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Thematische Bibliographien / Tail surface test / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Tail surface test“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 1. Februar 2022

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1

Gao, Zong Jun, Jia Guo Ren, Jia Liang Li, et al. "The Comprehensive Test for Geothermal Tail-Water Disposal." Advanced Materials Research 403-408 (November 2011): 4522–27. http://dx.doi.org/10.4028/www.scientific.net/amr.403-408.4522.

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Geothermal reservoirs and groundwater resources in layered porous media in large sedimentary basins have enormous exploitation potential because of their extensive distribution, great quantity, and feasible temperatures and drilling depths. The discharge of geothermal wastewater (i.e. tail-water) on the surface is a serious environmental issue because of its high salinity content, so the Bureau of Geology Exploration and Mineral Resources Exploitation in Shandong Province, China called for the study of the disposal technique of the geothermal tail-water. The disposal test process is as follows

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Nicassio, Francesco, and Gennaro Scarselli. "Simulation and Test of Discrete Mobile Surfaces for a RC-Aircraft." Aerospace 6, no. 11 (2019): 122. http://dx.doi.org/10.3390/aerospace6110122.

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Morphing structures suitable for unmanned aerial vehicles (UAVs) have been investigated for several years. This paper presents a novel lightweight, morphing concept based on the exploitation of the “lever effect” of a bistable composite plate that can be integrated in an UAV horizontal tail. Flight dynamics equations are solved in Simulink environment, thus being able to simulate and compare different flight conditions with conventional and bistable command surfaces. Subsequently, bistable plates are built by using composite materials, paying particular attention to dimensions, asymmetric stac

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Fratto, Melanie A., and Andrew K. Davis. "Do black-furred animals compensate for high solar absorption with smaller hairs? A test with a polymorphic squirrel species." Current Zoology 57, no. 6 (2011): 731–36. http://dx.doi.org/10.1093/czoolo/57.6.731.

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Abstract In polymorphic mammalian species that display multiple color forms, those with dark, or melanic pelage would be prone to overheating, especially if they live in warm climates, because their fur absorbs solar energy at a higher rate. However, experimental studies indicate that certain physical properties of fur of dark individuals appear to prevent, or minimize heat stress, although it is not clear what properties do so. Here, we tested the possibility that black-furred individuals simply have shorter or thinner hair fibers, which would create a lighter (in terms of weight) coat or one

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Warguła, Łukasz, Bartosz Wieczorek, and Mateusz Kukla. "The selection of the tail lift parameters." AUTOBUSY – Technika, Eksploatacja, Systemy Transportowe 20, no. 1-2 (2019): 364–67. http://dx.doi.org/10.24136/atest.2019.067.

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People moving on wheelchairs overcome the forces of resistance such as: air resistance, resistance of the ascent, inertia force and rolling resistance force. Under certain conditions of use of the wheelchair, the only resistance that must overcome the driving force during the movement is the rolling resistance force. This situation occurs during uniformly rectilinear movement, on a flat level surface at speeds of up to 20 km/h, because at this speed the air resistance is negligible. Rolling resistance is mainly influenced by the mass of the rolling object and the rolling resistance coefficient

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Khan, Abid Ali, Muhammad Arif Ashraf, Asim Shehzad, Abroon Jamal Qazi, and Imran Hayat. "Computational and experimental studies of horizontal tail flutter suppression." Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering 233, no. 1 (2017): 34–43. http://dx.doi.org/10.1177/0954410017725363.

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Flutter is an extremely violent instability that may result in catastrophic failure. Thus, flutter clearance test is one of the critical phases in qualification of an aircraft’s airworthiness. During design and development process of an aircraft, flutter problems were experienced on an aerodynamic surface (horizontal tail). In order to tackle the observed problem, a number of approaches to optimize the design for flutter speed were computationally and experimentally studied and evaluated. This paper presents and discusses the outcomes of these studies. A hybrid approach based on evaluations an

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Gao, Zhenxing, Debao Wang, and Zhiwei Xiang. "A Method for Estimating Aircraft Vertical Acceleration and Eddy Dissipation Rate in Turbulent Flight." Applied Sciences 10, no. 19 (2020): 6798. http://dx.doi.org/10.3390/app10196798.

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Atmospheric turbulence is a typical risk that threatens the flight safety of civil aviation aircraft. A method of estimating aircraft’s vertical acceleration in turbulence is proposed. Based on the combination of wing and horizontal tail, the continuous change of aerodynamic force in turbulent flight is obtained by unsteady vortex ring method. Vortex rings are assigned on the mean camber surface to further improve the computing accuracy. The incremental aerodynamic derivatives of lift and pitching moment are developed, which can describe the turbulence effects on aircraft. Furthermore, a new a

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Kern, Martin, Perry Bartelt, Betty Sovilla, and Othmar Buser. "Measured shear rates in large dry and wet snow avalanches." Journal of Glaciology 55, no. 190 (2009): 327–38. http://dx.doi.org/10.3189/002214309788608714.

