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Literatura académica sobre el tema "Analgesics/opioids"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 12 de febrero de 2022

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Artículos de revistas sobre el tema "Analgesics/opioids"

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Buck, Marcia L. y Jeffrey L. Blumer. "Opioids and Other Analgesics". Critical Care Clinics 7, n.º 3 (julio de 1991): 615–37. http://dx.doi.org/10.1016/s0749-0704(18)30298-7.

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Pleuvry, Barbara J. "Opioids and other analgesics". Current Opinion in Anaesthesiology 5, n.º 4 (agosto de 1992): 527–28. http://dx.doi.org/10.1097/00001503-199208000-00011.

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&NA;. "Opioids and other analgesics". Current Opinion in Anaesthesiology 5, n.º 4 (agosto de 1992): 604–12. http://dx.doi.org/10.1097/00001503-199208000-00028.

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Sebel, Peter S. "Opioids and other analgesics". Current Opinion in Anaesthesiology 6, n.º 4 (agosto de 1993): 665–67. http://dx.doi.org/10.1097/00001503-199308000-00013.

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&NA;. "Opioids and other analgesics". Current Opinion in Anaesthesiology 6, n.º 4 (agosto de 1993): 748–55. http://dx.doi.org/10.1097/00001503-199308000-00030.

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&NA;. "Opioids and other analgesics". Current Opinion in Anaesthesiology 7, n.º 4 (agosto de 1994): B82–88. http://dx.doi.org/10.1097/00001503-199408000-00020.

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&NA;, &NA;. "Opioids and other analgesics". Current Opinion in Anaesthesiology 8, n.º 4 (agosto de 1995): B112—B119. http://dx.doi.org/10.1097/00001503-199508000-00021.

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&NA;, &NA;. "Opioids and other analgesics". Current Opinion in Anaesthesiology 9, n.º 4 (agosto de 1996): B119—B124. http://dx.doi.org/10.1097/00001503-199608000-00020.

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Matthew, Matthew T. y Patricia W. Nance. "Analgesics: Opioids, Adjuvants and Others". Physical Medicine and Rehabilitation Clinics of North America 10, n.º 2 (mayo de 1999): 255–73. http://dx.doi.org/10.1016/s1047-9651(18)30196-7.

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Oyler, PharmD, Douglas R., Kristy S. Deep, MD y Phillip K. Chang, MD. "Opioid use in the acute setting: A survey of providers at an academic medical center". Journal of Opioid Management 14, n.º 3 (2 de julio de 2018): 203–10. http://dx.doi.org/10.5055/jom.2018.0450.

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Objective: To examine attitudes, beliefs, and influencing factors of inpatient healthcare providers regarding prescription of opioid analgesics.Design: Electronic cross-sectional survey.Setting: Academic medical center.Participants: Physicians, advanced practice providers, and pharmacists from a single academic medical center in the southeast United States.Main Outcome Measures: Respondents completed survey items addressing: (1) their practice demographics, (2) their opinions regarding overall use, safety, and efficacy of opioids compared to other analgesics, (3) specific clinical scenarios, (4) main pressures to prescribe opioids, and (5) confidence/comfort prescribing opioids or nonopioids in select situations.Results: The majority of the sample (n = 363) were physicians (60.4 percent), with 69.4 percent of physicians being attendings. Most respondents believed that opioids were overused at our institution (61.7 percent); nearly half thought opioids had similar efficacy to other analgesics (44.1 percent), and almost all believed opioids were more dangerous than other analgesics (88.1 percent). Many respondents indicated that they would modify a chronic regimen for a high-risk patient, and use of nonopioids in specific scenarios was high. However, this use was often in combination with opioids. Respondents identified patients (64 percent) and staff (43.1 percent) as the most significant sources of pressure to prescribe opioids during an admission; the most common sources of pressure to prescribe opioidson discharge were to facilitate discharge (44.8 percent) and to reduce follow-up requests, calls, or visits (36.3 percent). Resident physicians appear to experience more pressure to prescribe opioids than other providers. Managing pain in patients with substance use disorders and effectively using nonopioid analgesics were the most common educational needs identified by respondents.Conclusion: Most individuals believe opioid analgesics are overused in our specific setting, commonly to satisfy patient requests. In general, providers feel uncomfortable prescribing nonopioid analgesics to patients.

