Einloggen

Thematische Bibliographien / Toxicity testing In vitro / Dissertationen

Um die anderen Arten von Veröffentlichungen zu diesem Thema anzuzeigen, folgen Sie diesem Link: Toxicity testing In vitro.

Dissertationen zum Thema „Toxicity testing In vitro“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 30. Juli 2024

Geben Sie eine Quelle nach APA, MLA, Chicago, Harvard und anderen Zitierweisen an

Wählen Sie eine Art der Quelle aus:

Machen Sie sich mit Top-50 Dissertationen für die Forschung zum Thema "Toxicity testing In vitro" bekannt.

Neben jedem Werk im Literaturverzeichnis ist die Option "Zur Bibliographie hinzufügen" verfügbar. Nutzen Sie sie, wird Ihre bibliographische Angabe des gewählten Werkes nach der nötigen Zitierweise (APA, MLA, Harvard, Chicago, Vancouver usw.) automatisch gestaltet.

Sie können auch den vollen Text der wissenschaftlichen Publikation im PDF-Format herunterladen und eine Online-Annotation der Arbeit lesen, wenn die relevanten Parameter in den Metadaten verfügbar sind.

Sehen Sie die Dissertationen für verschiedene Spezialgebieten durch und erstellen Sie Ihre Bibliographie auf korrekte Weise.

1

Radburn-Smith, Marcus Alexander. "Novel in vitro models and methods for ocular toxicity testing." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443263.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

2

Yang, Jie. "Three dimensional perfused cell culture for in vitro toxicity testing." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:a72b7015-cc57-4bb8-904a-a5a88e2194f1.

Der volle Inhalt der Quelle

Annotation:

This study describes the development of a novel method of three dimensional perfused cell culture for in vitro toxicity testing. Multiple parallel perfused microbioreactors (TissueFlex<sup>TM</sup>) were adopted to provide a well-controlled cell culture environment. Alginate and collagen type I, commonly used as hydrogel scaffolds to support cell culture, were tested as the scaffolding materials for this application. Alginate supports cell proliferation, but does not support cell attachment. Collagen gel (type I), good for cell attachment but with poor mechanical strength, could be used at the

APA, Harvard, Vancouver, ISO und andere Zitierweisen

3

Lestari, Fatma Safety Science Faculty of Science UNSW. "Development of in vitro toxicity methods for fire combustion products." Awarded by:University of New South Wales. School of Safety Science, 2006. http://handle.unsw.edu.au/1959.4/24280.

Der volle Inhalt der Quelle

Annotation:

A large range of polymers are used in building and mass transport interiors which released more toxic products during combustion. This work explores the cytotoxicity of selected chemicals and smoke derived from materials combustion. A selection of polymers and fiberglass reinforced polymer (FRP) composites used in building and railway carriage interiors including: polyethylene (PE), polypropylene (PP), polycarbonate (PC), polymethyl methacrylate (PMMA), polyvinyl chloride (PVC), melamine plywood, and two FRPs were studied. A small scale laboratory fire test using a vertical tube furnace was de

APA, Harvard, Vancouver, ISO und andere Zitierweisen

4

Lawrence, J. N. "Cryopreservation and toxicity studies with cultured rat and human hepatocytes." Thesis, University of Surrey, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233123.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

5

Bruschi, Sam A. "Investigations into mechanisms of paracetamol-induced toxicity using ìn vitro' systems /." Title page, abstract and table of contents only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phb192.pdf.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

6

Yu, Lok Chiu. "Cellular metabolism in in vitro toxicity and toxicology studies." HKBU Institutional Repository, 2005. http://repository.hkbu.edu.hk/etd_ra/675.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

7

McKay, Gillian Claire. "Cryopreservation of hepatocyte monolayers : a potential in vitro model system for toxicity testing." Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366885.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

8

Bakand, Shahnaz Safety Science Faculty of Science UNSW. "Development of in vitro methods for toxicity assessment of workplace air contaminants." Awarded by:University of New South Wales. School of Safety Science, 2006. http://handle.unsw.edu.au/1959.4/24246.

