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Zeitschriftenartikel zum Thema "Sub-Inhibitory concentrations of antibiotics"

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Mojsoska, Biljana, Melanie Ghoul, Gabriel G. Perron, Håvard Jenssen, and Fatima AlZahra’a Alatraktchi. "Changes in toxin production of environmental Pseudomonas aeruginosa isolates exposed to sub-inhibitory concentrations of three common antibiotics." PLOS ONE 16, no. 3 (2021): e0248014. http://dx.doi.org/10.1371/journal.pone.0248014.

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Pseudomonas aeruginosa is an environmental pathogen that can cause severe infections in immunocompromised patients. P. aeruginosa infections are typically treated with multiple antibiotics including tobramycin, ciprofloxacin, and meropenem. However, antibiotics do not always entirely clear the bacteria from the infection site, where they may remain virulent. This is because the effective antibiotic concentration and diffusion in vitro may differ from the in vivo environment in patients. Therefore, it is important to understand the effect of non-lethal sub-inhibitory antibiotic concentrations o
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Jamal, W., B. I. Duerden, and V. O. Rotimi. "The influence of exposure to various concentrations of five antimicrobial agents on intracellular cytotoxin B production in <i>Clostridioides difficile</i>." African Journal of Clinical and Experimental Microbiology 24, no. 3 (2023): 266–73. http://dx.doi.org/10.4314/ajcem.v24i3.6.

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Background: Clostridioides difficile is an important cause of healthcare-associated diarrhea. Several anti- microbial agents are known to promote C. difficile infection (CDI). The impact of various concentrations of ampicillin (AMP), cefotaxime (CTX), clindamycin (CC), metronidazole (MTZ) and vancomycin (VAN) on intra-cellular cytotoxin B production was investigated in this study.&#x0D; Methodology: Six clinical strains of C. difficile were grown at minimum inhibitory concentration (MIC) and sub-MIC concentrations of these antibiotics. Inoculum standardization was performed by Miles and Misra
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Casciaro, Bruno, Floriana Cappiello, Walter Verrusio, Mauro Cacciafesta, and Maria Luisa Mangoni. "Antimicrobial Peptides and their Multiple Effects at Sub-Inhibitory Concentrations." Current Topics in Medicinal Chemistry 20, no. 14 (2020): 1264–73. http://dx.doi.org/10.2174/1568026620666200427090912.

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The frequent occurrence of multidrug-resistant strains to conventional antimicrobials has led to a clear decline in antibiotic therapies. Therefore, new molecules with different mechanisms of action are extremely necessary. Due to their unique properties, antimicrobial peptides (AMPs) represent a valid alternative to conventional antibiotics and many of them have been characterized for their activity and cytotoxicity. However, the effects that these peptides cause at concentrations below the minimum growth inhibitory concentration (MIC) have yet to be fully analyzed along with the underlying m
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Browne, Katrina, Rajesh Kuppusamy, William R. Walsh, et al. "Antimicrobial Peptidomimetics Prevent the Development of Resistance against Gentamicin and Ciprofloxacin in Staphylococcus and Pseudomonas Bacteria." International Journal of Molecular Sciences 24, no. 19 (2023): 14966. http://dx.doi.org/10.3390/ijms241914966.

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Bacteria readily acquire resistance to traditional antibiotics, resulting in pan-resistant strains with no available treatment. Antimicrobial resistance is a global challenge and without the development of effective antimicrobials, the foundation of modern medicine is at risk. Combination therapies such as antibiotic–antibiotic and antibiotic–adjuvant combinations are strategies used to combat antibiotic resistance. Current research focuses on antimicrobial peptidomimetics as adjuvant compounds, due to their promising activity against antibiotic-resistant bacteria. Here, for the first time we
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Nanduri, Bindu, Mark L. Lawrence, Divya Swetha Peddinti, and Shane C. Burgess. "Effects of Subminimum Inhibitory Concentrations of Antibiotics on thePasteurella multocidaProteome: A Systems Approach." Comparative and Functional Genomics 2008 (2008): 1–12. http://dx.doi.org/10.1155/2008/254836.

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To identify key regulators of subminimum inhibitory concentration (sub-MIC) antibiotic response in thePasteurella multocidaproteome, we applied systems approaches. Using 2D-LC-ESI-MS2, we achieved 53% proteome coverage. To study the differential protein expression in response to sub-MIC antibiotics in the context of protein interaction networks, we inferredP. multocidaPm70 protein interaction network from orthologous proteins. We then overlaid the differential protein expression data onto theP. multocidaprotein interaction network to study the bacterial response. We identified proteins that co
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Portela, Raquel, Filipe Valcovo, Pedro L. Almeida, Rita G. Sobral, and Catarina R. Leal. "Antibiotic Activity Screened by the Rheology of S. aureus Cultures." Fluids 5, no. 2 (2020): 76. http://dx.doi.org/10.3390/fluids5020076.

