of RORα2 by SETD7 Is Required for Association of the TIP60 Coactivator Complex in Prostate Cancer Progression". International Journal of Molecular Sciences 21, № 5 (2020): 1622. http://dx.doi.org/10.3390/ijms21051622.

Der volle Inhalt der Quelle

Annotation:

The retinoid acid-related orphan receptor α (RORα), a member of the orphan nuclear receptor superfamily, functions as an unknown ligand-dependent transcription factor. RORα was shown to regulate a broad array of physiological processes such as Purkinje cell development in the cerebellum, circadian rhythm, lipid and bone metabolism, inhibition of inflammation, and anti-apoptosis. The human RORα gene encodes at least four distinct isoforms (RORα1, -2, -3, -4), which differ only in their N-terminal domain (NTD). Two isoforms, RORα2 and 3, are not expressed in mice, whereas RORα1 and 4 are express

APA, Harvard, Vancouver, ISO und andere Zitierweisen

9

Zhang, Yijia, Zixu Wang, Yulan Dong, Jing Cao та Yaoxing Chen. "Melatonin Nuclear Receptors Mediate Green-and-Blue-Monochromatic-Light-Combinations-Inhibited B Lymphocyte Apoptosis in the Bursa of Chickens via Reducing Oxidative Stress and Nfκb Expression". Antioxidants 11, № 4 (2022): 748. http://dx.doi.org/10.3390/antiox11040748.

Der volle Inhalt der Quelle

Annotation:

Previous studies found that melatonin modulates a combination of green-and-blue-light-induced B-lymphocyte proliferation via its membrane receptors Mel1a and Mel1c. However, in addition to its membrane-bound receptors, melatonin also functions through binding to nuclear receptors RORα/RORβ/RORγ. In this study, we raised 120 chicks under 400–700 nm white (WW), 660 nm red (RR), 560 nm green (GG) and 480 nm blue light (BB) from P0 to P26. From P27 to P42, half of the chickens in green, blue and red were switched to blue (G→B), green (B→G) and red (R→B), respectively. We used immunohistochemistry,

APA, Harvard, Vancouver, ISO und andere Zitierweisen

10

Qiu, Chun-Hong, Noriaki Shimokawa, Toshiharu Iwasaki, Ishwar S. Parhar та Noriyuki Koibuchi. "Alteration of Cerebellar Neurotropin Messenger Ribonucleic Acids and the Lack of Thyroid Hormone Receptor Augmentation by staggerer-Type Retinoic Acid Receptor-Related Orphan Receptor-α Mutation". Endocrinology 148, № 4 (2007): 1745–53. http://dx.doi.org/10.1210/en.2006-1131.

Der volle Inhalt der Quelle

Annotation:

The mutant mouse staggerer (sg) harbors a deletion within the gene encoding the retinoic acid receptor-related orphan receptor-α (RORα). Homozygotes show aberrant cerebellar development. However, the mechanisms responsible for the cerebellar defect are still poorly understood. In the present study, the involvement of neurotropins (NTs), including nerve growth factor, brain-derived neurotropic factor, NT-3 and NT-4/5, and their receptors, which play a crucial role in brain development, on the cerebellar defects of sg mice was studied by semiquantitative RT-PCR and in situ hybridization histoche

APA, Harvard, Vancouver, ISO und andere Zitierweisen

11

Doebelin, Christelle, Yuanjun He, Sean Campbell та ін. "Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-Related Orphan Receptor-α". Medicinal Chemistry 15, № 6 (2019): 676–84. http://dx.doi.org/10.2174/1573406415666190222124745.

Der volle Inhalt der Quelle

Annotation:

Background: Despite a massive industry endeavor to develop RORγ-modulators for autoimmune disorders, there has been no indication of efforts to target the close family member RORα for similar indications. This may be due to the misconception that RORα is redundant to RORγ, or the inherent difficulty in cultivating tractable starting points for RORα. RORα-selective modulators would be useful tools to interrogate the biology of this understudied orphan nuclear receptor. Objectives: he goal of this research effort was to identify and optimize synthetic ligands for RORα starting from the known LXR

APA, Harvard, Vancouver, ISO und andere Zitierweisen

12

Ortiz, Maria A., F. Javier Piedrafita, and Adel Nefzi. "1,5-Disubstituted Acylated 2-Amino-4,5-dihydroimidazoles as a New Class of Retinoic Acid Receptor–Related Orphan Receptor (ROR) Inhibitors." International Journal of Molecular Sciences 23, no. 8 (2022): 4433. http://dx.doi.org/10.3390/ijms23084433.

