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Thematische Bibliographien / Vesicular transport proteins / Dissertationen

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Dissertationen zum Thema „Vesicular transport proteins“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 13. Februar 2022

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1

Barmark, Gunilla. "Functional studies of vesicular transport in yeast /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2005. http://epsilon.slu.se/2005110.pdf.

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2

Hansson, Stefan R. "The serotonin transporter and vesicular monoamine transporters during development." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945023.html.

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3

Merithew, Eric Lee. "Structural Basis for Rab5 Activation and Effector Specificity in Endosome Tethering: A Dissertation." eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/278.

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As critical regulators of vesicular trafficking, Rab proteins comprise the largest GTPase family, with thirty-eight functionally distinct members and another twenty isoforms in the human genome. Activated Rab GTPases interact with effector proteins involved in vesicle formation, transport, tethering, docking and fusion. The specificity of Rab interactions with effectors and regulatory factors plays a central role with respect to the fidelity of membrane trafficking. Rab recognition determinants and the mechanisms underlying interactions with structurally diverse regulatory factors and effector

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4

Zhuo, Yue. "Solution studies of protein complexes of the endocytic machinery : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1310415421&sid=2&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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5

Dubuke, Michelle L. "The Exocyst Subunit Sec6 Interacts with Assembled Exocytic Snare Complexes: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/868.

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In eukaryotic cells, membrane-bound vesicles carry cargo between intracellular compartments, to and from the cell surface, and to the extracellular environment. Many conserved families of proteins are required for properly localized vesicle fusion, including the multi-subunit tethering complexes and the SNARE complexes. These protein complexes work together to promote proper vesicle fusion in other trafficking pathways. Contrary to these other pathways, our lab previously suggested that the exocyst subunit Sec6, a component of the exocytosis-specific tethering complex, inhibited Sec9:Sso1 SNAR

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6

Dubuke, Michelle L. "The Exocyst Subunit Sec6 Interacts with Assembled Exocytic Snare Complexes: A Dissertation." eScholarship@UMMS, 2012. http://escholarship.umassmed.edu/gsbs_diss/868.

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In eukaryotic cells, membrane-bound vesicles carry cargo between intracellular compartments, to and from the cell surface, and to the extracellular environment. Many conserved families of proteins are required for properly localized vesicle fusion, including the multi-subunit tethering complexes and the SNARE complexes. These protein complexes work together to promote proper vesicle fusion in other trafficking pathways. Contrary to these other pathways, our lab previously suggested that the exocyst subunit Sec6, a component of the exocytosis-specific tethering complex, inhibited Sec9:Sso1 SNAR

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7

Custer, Kenneth Leybourne. "The roles of SV2 and SVOP proteins in regulating neurotransmission /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/10643.

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8

Brewer, Daniel Niron. "Elucidation of the Role of the Exocyst Subunit Sec6p in Exocytosis: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/446.

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Trafficking of protein and lipid cargo through the secretory pathway in eukaryotic cells is mediated by membrane-bound vesicles. Secretory vesicles are targeted to sites of exocytosis on the plasma membrane in part by a conserved multi-subunit protein complex termed the exocyst. In addition to tethering vesicles to the plasma membrane, the exocyst complex and components therein may also add a layer of regulation by directly controlling assembly of the SNARE complex, which is required for membrane fusion, as well as other regulatory factors such as Sec1p. In the past, we have shown that Sec6p i

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9

Georgiev, Alexander. "Membrane Stress and the Role of GYF Domain Proteins." Doctoral thesis, Stockholm : Department of Biochemistry and Biophysics, Stockholm university, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7764.

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10

Furgason, Melonnie Lynn Marie. "VPS45p as a Model System for Elucidation of SEC1/MUNC18 Protein Function: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/425.

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Vesicular trafficking, the movement of vesicles between organelles and the plasma membrane for secretion, consists of multiple highly regulated processes. Many protein families function as specificity and regulatory determinants to ensure correct vesicle targeting and timing of trafficking events. The SNARE proteins dock and fuse vesicles to their target membranes. Sec1/Munc18 (SM) proteins regulate membrane fusion through interactions with the SNAREs—SM proteins have been shown to act as both inhibitors and stimulators of SNARE assembly and membrane fusion. However, the details of these SM pr

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11

Franco, Rosana Banzato. "Efeitos da redução da função colinérgica na mecânica e na histopatologia pulmonar em modelo experimental de enfisema." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-27022014-145652/.

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Introdução: O enfisema pulmonar é o maior componente da doença pulmonar obstrutiva crônica (DPOC), é caracterizado pelo alargamento, destruição alveolar e inflamação do parênquima e vias aéreas pulmonares. A recente descrição do sistema colinérgico anti-inflamatório, um mecanismo neural que controla a inflamação por inibição de citocinas pró-inflamatórias, sugere uma importante participação deste sistema na fisiopatologia das doenças pulmonares. A acetilcolina (ACh), principal mediador deste sistema, é estocada em vesículas sinápticas pelo transportador vesicular de ACh (VAChT), proteína essen

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12

Valiathan, Rajeshwari Rajan. "Functional interactions of HIV-1 GAg with the cellular endocytic pathway /." Access full-text from WCMC, 2007. http://proquest.umi.com/pqdweb?did=1481666381&sid=16&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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13

Choi, Eun-Jung. "Comparison of the effects of a processing sequence and a nuclear export element on ribozyme activity in transfected cells." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0007401.

