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Zeitschriftenartikel zum Thema „XSpectra“

Autor: Grafiati

Veröffentlicht am 25. Mai 2024

Zuletzt aktualisiert am 31. Juli 2025

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1

Quercia, J., F. Mele, D. Macera, B. Arcaini, B. Garavelli, and G. Bertuccio. "Experimental characterization of a fast X-ray spectroscopic imager module using the ALTAIR P3 ASIC for real-time contaminants detection." Journal of Instrumentation 18, no. 01 (2023): C01064. http://dx.doi.org/10.1088/1748-0221/18/01/c01064.

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Abstract X-ray imagers with spectroscopic capabilities and high photon count rates are finding promising applications in industrial real-time inspection systems. In this context, XSpectra® combines a CdTe-based linear energy-resolved photon counting (ERPC) pixel sensor with real-time image processing techniques to detect low and high density contaminants. The detection unit makes use of a new analog read-out ASIC that has been designed by Politecnico di Milano to meet strict application requirements both in energy resolution and achievable photon count rate. A room-temperature low-rate spectro

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Buniatyan, Armen. "Measurement of Feynman-xspectra of photons and neutrons in the very forward direction in deep-inelastic scattering at HERA." EPJ Web of Conferences 99 (2015): 13002. http://dx.doi.org/10.1051/epjconf/20159913002.

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Beck, Michael Thomas, Gregor Rugel, Julia Reinfelder, et al. "Quantitative Analysis of Multimodal Skeletal SPECT/CT Reconstructions in Diagnosing Medication-related Osteonecrosis of the Jaw." Nuklearmedizin - NuclearMedicine 60, no. 06 (2021): 403–10. http://dx.doi.org/10.1055/a-1525-7621.

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Abstract Aim Our goal was to assess visual and quantitative aspects of multimodal skeletal SPECT/CT reconstructions (recon) in differentiating necrotic and healthy bone of patients with suspected MRONJ. Methods Prior to surgery, 20 patients with suspected MRONJ underwent SPECT/CT of the jaw 3–4 hours after injection of Tc-99m-DPD (622±112.4 MBq). SPECT/CT data were reconstructed using the multimodal xSPECT Bone and xSPECT Quant algorithms as well as the OSEM-algorithm FLASH 3D. For analysis, we divided the jaw into 12 separate regions. Both xSPECT Bone and FLASH 3D datasets were scored on a fo

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Ignacchiti Lacerda, Marcela, Bruna Costa Rodrigues, Guilherme Ramires de Jesús, et al. "The association between active proliferative lupus nephritis during pregnancy and small for gestational age newborns." Clinical and Experimental Rheumatology 39, no. 5 (2021): 1043–48. http://dx.doi.org/10.55563/clinexprheumatol/xspect.

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Ungania, Sara, Marco D’Arienzo, Sandro Nocentini, et al. "Optimization of 99mTc-MAA SPECT/CT Imaging for 90Y Radioembolization Using a 3D-Printed Phantom." Applied Sciences 12, no. 19 (2022): 10022. http://dx.doi.org/10.3390/app121910022.

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Radioembolization (RE) with 90Y-microspheres has gained widespread acceptance as a safe and effective technique for treating liver malignancies. Accurate quantification in RE is a key step in treatment planning optimization and is becoming a pressing issue in light of the Directive 2013/59/EURATOM. The aim of this study was to develop a SPECT/CT imaging protocol for quantitative imaging optimization in RE based on cutting edge imaging technology (Symbia IntevoTM system provided with the innovative xSPECT software) and a novel anthropomorphic 3D-printed phantom. In the present study, 99mTc-labe

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Gumbricht, Thomas, and Sonia Meller. "The dynamics of soil health." Open Access Government 44, no. 1 (2024): 444–45. http://dx.doi.org/10.56367/oag-044-11173.

