Bibliografías temáticas / Blood Diseases Molecular aspects

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Literatura académica sobre el tema "Blood Diseases Molecular aspects"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 31 de enero de 2023

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Artículos de revistas sobre el tema "Blood Diseases Molecular aspects"

1

Schechter, Alan N. "Hemoglobin research and the origins of molecular medicine." Blood 112, no. 10 (November 15, 2008): 3927–38. http://dx.doi.org/10.1182/blood-2008-04-078188.

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Abstract Much of our understanding of human physiology, and of many aspects of pathology, has its antecedents in laboratory and clinical studies of hemoglobin. Over the last century, knowledge of the genetics, functions, and diseases of the hemoglobin proteins has been refined to the molecular level by analyses of their crystallographic structures and by cloning and sequencing of their genes and surrounding DNA. In the last few decades, research has opened up new paradigms for hemoglobin related to processes such as its role in the transport of nitric oxide and the complex developmental contro
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2

Quinlivan, Mark, and Judith Breuer. "Molecular and therapeutic aspects of varicella–zoster virus infection." Expert Reviews in Molecular Medicine 7, no. 15 (August 10, 2005): 1–24. http://dx.doi.org/10.1017/s146239940500966x.

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Varicella–zoster virus (VZV) is a highly species-specific member of the Herpesviridae family. The virus exhibits multiple cell tropisms, infecting peripheral blood mononuclear cells and skin cells before establishing latency in sensory neurons. Such tropisms are essential both for primary infection, which manifests itself as chickenpox (varicella), and subsequent reactivation to cause herpes zoster (shingles). The highly cell-associated nature of the virus, coupled with its narrow host range, has resulted in the lack of an animal model that mimics its diseases in humans, thereby greatly hinder
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3

Shperling, M. M., N. P. Tolokonskaya, N. V. Fomenko, and Ye V. Romanova. "The clinical aspects of Lyme borreliosis." Bulletin of Siberian Medicine 7 (December 30, 2008): 106–10. http://dx.doi.org/10.20538/1682-0363-2008-0-106-110.

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The diagnosis of Lyme borreliosis is objective difficult. There are tendention of increasing of patients the age of 51 and older. The characteristics of disease, for example fever at acute time is connected to reactivity in acute diseases in general. On time antibodies detection of patients blood with suspicion of the cronical borreliosis is not criteria of proven disease.
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Chen, Qijun, Martha Schlichtherle, and Mats Wahlgren. "Molecular Aspects of Severe Malaria." Clinical Microbiology Reviews 13, no. 3 (July 1, 2000): 439–50. http://dx.doi.org/10.1128/cmr.13.3.439.

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SUMMARY Human infections with Plasmodium falciparum may result in severe forms of malaria. The widespread and rapid development of drug resistance in P. falciparum and the resistance of the disease-transmitting mosquitoes to insecticides make it urgent to understand the molecular background of the pathogenesis of malaria to enable the development of novel approaches to combat the disease. This review focuses on the molecular mechanisms of severe malaria caused by the P. falciparum parasite. The nature of severe malaria and the deleterious effects of parasite-derived toxins and host-induced cyt
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5

Villar, M., J. M. Marimon, J. M. Garcia-Arenzana, A. G. de la Campa, M. J. Ferrandiz, and E. Perez-Trallero. "Epidemiological and molecular aspects of rifampicin-resistant Staphylococcus aureus isolated from wounds, blood and respiratory samples." Journal of Antimicrobial Chemotherapy 66, no. 5 (March 2, 2011): 997–1000. http://dx.doi.org/10.1093/jac/dkr059.

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Vogler, Ingridt Hildegard, Anna Nishiya, Helena Kaminami Morimoto, Edna Maria Vissoci Reiche, André Luiz Bortoliero, Tiemi Matsuo, Ester Cerdeira Sabino, and Adelaide Jose Vaz. "Serological, epidemiological and molecular aspects of hepatitis C virus infection in a population from Londrina, PR, Brazil, 2001-2002." Revista do Instituto de Medicina Tropical de São Paulo 46, no. 6 (December 4, 2004): 303–8. http://dx.doi.org/10.1590/s0036-46652004000600002.