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AbstractWe present estimates of internal shear rates of real-scale avalanches that are based on velocity measurements. Optical velocity sensors installed on the instrument pylon at the Swiss Vallée de la Sionne test site are used to measure flow velocities at different flow heights of three large dry and wet snow avalanches. Possible sources of error in the correlation analysis of the time-lagged reflectivity signals measured by optical sensors are identified for real-size avalanches. These include spurious velocities due to noise and elongated peaks. An appropriate choice of the correlation l

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Li, Gang, Kai Pang, Lan Chi, Chang Xiang Liu, Li Jiang, and Li Qun Mo. "Experimental Study on Performance of Phase Change Thermal Storage Kang." Applied Mechanics and Materials 525 (February 2014): 451–56. http://dx.doi.org/10.4028/www.scientific.net/amm.525.451.

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In this paper, the author build a new type of Kang with paraffin as its heating surface. Paraffin is a kind of phase change material ,which can stroage and release heat at a relatively constant temperature. It can make full use of the heat of the smoke in the Kang and extend the Kang heating period. We do comparison test of the the traditional Kang room and the phase change Kang room and related temperature was recorded. The tested result shows that the average temperature of the head, medium and tail of traditional Kang varies greatly,the maximum difference of the temperature is over 20°C. Wh

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Tang, Yong, Liang Liang, You Xia Pang, Zong Ming Zhu, and Yan Xu. "Research of Erosion, Cavitation and Their Interactive Wears of Fluid Machinery Three-Phase Flow." Applied Mechanics and Materials 212-213 (October 2012): 1261–66. http://dx.doi.org/10.4028/www.scientific.net/amm.212-213.1261.

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There are erosion and cavitation in the wear of flow passage components of fluid machinery at the same time. With simulating the working conditions of hydraulic turbine, this paper studies the flow field (pressure field and fluid concentration distribution) of vapor-liquid-solid three-phase on the surface of test rotary table when there are erosion, cavitation and interactive wear on the test rotary table under different environmental pressure with computational fluid dynamics i.e. CFD method, and erosion and cavitation interactive wear test is made on the rotary wear test-bed. The results sho

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Xiao, Kanyan, Jennifer Garner, Kathleen M. Buckley, et al. "p120-Catenin Regulates Clathrin-dependent Endocytosis of VE-Cadherin." Molecular Biology of the Cell 16, no. 11 (2005): 5141–51. http://dx.doi.org/10.1091/mbc.e05-05-0440.

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VE-cadherin is an adhesion molecule critical to vascular barrier function and angiogenesis. VE-cadherin expression levels are regulated by p120 catenin, which prevents lysosomal degradation of cadherins by unknown mechanisms. To test whether the VE-cadherin cytoplasmic domain mediates endocytosis, and to elucidate the nature of the endocytic machinery involved, the VE-cadherin tail was fused to the interleukin (IL)-2 receptor (IL-2R) extracellular domain. Internalization assays demonstrated that the VE-cadherin tail dramatically increased endocytosis of the IL-2R in a clathrin-dependent manner

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Jønholt, Lisa, Cathrine Juel Bundgaard, Martin Carlsen, and Dorte Bratbo Sørensen. "A Case Study on the Behavioural Effect of Positive Reinforcement Training in a Novel Task Participation Test in Göttingen Mini Pigs." Animals 11, no. 6 (2021): 1610. http://dx.doi.org/10.3390/ani11061610.

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In laboratory animal research, many procedures will be stressful for the animals, as they are forced to participate. Training animals to cooperate using clicker training (CT) or luring (LU) may reduce stress levels, and thereby increase animal welfare. In zoo animals, aquarium animals, and pets, CT is used to train animals to cooperate during medical procedures, whereas in experimental research, LU seem to be the preferred training method. This descriptive case study aims to present the behaviour of CT and LU pigs in a potentially fear-evoking behavioural test—the novel task participation test

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Troncoso, Renata J., Daniel E. Herzberg, Constanza S. Meneses, Heine Y. Müller, Marianne P. Werner, and Hedie Bustamante. "Mechanical/thermal sensitivity and superficial temperature in the stump of long-term tail-docked dairy cows." PeerJ 6 (July 18, 2018): e5213. http://dx.doi.org/10.7717/peerj.5213.

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BackgroundTail docking of dairy cows is a painful procedure that affects animal welfare level. The aims of this study were first to evaluate the response to mechanical and thermal stimulation, and second to determine the superficial temperature of the stump of tail-docked dairy cows.MethodsOne hundred and sixty-four dairy cows were enrolled. From these, 133 cows were assigned to the tail-docked (TD) group and 31 cows were selected as control animals. The following sensory assessments to evaluate pain in tail-docked cows were performed. Sensitivity of the tail region in both groups of animals w

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DAHLVIK, PETER, GUILLERMO BLUVOL, KARL-HEINZ KAGERER, MANFRED ARNOLD, and DAN VARNEY. "Influence of topcoat pigment particle size distribution on tail-edge pick resistance in sheet-fed offset printing." June 2012 11, no. 6 (2012): 51–58. http://dx.doi.org/10.32964/tj11.6.51.

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This paper describes ground calcium carbonate pigment particle size distribution and its influence on the tail-edge picking of pilot-coated paper as determined in full-scale sheet-fed offset printing. A tailor-made method was developed using a modified printing plate and high-tack inks to assess surface strength in terms of edge picking. In addition to the type, fineness, and particle size distribution of the ground calcium carbonate pigment, we also evaluated the solids content of the coating color, binder level, clay usage, and calendering. The printing test method provided differentiation r

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Ramsey, P. M., and T. F. Page. "Interaction between High Speed Nylon Fiber and Unlubricated Ceramic Textile Guides." Textile Research Journal 62, no. 12 (1992): 715–28. http://dx.doi.org/10.1177/004051759206201204.