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Tesis sobre el tema "Analgesics/opioids"

1

Arends, Rosalinda Helena Gerardus Petronella. "Pharmacokinetics and pharmacodynamics of opioid analgesics /". Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/7955.

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Everett, Bronwyn L. "The impact of linguistic diversity on postoperative opioid consumption /". View thesis, 2000. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20031118.123321/index.html.

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Thesis (MSc (Hons.)Health) -- University of Western Sydney, Macarthur, 2000.
"March 2000" "A thesis presented to the University of Western Sydney Macarthur in partial fulfilment of the requirements for the Degree of Master of Science (Hons) Health" Bibliography: leaves 90-101.

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Tucker, Adam Paul 1965. "An evaluation of the spinal and supraspinal actions of analgesic drugs". Monash University, Dept. of Anaesthesia, 2002. http://arrow.monash.edu.au/hdl/1959.1/8492.

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Bird, Mark Francis. "Investigating the potential of novel bivalent pharmacophores and tetra-branched opioids to produce analgesics with diminished tolerance and dependence profiles". Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/39639.

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All clinical opioid analgesics target the MOP (Mu Opioid Peptide) receptor. While these drugs provide analgesia, long-term treatment leads to tolerance and dependence. By targeting MOP and another member of the opioid receptor family, such as DOP (Delta Opioid Peptide receptor) or NOP (Nociceptin Orphanin F/Q Opioid Peptide receptor), these adverse effects are attenuated. Furthermore, solely targeting DOP or NOP may produce analgesia without the adverse effects associated with MOP. Three groups of variably mixed ligands have been developed; i) Fentanyl-based DOP and NOP bivalents, ii) peptide based MOP and NOP bivalents iii) tetrabranched NOP and DOP monovalent ligands. The pharmacology of these ligands has been investigated in a range of intracellular signalling assays. All compounds were tested in Chinese hamster ovary (CHO) cells expressing human MOP, NOP, DOP or KOP (Kappa Opioid Peptide receptor) receptors. Initial work with Fentanyl-based DOP bivalents resulted in a loss of functional activity at the MOP receptor. Further Fentanyl-derivatives conjugated with Ro65-6570 displayed partial agonist activity at MOP and full agonist activity at MOP. A second MOP/NOP bivalent pharmacophore, (DeNO), based on the peptides Dermorphin (MOP) and N/OFQ demonstrated full agonist activity at both receptors. A tetrabranched ligand formed from N/OFQ, displayed increased potency at the NOP receptor compared to N/OFQ. DeNO was investigated in human embryo kidney (HEK) cells which co-expressed MOP and NOP. The results of functional assays demonstrated a loss of MOP activity caused by the presence of NOP. Further studies with the opioids, Dermorphin and N/OFQ, and antagonists naloxone (MOP) and UFP-101(NOP), have demonstrated a structural interaction between MOP and NOP in this cell line. The work in this thesis demonstrates how modification of peptide structures was more successful in the development of multitarget ligands. The findings from this thesis provide a significant contribution to theory of receptor heterodimerisation between MOP and NOP, as demonstrated by the loss of potency of MOP agonists in the co-expression system.

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Walldén, Jakob. "The influence of opioids on gastric function : experimental and clinical studies". Doctoral thesis, Örebro universitet, Hälsoakademin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1762.

