Bibliografías temáticas / Adenosine A2B receptor

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Literatura académica sobre el tema "Adenosine A2B receptor"

Autor: Grafiati
Publicado: 10 de marzo de 2023
Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "Adenosine A2B receptor"

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Wolska, Nina, and Marcin Rozalski. "Blood Platelet Adenosine Receptors as Potential Targets for Anti-Platelet Therapy." International Journal of Molecular Sciences 20, no. 21 (2019): 5475. http://dx.doi.org/10.3390/ijms20215475.

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Adenosine receptors are a subfamily of highly-conserved G-protein coupled receptors. They are found in the membranes of various human cells and play many physiological functions. Blood platelets express two (A2A and A2B) of the four known adenosine receptor subtypes (A1, A2A, A2B, and A3). Agonization of these receptors results in an enhanced intracellular cAMP and the inhibition of platelet activation and aggregation. Therefore, adenosine receptors A2A and A2B could be targets for anti-platelet therapy, especially under circumstances when classic therapy based on antagonizing the purinergic r
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Feng, Ming-Guo, and L. Gabriel Navar. "Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation." American Journal of Physiology-Renal Physiology 299, no. 2 (2010): F310—F315. http://dx.doi.org/10.1152/ajprenal.00149.2010.

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Adenosine is an important paracrine agent regulating renal vascular tone via adenosine A1 and A2 receptors. While A2B receptor message and protein have been localized to preglomerular vessels, functional evidence on the role of A2B receptors in mediating the vasodilator action of adenosine on afferent arterioles is not available. The present study determined the role of A2B receptors in mediating the afferent arteriolar dilation and compared the effects of A2B and A2A receptor blockade on afferent arterioles. We used the rat in vitro blood-perfused juxtamedullary nephron technique combined wit
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Gebremedhin, Debebe, Brian Weinberger, David Lourim, and David R. Harder. "Adenosine Can Mediate its Actions through Generation of Reactive Oxygen Species." Journal of Cerebral Blood Flow & Metabolism 30, no. 10 (2010): 1777–90. http://dx.doi.org/10.1038/jcbfm.2010.70.

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Adenosine is an important cerebral vasodilator, but mediating mechanisms are not understood. We investigated the expression of adenosine receptor subtypes in isolated cerebral arterial muscle cells (CAMCs), and their role in adenosine-induced superoxide (O2−) generation and reduction in cerebral arterial tone. Reverse transcriptase-PCR, western blotting, and immunofluorescence studies have shown that CAMCs express transcript and protein for A1, A2A, A2B, and A3 adenosine receptors. Stimulation of CAMCs with adenosine or the A2A agonist CGS-21680 increased the generation of O2− that was attenua
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Zaynagetdinov, Rinat, Kai Schiemann, Kalyan Nallaparaju, et al. "Abstract 3499: M1069 as dual A2A/A2B adenosine receptor antagonist counteracts immune-suppressive mechanisms of adenosine and reduces tumor growth in vivo." Cancer Research 82, no. 12_Supplement (2022): 3499. http://dx.doi.org/10.1158/1538-7445.am2022-3499.

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Abstract Under physiological conditions, the extracellular concentrations of adenosine are low, however, levels dramatically increase under metabolically stressful conditions, including inflammation and cancer. The regulatory functions of adenosine are mediated through four members of the adenosine receptor family: A1, A2A, A2B, and A3. While A2A was considered the major contributor to adenosine-mediated suppression of T cell, natural killer cell, and myeloid cell functions, A2B has also recently emerged as a potential modulator of these processes. Both A2A and A2B signal through the same Gs-m
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Xaus, Jordi, Maribel Mirabet, Jorge Lloberas та ін. "IFN-γ Up-Regulates the A2B Adenosine Receptor Expression in Macrophages: A Mechanism of Macrophage Deactivation". Journal of Immunology 162, № 6 (1999): 3607–14. http://dx.doi.org/10.4049/jimmunol.162.6.3607.