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The friction and wear behavior of alumina and titania textile guides in contact with high speed, dry nylon filaments has been studied using a novel, on-line, friction measuring device. The titania guides were worn very quickly to produce smooth grooves, which resulted in a large increase in fiber-guide friction. The alumina guides showed no appreciable wear during the short 1 hour tests, but a large amount of polymer deposit was produced. The morphology of the deposit was determined by the alumina guide topography. The smoother guides were smeared with polymer over the contact region. This adh

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Liu, Xintao, Yifang Ban, and Songnian Li. "An Across-Country Comparison of the Hierarchical Spatial Structures of Cities." GEOMATICA 68, no. 3 (2014): 207–17. http://dx.doi.org/10.5623/cig2014-305.

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This paper investigates the hierarchical structures of 29 selected European countries from the perspective of blocks and natural cities and makes an across-country comparison among the countries. Blocks are minimum cycles consisting of road segments in the road network of a whole country; natural cities are defined as the aggregations of small blocks. We test the size distributions of blocks and natural cities at the country level and find that both exhibit heavy-tailed distributions. The power law distribution of city sizes indicates the presence of the scaling property. Therefore, the cities

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Edelstein, Jerry, and Stuart Bowyer. "EUV Observations of Pulsars." International Astronomical Union Colloquium 160 (1996): 291–95. http://dx.doi.org/10.1017/s0252921100041749.

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AbstractThree pulsars have been detected with the Lexan (100 Å )filter of the EUVE Deep Survey telescope: the middle-aged isolated pulsars, PSR B0656+14 and Geminga, plus the aged millisecond pulsar PSR J0437–4715. The EUV detections have been used both alone and in combination with observations in other bandpasses to limit the physical state of the objects and to test theories regarding neutron star cooling and re-heating mechanisms. For Geminga, the EUVE data suggests the presence of an optical cyclotron spectral feature superimposed on the Rayleigh-Jeans continuum tail from a hot pulsar sur

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Mahdi Sajedi, Sayyed, Parviz Ghadimi, Mohammad Sheikholeslami, and Mohammad A. Ghassemi. "Experimental and numerical analyses of wedge effects on the rooster tail and porpoising phenomenon of a high-speed planing craft in calm water." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 233, no. 13 (2019): 4637–52. http://dx.doi.org/10.1177/0954406219833722.

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This paper presents experimental and numerical investigation of stability and rooster tail of a mono-hull high-speed planing craft with a constant deadrise angle. Initially, a one-fifth scale model was tested in a towing tank, which showed porpoising phenomenon at 8 m/s (equal to the speed of sailing). Subsequently, two wedges of 5 and 10 mm heights, based on the boundary layer calculations, were mounted on the aft section of the planing hull. These wedges were shown to increase the lift at the aft section. These experiments were carried out at different speeds up to 10 m/s in calm water. The

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McLennan, Hanna J., Stefan Lüpold, Pete Smissen, Kevin C. Rowe, and William G. Breed. "Greater sperm complexity in the Australasian old endemic rodents (Tribe: Hydromyini) is associated with increased levels of inter-male sperm competition." Reproduction, Fertility and Development 29, no. 5 (2017): 921. http://dx.doi.org/10.1071/rd15425.

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Spermatozoa exhibit considerable interspecies morphological variation across mammals, especially among murid rodents. In Australasia, most murids in the tribe Hydromyini have a spermatozoon with a highly complex head exhibiting an apical hook, characteristic of most murids, and two projections that extend from its upper concave surface, the ventral processes. In the present study we performed a phylogenetically controlled comparison of sperm morphology across 45 species of hydromyine rodents to test the hypothesis that the length and angle of both the apical hook and ventral processes, as well

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Pasieka, Tracy Jo, Lucie Maresova, Kimiyasu Shiraki, and Charles Grose. "Regulation of Varicella-Zoster Virus-Induced Cell-to-Cell Fusion by the Endocytosis-Competent Glycoproteins gH and gE." Journal of Virology 78, no. 6 (2004): 2884–96. http://dx.doi.org/10.1128/jvi.78.6.2884-2896.2004.

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ABSTRACT The gH glycoprotein of varicella-zoster virus (VZV) is a major fusogen. The realigned short cytoplasmic tail of gH (18 amino acids) harbors a functional endocytosis motif (YNKI) that mediates internalization in both VZV-infected and transfected cells (T. J. Pasieka, L. Maresova, and C. Grose, J. Virol. 77: 4194-4202, 2003). During subsequent confocal microscopy studies of endocytosis-deficient gH mutants, we observed that cells transfected with the gH tail mutants exhibited marked fusion. Therefore, we postulated that VZV gH endocytosis served to regulate cell-to-cell fusion. Subseque

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Paschmann, G., S. Haaland, B. U. Ö. Sonnerup, et al. "Characteristics of the near-tail dawn magnetopause and boundary layer." Annales Geophysicae 23, no. 4 (2005): 1481–97. http://dx.doi.org/10.5194/angeo-23-1481-2005.