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Serological, epidemiological and molecular aspects of hepatitis C virus (HCV) infection were evaluated in 183 subjects from Londrina, Paraná, Brazil, and adjacent areas. Serum samples which tested anti-HCV positive by microparticle enzyme immunoassay (MEIA) obtained from eight patients with chronic hepatitis C, 48 blood donors, and 127 patients infected with the human immunodeficiency virus (HIV) were submitted to another enzyme immunoassay (ELISA) and to the polymerase chain reaction (PCR). About 78.7% of samples were also reactive by ELISA, with the greater proportion (70.8%) of discordant r
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Riva, Giovanni, Mario Luppi, Patrizia Barozzi, Fabio Forghieri, and Leonardo Potenza. "How I treat HHV8/KSHV-related diseases in posttransplant patients." Blood 120, no. 20 (November 15, 2012): 4150–59. http://dx.doi.org/10.1182/blood-2012-04-421412.

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Abstract Posttransplantation human herpesvirus-8 (HHV8)/Kaposi sarcoma herpesvirus (KSHV) primary infection and/or reactivations are associated with uncommon and sometimes fatal, neoplastic, and non-neoplastic diseases. HHV8-related clinical manifestations notably range from Kaposi sarcoma (KS) to either primary effusion lymphoma or multicentric Castleman disease B-cell malignancies, and from polyclonal HHV8-positive plasmacytic lymphoproliferative disorders to bone marrow failure and peripheral cytopenias, associated or not with hemophagocytic syndromes, and to acute hepatitis syndromes. We r
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Artemenko, Yu S., M. B. Khamoshina, V. A. Ryabova, and Z. V. Zyukina. "Obesity in women: current aspects of reproductive health disorders." Meditsinskiy sovet = Medical Council, no. 5 (April 19, 2022): 32–39. http://dx.doi.org/10.21518/2079-701x-2022-16-5-32-39.

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Obesity and overweight tend to increase in prevalence in the whole world. Obese people have a higher incidence of cardiovascular diseases, stroke, osteoarthritis, diabetes mellitus and reproductive system diseases. This is especially evident in women. Hormonal imbalances is developed among obese women in the hypothalamic-pituitary-ovarian axis, typically there are menstruation disorders, anovulation and female infertility. Adipose tissue is an endocrine organ, with an intricate role in bioactive molecules secrete, in particularly adipokines, which interact differently with a variety of molecul
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Eelen, Guy, Lucas Treps, Xuri Li, and Peter Carmeliet. "Basic and Therapeutic Aspects of Angiogenesis Updated." Circulation Research 127, no. 2 (July 3, 2020): 310–29. http://dx.doi.org/10.1161/circresaha.120.316851.

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All organisms growing beyond the oxygen diffusion limit critically depend on a functional vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for oxygen and nutrient supply. A remarkable organotypic heterogeneity is brought about by tissue-specific differentiated endothelial cells (lining the blood vessels’ lumen) and allows blood vessels to deal with organ-specific demands for homeostasis. On the flip side, when blood vessels go awry, they promote life-threatening diseases characterized by endothelial cells inappropriately adopting an angiogenic state (eg,
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Łój, Magdalena, Magdalena Garncarz, and Michał Jank. "Genomic and genetic aspects of heart failure in dogs — A review." Acta Veterinaria Hungarica 60, no. 1 (March 1, 2012): 17–26. http://dx.doi.org/10.1556/avet.2012.002.

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The most common causes of heart failure in dogs are valvular disease, predominantly endocardiosis, and myocardial disease, predominantly dilated cardiomyopathy. They are related to changes in the expression of several genes in the heart muscle and in peripheral blood nuclear cells which could be considered as prognostic or diagnostic markers of heart disease in dogs. Since many human genetic markers of heart failure have turned out to be useless in dogs, the screening for genomic markers of canine heart failure could give more insight into the molecular pathology of these diseases and aid the
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Tesis sobre el tema "Blood Diseases Molecular aspects"

1

Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies / Tina Bianco-Miotto." Thesis, Adelaide, S.A, 2002. http://hdl.handle.net/2440/21857.