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Abstract Adenosine is a potent endogenous anti-inflammatory agent released by cells in metabolically unfavorable conditions, such as hypoxia or ischemia. Adenosine modulates different functional activities in macrophages. Some of these activities are believed to be induced through the uptake of adenosine into the macrophages, while others are due to the interaction with specific cell surface receptors. In murine bone marrow-derived macrophages, the use of different radioligands for adenosine receptors suggests the presence of A2B and A3 adenosine receptor subtypes. The presence of A2B receptor
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Shi, Yanrong, Xiaoguang Liu, Debebe Gebremedhin, John R. Falck, David R. Harder, and Raymond C. Koehler. "Interaction of Mechanisms Involving Epoxyeicosatrienoic Acids, Adenosine Receptors, and Metabotropic Glutamate Receptors in Neurovascular Coupling in Rat Whisker Barrel Cortex." Journal of Cerebral Blood Flow & Metabolism 28, no. 1 (2007): 111–25. http://dx.doi.org/10.1038/sj.jcbfm.9600511.

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Adenosine, astrocyte metabotropic glutamate receptors (mGluRs), and epoxyeicosatrienoic acids (EETs) have been implicated in neurovascular coupling. Although A2A and A2B receptors mediate cerebral vasodilation to adenosine, the role of each receptor in the cerebral blood flow (CBF) response to neural activation remains to be fully elucidated. In addition, adenosine can amplify astrocyte calcium, which may increase arachidonic acid metabolites such as EETs. The interaction of these pathways was investigated by determining if combined treatment with antagonists exerted an additive inhibitory eff
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Marquardt, D. L., L. L. Walker, and S. Heinemann. "Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells." Journal of Immunology 152, no. 9 (1994): 4508–15. http://dx.doi.org/10.4049/jimmunol.152.9.4508.

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Abstract Adenosine potentiates the stimulated release of mast cell mediators. Pharmacologic studies suggest the presence of two adenosine receptors, one positively coupled to adenylate cyclase and the other coupled to phospholipase C activation. To identify mast cell adenosine receptor subtypes, cDNAs for the A1 and A2a adenosine receptors were obtained by screening a mouse brain cDNA library with the use of PCR-derived probes. Mouse bone marrow-derived mast cell cDNA libraries were constructed and screened with the use of A1 and A2a cDNA probes, which revealed the presence of A2a, but not A1,
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Dubey, Raghvendra K., Delbert G. Gillespie, and Edwin K. Jackson. "A2B Adenosine Receptors Mediate the Anti-Mitogenic Effects of Adenosine in Cardiac Fibroblasts." Hypertension 36, suppl_1 (2000): 708. http://dx.doi.org/10.1161/hyp.36.suppl_1.708-b.

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P85 Adenosine inhibits growth of CFs; however, the adenosine receptor subtype that mediates this anti-mitogenic effect remains undefined. Using specific ADE receptor antagonists and agonists and antisense oligonucleotides (OLIGO) against A2B receptors, we investigated the role of A2B receptors in inhibiting cardiac fibroblast growth. PDGF (25ng/ml)-induced DNA synthesis, cell number and collagen synthesis in CFs were inhibited by A2 (chloroadenosine [Cl-Ad]and MECA), but not by A1 (CPA), A2a ( CGS21680 ) or A3 (AB-MECA),receptor agonists.The inhibitory effects of 1μM MECA and Cl-Ad were revers
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Zhan, Enbo, Victoria J. McIntosh, and Robert D. Lasley. "Adenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 3 (2011): H1183—H1189. http://dx.doi.org/10.1152/ajpheart.00264.2011.

