Thematische Bibliographien / Serum cystatin C

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Auswahl der wissenschaftlichen Literatur zum Thema „Serum cystatin C“

Autor: Grafiati
Veröffentlicht am 4. Juni 2021
Zuletzt aktualisiert am 8. Februar 2022

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Zeitschriftenartikel zum Thema "Serum cystatin C"

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Al-Nasrawii, Maytham Salim, Balqees Sadoon Jasim und Salim Hussein Hassan. „A COMPARATIVE ASSESSMENT OF SERUM CREATININE AND CYSTATIN C AS A SIGNIFICANCE OF NEPHROPATHY IN DIABETIC PATIENTS“. Malaysian Journal of Public Health Medicine 20, Nr. 3 (31.12.2020): 189–94. http://dx.doi.org/10.37268/mjphm/vol.20/no.3/art.527.

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The critical micro-vascular complications of diabetes ultimately result in renal dysfunction known as diabetic nephropathy (DN). Measurement of glomerular filtration rate (GFR) is considered to be an important parameter in renal function assessment, evaluating GFR by Creatinine level. Recently, Cystatin C is used as a substitute indicator in several studies to assess diabetic nephropathy. This work was conceived to determine whether serum cystatinC would replace serum creatinine (Scr) in patients with type2 diabetes for early evaluation of nephropathy. A Case-Control Study was enrolled on 30 Patients with diabetic and 30 apparently healthy as control, aged between 25 - 83 years. Levels of serum cystatine C and serum Creatinine were calculated for both groups. Serum Creatinine, as well as serum cystatin C levels, was significant relationship with diabetic pt. in compared to non-diabetic individuals. ROC analysis noted the cystatinC was more predict indicator in diagnosed Diabetic Nephropathy (DNP) from Serum Creatinine level. In Type 2 diabetics, CystatinC is a good marker for uncontrolled diabetic nephropathy relative to serum creatinine.
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Al-Nasrawii, Maytham Salim, Balqees Sadoon Jasim und Salim Hussein Hassan. „A COMPARATIVE ASSESSMENT OF SERUM CREATININE AND CYSTATIN C AS A SIGNIFICANCE OF NEPHROPATHY IN DIABETIC PATIENTS“. Malaysian Journal of Public Health Medicine 20, Nr. 3 (31.12.2020): 189–94. http://dx.doi.org/10.37268/mjphm/vol.20/no.3/art.527.

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The critical micro-vascular complications of diabetes ultimately result in renal dysfunction known as diabetic nephropathy (DN). Measurement of glomerular filtration rate (GFR) is considered to be an important parameter in renal function assessment, evaluating GFR by Creatinine level. Recently, Cystatin C is used as a substitute indicator in several studies to assess diabetic nephropathy. This work was conceived to determine whether serum cystatinC would replace serum creatinine (Scr) in patients with type2 diabetes for early evaluation of nephropathy. A Case-Control Study was enrolled on 30 Patients with diabetic and 30 apparently healthy as control, aged between 25 - 83 years. Levels of serum cystatine C and serum Creatinine were calculated for both groups. Serum Creatinine, as well as serum cystatin C levels, was significant relationship with diabetic pt. in compared to non-diabetic individuals. ROC analysis noted the cystatinC was more predict indicator in diagnosed Diabetic Nephropathy (DNP) from Serum Creatinine level. In Type 2 diabetics, CystatinC is a good marker for uncontrolled diabetic nephropathy relative to serum creatinine.
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., Pusparini. „PERBANDINGAN CYSTATIN C DENGAN PARAMETER UJI FUNGSI GINJAL LAINNYA“. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 14, Nr. 1 (15.03.2018): 16. http://dx.doi.org/10.24293/ijcpml.v14i1.919.

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The Gold standard for the evaluation of the glomerular filtration rate (GFR) is inulin clearance, but in widespread use is prevented by several technical difficulties. The most commonly used marker for GFR is serum creatinine alone or in conjunction with 24 hoururine collection for determination of creatinine clearance, but these marker have several limitation include following: influence of age,sex, muscle mass on endogenous creatinine production, dietary intake and the difficulties of 24 hour urine collection. Fifty six patientwith chronic renal failure and 53 control had analyze for serum creatinin, creatinine clearance and serum cystatin C. The chronic renalfailure patient aged range from (64 + 14.54) year and the control group aged range from (62.5+ 17.5) year. The proposed of this studywas to compare cystatin C with another parameter for renal function test. The result showed that in control group serum creatinineand creatinine clearance had influence with age, sex and body mass index, but serum cystatin C was not. The normal value of cystatinC was (0.85 + 0.13) mg/dL In chronic renal failure group there were significant correlation between level of cystatin C with creatininclearance (p = 0.000, r = 0.69). The level of cystatin C increase higher than serum creatinine in patient with low clearance creatinine.In control group we were determined low creatinine clearance in patient with normal serum creatinine and cystatin C.
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Risch, Lorenz, und Andreas R. Huber. „Serum cystatin C in transplantation“. Kidney International 61, Nr. 4 (April 2002): 1548. http://dx.doi.org/10.1046/j.1523-1755.2002.00288.x.