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Abstract. The paper discusses properties of the near-tail dawnside and boundary layer, as obtained from Cluster plasma and magnetic field measurements during a single skimming orbit on 4 and 5 July 2001 that included 24 well-defined crossings by all four spacecraft. As a result of variations of the interplanetary magnetic field, the magnetic shear across the local varied between ~0° and ~180°. Using an improved method, which takes into account acceleration and thickness variation, we have determined the orientation, speed, thickness and current for the 96 individual crossings. The orientations

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Muangphra, Ptumporn, and Ravi Gooneratne. "Comparative Genotoxicity of Cadmium and Lead in Earthworm Coelomocytes." Applied and Environmental Soil Science 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/218929.

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To determine genotoxicity to coelomocytes,Pheretima peguanaearthworms were exposed in filter paper studies to cadmium (Cd) and lead (Pb) for 48 h, at concentrations less than the LC10—Cd: 0.09, 0.19, 0.38, 0.75, and 1.50 μg cm−2; Pb: 1.65, 3.29, 6.58, 13.16, and 26.32 μg cm−2. For Cd at 0.75 μg cm−2, in the micronucleus test (detects chromosomal aberrations), significant increases () in micronuclei and binucleate cells were observed, and in the comet assay (detects DNA single-strand breaks), tail DNA% was significantly increased. Lead was less toxic with minimal effects on DNA, but the binucle

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Bell, Michael M., Wen-Chau Lee, Cory A. Wolff, and Huaqing Cai. "A Solo-Based Automated Quality Control Algorithm for Airborne Tail Doppler Radar Data." Journal of Applied Meteorology and Climatology 52, no. 11 (2013): 2509–28. http://dx.doi.org/10.1175/jamc-d-12-0283.1.

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AbstractAn automated quality control preprocessing algorithm for removing nonweather radar echoes in airborne Doppler radar data has been developed. This algorithm can significantly reduce the time and experience level required for interactive radar data editing prior to dual-Doppler wind synthesis or data assimilation. The algorithm uses the editing functions in the Solo software package developed by the National Center for Atmospheric Research to remove noise, Earth-surface, sidelobe, second-trip, and other artifacts. The characteristics of these nonweather radar returns, the algorithm to id

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Huang, Zhengfei, Zhifeng Wang, Chuanhua Li, Kaifeng Yin, Dan Hao, and Jing Lan. "Application of Plasma-Sprayed Zirconia Coating in Dental Implants: Study in Implants." Journal of Oral Implantology 44, no. 2 (2018): 102–9. http://dx.doi.org/10.1563/aaid-joi-d-17-00020.

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The aim was to investigate the osseointegration of a novel coating—plasma-sprayed nanostructured zirconia (NSZ)—for dental implants. Nanostructured zirconia coating on non-thread titanium implant was prepared by plasma spraying, and the implant surface morphology, surface roughness, and wettability were measured. In vivo, nanostructured zirconia-coated implants were inserted in rabbit tibia, and the animals were sacrificed at 2, 4, 8, and 12 weeks after implantation. The bond strength between implant and bone was measured with the removal torque (RTQ) test. Osseointegration was observed by sca

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Chajec, Wojciech. "Comparison of flutter calculation methods based on ground vibration test result." Aircraft Engineering and Aerospace Technology 91, no. 3 (2019): 466–76. http://dx.doi.org/10.1108/aeat-03-2018-0102.

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PurposeA low-cost but credible method of low-subsonic flutter analysis based on ground vibration test (GVT) results is presented. The purpose of this paper is a comparison of two methods of immediate flutter problem solution: JG2 – low cost software based on the strip theory in aerodynamics (STA) and V-g method of the flutter problem solution and ZAERO I commercial software with doublet lattice method (DLM) aerodynamic model and G method of the flutter problem solution. In both cases, the same sets of measured normal modes are used. Design/methodology/approachBefore flutter computation, resona

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Bartelt, Perry, and Othmar Buser. "Frictional relaxation in avalanches." Annals of Glaciology 51, no. 54 (2010): 98–104. http://dx.doi.org/10.3189/172756410791386607.

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AbstractWe use velocity profile measurements captured at the Vallée de la Sionne test site, Switzerland, to find experimental evidence for the value of extreme, Voellmy-type runout parameters for snow avalanche flow. We apply a constitutive relation that adjusts the internal shear stress as a function of the kinetic energy associated with random motion of the snow granules, R. We then show how the Voellmy dry-Coulomb and velocity-squared friction parameters change (relax) as a function of an increase in R. Since the avalanche head is characterized by high random energy levels, friction decreas

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Rezvani, A., M. Mayer, I. Qin, J. Brunner, and Bob Chylak. "Stitch Bond Process of Pd-Coated Cu Wire: Experimental and Numerical Studies of Process Parameters and Materials." International Symposium on Microelectronics 2013, no. 1 (2013): 000312–17. http://dx.doi.org/10.4071/isom-2013-tp42.