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Multidrug resistant bacteria are one of the most serious public health threats nowadays. How bacteria, as a population, react to the presence of antibiotics is of major importance to the outcome of the chosen treatment. In this study we addressed the impact of oxacillin, a β-lactam, the most clinically relevant class of antibiotics, in the viscosity profile of the methicillin resistant Staphylococcus aureus (MRSA) strain COL. In the first approach, the antibiotic was added, at concentrations under the minimum inhibitory concentration (sub-MIC), to the culture of S. aureus and steady-state shea
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Trancassini, M., M. I. Brenciaglia, M. C. Ghezzi, P. Cipriani, and F. Filadoro. "Modification ofPseudomonas aeruginosaVirulence Factors by Sub-Inhibitory Concentrations of Antibiotics." Journal of Chemotherapy 4, no. 2 (1992): 78–81. http://dx.doi.org/10.1080/1120009x.1992.11739144.

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Chee, Jessica. "Identifying genes associated with biofilm production in Pseudomonas aeruginosa." Meducator 1, no. 33 (2018): 19–22. http://dx.doi.org/10.15173/m.v1i33.1796.

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Pseudomonas aeruginosa is an opportunistic pathogen associated with a variety of life-threatening diseases. Infections caused by P. aeruginosa can be nearly untreatable because of its multidrug-resistance. One of the characteristics of P. aeruginosa that helps it survive in high drug concentrations is its ability to form biofilms–large communities of cells encompassed by extracellular polymeric substances that defend against many antibiotics. In fact, sub-minimum inhibitory concentrations of antibiotics stimulate biofilm production. This project aims to identify genes associated with biofilm i
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Chow, Louise K. M., Timothy M. Ghaly, and Michael R. Gillings. "A survey of sub-inhibitory concentrations of antibiotics in the environment." Journal of Environmental Sciences 99 (January 2021): 21–27. http://dx.doi.org/10.1016/j.jes.2020.05.030.

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György, Éva, Károly Arnold Unguran, and Éva Laslo. "Biocide Tolerance and Impact of Sanitizer Concentrations on the Antibiotic Resistance of Bacteria Originating from Cheese." Foods 12, no. 21 (2023): 3937. http://dx.doi.org/10.3390/foods12213937.

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In this study, we determined and identified the bacterial diversity of different types of artisanal and industrially produced cheese. The antibiotic (erythromycin, chloramphenicol, kanamycin, ampicillin, clindamycin, streptomycin, tetracycline, and gentamicin) and biocide (peracetic acid, sodium hypochlorite, and benzalkonium chloride) resistance of clinically relevant bacteria was determined as follows: Staphylococcus aureus, Macrococcus caseolyticus, Bacillus sp., Kocuria varians, Escherichia coli, Enterococcus faecalis, Citrobacter freundii, Citrobacter pasteurii, Klebsiella oxytoca, Klebsi
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Dissertationen zum Thema "Sub-Inhibitory concentrations of antibiotics"

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Subrt, Natalia. "Effects of sub-inhibitory concentrations of cell wall active antibiotics on virulence gene expression in Staphylococcus aureus." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/17417.

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Infections caused by Staphylococcus aureus are a major concern to public health due to multifactorial virulence of the bacteria and increasing resistance to antimicrobial therapy. The bacterial cell wall continues to be the primary target for antibiotics used to treat staphylococcal infections. I have used promoter-lux reporter constructs to study the effects of sub-inhibitory concentrations of cell wall active antibiotics on virulence gene expression in S. aureus. Constructs made for virulence genes encoding Spa, an adhesin, RNAIII, a regulatory RNA molecule, and LukE, a leukotoxin E, were in
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Masadeh, Majed. "Studies on the effects of sub-minimal inhibitory concentrations of antibiotics on the virulence factors of biofilm bacteria." Thesis, Abertay University, 2005. https://rke.abertay.ac.uk/en/studentTheses/ee318b1c-d3f5-4357-8165-2bf1caed633d.

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<i>Pseudomonas aeruginosa</i> is a notorious nosocomial opportunist. Planktonic forms of this pathogen have been traditionally studied for its pathogenicity. Such studies have shown that sub-minimal inhibitory concentrations (sub-MICs) of antibiotics are able to negatively modulate pathogenicity. However, more recent findings suggest a biofilm basis of infection. In this study, monospecies and binary biofilms of <i>Pseudomonas aeruginosa</i> ATCC 15692 (PAOl) and <i>Escherichia coli</i> ATCC 10000 were investigated for their pathogenic potential using resistance and virulence as key pathogenic
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Paul, Terry R. "Influence of iron deprivation and sub-inhibitory concentrations of antifungal antibiotics on surface antigens of candida albicans yeast cells." Thesis, Aston University, 1988. http://publications.aston.ac.uk/12520/.