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All four adenosine receptor subtypes have been shown to play a role in cardioprotection, and there is evidence that all four subtypes may be expressed in cardiomyocytes. There is also increasing evidence that optimal adenosine cardioprotection requires the activation of more than one receptor subtype. The purpose of this study was to determine whether adenosine A2A and/or A2B receptors modulate adenosine A1 receptor-mediated cardioprotection. Isolated perfused hearts of wild-type (WT), A2A knockout (KO), and A2BKO mice, perfused at constant pressure and constant heart rate, underwent 30 min of
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Lu, Qing, Elizabeth O. Harrington, Julie Newton, et al. "Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement." American Journal of Physiology-Lung Cellular and Molecular Physiology 298, no. 6 (2010): L755—L767. http://dx.doi.org/10.1152/ajplung.00330.2009.

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We have previously demonstrated that adenosine plus homocysteine enhanced endothelial basal barrier function and protected against agonist-induced barrier dysfunction in vitro through attenuation of RhoA activation by inhibition of isoprenylcysteine-O-carboxyl methyltransferase. In the current study, we tested the effect of elevated adenosine on pulmonary endothelial barrier function in vitro and in vivo. We noted that adenosine alone dose dependently enhanced endothelial barrier function. While adenosine receptor A1 or A3 antagonists were ineffective, an adenosine transporter inhibitor, NBTI,
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Tesis sobre el tema "Adenosine A2B receptor"

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BARALDI, Stefania. "Design and Synthesis of New A2B Adenosine Receptor Antagonists." Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2388704.

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Starting from chemical structure of N-benzo-[1,3]dioxol-5-yl-2-[5-(2,6dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol3-yloxy]-acetamide, MRE2029F20* various structural modifications were realized to afford a new series of A2B antagonists. The bioisosteric replacement of the anilide moiety with benzimidazole or quinazoline rings, the effect of the substitution of pyrazole with isoxazole moiety were investigated. Amide bond has been also replaced with the 5phenyl-1,2,4-oxadiazole nucleus on the basis of other adenosine pharmacophores reported previously. In this con
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Sun, Fengqiang. "Physical and functional interaction of A2B adenosine receptor with alpha-actinin-1/." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202009%20SUN.

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Johnston-Cox, Hillary A. "Control of vascular disease and glucose and insulin homeostasis by the A2b adenosine receptor." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12433.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Cardiovascular disease remains a leading cause of mortality. Risk factors, including poor glycemic control, central obesity and dyslipidemia contribute to prothrombotic and proinflammatory states, which elevate
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Afzal, Aqeela. "Reduction in pre-retinal neovascularization by ribozymes that cleave the A2B receptor mRNA." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000624.

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Carroll, Shannon H. "The role of the A2B adenosine receptor in the differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: implications for bone development and fracture repair." Thesis, Boston University, 2013. https://hdl.handle.net/2144/10953.

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Thesis (Ph.D.)--Boston University<br>The development, maintenance and repair of the skeletal system are dependent on the differentiation of both chondrocytes and osteoblasts from their common progenitor, the mesenchymal stem cell (MSC). The A2B adenosine receptor (A2BAR) is a G-protein-coupled receptor that signals by increasing cAMP and/or activating phospholipase C signaling. Considering the published roles of cAMP on MSC differentiation, and our finding that the expression of the A2BAR is induced following injury, we hypothesized that ablation or activation of the A2BAR impacts the differen
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FANG, YING. "SIGNALING PATHWAY FROM THE A2B ADENOSINE RECEPTOR TO EXTRACELLULAR SIGNAL REGULATED KINASES (ERK1/2) IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC) AND ITS ROLE IN HUVEC PROLIFERATION." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1148392082.

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Sorrentino, Claudia. "Role of CD73 - A2A/A2B receptors axis in cancer." Doctoral thesis, Universita degli studi di Salerno, 2018. http://hdl.handle.net/10556/3116.

