Literatura académica sobre el tema "Exposition aux perturbateurs endocriniens"
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Artículos de revistas sobre el tema "Exposition aux perturbateurs endocriniens":
Guzylack-Piriou, L. y G. Bouchaud. "Exposition aux perturbateurs endocriniens et développement des maladies allergiques". Revue Française d'Allergologie 59, n.º 1 (febrero de 2019): 22–31. http://dx.doi.org/10.1016/j.reval.2018.09.003.
Lucon, Marie-Prisca Chaffard, Claire Philippat, Remy Slama, Barbara Heude y Sabine Plancoulaine. "Exposition prénatale aux perturbateurs endocriniens et sommeil de l’enfant à 2 ans". Médecine du Sommeil 17, n.º 1 (marzo de 2020): 58. http://dx.doi.org/10.1016/j.msom.2019.12.069.
Caudeville, Julien. "Exposition aux perturbateurs endocriniens et risque de cancer du sein : une revue systématique". Environnement Risques Santé 21, n.º 1 (febrero de 2022): 80–81. http://dx.doi.org/10.1684/ers.2021.1616.
Mauduit, Claire, Nadjem Lakhdari, Bénazir Siddeek, Lilia Inoubli, Véronique Isnard y Mohamed Benahmed. "Exposition néonatale aux perturbateurs endocriniens estrogéniques : programmation de l’infertilité masculine par des mécanismes épigénétiques". Morphologie 99, n.º 327 (diciembre de 2015): 156–57. http://dx.doi.org/10.1016/j.morpho.2015.09.017.
Mieusset, R. "Anomalies du développement testiculaire : l’hypothèse d’une exposition aux perturbateurs endocriniens doit-elle se limiter à la vie fœtale et aux cellules germinales?" Basic and Clinical Andrology 22, n.º 2 (18 de mayo de 2012): 67–68. http://dx.doi.org/10.1007/s12610-012-0180-5.
Rouillon, Steeve, Claire Grignon, Nicolas Venisse, Cédric Nadeau, Marion Albouy-Llaty, Virginie Migeot, Antoine Dupuis y Bertrand Brunet. "Exposition hydrique au bisphénol A et à ses dérivés chlorés et liens avec le cancer du sein : étude de faisabilité BREDI I (Breast and Endocrine Disrupter Investigation Part 1)". Revue des sciences de l’eau 28, n.º 3 (10 de noviembre de 2015): 215–20. http://dx.doi.org/10.7202/1034010ar.
Geantot, Agnès. "Halte aux perturbateurs endocriniens". Oxymag 30, n.º 155 (julio de 2017): 1. http://dx.doi.org/10.1016/j.oxy.2017.05.003.
Manus, Jean-Marie. "Alerte aux perturbateurs endocriniens multisystèmes". Revue Francophone des Laboratoires 2011, n.º 429 (febrero de 2011): 20. http://dx.doi.org/10.1016/s1773-035x(11)70746-8.
Fini, Jean-Baptiste y Barbara Demeneix. "Les perturbateurs thyroïdiens et leurs conséquences sur le développement cérébral". Biologie Aujourd'hui 213, n.º 1-2 (2019): 17–26. http://dx.doi.org/10.1051/jbio/2019009.
Houdeau, Éric. "Perturbateurs endocriniens, nanoparticules… l’intestin est-il trop perméable aux xénobiotiques ?" Pratiques en nutrition 11, n.º 43 (julio de 2015): 21–24. http://dx.doi.org/10.1016/j.pranut.2015.06.006.
Tesis sobre el tema "Exposition aux perturbateurs endocriniens":
Albouy-Llaty, Marion. "Exposition prénatale hydrique aux perturbateurs endocriniens et issues de grossesse". Thesis, Poitiers, 2014. http://www.theses.fr/2014POIT1401/document.