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This study examined the effect of iron deprivation and sub-inhibitory concentrations of antifungal agents on yeast cell surface antigen recognition by antibodies from patients with Candida infections. Separation of cell wall surface proteins by sodium dodecyl-polyacrylamide gel electrophoresis (SDS-PAGE) and immunological detection by immunoblotting, revealed that antigenic profiles of yeasts were profoundly influenced by the growth environment. Cells grown under iron-depleted conditions expressed several iron-regulated proteins that were recognized by antibodies from patient sera. An attempt
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Maniveau, Morgane. "Dissémination et évolution des intégrons de résistance : impact du mode de vie bactérien et du stress antibiotique." Electronic Thesis or Diss., Limoges, 2024. http://www.theses.fr/2024LIMO0118.

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Les intégrons de résistance (IR) de classe 1 sont des éléments génétiques bactériens qui permettent l’acquisition et l’expression de gènes de résistance aux antibiotiques. Cette étude examine comment la présence d'un IR chromosomique et le mode de vie bactérien, planctonique ou biofilm, affectent l'évolution des populations bactériennes exposées à des concentrations sub-inhibitrices d'antibiotiques. Pour ce faire, deux IRs synthétiques contenant trois cassettes de gènes, exprimées à partir des variants faible (PcW) ou fort (PcS), ont été intégrés dans la souche de E. coli, R3A. Les souches R3A
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Fermér, Elin. "Selection for Antibiotic Resistance Below Minimal inhibitory concentration in Biofilm." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409806.

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Antibiotics are today one of the most important cornerstones in modern healthcare when it comes to treating bacterial infections. It is an asset human kind have been leaning on for the last century, but excessive and widespread misuse of antibiotics have left deep scars in the form of multi resistant pathogenic strains of bacteria that we soon will not be able to treat. A lot of research have been invested in understanding the mechanisms and spread of resistance within bacteria living in planktonic form, overlooking the fact that there are more lifestyles that causes problems. In this study, f
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Doroshenko, Natalya. "The biofilm matrix at sub-inhibitory concentrations of vancomycin." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/366538/.

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Staphylococcus epidermidis biofilm formation is a primary cause of medical device infections, which are persistent and difficult to eradicate because biofilms intrinsically exhibit a naturally high level of antibiotic resistance. Although biofilm antibiotic resistance or tolerance is a multifactorial process, some mechanisms such as limited diffusion, low metabolic activity and persister cells, contribute to the failure of antibiotics in the treatment of biofilm infections. Current, antibiotic treatment strategies may provide biofilm infections with intermittent exposure to sub-minimum inhibit
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Gullberg, Erik. "Selection of Resistance at very low Antibiotic Concentrations." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235225.

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The extensive medical and agricultural use and misuse of antibiotics during the last 70 years has caused an enrichment of resistant pathogenic bacteria that now severely threatens our capacity to efficiently treat bacterial infections. While is has been known for a long time that high concentrations of antibiotics can select for resistant mutants, less is known about the lower limit at which antibiotics can be selective and enrich for resistant bacteria. In this thesis we investigated the role of low concentrations of antibiotics and heavy metals in the enrichment and evolution of antibiotic r
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Abu-Elteen, Khalid Hussein. "Effect of sub-inhibitory concentrations of antifungal drugs on adherence of Candida species." Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/33210.

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The adherence of three Candida species to human buccal epithelial cells (BECs) following treatment of the yeast with sub-inhibitory concentrations of amphotericin B, nystatin, miconazole nitrate, 5-fluorocytosine, octenidine and pirtenidine was investigated in vitro. Pre-incubation of C. albicans (two strains), C. tropicalis or C.kefyr with these antifungal drugs inhibited their adherence to varying degrees (reduction between 17% and 78% of the control value). Pre-treatment of yeast for a short period (l hr) had less effect on adhesion than pre-treatment for a long period (24 hr). Furthermore,
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Younson, Justine Sarah. "The paradoxic effects of sub-inhibitory concentrations of ciprofloxacin on pathogenic determinants in coagulase-negative staphylococci." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286761.

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Kadurugamuwa, Jagath L. "Influence of sub-inhibitory concentrations of cephalosporins on surface properties of klebsiella pneumoniae important in infection." Thesis, Aston University, 1985. http://publications.aston.ac.uk/12489/.

