Bibliografías temáticas / Cartilage cells. Osteoarthritis. Cartilage Cell differentiation

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Literatura académica sobre el tema "Cartilage cells. Osteoarthritis. Cartilage Cell differentiation"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 3 de febrero de 2022

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Artículos de revistas sobre el tema "Cartilage cells. Osteoarthritis. Cartilage Cell differentiation"

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Cui, Dixin, Hongyu Li, Xin Xu, et al. "Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis." Stem Cells International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/5979741.

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Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues. In recent years, stem cell-based therapy has raised much attention as an alternative approach towards tissue repair and regeneration. Mesenchymal stem cells (MSCs), derived from the bone marrow, s
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Yang, Xiao, Lin Chen, Xiaoling Xu, Cuiling Li, Cuifen Huang та Chu-Xia Deng. "TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage". Journal of Cell Biology 153, № 1 (2001): 35–46. http://dx.doi.org/10.1083/jcb.153.1.35.

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Endochondral ossification begins from the condensation and differentiation of mesenchymal cells into cartilage. The cartilage then goes through a program of cell proliferation, hypertrophic differentiation, calcification, apoptosis, and eventually is replaced by bone. Unlike most cartilage, articular cartilage is arrested before terminal hypertrophic differentiation. In this study, we showed that TGF-β/Smad3 signals inhibit terminal hypertrophic differentiation of chondrocyte and are essential for maintaining articular cartilage. Mutant mice homozygous for a targeted disruption of Smad3 exon 8
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Wang, Qian, Na Yang, Kun Zhang, Zhong Li, Yangjun Zhu, and Zhe Song. "Effect of intra-articular injection of adipose stem cells on traumatic osteoarthritis cartilage defects." Materials Express 11, no. 1 (2021): 28–37. http://dx.doi.org/10.1166/mex.2021.1874.

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Traumatic osteoarthritis with cartilage defects can lead to mobility problems. Mitotic activity in cartilage is extremely low, and once damaged, repairing can be difficult. The commonly used autologous or allogeneic cartilage transplantation techniques also have certain limitations. In recent years, directed induction of osteoblastic differentiation using adipocytes has been shown to be effective in repairing cartilage defects. However, it is often induced in vitro and is prone to incomplete or over-differentiation. In addition, because of the large differences in the in vivo and in vitro micr
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Huh, Jeong-Eun, Yeon-Cheol Park, Byung-Kwan Seo, et al. "Cartilage Protective and Chondrogenic Capacity of WIN-34B, a New Herbal Agent, in the Collagenase-Induced Osteoarthritis Rabbit Model and in Progenitor Cells from Subchondral Bone." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/527561.

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We sought to determine the cartilage repair capacity of WIN-34B in the collagenase-induced osteoarthritis rabbit model and in progenitor cells from subchondral bone. The cartilage protective effect of WIN-34B was measured by clinical and histological scores, cartilage area, and proteoglycan and collagen contents in the collagenase-induced osteoarthritis rabbit model. The efficacy of chondrogenic differentiation of WIN-34B was assessed by expression of CD105, CD73, type II collagen, and aggrecanin vivoand was analyzed by the surface markers of progenitor cells, the mRNA levels of chondrogenic m
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Shi, Jie, Jiulong Liang, Bingyu Guo, et al. "Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes." Stem Cells International 2017 (2017): 1–17. http://dx.doi.org/10.1155/2017/1709582.

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Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity. Stem cell-based tissue engineering provides a promising treatment option for injured articular cartilage because of the cells potential for multiple differentiations. However, its application has been largely limited by stem cell type, number, source, proliferation, and differentiation. We hypothesized that (1) adipose-derived stem cells are ideal seed cells for articular cartilage rep
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Suchorska, Wiktoria Maria, Ewelina Augustyniak, Magdalena Richter, et al. "Modified methods for efficiently differentiating human embryonic stem cells into chondrocyte-like cells." Postępy Higieny i Medycyny Doświadczalnej 71, no. 1 (2017): 0. http://dx.doi.org/10.5604/01.3001.0010.3831.

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Human articular cartilage has a poor regenerative capacity. This often results in the serious joint disease- osteoarthritis (OA) that is characterized by cartilage degradation. An inability to self-repair provided extensive studies on AC regeneration. The cell-based cartilage tissue engineering is a promising approach for cartilage regeneration. So far, numerous cell types have been reported to show chondrogenic potential, among others human embryonic stem cells (hESCs).
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Dubey, Navneet Kumar, Viraj Krishna Mishra, Rajni Dubey, et al. "Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review." Stem Cells International 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/5421019.

