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Dissertationen zum Thema „Type-2 development“

Autor: Grafiati

Veröffentlicht am 24. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Smit, Nicolaas Andrias Johannes. "School-Initiated Type-2 Activities in Continuous Professional Teacher Development." Diss., University of Pretoria, 2002. http://hdl.handle.net/2263/78496.

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Professional development is more than marking an attendance register at a workshop. Professional development is a reflective process of continuous self-development that should inform the very essence of any learning context. This dissertation builds on how teachers experience school-initiated type-2 teacher professional development in secondary public schools and how their experiences may contribute to the work in the field of teacher professional development and assessment. Although a number of studies have examined teachers’ comprehension of the Continuous Professional Development framework

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Sitaraman, Sneha. "Alveolar type 2 epithelial cells in lung development and disease." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1571062200291287.

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3

Zoso, Alice. "Human tissue-on-a-chip development for Type 2 Diabetes studies." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423774.

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Type 2 Diabetes (T2D) results from an insulin resistance condition that affects mainly adipose and skeletal muscle tissues by altering their glucose uptake and leading to major clinical complications. Moreover, it is known that these tissues interact each other with a negative cross-talk that worsen the pathology. Due to its clinical complexity, T2D would require patient-specific treatment. In this context it will be extremely helpful to have in vitro human tissue-based assays, able to provide biological responses representative of the in vivo patient-specific pathology. The aim of this PhD t

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Khaled, Walid T. "The role of STAT6 and type-2 cytokines in mammary gland development." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612880.

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5

Rogers, Catherine. "Development of a glycemic index checklist for individuals with type 2 diabetes." Connect to resource, 2009. http://hdl.handle.net/1811/37245.

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6

Aljwaid, Husam O. Dakhil. "Relationships between iron, oxidative stress, glycated proteins and the development of atherosclerosis in Type 2 diabetes." Thesis, University of Plymouth, 2015. http://hdl.handle.net/10026.1/3222.

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Hyperglycaemia stimulates a variety of biochemical abnormalities. The area of particular interest in this study is the influence of non-enzymatic glycation of proteins on iron homeostasis, and particularly on non-transferrin-bound iron (NTBI) and its possible relation to atherogenesis in both Type 2 diabetic and obese non diabetic subjects. The link between non-enzymatic glycation of proteins and iron homeostasis, and development of macrovascular disease may be mechanistically different in Type 2 diabetic and obese non diabetic subjects due to a difference in the protein glycation pattern. Bec

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Zambon, Alessandro. "Development of microfluidic cell culture technology for the study of type 2 diabetes." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423422.

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Type 2 Diabetes Mellitus (T2DM) is a multi-factorial disease due to metabolic disorder with injuries in glucose homeostasis and body’s glucose uptake. The complexity of this disease led to the use of different classes of drugs acting with different mechanisms and targets and with effects that often change between patients. The number of people in the world with diagnosed T2DM is constantly increasing and consequently the cost for healthcare. Nowadays, a defined cure for T2DM patients has been not clearly identified. In the study of diabetes, animal models are one of the most popular syste

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Kikkas, Ingrid. "Development of immunoassays for diagnosis of type 1 diabetes." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114824.

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Le diabète de type 1 est une maladie auto-immune caractérisée par la destruction des cellules bêta des îlots de Langerhans du pancréas. Au cours de ce processus auto-immun, des auto-anticorps sont produits contre plusieurs antigènes des cellules bêta, par exemple l'insuline, l'acide glutamique décarboxylase (GAD65), la protéine tyrosine phosphatase (IA-2) et le transporteur de zinc (ZnT8). Au moins un auto-anticorps contre l'un de ces antigènes est présent dans> 95% des personnes atteintes de diabète de type 1 lors de la détection de l'hyperglycémie. Ces auto-anticorps peuvent servir de mar

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Chumachenko, Y., Вікторія Юріївна Гарбузова, Виктория Юрьевна Гарбузова, et al. "Association analysis between BGLAP rs1800247polymorphic variant and type 2 diabetes mellitus development among non-obese Ukrainians." Thesis, Sumy State University, 2020. https://essuir.sumdu.edu.ua/handle/123456789/77977.