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Bücher zum Thema "Sub-Inhibitory concentrations of antibiotics"

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Kadurugamuwa, Jagath L. Influence of sub-inhibitory concentrations of cephalosporins on surface properties of klebsiella pneumoniae important in infection. University of Aston. Department of Pharmaceutical Sciences, 1985.

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Domingue, Pierre Alain Gilbert. Influence of sub-inhibitory concentrations of penicillin G on surface properties of iron-deprived staphylococcus aureus NCTC 6571. Aston University. Department of Pharmaceutical Sciences, 1986.

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Abu-Elteen, Khalid Hussein Ahmad. Effect of sub-inhibitory concentrations of antifungal drugs on adherence of Candida species. 1991.

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Buchteile zum Thema "Sub-Inhibitory concentrations of antibiotics"

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Gillissen, G., and B. Melzer. "Influence of Subminimal Inhibitory Concentrations of Antibiotics on Antigen Expression and Metabolic Activity of Salmonella Species." In The Influence of Antibiotics on the Host-Parasite Relationship II. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70748-3_9.

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Domingue, P. A. G., E. Schwarzinger, and M. R. W. Brown. "Growth Rate, Iron Depletion, and a Sub-Minimal Inhibitory Concentration of Penicillin G Affect the Surface Hydrophobicity of Staphylococcus aureus." In The Influence of Antibiotics on the Host-Parasite Relationship III. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73653-7_7.

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Srivastava, Anmol, Vivek Kumar, and Vishnu Agarwal. "Antimicrobial Activity of Some Essential Oils Against Pseudomonas aeruginosa." In Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022). Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_4.

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AbstractThe emergence of multidrug resistance in bacteria due to overuse of antibiotics is becoming an important health concern in recent years, which requires development of novel alternatives to fight against these bacteria. Essential oils (EOs) are secondary metabolites that have different components and chemical compositions which may provide promising solution to the problem of rising number of drug resistant bacteria, as they can effectively kill bacteria. Here, in this study our aim is to determine the efficacy of lemongrass, rosemary, clary sage, geranium and tea tree essential oil against Pseudomonas aeruginosa, using agar well diffusion method. The minimum inhibitory concentration (MIC) of these EOs were also determined. The chemical composition of these essential oils were known by gas chromatography-mass spectrometry (GC-MS) analysis. It was revealed in this study that most of the essential oils show antimicrobial property against the test bacterium. The MIC of lemongrass is 0.25% (v/v), rosemary is 1% (v/v), clary sage is 2% (v/v), geranium is 0.5% (v/v) and for tea tree oil is 1% (v/v). We can infer from this data that lemongrass, rosemary, clary sage, geranium and tree oil can be utilized to treat infections caused by Pseudomonas aeruginosa, which is a gram-negative bacterium.
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Busetto, Gian Maria, Ramadan Saleh, Murat Gül, and Ashok Agarwal. "Therapy in Oligozoospermia (Varicocele, Cryptorchidism, Inflammation, and Seminal Tract Infections)." In Practical Clinical Andrology. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-11701-5_14.

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AbstractThe management of infertile men with varicocele is highly debated. Varicocele repair (VR) can be either surgical (varicolectomy) or through angiographic embolization. Surgical repair of varicocele includes open non-microsurgical techniques whether inguinal (Ivanissevich) or high retroperitoneal ligation (Palomo), open microsurgical techniques (inguinal or sub-inguinal) or laparoscopic. The accumulating evidence suggests that VR can improve conventional sperm parameters (sperm concentration, motility, and morphology), seminal oxidative stress, sperm DNA fragmentation, and serum testosterone concentrations.Treatment of cryptorchism is based on surgical correction. The surgical approach for palpable undescended testis is inguinal orchidopexy with eventual repair of concomitant hernia. Scrotal surgical approach is a viable alternative. For nonpalpable undescended testis, surgical approach can be open or laparoscopic, in one or two stages and possibly with spermatic vessel transection. In some cases, orchiectomy is required (testis abdominal localization, impossibility of mobilization or high neoplastic risk).Male accessory gland infections, including infection and/or inflammation of accessory glands (prostate, seminal vesicles, and Cowper’s glands), and male genital tract infections are characterized by the presence of an elevated number of leukocytes and/or pathogens in semen, together with inflammatory signs. Management is based on different antibiotic therapies.
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Gant, Vanya. "Pharmacology of Anti-infective Drugs in Critical Illness." In Oxford Textbook of Respiratory Critical Care. Oxford University PressOxford, 2023. http://dx.doi.org/10.1093/med/9780198766438.003.0040.

