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Thematische Bibliographien / VECTOR DE VIRUS / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „VECTOR DE VIRUS“

Autor: Grafiati

Veröffentlicht am 17. September 2021

Zuletzt aktualisiert am 30. Juli 2025

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1

Deyle, David R., Yi Li, Erik M. Olson, and David W. Russell. "Nonintegrating Foamy Virus Vectors." Journal of Virology 84, no. 18 (2010): 9341–49. http://dx.doi.org/10.1128/jvi.00394-10.

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ABSTRACT Foamy viruses (FVs), or spumaviruses, are integrating retroviruses that have been developed as vectors. Here we generated nonintegrating foamy virus (NIFV) vectors by introducing point mutations into the highly conserved DD35E catalytic core motif of the foamy virus integrase sequence. NIFV vectors produced high-titer stocks, transduced dividing cells, and did not integrate. Cells infected with NIFV vectors contained episomal vector genomes that consisted of linear, 1-long-terminal-repeat (1-LTR), and 2-LTR circular DNAs. These episomes expressed transgenes, were stable, and became pr

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Jangra, Sumit, Senthilraja Chinnaiah, Sneha Rashtrapal Patil, Bhavya Shukla, Ragunathan Devendran, and Manish Kumar. "Deciphering the Role of Virus Receptors in Plant–Virus–Vector Interactions." Receptors 3, no. 2 (2024): 255–79. http://dx.doi.org/10.3390/receptors3020013.

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Insect-transmitted plant viruses are a major threat to global agricultural crop production. Receptors play a prominent role in the interplay between host-pathogen and vector interaction. The virus–vector relationship involves both viral and vector receptors. Receptors-like kinases (RLKs) and receptor-like proteins play a crucial role in plant immunity, which acts as a basal defense. Pathogens can evade or block host recognition by their effector proteins to inhibit pathogen recognition receptor (PRR)-mediated signaling. Intriguingly, RLKs are also known to interact with viral proteins and impa

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Young, Won-Bin, Gary L. Lindberg, and Charles J. Link. "DNA Methylation of Helper Virus Increases Genetic Instability of Retroviral Vector Producer Cells." Journal of Virology 74, no. 7 (2000): 3177–87. http://dx.doi.org/10.1128/jvi.74.7.3177-3187.2000.

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ABSTRACT Retroviral vector producer cells (VPC) have been considered genetically stable. A clonal cell population exhibiting a uniform vector integration pattern is used for sustained vector production. Here, we observed that the vector copy number is increased and varied in a population of established LTKOSN.2 VPC. Among five subclones of LTKOSN.2 VPC, the vector copy number ranged from 1 to approximately 29 copies per cell. A vector superinfection experiment and Northern blot analysis demonstrated that suppression of helper virus gene expression decreased Env-receptor interference and allowe

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Wang, Xiao-Wei, and Stéphane Blanc. "Insect Transmission of Plant Single-Stranded DNA Viruses." Annual Review of Entomology 66, no. 1 (2021): 389–405. http://dx.doi.org/10.1146/annurev-ento-060920-094531.

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Of the approximately 1,200 plant virus species that have been described to date, nearly one-third are single-stranded DNA (ssDNA) viruses, and all are transmitted by insect vectors. However, most studies of vector transmission of plant viruses have focused on RNA viruses. All known plant ssDNA viruses belong to two economically important families, Geminiviridae and Nanoviridae, and in recent years, there have been increased efforts to understand whether they have evolved similar relationships with their respective insect vectors. This review describes the current understanding of ssDNA virus–v

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Bukovsky, Anatoly A., Jin-Ping Song, and Luigi Naldini. "Interaction of Human Immunodeficiency Virus-Derived Vectors with Wild-Type Virus in Transduced Cells." Journal of Virology 73, no. 8 (1999): 7087–92. http://dx.doi.org/10.1128/jvi.73.8.7087-7092.1999.

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ABSTRACT The interaction of human immunodeficiency virus (HIV)-derived vectors with wild-type virus was analyzed in transduced cells. Vector transcripts upregulated by infection had no measurable effect on HIV type 1 (HIV-1) expression but competed efficiently for encapsidation, inhibiting the infectivity and spread of HIV-1 in culture and leading to mobilization and recombination of the vector. These effects were abrogated with a self-inactivating vector.

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Cunniffe, Nik J., Nick P. Taylor, Frédéric M. Hamelin, and Michael J. Jeger. "Epidemiological and ecological consequences of virus manipulation of host and vector in plant virus transmission." PLOS Computational Biology 17, no. 12 (2021): e1009759. http://dx.doi.org/10.1371/journal.pcbi.1009759.