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Cost reduction is the main driver in the recent transition to Cu wire bonding from predominate Au wire bonding. Other cost reduction in packaging comes from new developments in substrates and lead frames, for example, Pre-Plated Frames (PPF) and uPPF for QFP and QFN reduce the plating and material cost. However, 2nd bonds (stitch bonds) can be more challenging on some of the new leadframe types due to the rough surface finish and thin plating thickness. Pd-coated Cu (PCC) wire has been recently introduced to improve the wire bonding process with bare Cu wire, mainly to improve reliability and

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Wu, Zeng, Xiao Jun Ning, and Ping Rui Zhao. "Analysis of Fretting Wear of Type II Fastener Elastic Bar." Applied Mechanics and Materials 178-181 (May 2012): 1469–73. http://dx.doi.org/10.4028/www.scientific.net/amm.178-181.1469.

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The main function of fastener was achieved by elastic bar. The traditional method for the study of fatigue stress, strain analysis, which was not reflected the true situation, because the elastic bar in the work with other members of the contact surface between the mutual movement of tiny was created, i.e. fretting. The shear stress（）, relative displacement（） and two of the product（） of elastic bar was calculated out by applying Coulomb friction model of nonlinear contact theory of simulation of elastic bar and the surrounding contact element. Theoretical analysis was shown that, if the fre

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Wang, Tong, Nathalie Courtois-Coutry, Gerhard Giebisch, and Michael J. Caplan. "A tyrosine-based signal regulates H-K-ATPase-mediated potassium reabsorption in the kidney." American Journal of Physiology-Renal Physiology 275, no. 5 (1998): F818—F826. http://dx.doi.org/10.1152/ajprenal.1998.275.5.f818.

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Isoforms of the H-K-ATPase participate in active K resorption in the renal collecting tubule. The cytoplasmic tail of the β-subunit of the gastric H-K-ATPase includes a 4 amino acid motif which is highly homologous to tyrosine-based endocytosis signals. We have generated transgenic mice expressing an H-K-ATPase β-subunit in which the tyrosine residue in this sequence has been mutated to alanine. Mice expressing the mutated protein manifest constitutive hypersecretion of gastric acid, demonstrating that the β-subunit tyrosine-based motif is required for the regulated endocytosis of the H-K pump

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Geng, Huimin, Jae-Woong Lee, Zhengshan Chen, et al. "IL2RA (CD25) Recruits Inhibitory Phosphatases to the Cell Membrane and Mediates Negative Feedback Control of STAT5 Signaling in Acute Lymphoblastic Leukemia." Blood 124, no. 21 (2014): 788. http://dx.doi.org/10.1182/blood.v124.21.788.788.

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Abstract Background and hypothesis: CD25 (IL2RA, interleukin 2 receptor α chain) is a transmembrane protein with a 13aa cytoplasmic tail. CD25 cooperates with β- and γ-chains in binding IL-2, but does not contribute to cytokine signaling. During normal B cell development, CD25 is specifically upregulated on the surface of IL7-dependent pre-B cells and is also expressed on the surface of a subset of human pre-B ALL cases. CD25-expressing ALL is typically associated with poor clinical outcome. For these reasons, we studied the functional significance of CD25 expression on human pre-B ALL cells.

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Krzysiak, Andrzej. "Wind Tunnel Tests of the Tu-154M Aircraft Aerodynamic Characteristics." Journal of KONES 26, no. 3 (2019): 113–20. http://dx.doi.org/10.2478/kones-2019-0064.

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Abstract Determination of possible manoeuvres to be performed by the aircraft requires knowledge of its aerodynamic characteristics including, in particular, characteristics of the aircraft at configuration with deflected control surfaces. In this article, the wind tunnel tests results of the model of passenger Tu-154M aircraft manufactured at the scale 1:40 are presented. The model was designed and manufactured by the Military University of Technology based on the Tu-154M aircraft geometry obtained by full-scale object scanning. The model mapped all aircraft control surfaces, along with the g

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Homan, S. M., A. M. Mercurio, and S. E. LaFlamme. "Endothelial cells assemble two distinct alpha6beta4-containing vimentin-associated structures: roles for ligand binding and the beta4 cytoplasmic tail." Journal of Cell Science 111, no. 18 (1998): 2717–28. http://dx.doi.org/10.1242/jcs.111.18.2717.

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The alpha6beta4 laminin binding integrin functions in the assembly of type I hemidesmosomes, which are specialized cell-matrix adhesion sites found in stratified epithelial cells. Although endothelial cells do not express all the components of type I hemidesmosomes, endothelial cells can express the alpha6beta4 integrin. Because endothelial cells lose expression of alpha6beta4 in culture, we expressed recombinant alpha6beta4 in the dermal microvascular endothelial cell line, HMEC-1, to test whether endothelial cells can assemble adhesion structures containing alpha6beta4. Using immunofluoresce

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Seng, Lee Yeh, and Berna Hascakir. "Role of Intermolecular Forces on Surfactant-Steam Performance into Heavy Oil Reservoirs." SPE Journal 26, no. 04 (2021): 2318–23. http://dx.doi.org/10.2118/201513-pa.