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Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the d
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Goldring, Mary B. "Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis." Therapeutic Advances in Musculoskeletal Disease 4, no. 4 (2012): 269–85. http://dx.doi.org/10.1177/1759720x12448454.

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Chondrogenesis occurs as a result of mesenchymal cell condensation and chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain as resting cells to form the articular cartilage or undergo proliferation, terminal differentiation to chondrocyte hypertrophy, and apoptosis in a process termed endochondral ossification, whereby the hypertrophic cartilage is replaced by bone. Human adult articular cartilage is a complex tissue of matrix proteins that varies from superficial to deep layers and from loaded to unloaded zones. A major challenge to efforts to repair carti
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Koh, Yong-Gon, Jin-Ah Lee, Hwa-Yong Lee, Hyo-Jeong Kim, and Kyoung-Tak Kang. "Biomechanical Evaluation of the Effect of Mesenchymal Stem Cells on Cartilage Regeneration in Knee Joint Osteoarthritis." Applied Sciences 9, no. 9 (2019): 1868. http://dx.doi.org/10.3390/app9091868.

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Numerous clinical studies have reported cell-based treatments for cartilage regeneration in knee joint osteoarthritis using mesenchymal stem cells (MSCs). However, the post-surgery rehabilitation and weight-bearing times remain unclear. Phenomenological computational models of cartilage regeneration have been only partially successful in predicting experimental results and this may be due to simplistic modeling assumptions and loading conditions of cellular activity. In the present study, we developed a knee joint model of cell and tissue differentiation based on a more mechanistic approach, w
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Uzieliene, Ilona, Daiva Bironaite, Paulius Bernotas, Arkadij Sobolev, and Eiva Bernotiene. "Mechanotransducive Biomimetic Systems for Chondrogenic Differentiation In Vitro." International Journal of Molecular Sciences 22, no. 18 (2021): 9690. http://dx.doi.org/10.3390/ijms22189690.

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Osteoarthritis (OA) is a long-term chronic joint disease characterized by the deterioration of bones and cartilage, which results in rubbing of bones which causes joint stiffness, pain, and restriction of movement. Tissue engineering strategies for repairing damaged and diseased cartilage tissue have been widely studied with various types of stem cells, chondrocytes, and extracellular matrices being on the lead of new discoveries. The application of natural or synthetic compound-based scaffolds for the improvement of chondrogenic differentiation efficiency and cartilage tissue engineering is o
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Tesis sobre el tema "Cartilage cells. Osteoarthritis. Cartilage Cell differentiation"

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Yagi, Rieko. "Bcl-2 Regulates Chondrocyte Phenotype Through MEK-ERK1/2 Pathway; Relevance to Osteoarthritis and Cartilage Biology." [Kent, Ohio] : Kent State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1118329494.

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Thesis (Ph.D.)--Kent State University, 2005.<br>Title from PDF t.p. (viewed Sept. 5, 2006). Advisor: Walter E. Horton. Keywords: chondrocytes; osteoarthritis; Sox9; Bcl-2; MEK-ERK 1/2. Includes bibliographical references (p. 91-106).
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Neybecker, Paul. "Caractérisation et étude des potentialités chondrogéniques des cellules souches mésenchymateuses d’origine synoviale pour le traitement des lésions focales et diffuses du cartilage." Thesis, Université de Lorraine, 2019. http://www.theses.fr/2019LORR0122.

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Le cartilage articulaire est un tissu avasculaire et non innervé, ce qui lui confère des capacités de réparation très limitées. Les traitements chirurgicaux actuels ne permettent pas d’obtenir un tissu de réparation similaire au cartilage natif. Les recherches s’orientent depuis de nombreuses années vers l’ingénierie cellulaire et tissulaire du cartilage selon le type de lésions à traiter, focale ou diffuse. Les cellules souches mésenchymateuses (CSMs) constituent une source cellulaire intéressante pour l’ingénierie du cartilage. Elles sont facilement accessibles et ont des potentialités de di
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Bertoni, Lélia. "Évaluation du potentiel thérapeutique des cellules souches mésenchymateuses dans un modèle d'arthropathie expérimentale induite chez le cheval Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1 Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization Evaluation of allogeneic bone-marrow-derived and umbilical cord blood-derived mesenchymal stem cells to prevent the development of osteoarthritis in an equine model Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC417.