Drinking-water as a source of exposure to endocrine disruptors, particularly in pregnant women whose water-use habits change during pregnancy, has seldom been studied. Our objectives were i) to study the possible relationship between prenatal exposure to endocrine disruptors in drinking water, socioeconomic factors and prevalence of neonates born small-for-gestational-age (SGA) or preterm birth ; ii) to estimate for the first time in France the water-use habits of pregnant women throughout pregnancy.Three epidemiologic studies from a retrospective cohort were carried out on 13,654 pregnant women who gave birth in Deux-Sèvres (France) between 2005 and 2010. An exposure to moderate dose of nitrates in drinking-water increased SGM risk, particularly for women living in less deprived areas. No relationship between prenatal exposure to 2-hydroxyatrazin in drinking-water and preterm birth risk was found.Water-use habits during pregnancy were assessed with a questionnaire on 132 women from the EDDS prospective cohort. Water ingestion was stable during pregnancy and tap water predominated over bottled water. In order to reconstitute the dose of pollutant intake from water, the results of this estimation by questionnaire will need to be merged with analytical dosages in waters and biological matrices.Our study confirms the interest of an interdisciplinary approach to environmental health and the key importance of education in that field
Gharieb, Katia. "Exposition précoce aux toxiques et déséquilibres nutritionnels : l’inflammation et les lésions précancéreuses de la prostate". Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4125/document.
Non-communicable diseases (NCDs) including cardiovascular diseases, cancers, respiratory diseases and diabetes kill 38 million people worldwide every year, 16 million of them before the age of 70. Until the 1990s, the origin of these pathologies was associated with the lifestyle of the individual: consumption of tobacco, alcohol, physical inactivity and an unbalanced diet. Since the development of the concept of DOHaD, identifying the developmental origins of health and disease, number of evidence showed that NCDs have, in part, an early origin during the peri-conception period (in utero, first years of life). Exposure during this period to food imbalances, toxic chemicals, synthetic chemicals disrupting endogenous hormones (endocrine disruptors, EDCs) may impact the developing body through epigenetic changes imprinted by the environmental factors to which individuals are exposed. However, the phenotypes and mechanisms involved are still far from being decrypted. During this thesis, we focused on developmental effects on the prostate. In fact, prostate cancer (PCa) is the second leading cause of cancer and the fifth leading cause of death by cancer in the world. Data from the literature shows that dietary imbalances (High Fat Diet, HFD) and estrogen-like EDCs are risk factors for this cancer. We developed an experimental model of rats (young adults, 90 days postnatal) exposed during pregnancy until weaning to HFD (60% fat), or estrogen (estradiol benzoate, EB) during the neonatal period, or a combination of both, to explore the effects on the prostate (ventral lobe). Peri-natal exposure to EB or EB + HFD reduces the weight of the adult prostate. This abnormality is associated with low (HFD), moderate (EB) or massive (EB + HFD) prostate inflammation. The infiltrate is composed mainly of macrophages and T lymphocytes. This inflammation is associated with an increase in the prostate of pro-inflammatory cytokine TNFa, CCL2 / MCP1 (EB) but also IL-6 (EB + HFD) as well as a deregulation of the NLRP3 inflammasome. NLRP3 is chronically activated since its substrates IL1b and IL-18 were over expressed. In conclusion, we show that peri-conception exposure to an estrogen or HFD + EB combination programs prostatic lesions in adult animals. In men, it is suggested that chronic inflammatory lesions (proliferative inflammatory atrophy) would, as for other organs, be a first step towards the onset of carcinogenesis. Thus, our experimental model is relevant for the study of the early stages of prostatic tumorigenesis
Nakiwala, Dorothy. "Exposition prénatale aux phénols et aux phtalates, développement neurologique de l'enfant et rôle des hormones thyroïdiennes". Thesis, Université Grenoble Alpes, 2020. http://www.theses.fr/2020GRALS003.