Der volle Inhalt der Quelle

Annotation:

Exposure to air contaminants is significantly associated with both short-term and long-term health effects. However, the precise mechanisms that derive such effects are not always understood. While an extensive background database from in vivo toxicological studies have been developed, most toxicity data is from oral and dermal chemical exposures rather than inhalation exposure. There is a need to explore new alternative approaches to provide toxicity information particularly on this technically demanding area. This research explores the potential of in vitro methods for toxicity assessment of

APA, Harvard, Vancouver, ISO und andere Zitierweisen

9

Pu, Yubing. "Toxicity assessment of engineered nanoparticles." Thesis, Troyes, 2017. http://www.theses.fr/2017TROY0001/document.

Der volle Inhalt der Quelle

Annotation:

L'objectif de cette thèse est d'améliorer la compréhension de la toxicité de diverses nanoparticules de synthèse (ENPs) pour l'homme et l'écosystème. Les travaux réalisés s’appuient sur la combinaison de données toxicologiques et d’un modèle environnemental - le modèle USEtox. En tant qu'élément important de l'évaluation de l'impact du cycle de vie, le facteur de caractérisation (CF) a été utilisé, dans ce travail, comme indicateur de toxicité pour l'homme et l'écosystème. Pour avoir accès aux courbes dose-réponse et à différentes données toxicologiques, des expériences in vitro ont été réalis

APA, Harvard, Vancouver, ISO und andere Zitierweisen

10

Cadieux, Brigitte. "Development of a novel, rapid, in vitro assay for the detection of Clostridium botulinum neurotoxin type E." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32836.

Der volle Inhalt der Quelle

Annotation:

Botulism is a foodborne intoxication caused by ingestion of Clostridium botulinum neurotoxin (BoNT). Preliminary studies focussed on the production of polyclonal antisera against BoNT/E by immunizing a rabbit with botulinal toxoid type E. The antiserum was subsequently used to detect BoNT/E using the slot blot immunoassay where samples were applied to a slot blot filtration manifold and drawn by vacuum through a membrane. The membrane was then immunologically processed before chemiluminescent detection. However, the antisera lacked specificity and cross-reacted with closely related clostridia

APA, Harvard, Vancouver, ISO und andere Zitierweisen

11

Berkelind, Ellinor. "In vitro bioassays for toxicity testing of wastewater - an evaulation of different sample treatment techniques." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412525.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

12

Masango, Mxolisi Goodwill. "A comparative analysis of the cytotoxicity of cyanotoxins using in vitro (cell culture) and in vivo (mouse) assays." Diss., Pretoria : [s.n.], 2007. http://upetd.up.ac.za/thesis/available/etd-05122008-100402/.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

13

Nicholls-Grzemski, Felicity April. "The effect of short-term pretreatment with peroxisome proliferators on the acute toxicity of various toxicants, including paracetamol /." Title page, table of contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phn6158.pdf.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

14

Manglik, Aparna Safety Science Faculty of Science UNSW. "Development of comparitive methods for chemical analysis and in vitro cytotoxicity testing of contaminated sites." Awarded by:University of New South Wales. School of Safety Science, 2006. http://handle.unsw.edu.au/1959.4/25168.

Der volle Inhalt der Quelle

Annotation:

This project developed methodology for in vitro toxicity assessment of contaminated sites using the Promega?? MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy-methoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assay performed on human cells (HepG2 and Skin fibroblasts). The project included the development of a method for extracting contaminants from soil based on leaching and centrifugation. A number of solvents and surfactants were assessed for their suitability as extracting agents. The Zwitterionic surfactant CHAPS ({3[(3-Cholamidopropyl) dimethylammonio] propanesulphonic acid}), which is an i

APA, Harvard, Vancouver, ISO und andere Zitierweisen

15

Sega, Estela Munhoz. "Determinação da toxicidade in vitro e in vivo de novos organofosforados e ressonancia magnetica nuclear do cloreto de acetilcolina." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311381.