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’arthropathie dégénérative est une maladie ayant des répercussions socio-économiques majeures chez l’homme et le cheval. Il n’existe pour l’heure aucun traitement curatif de cette maladie, le cartilage articulaire étant dépourvu de pouvoir de cicatrisation spontané. De nombreux espoirs reposent sur l’utilisation de cellules souches mésenchymateuses (CSM), pour leur potentiel pro-régénératif et anti-inflammatoire. Le premier objectif de cette étude était d’évaluer la tolérance des CSM de sang de cordon ombilical (SCO) et de moelle osseuse (MO) dans des articulations saines. L’étude contrôlée en
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Yu, Yin. "Identification and characterization of cartilage progenitor cells by single cell sorting and cloning." Thesis, University of Iowa, 2012. https://ir.uiowa.edu/etd/3414.

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Cartilage lesion is a fairly common problem in orthopaedic practise. It is often a consequence of traumas, inflammatory conditions, and biomechanics alterations. However, as an avascular and aneural tissue, articular cartilage has minimal healing ability. Over the past decades, surgeons and scientists have proposed a nubmer of treatment strategies to promote restoration of articular cartilage, like arthroscopic lavage, microfracture surgery, osteochoncral autografts and allografts, autologous chondrocyte implantation, and other cell-based repairs. Nevertheless, these solutions often result in
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Mouw, Janna Kay. "Mechanoregulation of chondrocytes and chondroprogenitors the role of TGF-BETA and SMAD signaling /." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11232005-103041/.

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Thesis (Ph. D.)--Bioengineering, Georgia Institute of Technology, 2006.<br>Harish Radhakrishna, Committee Member ; Christopher Jacobs, Committee Member ; Andres Garcia, Committee Member ; Marc E. Levenston, Committee Chair ; Barbara Boyan, Committee Member.
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Tan, Zhijia, and 谭志佳. "Molecular analyses of chondrocyte differentiation and adaptation to ER stress." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/209435.

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Endochondral bone development depends on the progression of chondrocyte proliferation, hypertrophy and terminal differentiation, which requires precise transcriptional regulation and signaling coordination. Disturbance of this process would disrupt chondrocyte differentiation and lead to chondrodysplasias. In cells, a highly conserved mechanism, ER stress signaling, has been developed to sense the protein load and maintain the cellular homeostasis. In humans, mutations in COL10A1 induce ER stress and result in metaphyseal chondrodysplasia type Schmid (MCDS). Previous analysis of a MCDS mouse m
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Leung, Y. L., and 梁宇亮. "Transcriptional regulators of col10al in chondrocyte differentiation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31244440.

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Nasu, Akira. "Genetically Matched Human iPS Cells Reveal that Propensity for Cartilage and Bone Differentiation Differs with Clones, not Cell Type of Origin." Kyoto University, 2014. http://hdl.handle.net/2433/189661.

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Yang, Liu, and 楊柳. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hdl.handle.net/10722/210320.

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Yang, Liu. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43223758.

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Libros sobre el tema "Cartilage cells. Osteoarthritis. Cartilage Cell differentiation"

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Embryonic stem cell therapy for osteo-degenerative diseases: Methods and protocols. Humana Press, 2011.

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Pitzalis, Costantino, Frances Humby, and Michael P. Seed. Synovial pathology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0052.

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Synovial pathology is seen in a variety of disease states, including rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis, and systemic lupus erythmatosus (SLE). This chapter highlights recent advances that characterize the cellular composition of these tissues according to surface markers and chemokine and cytokine expression, and describes synovial functional status and response to therapeutics. In RA, after initiation, pannus migrates over and under cartilage, and into subchondral bone, in a destructive process. Cartilage-pannus junction (CPJ) is characterized as invasive or
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3

Douglas, Kenneth. Bioprinting. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190943547.001.0001.