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Many plant viruses are transmitted by insect vectors. Transmission can be described as persistent or non-persistent depending on rates of acquisition, retention, and inoculation of virus. Much experimental evidence has accumulated indicating vectors can prefer to settle and/or feed on infected versus noninfected host plants. For persistent transmission, vector preference can also be conditional, depending on the vector’s own infection status. Since viruses can alter host plant quality as a resource for feeding, infection potentially also affects vector population dynamics. Here we use mathemat

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Catto, Michael A., Habibu Mugerwa, Brendon K. Myers, Sudeep Pandey, Bhabesh Dutta, and Rajagopalbabu Srinivasan. "A Review on Transcriptional Responses of Interactions between Insect Vectors and Plant Viruses." Cells 11, no. 4 (2022): 693. http://dx.doi.org/10.3390/cells11040693.

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This review provides a synopsis of transcriptional responses pertaining to interactions between plant viruses and the insect vectors that transmit them in diverse modes. In the process, it attempts to catalog differential gene expression pertinent to virus–vector interactions in vectors such as virus reception, virus cell entry, virus tissue tropism, virus multiplication, and vector immune responses. Whiteflies, leafhoppers, planthoppers, and thrips are the main insect groups reviewed, along with aphids and leaf beetles. Much of the focus on gene expression pertinent to vector–virus interactio

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Miyahira, Yasushi, Yasuhiro Takashima, Seiki Kobayashi, et al. "Immune Responses against a Single CD8+-T-Cell Epitope Induced by Virus Vector Vaccination Can Successfully Control Trypanosoma cruzi Infection." Infection and Immunity 73, no. 11 (2005): 7356–65. http://dx.doi.org/10.1128/iai.73.11.7356-7365.2005.

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ABSTRACT In order to develop CD8+-T-cell-mediated immunotherapy against intracellular infectious agents, vaccination using recombinant virus vectors has become a promising strategy. In this study, we generated recombinant adenoviral and vaccinia virus vectors expressing a single CD8+-T-cell epitope, ANYNFTLV, which is derived from a Trypanosoma cruzi antigen. Immunogenicity of these two recombinant virus vectors was confirmed by the detection of ANYNFTLV-specific CD8+ T cells in the spleens of immunized mice. Priming/boosting immunization using combinations of these two recombinant virus vecto

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Choi, Charles Q. "Vector without Virus." Scientific American 292, no. 3 (2005): 30. http://dx.doi.org/10.1038/scientificamerican0305-30c.

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Hofmann, Wolfgang, David Schubert, Jason LaBonte, et al. "Species-Specific, Postentry Barriers to Primate Immunodeficiency Virus Infection." Journal of Virology 73, no. 12 (1999): 10020–28. http://dx.doi.org/10.1128/jvi.73.12.10020-10028.1999.

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ABSTRACT By using replication-defective vectors derived from human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIVmac), and murine leukemia virus (MuLV), all of which were pseudotyped with the vesicular stomatitis virus (VSV) G glycoprotein, the efficiency of postentry, early infection events was examined in target cells of several mammalian species. Titers of HIV-1 vectors were significantly lower than those of SIVmacand MuLV vectors in most cell lines and primary cells from Old World monkeys. By contrast, most New World monkey cells exhibited much lower titers for t

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Tsai, Chi-Wei, Adib Rowhani, Deborah A. Golino, Kent M. Daane, and Rodrigo P. P. Almeida. "Mealybug Transmission of Grapevine Leafroll Viruses: An Analysis of Virus–Vector Specificity." Phytopathology® 100, no. 8 (2010): 830–34. http://dx.doi.org/10.1094/phyto-100-8-0830.

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To understand ecological factors mediating the spread of insect-borne plant pathogens, vector species for these pathogens need to be identified. Grapevine leafroll disease is caused by a complex of phylogenetically related closteroviruses, some of which are transmitted by insect vectors; however, the specificities of these complex virus–vector interactions are poorly understood thus far. Through biological assays and phylogenetic analyses, we studied the role of vector-pathogen specificity in the transmission of several grapevine leafroll-associated viruses (GLRaVs) by their mealybug vectors.

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Croyle, Maria A., Shellie M. Callahan, Alberto Auricchio, et al. "PEGylation of a Vesicular Stomatitis Virus G Pseudotyped Lentivirus Vector Prevents Inactivation in Serum." Journal of Virology 78, no. 2 (2004): 912–21. http://dx.doi.org/10.1128/jvi.78.2.912-921.2004.