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Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both genetic and environmental factors influence its development. Recent studies showed, that the bone tissue regulates systemic glucose metabolism through the secretion of undercarboxylated osteocalcin (uOCN) into the systemic circulation. It is known, that uOCN binds to the GPRC6A-receptor and, therefore, stimulates insulin expression and secretion in β-cells, as well as increases muscles, liver and adipose tissue sensitivity for insulin. Thus, the thymine to cytosine transition in OCN gene (BGLAP) pro

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Direk, Kenan. "The role of mitochondria in the development of insulin resistance and type 2 diabetes." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-mitochondria-in-the-development-of-insulin-resistance-and-type-2-diabetes(30f426ed-9221-473f-b177-acefda85acaa).html.

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This thesis explores three broad areas of interest in the pathophysiology of type 2 diabetes (T2D). The first part of the thesis examines the relative contributions of body fat measurements on T2D and related morbidities in a large cohort of twins. A proxy measure of visceral fat was constructed from anthropometric and dual-energy X-ray absorptiometry, its heritability was estimated at 58% using the classical twin model and its influence on morbidity was compared to total abdominal fat and the body mass index. The findings from this work show that intra-abdominal adiposity confers the greatest

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Yiannakas, Adonis. "The role of central IL-6 signalling in the development of Type 2 diabetes." Thesis, University of Dundee, 2016. https://discovery.dundee.ac.uk/en/studentTheses/fc156760-f5ac-4f02-8b8e-42cb58decd63.

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Diet induced obesity and Type 2 diabetes affect an alarming number of people in the world. Patients exhibit a number of associated co-morbidities that require treatment and reduce life expectancy. The development of Type 2 diabetes results from a chronic disruption of glucose homeostasis as a consequence of environmental and genetic factors. The regulation of hypothalamic metabolic signalling is understood to be critical to the dynamic and long-term maintenance of glucose homeostasis by virtue of its influence on peripheral effectors (pancreas, liver, muscle and fat). Prolonged periods of infl

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Fenaux, Martijn. "Molecular Pathogenesis and Development of a Genetically Engineered Vaccine for Type-2 Porcine Circovirus." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/27171.

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Porcine circovirus type 2 (PCV2) is the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), whereas the ubiquitous porcine circovirus type 1 (PCV1) is nonpathogenic for pigs. Since its initial detection in a Canadian commercial swine herd in 1991, PMWS has been detected in all swine producing regions of the world and is now a serious economic problem to the swine industry. The objectives of this dissertation were to biologically, genetically and experimentally characterize both PCV1 and PCV2, to identify the genetic determinant(s) for virulence and replication, and

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Al, Rawahi Abdul Hakeem Hamood. "Development of Cardiovascular Risk Assessment Model for People with Type 2 Diabetes in Oman." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/368188.

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Type 2 diabetes mellitus (DM) is one of the most common chronic diseases globally, with worldwide prevalence of 8.3%. Due to its long-lasting nature and high risk of complications, the burden of type 2 DM is expected to rise. Patients with type 2 DM have an estimated two-to-six fold higher risk of developing cardiovascular disease (CVD) compared to the general population. Moreover, CVD is considered the leading cause of morbidity and premature mortality in type 2 diabetic patients. CVD risk assessment tools in general are mathematical models or charts used to estimate the risk of a CVD event i

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Bowden, Davies K. A. "Physical inactivity and sedentary time : impact on metabolic health and development of type 2 diabetes." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3019572/.

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15

Pal, K. "Development of an online self-management intervention for adults with type 2 diabetes (HeLP-Diabetes)." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1559564/.