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Gashenko, Elena A., V. A. Lebedeva, G. S. Russkikh, E. A. Tsykalenko, A. B. Pupyshev, I. V. Brak und T. A. Korolenko. „PROCATHEPSIN B AND ENDOGENOUS INHIBITORS OF CYSTEINE PROTEASES IN TUMORS OF REPRODUCTIVE SYSTEM“. Russian Journal of Oncology 22, Nr. 5 (15.10.2017): 261–65. http://dx.doi.org/10.18821/1028-9984-2017-22-5-261-265.

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Cysteine proteases are regulated by the rate of the conversion of their inactive proforms into active forms and by specific endogenous inhibitors (cystatins), playing the important role in their regulation, especially in tumor growth and metastasis process. The content of procatepsin B, endogenous inhibitors of cysteine proteases cystatin B and cystatin C in biological fluids (blood serum, ascites fluid) in women with malignant neoplasms of the genital organs was studied. The comparative study of the concentration of procotepsin B, cystatin B and C in blood serum in practically healthy women and women with tumors of the reproductive system was carried out with the use of the enzyme immunoassay nethod. A high content of procatepsin B was shown to be found in all the study groups. The concentration of cystatin B was within the limits of significance and concentration of cystatin C was not changed in same patients in the study groups as compared with the control. The level of cystatin C in the serum was found to be correlated with the progression of the disease. In ascitic fluid (in comparison with blood serum), a sharp increase in the concentration of procatepsin B was revealed, reflecting its elevated extracellular secretion by tumor cells.
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Meinardaniawati, Dinna, Sjarif Hidajat Effendi und Sri Endah Rahayuningsih. „Kadar Cystatin-C Serum Sebagai Penanda Fungsi Ginjal Bayi Prematur“. Sari Pediatri 15, Nr. 1 (16.11.2016): 17. http://dx.doi.org/10.14238/sp15.1.2013.17-22.

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Latar belakang. Cystatin-C dipertimbangkan menjadi pemeriksaan potensial pengganti kreatinin serum sebagai penanda fungsi ginjal. Kadar cystatin-C serum lebih mendekati nilai laju filtrasi glomerulus dibandingkan dengan kreatinin serum. Beberapa penelitian menyatakan bahwa cystatin-C dipengaruhi oleh jenis kelamin, usia, dan ras meskipun tidak sebesar pengaruhnya terhadap kreatinin.Tujuan. Menganalisis korelasi kadar cystatin-C serum dengan kreatinin serum dan apakah kadar cystatin-C serum dapat digunakan sebagai penanda fungsi ginjal bayi prematur.Metode. Penelitian observasional analitik, cross-sectional, dilaksanakan Februari−Mei 2012. Subjek adalah bayi prematur usia kehamilan 32–<37 minggu, lahir di Rumah Sakit Dr. Hasan Sadikin Bandung, RSUD Cibabat Cimahi, dan RSUD Bandung. Dilakukan pemeriksaan kadar cystatin-C serum dengan metode particle-enhanced immunonephelometry dan kreatinin serum dengan metode Jaffe. Uji statistik menggunakan korelasi Pearson, kemaknaan berdasarkan nilai p<0,05.Hasil. Terdapat 37 subjek bayi prematur, 23/37 subjek dilahirkan spontan dengan perbandingan jenis kelamin hampir sama. Kadar cystatin-C dan kreatinin serum rerata adalah 1,68 mg/L (IK 95%; 1,32–2,09) dan 0,99 mg/dL (IK 95%; 0,62–1,48). Hasil analisis mendapatkan korelasi bermakna kadar cystatin-C dengan kreatinin serum (r=0,621; p<0,001).Kesimpulan. Semakin tinggi kadar kreatinin serum, maka semakin tinggi kadar cystatin-C serum. Cystatin-C dipertimbangkan sebagai penanda untuk menilai fungsi ginjal bayi prematur.
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Elliyanti, Aisyah, Iskandar Iskandar und Syaiful Azmi. „CORRELATION OF RENOGRAM WITH CYSTATIN-C LEVELS AND CREATININE CLEARANCE IN MEASURING GLOMERULAR FILTRATION RATE“. Majalah Kedokteran Andalas 38, Nr. 1 (20.05.2015): 1. http://dx.doi.org/10.22338/mka.v38.i1.p1-6.2015.