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"May 2002"<br>Includes bibliographical references (leaves 229-251)<br>xv, 251 leaves : ill. (some col.) ; 30 cm.<br>Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2003
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Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies." Adelaide, S.A, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phb578.pdf.

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"May 2002" Includes bibliographical references (leaves 229-251) Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.
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Chopra, M. S. "Some biochemical aspects of blood in rheumatoid arthritis and vascular diseases." Thesis, University of Strathclyde, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381360.

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Jim, Jin-to, and 詹展韜. "Genetics and molecular characterization of degenerative disc disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B35720189.

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Lau, Kin-chong, and 劉健莊. "Microarray-based investigations of genetic diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45894760.

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Chan, Shun-kwan, and 陳信君. "Molecular detection of streptococcus sinensis in blood culture samplesfrom hospitalized patients in Hong Kong: aneight-year retrospective study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632074.

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Lilliecreutz, Caroline. "Blood-and Injection Phobia in Pregnancy : Epidemiological, Biological and Treatment aspects." Doctoral thesis, Linköpings universitet, Hälsouniversitetet, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-59745.

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Introduction: Blood- and injection phobia is an anxiety disorder with a prevalence of approximately 3-5% in the general population. The etiology is often a combination of genetic factors and a conditioning experience. The symptoms of blood- and injection phobia are dizziness, confusion, nausea, epigastria discomfort, anxiety and sometimes panic attacks when receiving injections, seeing blood or having a blood sample taken. Unique for this specific phobia is the high probability of fainting when the phobic situation is encountered if there is no possibility to escape or to avoid the stimuli. Du
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Chan, Cheuk-wing Wilson, and 陳卓榮. "ER stress in the pathogenesis of osteochondrodysplasia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085192.

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Makubalo, Zola. "Mutation screening of candidate genes and the development of polymorphic markers residing on chromosome 19q13.3, the progressive familial heart block I gene search area." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51838.

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Thesis (MSc)--Stellenbosch University, 2000.<br>ENGLISH ABSTRACT: Progressive familial heart block type I (PFHBI) is a cardiac ventricular conduction disorder of unknown cause associated with risk of sudden death, which has been described in several South African families. Clinically, PFHBI is characterised by right bundle branch block on ECG, which may progress to complete heart block, necessitating pacemaker implantation. The disease shows an autosomal dominant pattern of inheritance with evidence of genetic anticipation. Using genetic linkage analysis, the PFHBI-causative gene was map
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Hall, Richard James, and n/a. "Chromosome 18 and autoimmune disease." University of Otago. Department of Biochemistry, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070221.141018.

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The autoimmune diseases embody a diverse range of common human conditions that are caused by a loss of self-tolerance in the host immune system to a specific organ or tissue type. Approximately 5% of the general population are affected by autoimmune diseases which include type 1 diabetes (T1D), rheumatoid arthritis (RA) and Graves disease (GD). The majority of the autoimmune diseases are multifactorial in origin, brought about by a combination of both environmental and genetic factors. Numerous susceptibility loci have been identified for each autoimmune disease and a number of these loci have
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Libros sobre el tema "Blood Diseases Molecular aspects"

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B, Provan Andrew, and Gribben John, eds. Molecular hematology. 2nd ed. Oxford: Blackwell, 2005.

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Andrew, Provan, and Gribben John, eds. Molecular hematology. 3rd ed. Chichester, West Sussex: Wiley-Blackwell, 2010.

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George, Stamatoyannopoulos, ed. The molecular basis of blood diseases. 3rd ed. Philadelphia: W.B. Saunders, 2001.

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service), SpringerLink (Online, ed. Molecular Pathology of Hematolymphoid Diseases. Boston, MA: Springer Science+Business Media, LLC, 2010.

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Crisan, Domnita. Hematopathology: Genomic mechanisms of neoplastic diseases. New York, N.Y: Humana Press, 2010.

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Bahou, Wadie Farid. Genetics for haematologists: The molecular genetic basis of haematological disorders. London: ReMEDICA, 2000.