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Thesis (M.S.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 68 pages. Includes Vita. Includes bibliographical references.

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14

Younan, Patrick. "Identification and Characterization of SNAPIN as a Novel Antagonist of HIV-1 Egress: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/460.

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Vpu has been shown to possess two distinct roles in the pathogenesis of HIV. First, Vpu has been shown to down-regulate the expression of CD4 molecules at the plasma membrane of infected cells by targeting CD4 molecules for degradation in the endoplasmic reticulum. Second, Vpu promotes viral egress in specific cell lines termed non-permissive cells by mechanism that remain relatively unclear. Therefore, experiments were conducted in order to identify cellular factors involved in the Vpu-dependent phenotype. Using full-length Vpu as bait in yeast two-hybrid experiments, several candidate cellul

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15

Lee, Meng-Tse. "Catalytic Mechanisms in Sec7 and Vps9 Domain Exchange Factors for Arf and Rab GTPases: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/598.

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Vesicle budding, membrane trafficking, and lipid metabolism depend on the switching of Arf and Rab GTPases from the inactive GDP bound state to the active GTP bound state. However, Arf and Rab GTPases have intrinsic rates of GDP to GTP exchange that are much slower (hours to days) than the time scale of the relevant trafficking processes (seconds or less). In cells, the activation of Arf and Rab GTPases is tightly regulated by guanine nucleotide exchange factors (GEFs) with Sec7 or Vps9 domains, respectively. Full length Cytohesins, which have a domain architecture consisting of heptad repeats

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16

Pinheiro, Nathalia Montouro. "Efeito da redução da função colinérgica na mecânica pulmonar e na histopatologia pulmonar em modelo experimental de inflamação aguda induzida por instilação de LPS em camundongos geneticamente modificados." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-04082016-152420/.

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A lesão pulmonar aguda (LPA) é caracterizada por inflamação pulmonar de início súbito com recrutamento de polimorfonucleares e liberação de mediadores próinflamatórios. É uma condição grave que evolui com óbito em aproximadamente 40% dos casos. Diversos estudos que elucidaram a fisiopatologia da LPA, o tratamento ainda é insatisfatório. O sistema colinérgico anti-inflamatório foi descrito no pulmão e está relacionado a um reflexo via nervo vago que inibe a liberação de citocinas inflamatórias por efeitos relacionados a ação da acetilcolina em receptores nicotínicos. Nossa hipótese é de que a r

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17

Santana, Fernanda Paula Roncon. "Efeito da hipofunção colinérgica na mecânica e na histopatologia pulmonar em modelo experimental de inflamação pulmonar induzida por instilação de poluente em camundongos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-26012015-090146/.

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Os motores a diesel são bastante utilizados nos centros urbanos e sua queima é considerada um grande poluidor ambiental e tóxico para a saúde humana. Devido suas características químicas, as partículas de diesel atingem as vias aéreas mais distais, o que pode induzir inflamação pulmonar e piorar doenças como asma brônquica e enfisema pulmonar. Recentemente foi demonstrado por nosso grupo que o sistema colinérgico anti-inflamatório é um importante modulador da inflamação pulmonar. Assim, nosso objetivo no presente estudo foi avaliar se a deficiência colinérgica induzida por alteração genética p

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18

Watson-Siriboe, Abena. "MUTATION OF THE VESICULAR MONOAMINE TRANSPORTER-1 GENE ALTERS ITS PROTEIN PRODUCT." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/77.

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The vesicular monoamine transporter 1 (VMAT1) is essential for storage of monoamines, such as epinephrine and serotonin, in secretory vesicles of neuroendocrine cells. Recently the VMAT1 protein was detected in human and mouse brain, and mutations of the VMAT1 gene at single DNA nucleotides (single nucleotide polymorphisms or SNPs) were associated with schizophrenia. In this study, Chinese hamster ovarian cells were stably transfected with either human VMAT1 DNA (GenBank: #NM_003053.1 or DNA with the Thr4Pro SNP, which results in a threonine to proline change in amino acid number 4 of the VMAT

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19

Walter, Julia [Verfasser]. "The Autopalmitoylated Vesicular Transport Protein Bet3 : Biochemical and Fluorescence-based Characterization of Membrane and Substrate Binding / Julia Walter." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1155761081/34.

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20

Miranda, Claúdia Jeane Claudino de Pontes. "Avaliação da função e da histopatologia pulmonar em modelo experimental de inflamação pulmonar alérgica crônica: efeitos da redução da função colinérgica em camundongos geneticamente modificados." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-27072012-104906/.