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AbstrakRenogram 99mTc-DTPA (diethylenetriamine pentacetic acid) memiliki beberapa kelebihan dalam mengukur laju filtrasi glomerulus (LFG). Cystatin-c digunakan sebagai petanda biologik baru untuk memperkirakan LFG. Tujuan penelitian ini adalah untuk menentukan korelasi nilai LFG antara renogram dengan cystatin-c dan kliren kreatinin pada pasien dengan penyakit ginjal kronis (PGK). Subjek penelitian adalah pasien PGK stadium dua berdasarkan hasil estimasi LFG dengan rumus Cockroft-Gault. Pasien yang memenuhi kriteria diperiksa renogram, kadar kreatinin serum, cystatin-c dan klirens kreatinin.Rerata LFG dari 30 orang subjek yang diperiksa dengan renogram, cystatin-c, creatinine clearance, Cockroft-Gault’s formula berturut turut adalah 64.96 ml/min/1.73m2 (SD 28.047), 53.37 ml/min/1.73m2 (SD 21.29), 58.09 ml/min/1.73m2 (SD 35.45), 46.00 ml/min/1.73m2 (SD 12.06). Korelasi antara renogram dengan cystatin-c dengan nilai r = 0.585 dan p = 0.0007, antara renogram dengan klirens kreatinin dengan nilai r = 0.388 dan p = 0.03) dan antara renogram dengan rumus Cockroft-Gault’s dengan nilai r = -0.029 dan p=0.87. Pada penelitian ini didapatkan hasil korelasi yang lebih baik antara renogram dengan cystatin-c dari pada antara renogram dengan klirens kreatinin dan antara renogram dengan rumus Cockroft-Gault’s. Lebih lanjut, cystain-c merupakan alternatif yang lebih baik untuk memperkirakan LFG jika metode pemeriksaan LFG yang mendekati teknik pemeriksaan yang ideal tidak tersedia.AbstractRenogram using 99mTc-DTPA (diethylenetriamine pentacetic acid) has advantages in the measurement of glomerular filtration rate (GFR). Serum cystatin-c was recently projected to be the new marker of estimated GFR. The aim of this study is to establish correlation between GFRs, derived from renogram with cystatin-c levels and creatinine clearances in chronic kidney disease patients.We put to study thirty consecutive stage two of chronic kidney disease patients assigned based on GFR estimation by Cockroft-Gault’s formula, taking into account the serum creatinine. Cystatin-c and creatinine clearance were performed to determine of GFR and renogram was included in this study. A total of thirty subjects, the mean of GFRs were taken from renogram, cystatin-c, creatinine clearance, Cockroft-Gault’s formula were 64.96 ml/min/1.73m2 (SD 28.047), 53.37 ml/min/1.73m2 (SD 21.29), 58.09 ml/min/1.73m2 (SD 35.45), 46.00 ml/min/1.73m2 (SD 12.06) respectively. A correlation between renogram with cystatin-c (r = 0.585 and p = 0.0007) and renogram with creatinine clearance (r = 0.388 and p = 0.03) and renogram with Cockroft-Gault’s formula (r = -0.029 and p=0.87). This study has shown that a better correlation between renogram with cystatin-c than with creatinine clearance or Cockroft-Gault’s formula. Furthermore, cystain-c would be better alternative method incase having problems to obtain a closest ideal methods for GFR.
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Čabarkapa, Velibor, Zoran Stošić, Mirjana Đerić, Ljiljana Vučurević-Ristić, Radmila Žeravica und Branislava Ilinčić. „Serum Cystatin C in Estimating Glomerular Filtration Rate“. Journal of Medical Biochemistry 27, Nr. 1 (01.01.2008): 46–51. http://dx.doi.org/10.2478/v10011-007-0042-4.