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Naeim, Faramarz. Hematopathology: Morphology, immunophenotype, cytogenetics and molecular approaches. Amsterdam: Elsevier/Academic Press, 2008.

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Pia, Glas-Greenwalt, ed. Fibrinolysis in disease: Molecular and hemovascular aspects of fibrinolysis. Boca Raton, Fla: CRC Press, 1996.

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Modeling tumor vasculature: Molecular, cellular, and tissue level aspects and implications. New York: Springer, 2012.

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Neil, Granger D., ed. Molecular basis for microcirculatory disorders. Paris: Springer, 2003.

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Capítulos de libros sobre el tema "Blood Diseases Molecular aspects"

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Hamilton, John D. "Cytomegalovirus and Blood Transfusion." In Molecular Aspects of Human Cytomegalovirus Diseases, 150–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-84850-6_9.

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Periquito, João S., Ludger Starke, Carlota M. Santos, Andreia C. Freitas, Nuno Loução, Pablo García Polo, Rita G. Nunes, Thoralf Niendorf, and Andreas Pohlmann. "Analysis Protocols for MRI Mapping of the Blood Oxygenation–Sensitive Parameters T2* and T2 in the Kidney." In Methods in Molecular Biology, 591–610. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_36.

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AbstractRenal hypoxia is generally accepted as a key pathophysiologic event in acute kidney injury of various origins and has also been suggested to play a role in the development of chronic kidney disease. Here we describe step-by-step data analysis protocols for MRI monitoring of renal oxygenation in rodents via the deoxyhemoglobin concentration sensitive MR parameters T2* and T2—a contrast mechanism known as the blood oxygenation level dependent (BOLD) effect.This chapter describes how to use the analysis tools provided by vendors of animal and clinical MR systems, as well as how to develop an analysis software. Aspects covered are: data quality checks, data exclusion, model fitting, fitting algorithm, starting values, effects of multiecho imaging, and result validation.This chapter is based upon work from the PARENCHIMA COST Action, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.
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Levin, Tomer Levin T., and Judith Cukor. "Psychological Aspects of Hematological Neoplasms." In Neoplastic Diseases of the Blood, 1291–306. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64263-5_60.

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Levin, Tomer T. "Psychological Aspects of Hematological Neoplasms." In Neoplastic Diseases of the Blood, 1387–402. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3764-2_62.

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Van Ness, Brian. "Molecular Genetics of Myeloma." In Neoplastic Diseases of the Blood, 601–13. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3764-2_31.

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Reitsma, P. H. "Molecular Basis of Thrombophilia." In Hereditary Diseases and Blood Transfusion, 25–30. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2017-7_3.

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Spector, Logan G., Erin L. Marcotte, Rebecca Kehm, and Jenny N. Poynter. "Epidemiology and Hereditary Aspects of Acute Leukemia." In Neoplastic Diseases of the Blood, 179–95. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64263-5_13.

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Linet, Martha S., Graça M. Dores, Clara J. Kim, Susan S. Devesa, and Lindsay M. Morton. "Epidemiology and Hereditary Aspects of Acute Leukemia." In Neoplastic Diseases of the Blood, 199–212. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3764-2_15.

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Peake, I. R. "The Molecular Biology of Haemophilia." In Hereditary Diseases and Blood Transfusion, 3–9. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2017-7_1.

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Siess, W. "Cellular Activation Mechanisms: The Blood Platelet as a Model." In Molecular Aspects of Inflammation, 49–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76412-7_5.

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Actas de conferencias sobre el tema "Blood Diseases Molecular aspects"

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Antonijević, Marko, Žiko Milanović, Edina Avdović, Dušica Simijonović, and Zoran Marković. "ANOTHER LOOK AT THE BIOLOGICAL ROLES OF A PLANT ALKALOID-BERBERINE." In XXVII savetovanje o biotehnologiji. University of Kragujevac, Faculty of Agronomy, 2022. http://dx.doi.org/10.46793/sbt27.455a.