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Abstract: This book describes how bioprinting emerged from 3D printing and details the accomplishments and challenges in bioprinting tissues of cartilage, skin, bone, muscle, neuromuscular junctions, liver, heart, lung, and kidney. It explains how scientists are attempting to provide these bioprinted tissues with a blood supply and the ability to carry nerve signals so that the tissues might be used for transplantation into persons with diseased or damaged organs. The book presents all the common terms in the bioprinting field and clarifies their meaning using plain language. Readers will lear
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Capítulos de libros sobre el tema "Cartilage cells. Osteoarthritis. Cartilage Cell differentiation"

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Labusca, Luminita, and Florin Zugun-Eloae. "Stem Cell Therapy for the Treatment of Cartilage Defects and Osteoarthritis." In Stem Cells in Clinical Applications. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40144-7_2.

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Ma, Quanquan, Taoran Tian, Nanxin Liu, Mi Zhou, and Xiaoxiao Cai. "Application of Stem Cells and the Factors Influence Their Differentiation in Cartilage Tissue Engineering." In Stem Cell Biology and Regenerative Medicine. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51617-2_1.

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Martin, Frank, Mario Lehmann, and Ursula Anderer. "Generation of Scaffold Free 3-D Cartilage-Like Microtissues from Human Chondrocytes." In Medical Advancements in Aging and Regenerative Technologies. IGI Global, 2013. http://dx.doi.org/10.4018/978-1-4666-2506-8.ch008.

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Since our society is characterized by an increasing age of its people on the one hand and a high number of persons dealing with sports on the other hand, the number of patients suffering from traumatic defects or osteoarthritis is growing. In combination with the articular cartilage specific limited capacity to regenerate, a need for suitable therapies is obvious. Thereby, cell-based therapies are of major interest. This type of clinical intervention was introduced to patients at the beginning of the 1990s. During the last years, a technological shift from simple cell suspensions to more complex 3D structures was performed. In order to optimize the scaffold free generation of cartilage, such as microtissues from human chondrocytes, the authors examine the influence of a static or spinner flask culture with respect to differentiation and architecture of the engineered microtissues. Additionally, the impact of the soluble factors TGF-ß2 and ascorbic acid on this process are investigated. The results demonstrate a positive impact of TGF-ß2 and ascorbic acid supplementation with respect to general Type II Collagen and proteoglycan expression for both the static and spinner flask culture.
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Zhang, Shipin, Jun Sheng Wong, Fulya Ustunkan, et al. "Stem Cells for Treatment of Articular Cartilage Defects and Osteoarthritis." In Frontiers in Stem Cell and Regenerative Medicine Research. BENTHAM SCIENCE PUBLISHERS, 2016. http://dx.doi.org/10.2174/9781681081830116020012.

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Smaida, Rana, Henri Favreau, Moustafa Naja, et al. "Polycaprolactone Based Biomaterials and Sodium Hyaluronate Nanoreservoirs for Cartilage Regeneration." In Stem Cells and Regenerative Medicine. IOS Press, 2021. http://dx.doi.org/10.3233/bhr210018.

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Obstacles persist in the treatment and prevention of articular cartilage defects. Polycaprolactone (PCL) and poly(vinyl-pyrrolidone) (PVP) biomaterials were obtained by electrospinning and electrospraying to inspect their potential application for cartilage regeneration. Sodium hyaluronate (SH) was then added into nanofibers of PCL and particles of PVP. The aim of incorporating sodium hyaluronate to this polymer is to enhance the capacity of articular cartilage to regenerate. Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) were seeded onto these tissue engineering (TE) products. The cell viability in vitro and the ability of biomaterials to support the chondrogenic differentiation of hBM-MSCs have been assessed. We report here that hBM-MSCs on these biomaterials were not able to regenerate articular cartilage mainly due to unsuitable culture environment.
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Fukase, Naomasa, Ingrid K. Stake, Yoichi Murata, et al. "Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal System." In Muscle Cell and Tissue - Novel Molecular Targets and Current Advances [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97311.