Der volle Inhalt der Quelle

Annotation:

Orientadores: Nelci Fenalti Hoerhr, Roberto Rittner Neto<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-06T21:30:04Z (GMT). No. of bitstreams: 1 Sega_EstelaMunhoz_M.pdf: 1403353 bytes, checksum: 0aec5b888298032d359cc1b3cf0905b6 (MD5) Previous issue date: 2006<br>Resumo: Esse estudo analisou as propriedades toxicológicas de novos compostos organofosforados. Foram realizados experimentos para avaliar a atividade anticolinesterásica desses organofosforados, in vitro, no sangue total através do método de Ellman

APA, Harvard, Vancouver, ISO und andere Zitierweisen

16

Haglund, Caroline. "Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications." Doctoral thesis, Uppsala universitet, Klinisk farmakologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150361.

Der volle Inhalt der Quelle

Annotation:

Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. A high correlation was seen when comparing the 50% inhibitory concentrations (IC50) from FMCA-GM with the IC50 from the established clonogenic assay (CFU-GM). In paper II, FMCA-GM was complemented with additional cell models, establishing a normal cell pa

APA, Harvard, Vancouver, ISO und andere Zitierweisen

17

Greenan, Rebecca. "Optimization of the VITROCELL® Exposure System for In Vitro Toxicity Testing of Diesel Emissions at the Air-Liquid Interface." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32254.

Der volle Inhalt der Quelle

Annotation:

Relative to traditional methods, air-liquid interface (ALI) exposures constitute a superior in vitro model for assessing the toxicological activity of complex aerosols. By removing the medium barrier, aerosols can be delivered to the cells at their apical surface. This project investigated the utility of the commercially available VITROCELL® exposure system for comparative toxicological assessment of complex aerosols (freshly-generated diluted diesel exhaust and simulated urban smog). The system setup was modified to improve control of aerosol properties (temperature and humidity) and cellular

APA, Harvard, Vancouver, ISO und andere Zitierweisen

18

Morrison, Roxanne. "The development of an in vitro system for the production of drug metabolites using microsomal enzymes from bovine liver." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1007698.

Der volle Inhalt der Quelle

Annotation:

Drug metabolism is a specialised subset of xenobiotic metabolism, pertaining to the breakdown and elimination of pharmaceutical drugs. The enzymes involved in these pathways are the cytochrome P450 family of isozymes. Metabolism is an important factor in determining the pharmacological effects of drugs. The main aim of this study was to develop a system whereby the major metabolites of drugs can be produced in vitro. An in vitro system was developed and optimised using commercially prepared microsomes from rat liver and coumarin (by monitoring its conversion to 7-hydroxycoumarin) as a model. T

APA, Harvard, Vancouver, ISO und andere Zitierweisen

19

Bellwon, Patricia [Verfasser], Wolfgang [Gutachter] Dekant, and Martin [Gutachter] Müller. "Kinetic assessment by in vitro approaches - A contribution to reduce animals in toxicity testing / Patricia Bellwon. Gutachter: Wolfgang Dekant ; Martin Müller." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1111784213/34.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

20

Reichel, Carmela Marie. "The effects of neonatal manganese exposure on impulsivity, unlearned motoric function, and reward." CSUSB ScholarWorks, 2005. https://scholarworks.lib.csusb.edu/etd-project/2788.

Der volle Inhalt der Quelle

Annotation:

This study examined the effects of low to moderate doses of manganese (0, 250, or 750 _g per day from PD 1-21) on a comprehensive battery of behaviors in rats during the neonatal period, preweanling period, and in adulthood.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

21

Wickramaratna, Janith C. "A pharmacological characterisation of death adder (Acanthophis Spp.) venoms and toxins." Monash University, Dept. of Pharmacology, 2003. http://arrow.monash.edu.au/hdl/1959.1/5514.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

22

Chapman, Laurie A. "Interactions of nutrients on methyl mercury toxicity in neuron X spinal chord hybrid cells (NSC-34) and human oligodendrocyte X rhabdomyosarcoma cells (MO3.13)." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36888.