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The dynamics of soil health Thomas Gumbricht from Stockholm University and xSpectre, with Sonia Meller from Digit Soil, discuss what we need to know about understanding the dynamics of soil health. Soils are formed by mineral debris, organic matter, water and living organisms. The soil ecosystem takes millennia to form and is sustained by a web of interplay both within the soil and with the vegetation ecosystem it harbours. Our human society wholly depends on soil for food, fodder, fibre, water cleaning, and climate control. But we are mismanaging soils, and in Europe, the majority of soils ar

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Christopher, Hoog, Verrecchia-Ramos Emilie, Dejust Sebastien, et al. "Implementation of xSPECT, xSPECT bone and Broadquant from literature, clinical survey and innovative phantom study with task-based image quality assessment." Physica Medica 112 (August 2023): 102611. http://dx.doi.org/10.1016/j.ejmp.2023.102611.

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Schnopper, Herbert W. "XSPECT: A Telescope/Spectrometer System on SPECTRUM RÖNTGEN GAMMA." International Astronomical Union Colloquium 115 (1990): 307–17. http://dx.doi.org/10.1017/s0252921100012513.

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AbstractThe SPECTRUM RÖNTGEN-GAMMA mission is being developed by the Babakin Center (BC) together with the Space Research Institute (IKI) of the Academy of Sciences, USSR and is scheduled for launch in 1993. Mission objectives include broad and narrow band imaging spectroscopy over a wide range of energies from the EUV through gamma rays with particular emphasis on the study of extragalactic objects. The Danish Space Research Institute (DSRI) BC and IKI share the responsibility for the preparation of the XSPECT system. Two thin foil telescopes which are conical shell approximations to Wolter 1

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Tran-Gia, Johannes, and Michael Lassmann. "Characterization of Noise and Resolution for Quantitative 177Lu SPECT/CT with xSPECT Quant." Journal of Nuclear Medicine 60, no. 1 (2018): 50–59. http://dx.doi.org/10.2967/jnumed.118.211094.

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Armstrong, Ian S., and Sandra A. Hoffmann. "Activity concentration measurements using a conjugate gradient (Siemens xSPECT) reconstruction algorithm in SPECT/CT." Nuclear Medicine Communications 37, no. 11 (2016): 1212–17. http://dx.doi.org/10.1097/mnm.0000000000000586.

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Freije, Rebeca Feixas, Lucia Gracia Martínez-Caro, Raquel Arroyo de la Cruz, et al. "CO034 - VALORACIÓN CUANTITATIVA DE LA AMILOIDOSIS CARDIACA CON 99MTC-DPD USANDO EL ALGORITMO DE RECONSTRUCCIÓN XSPECT." Revista Española de Medicina Nuclear e Imagen Molecular 42 (May 2023): S176. http://dx.doi.org/10.1016/s2253-654x(23)00300-1.

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Chen, Ew-Jun, Teik Hin Tan, and Ming Tsuey Chew. "Superscan: Superiority of xSPECT/CT over OSEM SPECT/CT in bone scans of prostate cancer patients." Radiation Physics and Chemistry 178 (January 2021): 108998. http://dx.doi.org/10.1016/j.radphyschem.2020.108998.

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Tristram, M., J. F. Macias-Perez, C. Renault, and D. Santos. "XSPECT, estimation of the angular power spectrum by computing cross-power spectra with analytical error bars." Monthly Notices of the Royal Astronomical Society 358, no. 3 (2005): 833–42. http://dx.doi.org/10.1111/j.1365-2966.2005.08760.x.

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Avalon, Juan Carlo, Jacob Fuqua, Seth Deskins, et al. "UTILIZING XSPECT/CT DERIVED STANDARDIZED UPTAKE VALUES TO BETTER QUANTIFY DISEASE BURDEN IN PATIENTS WITH TRANSTHYRETIN-RELATED AMYLOIDOSIS." Journal of the American College of Cardiology 77, no. 18 (2021): 1403. http://dx.doi.org/10.1016/s0735-1097(21)02761-3.