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Aging affects bones, cartilage, muscles, and other connective tissue in the musculoskeletal system, leading to numerous age-related pathologies including osteoporosis, osteoarthritis, and sarcopenia. Understanding healthy aging may therefore open new therapeutic targets, thereby leading to the development of novel approaches to prevent several age-related orthopaedic diseases. It is well recognized that aging-related stem cell depletion and dysfunction leads to reduced regenerative capacity in various musculoskeletal tissues. However, more recent evidence suggests that dysregulated autophagy and cellular senescence might be fundamental mechanisms associated with aging-related musculoskeletal decline. The mammalian/mechanical target of Rapamycin (mTOR) is known to be an essential negative regulator of autophagy, and its inhibition has been demonstrated to promote longevity in numerous species. Besides, several reports demonstrate that selective elimination of senescent cells and their cognate Senescence-Associated Secretory Phenotype (SASP) can mitigate musculoskeletal tissue decline. Therefore, senolytic drugs/agents that can specifically target senescent cells, may offer a novel therapeutic strategy to treat a litany of age-related orthopaedic conditions. This chapter focuses on osteoarthritis and osteoporosis, very common debilitating orthopaedic conditions, and reviews current concepts highlighting new therapeutic strategies, including the mTOR inhibitors, senolytic agents, and mesenchymal stem cell (MSC)-based therapies.
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Pitzalis, Costantino, Frances Humby, and Michael P. Seed. "Synovial pathology." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0052_update_001.

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Synovial pathology is seen in a variety of disease states, including rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis, and systemic lupus erythmatosus (SLE). This chapter highlights recent advances that characterize the cellular composition of these tissues according to surface markers and chemokine and cytokine expression, and describes synovial functional status and response to therapeutics. In RA, after initiation, pannus migrates over and under cartilage, and into subchondral bone, in a destructive process. Cartilage-pannus junction (CPJ) is characterized as invasive or ’quiescent’ or ’indistinct’. Invasive CPJ can comprise macrophages, fibroblast-like synoviocytes (FLS), mast cells, and/or neutrophils. CPJ activity is related to the state of activation of the overlying subintima. Subintimal inflammation can be graded to a variety of degrees (I–IV) according to established criteria and is illustrated. In some RA synovia, cellular aggregates organize into ectopic lymphoid structures (ELS) through the expression of lymphorganogenic signals, to exhibit T- or B-cell zones accompanied by dendritic cells and lymphangiogenesis. ELS synthesize rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACAP), considered to be indicative of aggressive disease. The selective cellular expression of macrophage and dendritic cell chemokines and cytokines such as TNF, GMCSF, TGFβ‎‎, IL-1, IL-6, IL-23, and chemokines can be seen in synovia, to form a regulated and cooperative environment that sustains the cellular organization and pathological function. Important to this process are FLS and CD68+ macrophages. CD68 expression correlates with disease severity and can be useful as a surrogate marker of disease modifying activity of therapeutics, such as anti-TNF and anti-B-cell biologics.
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Douglas, Kenneth. "Introduction." In Bioprinting. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190943547.003.0001.

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Abstract: Bioprinting: To Make Ourselves Anew describes how bioprinting emerged from 3D printing and details the accomplishments and challenges in bioprinting tissues of cartilage, skin, bone, muscle, neuromuscular junctions, liver, heart, lung, and kidney. It explains how scientists are attempting to provide these bioprinted tissues with a blood supply and the ability to carry nerve signals so that the tissues might be used for transplantation into persons with diseased or damaged organs. The book presents all the common terms in the bioprinting field and clarifies their meaning using plain language. The reader will learn about bioink—a bioprinting material containing living cells and supportive biomaterials. Additionally, readers will become at ease with concepts such as fugitive inks (sacrificial inks used to make channels for blood flow), extracellular matrices (the biological environment surrounding cells), decellularization (the process of isolating cells from their native environment), hydrogels (water-based substances that can substitute for the extracellular matrix), rheology (the flow properties of a bioink), bioreactors (containers to provide the environment cells need to thrive and multiply). Further vocabulary that will become familiar includes diffusion (passive movement of oxygen and nutrients from regions of high concentration to regions of low concentration), stem cells (cells with the potential to develop into different bodily cell types), progenitor cells (early descendants of stem cells), gene expression (the process by which proteins develop from instructions in our DNA), and growth factors (substances—often proteins—that stimulate cell growth, proliferation, and differentiation). The book contains an extensive glossary for quick reference.
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Saltzman, W. Mark. "The State-of-the-Art in Tissue Exchange." In Tissue Engineering. Oxford University Press, 2004. http://dx.doi.org/10.1093/oso/9780195141306.003.0005.