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Serum Cystatin C in Estimating Glomerular Filtration RateUsing serum cystatin C in estimating glomerular filtration rate (GFR) has in recent times been recommended. A number of simple formulas for calculating GFR have been derived specifically from serum cystatin C concentrations. The purpose of this study was to assess the significance of cystatin C and of the two most frequently applied of these formulas in estimating glomerular filtration rate compared to serum creatinine and its derived formulas for estimating glomerular filtration rate from creatinine concentrations. The study included 74 patients: 59 were in various stages of chronic renal insufficiency (divided into two subgroups: I with GFR ≥ 60 mL/min/1.73m2and II with GFR<60 mL/min/1.73m2) and 15 on hemodialysis. A control group of 30 healthy participants was also included in the study. Serum values of cystatin C ranged from: 0.86 ± 0.16 mg/L in subgroup I, and 1.77 ± 0.79 mg/L in subgroup II, to 6.9 ± 1.83 mg/L in patients on hemodialysis. The correlation between the two formulas derived from cystatin C and the clearance of creatinine, as well as the Cockcroft and Gault's formula, was significant, while one of the formulas derived from cystatin C did not show a significant correlation with MDRD. It was concluded that serum cystatin C is a significant marker in estimating glomerular filtration rate, especially in the advanced stages of chronic renal insufficiency.
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Alvarez, Ofelia A., Dale Wright, Gabriela Lopez und Gaston Zilleruelo. „Serum Cystatin C Is a Better Marker for Renal Function Than Serum Creatinine in Children with Sickle Cell Disease.“ Blood 106, Nr. 11 (16.11.2005): 3774. http://dx.doi.org/10.1182/blood.v106.11.3774.3774.

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Abstract High serum creatinine is a late manifestation for patients (pts) with sickle cell disease (SCD) who develop severe renal dysfunction, because creatinine is secreted by the renal tubules. Serum cystatin C is a cysteine proteinase inhibitor, that is produced by all nucleated cells in the body, does not undergo tubular secretion, and reflects glomerular filtration rate (GFR)accurately. Normal levels for serum cystatin C are 0.5–1.3 mg/L for children 1–17 years, and 0.5–1 mg/L for adults. The purpose of this study was to compare serum cystatin C and serum creatinine as markers of GFR in children with SCD with different levels of albuminuria. Twenty pts (mean age 16.4, range 9–21 years) had serum creatinine, serum cystatin, and 24-hour urine for creatinine clearance. Pts with normoalbuminuria (N=11) had mean serum creatinine of 0.55±0.14 mg/L, creatinine clearance of 168±36 ml/min/1.73m2, normal serum cystatin C 0.78±0.16 mg/L, and normal estimated GFR derived from cystatin of 106±27 ml/min/1.73m2. In contrast, pts with proteinuria (N=4) had higher or abnormal serum cystatin C (mean 1.25 ±0.34, range 0.9–1.7 mg/L) and reduced estimated GFR (mean 59±21, range 35–85) consistent with poor kidney function; nevertheless, the serum creatinine (0.7±0.2) and creatinine clearance remained normal (125±27). Pts with only microalbuminuria (N=5) maintained normal levels of cystatin C and estimated GFR by cystatin. We conclude that serum cystatin C discriminated better for kidney dysfunction than serum creatinine and creatinine clearance with significantly different values between patients with normoalbuminuria and macroalbuminuria (p=0.038). More studies are warranted in order to investigate further the value of serum cystatin C in the monitoring of patients with SCD and albuminuria.
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Ogawa, Yoshiji, Takashi Goto, Naoki Tamasawa, Jun Matsui, Yusuke Tando, Kazuhiro Sugimoto, Ken Tomotsune, Masahiko Kimura, Minoru Yasujima und Toshihiro Suda. „Serum cystatin C in diabetic patients“. Diabetes Research and Clinical Practice 79, Nr. 2 (Februar 2008): 357–61. http://dx.doi.org/10.1016/j.diabres.2007.09.016.

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Dissertationen zum Thema "Serum cystatin C"

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Berglund, Linnea, und Sara Lundin. „En sammanställning av kreatinin och cystatin C vid skattning av glomerulär filtrationshastighet : En litteraturöversikt“. Thesis, Luleå tekniska universitet, Institutionen för hälsovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-60883.

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Inledning: Undersökningar som inkluderar kontrastmedel har ökat på datortomografin (DT). Inför kontrastmedelsundersökningar ska den glomerulära filtrationshastigheten (GFR) estimeras för att få ett mått på patientens njurfunktion. I nuläget finns det två olika markörer som kan användas till detta, kreatinin och cystatin C. Det är röntgensjuksköterskans ansvar att skatta GFR för att kunna göra en bedömning om patienten kan utföra undersökningen. Syfte: Syftet med studien var att sammanställa studier som jämför kreatinin och cystatin C vid skattning av GFR. Metod: Den här studien genomfördes som en allmän litteraturöversikt. Litteratursökningen genomfördes i databaserna CINAHL, PubMed och SveMed+. Tio kvantitativa vetenskapliga artiklar lokaliserades och gick vidare till analys. Resultat: Resultatet visade att cystatin C i många fall var en bättre indikator för att estimera GFR. Slutsats: För äldre och njursjuka ansågs cystatin C vara en bättre markör för njurfunktionen. Dock anser författarna att det krävs vidare forskning inom ämnet och dess påverkande faktorer för att kunna introducera cystatin C som ny njurfunktionsmarkör.
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Kaiser, Tiffany E. „An Appropriate Assessment of Kidney Function In Patients with End Stage Liver Disease: Role of Cystatin C“. University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396532967.