Der volle Inhalt der Quelle

Annotation:

A growing body of evidence suggests a pathogenic role for pro-inflammatory T helper 17 cells (Th17) in several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type I diabetes, and psoriasis—diseases for which no curative treatment is currently available. The nuclear retinoic acid receptor–related orphan receptors alpha and gamma (RORα/γ), in particular the truncated isoform RORγt that is specifically expressed in the thymus, play a critical role in the activation of a pro-inflammatory Th17 response, and RORγ inverse agonists have shown promi

APA, Harvard, Vancouver, ISO und andere Zitierweisen

13

Gu, Feng, Yuming Liu, Yuan Liu, et al. "Distinct functions and prognostic values of RORs in gastric cancer." Open Medicine 15, no. 1 (2020): 424–34. http://dx.doi.org/10.1515/med-2020-0406.

Der volle Inhalt der Quelle

Annotation:

AbstractRetinoic acid receptor-related orphan receptors (RORs) are frequently abnormally expressed in several human malignancies, including gastric cancer (GC). RORs are involved in the development and progression of GC through Wnt signaling pathway receptors and other common receptors. However, the prognostic roles of individual RORs in patients with GC remain elusive. We accessed the prognostic roles of three RORs (RORα, RORβ, and RORγ) through “The Kaplan–Meier plotter” (KM plotter) database in patients with GC. For all patients with GC who were followed for 20 years, the low mRNA expressio

APA, Harvard, Vancouver, ISO und andere Zitierweisen

14

Lee, Hyun-Ku, Jennifer McAlpine, Sriram Chitta, et al. "Characterization of a small molecule compound VPR-66 as an inverse agonist for ROR proteins (P5167)." Journal of Immunology 190, no. 1_Supplement (2013): 68.11. http://dx.doi.org/10.4049/jimmunol.190.supp.68.11.

Der volle Inhalt der Quelle

Annotation:

Abstract Retinoic Acid Receptor (RAR)-Related Orphan Receptors RORα, RORγ and RORγt are key transcription factors required for differentiation of naive CD4+ helper cells into Th17 cells that play an important role in driving autoimmune and inflammatory diseases by secretion of IL-17 and other pro-inflammatory cytokines. Recently development of the Th17 immunomodulators as potential therapeutics for autoimmune diseases has been focused on ROR proteins to regulate differentiation and IL-17 production of Th17 cells. We designed a small molecule compound VPR-66 via the molecular modeling study, wh

APA, Harvard, Vancouver, ISO und andere Zitierweisen

15

Kim, Eunju, Kazuaki Mawatari, Seung-Hee Yoo та Zheng Chen. "The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes". Nutrients 15, № 18 (2023): 3919. http://dx.doi.org/10.3390/nu15183919.

Der volle Inhalt der Quelle

Annotation:

Obesity is a known risk factor for metabolic diseases and is often associated with chronic inflammation in adipose tissue. We previously identified the polyethoxylated flavonoid Nobiletin (NOB) as a circadian clock modulator that directly binds to and activates the ROR receptors in the core oscillator, markedly improving metabolic fitness in obese mice. Here, we show that NOB enhanced the oscillation of core clock genes in differentiated 3T3-L1 adipocytes, including ROR target genes such as Bmal1, Cry1, Dec1, and Dec2. NOB inhibited lipid accumulation in 3T3-L1 and SVF cells, concomitant with

APA, Harvard, Vancouver, ISO und andere Zitierweisen

16

Solt, Laura A., Ran Wang, Mohammed Amir та ін. "A non-redundant role for RORα in TH17 cell development and TH17-driven inflammatory disorders". Journal of Immunology 200, № 1_Supplement (2018): 121.3. http://dx.doi.org/10.4049/jimmunol.200.supp.121.3.

Der volle Inhalt der Quelle

Annotation:

Abstract Dysregulated TH17 immune responses have been associated with the pathogenesis of several autoimmune diseases. While full development of TH17 cells requires both nuclear receptors RORα and RORγt, most of the work surrounding TH17 cells has focused on the lineage defining transcription factor RORγt. However, TH17 cells are not absent in RORγ−/− mice, suggesting that RORα plays an important role. Despite this, RORα is considered redundant to RORγt and little is known about its function in TH17 cells. The aim of this study was to determine whether RORα played a significant role in TH17 ce

APA, Harvard, Vancouver, ISO und andere Zitierweisen

17

Hua, Xiangmei, Conrad Dean Blosch, Hannah Dorsey та ін. "Epidermal Loss of RORα Enhances Skin Inflammation in a MC903-Induced Mouse Model of Atopic Dermatitis". International Journal of Molecular Sciences 24, № 12 (2023): 10241. http://dx.doi.org/10.3390/ijms241210241.

Der volle Inhalt der Quelle

Annotation:

Atopic dermatitis (AD) is a chronic inflammatory skin disease featuring skin barrier dysfunction and immune dysregulation. Previously, we reported that the retinoid-related orphan nuclear receptor RORα was highly expressed in the epidermis of normal skin. We also found that it positively regulated the expression of differentiation markers and skin barrier-related genes in human keratinocytes. In contrast, epidermal RORα expression was downregulated in the skin lesions of several inflammatory skin diseases, including AD. In this study, we generated mouse strains with epidermis-specific Rora abl

APA, Harvard, Vancouver, ISO und andere Zitierweisen

18

Brożyna, Anna A., Tae-Kang Kim, Marzena Zabłocka, et al. "Association among Vitamin D, Retinoic Acid-Related Orphan Receptors, and Vitamin D Hydroxyderivatives in Ovarian Cancer." Nutrients 12, no. 11 (2020): 3541. http://dx.doi.org/10.3390/nu12113541.