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ABSTRACT One disadvantage of vesicular stomatitis virus G (VSV-G) pseudotyped lentivirus vectors for clinical application is inactivation of the vector by human serum complement. To prevent this, monomethoxypoly(ethylene) glycol was conjugated to a VSV-G-human immunodeficiency virus vector expressing Escherichia coli beta-galactosidase. The modification did not affect transduction efficiency in vitro and protected the vector from inactivation in complement-active human and mouse sera. Blood from mice dosed intravenously with either the unmodified or the PEGylated virus particles was assayed fo

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Katili, Moh Zulkifli, Yeni Herdiyeni, and Medria Kusuma Dewi Hardhienata. "Leveraging Biotic Interaction Knowledge Graph and Network Analysis to Uncover Insect Vectors of Plant Virus." Journal of Information Systems Engineering and Business Intelligence 10, no. 1 (2024): 94–109. http://dx.doi.org/10.20473/jisebi.10.1.94-109.

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Background: Insect vectors spread 80% of plant viruses, causing major agricultural production losses. Direct insect vector identification is difficult due to a wide range of hosts, limited detection methods, and high PCR costs and expertise. Currently, a biodiversity database named Global Biotic Interaction (GloBI) provides an opportunity to identify virus vectors using its data. Objective: This study aims to build an insect vector search engine that can construct an virus-insect-plant interaction knowledge graph, identify insect vectors using network analysis, and extend knowledge about ident

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Su, RuiJun, Rency L. Rosales, Martin Lochelt, and Neil C. Josephson. "Transduction of Primate Cells with Feline Foamy Virus Envelope Pseudotyped Prototype Foamy Virus Vectors." Blood 104, no. 11 (2004): 5276. http://dx.doi.org/10.1182/blood.v104.11.5276.5276.

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Abstract Because of their genetic and biological similarity to humans, non-human primates are the best pre-clinical models for testing the efficacy and safety of gene therapy systems. However, the presence of endogenous simian foamy virus infection in nearly all non-human primates kept in captivity complicates foamy virus (FV) vector stem cell transduction studies in these animals. A major concern is that repopulating cells exposed to FV vector stocks will elicit an immune response in non-human primate hosts. Though human serum does not inactivate prototype foamy virus (PFV) vectors, a one hou

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Russell, RA, G. Vassaux, P. Martin-Duque, and MO McClure. "Transient foamy virus vector production by adenovirus vectors." Gene Therapy 11, no. 3 (2004): 310–16. http://dx.doi.org/10.1038/sj.gt.3302177.

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Kenzhebekova, Roza, Alexandr Pozharskiy, Kamila Adilbayeva, and Dilyara Gritsenko. "Molecular Mechanisms of Potato Plant–Virus–Vector Interactions." Plants 14, no. 15 (2025): 2282. https://doi.org/10.3390/plants14152282.

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Viral infections and their vector dynamics pose a major threat to potatoes (Solanum tuberosum L.) worldwide, urgently needing an integrated understanding of the molecular and ecological interactions in this tripartite system. This review describes the major potato viruses, namely potato virus Y (PVY), the potato leafroll virus (PLRV), and potato virus X (PVX), with an emphasis on their infection and replication strategies in plants, as well as their movement within them. It also discusses plant responses to these viruses by uncovering RNA silencing, resistance (R) genes, and hormonal signaling

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Glockzin, Gabriel, Klaus Mantwill, Karsten Jurchott, et al. "Characterization of the Recombinant Adenovirus Vector AdYB-1: Implications for Oncolytic Vector Development." Journal of Virology 80, no. 8 (2006): 3904–11. http://dx.doi.org/10.1128/jvi.80.8.3904-3911.2006.

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ABSTRACT Conditionally replicating adenoviruses are a promising new modality for the treatment of cancer. However, early clinical trials demonstrate that the efficacy of current vectors is limited. Interestingly, DNA replication and production of viral particles do not always correlate with virus-mediated cell lysis and virus release depending on the vector utilized for infection. However, we have previously reported that nuclear accumulation of the human transcription factor YB-1 by regulating the adenoviral E2 late promoter facilitates viral DNA replication of E1-deleted adenovirus vectors w

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Kain, Morgan P., Eloise B. Skinner, Tejas S. Athni, Ana L. Ramirez, Erin A. Mordecai, and Andrew F. van den Hurk. "Not all mosquitoes are created equal: A synthesis of vector competence experiments reinforces virus associations of Australian mosquitoes." PLOS Neglected Tropical Diseases 16, no. 10 (2022): e0010768. http://dx.doi.org/10.1371/journal.pntd.0010768.

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The globalization of mosquito-borne arboviral diseases has placed more than half of the human population at risk. Understanding arbovirus ecology, including the role individual mosquito species play in virus transmission cycles, is critical for limiting disease. Canonical virus-vector groupings, such as Aedes- or Culex-associated flaviviruses, have historically been defined using virus detection in field-collected mosquitoes, mosquito feeding patterns, and vector competence, which quantifies the intrinsic ability of a mosquito to become infected with and transmit a virus during a subsequent bl

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Lee, Benjamin W., Liesl C. Oeller, and David W. Crowder. "Integrating Community Ecology into Models of Vector-Borne Virus Transmission." Plants 12, no. 12 (2023): 2335. http://dx.doi.org/10.3390/plants12122335.