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Background: The prevalence of type 2 diabetes is increasing and estimates suggest that by 2030 nearly 1 in 10 adults worldwide will be living with this condition. 10% of the NHS budget is spent on treating diabetes and related complications like heart attacks, strokes and blindness. Improving self-management in people living with type 2 diabetes is crucial in reducing the morbidity and mortality associated with this disease. Uptake of group-based self-management training is low and there is an urgent need for evidence based and effective alternatives. Computer-based interventions have the pote

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Thurner, Matthias. "The role of novel genetic and epigenetic mechanisms in the development of Type 2 diabetes." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:7ae45a54-45ea-4cdc-9c65-0068adb9ce67.

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Type 2 diabetes (T2D) is a metabolic disease characterised by insulin resistance and beta-cell failure and a leading cause of mortality and morbidity. GWAS have identified pancreatic beta-cell dysfunction as a major player in T2D pathogenesis, but since the majority of signals reside in non- coding sequence the causal variant(s) and effector transcripts often remain undefined. Combining human genetic discoveries with genomic interrogation of relevant tissues was shown to provide a powerful strategy to understand the molecular disease mechanisms. Thus, the main aim of my DPhil project is to gen

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Malaiko, S. S. "Frequency of pulmonary edema development in patients with acute coronary syndrome and diabetes type 2." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19825.

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18

Nechytajlo, O. Yu. "Associations between the neuropathy and diabetic foot syndrome development in patients with type 2 diabetes." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17813.

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19

Lin, Chih-Wei. "Modeling glucose-insulin kinetics and development of type 2 diabetes in offspring of diabetic parents." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2741.

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Type 2 diabetes (T2D) has been studied for decades. Many risk factors of T2D have been identified, but few studies were designed to investigate the pharmacokinetics/ pharmacodynamics (PK/PD) risk factors preceding the onset of T2D. Moreover, although the disease progression of T2D has received considerable attention, little is known about the disease development of T2D. It is important to understand the temporal changes of the risk factors of glucose and insulin kinetics during the development of T2D for a better understanding of the etiology of T2D. The objectives of this work are: 1) to deve

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Чумаченко, Ярослав Дмитрович, Ярослав Дмитриевич Чумаченко, Yaroslav Dmytrovych Chumachenko, et al. "The Study of Association Between BGLAP HindIII-Polymorphic Variant And Type 2 Diabetes Mellitus Development Among Ukrainians With Arterial Hypertension." Thesis, Elsevier, 2021. https://essuir.sumdu.edu.ua/handle/123456789/83385.

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Background: Nowadays, the attention of scientists is focused on the systemic energy metabolism regulation by skeleton. Bone tissue affects the glucose turnover through the production of undercarboxylated osteocalcin (ucOCN), which in turn stimulates insulin expression and secretion as well as increases sensitivity of adipocytes, muscle cells and hepatocytes for this hormone. Current evidence showed an inverse association between serum OCN concentration and adverse metabolic outcomes, assuming the crucial role of OCN in type 2 diabetes mellitus (T2DM) pathogenesis. Objective: To analyze the l

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Shah, Urjita H. "A Roadmap for Development of Novel Antipsychotic Agents Based on a Risperidone Scaffold." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4804.

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Schizophrenia is a chronic psychotic illness affecting ~21 million people globally. Currently available antipsychotic agents act through a dopamine D2 receptor mechanism, and produce extrapyramidal or metabolic side effects. Hence, there is a need for novel targets and agents. The mGlu2/5-HT2A receptor heteromer has been implicated in the action of antipsychotic agents, and represents a novel and attractive therapeutic target for the treatment of schizophrenia. A long-term goal of this project is to synthesize bivalent ligands where a 5-HT2A receptor antagonist is tethered to an mGlu2 PAM via

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Hess, Melody L. "Development of a Nutrition Education Program Aimed at Diabetes Prevention and Management in an Urban Appalachian Population." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378109309.