Der volle Inhalt der Quelle

Annotation:

Vitamin D and its derivatives, acting via the vitamin D receptor (VDR) and retinoic acid-related orphan receptors γ and α (RORγ and RORα), show anticancer properties. Since pathological conditions are characterized by disturbances in the expression of these receptors, in this study, we investigated their expression in ovarian cancers (OCs), as well as explored the phenotypic effects of vitamin D hydroxyderivatives and RORγ/α agonists on OC cells. The VDR and RORγ showed both a nuclear and a cytoplasmic location, and their expression levels were found to be reduced in the primary and metastatic

APA, Harvard, Vancouver, ISO und andere Zitierweisen

19

Raspè, Eric, Gisèle Mautino, Caroline Duval та ін. "Transcriptional Regulation of HumanRev-erbαGene Expression by the Orphan Nuclear Receptor Retinoic Acid-related Orphan Receptor α". Journal of Biological Chemistry 277, № 51 (2002): 49275–81. http://dx.doi.org/10.1074/jbc.m206215200.

Der volle Inhalt der Quelle

Annotation:

The Rev-erb and retinoic acid-related orphan receptors (ROR) are two related families of orphan nuclear receptors that recognize similar response elements but have opposite effects on transcription. Recently, theRev-erbαgene promoter has been characterized and shown to harbor a functional Rev-erbα-binding site known as Rev-DR2, responsible for negative feedback down-regulation of promoter activity by Rev-erbα itself. The present study aimed to investigate whetherRev-erbαgene expression is regulated by RORα. Gel shift analysis demonstrated thatin vitrotranslated hRORα1 protein binds to the Rev-

APA, Harvard, Vancouver, ISO und andere Zitierweisen

20

Hua, Xiangmei, Maria K. Ficaro, Nicole L. Wallace та Jun Dai. "Epidermal RORα Maintains Barrier Integrity and Prevents Allergic Inflammation by Regulating Late Differentiation and Lipid Metabolism". International Journal of Molecular Sciences 25, № 19 (2024): 10698. http://dx.doi.org/10.3390/ijms251910698.

Der volle Inhalt der Quelle

Annotation:

The skin epidermis provides a barrier that is imperative for preventing transepidermal water loss (TEWL) and protecting against environmental stimuli. The underlying molecular mechanisms for regulating barrier functions and sustaining its integrity remain unclear. RORα is a nuclear receptor highly expressed in the epidermis of normal skin. Clinical studies showed that the epidermal RORα expression is significantly reduced in the lesions of multiple inflammatory skin diseases. In this study, we investigate the central roles of RORα in stabilizing skin barrier function using mice with an epiderm

APA, Harvard, Vancouver, ISO und andere Zitierweisen

21

Pan, Wen-An, Xin Guo, Christina Galang, et al. "Abstract LB187: Investigating the roles of ROR1/2 in non-small cell lung carcinoma NSCLC and potential therapeutic applications." Cancer Research 84, no. 7_Supplement (2024): LB187. http://dx.doi.org/10.1158/1538-7445.am2024-lb187.

Der volle Inhalt der Quelle

Annotation:

Abstract Lung cancer is the leading cause of cancer mortality worldwide, representing an unmet medical need. Receptor tyrosine kinase-like orphan receptors (RORs) are oncofetal antigens that act as receptors/co-receptors of WNT5A and other related noncanonical WNT proteins, in transducing β-catenin independent WNT signaling. Dysregulated ROR/WNT have been linked to cancer progression and therapy resistance. Recently, ROR receptors have drawn increasing attention as anti-cancer targets of antibody-drug conjugates (ADCs) due to their selective expression on the tumor cell surface. The ROR family

APA, Harvard, Vancouver, ISO und andere Zitierweisen

22

Solt, Laura A., Ran Wang, Mohammed Amir та ін. "Genetic and pharmacological modulation of RORα regulates TH17-driven inflammatory disorders". Journal of Immunology 202, № 1_Supplement (2019): 68.11. http://dx.doi.org/10.4049/jimmunol.202.supp.68.11.

Der volle Inhalt der Quelle

Annotation:

Abstract While RORγt has been well characterized as the lineage defining transcription factor for TH17 cell development, TH17 cells are not absent in Rorc-deficient mice, suggesting other factors may be required. RORα, a close family member of RORγt, is also expressed during TH17 cell development but is considered functionally redundant, thus little is known about its function in TH17 cells. Using mouse models of autoimmunity and chronic inflammation, we show that expression of RORα is required for TH17 pathogenicity. T-cell specific deletion of RORα significantly abrogated the development of

APA, Harvard, Vancouver, ISO und andere Zitierweisen

23

Schwarz, Patrik F., Alexander F. Perhal, Lucia N. Schöberl, Martin M. Kraus, Johannes Kirchmair та Verena M. Dirsch. "Identification of the Natural Steroid Sapogenin Diosgenin as a Direct Dual-Specific RORα/γ Inverse Agonist". Biomedicines 10, № 9 (2022): 2076. http://dx.doi.org/10.3390/biomedicines10092076.