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2016 - 2017<br>The adenosinergic pathway plays a critical role in cancer development and progression, as well as in drug resistance to chemotherapy and/or targeted-therapy. The goal of this PhD thesis was to investigate and fully characterize the role of CD73/adenosine A2A-A2B receptors axis in cancer, highlighting the therapeutic potential of inhibitors of the adenosinergic pathway. We firstly characterized the mechanism/s by which A2BR promotes immunosuppression and angiogenesis in tumor-bearing hosts, focusing on the role of myeloid-derived suppressor cells (MDSCs) and cancer-associa
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Matsumoto, João Paulo de Pontes. "Efeito modulatório da nicotina sobre o receptor de adenosina A2a em cultura de células do bulbo de ratos geneticamente hipertensos e normotensos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-19022009-104148/.

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A hipertensão arterial é um problema de saúde pública no Brasil, pois aproximadamente 20 % da população adulta desenvolve hipertensão essencial, cujas causas ainda não são conhecidas. No entanto, sua gênese pode estar relacionada com disfunção nas áreas do sistema nervoso central (SNC) que regulam o sistema cardiovascular. O núcleo do trato solitário (NTS) e o bulbo ventrolateral são áreas importantes no controle neural da pressão arterial. Os receptores de adenosina A2a (rA2a) são encontrados em todo o SNC e estão relacionados com estudos terapêuticos de diversas doenças. No NTS a estimulação
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Gandía, Sánchez Jorge. "Oligomerización del receptor A2A de adenosina: interpretando el receptorsoma." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/134352.

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Los receptores acoplados a proteína G (GPCR) conforman la familia de receptores de membrana más grande. El numeroso y variado tipo de señales que detectan han otorgado a estos receptores un alto interés farmacológico. Además, las interacciones entre diferentes tipos de GPCR formando complejos oligoméricos dan lugar a complejos con características bioquímicas diferenciadas de los protómeros que los forman. En esta Tesis Doctoral se han estudiado diferentes aspectos derivados este tipo de interacciones, centrando estos experimentos alrededor del receptor A2A de adenosina (A2AR), un importante ne
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Larner, Carrie Jayne Byrom. "Selective targeting of the adenosine A2A receptor." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608592.

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Libros sobre el tema "Adenosine A2B receptor"

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Chen, Jiang-Fan, and Akihisa Mori. Adenosine A2A Receptor Antagonists. Elsevier Science & Technology Books, 2023.

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Adenosine A2A Receptor Antagonists. Elsevier Science & Technology, 2023.

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Capítulos de libros sobre el tema "Adenosine A2B receptor"

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Kalla, Rao V., Jeff Zablocki, Mojgan Aghazadeh Tabrizi, and Pier Giovanni Baraldi. "Recent Developments in A2B Adenosine Receptor Ligands." In Adenosine Receptors in Health and Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-89615-9_4.

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Ghasemi, Fahimeh, Alireza Mehri, Jorge Peña-García, et al. "Improving Activity Prediction of Adenosine A2B Receptor Antagonists by Nonlinear Models." In Bioinformatics and Biomedical Engineering. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16480-9_61.

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Müller, Christa E., Younis Baqi, Sonja Hinz, and Vigneshwaran Namasivayam. "Medicinal Chemistry of A2B Adenosine Receptors." In The Adenosine Receptors. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-90808-3_6.

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Scherrmann, Jean-Michel, Kim Wolff, Christine A. Franco, et al. "Adenosine A2A Receptors." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1103.

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Ferré, Sergi, César Quiroz, Marco Orrú, et al. "Role of Striatal A2A Receptor Subpopulations in Neurological Disorders." In Adenosine. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3903-5_9.

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Baraldi, Stefania, Pier Giovanni Baraldi, Paola Oliva, Kiran S. Toti, Antonella Ciancetta, and Kenneth A. Jacobson. "A2A Adenosine Receptor: Structures, Modeling, and Medicinal Chemistry." In The Adenosine Receptors. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-90808-3_5.

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Shook, Brian C. "Adenosine A2A Receptor Antagonists." In Topics in Medicinal Chemistry. Springer International Publishing, 2014. http://dx.doi.org/10.1007/7355_2014_67.