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23

Tudor-Locke, Catrine Elizabeth. "Development, implementation and evaluation of a daily physical activity intervention for individuals with Type 2 diabetes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ51234.pdf.

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24

Lynch, Aisling Martina. "Development and characterisation of novel proglucagon-derived peptide analogues for the treatment of Type 2 diabetes." Thesis, Ulster University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674964.

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There is an acute medical need for additional drug therapies which offer improved efficacy and better glycaemic control for patients with Type 2 diabetes. Here the antidiabetic potential of several novel pro glucagon-derived peptide analogues were assessed in preclinical studies. Structural modifications, which include variations of glucagon and oxyntomodulin (Oxm), were used to develop novel peptide receptor agonists. Glucagon-based analogues assessed included native glucagon, (N-Acetyl)glucagon, (D-Ser2)glucagon, glucagon-Lys30-y-glutamyl-PAL and (D-Ser2)glucagon-end exendin. Overall, the gl

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Chen, Suxiang. "Development of novel chemically modified antisense oligonucleotides for tackling type 2 diabetes and Duchenne muscular dystrophy." Thesis, Chen, Suxiang (2020) Development of novel chemically modified antisense oligonucleotides for tackling type 2 diabetes and Duchenne muscular dystrophy. PhD thesis, Murdoch University, 2020. https://researchrepository.murdoch.edu.au/id/eprint/59137/.

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Therapeutic nucleic acids such as antisense oligonucleotides (AOs) can specifically bind to target RNA and manipulate gene expression through different mechanism of actions, including RNase H mediated RNA degradation, splice modulation, and translational repression. So far, the United States Food and Drug Administration has approved seven AO drugs for the therapies of different human diseases. Among them, four drugs (eteplirsen, golodirsen, nusinersen, milasen) modulate splicing, and rescue the production of functional essential proteins by restoring ruined open reading frames due to mutations

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Maksemous, Neven. "Development of high through-put neurogenetics diagnostics." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/101097/1/Neven_Maksemous_Thesis.pdf.

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This project was an effort to improve the speed and affordability of genetic testing for neurological disorders. The research involved the development of a genetic diagnostic testing technique using Next Generation Sequencing technologies to investigate Familial Hemiplegic Migraine and related neurological conditions. The method successfully expanded the scope of testing, resulting in the ability to detect genetic changes that would have gone unnoticed in previous tests and significantly reduced the cost of testing for patients and the healthcare system.

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Power, Ailsa M. "Community pharmacy type 2 diabetes care : design and evaluation of a model to support continuous professional development." Thesis, University of Strathclyde, 2008. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23484.

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To develop a competency based continuous professional development (CPD) support package based on a workbook of competencies for community pharmacists working with patients with diabetes mellitus type 2 in primary care. To monitor the competencies attempted and evaluate by means of a pre and post measurement of views and attitudes to CPD. Subjects and settings: (a) 19 health care team members in the model of care design, (b) 18 community pharmacists in consensus building, (c) 60 pharmacists in a controlled study to monitor and evaluate the package. Main outcome measures: (a) Model of Care, (b)

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Afemikhe, Juliana Ayafegbeh. "Development of a health education programme for self-management of Type 2 diabetes in Edo State, Nigeria." University of the Western Cape, 2016. http://hdl.handle.net/11394/4910.

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Philosophiae Doctor - PhD<br>Diabetes is a chronic, metabolic disease that requires lifelong medical management, health education and self-management. According to a World Health Organisation report, there is a global increase in the prevalence of diabetes and even more so in the low-and middle-income countries, specifically Nigeria, which has the highest number of people with diabetes in the African region of the World Health Organisation. As a global issue, the positive health outcomes of diabetes are tied to health education and self-management of the disease and using the health resources

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Cowan, Elaine. "Development of obestatin analogues and investigation of their effects on metabolism in obesity and type 2 diabetes." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706299.