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Zhao, Jie, Wuquan Deng, Yuping Zhang, Yanling Zheng, Lina Zhou, Johnson Boey, David G. Armstrong, Gangyi Yang, Ziwen Liang und Bing Chen. „Association between Serum Cystatin C and Diabetic Foot Ulceration in Patients with Type 2 Diabetes: A Cross-Sectional Study“. HINDAWI PUBLISHING CORP, 2016. http://hdl.handle.net/10150/621722.

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Serum cystatin C (CysC) has been identified as a possible potential biomarker in a variety of diabetic complications, including diabetic peripheral neuropathy and peripheral artery disease. We aimed to examine the association between CysC and diabetic foot ulceration (DFU) in patients with type 2 diabetes (T2D). 411 patients with T2D were enrolled in this cross-sectional study at a university hospital. Clinical manifestations and biochemical parameters were compared between DFU group and non-DFU group. The association between serum CysC and DFU was explored by binary logistic regression analysis. The cut point of CysC for DFU was also evaluated by receiver operating characteristic (ROC) curve. The prevalence of coronary artery disease, diabetic nephropathy (DN), and DFU dramatically increased with CysC ( P < 0.01 ) in CysC quartiles. Multivariate logistic regression analysis indicated that the significant risk factors for DFU were serum CysC, coronary artery disease, hypertension, insulin use, the differences between supine and sitting TcPO 2 , and hypertension. ROC curve analysis revealed that the cut point of CysC for DFU was 0.735 mg/L. Serum CysC levels correlated with DFU and severity of tissue loss. Our study results indicated that serum CysC was associated with a high prevalence of DFU in Chinese T2D subjects.
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Kühnel, Markus. „Diagnostische Wertigkeit der fraktionellen Harnstoffexkretion, des Serum Cystatin C, sowie der glomerulären Filtrationsrate nach MDRD zur Detektion eines hepatorenalen Syndroms bei Leberzirrhose“. kostenfrei, 2008. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1127/.

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Haghgu, Mojgan [Verfasser], Christoph [Akademischer Betreuer] Kramm, Dirk [Akademischer Betreuer] Vordermark und Dominik [Akademischer Betreuer] Schneider. „Korrelation des Serum-Cystatin C mit der endogenen Kreatinin-Clearance zur Einschätzung der Nierenfunktion bei Kindern und Jugendlichen mit onkologischen Erkrankungen / Mojgan Haghgu. Betreuer: Christoph Kramm ; Dirk Vordermark ; Dominik Schneider“. Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2015. http://d-nb.info/1089085184/34.

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Ziegelasch, Niels. „Cystatin C serum levels in healthy children are related to age, gender and pubertal stage“. 2019. https://ul.qucosa.de/id/qucosa%3A36268.

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Background. This study aims to establish age- and gender-specific cystatin C (CysC) reference values for healthy infants, children, and adolescents and to relate them to pubertal stage, height, weight, and body mass index (BMI). Methods. Serum CysC and creatinine levels of 6217 fasting, morning venous blood samples from 2803 healthy participants of the LIFE Child study (age 3 months to 18 years) were analyzed by an immunoassay. Recruitment started in 2011; 1636 participants provided at least one follow-up measurement. Percentiles for CysC were calculated. Age- and gender-related effects of height, weight, BMI, and puberty status were assessed through linear regression models. Results. Over the first 2 years of life, median CysC levels decrease depending on height (ß = − 0.010 mg/l/cm, p < 0.001) and weight (ß = − 0.033 mg/l/kg, p < 0.001) from 1.06 to 0.88 mg/l for males and from 1.04 to 0.87 mg/l for females. Following the second year of age, the levels remain stable for eight years. From 11 to 14 years of age, there is an increase of median CysC levels in males to 0.98 mg/l and a decrease in females to 0.86 mg/l. The change is associated with puberty (ß = 0.105 mg/l/Tanner stage, p < 0.001 in males and ß = − 0.093 mg/l/Tanner stage, p < 0.01 in females) and in males with height (ß = 0.003 mg/l/cm, p < 0.001). Conclusions. CysC levels depend on age, gender, and height, especially during infancy and puberty. We recommend the use of age- and gender-specific reference values for CysC serum levels for estimating kidney function in clinical practice.:1 Contents ........................................................................................................... 1 2 Introduction ...................................................................................................... 2 GFR measurement ............................................................................................. 2 Technically advanced methods ........................................................................ 2 Serum creatinine................................................................................................ 3 Serum Cystatin C............................................................................................... 3 Current state of research..................................................................................... 5 Reference values of Cystatin C ......................................................................... 5 Cystatin C in healthy test persons .................................................................... 6 Validity of Cystatin C for kidney diseases.......................................................... 6 Post-transplant validity of Cystatin C ............................................................... 7 Validity of Cystatin C in extra-renal diseases .................................................... 7 GFR-equations................................................................................................... 8 Confounders ...................................................................................................... 9 Relevance of the topic ......................................................................................... 11 Hypothesis ........................................................................................................... 13 3 Publication – manuscript................................................................................... 14 4 Summary and interpretation ............................................................................. 16 5 References ........................................................................................................ 20 6 Appendix ........................................................................................................... I 7 Description of the own contributions ................................................................ VII 8 Erklärung über die eigenständige Abfassung der Arbeit .................................. VIII 9 Curriculum vitae ................................................................................................ IX 10 Scientific publications and presentations ....................................................... XI 11 Acknowledgements.......................................................................................... XII
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Mei-Tai und 胡美黛. „Application of serum cystatin C for evaluation the influence of different medicines on kidney function in type 2 diabetes patient“. Thesis, 2011. http://ndltd.ncl.edu.tw/handle/40506885796728460719.