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Summary This study investigates the role of polar fractions of heavy oil in the surfactant-steamflooding process. Performance analyses of this process were done by examination of the dipole-dipole and ion-ion interactions between the polar head group of surfactants and the charged polar fraction of crude oil, namely, asphaltenes. Surfactants are designed to reduce the interfacial tension (IFT) between two immiscible fluids (such as oil and water) and effectively used for oil recovery. They reduce the IFT by aligning themselves at the interface of these two immiscible fluids; this way, their po

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Selokar, N. L., P. Sharma, D. Kumar, R. K. Sharma, and P. S. Yadav. "24 EFFECT OF DONOR CELL TYPE ON IN VITRO AND IN VIVO DEVELOPMENTAL COMPETENCE OF CLONED BUFFALO (BUBALUS BUBALIS) EMBRYOS." Reproduction, Fertility and Development 28, no. 2 (2016): 142. http://dx.doi.org/10.1071/rdv28n2ab24.

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Selection of the donor cell type for somatic cell NT is very important based on its capability to be reprogrammed by the oocyte cytoplasm. A very wide variety of donor cells of different origin have been used for somatic cell NT, having differences in the overall efficiency. The aim of this study was to compare the cloning efficiency of donor cells derived from the ventral side of origin of tail skin and seminal plasma of a buffalo bull (age: 3 years old). Somatic cells from skin and seminal plasma were isolated and cultured as described by Selokar et al. (2014 PLOS ONE 9(3), e90755). Cultured

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Boonen, Marielle, Roberta Rezende de Castro, Gaëlle Cuvelier, Isabelle Hamer, and Michel Jadot. "A dileucine signal situated in the C-terminal tail of the lysosomal membrane protein p40 is responsible for its targeting to lysosomes." Biochemical Journal 414, no. 3 (2008): 431–40. http://dx.doi.org/10.1042/bj20071626.

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Transport of newly synthesized lysosomal membrane proteins from the TGN (trans-Golgi network) to the lysosomes is due to the presence of specific signals in their cytoplasmic domains that are recognized by cytosolic adaptors. p40, a hypothetical transporter of 372 amino acids localized in the lysosomal membrane, contains four putative lysosomal sorting motifs in its sequence: three of the YXXϕ-type (Y6QLF, Y106VAL, Y333NGL) and one of the [D/E]XXXL[L/I]-type (EQERL360L361). To test the role of these motifs in the biosynthetic transport of p40, we replaced the most critical residues of these co

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Miller, P., J. Agrell, J. Olsson, and K. Sjörs. "Axisymmetric afterbody experiments for CFD validation." Aeronautical Journal 98, no. 974 (1994): 137–46. http://dx.doi.org/10.1017/s0001924000049988.

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Summary An experiment is described which was undertaken specifically to provide CFD validation data for the case of transonic flow over nozzle afterbodies. The tests were undertaken with the AGARD standard 10° and 15° axisymmetric boat-tail geometries. Onset Mach numbers in the range 0·80-0·99 and subsonic and under-expanded jet plumes were employed in the tests. Test conditions were selected which provided a range of afterbody flow features from largely attached to shock-induced separated flows. A uniquely detailed set of surface pressure and flowfield data are presented. The flow data were a

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Adjamskiy, Sergey, Rostislav Podolskyi, and Ganna Kononenko. "Investigation of plastic properties of AISI 316l steel by method of registration of macrolocalization fields." System technologies 4, no. 135 (2021): 3–11. http://dx.doi.org/10.34185/1562-9945-4-135-2021-01.

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Selective laser melting is one of the modern methods of manufacturing parts in the production of machine-building equipment, a special place is occupied by complex technological processes used in the manufacture of high-load units of pneumatic-hydraulic system from heat-resistant alloys. The research was carried out on samples made of powder material - stainless steel AISI 316L martensite class. Metallographic studies showed that the density of the sample is 99.83%, the structure of the samples is a martensitic structure of equilibrium constructed tracks. Tests to determine the mechanical prop

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Ijaware, V. A. "Comparative Analysis of Ellipsoidal Height and Shuttle Radar Topographic Mission Elevation." Journal of Applied Sciences and Environmental Management 24, no. 8 (2020): 1397–402. http://dx.doi.org/10.4314/jasem.v24i8.14.

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Ellipsoidal elevation represents a precise geospatial data type within the analysis and modelling of various hydrological and ecological phenomenon required in preserving the human environment. Likewise, Shuttle Radar Topographic Mission (SRTM) has created an unparalleled data set of global elevations that are freely available for modelling ubiquitous environmental applications. This research aims to carry out a comparative analysis of ellipsoidal heights and SRTM heights with the following objectives: downloading DEM’s (SRTM) data covering the study area, determining the spot heights within t

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Wang, Haofeng, Zhenxing Gao, Hongbin Gu, and Kai Qi. "Estimation of Aircraft-Dependent Bumpiness Severity in Turbulent Flight." Applied Sciences 11, no. 4 (2021): 1796. http://dx.doi.org/10.3390/app11041796.

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Atmospheric turbulence threatens flight safety of civil aviation aircraft by inducing aircraft bumpiness. A severity estimation method of aircraft bumpiness in turbulent flight is explored according to in-situ Eddy Dissipation Rate (EDR) indicator. With the turbulence intensity derived from EDR value, a time series of longitudinal and vertical turbulence was generated according to von Karman turbulence model. In order to obtain the vertical acceleration response of aircraft, the continuous change of aerodynamic force on the assembly of wing and horizontal tail was computed by Unsteady Vortex L

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Atcha, Fawzia A., Adeela Syed, Beibei Wu, et al. "A Unique DNA Binding Domain Converts T-Cell Factors into Strong Wnt Effectors." Molecular and Cellular Biology 27, no. 23 (2007): 8352–63. http://dx.doi.org/10.1128/mcb.02132-06.