Der volle Inhalt der Quelle

Annotation:

The steroid sapogenin diosgenin is a well-known natural product with a plethora of described pharmacological activities including the amelioration of T helper 17 (Th17)-driven pathologies. However, the exact underlying mode of action of diosgenin leading to a dampened Th17 response is still largely unknown and specific molecular targets have yet to be identified. Here, we show that diosgenin acts as a direct ligand and inverse agonist of the nuclear receptor retinoic acid receptor (RAR)-related orphan receptor (ROR)α and RORγ, which are key transcription factors involved in Th17 cell different

APA, Harvard, Vancouver, ISO und andere Zitierweisen

24

Willson, Timothy M. "RORα". Structure 10, № 12 (2002): 1605–6. http://dx.doi.org/10.1016/s0969-2126(02)00916-4.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

25

Matysiak-Scholze, Uta, та Michael Nehls. "The Structural Integrity of RORα Isoforms Is Mutated instaggererMice: Cerebellar Coexpression of RORα1 and RORα4". Genomics 43, № 1 (1997): 78–84. http://dx.doi.org/10.1006/geno.1997.4757.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

26

CHAUVET, Caroline, Brigitte BOIS-JOYEUX, Edurne BERRA, Jacques POUYSSEGUR та Jean-Louis DANAN. "The gene encoding human retinoic acid-receptor-related orphan receptor α is a target for hypoxia-inducible factor 1". Biochemical Journal 384, № 1 (2004): 79–85. http://dx.doi.org/10.1042/bj20040709.

Der volle Inhalt der Quelle

Annotation:

Retinoic acid-receptor-related orphan receptor (ROR) α is a nuclear receptor involved in many pathophysiological processes such as cerebellar ataxia, inflammation, atherosclerosis and angiogenesis. In the present study we first demonstrate that hypoxia increases the amount of Rora transcripts in a wide panel of cell lines derived from diverse tissues. In addition, we identified a functional promoter sequence upstream of the first exon of the human Rora gene, spanning −487 and −45 from the translation initiation site of RORα1. When cloned in a luciferase reporter vector, this sequence allowed t

APA, Harvard, Vancouver, ISO und andere Zitierweisen

27

Istrate, Monica A., Timothy P. Spicer, Yan Wang та ін. "Development of an HTS-Compatible Assay for Discovery of RORα Modulators Using AlphaScreen® Technology". Journal of Biomolecular Screening 16, № 2 (2011): 183–91. http://dx.doi.org/10.1177/1087057110389040.

Der volle Inhalt der Quelle

Annotation:

The retinoid acid receptor–related orphan receptors (RORs) represent important targets for the treatment of metabolic and immune disorders. Here the authors describe the application of AlphaScreen® technology to develop a high-throughput screening (HTS)–compatible assay to facilitate the discovery of RORα modulators. Using the ligand binding domain (LBD) of RORα and a peptide derived from the NR1 box of the nuclear receptor coactivator PGC-1α, a 384-well format assay was developed exhibiting high sensitivity, requiring only low nanomolar concentration of reagents. Recently, it was shown that o

APA, Harvard, Vancouver, ISO und andere Zitierweisen

28

Lee, Ji Min, Hyunkyung Kim, Hyuntae Im, and Hee-ji Baek. "Abstract 1493: ROS inhibits enzymatic activation of PRMT5 and increases the protein stability of tumor suppressors as non-histone substrates in liver cancer." Cancer Research 83, no. 7_Supplement (2023): 1493. http://dx.doi.org/10.1158/1538-7445.am2023-1493.

Der volle Inhalt der Quelle

Annotation:

Abstract Retinoic acid receptor-related orphan receptor α (RORα) and p53 are transcription factors involved in nuclear gene expression and known tumor suppressors. RORα was the first identified substrate of lysine methylation-dependent degradation. However, the mechanisms of other post-translational modifications (PTMs) that occur in RORα and p53 remain largely unknown, especially in liver cancer. Arginine methylation is a common PTM in arginine residues of nonhistone and histone proteins and affects substrate protein function and fate. We found an analogous amino acid disposition containing R

APA, Harvard, Vancouver, ISO und andere Zitierweisen

29

Xiong, Gaofeng, Brynne Obringer, Austen Jones, Elise Horton та Ren Xu. "Regulation of RORα Stability through PRMT5-Dependent Symmetric Dimethylation". Cancers 16, № 10 (2024): 1914. http://dx.doi.org/10.3390/cancers16101914.