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碩士
中山醫學大學
生化暨生物科技研究所
99
Diabetic nephropathy is the most common complication of diabetes and cause of death. Studies showed that serum cystatin C has higher sensitivity for detection of early diabetic nephropathy than serum creatinine or serum creatinine base formula for calculated eGFR1,2. There are little literatures investigating the relationship between drug utilization and early diabetic nephropathy. The impact of variety of drugs on early diabetic nephropathy is not clear. This study used serum cystatin C to evaluation the impact of hypoglycemic drugs or lowering high blood pressure drugs on early diabetic nephropathy in 125 type II diabetes patients. Serum level of cystatin C was determined by immune nephelometry assay and used for calculation of Cys-eGFR. Usual blood data such as glycosylated hemoglobin, kidney function and blood lipids and body mass index were collected for analysis. The results showed that Cys-eGFR, urinary albumin creatinine ratio and high-density lipoprotein were lower in male than in female. On the other hand serum creatinine and serum cystatin C (p = 0.01) were significant higher in male than in female. The age of patients was positively correlated to serum cystatin C (r = 0.531, p &lt;0.001), and negatively correlated to Cys-eGFR (r = 0.549, p &lt;0.001). The users of sulfonylurea class drug, glibenclamide, and blood pressure lowering drugs of beta blocker class (β1-blocker) had lower Cys-eGFR as compared to those using other types of drugs with significances of P = 0.003 and P = 0.001 respectively. Application serum cystatin C for calculation of glomerular filtration rate (Cys-eGFR) for screening of kidney function in diabetic patients should be able to provide early warning sign of initial renal dysfunction for those drug users at high risk.
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Weidling, Heike. „Vergleich der nach Cockcroft und Gault berechneten Kreatinin-Clearance mit der nuklearmedizinischen MAG3-Clearance und mit den Konzentrationen von Cystatin C im Serum unter Routinebedingungen /“. 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012848037&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Kühnel, Markus [Verfasser]. „Diagnostische Wertigkeit der fraktionellen Harnstoffexkretion, des Serum Cystatin C, sowie der glomerulären Filtrationsrate nach MDRD zur Detektion eines hepatorenalen Syndroms bei Leberzirrhose / vorgelegt von Markus Kühnel“. 2009. http://d-nb.info/992296498/34.

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Bühren, Katharina [Verfasser]. „Inzidenz und Risikoprädiktion der Kontrastmittelnephropathie bei Patienten mit grenzwertiger Nierenfunktion : Evaluation von Cystatin C im Serum im Rahmen einer prospektiven Studie an je 200 Patienten mit intravenöser bzw. intraarterieller Kontrastmittelapplikation / Katharina Bühren“. 2007. http://d-nb.info/985168846/34.

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Bücher zum Thema "Serum cystatin C"

1

Palevsky, Paul M. Monitoring renal function in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0209.

