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Thematische Bibliographien / Structural cell model / Dissertationen

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Dissertationen zum Thema „Structural cell model“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Dennison, Kelly J. "Development of a structural model of human T-cell leukemia virus type-I protease." Thesis, Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/30060.

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2

Granja, Vasquez Jochen. "Analysis of Secreted Phosphoprotein-24 and its Effects During Osteoblast Differentiation in a Mesenchymal Stem Cell Model." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1884.

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Musculoskeletal diseases, in particular osteoporosis, are increasingly becoming more prevalent in the U.S. due to the ageing population (Figure1). It is estimated that one-sixth of 300 million people in U.S. suffer from bone disorders or loss. About 10 million of those people above age 50 suffer from osteoporosis. Patients that suffer from osteoporosis have high morbidity and mortality rates. For instance, patients have decreased bone mineral density (BMD), a measurement of bone density that reflects the strength of bone as represented by calcium content. A decrease in BMD typically leads

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Maluš, Miroslav. "Komplexní model turbulence pro různé velikosti cel." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442416.

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This diploma thesis is about creating a program to model turbulent cells of different sizes on the chosen transmission path. The initial part of the work is devoted to the formation of atmospheric turbulence and the mathematical description of the extent of turbulence and its effect on optical waves. The methods of the turbulence generation and their physical description of formation are described below. The practical part is devoted to the created program in the MATLAB.

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Santana, Bonilla Alejandro, Rafael Gutierrez, Sandonas Leonardo Medrano, Daijiro Nozaki, Alessandro Paolo Bramanti, and Gianaurelio Cuniberti. "Structural distortions in molecular-based quantum cellular automata: a minimal model based study." Royal Society of Chemistry, 2014. https://tud.qucosa.de/id/qucosa%3A36371.

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Molecular-based quantum cellular automata (m-QCA), as an extension of quantum-dot QCAs, offer a novel alternative in which binary information can be encoded in the molecular charge configuration of a cell and propagated via nearest-neighbor Coulombic cell–cell interactions. Appropriate functionality of m-QCAs involves a complex relationship between quantum mechanical effects, such as electron transfer processes within the molecular building blocks, and electrostatic interactions between cells. The influence of structural distortions of single m-QCA are addressed in this paper within a minimal

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Minassian, Anuka [Verfasser], and Peter [Gutachter] Kloppenburg. "Stem Cell Therapy For Stroke. Modulation of structural and functional adjustments after stem cell implantation in a mouse model of cortical stroke / Anuka Minassian ; Gutachter: Peter Kloppenburg." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/1200096991/34.

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6

Börsum, Jakob. "Estimating Causal Effects Of Relapse Treatment On The Risk For Acute Myocardial Infarction Among Patients With Diffuse Large B-Cell Lymphoma." Thesis, Uppsala universitet, Statistiska institutionen, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447241.

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This empirical register study intends to estimate average causal effects of relapse treatment on the risk for acute myocardial infarction (AMI) among patients with Diffuse B-Cell Lymphoma (DLBCL) within the potential outcome framework. The report includes a brief introduction to causal inference and survival anal- ysis and mentions specific causal parameters of interest that will be estimated. A cohort of 2887 Swedish DLBCL patients between 2007 and 2014 were included in the study where 560 patients suffered a relapse. The relapse treatment is hypothesised to be cardiotoxic and induces an incr

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Mason, Nena Lundgreen. "The Anatomy of Porcine and Human Larynges: Structural Analysis and High Resolution Magnetic Resonance Imaging of the Recurrent Laryngeal Nerve." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5783.

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The recurrent laryngeal nerve (RLN) innervates all the intrinsic muscles of the larynx that are responsible for human vocalization and language. The RLN runs along the tracheoesophageal groove bilaterally and is often accidentally damaged or transected during head and neck surgical procedures. RLN palsy and vocal cord paralysis are the most common and serious post op complications of thyroid surgeries. Patients who suffer from RLN injury can develop unilateral or bilateral vocal fold paralysis (BVFP). Theoretically, selective reinnervation of the posterior cricoarytenoid muscle would be the be

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Silparasetty, Shobha Lavanya. "Cloning of "Animal Cryptochrome" cDNA from the Model Organism CHLAMYDOMONAS REINHARDTII for Functional Analysis of Its Protein Product." TopSCHOLAR®, 2009. http://digitalcommons.wku.edu/theses/117.