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It is an impressive spectacle. Multicellular organisms—from fruitflies to humans—emerge from a single cell through a coordinated sequence of cell division, movement, and specialization. Many of the fundamental mechanisms of animal development are known: differentiated cells arise from less specialized precursor or stem cells, cells organize into functional units by migration and selective adhesion, and cell-secreted growth factors stimulate growth or differentiation in other cells. Despite extensive progress in acquiring basic knowledge, however, therapeutic opportunities for patients with tissue loss due to trauma or disease remain extremely limited. Degeneration within the nervous system can reduce the quality and length of life for individuals with Parkinson’s disease. Inadequate healing can cause various problems, including liver failure after hepatitis infections, as well as chronic pain from venous leg ulcers and severe infections in burn victims. The symphony of development is difficult to conduct in adults. Tissue or whole-organ transplantation is one of the few options currently available for patients with many common ailments including excessive skin loss and artery occlusion. During the past century, many of the obstacles to transplantation were cleared: immunosuppressive drugs and advanced surgical techniques make liver, heart, kidney, blood vessel, and other major organ transplantations a daily reality. But transplantation technology has encountered another severe limitation. The number of patients requiring a transplant far exceeds the available supply of donor tissues. New technology is needed to reduce this deficit. Some advances will come from individuals trained to synthesize basic scientific discoveries (for example, in developmental biology) with modern bioengineering principles. Tissue engineering grew from the challenge presented by tissue shortage. Tissue engineers are working to develop new approaches for encouraging tissue growth and repair; these approaches are founded on basic science of organ development and wound healing. A few pioneering efforts are already being tested in patients; these include engineered skin equivalents for wound repair, transplanted cells that are isolated from the immune system by encapsulation in polymer membranes for treatment of diabetes, and chondrocyte implantation for repair of articular cartilage defects.
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Actas de conferencias sobre el tema "Cartilage cells. Osteoarthritis. Cartilage Cell differentiation"

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Wartella, K. A., and J. S. Wayne. "Effect of Mechanical Stimulation on Mesenchymal Stem Cell Seeded Cartilage Constructs." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19645.

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Articular cartilage is a specialized tissue with a restricted capacity for self-repair. Thus, there is a need for a functional tissue replacement product for cartilage due to the ever-increasing occurrence of cartilage injuries and osteoarthritis. Engineering a cartilage replacement construct entails a combination of source cells, cytokines/growth factors, differentiation factors, and a supportive structure to mimic the native environment [1]. An abundant source of cells, isolated from adult bone marrow, are mesenchymal stem cells (MSCs), which when isolated can be a rich cell source given the
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Carmona-Moran, Carlos A., and Timothy M. Wick. "A Novel Multi-Stimuli Bioreactor for Tissue Engineering Cartilage." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14586.

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The demand for tissue engineered articular cartilage for implantation in patients with osteoarthritis requires the development of stable and robust large scale production systems. This can be accomplished through the use of a bioreactor that applies mechanical loading and regulates nutrient transport to promote cell growth, cell differentiation and tissue production. In the present work we have developed a shear stress and perfusion bioreactor (SSPB) capable of providing multiple stimuli to facilitate large-scale production of tissue engineered cartilage.
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Holmes, Benjamin, Nathan J. Castro, Jian Li, and Lijie Grace Zhang. "Development of a Biomimetic Electrospun Microfibrous Scaffold With Multiwall Carbon Nanotubes for Cartilage Regeneration." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93202.

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Cartilage defects, which are caused by a variety of reasons such as traumatic injuries, osteoarthritis, or osteoporosis, represent common and severe clinical problems. Each year, over 6 million people visit hospitals in the U.S. for various knee, wrist, and ankle problems. As modern medicine advances, new and novel methodologies have been explored and developed in order to solve and improve current medical problems. One of the areas of investigation that has thus far proven to be very promising is tissue engineering [1, 2]. Since cartilage matrix is nanocomposite, the goal of the current work
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4

Vandenberg, Theodore W., Christopher R. Nehme, and Thomas P. James. "Application of Microforming to Create Chondrocyte Home Sites in a Natural Cartilage Matrix." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-36953.

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Articular cartilage degeneration is a central pathological feature of osteoarthritis. Cartilage in the adult does not regenerate in vivo and, as a result, cartilage damage in osteoarthritis is irreversible. With our ever-aging population, osteoarthritis has become a leading cause of disability and unfortunately, no optimal treatments for osteoarthritis are currently available. To address this problem, a research community is focused on the development of both natural and synthetic biodegradable tissue scaffolds. The scaffolds must contain depressions or holes for the purpose of chondrocyte see
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5

Holmes, Benjamin, and Lijie Grace Zhang. "Enhanced Human Bone Marrow Mesenchymal Stem Cell Functions in 3D Bioprinted Biologically Inspired Osteochondral Construct." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-66118.