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Renal function needs to be monitored in critically-ill patients to detect changes in glomerular filtration rate (GFR) and promptly diagnosis acute kidney injury (AKI). In the absence of reliable bedside techniques for the assessment of GFR, continuous monitoring of urine output and frequent assessment of serum creatinine levels remain the cornerstone of renal functional monitoring. Calculated estimations of GFR should not be relied upon in critically-ill patients, particularly if kidney function is not stable. The role of serum cystatin C as a marker of GFR and biomarkers of tubular injury in routine monitoring of kidney function is uncertain.
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Speeckaert, Marijn, und Jopis Delanghe. Assessment of renal function. Herausgegeben von Christopher G. Winearls. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0007.

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Glomerular filtration rate (GFR) can be measured as the clearance of exogenous or endogenous filtration markers. Practical formulas permit estimation of creatinine clearance or GFR without timed urine collections in many stable patients with CKD. Standardization of serum creatinine is important for all of these estimation methods and implementing traceability of the assays to the new global SRM 967 standard has led to changes in clinical decision-making criteria. Calibration to an IDMS reference produces a lowering of serum creatinine values by 10–30% for most methods. Serum creatinine concentration depends on age, gender and muscle mass. Cystatin C is an alternative marker of GFR, but estimation is more expensive and it is not clear that it has a useful place in routine practice. The MDRD Study equation was validated in the framework of the Modification of Diet in Renal Diseases study. It is superior to the Cockcroft and Gault formula for estimating Creatinine Clearance in most people. In 2009, the CKD Epidemiology Collaboration (CKD-EPI) formula was introduced, which provides a more accurate estimation for patients with GFR values between 60 and 90 mL/min. In children, the Schwartz formula is frequently used. Some urinary markers of kidney disease are also discussed.
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Plebani, Mario, Monica Maria Mion und Martina Zaninotto. Biomarkers of renal and hepatic failure. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0039.

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In the last few years, major advances have been achieved in the understanding of the molecular and pathophysiological mechanisms which underlie the complex interactions between the heart and the kidney, as well as between the heart and the liver. According to these new insights, new biomarkers have been proposed for better evaluating and monitoring patients affected by cardiovascular diseases. In addition, some biomarkers should be used as risk factors and for an early identification and treatment of these severe diseases. This chapter reviews the most important biomarkers for evaluating the ‘cardiorenal syndrome’, in particular, the measurement of serum creatinine and its use for calculating the glomerular filtration rate which, with the new and more efficient equation, namely Chronic Kidney Disease Epidemiology Collaboration, still remains the most widely used biomarker. The role of newer biomarkers will be explored. The measurement of cystatin C, representing additional information, particularly in paediatric age groups and in the early phase of kidney disease, plays an increasing role. Neutrophil gelatinase-associated lipocalin is a recently developed and very promising new biomarker for the diagnosis of acute kidney injury, while the well-known albumin/creatinine ratio has been re-evaluated as a simple and useful tool for an early identification of kidney disease. Regarding liver diseases, a growing body of evidence demonstrates the usefulness of non-invasive makers of hepatic fibrosis that may avoid the need for a liver biopsy in most patients. A promising field of research is represented by the role of non-alcoholic fatty liver disease in the pathogenesis of cardiovascular disease.
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Buchteile zum Thema "Serum cystatin C"

1

Tomino, Y. „Serum Cystatin C“. In Contributions to Nephrology, 82–84. Basel: KARGER, 2001. http://dx.doi.org/10.1159/000060137.

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Çuhadar, Serap. „Serum Cystatin C as a Biomarker“. In Biomarkers in Kidney Disease, 1–17. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-007-7743-9_20-1.

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Çuhadar, Serap. „Serum Cystatin C as a Biomarker“. In Biomarkers in Kidney Disease, 445–61. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-007-7699-9_20.

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Cattaneo, A., J. L. Sansot, D. Prevot, C. Blanc, Y. Manuel und A. Colle. „Cystatin C (Post γ Globulin) in serum from patients with autoimmune diseases“. In Cysteine Proteinases and their Inhibitors, herausgegeben von Vito Turk, 507–16. Berlin, Boston: De Gruyter, 1986. http://dx.doi.org/10.1515/9783110846836-046.

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Nguyen, Timothy, Tran Tran und Thomas Dowling. „Principles of Drug Therapy in Reduced Kidney Function“. In Kidney Protection, herausgegeben von Vijay Lapsia, Bernard G. Jaar und A. Ahsan Ejaz, 211–18. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190611620.003.0021.

