Literatura académica sobre el tema "Drug Resistance"

Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros

Elija tipo de fuente:

Consulte las listas temáticas de artículos, libros, tesis, actas de conferencias y otras fuentes académicas sobre el tema "Drug Resistance".

Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.

También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.

Artículos de revistas sobre el tema "Drug Resistance"

1

K, Tiwari. "Drug Resistance: Challenges and Updates." Journal of Natural & Ayurvedic Medicine 3, no. 3 (2019): 1–2. http://dx.doi.org/10.23880/jonam-16000196.

Texto completo
Resumen
Use of antibiotics increased dramatically in last two decades. To cure most of the diseases broad spectrum antibiotics given. Human society and healthcare is going in wrong direction. One way the pharmaceutical companies are making huge money from it. The other way around is the overuse of these antibiotics, by patients knowing or unknowingly, not only making pathogens adapted but also the normal flora organisms becoming pathogens in coming future? Present article highlight the issues and possible solution of the present scenario.
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

T.V., Sowjanya* B. Akhila N. Ahalya T. Sai Ram T. Maneesha V. Pavithra. "Drug Resistance In Various Disorders." International Journal in Pharmaceutical Sciences 2, no. 2 (2024): 558–64. https://doi.org/10.5281/zenodo.10684813.

Texto completo
Resumen
Drug resistance is the ability of microorganisms, such as bacteria, viruses, or parasites, to withstand the effects of drugs that were intended to kill or inhibit their growth. In developed countries, drug resistance is the primary cause of death, the burden of infectious diseases is comparatively greater, and patients with a resistance are less likely to be able to afford secondary line treatments, which typically have more complex regimens than first line drugs. Nowadays, antibiotic resistance is increasing. Some of the common drug resistances like Bacteria, Cancer, Diabetes, Leprosy, and HI
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Singh, Amresh Kumar. "Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience." Journal of Microbiology and Infectious Diseases 03, no. 04 (2013): 169–75. http://dx.doi.org/10.5799/ahinjs.02.2013.04.0103.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Dyary, Hiewa Othman. "Veterinary Anthelmintics and Anthelmintic Drug Resistance." Journal of Zankoy Sulaimani - Part A 18, no. 1 (2015): 191–206. http://dx.doi.org/10.17656/jzs.10463.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Çelik, Cem. "Increasing antimicrobial resistance in nosocomial pathogens; multidrug-resistant extensively drug-resistant and pandrug-resistant Acinetobacter baumannii." Journal of Microbiology and Infectious Diseases 4, no. 1 (2014): 7–12. http://dx.doi.org/10.5799/ahinjs.02.2014.01.0116.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Xiaoping, Zhang, and Yu Xiangmin. "Research Progress on Drug-Resistant Bacteria." International Journal of Sciences Volume 8, no. 2019-06 (2019): 1–5. https://doi.org/10.5281/zenodo.3350755.

Texto completo
Resumen
More and more microorganisms have developed drug resistance with the use of antibiotics, and some microorganisms have multi-drug resistance. Therefore, bacterial resistant antibiotic is a serious problem to treating infectious diseases in recent years all over the world. This paper briefly reviews the research progress of bacterial resistance mechanisms all over the world, and provides theoretical basis for exploring effective prevention measures and rational use antibiotics in clinical.Read Complete Article at ijSciences: V82019052079 AND DOI: http://dx.doi.org/10.18483/ijSci.2079
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Giaccone, Giuseppe, and Herbert M. Pinedo. "Drug Resistance." Oncologist 1, no. 1-2 (1996): 82–87. http://dx.doi.org/10.1634/theoncologist.1-1-82.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Hochhauser, D., and A. L. Harris. "Drug resistance." British Medical Bulletin 47, no. 1 (1991): 178–96. http://dx.doi.org/10.1093/oxfordjournals.bmb.a072454.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Prichard, R. K. "Drug resistance." International Journal for Parasitology 29, no. 1 (1999): 137–38. http://dx.doi.org/10.1016/s0020-7519(98)00191-x.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Texidó, Gemma, and Jürgen Moll. "Drug resistance." Drug Discovery Today: Technologies 11 (March 2014): 1–3. http://dx.doi.org/10.1016/j.ddtec.2014.03.013.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
Más fuentes