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Cartilage defects, which are caused by a variety of reasons such as traumatic injuries, osteoarthritis, or osteoporosis, represent common and severe clinical problems. Each year, over 6 million people visit hospitals in the U.S. for various knee, wrist, and ankle problems. As modern medicine advances, new and novel methodologies have been explored and developed in order to solve and improve current medical problems. One of the areas of investigation that has thus far proven to be very promising is tissue engineering. Since cartilage matrix is nanocomposite, the goal of the current work is to u
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6

Abdel-Sayed, Philippe, Arne Vogel, and Dominique P. Pioletti. "Dissipation Can Act as a Mechanobiological Signal in Cartilage Differentiation." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-62268.

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Knee cartilage is a soft tissue having viscoelastic properties. Under cyclic loadings, viscoelastic materials dissipate mechanical loadings through heat generation. In knee cartilage, this heat might not be convected because of the tissue avascularity, resulting thus to a local temperature increase. As cells are sensitive to temperature, these thermo-mechanical phenomena of energy dissipation could influence their metabolism. The goal of this study is to evaluate the effect of thermogenesis on chondrogenic differentiation. First, we focused our work in quantifying the heat generated in cartila
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7

Natoli, Roman M., and Kyriacos A. Athanasiou. "Ameliorating Glycosaminoglycan (GAG) Loss and Cell Death in Articular Cartilage Following Single-Impact Loading." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176542.

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Impact loading of articular cartilage leads to post-traumatic osteoarthritis (OA) through its effects on the cells and extracellular matrix (ECM) of the tissue. Studies have shown the level of impact or injurious compression correlates with increased cell death, degradation of the ECM, and detrimental changes in biomechanical properties [1]. Recently, several bioactive agents, such as P188 and IGF-I, have shown promising results by reducing cell death following injurious compression of cartilage explants [2, 3].
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8

Alegre-Aguarón, Elena, Sonal R. Sampat, Perry J. Hampilos, et al. "Biomarker Identification Under Growth Factor Priming for Cartilage Tissue Engineering." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80374.

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Adult articular cartilage has a poor healing capacity, which has lead to intense research toward development of cell-based therapies for cartilage repair. The destruction of articular cartilage results in osteoarthritis (OA), which affects about 27 million Americans. In order to create functional tissue, it is essential to mimic the native environment by optimizing expansion protocols. Cell passaging and priming with chemical or physical factors are often necessary steps in cell-based strategies for regenerative medicine [1]. The ability to identify biomarkers that can act as predictors of cel
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9

Erickson, Isaac E., Steven C. van Veen, Swarnali Sengupta, Sydney R. Kestle, Jason A. Burdick, and Robert L. Mauck. "Effects of Aging and TGF-Beta 3 on Chondrocyte and Mesenchymal Stem Cell Matrix Formation." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19517.

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Articular cartilage pathology is common in the aged population. Numerous studies have shown that aged chondrocytes (CHs) are inferior to juvenile CHs in their ability to proliferate and produce cartilage-specific extracellular matrix proteins, potentially limiting their use in tissue engineering applications for cartilage restoration [1,2]. Mesenchymal stem cells (MSCs) are an alternative cell type that can be expanded in vitro while maintaining their ability to differentiate into cell types comparable to articular chondrocytes. However, organismal aging also influences human MSC proliferation
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Babalola, Omotunde M., and Lawrence J. Bonassar. "Parametric Finite Element Analysis of Physical Stimuli Resulting From Mechanical Stimulation of Tissue Engineered Cartilage." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192633.

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The avascular nature of cartilage results in its limited inability to repair itself upon injury. As a result numerous approaches are being investigated as potential therapies for repair, including tissue engineering strategies. In addition, due to the low density of chondrocytes and the characteristic de-differentiation of the cells when expanded in monolayer [1], other cell types are being investigated as a source for cartilage repair as well. Mesenchymal stem cells (MSCs), which have been shown to differentiate into cells of several lineages including chondrocytes, osteoblasts and adipocytes
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