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Obestatin is a 23 residue gastrointestinal peptide with alpha-helical structure, short half-life, and as yet, no identified receptor. Since discovery in 2005, it has been reported to have many beneficial metabolic and cardiovascular actions in normal physiology and experimental obesity/diabetes, a number of which have been confirmed and disputed. This thesis aimed to characterise the structure and activity of obestatin (1-23) and obestatin analogues in vitro, and to undertake in vivo studies to examine their metabolic actions and biochemical pathways. Initially, N-PEGylated obestatin (PEG-OB(1

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Su, Men. "Type 2 Diabetes Mellitus Acts as a Risk Factor for the Development of Early Stage Alzheimer’s Disease." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS121.

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Après le vieillissement, le diabète Mellitus de type 2 (DMT2) est le facteur de risque le plus important pour développer la maladie d'Alzheimer (MA). Le DMT2 est une maladie métabolique caractérisée par une hyperglycémie et une résistance à l’insuline qui se développe vers la cinquantaine et est fortement favorisée par l’obésité. Nous avons exploré l’impact potentiel du DMT2 sur le développement de la MA chez le Rat. Pour cela, nous avons utilisé un régime alimentaire cafétéria (RC) couplé à des injections de faibles doses de Streptozotocine (STZ) (STZ-CD). Les rats STZ-CD montrent des signes

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Dumas, Karine. "Implication de la protéine REDD1 dans les maladies métaboliques associées à l’obésité : REDD1 = Regulated in Development and DNA damage responses 1." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://www.theses.fr/2019AZUR4045.

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L’obésité est définie comme une accumulation excessive de graisse pouvant conduire à des problèmes de santé et sa prévalence mondiale ne cesse d’augmenter. L’obésité s’accompagne de désordres métaboliques comme la résistance à l’insuline, la stéatose hépatique et le diabète de type 2. REDD1 (Regulated in Development DNA damages responses 1) régule de nombreuses voies de signalisation impliquées dans la modulation de la balance énergétique cellulaire. Dans mon laboratoire d’accueil, nous avons montré que REDD1 est impliqué dans la voie de signalisation de l’insuline. L’objectif de ma thèse est

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Docherty, Paul David. "Evaluation and Development of the Dynamic Insulin Sensitivity and Secretion Test for Numerous Clinical Applications." Thesis, University of Canterbury. Department of Mechanical Engineering, 2011. http://hdl.handle.net/10092/5525.

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Given the high and increasing social, health and economic costs of type 2 diabetes, early diagnosis and prevention are critical. Insulin sensitivity and insulin secretion are important etiological factors of type 2 diabetes and are used to define an individual’s risk or progression to the disease state. The dynamic insulin sensitivity and secretion test (DISST) concurrently measures insulin sensitivity and insulin secretion. The protocol uses glucose and insulin boluses as stimulus, and the participant response is observed during a relatively short protocol via glucose, insulin and C-peptid

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Buckley, Patrick. "Development and Application of Microarray-Based Comparative Genomic Hybridization : Analysis of Neurofibromatosis Type-2, Schwannomatosis and Related Tumors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4786.

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Alemán, José O. (José Orlando). "Gluconeogenesis as a system : development of in vivo flux analysis of hepatic glucose production in Type 2 Diabetes." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43743.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2008.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Vita.<br>Includes bibliographical references (p. 289-300).<br>Metabolic diseases are an increasing health concern in the developed world. Type 2 Diabetes, (T2D) affects over 100 million people worldwide and significantly contributes to chronic diseases such as atherosclerosis and kidney failure. This condition is characterized by deregulation of glucose homeostasis

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Mutsago, Bernard. "Development and application of diabetes care (Type 2) indicators at primary level in the Cape Town metropole region." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/9365.

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Includes bibliographical references (leaves 68-75).<br>Since many of the diabetic complications can be prevented by good management, healthcare delivery ought to be of the highest quality possible. Therefore, continuous assessment and improvement of quality of care is important in order to give people with diabetes the care they deserve. This study aimed to develop a multi-faceted, indicator-based audit tool to evaluate the structural, process and outcome dimensions of quality of care for Type 2 diabetes at primary level in Cape Town metropole region.