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reinhardtii, a unicellular green alga, is a model organism to study the circadian clock. Cryptochromes are the blue light photoreceptors that entrain the clock in some organisms. The CPH1 protein of C. reinhardtii resembles the cryptochromes of the plant model Arabidopsis, but whether CPH1 entrains the circadian clock in C. reinhardtii is not yet known. Recent reports have suggested the existence of one more cryptochrome in C. reinhardtii, which resembles the cryptochromes of animals. However, the amino acid sequence of this protein shows even higher sequence similarity with the 6-4 DNA photol

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Orlová, Lucie. "Výpočtové modelování mechanických zkoušek živočišné buňky." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-443747.

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Předkládaná diplomová práce se zabývá stavbou živých živočišných buněk a jejich odezvou na mechanické zatěžování. Zobecněným zaměřením práce je popis mechanického chování buňky nejenom ve fyziologickém, ale i v patologickém stavu. Výchozím předpokladem pro úspěšné řešení zadané úlohy je vysoce interdisciplinární přístup kombinující výpočtové přístupy mechaniky těles (v~tomto případě metodu konečných prvků) s lékařským výzkumem. Nejdůležitějším bodem při tvorbě výpočtového modelu, pomocí něhož je možné aproximovat chování živé buňky při zatížení, je zejména identifikace mechanicky významných ko

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Yamamoto, Akihisa. "Mesoscopic structural dynamics and mechanics of cell membrane models." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/198928.

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11

Borges, Rutz Ricardo. "Mathematical models of physiologically structured cell populations." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/96187.

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En aquesta tesi es té en compte un model no lineal de creixement de població de cèl·lules que s'estructuren pel seu contingut de ciclina i cinases depenents de ciclina (CDK). Aquest model condueix a un sistema no lineal d'equacions en derivades parcials de primer ordre amb termes no locals. Per estudiar aquest sistema utilitzem la teoria de semigrups lineals positius i la formulació semilineal, que són eines molt poderoses per fer front a l'anàlisi d'aquest tipus de models, tant des del punt de vista del problema de valor inicial, com de l'existència i l'estabilitat d'estats estacionaris. E

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Al-wattar, Tahseen Abdulridha Ali. "Developing equivalent solid model for lattice cell structure using numerical approaches." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1610335304435815.

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13

Shaw, Alexander George. "Developing models of the mammalian cell S phase." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/developing-models-of-the-mammalian-cell-s-phase(3df7caaf-fd64-4bd2-b500-802f1a2c8ce2).html.

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The accurate replication of the mammalian genome is a complex and logistically challenging process. The entirety of the genome must undergo a single duplication with as little error as possible. This must occur in a coordinated fashion and over suitably short time scale so as to allow timely cellular division within a cell cycle that is typically around 24 hours in a human cell. A great wealth of knowledge already exists describing various aspects of the S phase, during which this replication of the genome occurs. This data has been gathered over a variety of model systems, ranging from infere

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14

Ye, Zhou. "Effect of Nanoscale Surface Structures on Microbe-Surface Interactions." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/85387.

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Bacteria in nature predominantly grow as biofilms on living and non-living surfaces. The development of biofilms on non-living surfaces is significantly affected by the surface micro/nano topography. The main goal of this dissertation is to study the interaction between microorganisms and nanopatterned surfaces. In order to engineer the surface with well-defined and repeatable nanoscale structures, a new, versatile and scalable nanofabrication method, termed Spun-Wrapped Aligned Nanofiber lithography (SWAN lithography) was developed. This technique enables high throughput fabrication of micro

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Cruickshank, Mark. "Analysis of CR2/CD21 transcriptional regulation by chromatin structural variation and notch activity in human cell models." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0115.

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[Truncated abstract] Human complement receptor 2 (CR2/CD21) is a cell surface glycoprotein detected on specific cells involved in immunity, which binds complement C3 cleavage fragments, cellular ligands IFN-? and CD23 as well as the EBV coat protein, gp350/220. During the early stages of B-cell development CR2/CD21 is silenced. Expression is initiated on immature B-cells escaping negative selection. During peripheral maturation CR2/CD21 is up-regulated with B-cell sub-populations showing distinctive surface levels (comparatively low, intermediate or high). CR2/CD21 is silenced upon terminal pl

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Callow, Philip Austin. "Cationic lipid : DNA complexes - their structure and interactions with model cell membranes." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400591.