Tesis sobre el tema "Drug Resistance"

1

Abate, Getahun. "Drug resistance in mycobacterium tuberculosis /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3833-4/.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Marijani, Theresia. "Modelling drug resistance in malaria." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/4063.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Johnson, Rabia. "Understanding the mechanisms of drug resistance in enhancing rapid molecular detection of drug resistance in Mycobacterium tuberculosis." Thesis, Link to the online version, 2007. http://hdl.handle.net/10019.1/1265.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Tam, Stanton Sui Yin. "Anticancer Drug Combinations to Overcome Drug Resistance in Breast Cancer." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27733.

Texto completo
Resumen
For triple negative breast cancer (TNBC) patients, taxanes are the mainstays of chemotherapy but remain susceptible to resistance. Combination therapy of paclitaxel/docetaxel and tyrosine kinase inhibitors (TKIs) improves overall response rates in TNBC patients. Ixabepilone, mechanistically similar to taxanes, shows efficacy in TNBCs refractory to paclitaxel/docetaxel. Yet, there is a lack of studies on ixabepilone-TKI combinations. The first aim was to investigate the efficacy of these combinations in docetaxel-resistant MDA-MB-231 (TXT) cells and parental non-resistant MDA-MB-231 (231C) cell
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Abrahem, Abrahem F. "Mechanisms of drug resistance in malaria." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0033/MQ50704.pdf.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Scott, F. M. "Drug resistance mechanisms in multiple myeloma." Thesis, University of Edinburgh, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.661665.

Texto completo
Resumen
The aim of this thesis was to investigate expression of putative drug resistance markers in myeloma both by examining clinical material and through the development of a xenograft model. Pgp expression was examined in 57 samples from 37 patients with myeloma. Of 23 samples at presentation and 37 at relapse, 7 and 26 respectively were Pgp positive. A myeloma xenograft model was established to examine the acute effects of cytotoxic drugs on the expression of "classical" drug resistance markers and genes involved in regulation of apoptosis. The untreated xenografts were Pgp negative, expressed low
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Pongtavornpinyo, Wirichada. "Mathematical modelling of antimalarial drug resistance." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428249.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Wildridge, David. "Metabolism and drug resistance in Trypanosomatids." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3622/.

Texto completo
Resumen
The principle aim of this project is the investigation of metabolism and mechanisms of pentamidine resistance in trypanosomatids. An understanding of these mechanisms may allow the development of novel drugs to treat Leishmaniasis and human African trypanosomiasis (HAT), caused by the protozoan parasites Leishmania spp and Trypanosoma brucei. In this study a pentamidine resistance L. mexicana promastigote cell line was generated in vitro. This cell line was 20-fold resistant to pentamidine when compared to the parental wild type cells. Furthermore, these lines were cross resistant to other dia
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Doherty, Catherine Jean. "Drug resistance mechanisms in multiple myeloma." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/22154.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

ROMANO, GABRIELE. "Molecular mechanisms of cancer drug resistance." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/93577.

Texto completo
Resumen
Colorectal cancer (CRC) is one of the most prevalent and incident cancers worldwide and it has become soon an important public health issue. Although surgery represents the principal curative treatment, chemotherapy is one of the most important tools currently available for the treatment of CRC. 5-fluorouracil (5FU) is the chemotherapeutic agent of election for CRC treatment. Two main problems affect the outcome of cancer chemotherapy: the use of poorly specific drugs and, in a high percentage of patients, the lack of response due to drug resistance, seen as a major obstacle to improve the ove
Los estilos APA, Harvard, Vancouver, ISO, etc.
Más fuentes

Libros sobre el tema "Drug Resistance"

1

Hait, William N., ed. Drug Resistance. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-1267-3.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Imperial Cancer Research Fund (Great Britain). Drug resistance. Edited by Stark, George R. (George Robert), 1933- and Calvert H. Published for the Imperial Cancer Research Fund by Oxford University Press, 1986.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

N, Hait William, ed. Drug resistance. Kluwer Academic Publishers, 1996.