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Provenzano, Lucy. "The role of cellular prion protein in the development of schwannomas and other Merlin-deficient tumours." Thesis, University of Plymouth, 2018. http://hdl.handle.net/10026.1/10784.

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Neurofibromatosis type 2 (NF2) is an inherited, multiple tumour disease caused by loss of the tumour suppressor protein, Merlin. There are several tumours associated with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is associated with upregulation of various growth factor receptors and their relevant signalling pathways. At present the only treatment options for NF2 are surgery or radiosurgery, both of which incur serious morbidity and are unable to prevent recurrence of tumours. Either new drug treatments, or re-p

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Ryan, Alexander. "The role of PtdIns(4,5)P2 and its regulatory proteins in the development of insulin resistance in cell culture models." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-ptdins45p2-and-its-regulatory-proteins-in-the-development-of-insulin-resistance-in-cell-culture-models(1d0f500c-7b21-46a3-9eee-ad53588344c9).html.

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Insulin resistance, a key risk factor for type 2 diabetes, can be defined as when cells fail to respond effectively to insulin. In striated muscle and fat, this manifests as impaired insulin-stimulated glucose uptake due to reduced plasma membrane insertion of the glucose transporter GLUT4. In cell culture models, insulin resistance induced by chronic exposure to insulin, endothelin-1 or glucosamine, is correlated with reduced immunoreactivity of the lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) in plasma membrane sheets. However, the reason for this decrease, and whether other f

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Rudenski, A. "Development of a model of insulin/glucose regulation to assist elucidation of the pathophysiology of type 2 diabetes mellitus." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382881.

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Parry, Helen. "The roles of genetics and glycaemic control in the development of LVH and Heart Failure in Type 2 Diabetes." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/b7000b88-606c-4675-afe7-b720e33d7952.

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Cardiovascular disease is the leading cause of morbidity and mortality in diabetes. Not everyone with diabetes develops either LVH or HF, proposed factors influencing this include glycaemic control and genetic factors. No studies to date have looked at the genetics of LVH and HF specifically in T2DM.This thesis investigates the importance of glycaemic control and genetic factors in HF and LVH in T2DM. Data from patients with T2DM in the Go-DARTS study were used to identify individuals with HF, non-HF controls, individuals with LVH and non-LVH controls. Weighted mean HbA1C was calculated for ea

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Wade, Louise S. "Development of Assessment and Screening Tool to Assist with Prevention and Identification of Charcot Foot in Type 2 Diabetics." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2770.

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Abstract Development of Assessment and Screening Tool to Assist with Prevention and Identification of Charcot Foot in Type 2 Diabetics by Louise Wade MSN, RN MS, West Texas A&M University, 2010 BS, West Texas A&M University, 2010 Project Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Nursing Practice Walden University August 2016 Abstract According to the World Health Organization, up to 50% of type 2 diabetic patients develop neuropathy, which may cause major infections, amputation, and Charcot foot due to impaired sensation. Early recognition and care is ess

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Grgano, Emanuele Marco [Verfasser], та Rolf W. [Akademischer Betreuer] Hartmann. "Development of 17β-hydroxysteroid dehydrogenase type 2 and type 1 inhibitors for the treatment of osteoporosis and estrogen dependent diseases / Emanuele Marco Grgano ; Betreuer: Rolf W. Hartmann". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1120985005/34.

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Hamrén, Bengt. "Safety and Efficacy Modelling in Anti-Diabetic Drug Development." Doctoral thesis, Uppsala University, Division of Pharmacokinetics and Drug Therapy, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8648.

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<p>A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population.</p><p>Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. The aim of this thesis was to develop mechanism-based PK-PD-disease models for important safety and efficacy biomarkers used in anti-diabetic drug development. </p><p>Population PK, PK-PD and disease models were developed, based on data from clinical studies in s

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Lødøen, Silje Drabløs. "Genetic Predisposition and Changes in Dietary Patterns may contribute to increased Development of Type 2 Diabetes in the Chinese Population." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-23291.