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Armstrong, Ian S. "Spatial dependence of activity concentration recovery for a conjugate gradient (Siemens xSPECT) algorithm using manufacturer-defined reconstruction presets." Nuclear Medicine Communications 40, no. 3 (2019): 287–93. http://dx.doi.org/10.1097/mnm.0000000000000960.

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De Laroche, R., P. Robin, J. P. Malhaire, et al. "Faisabilité d’utilisation de xSPECT-QUANT® en TEMP/TDM osseuse pour l’évaluation thérapeutique des cancers prostatiques métastatiques osseux." Médecine Nucléaire 39, no. 3 (2015): 254. http://dx.doi.org/10.1016/j.mednuc.2015.03.168.

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De Laroche, R., E. Simon, N. Suignard, et al. "Intérêt de l’analyse quantitative en TEMP/TDM osseuse par xSPECT Quant ® (Siemens) en bilan préchirurgical de gonarthrose." Médecine Nucléaire 41, no. 3 (2017): 168. http://dx.doi.org/10.1016/j.mednuc.2017.02.079.

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Ichikawa, Hajime, Noriaki Miyaji, Masahisa Onoguchi, et al. "Feasibility of ultra-high-speed acquisition in xSPECT bone algorithm: a phantom study with advanced bone SPECT-specific phantom." Annals of Nuclear Medicine 36, no. 2 (2021): 183–90. http://dx.doi.org/10.1007/s12149-021-01689-2.

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Delcroix, O., P. Robin, M. Gouillou, et al. "The new SPECT/CT reconstruction algorithm xSPECT Bone ® : Reliability and accuracy in daily practice for non-oncologic bone diseases." Médecine Nucléaire 41, no. 3 (2017): 158. http://dx.doi.org/10.1016/j.mednuc.2017.02.055.

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Vilhu, O., and A. Collier Cameron. "X-ray Spectral Diagnostics for Coronal Loops in the Active K Dwarf AB Doradus." International Astronomical Union Colloquium 115 (1990): 132–35. http://dx.doi.org/10.1017/s0252921100012239.

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AbstractWe discuss theoretical X-ray spectra for coronal loop models in the rapidly rotating young K dwarf AB Doradus (HD 36705), as a typical representative of active X-ray bright stars. The loop models are based on EXOSAT and IUE observations, and further motivated by a possible connection between the observed X-ray flares and co-rotating clouds of neutral hydrogen (a few/day). The resulting synthetic spectra between 0.5 – 7 keV can be approximated by a linear combination of three distinct temperature components. Two components are sufficient between 0.5 – 2.5 keV. Below 0.1 keV the loop spe

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Lima, Thiago V. M., Ujwal Bhure, Maria de Sol Pérez Lago, et al. "Impact of metal implants on xSPECT/CT Bone reconstruction: the “shining metal artefact”." European Journal of Hybrid Imaging 4, no. 1 (2020). http://dx.doi.org/10.1186/s41824-020-00087-7.

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Abstract Background Novel reconstruction algorithms, such as xSPECT Bone, are gaining more and more importance in Nuclear Medicine. With xSPECT Bone, the reconstructed emission image is enhanced by the information obtained in the corresponding CT image. The CT defines tissue classes according to the Hounsfield units. In the iterative reconstruction, each tissue class is handled separately in the forward projection step, and all together in the back projection step. As a consequence, xSPECT Bone reconstruction generates images with improved boundary delineation and better anatomic representatio

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Nguyễn, Tuấn Long, Thành Công Phạm та Xuân Ngọc Lê. "NGHIÊN CỨU ỨNG DỤNG CÔNG NGHỆ XỬ LÝ ẢNH XSPECT TRONG GHI HÌNH PHÓNG XẠ SPECT/CT". Tạp chí Y học Việt Nam 526, № 2 (2023). http://dx.doi.org/10.51298/vmj.v526i2.5512.