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17

Daukste, Liene. "Mathematical Modelling of Cancer Cell Population Dynamics." Thesis, University of Canterbury. Department of Mathematics and Statistics, 2012. http://hdl.handle.net/10092/10057.

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Mathematical models, that depict the dynamics of a cancer cell population growing out of the human body (in vitro) in unconstrained microenvironment conditions, are considered in this thesis. Cancer cells in vitro grow and divide much faster than cancer cells in the human body, therefore, the effects of various cancer treatments applied to them can be identified much faster. These cell populations, when not exposed to any cancer treatment, exhibit exponential growth that we refer to as the balanced exponential growth (BEG) state. This observation has led to several effective methods of estimat

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18

Xiao, Long. "A structural micromechanical model of large deformation behavior of red blood cells." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1458440.

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19

Magzoub, Mazin. "Cell-penetrating peptides in model membrane systems : interaction, structure induction and membrane effects /." Stockholm : Institutionen för biokemi och biofysik, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-247.

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20

Williams, Katherine Spring. "Anti-Cancer Treatment and the Cell Cycle: Cellular-Level Mathematical Models." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/613282.

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This dissertation presents a collection of mathematical models for cellular response to the most common forms of anti-cancer therapy (radiation and chemotherapy) and the role of the cell cycle in this response. These models have application to improving cancer therapy through: optimization of dose and scheduling of agents already in clinical use; better predictive methods for selecting the most promising among new drug candidates or candidate combinations; and combination therapy with newer agents that target the cell cycle or cellular metabolism. The cellular pharmacodynamic models are base

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Krbálek, Jaroslav. "Určování elastických parametrů pro modely izolovaných buněk." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-229369.

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This diploma thesis focuses on computational modeling of the cell mechanical tests. The goal of this thesis is to build a cell model and to simulate compression test on this model. If necessary, the model should be adjusted so the model reflects real cell behavior. It was created the cell model reflecting cytoplasm, nucleus, membrane and cell cytoskeleton. Cytoskeleton was modeled as tensegrity structure. After this, the pressure test was simulated on this model. The behavior of the cell model and real cell was compared using the stress force. The stress force - cell deformation curve was mark

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22

Reynolds, Catherine Jane. "T cell receptor structure and cytokine responses in lung targeted inflammatory models." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/11884.

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23

Redfearn, James C. "A Comprehensive Model of the Structure and Function of the FtsZ Ring of Escherichia coli." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1460475643.

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24

林德華 and Tak-wah Lam. "Topological data structure and algorithms for cell-complex based non-manifold form feature modeling." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B3121244X.

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Lam, Tak-wah. "Topological data structure and algorithms for cell-complex based non-manifold form feature modeling /." Hong Kong : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19672214.

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26

KC, Rabi. "Study of Some Biologically Relevant Dynamical System Models: (In)stability Regions of Cyclic Solutions in Cell Cycle Population Structure Model Under Negative Feedback and Random Connectivities in Multitype Neuronal Network Models." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou16049254273607.

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27

Zhao, Lingyin. "Generalized Frequency Plane Model of Integrated Electromagnetic Power Passives." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/27692.

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The challenge to put power electronics on the same cost reduction spiral as integrated signal electronics has yet to be met. In the ongoing work for achieving complete power electronic converter integration, it has proven to be essential to develop a technology for integration of electromagnetic power passives. This integration will enable the incorporation of resonant circuits, transformers, EMI filters and the like into the integrated power electronics modules. These integrated electromagnetic power passives have been realized in terms of distributed structures, utilizing magnetic layers, co

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Costa, Veronica. "CHANGES IN MITOCHONDRIAL CRISTAE STRUCTURE DETERMINE CELL VIABILITY IN MODELS OF HUNTINGTON'S DISEASE." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3422375.

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Mitochondria are essential organelles for the life of the cells since they are the major source of cellular ATP (Danial et al., 2003), they regulate Ca2+ signalling (Rizzuto et al., 2000) and programmed cell death (Green and Kroemer, 2004). Mitochondria amplify the intrinsic apoptotic pathway by releasing protein cofactors, like cytochrome c, that are crucial for the activation of effector caspases required for cell demise. The majority of cytochrome c and the other components of the respiratory chain are restricted in the cristae compartment. Thanks to the development of 3D electron microscop

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Rosich, Oliva Albert. "Sensor placement for fault diagnosis based on structural models: application to a fuel cell stak system." Doctoral thesis, Universitat Politècnica de Catalunya, 2011. http://hdl.handle.net/10803/53635.