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INTRODUÇÃO: A Asma Brônquica é caracterizada por obstrução ao fluxo aéreo, reversível ou não, e processo inflamatório pulmonar, caracterizado principalmente por eosinofilia. A persistência da inflamação pode induzir processo de reparo pulmonar associado à redução progressiva da função pulmonar. A recente descrição do sistema colinérgico anti-inflamatório, um mecanismo neural que suprime a resposta imune inata e controla a inflamação por inibição de citocinas proinflammatórias, e a detecção de alguns de seus componentes em células de vias aéreas sugerem uma importante participação deste sistema

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21

Nell, Sandra. "Vitamin E und der vesikuläre Transport : Untersuchungen zu den genregulatorischen Funktionen von Vitamin E mittels Microarray- und real time PCR-Analysen in der Maus und funktionellen in vitro Assays in RBL-2H3 Zellen." Phd thesis, Universität Potsdam, 2009. http://opus.kobv.de/ubp/volltexte/2009/3571/.

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Vitamin E wird immer noch als das wichtigste lipophile Antioxidanz in biologischen Membranen betrachtet. In den letzten Jahren hat sich jedoch der Schwerpunkt der Vitamin E-Forschung hin zu den nicht-antioxidativen Funktionen verlagert. Besonderes Interesse gilt dabei dem α-Tocopherol, der häufigsten Vitamin E-Form im Gewebe von Säugetieren, und seiner Rolle bei der Regulation der Genexpression. Das Ziel dieser Dissertation war die Untersuchung der genregulatorischen Funktionen von α-Tocoperol und die Identifizierung α-Tocopherol-sensitiver Gene in vivo. Zu diesem Zweck wurden Mäuse mit versch

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22

Tardivel-Safi, Meryem. "Les nanotubes comme nouvelle voie de transfert et de propagation de la protéine Tau pathologique." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S045/document.

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Récemment, le concept monofonctionnel de la protéine Tau en tant que protéine stabilisatrice des microtubules a été remis en cause. Ces nouvelles fonctions sont liées à de nouvelles localisations comme le noyau, la membrane, la synapse ou encore les vésicules. La localisation extracellulaire est particulièrement intéressante car elle pourrait intervenir dans la sécrétion de Tau et expliquer l’évolution hiérarchisée de certaines tauopathies sporadiques dont fait partie la maladie d’Alzheimer. La pathologie Tau peut être induite chez l’animal par injection intracrânienne d’espèces pathologiques

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23

Gezelius, Henrik. "Studies of Spinal Motor Control Networks in Genetically Modified Mouse Models." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109889.

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24

Carter, Hillary Hager. "Analysis of Bves function in vesicular transport and cell morphology." Diss., 2009. http://etd.library.vanderbilt.edu/available/etd-11302009-133224/.

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25

Dorfman, Julia. "Nuclear transport and regulation of the tumor suppressor LKB1." 2008. http://proquest.umi.com/pqdweb?did=1801444021&sid=1&Fmt=2&clientId=3507&RQT=309&VName=PQD.

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26

Benjamin, Jeremy. "Functions of the Yeast GTPase-Activating Proteins Age1 and Gcs1 for Post-Golgi Vesicular Transport." 2011. http://hdl.handle.net/10222/14218.

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Organelles within the endomembrane system of all eukaryotic cells exchange membrane lipids and proteins using membrane-bound transport vesicles. This highly conserved vesicular transport process is essential for life and is highly regulated. Much of this regulation is provided by small monomeric GTP-binding proteins such as Arf and Arl that act as molecular switches, cycling between inactive GDP-bound and active GTP-bound states. This cycle of GTP binding and hydrolysis is controlled by guanine-nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), respectively. I have inves

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27

Wang, Jing. "PI(4)-dependent recruitment of clathrin adaptors to the trans-Golgi Network." 2005. http://edissertations.library.swmed.edu/pdf/WangJ042905/WangJing.pdf.

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28

Arac-Ozkan, Demet. "Mechanism of synaptotagmin action in neurotransmitter release." 2005. http://edissertations.library.swmed.edu/pdf/Arac-OzkanD121905/Arac-OzkanDemet.pdf.

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29

Chen, Xiaocheng. "Unraveling the role of SNARE interactions in neurotransmitter release." 2005. http://edissertations.library.swmed.edu/pdf/ChenX050405/ChenXiaocheng.pdf.

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30

Her, Lu-Shiun. "Inhibition of nucleocytoplasmic transport by the matrix protein of vesicular stomatitis virus." 2001. http://www.library.wisc.edu/databases/connect/dissertations.html.

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31

Petrů, Markéta. "Eukaryotické proteiny v patogenní bakterii Legionella pneumophila." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-321126.

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32

Rube, Peter. "Atg26 is involved in selective autophagy of the major coat protein Gag of the S. cerevisiae virus L-A." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0028-869E-9.

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