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Vector-borne plant viruses are a diverse and dynamic threat to agriculture with hundreds of economically damaging viruses and insect vector species. Mathematical models have greatly increased our understanding of how alterations of vector life history and host–vector–pathogen interactions can affect virus transmission. However, insect vectors also interact with species such as predators and competitors in food webs, and these interactions affect vector population size and behaviors in ways that mediate virus transmission. Studies assessing how species’ interactions affect vector-borne pathogen

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Hariharan, Mangala J., David A. Driver, Kay Townsend, et al. "DNA Immunization against Herpes Simplex Virus: Enhanced Efficacy Using a Sindbis Virus-Based Vector." Journal of Virology 72, no. 2 (1998): 950–58. http://dx.doi.org/10.1128/jvi.72.2.950-958.1998.

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ABSTRACT Previously we reported the development of a plasmid DNA expression vector system derived from Sindbis virus (T. W. Dubensky, Jr., et al., J. Virol. 70:508–519, 1996). In vitro, such vectors exhibit high-level heterologous gene expression via self-amplifying cytoplasmic RNA replication. In the present study, we demonstrated the in vivo efficacy of the Sindbis virus-based pSIN vectors as DNA vaccines. A single intramuscular immunization of BALB/c mice with pSIN vectors expressing the glycoprotein B of herpes simplex virus type 1 induced a broad spectrum of immune responses, including vi

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Gildow, F. E., D. A. Shah, W. M. Sackett, T. Butzler, B. A. Nault, and S. J. Fleischer. "Transmission Efficiency of Cucumber mosaic virus by Aphids Associated with Virus Epidemics in Snap Bean." Phytopathology® 98, no. 11 (2008): 1233–41. http://dx.doi.org/10.1094/phyto-98-11-1233.

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Cucumber mosaic virus (CMV) is a major component of the virus complex that has become more pronounced in snap bean in the midwestern and northeastern United States since 2001. Multiple-vector-transfer tests were done to estimate the CMV transmission efficiencies (p) of the main aphid species identified in commercial snap bean fields in New York and Pennsylvania. The four most efficient vectors (p > 0.05) were Aphis gossypii, A. glycines, Acyrthosiphon pisum, and Therioaphis trifolii, which were all significant species in the migratory aphid populations in snap bean. Moderately efficient vec

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Waldetensai, Abate. "The Role of Aedes Mosquito in Yellow Fever Virus Transmission and its Control in Africas." Research & Reviews: Journal of Medical and Health Sciences 12, no. 3 (2023): 8. https://doi.org/10.4172/2319-9865.12.3.001.

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Throughout the world, many nuisance and potential transmitters of human and animal infections mosquitoes are distributing and occupying many biotopes. The female Aedes mosquitoes are commonly vectoring arboviruses by simply extracting blood from people, birds and other animals to obtain proteins needed to develop her eggs. Yellow fever virus, dengue virus, chikungunya virus, rift valley fever virus and zika virus are among the vector borne diseases. Understanding the competent vectors and the transmission cycle of yellow fever is the first step of collecting evidence since it provides suitable

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Patton, Gillian S., Otto Erlwein, and Myra O. McClure. "Cell-cycle dependence of foamy virus vectors." Journal of General Virology 85, no. 10 (2004): 2925–30. http://dx.doi.org/10.1099/vir.0.80210-0.

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Retroviruses differ in the extent to which they are dependent on host-cell proliferation for their replication, an aspect of their replication that impacts on their vector potential. Foamy viruses offer distinct advantages over other retroviruses for development as vectors for gene therapy. A vector derived from the prototypic foamy virus (PFV), formerly known as human foamy virus (HFV), transduced aphidicolin-arrested cells five- to tenfold more efficiently than one derived from murine leukemia virus (MLV), but several-fold less efficiently than a human immunodeficiency virus type 1 (HIV-1) v

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Ćuk, Marina, Zagorka Savić, Renata Iličić, and Ferenc Bagi. "Importance and epidemiology of tomato spotted wilt virus." Biljni lekar 49, no. 2 (2021): 148–57. http://dx.doi.org/10.5937/biljlek2102148c.

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Tomato spotted wilt virus (TSWV) is the most economically important plant viruses from genus Tospovirus. It has a polyphagous character and infects a wide range of very significant agricultural crops. Vectors of viruses are insects from order Thysanoptera (Thripidae) and till know eight species are known to transmit tospoviruses of which Frankliniella occidentalis is considered to be economically most important vector. TSWV is transmitted by thrips in a persistent and propagative manner. Relationship between vector and TSWV is very specific because vectors acquire the virus in the larval stage

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Romi, Hila, Oded Singer, Debora Rapaport, and Niza Frenkel. "Tamplicon-7, a Novel T-Lymphotropic Vector Derived from Human Herpesvirus 7." Journal of Virology 73, no. 8 (1999): 7001–7. http://dx.doi.org/10.1128/jvi.73.8.7001-7007.1999.