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The present work aims to increase the diagnosis systems capabilities by choosing the location of sensors in the process. Therefore, appropriate sensor location will lead to better diagnosis performance and implementation easiness. The work is based on structural models ands some simplifications are considered in order to only focus on the sensor placement analysis. Several approaches are studied to solve the sensor placement problem. All of them find the optimal sensor configuration. The sensor placement techniques are applied to a fuel cell stack system. The model used to describe the b

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Clark, Francis. "A computational study of gene structure and splicing in model eukaryote organisms /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17395.pdf.

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Garvey, Cathryn E. "Cloning, Expression, and Characterization of Ara h 3, a Major Peanut Allergen." ScholarWorks@UNO, 2012. http://scholarworks.uno.edu/td/1565.

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Abstract There are eight foods that contribute to food allergies in the western world and peanut is the most common. Currently, there are no medical treatments that can cure an individual of food allergy, so avoidance of the allergic food is the only option. In the United States, there are three immunodominant allergic proteins accountable for patient sensitization to peanut, Arachis hypogea 1, 2, and 3 (Ara h 1, Ara h 2, Ara h 3). Therefore, research into why peanuts are more allergic than other foods that have homologous proteins is critical and may be obtained by studying the structural and

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Leon, Ronald P. "Structural and functional analysis of MCM helicases in eukaryotic DNA replication /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biophysics & Genetics, Program in Molecular Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 90-98). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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Derivi, Alexandre Guimarães. "Correlações eletrostáticas e de tamanho em um modelo de cela para dispersões coloidais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/12664.

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Dispersões coloidais estão presentes em muitas aplicações industriais e biológicas, tais como indústria de alimentos, cosméticos, produtos farmacêuticos e nanoestruturas. Devido a efeitos entrópicos, macromoléculas, quando imersas em uma solução de partículas pequenas, tendem a se aglomerar. Para evitar este fenômeno, cargas são adicionadas à superfície do colóide. Conseqüentemente, para manter o sistema neutro, a solução contém uma série de pequenos contraíons que neutralizam a carga do colóide. A inclusão de cargas pode evitar a aglomeração dos colóides, mas incorpora ao problema uma série d

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Chen, Song. "Design, synthesis and characterization of A-D-A structural porphyrin small molecules for bulk heterojunction organic solar cell applications." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/477.

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Bulk heterojunction organic solar cells (BHJ OSCs) have been recognized as one of the most promising next generation green technology alternatives to inorganic solar cells because of the low-cost, lightweight, flexibility. Specifically, the use of small molecules instead of polymers as donors in BHJ OSC have been developed very fast recently because small molecules can be facilely synthesized and easily purified, and have a determined molecular structure without batch-to-batch variations. To date, those among the most efficient small molecules were constructed as acceptor-donor-acceptor (A-D-A

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Hall, Catherine Jane. "Comparisons of solution structures of free and IL-1β bound Fab suggests a model for B cell receptor signalling". Thesis, University of Leicester, 2010. http://hdl.handle.net/2381/28119.

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Therapeutic antibodies are an important and growing class of biotherapeutics with the potential to treat a range of major human diseases. Structural knowledge of the complexes formed between antibodies and target proteins would provide valuable information about the mode of action of the therapeutic and potentially reveal a structural mechanism underlying antigen induced B cell receptor signalling. Often the Fab fragment of the antibody is used in therapeutics, however, there are currently no NMR-based structures available for Fab or Fab/antigen complexes, presumably due to the difficulties of

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Chami, Mohamed. "La couche cristalline de surface de corynebacterium glutamicum : modele d'organisation et mode d'assemblage." Paris 11, 1997. http://www.theses.fr/1997PA112030.

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Dans ce travail, nous avons realise une etude detaillee de la couche cristalline de surface de corynebacterium glutamicum, une bacterie a gram positif d'interet industriel. Cette etude a revele une organisation complexe de la partie externe de l'enveloppe cellulaire : la couche s se presente sous forme d'un reseau de symetrie hexagonale forme par la proteine ps2. Cette couche est intimement liee a une couche sous-jacente de nature probablement lipidique. La proteine ps2 presente a son extremite c-terminale une sequence tres particuliere de 21 acides amines hydrophobes. Nous avons montre que ce

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Kovari, Daniel T. "Investigations of the spreading and closure mechanisms of phagocytosis in J774a.1 macrophages." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54882.