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For millennia, berberine extracts or berberine itself has been the effective traditional drug with wide application due to its broad spectrum of antibiotic activity. A significant aspect of the berberine’s physiological activity that is often overlooked is the ability to go through the blood-brain barrier and has an impact on different processes and irregularities in the brain such as dementia and Alzheimer’s disease. Potential inhibitory activity towards enzymes for which is believed to be involved in these diseases, in this paper is confirmed by molecular docking simulations. Binding energie
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De Luca, Amalia, Christina M. Warboys, Narges Amini, Pedro Ferreira, Peter Gatehouse, David Firmin, Justin Mason, Spencer Sherwin, and Paul C. Evans. "Image-Based Computational Hemodynamics and Microarray Analysis of the Porcine Aortic Arch Reveals a Correlation Between Shear Stress and Endothelial Cell Apoptosis." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80948.

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Atherosclerosis is a focal disease that occurs predominantly at regions of the arterial tree that are exposed to disturbed blood flow, which generates low, oscillatory wall shear stress (WSS) at the lumen. WSS controls the spatial distribution of lesions by influencing numerous aspects of endothelial cell (EC) physiology, including inflammatory activation and viability. Of particular note, ECs in low shear, lesion-prone regions are characterized by increased apoptosis and turnover rates1 thus providing a potential explanation for the distinct spatial localization of lesion formation. Although
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Hill, F. G. H., C. W. Williams, S. M. Enayat, and P. J. Darbyshire. "ASYMPTOMATIC vWD VARIANT WITH ABSENT RISTOCETIN ACTIVITY BUT PRESERVED BOTROCETIN ACTIVITY AND A DAUGHTER WITH TYPE III (HOMOZYGOUS) vWD." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644109.

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The propositus, female aged 1 year, was investigated because of severe bruising. Bleeding time (BT) was in excess of 20 mins, VIIIC &lt;0.01 u/ml and vWF Ag and ristocetin cofactor absent. Family studies showed:-Multimeric analysis was not possible on the propositus, but was normal in the plasma of all other family members. The father of the propositus, however, had an abnormal multimer pattern on lysed platelets, in that the faint low molecular weight doublet is absent and a dense band in the position of the lower band of the doublet with anodal and cathodal trailing.The maternal grandmother
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Pshenichnaya, N. Yu, I. A. Lizinfeld, G. Yu Zhuravlev, and N. S. Morozova. "CHARACTERISTICS OF INCIDENCE RATE OF COVID-19, ACUTE RESPIRATORY DISEASES, INFLUENZA AND COMMUNITY ACQUIRED PNEUMONIA IN RUSSIA ACCORDING TO CLIMATE, GEOGRAFICAL ASPECTS AND POPULATION DENSITY." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-184.

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Priezzhev, A. V., A. E. Lugovtsov, A. N. Semenov, P. B. Ermolinskiy, Kisung Lee, Sehyun Shin, and S. Yu Nikitin. "Laser-optic methods for revealing molecular and microrheologic mechanisms of interaction of blood components and related impairment of metabolism at cardiovascular diseases." In 2020 International Conference Laser Optics (ICLO). IEEE, 2020. http://dx.doi.org/10.1109/iclo48556.2020.9285722.

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Mahmoud, Ahmed M., Daniel H. Cortes, S. Jamal Mustafa, and Osama M. Mukdadi. "High Frequency Precise Ultrasound Imaging System to Assess Mouse Hearts and Blood Vessels." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192836.

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Genetically modified mice provide a powerful tool for understanding the molecular mechanisms and pathogenesis of human cardiovascular diseases like human atherosclerosis [1]. Numerous mouse strains are available today with phenotypes relevant to human cardiovascular diseases [1,2]. These mouse strains have prompted the development of techniques for assessing the cardiovascular function and morphology of living mice. Recently, several imaging techniques have been emerged as promising non-invasive imaging modalities, such as electron-beam computed tomography, magnetic resonance imaging, positron
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Fedorova, O. A. "TO THE FAUNA OF MIDGES (DIPTERA: SIMULIIDAE) AND BITING MIDGES (DIPTERA: CERATOPOGONIDAE) YAMALO-NENETS AUTONOMOUS DISTRICT." In V International Scientific Conference CONCEPTUAL AND APPLIED ASPECTS OF INVERTEBRATE SCIENTIFIC RESEARCH AND BIOLOGICAL EDUCATION. Tomsk State University Press, 2020. http://dx.doi.org/10.17223/978-5-94621-931-0-2020-40.