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Abstract Summary The disturbed physiology of critical illness considerably impacts blood and tissue concentrations of antimicrobials. In addition, the antimicrobials themselves vary enormously in chemical structure (and therefore charge, solubility, hydrophilicity, etc.), adding yet more complexity to effective and correct calculation of appropriate dose and interval timing. Examples here include on the one hand increased concentrations of hydrophilic beta-lactam antibiotics secondary to poor renal function and/or acute kidney injury, and on the other decreased antibiotic concentrations from increased volumes of distribution, decreased protein binding, and (sometimes artificially augmented by filtration or haemodialysis) renal clearance. Lipophilic antibiotics such as macrolides are less affected by physiological changes—although issues such as obesity influence dosing for optimal outcomes. Some antibiotics also have a narrow efficacy range and therapeutic index. Accordingly, aminoglycosides work best when used in high, once-daily dosing strategies with mandatory therapeutic drug monitoring. On the other hand, beta-lactam antimicrobials often have very short half-lives and are either bactericidal or entirely ineffective when only just below therapeutic concentrations. With such drugs, the most important pharmacodynamic parameter is therefore a ‘time above minimal inhibitory concentration’ optimized with shorter administration regimens, extended or even continuous infusions. None of these considerations should absolve treating physicians from deciding whether individual cases of infection are not better treated by removing the source of infection, as antibiotics alone cannot be expected to deal with large, undrained infected collections for instance.
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Correa, Gabriel Veloso, José Felipe Leite Ferreira Rosa, Stephanie Priscila de Sousa Cezário, et al. "TOXICOLOGICAL EVALUATION AND IN SILICO PHARMACOKINETICS OF CEFTIOFUR IN HUMAN AND ENVIRONMENTAL HEALTH." In Science and Connections: The Interdependence of Disciplines. Seven Editora, 2024. https://doi.org/10.56238/sevened2024.037-107.

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Ceftiofur is a broad-spectrum cephalosporin, effective against Gram-positive and Gram-negative pathogens. This antibiotic works by inhibiting the synthesis of the bacterial cell wall. Antibiotics, used in both human and veterinary medicine, are drugs of concern when found in the environment. This is due to the fact that, even at low concentrations, prolonged exposure to these residues can lead to the emergence of resistant bacteria, compromising human health and environmental balance. Direct or indirect contact, whether through the food chain, water resources or animal excreta, represent the main routes of contamination. In the present study, in silico methodologies were employed to predict the molecular properties of the antibiotic Ceftiofur. The in silico environmental toxicology study showed that Ceftiofur is not toxic to bees, but is toxic to fish and crustaceans, and its chemical structure does not degrade in the environment. ADME in silico analysis indicated that the antibiotic does not present a favorable prediction for oral bioavailability, due to violations of the Lipinski criteria and has a moderate intestinal absorption rate and absence of permeability across the blood-brain barrier. In addition, the in silico pharmacokinetic study revealed that Ceftiofur has no inhibitory capacity on any of the five hepatic isoenzymes of cytochrome P450 complex (CYP450). The human in silico toxicology study showed promising results, demonstrating that the antibiotic is non-toxic (non-mutagenic) in the AMES test, has no carcinogenic properties, and is classified in category IV for acute oral toxicity, indicating low toxicity.
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Das, Pranjal P., Simons Dhara, and Mihir K. Purkait. "The Anaerobic Ammonium Oxidation Process: Inhibition, Challenges and Opportunities." In Ammonia Oxidizing Bacteria. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781837671960-00056.

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The anaerobic ammonium oxidation (anammox) process has been recognized as an efficient nitrogen removal technology. Anammox processes are gaining attention owing to their advantages over the conventional biological nitrogen removal processes. Anammox bacteria are susceptible to various wastewater pollutants, which limits the extensive application of the anammox process worldwide. In general, low-concentration pollutants lead to the promotion of the anammox activity, while high-concentration pollutants show inhibitory effects. Moreover, mainstream anammox processes face a variety of challenges that limit their stable operation, such as difficulty in the out-selection of nitrite-oxidizing bacteria, high organic carbon to nitrogen (C/N) ratio, retention of anammox bacteria, and the influence of high concentrations of ammonia and nitrite compounds. Efficient strategies are necessary to manage high carbon to nitrogen ratios, improve performance in low-intensity wastewater, and retain anammox bacteria. This chapter systemically summarizes the recent advances in the inhibition, mechanism involved and recovery process of conventional and emerging pollutants in the anammox process, such as organics, metals, antibiotics and nanoparticles. The key elements in the operation, and maintenance of mainstream anammox processes in full-scale wastewater treatment plants have also been demonstrated. Moreover, for improving the process performance, the primary influencing factors affecting the anammox process have been identified and discussed in this chapter. Taken together, this chapter effectively illustrates the critical perspective on the challenges and opportunities associated with mainstream anammox processes, which will provide an in-depth understanding for researchers and engineers working in this field.
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Gălăţanu, Mona Luciana, Mariana Panţuroiu, Mariana Popescu, and Carmen Marinela Mihăilescu. "Plant Extracts With Antibiotic Effect." In Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-5129-8.ch004.