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Mục tiêu của nghiên cứu: Ứng dụng công nghệ xử lý ảnh xSPECT trong ghi hình phóng xạ SPECT/CT. Đối tượng và phương pháp nghiên cứu: Máy SPECT/CT của hãng Siemens, Đức. Phàn mềm xSPECT; Phan-tom nước; Ghi hình SPECT/CT với thuốc phóng xạ 99mTc-MDP trên bệnh nhân ung thư biểu mô tuyến tiền liệt. Kết quả nghiên cứu: Kết quả dụng bốn phương pháp tái tạo: xSPECT Quant (xQ); xSPECT Xương™ (xB); Flash 3D (F3D); OSEM, cho thấy lập mô hình ma trận hệ thống chính xác hơn là lược đồ cập nhật. Kết quả định lượng của nền và 6 hình cầu bằng cách sử dụng xE, xQ và xB với lấy mẫu góc 3 độ và 6 độ sau nhiều lầ

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Braun, Martin, Michal Cachovan, Felix Kaul, et al. "Accuracy comparison of various quantitative [99mTc]Tc-DPD SPECT/CT reconstruction techniques in patients with symptomatic hip and knee joint prostheses." EJNMMI Research 11, no. 1 (2021). http://dx.doi.org/10.1186/s13550-021-00794-7.

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Abstract Background There is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of different 99mTc-dicarboxypropandiphosphate ([99mTc]Tc-DPD) SPECT/CT quantification tools for the detection of loose prostheses in patients with painful hip and knee arthroplasties. Methods Quantitative reconstruction of mineral phase SPECT data was performed using Siemens xSPECT-Quant and xSPECT-Bone, with and without metal artefact reduction (iMAR) of CT-data. Quantitative data (SUVmax values) were compared to intraoperative diagnosis or clini

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Ebrahimifard, Ali, Hossein Rajabi, Parham Geramifar, Markus Luster, Behrooz Hooshyar Yousefi, and Robin de Nijs. "The impact of the xSPECT reconstruction algorithms on the recovery coefficients value for small tumors: a phantom study with 177Lu." Nuklearmedizin - NuclearMedicine, December 11, 2024. https://doi.org/10.1055/a-2418-2486.

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AbstractQuantifying small tumors is still a challenge due to the partial volume effect (PVE). Although iterative reconstruction had promising results with a better recovery coefficient (RC), it suffers from the PVE. RC values typically depend on the reconstruction method, which may affect on 177Lu quantifying. In this study, we investigated the effect of different reconstruction methods on RC values for 177Lu SPECT/CT images.A water-filled cylindrical polymethylmethacrylate (PMMA) phantom without background radioactivity with two solid cylinders which represent the bone and soft tissue equival

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Perriraz, Jérémy, Daniel Abler, Paolo Salvioni Chiabotti, et al. "A radiomics-based analysis of functional dopaminergic scintigraphic imaging for the diagnosis of dementia with Lewy bodies." Neurodegenerative Diseases, July 10, 2025, 1–17. https://doi.org/10.1159/000547261.

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Introduction Radiomics features, a technique based on quantitative image analysis, can be used to capture tissue and lesion characteristics, such as heterogeneity and shape. Using functional dopaminergic scintigraphy, we aim to study the value of radiomics features in predicting the diagnosis of dementia with Lewy bodies (DLB). Materials and methods We retrospectively analyzed 74 patients (29 F and 45 M, mean age 71.6±9.2 ) investigated in the Leenaards Memory Center (Lausanne University Hospital) for DLB who underwent quantitative I-123-ioflupane SPECT/CT (DaTscan). All scanned examinations h

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Hasegawa, Daisuke, Toshihiro Iguchi, Masayasu Takatani, Kotaro Tokunaga, Takuma Minoda, and Masahiro Miyai. "Effect of single-photon emission computed tomography acquisition method and sampling angles on image quality and quantitative accuracy in xSPECT-reconstructed images." Nuclear Medicine Communications, August 5, 2024. http://dx.doi.org/10.1097/mnm.0000000000001883.