Der volle Inhalt der Quelle

Annotation:

Retinoic acid receptor-related orphan receptor alpha (RORα), a candidate tumor suppressor, is prevalently downregulated or lost in malignant breast cancer cells. However, the mechanisms of how RORα expression is regulated in breast epithelial cells remain incompletely understood. Protein arginine N-methyltransferase 5 (PRMT5), a type II methyltransferase catalyzing the symmetric methylation of the amino acid arginine in target proteins, was reported to regulate protein stability. To study whether and how PRMT5 regulates RORα, we examined the direct interaction between RORα and PRMT5 by immunop

APA, Harvard, Vancouver, ISO und andere Zitierweisen

30

Kang, Hong Soon, Kyoko Okamoto, Yukimasa Takeda та ін. "Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis". Physiological Genomics 43, № 13 (2011): 818–28. http://dx.doi.org/10.1152/physiolgenomics.00206.2010.

Der volle Inhalt der Quelle

Annotation:

Retinoid-related orphan receptor (ROR)α4 is the major RORα isoform expressed in adipose tissues and liver. In this study we demonstrate that RORα-deficient staggerer mice (RORαsg/sg) fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels compared with wild-type (WT) littermates and were resistant to the development of hepatic steatosis, adipose-associated inflammation, and insulin resistance. Gene expression profiling showed that many genes involved in triglyceride synthesis and storage, including Cidec, Cidea, and Mogat1, were expressed at much lower levels

APA, Harvard, Vancouver, ISO und andere Zitierweisen

31

Chen, Yun, Shu-Ping Zhang, Wei-Wei Gong та ін. "Novel Therapeutic Potential of Retinoid-Related Orphan Receptor α in Cardiovascular Diseases". International Journal of Molecular Sciences 24, № 4 (2023): 3462. http://dx.doi.org/10.3390/ijms24043462.

Der volle Inhalt der Quelle

Annotation:

The retinoid-related orphan receptor α (RORα) is one subfamily of nuclear hormone receptors (NRs). This review summarizes the understanding and potential effects of RORα in the cardiovascular system and then analyzes current advances, limitations and challenges, and further strategy for RORα-related drugs in cardiovascular diseases. Besides regulating circadian rhythm, RORα also influences a wide range of physiological and pathological processes in the cardiovascular system, including atherosclerosis, hypoxia or ischemia, myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, hyperte

APA, Harvard, Vancouver, ISO und andere Zitierweisen

32

Halim, Timotheus, Aric MacLaren, Mark Romanish, Matthew Gold, Kelly McNagny, and Fumio Takei. "ROR-alpha is required for natural helper cell development in all tissues from a bone-marrow derived progenitor and the induction of allergic inflammation (67.11)." Journal of Immunology 188, no. 1_Supplement (2012): 67.11. http://dx.doi.org/10.4049/jimmunol.188.supp.67.11.

Der volle Inhalt der Quelle

Annotation:

Abstract Natural Helper (NH) cells are Th2 cytokine-producing innate lymphoid cells (ILCs) in, or associated with the mucosal tissues of the lung and gut. Currently, the lineage relationship between NH cells in different tissues and between NH cells and interleukin-22 (IL-22)-producing retinoid receptor-related orphan receptor (ROR)γt-positive ILCs is unclear. Here, we report that NH cells express RORα but not RORγt. RORα-deficient, but not RORγt-deficient, mice lack NH cells in the lung, small and large intestines while all other lymphocytes including RORγt+ ILCs are unaffected. We have also

APA, Harvard, Vancouver, ISO und andere Zitierweisen

33

Beak, Ju Youn, Hong Soon Kang, Wei Huang та ін. "The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure". American Journal of Physiology-Heart and Circulatory Physiology 316, № 1 (2019): H186—H200. http://dx.doi.org/10.1152/ajpheart.00531.2018.

Der volle Inhalt der Quelle

Annotation:

The nuclear receptor retinoic acid-related orphan receptor-α (RORα) regulates numerous critical biological processes, including central nervous system development, lymphocyte differentiation, and lipid metabolism. RORα has been recently identified in the heart, but very little is known about its role in cardiac physiology. We sought to determine whether RORα regulates myocardial hypertrophy and cardiomyocyte survival in the context of angiotensin II (ANG II) stimulation. For in vivo characterization of the function of RORα in the context of pathological cardiac hypertrophy and heart failure, w

APA, Harvard, Vancouver, ISO und andere Zitierweisen

34

Brożyna, Anna A., Wojciech Jóźwicki, Cezary Skobowiat, Anton Jetten та Andrzej T. Slominski. "RORα and RORγ expression inversely correlates with human melanoma progression". Oncotarget 7, № 39 (2016): 63261–82. http://dx.doi.org/10.18632/oncotarget.11211.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

35

Sun, Ye, Chi-Hsiu Liu, John Paul SanGiovanni та ін. "Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation". Proceedings of the National Academy of Sciences 112, № 33 (2015): 10401–6. http://dx.doi.org/10.1073/pnas.1504387112.