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Efter operation och anestesi får patienter ofta en negativ påverkan på magsäck och tarmar. Illamående och kräkningar är ett stort problem och många har svårt att komma igång med intag av föda och normal tarmfunktion då magsäcken och tarmarna ”står stilla”. Flera faktorer bidrar- bl.a. smärtan, det kirurgiska traumat och de läkemedel vi ger i samband med anestesin. Av de senare är opioider, d.v.s morfin och morfinliknande läkemedel, starkt bidragande. I detta avhandlings- arbete har opioiders effekter på magsäckens motilitet studerats. Med ett absorptionstest (paracetamolmetoden) studerades hos frivilliga hur opioiden remifentanil påverkar magsäckstömning och om kroppspositionen har betydelse för tömningshastigheten ut i tarmen. Remifentanil fördröjde magsäcks-tömningen och under pågående opioid behandling hade kroppspositionen ingen större betydelse, vilket det däremot hade under kontrollförsöken. Med samma metod jämförde vi hos patienter två anestesimetoder och studerade magsäcks-tömning direkt efter en operation. Ingen skillnad kunde påvisas mellan en opioidbaserad och en opioidfri anestesi, men inom respektive grupp var det en stor variation i magsäckstömning mellan individerna. Med en barostat studerades tonus i övre delen av magsäcken. Hos hälften av de frivilliga orsakade remifentanil en ökning av tonus och hos den andra hälften en minskning av tonus. Vidare undersöktes hos en grupp patienter opioiden fentanyls påverkan på den elektriska aktiviteten i magsäcken. Med en elekroga-strograf (EGG) registrerades de långsamma elektriska vågor som koordinerar muskelrörelserna i magsäcken. Hos hälften av de undersökta påverkades aktiviteten av fentanyl med en sänkt vågfrekvens eller upphörande av vågor, medan aktiviteten var opåverkad hos den övriga hälften. För att finna en förklaring till variationen gjordes genetiska analyser av genen för opioidreceptorn hos de undersökta i barostat och EGG studierna. Variationer i genomet, s.k. polymorfism, var inte associerad till utfallen i studierna. Studierna har visat på att opioider har en uttalad effekt på magsäckens motilitet och att den varierar kraftigt mellan individer. Polymorfism i genen för opioid- receptorn förklarade inte skillnaden mellan individer. Direkt efter operation bidrar sannolikt andra faktorer än anestesimetod till det variabla utfallet i magsäckstömning.
After anesthesia and/or surgical procedures, gastrointestinal motility is commonly impaired. The causes are multifactorial, with surgical trauma, pain and perioperative drugs playing a major role. This thesis explores opioid effects on gastric motility in healthy volunteers and patients undergoing surgery. Gastric emptying was studied by an absorption test (paracetamol method), and in healthy volunteers a remifentanil infusion delayed gastric emptying. Body position altered emptying during the control situations, but not during the remifentanil infusion. Further, two anesthetic methods were compared and no differences were found in immediate postoperative gastric emptying between a remifentanil/propofol based intravenous anesthesia and an opioid free inhalational anesthesia, although the interindividual variability was high. Proximal gastric tone was studied using a gastric barostat. An infusion of remifentanil caused two patterns of reaction regarding gastric tone, with half of the subjects increasing and half decreasing in gastric tone. Gastric myoelectrical activity was evaluated with electrogastrography (EGG), and a bolus dose of fentanyl caused a decrease in frequency of the gastric slow waves or disrupted this activity. However, the activity was unaffected in half of the investigated subjects. Analysis of polymorphisms (A118G and G691C) in the µ-opioid receptor gene was performed to find an explanation for the great interindividual variations seen in the barostat and EGG studies, but no association could be found. These studies have shown that opioids have pronounced effects on gastric motility with variable individual responses that are difficult to predict. Polymorphisms in the µ-opioid receptor gene could not explain the variations. Postoperatively, other factors might contribute more than opioids to the impairment in gastric motility.
ISSN 1652-4063

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6

Mazoyer, Julie. "Sédation temporaire, sédation terminale et usage des opiacés : problèmes éthiques associés au traitement de la douleur en soins palliatifs". Thesis, Toulouse 2, 2016. http://www.theses.fr/2016TOU20116/document.