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ABSTRACT We describe the derivation of a novel T-cell-defective virus vector employing the human herpesvirus 7 (HHV-7). The new vector, designated Tamplicon-7, replicates in CD4+ T cells. The system is composed of a helper virus and defective virus genomes derived by the replication of the input Tamplicon vector. There are twocis-acting functions required for the replication and packaging of the defective virus genomes in the presence of the helper virus: the viral DNA replication origin and the composite cleavage and packaging signal, which directs the cleavage and packaging of defective viru

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Auerswald, Heidi, Pierre-Olivier Maquart, Véronique Chevalier, and Sebastien Boyer. "Mosquito Vector Competence for Japanese Encephalitis Virus." Viruses 13, no. 6 (2021): 1154. http://dx.doi.org/10.3390/v13061154.

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Japanese encephalitis virus (JEV) is a zoonotic pathogen mainly found in East and Southeast Asia and transmitted by mosquitoes. The objective of this review is to summarize the knowledge on the diversity of JEV mosquito vector species. Therefore, we systematically analyzed reports of JEV found in field-caught mosquitoes as well as experimental vector competence studies. Based on the investigated publications, we classified 14 species as confirmed vectors for JEV due to their documented experimental vector competence and evidence of JEV found in wild mosquitoes. Additionally, we identified 11 m

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Xin, Ke-Qin, Hiroaki Mizukami, Masashi Urabe, et al. "Induction of Robust Immune Responses against Human Immunodeficiency Virus Is Supported by the Inherent Tropism of Adeno-Associated Virus Type 5 forDendritic Cells." Journal of Virology 80, no. 24 (2006): 11899–910. http://dx.doi.org/10.1128/jvi.00890-06.

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ABSTRACT The ability of adeno-associated virus serotype 1 to 8 (AAV1 to AAV8) vectors expressing the human immunodeficiency virus type 1 (HIV-1) Env gp160 (AAV-HIV) to induce an immune response was evaluated in BALB/c mice. The AAV5 vector showed a higher tropism for both mouse and human dendritic cells (DCs) than did the AAV2 vector, whereas other AAV serotype vectors transduced DCs only poorly. AAV1, AAV5, AAV7, and AAV8 were more highly expressed in muscle cells than AAV2. An immunogenicity study of AAV serotypes indicates that AAV1, AAV5, AAV7, and AAV8 vectors expressing the Env gp160 gen

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Di Mattia, Jérémy, Faustine Ryckebusch, Marie-Stéphanie Vernerey, et al. "Co-Acquired Nanovirus and Geminivirus Exhibit a Contrasted Localization within Their Common Aphid Vector." Viruses 12, no. 3 (2020): 299. http://dx.doi.org/10.3390/v12030299.

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Single-stranded DNA (ssDNA) plant viruses belong to the families Geminiviridae and Nanoviridae. They are transmitted by Hemipteran insects in a circulative, mostly non-propagative, manner. While geminiviruses are transmitted by leafhoppers, treehoppers, whiteflies and aphids, nanoviruses are transmitted exclusively by aphids. Circulative transmission involves complex virus–vector interactions in which epithelial cells have to be crossed and defense mechanisms counteracted. Vector taxa are considered a relevant taxonomic criterion for virus classification, indicating that viruses can evolve spe

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Venter, Gert J., I. Hermanides, D. Majatladi, S. Boikanyo, and I. Wright. "Interactions vecteurs-virus : diversité des sérotypes et des souches de la peste équine africaine, et populations géographiques." Revue d’élevage et de médecine vétérinaire des pays tropicaux 62, no. 2-4 (2009): 107. http://dx.doi.org/10.19182/remvt.10023.

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The most abundant Culicoides species in an area is not inevitably the most competent vector species for a specific virus. Oral susceptibility, as an indicator of vector competence, is a measure of the portion of vectors taking a blood meal from an infected host that actually becomes infective. Cumulative laboratory oral susceptibility results from South Africa indicate a multivector potential for bluetongue virus (BTV) as well as for African horse sickness virus (AHSV). Considering the unique biology of potential vector competent Culicoides species one can appreciate the complex epidemiology

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Kaur, Navneet, Daniel K. Hasegawa, Kai-Shu Ling, and William M. Wintermantel. "Application of Genomics for Understanding Plant Virus-Insect Vector Interactions and Insect Vector Control." Phytopathology® 106, no. 10 (2016): 1213–22. http://dx.doi.org/10.1094/phyto-02-16-0111-fi.