Der volle Inhalt der Quelle

Annotation:

Pathologic ocular angiogenesis is a leading cause of blindness, influenced by both dysregulated lipid metabolism and inflammation. Retinoic-acid-receptor–related orphan receptor alpha (RORα) is a lipid-sensing nuclear receptor with diverse biologic function including regulation of lipid metabolism and inflammation; however, its role in pathologic retinal angiogenesis remains poorly understood. Using a mouse model of oxygen-induced proliferative retinopathy, we showed that RORα expression was significantly increased and genetic deficiency of RORα substantially suppressed pathologic retinal neov

APA, Harvard, Vancouver, ISO und andere Zitierweisen

36

Kang, Jun, Haoling Chen, Fuping Zhang та ін. "RORα Regulates Odontoblastic Differentiation and Mediates the Pro-Odontogenic Effect of Melatonin on Dental Papilla Cells". Molecules 26, № 4 (2021): 1098. http://dx.doi.org/10.3390/molecules26041098.

Der volle Inhalt der Quelle

Annotation:

Dental papilla cells (DPCs), precursors of odontoblasts, are considered promising seed cells for tissue engineering. Emerging evidence suggests that melatonin promotes odontoblastic differentiation of DPCs and affects tooth development, although the precise mechanisms remain unknown. Retinoid acid receptor-related orphan receptor α (RORα) is a nuclear receptor for melatonin that plays a critical role in cell differentiation and embryonic development. This study aimed to explore the role of RORα in odontoblastic differentiation and determine whether melatonin exerts its pro-odontogenic effect v

APA, Harvard, Vancouver, ISO und andere Zitierweisen

37

Zhang, Yu, Xuefei Zhao, Shuqi Li, Suying Bai, and Wei Zhang. "Retinoic-Acid-Related Orphan Receptor Alpha Is Involved in the Regulation of the Cytoskeleton of Hair Follicle Stem Cells." Biomolecules 15, no. 6 (2025): 863. https://doi.org/10.3390/biom15060863.

Der volle Inhalt der Quelle

Annotation:

The development and replacement of hair play a significant role in the life history of animals. In recent years, retinoic-acid-related orphan receptor alpha (Rorα) has been found to participate in the regulation of hair follicle development, yet the underlying mechanisms remain incompletely understood. This study aims to analyze the regulatory role of Rorα on the cytoskeleton of hair follicle stem cells (HFSCs). We treated HFSCs with a RORA agonist and subsequently analyzed differential gene expression using qPCR, Western blotting, and immunofluorescence, finding that agonist-induced activatio

APA, Harvard, Vancouver, ISO und andere Zitierweisen

38

Xu, Yijiang, Justin Moroney, Yulai Zhou, Hong Zan та Paolo Casali. "RORα plays an important role in generation and maintenance of memory B cells". Journal of Immunology 210, № 1_Supplement (2023): 76.02. http://dx.doi.org/10.4049/jimmunol.210.supp.76.02.

Der volle Inhalt der Quelle

Annotation:

Abstract Memory B cells (MBCs) are antigen-specific and long-lived. Upon reactivation, they can differentiate into plasma cells to secrete large amounts of high-affinity mostly class-switched antibodies. Prompted by our integrative analysis of the human MBC transcriptome and chromatin landscape which redundantly identified the transcriptional factor RORα as central to the identity of human class-switched (sw)MBCs, we investigated the contribution of RORα to the generation and maintenance of MBCs. We found that RORα is selectively expressed at a high level in both human and mouse swMBCs. We the

APA, Harvard, Vancouver, ISO und andere Zitierweisen

39

Kuklina, E. M. "Mechanisms of RORα-dependent effects of melatonin". Russian Journal of Immunology 27, № 2 (2024): 203–6. http://dx.doi.org/10.46235/1028-7221-16625-mor.

Der volle Inhalt der Quelle

Annotation:

The transcription factor RORα has not traditionally been attributed a fundamental role in the development of Th17 cells, but recent studies have shown that it is necessary for the formation of a pathogenic variant of Th17 cells, the so-called Th1-polarized Th17 (Th17.1). Since the transcriptional activity of RORα depends on ligand binding, the search for such ligands is highly relevant, and in this regard, melatonin is of particular interest. The question of the ability of RORα to directly bind melatonin remains open today; data on this problem are extremely contradictory. In 1995, I. Wiesenbe

APA, Harvard, Vancouver, ISO und andere Zitierweisen

40

Lee, Ji Min, Hyunkyung Kim та Sung Hee Baek. "Unraveling the physiological roles of retinoic acid receptor-related orphan receptor α". Experimental & Molecular Medicine 53, № 9 (2021): 1278–86. http://dx.doi.org/10.1038/s12276-021-00679-8.