Der volle Inhalt der Quelle

Annotation:

Exposure to methyl mercury (MeHg) is a global concern. Increased chronic exposure to MeHg among fish and marine mammal consuming populations will increase the risk of prenatal exposure and as a result, the risk of infant brain damage and neurotoxcity. It is therefore important to understand the role of environmental factors, such as nutrition, in determining susceptibility to MeHg toxicity. Three nutrients (selenium (Se), vitamin C and vitamin E) were selected for examination of their interactions with the mechanisms of McHg cytotoxicity in vitro. Two hybrid neural cell lines (M03.13 and NSC-3

APA, Harvard, Vancouver, ISO und andere Zitierweisen

23

Procópio, Andréa Lemos Falcão. "Efeito antimicrobiano residual e citotoxidade in vitro de resina acrílica para base de prótese após imersão prolongada em agentes de limpeza." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/25/25146/tde-26102015-103717/.

Der volle Inhalt der Quelle

Annotation:

O presente estudo in vitro objetivou avaliar a longo prazo o potencial antimicrobiano residual e a citotoxicidade de soluções químicas de limpeza de prótese quando incorporadas à resina acrílica termopolimerizável após sucessivos ciclos de imersão noturna diária. Discos (10mm x 1mm) de resina acrílica termopolimerizável para base de prótese (Lucitone 550) foram submetidos a três ciclos diários de desinfecção (8h/cada) em hipoclorito de sódio a 1% (NaClO), digluconato de clorexidina a 2% (CLX) ou água destilada (controle) durante 91 (T91) ou 183 dias (T183), simulando o período de 9 meses ou 1,

APA, Harvard, Vancouver, ISO und andere Zitierweisen

24

Widdowson, Alexandra. "Microbial toxicity testing of inorganic nanoparticles." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=227625.

Der volle Inhalt der Quelle

Annotation:

NPs are toxic to a wide range of organisms across trophic levels; gram-positive and gram-negative bacteria (Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus and Escherichia coli), algae (Pseudokirchneriella subcapitata), crustaceans (Daphnia magna and Thamnocephalus platyurus), fish (rainbow trout, zebrafish, trout) and plants (Lactuca sativa L. and Raphanus sativus L). Due to their lack of target specificity, NPs may pose an environmental risk. The antibacterial properties of Ag and Cu nanoparticles (NP) are enhanced by their large reactive surface area, compared to bulk count

APA, Harvard, Vancouver, ISO und andere Zitierweisen

25

Macdonald, Niall Patrick. "Microsystems manufacturing technologies for pharmaceutical toxicity testing." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/5070/.

Der volle Inhalt der Quelle

Annotation:

To meet the demands of political, ethical and scientific pressures on animal testing, research into possible alternatives is required. Data obtained with animal models often cannot be related to humans. Testing with current cell-based assays, microdosing and pharmacokinetic models contribute to reducing animal testing and improving the drug development process. Micro-fabrication and rapid prototyping techniques offer potential solutions to reduce the need for animal toxicity testing. The aim of this research was to develop biological platforms for in vitro toxicity testing to provide physiolog

APA, Harvard, Vancouver, ISO und andere Zitierweisen

26

Taylor, Nadine Suzanne. "Novel approaches to toxicity testing in Daphnia magna." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/668/.

Der volle Inhalt der Quelle

Annotation:

Current regulatory risk assessment strategies have several limitations, such as linking subcellular changes to higher-level biological effects, and an improved knowledge-based approach is needed. Ecotoxicogenomic techniques have been proposed as having the potential to overcome the current limitations, providing greater mechanistic information for ecotoxicological testing. In this thesis, metabolomics is explored as a novel method for toxicity testing using Daphnia magna. Initially I evaluated the potential application of Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

APA, Harvard, Vancouver, ISO und andere Zitierweisen

27

Derache, Philippe. "Influence de la reduction des xenobiotiques organo-nitres sur la peroxydation des phospholipides." Toulouse 3, 1986. http://www.theses.fr/1986TOU30062.

Der volle Inhalt der Quelle

Annotation:

Introduction aux problemes de la peroxydation radicalaire des lipides, notamment au travers de la toxicite de l'oxygene. Effets des composes organonitres sur cette toxicite (etudes in vivo, in vitro, etudes de la mutagenicite)

APA, Harvard, Vancouver, ISO und andere Zitierweisen

28

Holmes, Jan L. "Development of functional in vitro toxicity tests." Thesis, Aston University, 1998. http://publications.aston.ac.uk/10976/.