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Notre recherche concerne les conditions d'acceptabilité de différents moyens de traiter la douleur dans les soins palliatifs, par les professionnels de santé et le grand public. Deux moyens sont étudiés : l’utilisation d’antalgiques, notamment de palier III ; la mise en œuvre d’une sédation. Notre recherche est basée sur la Théorie Fonctionnelle de la cognition de Norman Anderson (1981). Concernant l'étude portant sur l’utilisation des antalgiques : 192 participants ont jugé du degré d'acceptabilité de chacun des 56 scénarios proposés, résultant de la combinaison de quatre facteurs : « concertation du médecin avec l’équipe de soins », « demande de la personne à être soulagée de sa douleur », « niveau de douleur, exprimé grâce à l’échelle numérique de douleur », « décision du médecin en termes de prescription d’antalgique ». Pour l'étude portant sur la sédation : 192 personnes ont jugé du degré d'acceptabilité des 48 scénarios proposés. Ils sont le résultat de la combinaison des quatre facteurs suivants : « demande de la personne », « type de sédation », « espérance de vie », « concertation du médecin avec l’équipe de soins ». Pour l’étude portant sur l’utilisation des antalgiques, notamment de palier III, il ressort que seuls trois des facteurs manipulés ont joué un rôle dans l’acceptabilité de la décision du médecin. Il s’agit par ordre croissant des facteurs « niveau de douleur », « décision du médecin » et « concertation du médecin ». Le facteur le moins influent puisque n’ayant pas eu d’effet significatif est le facteur « demande de la personne ». L’analyse en clusters nous a également permis de discriminer 6 groupes de participants, ayant chacun leur propre politique de jugement. Concernant l’étude sur la sédation, nous retrouvons également que trois des quatre facteurs manipulés ont eu une influence sur le jugement d’acceptabilité. Par ordre croissant, il s’agit des facteurs « demande de la personne », « type de sédation » et « concertation du médecin ». Le facteur « espérance de vie » n’a pas eu d’effet significatif. L’analyse en clusters nous a permis de différencier 4 classes de participants, se regroupant selon leur politique de jugement. L'acceptabilité des différents moyens utilisés pour soulager la douleur en fin de vie est largement influencée par les facteurs intervenant dans les scénarios
Our research concerns the conditions of acceptance of different ways to treat pain in palliative care by health professionals and laypeople. Two ways are studied: the use of analgesic, including strong opioids ; implementation of sedation. Our research is based on the Functional Theory of Cognition by Norman Anderson (1981). On the study on the use of analgesics : 192 participants rated the degree of acceptability of each of the 56 proposed scenarios, resulting from the combination of four factors: « decision-making process », « request of the person to be relieved of his pain », « pain level, expressed through digital pain scale », « decision of the physician in terms of painkiller prescription ». For the study of sedation : 192 people judged the acceptability of the 48 proposed scenarios. They are the result of four factors combination: « request for sedation », « type of sedation », « life expectancy », « decision-making process ». In the study on the use of painkillers, especially strong opioids, it appears that only three of the manipulated factors played a role in the acceptability of the doctor's decision. The result by ascending order of the factors is: « pain level », « decision » and « decision-making process ». The less influential factor, since having no significant effect, is the factor « request ». The analysis in clusters also allowed us to discriminate 6 groups of participants, each with their own political judgment. Regarding the study on sedation, we also find that three of the four manipulated factors had influenced the judgment of acceptability. In ascending order, these factors are « request », « type of sedation » and « decision-making process ». The « life expectancy » factor had no significant effect. The analysis in clusters enabled us to distinguish 4 classes of participants, coming together according to their political judgment. The acceptability of the various means used to relieve pain in later life is largely influenced by the factors involved in the scenarios

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Winter, Lara. "Characterisation of the neurosteroid analgesic alphadolone". Monash University, Dept. of Anaesthesia, 2004. http://arrow.monash.edu.au/hdl/1959.1/9669.

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Williams, P. S. "Studies on neuropeptidase inhibitors as potential analgesics". Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378579.

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Gardner, Janet Rose. "Authenticating & repairing personhood : the experiences of opioid dependent back pain sufferers". Monash University, Dept. of Community Medicine, 2003. http://arrow.monash.edu.au/hdl/1959.1/5574.

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Thorn, Simon Alexander. "Investigations into the peripheral and central actions of analgesics". Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238850.

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Libros sobre el tema "Analgesics/opioids"

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Freye, Enno. Opioid agonists, antagonists and mixed narcotics analgesics: Theoretical background and considerations for practical use. Berlin: Springer, 1987.

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I, Basbaum A. y Besson Jean-Marie R, eds. Towards a new pharmacotherapy of pain: Report of the Dahlem Workshop on Towards a New Pharmacotherapy of Pain: Beyond Morphine, Berlin, 1989, November 12-17. Chichester [England]: Wiley, 1991.

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Opioids in cancer pain. 2^a ed. Oxford: Oxford University Press, 2009.

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Stannard, Catherine F. Opioids in non-cancer pain. Oxford: Oxford University Press, 2007.

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J, Meynadier y Zenz M, eds. Regional opioid analgesia: Physiopharmacological basis, drugs, equipment, and clinical application. Dordrecht: Kluwer Academic Publishers, 1991.