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Objective The aim of this study was to evaluate the effects of the single-photon emission computed tomography (SPECT) acquisition method and sampling angles on the qualitative and quantitative interpretations of xSPECT-reconstructed images. Methods The spatial resolution was evaluated using a JSP phantom, and the uniformity and quantitative accuracy were verified with a NEMA IEC Body Phantom using an SIEMENS Symbia Intevo SPECT/computed tomography system. SPECT was performed using three acquisition methods (step-and-shoot, continuous, and acquire during the step), and the sampling angles were

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Kugler, Amelie, Torsten Kuwert, Philipp Ritt, and Andreas Grings. "Influence of CT metal artifact reduction on SPECT/CT quantification of bone scintigraphy – Retrospective study for selected types of metal implants." Nuklearmedizin - NuclearMedicine, August 9, 2022. http://dx.doi.org/10.1055/a-1883-9281.

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Abstract Aim Implanted metal prostheses can cause severe artifacts in reconstructed computed tomography (CT) images. To reduce the diagnostic impact of these artifacts and improve attenuation correction in single photon emission computed tomography (SPECT), an algorithm of iterative metal artifact reduction (iMAR) for SPECT/CT systems was developed. The aims of this study were (a) to assess the difference in visual image quality by comparing CT and SPECT images reconstructed with and without iMAR and (b) to determine the influence of iMAR on quantitative 99mTc-uptake in SPECT/CT. Methods This

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Wang, Xiaojin, Guichao Liu, Zhanyu Li, et al. "Prospective study of ^99mTc‐3PRGD₂ SPECT/CT diagnosing metastatic lymph nodes in esophageal squamous cell carcinoma." Thoracic Cancer, August 14, 2024. http://dx.doi.org/10.1111/1759-7714.15421.

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AbstractBackgroundLymph node (LN) metastasis is a significant prognostic factor for esophageal squamous cell carcinoma (ESCC), and there are no satisfactory methods for accurately predicting metastatic LNs. The present study aimed to assess the efficacy of 99mTc‐3PRGD2 single‐photon emission computed tomography (SPECT)/computed tomography (CT) for diagnosing metastatic LNs in ESCC.MethodsA total of 15 enrolled patients with ESCC underwent 99mTc‐3PRGD2 SPECT/CT and 18F‐fluorodeoxyglucose positron emission tomography‐computed tomography (18F‐FDG PET/CT) examinations preoperatively. High‐definiti

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Miyaji, Noriaki, Kenta Miwa, Ayaka Tokiwa, et al. "Phantom and clinical evaluation of bone SPECT/CT image reconstruction with xSPECT algorithm." EJNMMI Research 10, no. 1 (2020). http://dx.doi.org/10.1186/s13550-020-00659-5.

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Nakajima, Kenichi, Takayuki Shibutani, Francesc Massanes, et al. "Myocardial perfusion imaging with retrospective gating and integrated correction of attenuation, scatter, respiration, motion, and arrhythmia." Journal of Nuclear Cardiology, September 27, 2023. http://dx.doi.org/10.1007/s12350-023-03374-5.

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Abstract Background Absolute quantitative myocardial perfusion SPECT requires addressing of aleatory and epistemic uncertainties in conjunction with providing image quality sufficient for lesion detection and characterization. Iterative reconstruction methods enable the mitigation of the root causes of image degradation. This study aimed to determine the feasibility of a new SPECT/CT method with integrated corrections attempting to enable absolute quantitative cardiac imaging (xSPECT Cardiac; xSC). Methods We compared images of prototype xSC and conventional SPECT (Flash3DTM) acquired at rest

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Jreige, Mario, Nicolas Hall, Fabio Becce, et al. "A novel approach for fibrous dysplasia assessment using combined planar and quantitative SPECT/CT analysis of Tc-99m-diphosphonate bone scan in correlation with biological bone turnover markers of disease activity." Frontiers in Medicine 9 (November 25, 2022). http://dx.doi.org/10.3389/fmed.2022.1050854.