Der volle Inhalt der Quelle

Annotation:

In vitro toxicity tests which detect evidence of the formation of reactive metabolites have previously relied upon cell death as a toxicity end point. Therefore these tests determine cytotoxicity in terms of quantitative changes in specified cell functions. In the studies involving the CaCO-2 cell model, there was no significant change in the transport of [3H] l-proJine by the cell after co-incubation with either dapsone or cyclophosphamide (50!!M) and rat liver microsomal metabolite generating system. The pre incubation of the cells with N-ethylmalemide to inhibit Phase II sulphotransferase a

APA, Harvard, Vancouver, ISO und andere Zitierweisen

29

Payne, Chris 1971. "Phylogenetic trends in phytoplankton resistance to Cd and Cu toxicity." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=24033.

Der volle Inhalt der Quelle

Annotation:

Some species of marine phytoplankton are believed to be more tolerant of high concentrations of trace metals than others, but no conclusive test of this hypothesis has been conducted. Eleven species of phytoplankton representing 5 classes were grown in Aquil medium containing Cd$ sp{2+}$ concentrations between 10$ sp{-9.85}$ and 10$ sp{-6.84}$ M. Growth rates and intracellular concentrations of Cd, C, N and S were measured. Cadmium quotas (mol Cd/litre-cell volume) were lower in members of Bacillariophyceae than in Chlorophyceae, Prymnesiophyceae, Dinophyceae and Cyanophyceae (ANOVA, p $<$ 0.0

APA, Harvard, Vancouver, ISO und andere Zitierweisen

30

Adler, Sarah. "The use of pluripotent cells in developmental toxicity testing." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976069806.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

31

Kane, Amadou. "Intoxication subchronique par l'ochratoxine a, mycotoxine contaminant les aliments : effets nephrotoxiques et genotoxiques." Strasbourg 1, 1986. http://www.theses.fr/1986STR13126.

Der volle Inhalt der Quelle

Annotation:

Distribution tissulaire de l'ochratoxine marquee chez le rat et la souris (voie orale). Etude de la nephrotoxicite subchronique de doses faibles chez le rat en suivant dans l'urine et les tubules la variation des activites enzymatiques. Effet sur les enzymes de cellules renales mdck en culture. Etude de la genotoxicite de l'ochratoxine in vivo et in vitro

APA, Harvard, Vancouver, ISO und andere Zitierweisen

32

Naidoo, Vinasan. "Diclofenac in Gyps vultures a molecular mechanism of toxicity /." Electronic thesis, 2007. http://upetd.up.ac.za/thesis/available/etd-07032008-093716/.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

33

Mitchell, Roger Dale 1955. "Systemic indicators of inorganic arsenic toxicity in several species." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276678.

Der volle Inhalt der Quelle

Annotation:

Seven prospective biological indicators of systemic toxicity were examined at time points ranging from 15 minutes to 24 hours using male Sprague-Dawley rats, B6C3F1 mice, Golden-Syrian hamsters and Hartley guinea pigs following intraperitoneal dosing with 0.1 mg/kg and 1.0 mg/kg sodium arsenite. Rats and mice were also dosed with 1.0 mg/kg sodium arsenate. Pyruvate dehydrogenase (PDH) activity was significantly depressed at early time points in mice, hamsters and guinea pigs and at later time points in rats dosed with arsenic (III). Rats and mice dosed with arsenic (V) also exhibited PDH depre

APA, Harvard, Vancouver, ISO und andere Zitierweisen

34

Cikutovic, Salas Marcos A. "Pathologies in earthworms: sublethal biomarkers of xenobiotic toxicity." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798085/.

Der volle Inhalt der Quelle

Annotation:

This research is part of an overall program to develop and use a suite of acute and sublethal toxicity biomarkers, and testing protocols for use in assaying potential effects of complex mixtures of xenobiotics such as found in soils containing agricultural biocides and petrochemical wastes dredged sediments, and hazardous waste sites (HWS). The purpose of this study was to evaluate four biomarkers of sublethal pathology that could be used in an integrative model of multiple toxicity endpoints with the earthworm Lumbricus terrestris.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

35

Juchelka, Charlotte Milada. "Rapid toxicity assessment using ingestion rate as a sublethal biomarker." Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/25413.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

36

Johnson, Clint Edwin. "In vitro toxicity assessment of silver and zinc oxide nanoparticles." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0119.