Der volle Inhalt der Quelle

Annotation:

AbstractRetinoic acid receptor-related orphan receptor-α (RORα) is a member of the orphan nuclear receptor family and functions as a transcriptional activator in response to circadian changes. Circadian rhythms are complex cellular mechanisms regulating diverse metabolic, inflammatory, and tumorigenic gene expression pathways that govern cyclic cellular physiology. Disruption of circadian regulators, including RORα, plays a critical role in tumorigenesis and facilitates the development of inflammatory hallmarks. Although RORα contributes to overall fitness among anticancer, anti-inflammatory,

APA, Harvard, Vancouver, ISO und andere Zitierweisen

41

Kadiri, Sarah, Chloé Monnier, Munkhzul Ganbold, Tatiana Ledent, Jacqueline Capeau та Bénédicte Antoine. "The nuclear retinoid-related orphan receptor-α regulates adipose tissue glyceroneogenesis in addition to hepatic gluconeogenesis". American Journal of Physiology-Endocrinology and Metabolism 309, № 2 (2015): E105—E114. http://dx.doi.org/10.1152/ajpendo.00518.2014.

Der volle Inhalt der Quelle

Annotation:

Circadian rhythms have an essential role in feeding behavior and metabolism. RORα is a nuclear receptor involved in the interface of the circadian system and metabolism. The adipocyte glyceroneogenesis pathway derives free fatty acids (FFA) liberated by lipolysis to reesterification into triglycerides, thus regulating FFA homeostasis and fat mass. Glyceroneogenesis shares with hepatic gluconeogenesis the key enzyme phospho enolpyruvate carboxykinase c (PEPCKc), whose gene is a RORα target in the liver. RORα-deficient mice (staggerer, RORsg/sg ) have been shown to exhibit a lean phenotype and f

APA, Harvard, Vancouver, ISO und andere Zitierweisen

42

Okada, Kosuke, Takeki Fujimura, Takeshi Kikuchi, et al. "Effect of interleukin (IL)-35 on IL-17 expression and production by human CD4+ T cells." PeerJ 5 (February 15, 2017): e2999. http://dx.doi.org/10.7717/peerj.2999.

Der volle Inhalt der Quelle

Annotation:

Background Interleukin (IL)-17 produced by mainly T helper 17 (Th17) cells may play an important destructive role in chronic periodontitis (CP). Thus, anti-inflammatory cytokines, such as IL-35, might have a beneficial effect in periodontitis by inhibiting differentiation of Th17 cells. Th17 differentiation is regulated by the retinoic acid receptor-related orphan receptor (ROR) α (encoded by RORA) and RORγt (encoded by RORC). However, the role of IL-35 in periodontitis is not clear and the effect of IL-35 on the function of Th17 cells is still incompletely understood. Therefore, we investigat

APA, Harvard, Vancouver, ISO und andere Zitierweisen

43

Matsuoka, Hiroshi, Miyu Katayama, Ami Ohishi та ін. "Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation". International Journal of Molecular Sciences 21, № 9 (2020): 3309. http://dx.doi.org/10.3390/ijms21093309.

Der volle Inhalt der Quelle

Annotation:

Oxysterols, important regulators of cholesterol homeostasis in the brain, are affected by neurodegenerative diseases. Early-onset Alzheimer’s disease is associated with higher levels of circulating brain-derived 24S-hydroxycholesterol (24S-OHC). Conversion of cholesterol to 24S-OHC is mediated by cholesterol 24S-hydroxylase in the brain, which is the major pathway for oxysterol elimination, followed by oxidation through hepatic first-pass metabolism by CYP39A1. Abnormal CYP39A1 expression results in accumulation of 24S-OHC, influencing neurodegenerative disease-related deterioration; thus, it

APA, Harvard, Vancouver, ISO und andere Zitierweisen

44

Lee, In Kyu, Hyerin Song, Hyerim Kim та ін. "RORα Regulates Cholesterol Metabolism of CD8+ T Cells for Anticancer Immunity". Cancers 12, № 7 (2020): 1733. http://dx.doi.org/10.3390/cancers12071733.

Der volle Inhalt der Quelle

Annotation:

Retinoic acid-related orphan receptor α (RORα) functions as a transcription factor for various biological processes, including circadian rhythm, inflammation, cancer, and lipid metabolism. Here, we demonstrate that RORα is crucial for maintaining cholesterol homeostasis in CD8+ T cells by attenuating NF-κB transcriptional activity. Cholesterol sulfate, the established natural agonist of RORα, exhibits cellular cytotoxicity on, and increased effector responses in, CD8+ T cells. Transcript analysis reveals that the suppression of RORα leads to the upregulation of NF-κB target genes in T cells. C

APA, Harvard, Vancouver, ISO und andere Zitierweisen

45

Oh, Se Kyu, Dongha Kim, Kyeongkyu Kim та ін. "RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis". Proceedings of the National Academy of Sciences 116, № 42 (2019): 21140–49. http://dx.doi.org/10.1073/pnas.1907595116.