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PurposeTo investigate the emerging role of Tc-99m-labeled diphosphonate (Tc-99m-DPD) uptake quantification by SPECT/CT in fibrous dysplasia (FD) bone lesions and its correlation with biological bone turnover markers (BTMs) of disease activity.Materials and methodsSeven patients (49 ± 16 years) with a confirmed diagnosis of FD were included in this retrospective study. Bone scans with Tc-99m-DPD and quantitative SPECT/CT (xSPECT/CT) were performed. SUVmax (maximum standard unit value) and SUVmean (mean standard unit value) were measured in all FD bone lesions. The skeletal burden score (SBS) wa

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Duncan, Iain, and Nicholas Ingold. "The clinical value of xSPECT/CT Bone versus SPECT/CT. A prospective comparison of 200 scans." European Journal of Hybrid Imaging 2, no. 1 (2018). http://dx.doi.org/10.1186/s41824-017-0024-9.

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Lam, Tuyet Oanh, and Andy Young. "Fabrication of 3D printed hollow spheres for quality control and feasibility for use with xSPECT bone." Physical and Engineering Sciences in Medicine, December 30, 2024. https://doi.org/10.1007/s13246-024-01496-9.

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Shibutani, Takayuki, Takahiro Konishi, Hajime Ichikawa, et al. "Detectability of cold tumors by xSPECT bone technology compared with hot tumors: a supine phantom study." Physical and Engineering Sciences in Medicine, December 20, 2023. http://dx.doi.org/10.1007/s13246-023-01364-y.

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Salas-Ramirez, Maikol, Julian Leube, Michael Lassmann, and Johannes Tran-Gia. "Effect of kilovoltage and quality reference mAs on CT-based attenuation correction in 177Lu SPECT/CT imaging: a phantom study." EJNMMI Physics 11, no. 1 (2024). http://dx.doi.org/10.1186/s40658-024-00622-6.

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Abstract Introduction CT-based attenuation correction (CT-AC) plays a major role in accurate activity quantification by SPECT/CT imaging. However, the effect of kilovoltage peak (kVp) and quality-reference mAs (QRM) on the attenuation coefficient image (μ-map) and volume CT dose index (CTDIvol) have not yet been systematically evaluated. Therefore, the aim of this study was to fill this gap and investigate the influence of kVp and QRM on CT-AC in 177Lu SPECT/CT imaging. Methods Seventy low-dose CT acquisitions of an Electron Density Phantom (seventeen inserts of nine tissue-equivalent material

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Sézin, G., P. Lalire, C. Hoog, et al. "Évaluation de la modalité de reconstruction xSPECT bone dans la détection de lésions osseuses secondaires en scintigraphie osseuse." Médecine Nucléaire, January 2024. http://dx.doi.org/10.1016/j.mednuc.2023.09.009.

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Wang, Xiaoya, Guanyun Wang, Ziang Zhou, Ying Kan, and Jigang Yang. "The value of 123I-MIBG xSPECT/CT quantitative parameters in the diagnosis of bone metastasis in pediatric neuroblastoma patients." Quantitative Imaging in Medicine and Surgery, January 2023, 0. https://doi.org/10.21037/qims-24-1251.

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Westlund Gotby, Lovisa E. L., Daphne Lobeek, Joey Roosen, Maarten de Bakker, Mark W. Konijnenberg, and J. Frank W. Nijsen. "Accuracy of holmium-166 SPECT/CT quantification over a large range of activities." EJNMMI Physics 11, no. 1 (2024). http://dx.doi.org/10.1186/s40658-024-00683-7.