Buscar texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Baiocchi, Marta, ed. Cancer Drug Resistance. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2513-2.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Mayers, Douglas L., Jack D. Sobel, Marc Ouellette, Keith S. Kaye, and Dror Marchaim, eds. Antimicrobial Drug Resistance. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-46718-4.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Teicher, Beverly A., ed. Cancer Drug Resistance. Humana Press, 2006. http://dx.doi.org/10.1007/978-1-59745-035-5.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Goldstein, Lori J., and Robert F. Ozols, eds. Anticancer Drug Resistance. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2632-2.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Mayers, Douglas L., Jack D. Sobel, Marc Ouellette, Keith S. Kaye, and Dror Marchaim, eds. Antimicrobial Drug Resistance. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47266-9.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Mayers, Douglas L., ed. Antimicrobial Drug Resistance. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-595-8.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Mayers, Douglas L., ed. Antimicrobial Drug Resistance. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-180-2.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
Más fuentes

Capítulos de libros sobre el tema "Drug Resistance"

1

Saez, S. "Drug Resistance." In Endocrine Therapy of Breast Cancer III. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74504-1_3.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Wang, Bo. "Drug Resistance." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_1739-7.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Tomasetti, Cristian. "Drug Resistance." In A Systems Biology Approach to Blood. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2095-2_15.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Tew, Kenneth D. "Drug Resistance." In Basic Science of Cancer. Current Medicine Group, 2000. http://dx.doi.org/10.1007/978-1-4684-8437-3_10.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Tu, Shi-Ming. "Drug Resistance." In Cancer Treatment and Research. Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-5968-3_15.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Wang, Bo. "Drug Resistance." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-46875-3_1739.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Mounsey, Kate E., Robert J. Harvey, and Bart J. Currie. "Drug Resistance." In Scabies. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-26070-4_27.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Weber, Georg F. "Drug Resistance." In Molecular Therapies of Cancer. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13278-5_16.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Ashraf, Saima, Nabila Bashir, Nadia Rashid, et al. "Introduction to Drugs, Drug Targets and Drug Resistance." In Biochemistry of Drug Resistance. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76320-6_1.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Ford, James M., Jin-Ming Yang, and William N. Hait. "P-Glycoprotein-Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal." In Drug Resistance. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-1267-3_1.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.

Actas de conferencias sobre el tema "Drug Resistance"

1

Sarkpa, Eastgar Garmonee, and Liang Xiao. "Knowledge Graphs for Drug Resistance Data Representation." In 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2024. https://doi.org/10.1109/bibm62325.2024.10822289.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

Pompa, Marcello, Dániel András Drexler, Simona Panunzi, et al. "Modeling the development of drug resistance during chemotherapy treatment." In 2024 IEEE 63rd Conference on Decision and Control (CDC). IEEE, 2024. https://doi.org/10.1109/cdc56724.2024.10886423.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Asnaashari, Tina Ghodsi, and Young Hwan Chang. "Optimal drug treatment for reducing long-term drug resistance." In 2022 IEEE 61st Conference on Decision and Control (CDC). IEEE, 2022. http://dx.doi.org/10.1109/cdc51059.2022.9992804.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Khamenehfar, Avid, Ji Liu, Jia Cai, et al. "Drug Accumulation Into Single Drug-Sensitive and Drug-Resistant Prostate Cancer Cells Conducted on the Single Cell Bioanalyzer." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-36166.

Texto completo
Resumen
Multidrug resistance (MDR) occurs in prostate cancer, and this happens when the cancer cells resist chemotherapeutic drugs by pumping them out of the cells. MDR inhibitors such as cyclosporin A (CsA) can stop the pumping and enhance the drugs accumulated in the cells. The cellular drug accumulation is monitored using a microfluidic chip mounted on a single cell bioanalyzer. This equipment has been developed to measure accumulation of drugs such as doxorubicin (DOX) and fluorescently labeled paclitaxel (PTX) in single prostate cancer cells. The inhibition of drug efflux on the same prostate cel
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Ayati, Marzieh, Golnaz Taheri, Shahriar Arab, Limsoon Wong, and Changiz Eslahchi. "Overcoming drug resistance by co-targeting." In 2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2010. http://dx.doi.org/10.1109/bibm.2010.5706562.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Bumin, Aysegul, Megan Shah, Kejun Huang, and Tamer Kahveci. "Vulture: VULnerabilities in impuTing drUg REsistance." In BCB '23: 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics. ACM, 2023. http://dx.doi.org/10.1145/3584371.3612993.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Shurbeska, Boneva, Jasmina Nikolovska, Vladimir Mitrevski, et al. "Following the resistance pattern of mycobacterium tuberculosis." In Proceedings of the International Congress Public Health - Achievements and Challenges. Institute of Public Health of Serbia "Dr Milan Jovanović Batut", 2024. http://dx.doi.org/10.5937/batutphco24029s.