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Stimmel, Barry. Pain and its relief without addiction: Clinical issues in the use of opioids and other analgesics. 2^a ed. New York: Haworth Medical Press, 1996.

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Victor, Levy Joseph, ed. Opioids in medicine: A systematic and comprehensive review on the mode of action and the use of analgesics in different clinical pain states. Dordrecht: Springer, 2008.

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Katz, Nathaniel. Opioid prescribing toolkit. Oxford: Oxford University Press, 2011.

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Opioid prescribing toolkit. Oxford: Oxford University Press, 2009.

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American Society of Health-System Pharmacists., ed. Demystifying opioid conversion calculations: A guide for effective dosing. Bethesda, MD: American Society of Health-System Pharmacists, 2010.

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Capítulos de libros sobre el tema "Analgesics/opioids"

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Marcus, Dawn A. "Analgesics and Opioids". En Chronic Pain, 349–65. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-465-4_19.

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Rachana, R., Tanya Gupta, Saumya Yadav y Manisha Singh. "Opioids Analgesics and Antagonists". En Advances in Neuropharmacology, 465–84. Includes bibliographical references and index.: Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429242717-21.

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Ballantyne, Jane C. "Opioids and Other Analgesics". En Drug Abuse and Addiction in Medical Illness, 241–50. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3375-0_18.

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Schuckit, Marc A. "Opioids and Other Analgesics". En Drug and Alcohol Abuse, 147–73. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4757-3232-0_6.

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Esaki, Roy y Alex Macario. "Analgesics: Opioids for Chronic Pain Management and Surgical Considerations". En Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care, 125–45. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-8948-1_8.

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Maul, Corinna, Helmut Buschmann y Bernd Sundermann. "Opioids: 3.3 Synthetic Opioids". En Analgesics, 159–69. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605614.ch3c.

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Friderichs, Elmar y Helmut Buschmann. "Opioids: 3.4 Opioids with Clinical Relevance". En Analgesics, 171–245. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605614.ch3d.

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Bartholomäus, Johannes. "Opioids: 3.5 Drug Delivery Systems for Opioids". En Analgesics, 247–63. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605614.ch3e.

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Friderichs, Elmar. "Opioids: 3.1 Introduction". En Analgesics, 127–50. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605614.ch3a.

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Sundermann, Bernd y Corinna Maul. "Opioids: 3.2 Opioid Pepties". En Analgesics, 151–58. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527605614.ch3b.

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Informes sobre el tema "Analgesics/opioids"

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Acred, Aleksander, Milena Devineni y Lindsey Blake. Opioid Free Anesthesia to Prevent Post Operative Nausea/Vomiting. University of Tennessee Health Science Center, julio de 2021. http://dx.doi.org/10.21007/con.dnp.2021.0006.

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Purpose The purpose of this study is to compare the incidence of post-operative nausea and vomiting (PONV) in opioid-utilizing and opioid-free general anesthesia. Background PONV is an extremely common, potentially dangerous side effect of general anesthesia. PONV is caused by a collection of anesthetic and surgical interventions. Current practice to prevent PONV is to use 1-2 antiemetics during surgery, identify high risk patients and utilize tracheal intubation over laryngeal airways when indicated. Current research suggests minimizing the use of volatile anesthetics and opioids can reduce the incidence of PONV, but this does not reflect current practice. Methods In this scoping review, the MeSH search terms used to collect data were “anesthesia”, “postoperative nausea and vomiting”, “morbidity”, “retrospective studies”, “anesthesia, general”, “analgesics, opioid”, “pain postoperative”, “pain management” and “anesthesia, intravenous”. The Discovery Search engine, AccessMedicine and UpToDate were the search engines used to research this data. Filters were applied to these searches to ensure all the literature was peer-reviewed, full-text and preferably from academic journals. Results Opioid free anesthesia was found to decrease PONV by 69%. PONV incidence was overwhelming decreased with opioid free anesthesia in every study that was reviewed. Implications The future direction of opioid-free anesthesia and PONV prevention are broad topics to discuss, due to the nature of anesthesia. Administration of TIVA, esmolol and ketamine, as well as the decision to withhold opioids, are solely up to the anesthesia provider’s discretion. Increasing research and education in the importance of opioid-free anesthesia to decrease the incidence of PONV will be necessary to ensure anesthesia providers choose this protocol in their practice.

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