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Phagocytosis is the process by which cells engulf foreign bodies. It is the hallmark behavior of white blood cells, being the process through which those cells ingest and degrade pathogens and debris. To date a large amount of research has focused on documenting the existence and role of biochemical components involved with phagocytosis. Scores of signaling molecules have been implicated in the complex signal cascade which drives the process. These molecules are small (typically no larger than 5 nanometers) and operate in a crowded, chemically “noisy,” environment, yet they coordinate the cell

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Bauer, David. "Využití tensegritních struktur pro modelování mechanického chování hladkých svalových buněk." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229836.

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The master’s thesis deals with the computational modelling of the mechanical testing of isolated smooth muscle cells. The main aims are to create computational model of a cell, to simulate single-axis tensile test and to modify the model so that the model reflects real mechanical response. The model of the cell includes cytoplasm, nucleus, cell membrane and cytoskeleton which is modelled as a tensegrite structure. On this model the tensile test was simulated in case of the cell with cytoskeleton and the cell with distributed the cytoskeleton. Force-elongation curves, which were obtained from t

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Liu, Yanhe. "Human oocytes and embryos viewed by time-lapse videography, and the development of an embryo deselection model." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2016. https://ro.ecu.edu.au/theses/1787.

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Despite its wide application today, in vitro fertilization (IVF) treatment continues to have relatively low efficacy, largely due to inaccuracy in selecting the best quality embryo(s) from the cohort for transfer. Novel methodologies for improved selection are being developed, and time-lapse observation of human embryos is gaining increasing popularity due to the more detailed morphokinetic information obtained plus uninterrupted culture conditions. The morphokinetic information enables the use of quantitative timings in developmental milestones of embryos and qualitative measures of abnormal

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Chang, Samuel Fu-Min. "A development and evaluation of the new pastoral structure and lay person training model among the Taiwan cell group church." Online full text .pdf document, available to Fuller patrons only, 2002. http://www.tren.com.

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Schuster, Simon [Verfasser], and Stefan [Akademischer Betreuer] Zahler. "Models for angiogenesis on micro-structured surfaces : a novel view on endothelial cell biology / Simon Schuster. Betreuer: Stefan Zahler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/109312492X/34.

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Aquino, José Miguel Redondo de. "Methods for the prediction of effective properties of metal foams." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/22354.

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Mestrado em Engenharia Mecânica<br>Given their unique properties, there is an increasing interest in using metal foams. In order to expand the usage of these materials, there is a great need to accurately characterize their effective properties. However, there is a great difficulty in predicting the properties of these inhomogeneous materials due to their irregularities and micro defects. The scope of this work is precisely to find analytical models or numerical methods that can describe the behaviour of metallic foams in an elastic regime. To do this, numerical methods and analytical models

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LUCO, DAYANE P. "Padronização de técnicas de isolamento de células de Langerhans imaturas e desenvolvimento de um modelo tridimensional de pele humana para testes de sensibilidade in vitro." reponame:Repositório Institucional do IPEN, 2014. http://repositorio.ipen.br:8080/xmlui/handle/123456789/23179.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2014-12-19T17:52:28Z No. of bitstreams: 0<br>Made available in DSpace on 2014-12-19T17:52:28Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado em Tecnologia Nuclear)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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Surendran, Anudeep. "Stochastic and continuum descriptions of population dynamics with spatial structure." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/207574/1/Anudeep_Surendran_Thesis.pdf.

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Spatial structures are ubiquitous in populations of plants, animals and cells, typically occurring as clustering or segregation. These spatial structures influence how individuals interact and the overall population dynamics. Yet, these details are rarely accounted for in classical population dynamics models. Through Individual-based and continuum models, I show that spatial structures can dramatically alter population dynamics. The thesis specifically explores the role of spatial structure in biologically and ecologically relevant scenarios, such as the movement of cells in the presence of bi

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UREÑA, MARTÍN Carlos. "Study of Caveolae Mechanotransduction Under 3D Compressive Stresses : Comparative Analysis of 2 Models Mimicking Structural and Mechanical Tumor Characteristics." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS525.