Der volle Inhalt der Quelle

Annotation:

Retinoic acid-related orphan receptor α (RORα) functions as a transcription factor for various biological processes, including circadian rhythm, cancer, and metabolism. Here, we generate intestinal epithelial cell (IEC)-specific RORα-deficient (RORαΔIEC) mice and find that RORα is crucial for maintaining intestinal homeostasis by attenuating nuclear factor κB (NF-κB) transcriptional activity. RORαΔIEC mice exhibit excessive intestinal inflammation and highly activated inflammatory responses in the dextran sulfate sodium (DSS) mouse colitis model. Transcriptome analysis reveals that deletion of

APA, Harvard, Vancouver, ISO und andere Zitierweisen

46

Chuck, Jonathan, Avanti Puvvala, Sean Campbell та Laura Solt. "Elucidating the Transcriptional Role of the Nuclear Receptor RORα in CD8+ T Cell Memory vs Effector Cell Development". Journal of Immunology 212, № 1_Supplement (2024): 0227_4701. http://dx.doi.org/10.4049/jimmunol.212.supp.0227.4701.

Der volle Inhalt der Quelle

Annotation:

Abstract CD8+ T cells play a critical role in controlling viral infections and cancer and have the potential to be harnessed for the development of new therapeutic strategies. Defining the transcriptional regulatory networks that control CD8+ T cell differentiation and function is of great importance to achieve these goals. The retinoic acid receptor-related orphan receptor alpha (RORα), a member of the nuclear receptor superfamily of ligand-regulated transcription factors, has emerged as a potential transcriptional regulator of CD8+ T cell immunity. However, exactly how RORα functions in thes

APA, Harvard, Vancouver, ISO und andere Zitierweisen

47

Stapleton, Cliona M., Maisa Jaradat, Darlene Dixon та ін. "Enhanced susceptibility of staggerer (RORαsg/sg) mice to lipopolysaccharide-induced lung inflammation". American Journal of Physiology-Lung Cellular and Molecular Physiology 289, № 1 (2005): L144—L152. http://dx.doi.org/10.1152/ajplung.00348.2004.

Der volle Inhalt der Quelle

Annotation:

The retinoid-related orphan receptor α (RORα), a member of the ROR subfamily of nuclear receptors, has been implicated in the control of a number of physiological processes, including the regulation of several immune functions. To study the potential role of RORα in the regulation of innate immune responses in vivo, we analyzed the induction of airway inflammation in response to lipopolysaccharide (LPS) challenge in wild-type and staggerer (RORαsg/sg) mice, a natural mutant strain lacking RORα expression. Examination of hematoxylin and eosin-stained lung sections showed that RORαsg/sg mice dis

APA, Harvard, Vancouver, ISO und andere Zitierweisen

48

Wang, Xiaoshan, Ru Jia, Ke Chen, Jingjing Wang, Kai Jiang та Zhengguang Wang. "RORα and REV-ERBα are Associated With Clinicopathological Parameters and are Independent Biomarkers of Prognosis in Gastric Cancer". Technology in Cancer Research & Treatment 20 (січень 2021): 153303382110396. http://dx.doi.org/10.1177/15330338211039670.

Der volle Inhalt der Quelle

Annotation:

Retinoid-related orphan receptor alpha (RORα) and nuclear receptor subfamily 1 group D member 1 (REV-ERBα) play critical roles in many human cancers. Whether RORα and REV-ERBα expression levels are associated with clinical characteristics are poorly understood, and they may be independent predictors of overall survival (OS) and progression-free survival (PFS) in gastric cancer (GC). This study aimed to investigate the correlation of RORα and REV-ERBα expression levels with clinicopathological parameters, OS, and PFS in GC. Immunohistochemistry and quantitative reverse transcription-polymerase

APA, Harvard, Vancouver, ISO und andere Zitierweisen

49

Mao, Wei, Gaofeng Xiong, Yuanyuan Wu та ін. "RORα Suppresses Cancer-Associated Inflammation by Repressing Respiratory Complex I-Dependent ROS Generation". International Journal of Molecular Sciences 22, № 19 (2021): 10665. http://dx.doi.org/10.3390/ijms221910665.

Der volle Inhalt der Quelle

Annotation:

Breast cancer development is associated with macrophage infiltration and differentiation in the tumor microenvironment. Our previous study highlights the crucial function of reactive oxygen species (ROS) in enhancing macrophage infiltration during the disruption of mammary tissue polarity. However, the regulation of ROS and ROS-associated macrophage infiltration in breast cancer has not been fully determined. Previous studies identified retinoid orphan nuclear receptor alpha (RORα) as a potential tumor suppressor in human breast cancer. In the present study, we showed that retinoid orphan nucl

APA, Harvard, Vancouver, ISO und andere Zitierweisen

50

Dempsey, Laurie A. "RORα in Treg cells". Nature Immunology 19, № 6 (2018): 510. http://dx.doi.org/10.1038/s41590-018-0099-x.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Wir bieten Rabatte auf alle Premium-Pläne für Autoren, deren Werke in thematische Literatursammlungen aufgenommen wurden. Kontaktieren Sie uns, um einen einzigartigen Promo-Code zu erhalten!