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The relationships between plant viruses and their vectors have evolved over the millennia, and yet, studies on viruses began <150 years ago and investigations into the virus and vector interactions even more recently. The advent of next generation sequencing, including rapid genome and transcriptome analysis, methods for evaluation of small RNAs, and the related disciplines of proteomics and metabolomics offer a significant shift in the ability to elucidate molecular mechanisms involved in virus infection and transmission by insect vectors. Genomic technologies offer an unprecedented opport

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Gray, Stewart M., and Nanditta Banerjee. "Mechanisms of Arthropod Transmission of Plant and Animal Viruses." Microbiology and Molecular Biology Reviews 63, no. 1 (1999): 128–48. http://dx.doi.org/10.1128/mmbr.63.1.128-148.1999.

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SUMMARY A majority of the plant-infecting viruses and many of the animal-infecting viruses are dependent upon arthropod vectors for transmission between hosts and/or as alternative hosts. The viruses have evolved specific associations with their vectors, and we are beginning to understand the underlying mechanisms that regulate the virus transmission process. A majority of plant viruses are carried on the cuticle lining of a vector’s mouthparts or foregut. This initially appeared to be simple mechanical contamination, but it is now known to be a biologically complex interaction between specifi

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Eigenbrode, Sanford D., and Richard Gomulkiewicz. "Manipulation of Vector Host Preference by Pathogens: Implications for Virus Spread and Disease Management." Journal of Economic Entomology 115, no. 2 (2022): 387–400. http://dx.doi.org/10.1093/jee/toab261.

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Abstract Some plant pathogens manipulate the behavior and performance of their vectors, potentially enhancing pathogen spread. The implications are evolutionary and epidemiological but also economic for pathogens that cause disease in crops. Here we explore with models the effects of vector manipulation on crop yield loss to disease and on the economic returns for vector suppression. We use two frameworks, one that simulates the proportional occurrence of the pathogen in the vector population with the option to eliminate vectors by a single insecticidal treatment, and one that includes vector

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Sena-Esteves, Miguel, Yoshinaga Saeki, Sara M. Camp, E. Antonio Chiocca, and Xandra O. Breakefield. "Single-Step Conversion of Cells to Retrovirus Vector Producers with Herpes Simplex Virus–Epstein-Barr Virus Hybrid Amplicons." Journal of Virology 73, no. 12 (1999): 10426–39. http://dx.doi.org/10.1128/jvi.73.12.10426-10439.1999.

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ABSTRACT We report here on the development and characterization of a novel herpes simplex virus type 1 (HSV-1) amplicon-based vector system which takes advantage of the host range and retention properties of HSV–Epstein-Barr virus (EBV) hybrid amplicons to efficiently convert cells to retrovirus vector producer cells after single-step transduction. The retrovirus genes gag-pol andenv (GPE) and retroviral vector sequences were modified to minimize sequence overlap and cloned into an HSV-EBV hybrid amplicon. Retrovirus expression cassettes were used to generate the HSV-EBV-retrovirus hybrid vect

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Froissart, Rémy, Yannis Michalakis, and Stéphane Blanc. "Helper Component-Transcomplementation in the Vector Transmission of Plant Viruse." Phytopathology® 92, no. 6 (2002): 576–79. http://dx.doi.org/10.1094/phyto.2002.92.6.576.

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Plant viruses are most frequently transmitted from one host plant to another by vectors. In noncirculative vector transmission, the virus does not process through a cycle within the vector body. Instead, upon acquisition by the vector, viruses are retained in the mouth parts or the anterior gut; from there, they will be subsequently released in a new host plant. Two molecular strategies have been described for the virus—vector interaction. In the capsid strategy, the virus coat interacts directly with binding sites in the vector mouth parts, whereas an additional nonstructural protein, designa

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Langley, William A., Konrad C. Bradley, Zhu-Nan Li, Mary Ellen Smith, Matthias J. Schnell, and David A. Steinhauer. "Induction of Neutralizing Antibody Responses to Anthrax Protective Antigen by Using Influenza Virus Vectors: Implications for Disparate Immune System Priming Pathways." Journal of Virology 84, no. 16 (2010): 8300–8307. http://dx.doi.org/10.1128/jvi.00183-10.

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ABSTRACT Viral vectors based on influenza virus, rabies virus (RV), and vaccinia virus (VV) were used to express large polypeptide segments derived from the Bacillus anthracis protective antigen (PA). For the infectious influenza virus vector and recombinant VV constructs, the receptor binding domain (RBD or domain 4) or the lethal and edema factor binding domain (LEF or domain 1′) were engineered into functional chimeric hemagglutinin (HA) glycoproteins. In the case of the RV vector, the viral glycoprotein (G) was used as a carrier for RBD in an inactivated form of the vector. These construct

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Roberts, Anjeanette, Linda Buonocore, Ryan Price, John Forman, and John K. Rose. "Attenuated Vesicular Stomatitis Viruses as Vaccine Vectors." Journal of Virology 73, no. 5 (1999): 3723–32. http://dx.doi.org/10.1128/jvi.73.5.3723-3732.1999.