Der volle Inhalt der Quelle

Annotation:

Nanotoxicology is a nascent field of study concerned with the potential for nanotechnology to adversely impact human health or result in ecological damage. Nanomaterials can display unique physicochemical properties not present in the parent bulk material and it is these properties that may be a potential source of toxicity. There are a growing number of examples of nanomaterials functioning differently in biosystems compared to the parent bulk material. With the rapid growth of nanotechnology and increasing exposure of people to novel nanomaterials there is an urgent need to evaluate the toxi

APA, Harvard, Vancouver, ISO und andere Zitierweisen

37

Keynes, Robert Geoffrey. "Nitric oxide reactivity and toxicity in brain tissue in vitro." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446781/.

Der volle Inhalt der Quelle

Annotation:

The role of nitric oxide (NO) in brain physiology and pathology is governed by its concentration, a function of the balance between synthesis and breakdown. Following cerebral ischaemia NO may play a protective or destructive role, and the literature is plagued by contradictory findings. Contributing to the confusion is a lack of knowledge as to what constitutes a toxic concentration of NO, how NO is inactivated in vivo, and a large number of potential pitfalls. Measured using an NO-sensitive electrode, most of the NO delivered using a NONOate donor was removed by reaction with tissue culture

APA, Harvard, Vancouver, ISO und andere Zitierweisen

38

Dhakal, Kiran. "Comparative in vitro estimates of inhalation toxicity of selected nanoparticles." Thesis, Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1639.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

39

Cookson, Mark R. "Studies of activation and toxicity in cultured astrocytes." Thesis, University of Salford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308094.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

40

Nielsch, A. S. "Effects of prostaglandins and prostaglandin synthetase inhibitors on liver toxicity." Thesis, University of Aberdeen, 1987. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU499301.

Der volle Inhalt der Quelle

Annotation:

A total of 22 non-steroidal anti-inflammatory drugs and derivatives were added to microsomes to study the denaturation of cytochrome P-450 to cytochrome P-420 in the absence of an NADPH-generating system. There was a highly significant correlation among the different compounds between the extent of denaturation of cytochrome P-450 and their surfactant potency. Endotoxin administration to rats caused a maximum decrease in hepatic microsomal enzymes after 24 hours. Significant decreases in cytochrome P-450 (40%), cytochrome b5 levels (22%), aminopyrine N-demethylase (31%) and biphenyl 4-hydroxyl

APA, Harvard, Vancouver, ISO und andere Zitierweisen

41

Burbank, Susan Elizabeth. "Development of rapid toxicity tests using enzyme inhibition as sulethal biomarker." Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/25401.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

42

Högberg, Helena. "Developmental Neurotoxicity Testing Using In vitro Approaches." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-30056.

Der volle Inhalt der Quelle

Annotation:

There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. Moreover, the development of the central nervous system (CNS) is a very complex process involving several different important event

APA, Harvard, Vancouver, ISO und andere Zitierweisen

43

Högberg, Helena. "Developmental Neurotoxicity Testing Using In vitro Approaches." Stockholm : The Wenner-Gren Institute, Stockholm University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-30056.

Der volle Inhalt der Quelle

Annotation:

Diss. (sammanfattning) Stockholm : Stockholms universitet, 2009.<br>The work of this thesis was performed at ECVAM, European Commission, Italy. At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: In press. Paper 3: In progress. Paper 4: In progress. Härtill 4 uppsatser.

APA, Harvard, Vancouver, ISO und andere Zitierweisen

44

Middendorf, Paul Joseph. "Development and evaluation of toxicity tests using Caenorhabditis elegans with reproduction, mutation, lethality, and behavior as end points." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/25201.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

45

Lai, Keng Po. "Study on the environmental contamination and mechanistic toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin." HKBU Institutional Repository, 2004. http://repository.hkbu.edu.hk/etd_ra/527.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

46

Mochan, Daria Galina. "Evaluation of a Rapid-screening Toxicity Test Using the Ciliate, Colpoda inflata (Stokes): Sensitivity and Bioavailability to Model Compounds." PDXScholar, 1996. https://pdxscholar.library.pdx.edu/open_access_etds/5165.