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This chapter tries to describe the most important plant extracts and their bioactive compounds which determine the antibiotic activity. Pharmacological assays performed for each plant extract are presented, including the minimum inhibitory concentration (MIC) as the most used experimental method to determine antimicrobial activity. Also, the effective associations between classic antibiotics and plant extracts with antibacterial are presented. The mechanisms of action are deeply explained to the extent that they are known and discovered by in vitro and in vivo studies. Plant-derived compounds have different mechanism of action as antibiotics. They can have other target sites than traditional antimicrobials and subsequently having different mechanisms of action against microbes. Ultimately, this chapter tries to be an invitation to use plant extract as an alternative to chemical, synthetic antibiotics, or used complementary, synergistic for better therapeutically results.
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Molina-Gallardo, Axel R., Yesica R. Cruz-Martínez, Julieta Orozco-Martínez, Israel Valencia Quiroz, and C. Tzasna Hernández-Delgado. "The Roles of Farnesol and Farnesene in Curtailing Antibiotic Resistance." In Biotechnology and Drug Development for Targeting Human Diseases. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815223163124090005.

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In the extensive domain of “biotechnology and drug development for targeting human diseases”, essential oils have long been revered for their therapeutic potential. Among these, farnesol and farnesene stand out due to their pharmacological attributes. As the challenge of antibiotic resistance intensifies, the scientific community is increasingly exploring the potential of these traditional remedies. Using the KirbyBauer agar diffusion method, a qualitative assessment was conducted on two grampositive and two gram-negative bacterial strains. The broth microdilution technique further determined the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and the sensitizing impacts of these compounds. Both farnesol and farnesene exhibited antibacterial efficacy against all evaluated strains. Their synergistic potential was highlighted when combined with clavulanic acid, cefuroxime, and cefepime. Among these combinations, farnesene paired with cefepime showed pronounced efficacy against Escherichia coli 82 MR, with an MIC of 0.47 μg/mL. In contrast, in the investigation of Staphylococcus aureus 23MR, it was observed that this particular strain exhibited an increased sensitivity when exposed to combinations containing farnesol. Notably, the Minimum Inhibitory Concentration (MIC) was determined to be 0.03 µg/mL in the presence of both antibiotic agents. To gain deeper molecular insights, docking experiments were performed with the βlactamases of E. coli and S. aureus, focusing on the most effective combinations. All tested compounds—cefuroxime, cefepime, farnesene, and farnesol—acted as noncompetitive inhibitors, suggesting their potential mechanisms of action.
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Middleton, Stephen J., and Raymond J. Playford. "Bacterial overgrowth of the small intestine." In Oxford Textbook of Medicine, edited by Jack Satsangi. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0299.

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Small intestinal bacterial overgrowth can be defined as the presence of excessive bacteria in the small intestine which can interfere with digestion and absorption. Predisposing causes include sustained hypochlorhydria induced by proton pump inhibitors, small intestinal dysmotility and stasis due to anatomical or motor abnormalities, and reduced antibacterial activity as seen in immunological deficiency and chronic pancreatitis. Presentation is predominantly from consequences of malabsorption, including gastrointestinal symptoms (e.g. diarrhoea or steatorrhoea) and features of specific nutrient malabsorption (e.g. osteoporosis, anaemia, neuropathy, and night blindness). Definitive diagnosis is difficult, requiring a properly collected and appropriately cultured aspirate from the proximal small intestine revealing a total concentration of a mixed growth of bacteria generally greater than 10<sup>5</sup> organisms/ml. Alternative investigations frequently used include glucose/lactulose breath tests or either the <sup>13</sup>C- or <sup>14</sup>C-xylose breath test, with elevated levels of <sup>13</sup>CO<sub>2</sub> or <sup>14</sup>CO<sub>2</sub> found in the breath. There may be low levels of cobalamin (metabolized by Gram-negative anaerobes), increased serum folate (synthesized by overgrowth flora), and increased urinary indicans (intraluminal product of bacterial tryptophan metabolism). Aside from treatment of any nutritional deficiencies, specific treatment is with an antimicrobial that is effective against both aerobic and anaerobic enteric bacteria (e.g. doxycycline, amoxicillin–clavulanic acid, rifaximin, or ciprofloxacin), which can be administered in rotation to reduce antibiotic resistance. Where possible and appropriate, correction of any underlying cause should also be performed.
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Konferenzberichte zum Thema "Sub-Inhibitory concentrations of antibiotics"

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Recktenwald, Matthias, Muskanjot Kaur, Mohammed M. Benmassaoud, et al. "Soluble Antimicrobial Peptide (AMP) Screening to Rationally Design AMP-Hydrogels that Selectively Prevent Biofilm Formation." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.192_2024.