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Pinna, Annalisa, Nicola Simola, Lucia Frau, and Micaela Morelli. "Symptomatic and Neuroprotective Effects of A2A Receptor Antagonists in Parkinson’s Disease." In Adenosine. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3903-5_18.

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Morelli, Micaela, Anna R. Carta, and Peter Jenner. "Adenosine A2A Receptors and Parkinson’s Disease." In Adenosine Receptors in Health and Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-89615-9_18.

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Cristalli, Gloria, Christa E. Müller, and Rosaria Volpini. "Recent Developments in Adenosine A2A Receptor Ligands." In Adenosine Receptors in Health and Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-89615-9_3.

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Actas de conferencias sobre el tema "Adenosine A2B receptor"

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Karmouty-Quintana, Harry, James D. West, Anna Hemnes, et al. "The Adenosine A2B Receptor Modulates Pulmonary Hypertension Associated With Chronic Lung Disease." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3391.

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Gałęzowski, Michał, Katarzyna Dziedzic, Paulina Węgrzyn, et al. "Abstract 5555:In vivoandin vitrocharacterization of RVU330 best-in-class dual A2A/A2B adenosine receptor antagonist." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5555.

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Jang, Sunyoung, Seunah Jun, Hosun Lee, et al. "Abstract 1704: Discovery and characterization of a novel triple A1/A2a/A2b adenosine receptor antagonist for cancer immunotherapy." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1704.

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Zhang, Hui, Michael R. Blackburn, Daniel J. Schneider, et al. "Adenosine Activation Of A2B Receptor(s) Is Essential For Stimulated Epithelial Ciliary Motility And Clearance." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1229.

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Barletta, Kathryn E., R. E. Cagnina, Marie D. Burdick, et al. "Absence Of The Adenosine A2B Receptor Protects Against Klebsiella Pneumonia By Enhancing Neutrophil Bactericidal Activity." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2496.

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Subudhi, Sumit, Gerald S. Falchook, Mohamad A. Salkeni, et al. "759 ADPORT-601 (TT-10–101): first-in-human study of adenosine 2A (A2A) and adenosine 2B (A2B) receptor antagonists in participants with selected advanced solid tumors." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0759.

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Zhong, Hongyan, Luiz Belardinelli, and Dewan Zeng. "The Expression And Function Of Adenosine Receptor Subtypes In Primary Human Pulmonary Arterial Smooth Muscle Cells And Endothelial Cells - Potential Role Of A2B Adenosine Receptor In Pulmonary Hypertension." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3459.

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Owen, Dwight, Lai Wei, Mikhail Dikov, et al. "585 Phase 1 dose escalation trial of the selective A2B adenosine receptor antagonist PBF-1129 in patients with metastatic non-small cell lung cancer (mNSCLC)." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0585.

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Ahmad, Aftab, Shama Ahmad, Stacy M. Miller, et al. "Adenosine A2A Receptor Promotes Growth In Fetal Rat Lung Explants." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6396.

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Lin, Juqiang, Yating Lin, Yiming Huang, et al. "Quantitative FRET measurement of the interaction of A1 adenosine receptors and A2A adenosine receptors in living cell." In Optics in Health Care and Biomedical Optics VIII, edited by Qingming Luo, Xingde Li, Yuguo Tang, and Ying Gu. SPIE, 2018. http://dx.doi.org/10.1117/12.2500692.

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Informes sobre el tema "Adenosine A2B receptor"

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Liou, Gregory I., Saif Ahmad, Mohammad Naime, Nadeem Fatteh, and Sohail Khan. Role of Adenosine Receptor A2A in Traumatic Optic Neuropathies. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada581642.

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Liou, Gregory I., Saif Ahmad, and Ahmed Elsherbini. Role of Adenosine Receptor A2A in Traumatic Optic Neuropathies. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada600384.

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