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Abstract Background Quantitative imaging is a crucial step for dosimetry in radionuclide therapies. Traditionally, SPECT/CT imaging is quantified based on scanner-specific conversion factors or self-calibration, but recently absolute quantification methods have been introduced in commercial SPECT reconstruction software (Broad Quantification, Siemens Healthineers). In this phantom study we investigate the accuracy of three quantification methods for holmium-166 SPECT/CT imaging, and provide recommendations for clinical dosimetry. Methods One cylindrical phantom, filled with a homogeneous holmi

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Mallaev, M., A.-F. Chirindel, G. Nicolas, et al. "3D-quantitated lung perfusion SPECT/CT: Impact on intended management compared to lung perfusion scan in marginal candidates for lung resection surgery." British Journal of Surgery 109, Supplement_3 (2022). http://dx.doi.org/10.1093/bjs/znac185.001.

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Abstract Objective Based on previous studies, single-photon emission computed tomography/computed tomography (SPECT/CT) has been proven to be more accurate and reproducible than planar lung perfusion scintigraphy. We conducted a study to evaluate the impact of 3D-quantitated lung perfusion SPECT/CT on intended management in candidates for lung resection surgery. Methods Retrospective study including candidates for lung resection surgery with lung perfusion imaging. Patients underwent preoperative evaluation according to ERS/ESTS algorithm. The lobar contribution to the total lung perfusion was

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Tabotta, Flavian, Mario Jreige, Niklaus Schaefer, Fabio Becce, John O. Prior, and Marie Nicod Lalonde. "Quantitative bone SPECT/CT: high specificity for identification of prostate cancer bone metastases." BMC Musculoskeletal Disorders 20, no. 1 (2019). http://dx.doi.org/10.1186/s12891-019-3001-6.

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Abstract Purpose Bone scintigraphy with 99mTc-labeled diphosphonates can identify prostate cancer bone metastases with high sensitivity, but relatively low specificity, because benign conditions such as osteoarthritis can also trigger osteoblastic reactions. We aimed to investigate the diagnostic performance of 99mTc-2,3-dicarboxy propane-1,1-diphosphonate (99mTc-DPD) uptake quantification by single-photon emission computed tomography coupled with computed tomography (SPECT/CT) for distinguishing prostate cancer bone metastases from spinal and pelvic osteoarthritic lesions. Methods We retrospe

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Hughes, Daniel Johnathan, Gitasha Chand, Jessica Johnson, et al. "Inter-rater and intra-rater agreement of [99mTc]-labelled NM-01, a single-domain programmed death-ligand 1 (PD-L1) antibody, using quantitative SPECT/CT in non-small cell lung cancer." EJNMMI Research 13, no. 1 (2023). http://dx.doi.org/10.1186/s13550-023-01002-4.

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Abstract Background Immune checkpoint inhibitors, including those against programmed cell death protein-1 (PD-1) or its ligand (PD-L1), are routinely used to treat non-small cell lung cancer (NSCLC). PD-L1 is a validated prognostic and predictive immunohistochemical biomarker of anti-PD-1/PD-L1 therapy but displays temporospatial heterogeneity of expression. Non-invasive radiopharmaceutical techniques, including technetium-99m [99mTc]-labelled anti-PD-L1 single-domain antibody (NM-01) SPECT/CT, have the potential to improve the predictive value of PD-L1 assessment. This study aims to determine

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Robertson, Matthew S., Yating Wang, SuChun Cheng, et al. "Quantification of normal bone and osseous metastases in castration-resistant prostate cancer using SPECT/CT with xSPECT Quant: prospective imaging sub-study of a phase 2 clinical trial investigating the combination of pembrolizumab plus radium-223 compared to radium-223 alone." La radiologia medica, November 20, 2024. http://dx.doi.org/10.1007/s11547-024-01931-7.

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