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Staphylococcus aureus is an opportunistic pathogen that lives on surfaces and skin and can cause serious infections once inside the body. While antibiotics effectively kill bacteria, there are a growing number of infections with antibiotic-resistant strains. Antimicrobial peptides (AMPs) are part of the innate immune system and can eliminate pathogens including bacteria, fungi, and viruses, and are a promising alternative to antibiotics. Although studies have reported that AMP-functionalized hydrogels can prevent bacterial adhesion and biofilm formation, these materials generally consist of on
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M. HASAN, Alaa. "STUDYING THE ANTIMICROBIAL EFFECT OF PHENOLIC COMPOUNDS EXTRACTED FROM CAULIFLOWER BRASSICA OLERACEA VAR. BOTRYTIS AGAINST SOME SPECIES OF PATHOGENIC CANDIDA." In VIII.International ScientificCongressofPure,AppliedandTechnological Sciences. Rimar Academy, 2023. http://dx.doi.org/10.47832/minarcongress8-7.

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Increasing microbial and fungal resistance to antibiotics is one of the biggest challenges facing the scientific community, therefore, finding alternative treatments is one of the ideal options to overcome this problem. The cruciferous family is one of the richest plants worldwide because it contains an important secondary metabolite‏ .Phenolics compound which are known for their antimicrobial properties. The sScop of this work is to estimate the antimicrobial influence of phenolic compound against four Candida spp. (C. albicans, C. tropicales, C. kyfer and C. parasilopses). The activity of fi
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Popov, Sergey, Aleksey Kuzmin, Tamara Sabgayda, and Nataly Vedenina. "Minimum inhibitory concentrations (MIC) determination of TB drugs and broad-spectrum antibiotics inM.tuberculosiswith M/X/TDR." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa3331.

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A.GHAFIL, Jenan, Nihad Taha Mohammed JADDOA, and Marwa shakib ALRAWI. "ACALYPHA AUSTRALIS PLANT PROMISING TREATMENT AGAINST BACTERIA." In VI.International Scientific Congress of Pure,Applied and Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress6-31.

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The research aimedtoevaluate theantibacterial effect of ethanol extract of Acalypha australisagainst eightbacterialstrains (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Actinomyces, Proteus mirabilis and Streptococcus pneumonia) with concentrations ranged from 3.90 to 2000 µg/ml. The sensitivity of bacterial isolates to various antibiotics was tested by VITIK2 Densi-Check equipment. The xtricate was made by a soaked powder of Acalypha australis with 80%ethanol in the unit of soxhlet extractions and after that was aseptically sift
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Saeed MOHAMMED, Luma. "STUDY THE ANTIBACTERIAL ACTIVITY OF ALCOHOLIC EXTRACT OF ALLIUM SATIVUM ON PSEUDOMONAS AERUGINOSA AND COMPARE WITH SOME ANTIBIOTICS." In V. International Scientific Congress of Pure, Applied and Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress5-3.

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Twenty isolate of P.aerugiosa isolated from Baghdad hospitals identified morphologically and biochemical tests then vitek system.Disk diffusion method carried out to determined the sensitivity of bacterial isolates to different antibiotics like amoxicillin,ciprofloxacin, meropenem and cefotaxim by using Muller-Hinton agar, the results showed that 100% of isolates had resistance to amoxicillin,40% of resistance to cefotxim, 20% of resistance to ciprofloxacin and meropenem. Agar well method used to determined the minimal inhibitory concentrations for alcoholic extract of Allium sativum which pre
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BAQER, Batool Abd Al Ameer, and Maysoon Khaleefah ABBAS. "EFFECT OF CEPHALOSPORINS ON ( BIOFILM PRODUCTION AND PROTEASE ) ACTIVITIES BY SOME BACTERIA ISOLATED FROM OTITIS MEDIA." In III.International Scientific Congress of Pure,Appliedand Technological Sciences. Rimar Academy, 2021. http://dx.doi.org/10.47832/minarcongress3-1.