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ABSTRACT Wnt regulation of gene expression requires binding of LEF/T-cell factor (LEF/TCF) transcription factors to Wnt response elements (WREs) and recruitment of the activator β-catenin. There are significant differences in the abilities of LEF/TCF family members to regulate Wnt target genes. For example, alternatively spliced isoforms of TCF-1 and TCF-4 with a C-terminal “E” tail are uniquely potent in their activation of LEF1 and CDX1. Here we report that the mechanism responsible for this unique activity is an auxiliary 30-amino-acid DNA interaction motif referred to here as the “cysteine

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Redivo Júnior, Nildo, Camila Dutra de Souza, Ellyn Amanda Fonseca Martins, et al. "Scrotal thermography to assess the seminal quality in Nelore and Girolando bulls." Semina: Ciências Agrárias 41, no. 1 (2020): 131. http://dx.doi.org/10.5433/1679-0359.2020v41n1p131.

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Bull selection by andrological examination aims to estimate the reproductive capacity of the male. Bulls of zebu origin adapt better to high temperatures than bulls of taurine origin, which may influence scrotum temperature and seminal quality due to the imbalance of testicular thermoregulation. The objective of this study was to investigate the relationship between bioclimatic variables, the temperature of body and scrotal areas, assessed with infrared thermography, and the quality of fresh and post-thawed semen in zebu Nelore bulls (Bos taurus indicus) and Girolando bulls (Bos taurus taurus

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Chen, Juan, Jocelyn Schroeder, Xiaofeng Luo, Robert R. Montgomery, and Qizhen Shi. "The Impact of GPIba on the Efficacy of Platelet-Targeted FVIII Gene Therapy in Hemophilia a with Pre-Existing Anti-FVIII Immunity." Blood 126, no. 23 (2015): 1067. http://dx.doi.org/10.1182/blood.v126.23.1067.1067.

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Abstract Platelets play fundamental roles in hemostasis through surface proteins, e.g. GPIb, and storage proteins, such as von Willebrand factor (VWF). Our previous studies have demonstrated that FVIII ectopically targeted to platelets under control of the platelet-specific aIIb promoter (2bF8) is therapeutic in hemophilia A mice even in the presence of anti-FVIII inhibitory antibodies (inhibitors). Our recent studies have shown that VWF is essential in platelet-targeted FVIII gene therapy of hemophilia A with inhibitors. Without VWF, the clinical efficacy of platelet-FVIII was aborted. In pri

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Markovitz, Rebecca C., John F. Healey, W. Hunter Baldwin, Ernest T. Parker, Shannon L. Meeks, and Pete Lollar. "Decreasing the Humoral Response to Factor VIII By Targeted Deletion of Factor VIII - Specific B Cells." Blood 124, no. 21 (2014): 238. http://dx.doi.org/10.1182/blood.v124.21.238.238.

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Abstract The development of neutralizing anti-factor VIII (fVIII) antibodies (inhibitors) remains the most significant complication in the treatment of hemophilia A patients. Treatment of inhibitor patients consists of management of bleeding episodes using bypassing agents or porcine fVIII. Inhibitors can be eradicated by immune tolerance induction (ITI) using thrice-weekly administration of large doses of fVIII. However, ITI fails in approximately 30% of patients. Additionally, the median time to tolerance in successful cases is ~18 months, making ITI expensive and inconvenient. In the curren

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Liu, Hao, Jinjiang Shi, Jiasen Li, and Chao Liu. "Investigation on the Influence Caused by Shield Tunneling: WSN Monitoring and Numerical Simulation." Advances in Civil Engineering 2021 (February 16, 2021): 1–11. http://dx.doi.org/10.1155/2021/6620706.

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Traditional monitoring techniques are faced with the problems of low acquisition frequency and easy to be affected by the construction environment during the shield tunneling, which cannot meet the actual needs of timeliness monitoring of surrounding environmental impact on shield tunnel construction. Based on this actual demand, a wireless sensor network (WSN) system was used to monitor the response of shield tunnel segments and surrounding buildings during the shield tunneling in this study. According to the result of the signal transmission test, an optimization scheme of microelectromechan

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Kasirer-Friede, Ana, Barry Moran, Jennifer Nagrampa-Orje та ін. "ADAP is required for normal αIIbβ3 activation by VWF/GP Ib-IX-V and other agonists". Blood 109, № 3 (2006): 1018–25. http://dx.doi.org/10.1182/blood-2006-05-022301.

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Abstract Interaction between von Willebrand factor (VWF) and platelet GP Ib-IX-V is required for hemostasis, in part because intracellular signals from VWF/GP Ib-IX-V activate the ligand-binding function of integrin αIIbβ3. Because they also induce tyrosine phosphorylation of the ADAP adapter, we investigated ADAP's role in GP Ib-IX-V signal transduction. Fibrinogen or ligand-mimetic POW-2 Fab binding to αIIbβ3 was stimulated by adhesion of ADAP+/+ murine platelets to dimeric VWF A1A2 but was significantly reduced in ADAP−/− platelets (P < .01). αIIbβ3 activation by ADP or a Par4 thrombin r

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Hungerford, J. E., M. T. Compton, M. L. Matter, B. G. Hoffstrom, and C. A. Otey. "Inhibition of pp125FAK in cultured fibroblasts results in apoptosis." Journal of Cell Biology 135, no. 5 (1996): 1383–90. http://dx.doi.org/10.1083/jcb.135.5.1383.