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La mécanique et le stress compressif jouent un rôle important dans la progression tumorale. Récemment, plusieurs approches ont été développées pour tester le stress en compression dans des modèles 3D in vitro. Dans le présent travail, nous montrons d’abord la pertinence de la compression dans l’organisation des fibroblastes associés au cancer (CAF), en enveloppant les cellules cancéreuses lors d’une compression isotrope 3D dans des capsules d’alginate creux. Dans ce système, les CAF couvrent les cellules cancéreuses en présence de compression selon un processus impliquant vraisemblablement une

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Manifacier, Ian. "Understanding adherent cell mechanics and the influence of substrate rigidity." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4106/document.

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L’ingénierie tissulaire est une stratégie médicale qui repose sur la régénération de tissu par les cellules avec ou sans matériaux. Pour maîtriser cette synthèse, il faut comprendre la cellule comme une part intégrante du tissu. Hormis ses interactions biochimiques avec son support, la cellule interagit également mécaniquement avec son environnement. Elle s’accroche à ce dernier et évalue sa dureté pour adapter sa réponse biologique. Dans cette étude, j’ai développé des modèles numériques pour analyser l’influence de la rigidité du substrat sur le comportement mécanique de la cellule, sur sa s

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Planas, Iglesias Joan 1980. "On the study of 3D structure of proteins for developing new algorithms to complete the interactome and cell signalling networks." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/104152.

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Proteins are indispensable players in virtually all biological events. The functions of proteins are determined by their three dimensional (3D) structure and coordinated through intricate networks of protein-protein interactions (PPIs). Hence, a deep comprehension of such networks turns out to be crucial for understanding the cellular biology. Computational approaches have become critical tools for analysing PPI networks. In silico methods take advantage of the existing PPI knowledge to both predict new interactions and predict the function of proteins. Regarding the task of predicting PPIs, s

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PASQUALINI, FRANCESCO. "Bioengineering shape, structure and function in primary and stem cell derived cardiomyocytes: in vitro and in-silico models of exitations contraction coupling." Doctoral thesis, Università Politecnica delle Marche, 2012. http://hdl.handle.net/11566/242032.

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L'industria farmaceutica sta attraversando una giuntura sfavorevole: lo sviluppo di nuove sostanze è diventato un processo estremamente costoso (>500M$/sostanza che finalmente raggiunge la fase dei trial clinici) e caratterizzato da una efficienza molto bassa (solo ~5/5000 sostanze inizialmente sintetizzate raggiunge la fase finale) che difficilmente potrà essere sostenuto ancora a lungo. Il ritorno su questo enorme investimento, infatti, è minacciato dalla possibilità che effetti tossici diretti o indiretti - dovuti per esempio a non comuni genetiche dei pazienti - possano non essere id

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Madrid, Canales Ignacio. "Model of Cellular Growth under Stress : Emergence of Heterogeneity and Impact of the Environment." Electronic Thesis or Diss., Institut polytechnique de Paris, 2024. http://www.theses.fr/2024IPPAX008.

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Cette thèse porte sur l'analyse statistique et mathématique de la croissance cellulaire à l'échelle individuelle sous l'effet d'un stress. À partir de l'analyse des données recueillies par Sebastián Jaramillo et James Broughton sous la direction de Meriem El Karoui, nous avons construit différents modèles permettant une compréhension à différents niveaux de l'impact que la réponse hétérogène au stress génotoxique (réponse SOS) a sur la croissance d'une population de bactéries Escherichia coli. Pour modéliser la dynamique de ces populations on utilise des processus stochastiques à valeurs mesur

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Brouard, Vianney. "Cell dynamics of multitype populations in oncology and Invasion probability of cooperative parasites in structured host populations." Electronic Thesis or Diss., Lyon, École normale supérieure, 2024. http://www.theses.fr/2024ENSL0037.

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Cette thèse porte sur l'étude de deux modèles stochastiques liés à des problèmes médicaux. Le premier vise à comprendre le processus épidémique généré par des bactériophages coopératifs dans une population de bactéries résistantes aux antibiotiques. Pour cela, nous introduisons un modèle épidémiologique où les infections sont générées par la coopération de parasites dans une population d'hôtes structurée selon un modèle de configuration. Une transition de phase est observée pour la probabilité d'invasion dépendant du degré de connectivité des sommets et du nombre de parasites générés lors d'un

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