Der volle Inhalt der Quelle

Annotation:

Standard toxicity tests often require high costs for maintaining healthy cultures, so few test species are employed in routine ecotoxicological analysis. An alternative is the "battery of tests" approach involving using rapid toxicity tests for screening. Rapid-screening toxicity tests must display organism sensitivity, similarity in responses to other test organisms, relevancy to many circumstances, and repeatability. Protozoa are ideal candidates for rapid-screening bioassays. They are cosmopolitan, play important roles in ecosystems, and have high reproductive rates. Many protozoa can form

APA, Harvard, Vancouver, ISO und andere Zitierweisen

47

Hochart-Behra, Anne-Cécile. "Caractérisation, étude du pouvoir antioxydant et du potentiel thérapeutique d'extraits de bactéroïdes thetaiotaomicron." Thesis, Lille 2, 2011. http://www.theses.fr/2011LIL2S051.

Der volle Inhalt der Quelle

Annotation:

Notre équipe vient de découvrir une méthode originale d’obtention d’extraits de Bacteroides thetaiotaomicron (E) qui préserve sa viabilité. Après culture anaérobie de ce commensal intestinal en milieu gélosé pauvre en facteurs de croissance, puis exposition à l’air, la bactérie semble posséder et générer dans E tout l’équipement de détoxication des espèces réactives de l’oxygène in vitro. Il laisse alors augurer d’un pouvoir thérapeutique à visée anti-inflammatoire.Objectifs et méthodes : Le but est d’abord de caractériser E, aux plans glucidique, lipidique et protéique. Dans ce dernier cas, i

APA, Harvard, Vancouver, ISO und andere Zitierweisen

48

Bramble, Lisa Anne. "Utilization of mitochondrial and microsomal metabolism for the assessment of toxicity." Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-03122009-040409/.

Der volle Inhalt der Quelle

APA, Harvard, Vancouver, ISO und andere Zitierweisen

49

Davies, Joanna. "Synthesis of zwitterionic compounds for aquatic toxicity testing for QSAR correlation studies." Thesis, Swansea University, 2003. https://cronfa.swan.ac.uk/Record/cronfa42651.

Der volle Inhalt der Quelle

Annotation:

22 zwitterionic compounds (10 short-chain surfactants; 12 non-surfactants) were synthesised obeying the general formula R-N+(CH3)2(CH2)nSO3', where n = 2 to 4, by reacting the corresponding N, N-dimethylamines with either sodium-2-chloroethane sulfonate (n = 2), 1, 3- propanesulfonate (n = 3) or 1,4-butanesulfonate (n = 4). The R group varied from a C6 to C12 alkyl chain, to a phenylalkyl unit bearing a Cl to C4 chain and finally to a phenylpropyl unit with a C4 to C6 para-substituted alkyl group. Octanol/water partition coefficients of the 22 sulfobetaines were determined by a conventional st

APA, Harvard, Vancouver, ISO und andere Zitierweisen

50

Everitt, Victoria Jane. "The use of indigenous macroinvertebrates and Daphnia pulex in acute toxicity testing." Thesis, Rhodes University, 2000. http://hdl.handle.net/10962/d1005483.

Der volle Inhalt der Quelle

Annotation:

Aquatic toxicology has been identified as a valuable tool in the identification and management of chemical pollution in aquatic ecosystems. Standardised methodologies for acute aquatic bioassays have been adopted from international agencies. As a result of these standard methods, the use of laboratory cultured organisms for toxicity testing has been more popular than that of indigenous field-caught organisms. Included in these adopted methods are those for the cultured crustacean Daphnia pUlex. D.pulex is adapted to living in standing water and the suitability of this species to determine toxi

APA, Harvard, Vancouver, ISO und andere Zitierweisen

Wir bieten Rabatte auf alle Premium-Pläne für Autoren, deren Werke in thematische Literatursammlungen aufgenommen wurden. Kontaktieren Sie uns, um einen einzigartigen Promo-Code zu erhalten!