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ABSTRACT We showed previously that a single intranasal vaccination of mice with a recombinant vesicular stomatitis virus (VSV) expressing an influenza virus hemagglutinin (HA) protein provided complete protection from lethal challenge with influenza virus (A. Roberts, E. Kretzschmar, A. S. Perkins, J. Forman, R. Price, L. Buonocore, Y. Kawaoka, and J. K. Rose, J. Virol. 72:4704–4711, 1998). Because some pathogenesis was associated with the vector itself, in the present study we generated new VSV vectors expressing HA which are completely attenuated for pathogenesis in the mouse model. The firs

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Nakai, Hiroyuki, Sally Fuess, Theresa A. Storm, Shin-ichi Muramatsu, Yuko Nara, and Mark A. Kay. "Unrestricted Hepatocyte Transduction with Adeno-Associated Virus Serotype 8 Vectors in Mice." Journal of Virology 79, no. 1 (2005): 214–24. http://dx.doi.org/10.1128/jvi.79.1.214-224.2005.

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ABSTRACT Recombinant adeno-associated virus (rAAV) vectors can mediate long-term stable transduction in various target tissues. However, with rAAV serotype 2 (rAAV2) vectors, liver transduction is confined to only a small portion of hepatocytes even after administration of extremely high vector doses. In order to investigate whether rAAV vectors of other serotypes exhibit similar restricted liver transduction, we performed a dose-response study by injecting mice with β-galactosidase-expressing rAAV1 and rAAV8 vectors via the portal vein. The rAAV1 vector showed a blunted dose-response similar

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Shiau, Ai-Li, Pu-Ste Liu, and Chao-Liang Wu. "Novel Strategy for Generation and Titration of Recombinant Adeno-Associated Virus Vectors." Journal of Virology 79, no. 1 (2005): 193–201. http://dx.doi.org/10.1128/jvi.79.1.193-201.2005.

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ABSTRACT Recombinant adeno-associated virus (rAAV) vectors have many advantages for gene therapeutic applications compared with other vector systems. Several methods that use plasmids or helper viruses have been reported for the generation of rAAV vectors. Unfortunately, the preparation of large-scale rAAV stocks is labor-intensive. Moreover, the biological titration of rAAV is still difficult, which may limit its preclinical and clinical applications. For this study, we developed a novel strategy to generate and biologically titrate rAAV vectors. A recombinant pseudorabies virus (PrV) with de

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Lambrechts, Louis, and Thomas W. Scott. "Mode of transmission and the evolution of arbovirus virulence in mosquito vectors." Proceedings of the Royal Society B: Biological Sciences 276, no. 1660 (2009): 1369–78. http://dx.doi.org/10.1098/rspb.2008.1709.

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The traditional assumption that vector-borne pathogens should evolve towards a benign relationship with their arthropod vectors has been challenged on theoretical grounds and empirical evidence. However, in the case of arboviruses (arthropod-borne viruses), although a number of investigators have reported experimental evidence for virus-induced vector mortality, others have failed to detect any significant impact. Whether this variation in the observed level of arbovirus virulence depends on biological traits or experimental design is unclear. Here, we perform a meta-analysis of studies across

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Kahl, Christoph A., Jon Marsh, Joanne Fyffe, David A. Sanders, and Kenneth Cornetta. "Human Immunodeficiency Virus Type 1-Derived Lentivirus Vectors Pseudotyped with Envelope Glycoproteins Derived from Ross River Virus and Semliki Forest Virus." Journal of Virology 78, no. 3 (2004): 1421–30. http://dx.doi.org/10.1128/jvi.78.3.1421-1430.2004.

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ABSTRACT Ross River virus (RRV) and Semliki Forest virus (SFV) are two alphaviruses that have a high degree of amino acid homology, as well as a very broad host range. We show here that envelope glycoproteins derived from both viruses can pseudotype human immunodeficiency virus type 1 (HIV-1)-derived lentivirus vectors. Both RRV and SFV glycoproteins considerably expand the host range of the lentivirus vector, and vectors can be efficiently concentrated by ultracentrifugation. A systematic analysis comparing the alphaviral glycoproteins to the vesicular stomatitis virus glycoprotein (VSV-G) re

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Okada, Yoshimi. "Tobacco mosaic virus vector." Uirusu 37, no. 1 (1987): 33–40. http://dx.doi.org/10.2222/jsv.37.33.