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The prevalence of kidney disease is high. Most drugs are excreted by the kidneys and drug dosage adjustments are likely required in renal impairment to avoid accumulation and exposure-related toxicity. Kidney disease affects physiological changes and alterations in the pharmacokinetics and the pharmacodynamics of many drugs. Glomerular filtration rate is considered the best overall index of kidney function. Kidney function can be assessed by using endogenous and exogenous markers such as serum creatinine, inulin, cystatin C, radionuclide-labeled, estimated equations for creatinine clearance such as Cockcroft-Gault, and estimated equations for GFR such as the Modification of Diet in Renal Disease study equation, and the Chronic Kidney Disease Epidemiology Collaboration Epidemiology study equation. Applying good prescribing practice is important for limiting drug toxicities and improving patient care.
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6

Plebani, Mario, Monica Maria Mion und Martina Zaninotto. „Biomarkers of renal and hepatic failure“. In The ESC Textbook of Intensive and Acute Cardiovascular Care, herausgegeben von Marco Tubaro, Pascal Vranckx, Eric Bonnefoy-Cudraz, Susanna Price und Christiaan Vrints, 434–44. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198849346.003.0036.

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In the last years, major advances have been achieved in the understanding of the molecular and pathophysiological mechanisms which underlie the complex interactions between the heart and the kidney, as well as between the heart and the liver. According to these new insights, innovative biomarkers have been proposed for better evaluating and monitoring patients affected by cardiovascular diseases. In addition, some biomarkers should be used as risk factors and for an early identification and treatment of these severe diseases. This chapter reviews the most important biomarkers for evaluating the 'cardiorenal syndrome', in particular, the measurement of serum creatinine and its use for calculating the glomerular filtration rate which, with the new and more efficient equation, namely Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), still remains the most widely used biomarker. The role of newer biomarkers will be explored. The measurement of cystatin C, representing additional information, particularly in paediatric age groups and in the early phase of kidney disease, plays an increasing role. Neutrophil gelatinase-associated lipocalin (NGAL) is a recently developed but largely used biomarker for the early diagnosis of acute kidney injury, while the well-known albumin/creatinine ratio has been re-evaluated as a simple and useful tool for an early identification of kidney disease. Regarding liver diseases, a growing body of evidence demonstrates the usefulness of non-invasive makers of hepatic fibrosis that may avoid the need for a liver biopsy in most patients. A promising field of research is represented by the role of non-alcoholic fatty liver disease in the pathogenesis of cardiovascular disease.
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7

Park, Kyung-Sun, Soo-Kyung Kim, Seok-Won Park und Yong-Wook Cho. „Serum Cystatin C as Well as Urinary Albumin-Creatinine Ratio Is Associated with Carotid Artery Intima-Media Thickness (IMT) in Korean Type 2 Diabetic Patients“. In CLINICAL - Diabetes: Cardiometabolic Risk, P2–568—P2–568. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part3.p7.p2-568.

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Konferenzberichte zum Thema "Serum cystatin C"

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Amado Diago, Carlos Antonio, Mayte Garcia-Unzueta, Milagros Ruiz De Infante, Bernardo Alio Lavin, Raúl Armando Guerra, Juan Agüero, Beatriz Abascal et al. „Glomerular filtration rate estimated using serum creatinine and cystatin c, and Creatinine Cleareance measured in COPD patients“. In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4339.

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Yoshii, Ichiro, Tatsumi Chijiwa und Naoya Sawada. „AB0859 THE SERUM CREATININE TO CYSTATIN C RATIO; A POSSIBLE NEW SURROGATE MARKER FOR BONE MINERAL DENSITY“. In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.910.

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Li, Ya. „Study of clinical characteristics, serum levels of cystatin C and treadmill exercise testing feather of walk-through angina“. In International Conference on Medical Engineering and Bioinformatics. Southampton, UK: WIT Press, 2014. http://dx.doi.org/10.2495/meb140591.

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Panholzer, B., M. Wegner, P. Oldenburg, K. Pilarczyk, K. Huenges, M. Salem, J. Cremer und A. Haneya. „Preoperative Serum Cystatin C as a Predictor of Acute Kidney Injury after Thoracic Aortic Surgery with Deep Hypothermic Circulatory Arrest“. In 48th Annual Meeting German Society for Thoracic, Cardiac, and Vascular Surgery. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1678850.

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Marfianti, Erlina, und Auliya Nisa. „Effects of Serum Cystatin C Levels on Increased Systolic and Diastolic Blood Pressure in the Elderly With Normal Renal Function“. In 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020). Paris, France: Atlantis Press, 2021. http://dx.doi.org/10.2991/ahsr.k.210115.009.

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Nowinski, Adam, Anna Czyzak-Gradkowska, Damian Korzybski, Luiza Jonczak, Przemyslaw Bielen, Robert Plywaczewski und Pawel Sliwinski. „Obstructive sleep apnea and the risk of chronic kidney disease – glomerular filtration rate estimations based on serum cystatin C and creatinine concentrations“. In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa2329.

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