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On the territory of the Yamal-Nenets Autonomous District, the study of midges and biting midges was carried out during the exploration of new oil and gas deposits in the second half of the 20th century. Currently, the study of the spread of midges and biting midges is relevant, since they are carriers of a number of infectious and invasive diseases of animals and humans. The fauna of blood-sucking diptera insects of the Yamal-Nenets Autonomous Okrug is represented by 116 species. The faunal list of blood-sucking midges of the region is represented by 24 species, including 1 – Simulium paramors
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Sharma, Sonika, and Banshi D. Gupta. "Fiber Optic SPR based Dopamine Sensor utilizing GNP/SnO2 Nanocomposite Sup-ported Molecular Imprinting." In JSAP-OSA Joint Symposia. Washington, D.C.: Optica Publishing Group, 2017. http://dx.doi.org/10.1364/jsap.2017.6a_a410_6.

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Dopamine (DA) belongs to the catecholamine family of neurotransmitters and is very important for humans. It is produced in adrenal glands and several areas of the brain. Dopamine is formed by decarboxylation of DOPA and is a precursor of two other neurotransmitters adrenaline and noradrenalin. Dopamine is the most abundant of the catecholamine, hence affects many aspects of brain functionality such as movement, emotional response and ability to experience pain and pleasure. Dopamine also affects the cardiovascular and renal systems. Excessive secretion of DA (e.g., due to Huntington’s disease)
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Lyulchenko, A. S. "ANALYSIS OF THE FREQUENCY OF OCCURRENCE OF MOLECULAR GENETIC MARKERS OF PREDISPOSITION TO CARDIOVASCULAR PATHOLOGY IN ATHLETES." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-58-62.

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For decades, cardiovascular diseases have been the leading cause of disability and death worldwide. Among athletes, the risk of cardiovascular disease increases significantly due to extreme physical exertion. Genotyping of the DNA samples of athletes and the control group based on the selected candidate genes for the pathology of the cardiovascular system was carried out. Carriers of unfavorable genotypes that significantly increase the risk of thrombosis were identified in the formed groups: dangerous mutations of blood clotting factors II and V were detected in 3.2 % of gymnasts and 17.1% of
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10

Киреева, Виктория, Viktoriya Kireeva, Г. Лифшиц, G. Lifshic, Н. Кох, N. Koh, Ю. Усольцев, Yu Usolcev, Константин Апарцин, and Konstantin Apartsin. "Advantages of a personalized approach to the prevention and treatment of cardiovascular diseases in the staff of the INC Of the SBRAS." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. Москва: INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec9ed47.

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Purpose of the study. To test the functional associations of polymorphic variants of genes in the regulation of blood pressure and vascular tone in employees of the ISC SB RAS. Materials and methods. The study involved patients, employees of the ISC SB RAS, being under care of the outpatient clinic of the Hospital of the ISC SB RAS. During routine laboratory testing the patients were taken 2 ml of blood for genetic analysis and further molecular genetic study on “Hypertension”, “Endothelial dysfunction”, “Pharmacogenetics”, “Inflammatory response” panels. Results. In the analysis of 12 genes c
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Informes sobre el tema "Blood Diseases Molecular aspects"

1

Shpigel, Nahum, Raul Barletta, Ilan Rosenshine, and Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, January 2004. http://dx.doi.org/10.32747/2004.7696510.bard.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of a severe inflammatory bowel disease (IBD) in ruminants, known as Johne’s disease or paratuberculosis. Johne’s disease is considered to be one of the most serious diseases affecting dairy cattle both in Israel and worldwide. Heavy economic losses are incurred by dairy farmers due to the severe effect of subclinical infection on milk production, fertility, lower disease resistance and early culling. Its influence in the United States alone is staggering, causing an estimated loss of $1.5 billion to the agriculture indu
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2

Eldar, Avigdor, and Donald L. Evans. Streptococcus iniae Infections in Trout and Tilapia: Host-Pathogen Interactions, the Immune Response Toward the Pathogen and Vaccine Formulation. United States Department of Agriculture, December 2000. http://dx.doi.org/10.32747/2000.7575286.bard.