Texto completo
Resumen
Background: Tuberculosis (TB) accounts for over 40% of all mortality cases from communicable diseases in Europe.Multidrug-resistant TB (MDR-TB) is TB that does not respond to at least isoniazid and rifampicin, the 2 most powerful anti-TB drugs. 30 countries worldwide are classified as high multi drug resistant (MDR) TB burden countries, nine are in the European Region. The emergence of combined resistance to rifampicin and isoniazid (MDR-TB) is a matter of global concern. Methods and Objectives: Over a period of 10 years we examined patient specimens for TB. Culture-positive samples were subje
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Sallum, Ulysses W., Xiang Zheng, Sarika Verma, and Tayyaba Hasan. "Exploiting bacterial drug resistance: a single construct for the diagnosis and treatment of drug resistant infections." In 12th World Congress of the International Photodynamic Association, edited by David H. Kessel. SPIE, 2009. http://dx.doi.org/10.1117/12.828202.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Casagrande, Anne-Sophie, Florence Mahe, Vin Kotraiah, Matt Pando, and Laurent Desire. "Abstract 4860: Identification of novel epitopes, drug resistance markers and drug resistance mechanism using alternative splicing studies." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-4860.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Taitt, Chris Rowe, Tomasz Leski, David Stenger, et al. "Antimicrobial resistance determinant microarray for analysis of multi-drug resistant isolates." In SPIE Defense, Security, and Sensing. SPIE, 2012. http://dx.doi.org/10.1117/12.924569.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.

Informes sobre el tema "Drug Resistance"

1

DeClerck, Yves A. Environment-Mediated Drug Resistance in Neuroblastoma. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada591172.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
2

DeClerck, Yves A. Environment-Mediated Drug Resistance in Neuroblastoma. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada616252.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
3

Perelson, A. S., B. Goldstein, and B. T. Korber. Emerging pathogens: Dynamics, mutation and drug resistance. Office of Scientific and Technical Information (OSTI), 1997. http://dx.doi.org/10.2172/534529.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
4

Hiscott, John. Oncolytic Virotherapy Targeting Lung Cancer Drug Resistance. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada589848.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
5

Kanja, Claire, and Sarah Bunn. Drug Therapies for COVID-19. Parliamentary Office of Science and Technology, 2022. http://dx.doi.org/10.58248/rr80.

Texto completo
Resumen
Research studies involving thousands of people have allowed scientists to test which drugs are effective at treating COVID-19. Several drug therapies are now available to treat people who are in hospital with COVID-19, or to prevent infections in vulnerable people becoming more serious. This briefing explains which drugs are available, the groups of people in which they are used and how they work. It also outlines the importance of monitoring the emergence of new variants and drug resistance.
Los estilos APA, Harvard, Vancouver, ISO, etc.
6

Shen, Youqing, Maciej Radosz, and William J. Murdoch. Breast Cancer-Targeted Nuclear Drug Delivery Overcoming Drug Resistance for Breast Cancer Chemotherapy. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada559246.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
7

Kennedy, Katherine A. Physiological Stree-Induced Drug Resistance and Its Reversal. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada398214.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
8

Kennedy, Katherine A. Physiological Stress-Induced Drug Resistance and Its Reversal. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada408700.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
9

Kennedy, Katherine. Physiological Stress-Induced Drug Resistance and Its Reversal. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada383040.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
10

Kennedy, Katherine. Physiological Stress-Induced Drug Resistance and its Reversal. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada474449.

Texto completo
Los estilos APA, Harvard, Vancouver, ISO, etc.
Ofrecemos descuentos en todos los planes premium para autores cuyas obras están incluidas en selecciones literarias temáticas. ¡Contáctenos para obtener un código promocional único!