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Molyavko, A. A., C. V. Zhevora, A. V. Marukhlenko, N. P. Borisova, and V. E. Torikov. "Potato Virus Vector Monitoring." Вестник Брянской государственной сельскохозяйственной академии, no. 2 (2022): 27–34. http://dx.doi.org/10.52691/2500-2651-2022-90-2-27-34.

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Coffey, Lark, Anna-Bella Failloux, and Scott Weaver. "Chikungunya Virus–Vector Interactions." Viruses 6, no. 11 (2014): 4628–63. http://dx.doi.org/10.3390/v6114628.

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Ash, C. "VIROLOGY: Virus, Vector, Vertebrate." Science 293, no. 5531 (2001): 763a—763. http://dx.doi.org/10.1126/science.293.5531.763a.

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Wang, Aiming, Tessa M. Burch-Smith, and Yi Li. "Focus on Cell Biology of Virus-Plant and Virus-Vector Interactions." Molecular Plant-Microbe Interactions® 33, no. 1 (2020): 5. http://dx.doi.org/10.1094/mpmi-11-19-0318-fi.

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A successful viral infection requires complex, compatible molecular interactions between the invading virus and the host. A better understanding of such interactions may assist in the development of novel approaches to control viral diseases for sustainable crop production. In the past decade, the cell biology of virus-host and virus-vector interactions has been one of the most exciting areas of research in the molecular plant-microbe field. This is partially attributed to the availability of powerful cell biology techniques, including imaging tools like confocal microscopy and electron micros

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Kauffman, Elizabeth B., and Laura D. Kramer. "Zika Virus Mosquito Vectors: Competence, Biology, and Vector Control." Journal of Infectious Diseases 216, suppl_10 (2017): S976—S990. http://dx.doi.org/10.1093/infdis/jix405.

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Smith, R. H. "Adeno-associated virus integration: virus versus vector." Gene Therapy 15, no. 11 (2008): 817–22. http://dx.doi.org/10.1038/gt.2008.55.

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Verdier, Maxime, Quentin Chesnais, Elodie Pirolles, Stéphane Blanc, and Martin Drucker. "The cauliflower mosaic virus transmission helper protein P2 modifies directly the probing behavior of the aphid vector Myzus persicae to facilitate transmission." PLoS 19, no. 2 (2023): e1011161. https://doi.org/10.5281/zenodo.7774575.

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<strong>Abstract</strong> There is growing evidence that plant viruses manipulate their hosts and vectors in ways that increase transmission. However, to date only few viral components underlying these phenomena have been identified. Here we show that cauliflower mosaic virus (CaMV) protein P2 modifies the feeding behavior of its aphid vector. P2 is necessary for CaMV transmission because it mediates binding of virus particles to the aphid mouthparts. We compared aphid feeding behavior on plants infected with the wild-type CaMV strain B-JI or with a deletion mutant strain, B-JIΔP2, which

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Mangeot, Philippe-Emmanuel, Didier Nègre, Bertrand Dubois, et al. "Development of Minimal Lentivirus Vectors Derived from Simian Immunodeficiency Virus (SIVmac251) and Their Use for Gene Transfer into Human Dendritic Cells." Journal of Virology 74, no. 18 (2000): 8307–15. http://dx.doi.org/10.1128/jvi.74.18.8307-8315.2000.

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ABSTRACT Lentivirus-derived vectors are very promising gene delivery systems since they are able to transduce nonproliferating differentiated cells, while murine leukemia virus-based vectors can only transduce cycling cells. Here we report the construction and characterization of highly efficient minimal vectors derived from simian immunodeficiency virus (SIVmac251). High-fidelity PCR amplification of DNA fragments was used to generate a minimal SIV vector formed from a 5′ cytomegalovirus early promoter, the 5′ viral sequences up to the 5′ end of gagrequired for reverse transcription and packa

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Montero-Astúa, Mauricio, Dorith Rotenberg, Alexandria Leach-Kieffaber, et al. "Disruption of Vector Transmission by a Plant-Expressed Viral Glycoprotein." Molecular Plant-Microbe Interactions® 27, no. 3 (2014): 296–304. http://dx.doi.org/10.1094/mpmi-09-13-0287-fi.

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Vector-borne viruses are a threat to human, animal, and plant health worldwide, requiring the development of novel strategies for their control. Tomato spotted wilt virus (TSWV) is one of the 10 most economically significant plant viruses and, together with other tospoviruses, is a threat to global food security. TSWV is transmitted by thrips, including the western flower thrips, Frankliniella occidentalis. Previously, we demonstrated that the TSWV glycoprotein GN binds to thrips vector midguts. We report here the development of transgenic plants that interfere with TSWV acquisition and transm

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