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In Israel and in the U.S., Streptococcus iniae is responsible for considerable losses in various fish species. Poor understanding of its virulence factors and limited know-how-to of vaccine formulation and administration are the main reasons for the limited efficacy of vaccines. Our strategy was that in order to Improve control measures, both aspects should be equally addressed. Our proposal included the following objectives: (i) construction of host-pathogen interaction models; (ii) characterization of virulence factors and immunodominant antigens, with assessment of their relative importance
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3

Chalutz, Edo, Charles Wilson, Samir Droby, Victor Gaba, Clauzell Stevens, Robert Fluhr, and Y. Lu. Induction of Resistance to Postharvest Diseases and Extension of Shelf-Life of Fruits and Vegetables by Ultra-Violet Light. United States Department of Agriculture, February 1994. http://dx.doi.org/10.32747/1994.7568093.bard.

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Following preliminary observations by one of the collaborating scientists on this project and the completion of a 1-year, BARD-supported feasibility study (IS-1908-90F), this 3-year BARD project has been executed. The main objectives of the research were to elucidate biochemical and pathological aspects of UV-induced resistance in fruits and vegetables, to characterize physical and biological variables of induced resistance and delay of ripening, and to explore the application of the treatment as a control practice of postharvest diseases and shelf-life extension of fruits and vegetables. Our
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4

Sessa, Guido, та Gregory Martin. MAP kinase cascades activated by SlMAPKKKε and their involvement in tomato resistance to bacterial pathogens. United States Department of Agriculture, січень 2012. http://dx.doi.org/10.32747/2012.7699834.bard.

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The research problem: Pseudomonas syringae pv. tomato (Pst) and Xanthomonas campestrispv. vesicatoria (Xcv) are the causal agents of tomato bacterial speck and spot diseases, respectively. These pathogens colonize the aerial parts of the plant and cause economically important losses to tomato yield worldwide. Control of speck and spot diseases by cultural practices or chemicals is not effective and genetic sources of resistance are very limited. In previous research supported by BARD, by gene expression profiling we identified signaling components involved in resistance to Xcvstrains. Follow u
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5

Chejanovsky, Nor, and Bruce A. Webb. Potentiation of pest control by insect immunosuppression. United States Department of Agriculture, July 2004. http://dx.doi.org/10.32747/2004.7587236.bard.

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Our original aims were to elucidate the mechanisms through which the immunosuppressive insect virus, the Campoletis sonorensis polydnavirus (CsV) promotes replication of a well-characterized pathogenic virus, the Autographa californica multiple nucleopolyhedrovirus (AcMNPV) in hosts that are mildly or non-permissive to virus replication. According to the BARD panels criticism we modified our short-term goals (see below). Thus, in this feasibility study (one-year funding) we aimed to show that: 1. S. littoralis larvae mount an immune response against a baculovirus infection. 2. Immunosuppressio
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Gottlieb, Yuval, Bradley Mullens, and Richard Stouthamer. investigation of the role of bacterial symbionts in regulating the biology and vector competence of Culicoides vectors of animal viruses. United States Department of Agriculture, June 2015. http://dx.doi.org/10.32747/2015.7699865.bard.

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Symbiotic bacteria have been shown to influence host reproduction and defense against biotic and abiotic stressors, and this relates to possible development of a symbiont-based control strategy. This project was based on the hypothesis that symbionts have a significant impact on Culicoides fitness and vector competence for animal viruses. The original objectives in our proposal were: 1. Molecular identification and localization of the newly-discovered symbiotic bacteria within C. imicola and C. schultzei in Israel and C. sonorensis in California. 2. Determination of the prevalence of symbiotic
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