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30 samples (swab) were collected from patients suffering from Otitis media. Swabs were implanted on the culture media blood agar and MacConkey agar to isolate the bacteria and to diagnose them using microscopic, culture and biochemical tests and confirmed by the Vitck-2 system. Of the total, 18 isolates were selected which belong to 8 (26.6%) Staphylococcus aureus, 5 (16.6%) Klebsiella pneumonia, and 4 (13.3%) Escherichia coli. All isolates were investigated for sensitivity to (18) antibiotics, six of them from the cephalosporins group The results showed that all isolates were 100% resistance
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Rammadan ABDUL, Fatima, Ihsan Ali RAHEEEM, Alaa Laebi ABDULLAH, and Batool Abd Al Ameer BAQER. "DETECTION OF SOME VIRULENCE FACTORS AND ANTIBIOTICS RESISTANCE OF KLEBSIELLA PNEUMONIAE." In DETERMINATION OF THE ACTUAL INTENSITY BY CORRECTION OF THE EMISSION SPECTRUM LINES OF HEAVY METALS CONTAINED IN CRUDE OIL USING LASER INDUCED PLASMA –TECHNIQUE. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress4-9.

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Background: Infections of Klebsiella pneumoniae can include; diarrhea, septicemia, pneumonia, urinary tract infection and infections of soft tissues. Many factors are donated to K. pneumoniae pathogenicity particularly production of enzymes and formation of biofilm. Objective: find the relationship between the resistance of K. pneumoniae bacteria to antibiotics of quinolones and their ability to produce enzymes of beta lactamase. Materials and Methods: The Study included isolation and identification of (51) isolate of K. pneumoniae and (94) isolates of other bacteria from different clinical so
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Soares, Jennifer M., Vanderlei S. Bagnato, and Kate C. Blanco. "Synergistic enhancement effects of antibiotic combination with photodynamic inactivation." In Latin America Optics and Photonics Conference. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/laop.2022.w4a.29.

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Antimicrobial resistance is one of the most severe threats to global public health in this century. Photodynamic Inactivation (PDI) is an alternative to antibiotic therapy, a standard treatment for infections because the combination of a photosensitizer with light leads to the production of reactive oxygen species that promote eliminating undesirable cells without bacterial selection and with few side effects for the patient. This work investigates whether PDI can restore bacterial sensitivity to antibiotics. PDI protocols using curcumin and light at 450 nm are applied at regular intervals and
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Takagi, Rika, Junji Fukuda, Hiroaki Suzuki, Keiji Nagata, and Nobuhiko Nomura. "Electrochemical microdevice for the determination of the minimum inhibitory concentration of antibiotics." In 2012 IEEE Sensors. IEEE, 2012. http://dx.doi.org/10.1109/icsens.2012.6411101.

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Sarvarova, E. R., E. A. Cherepanova, and I. V. Maksimov. "Antifungal activity of lipopeptides from endophytic strains of the genus Bacillus sp. against the fungus Stagonospora nodorum (Berk.)." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.216.

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The direct antibiotic effect of lipopeptides from four endophytic strains on the germination of spores of the pathogenic fungus Stagonospora nodorum (Berk.) was found and the minimum inhibitory concentration (MIC) of these lipopeptides was determined.
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Berichte der Organisationen zum Thema "Sub-Inhibitory concentrations of antibiotics"

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ศรีอุบลมาศ, นงลักษณ์, อารี ลออปักษา та สารี วิรุฬหผล. ฤทธิ์ต้านจุลชีพของน้ำผึ้ง. จุฬาลงกรณ์มหาวิทยาลัย, 1991. https://doi.org/10.58837/chula.res.1991.7.

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น้ำผึ้งทดสอบ 10 ตัวอย่าง มีฤทธิ์ยับยั้งการเจริญเติบโตของ Trichophyton mentagrophytes, Microsporum gypseum, และ Epidermophyton flocccosum โดยมีค่าเฉลี่ยเส้นผ่าศูนย์กลางของโซนใสอยู่ในช่วง 19.58 ? 0.29, 17.00 ? 0.61 ถึง 29.62 ? 0.29 และ 20.40 ? 1.59 ถึง 46.36 ? 1.06 มิลิลิตร ตามลำดับ น้ำผึ้งจากต่างประเทศมีฤทธิ์ยับยั้งการเจริญต่ำสุด ในขณะที่น้ำผึ้งตัวอย่างจากจังหวัดชุมพรให้ค่าสูงสุดจากตัวอย่างน้ำผึ้งอื่นๆ อย่างมีนัยสำคัญทางสถิติ ตัวอย่างน้ำผึ้งทั้งหมดไม่มีผลยับยั้งการเจริญเติบโตของ Aspergillus niger และเชื้อยีสต์ 2 ชนิด Saccharomyces cerevisiae และ Candida albicans เมื่อเปรียบเทียบกับกลุ่มควบคุมซึ
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