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Lifestyle diseases, such as type 2 diabetes (T2D) and cardiovascular diseases (CVDs), arerelated to overweight in the western world. Although lower occurrence of overweight hasbeen documented in China compared to western countries, an increase in such lifestylediseases has been observed during the last decades. The aim of this thesis was to study therelationship between lifestyle and the development of T2D and CVDs in the Chinesepopulation. The results may provide further knowledge concerning lifestyle diseases and maytherefore contribute to reduce disease development in the future. The experi

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Hadjiconstantinou, Michelle. "The development of an online emotional support programme to improve diabetes-related distress and well-being in type 2 diabetes." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42526.

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Background: Emotional support in type 2 diabetes (T2DM) is limited, however online-based programmes can be used as supplements for the emotional management of this condition. This research aimed to explore the emotional impact of T2DM and aimed to design a prototype of an evidence- and theory-based online programme to improve the emotional management of T2DM, especially well-being and diabetes-related distress. Methods: This thesis adopted a user-centered approach. A review of existing literature was undertaken to determine current concepts of well-being, diabetes-related distress (DRD) and st

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Марченко, Ірина Василівна, Ирина Васильевна Марченко, Iryna Vasylivna Marchenko, O. P. Onwughara та D. V. Hanin. "The impact of ЕNРР1 gene K121Q polymorphism on the development of concomitant cardiovascular diseases in patients with type 2 diabetes". Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/60774.

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Proven the important role of ENPP1 gene in the development of calcification of the vascular wall and insulin resistance. This contributes to cardiovascular disease (CVD) on the one hand, on the other – type 2 diabetes (T2DM).

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England, Clare. "Development of a brief evidence-based dietary assessment tool to promote healthy dietary change for people with Type 2 diabetes." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683701.

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Background Individualised dietary advice is essential for management of Type 2 diabetes (T2DM). In the DK dietary advice is often delivered by health professionals with limited nutrition training. It is not clear which dietary changes are most beneficial for adults with T2DM. Tools are needed to assist in providing individualised dietary advice. The aim of this thesis was to develop a brief dietary assessment tool, for use in the DK, for people with T2DM. Methods A questionnaire was developed. Item development was infonned by analysis of food diaries from people with T2DM who took part in a di

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Cassimatis, Mandy. "Development and evaluation of the Ontrack Diabetes Program : an automated, web-based type 2 diabetes self-management and dysphoria intervention." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/74485/1/Mandy_Cassimatis_Thesis.pdf.

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This research was conducted in the area of Clinical and Health Psychology. The study involved the development and evaluation of a novel, web-based program aimed to improve Type 2 diabetes self-management and mood. The program was developed as an original technological intervention aimed to improve access to support for rural and remote communities, and is currently being trialled across Australia with a larger sample size. The researcher aims to continue research into the field of clinical psychology, and in particular is interested in working on further interventions to support those with com

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Ghadzi, Siti Maisharah Sheikh. "Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317040.

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Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM. The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. The appropriate

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Connelly, Jennifer. "The development and feasibility testing of a virtual health trainer in the promotion of physical activity in people with Type 2 diabetes living in remote and/or rural areas." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230174.

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The purpose of this thesis was to aid in the development of a web-based physical activity intervention for people with type 2 diabetes living in remote and rural areas. Chapter 1 introduces the research area, the design of the thesis and the key research questions. The thesis is then made up of 5 key studies. Study one, a systematic review of the literature was conducted and reported in chapter 2. This review identified the technologies that have previously been used to promote physical activity in type 2 diabetes, it identified the methodological quality of each included technology and the ke

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New, Nelda F. "The development and outcomes of a co-created diabetes self-management education intervention : a pilot study /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Nursing) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 154-162). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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