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The tyrosine kinase called pp125FAK is believed to play an important role in integrin-mediated signal transduction. pp125FAK is associated both functionally and spatially with integrins, which are the cell surface receptors for extracellular matrix components. Although the precise function of pp125FAK is not known, two possibilities have been proposed: pp125FAK may regulate the assembly of focal adhesions in spreading or migrating cells, or pp125FAK may participate in a signal transduction cascade to inform the nucleus that the cell is anchored. To test these models in living cells, a peptide

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Murányi, Marianna, Resat Cinar, Orsolya Kékesi, et al. "Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists." BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/501086.

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Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles. We have shown previously that a new analogue,cis-1S,2R-aminocyclohexanecarboxylic acid2-endomorphin-2 (ACHC-EM2), had elevated mu-receptor affinity, selectivity, and proteolytic stability over the parent compound. In the present work, we have studied its antinociceptive effects and receptor regulatory processes. ACHC-EM2 displayed a somewhat higher (60%) acute antinociceptive response

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Ahn, Hyun Sook, Rudy Fuentes, Vincent Hayes, et al. "A Human-Specific, Platelet-Targeted, Thrombin-Activatable Urokinase (PLT/uPA-T) Demonstrates Selective Thromboprophylactic Properties in Two in Vivo Models." Blood 124, no. 21 (2014): 579. http://dx.doi.org/10.1182/blood.v124.21.579.579.

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Abstract Two major clinical limitations to the use of thrombolytic agents are their short half-life and lack of targeting specificity. We aimed to circumvent these limitations by targeting a platelet-bound, thrombin-activatable, low molecular weight urokinase, termed PLT/uPA-T, to nascent thrombi by a combination of two strategies: (1) Attaching the drug through its N-terminal scFv portion to human αIIb/β3 on the surface of platelets with nM affinity. (2) Protecting the uPA from rapid activation/inactivation in the circulation while simultaneously requiring its activation by thrombin through a

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Walters, Robert W., Wouter van't Hof, Su Min P. Yi, et al. "Apical Localization of the Coxsackie-Adenovirus Receptor by Glycosyl-Phosphatidylinositol Modification Is Sufficient for Adenovirus-Mediated Gene Transfer through the Apical Surface of Human Airway Epithelia." Journal of Virology 75, no. 16 (2001): 7703–11. http://dx.doi.org/10.1128/jvi.75.16.7703-7711.2001.

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ABSTRACT In well-differentiated human airway epithelia, the coxsackie B and adenovirus type 2 and 5 receptor (CAR) resides primarily on the basolateral membrane. This location may explain the observation that gene transfer is inefficient when adenovirus vectors are applied to the apical surface. To further test this hypothesis and to investigate requirements and barriers to apical gene transfer to differentiated human airway epithelia, we expressed CAR in which the transmembrane and cytoplasmic tail were replaced by a glycosyl-phosphatidylinositol (GPI) anchor (GPI-CAR). As controls, we expres

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Armstrong, R. Todd, Anna S. Kushnir, and Judith M. White. "The Transmembrane Domain of Influenza Hemagglutinin Exhibits a Stringent Length Requirement to Support the Hemifusion to Fusion Transition." Journal of Cell Biology 151, no. 2 (2000): 425–38. http://dx.doi.org/10.1083/jcb.151.2.425.

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Glycosylphosphatidylinositol-anchored influenza hemagglutinin (GPI-HA) mediates hemifusion, whereas chimeras with foreign transmembrane (TM) domains mediate full fusion. A possible explanation for these observations is that the TM domain must be a critical length in order for HA to promote full fusion. To test this hypothesis, we analyzed biochemical properties and fusion phenotypes of HA with alterations in its 27–amino acid TM domain. Our mutants included sequential 2–amino acid (Δ2–Δ14) and an 11–amino acid deletion from the COOH-terminal end, deletions of 6 or 8 amino acids from the NH2-te

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Wu, Eugene, Lars Pache, Dan J. Von Seggern, et al. "Flexibility of the Adenovirus Fiber Is Required for Efficient Receptor Interaction." Journal of Virology 77, no. 13 (2003): 7225–35. http://dx.doi.org/10.1128/jvi.77.13.7225-7235.2003.

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ABSTRACT The adenovirus (Ad) fiber protein mediates Ad binding to the coxsackievirus and Ad receptor (CAR) and is thus a major determinant of viral tropism. The fiber contains three domains: an N-terminal tail that anchors the fiber to the viral capsid, a central shaft region of variable length and flexibility, and a C-terminal knob domain that binds to cell receptors. Ad type 37 (Ad37), a subgroup D virus associated with severe ocular infections, is unable to use CAR efficiently to infect host cells, despite containing a CAR binding site in its fiber knob. We hypothesized that the relatively

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