Context: The increase in the prevalence of neurodevelopmental disorders warrants identification of the possible underlying modifiable risk factors. Pregnant women are constantly exposed to several phenols and phthalates that are endocrine disrupting chemicals and have been linked to various adverse neurodevelopmental outcomes in toxicological studies. One of the suggested mechanisms of neurotoxicity of these compounds is by disruption of the thyroid hormone pathway.Aims: 1) To document if the use of personal care products (PCP) could influence phenols biomarkers concentrations during pregnancy; 2) to assess associations between prenatal exposure to phenols and phthalates and child neurodevelopment; and 3) to assess associations between prenatal exposure to phenols and phthalates on the thyroid hormone levels of pregnant women and their newborns.Methods: We relied on three complementary cohorts; the SEPAGES-feasibility study with multiple urine samples and detailed, time-resolved information on PCP use, the EDEN cohort with maternal urinary concentrations of phenols, phthalates and information on child neurodevelopment and the SEPAGES cohort with information on gestational exposure to phenols and phthalates (assessed in 2 pools of 21 urine sample per participant) and levels of thyroid hormones levels during pregnancy and at birth.Results: The total number of PCP applications (without distinction) was positively associated with the parabens’ and bisphenol S urinary concentrations during pregnancy but not with other phenols assessed (benzophenone-3, triclosan and bisphenol A).No phenol or phthalate metabolite pregnancy concentration was negatively associated with IQ of boys at 5 years. Some associations with child behavior were observed at 3 and 5 years: Bisphenol A was positively associated with the relationship problems subscale at 3 years and the hyperactivity–inattention subscale scores at 5 years. Mono-n-butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problems, and emotional symptom scores at 3 years. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 years. After dichotomizing behavioral scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 years.Regarding the associations with maternal hormones, bisphenol A was negatively associated with the Ln (TSH) z-score; MBzP, a metabolite of benzylbutyl phthalate (BBP), was positively associated with the TT4 z-score and triclosan was negatively associated with the TT3/TT4 ratio z-score. When biomarker concentrations were categorized in tertiles, we observed non-monotonic associations between TSH and triclosan (U-shape) and MnBP, a metabolite of di-n-butyl phthalate (DBP) (inverse U-shape). In newborns, only sex-specific effects were observed: bisphenol A was positively associated with the TT4 z-score in male newborns while triclosan was negatively associated with the TT4 z-score in females.Conclusion: Findings in this study concur with previous literature that PCPs use may contribute to exposure to parabens. Our study was the first to report associations between PCP use and bisphenol S, a substitute of bisphenol A. In line with previous studies, bisphenol A and various phthalates, including DBP and BBP exposure during pregnancy, were associated adverse behavioral symptoms among boys. Our study was the first to report adverse neurobehavioral effects in relation to triclosan exposure. The four compounds associated with adverse behavioral effects in EDEN were also associated with one or more thyroid hormone levels of mothers or newborns in the SEPAGES cohort, suggesting possible disruption of thyroid hormones homeostasis
Chamard-Jovenin, Clémence. "Impact d’une surexpression d’ERα36 et/ou d’une exposition aux alkylphénols sur la physiopathologie de la glande mammaire". Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0232/document.
This work was dedicated to study how a variant of estrogen receptor α, ERα36, acts in initiation and progression of breast cancer. In the laboratory, his expression in testicular cancer was shown to stimulate cell proliferation in vitro and in vivo after environmental pollutant exposure. The compounds studied, the alkylphenols, are endocrine disruptors, interfering with normal estrogen signaling. Gene interaction network modelling from retrospective analysis of breast cancer samples showed that ERα36 expression was correlated with the expression of cell migration markers, typical of tumor progression. In vitro ERα36 overexpression and in a unique mouse Knocked In model, expressing ERα36 in the mammary gland, showed that ERα36 is sufficient to alter epithelial phenotype of normal breast cells. Alkylphenols exposure, that stimulated ERα36 endogenous expression, increased cellular alterations and contributed to transgenerational acquisition of properties related to neoplastic transformation. Analysis of this multidisciplinary project were based on biological expertise, mathematics and bioinformatic tools. These results enabled to highlight for the first time the potential role of ERα36 in tumor initiation and confirmed his involvement in breast cancer progression. Finally, we showed that exposure to environmental doses of alkylphenols during the perinatal period can lead to transgenerational modification of mammary gland differentiation under ERα36 control and eventually may increase breast cancer risk
Laborie, Stéphanie. "Exposition humaine aux perturbateurs endocriniens par inhalation : caractérisation de la contamination de l’air intérieur par analyses chimiques et biologiques in vitro". Thesis, Paris, EPHE, 2015. http://www.theses.fr/2015EPHE3059/document.
The objective of this project was to develop a bio-analytical approach leading to the assessment of the inherent hazard of the indoor air multi-contamination. Chromatographic methods combined with mass spectrometry were developed and validated for 62 target molecules known or suspected as endocrine-disrupting (ED) compounds. The ED potential was assessed by cellular bioassays measuring perturbations of transcriptional activity. The data showed that the predominant families of compounds in indoor air were in the following descendant order: phthalates > musks > alkylphenols > parabens. The ED contaminants were mainly present in gaseous phase, and the most contaminated locations were the day nursery and the house. An estrogenic, thyroid and anti-androgenic potential was attributed to indoor air. In agreement with its contamination profile, the biological activity of the latter was concentrated predominantly in the gaseous phase, and tended to be higher in the day nursery and the house. An effect-directed analysis (EDA) was carried out to identify the target chemicals responsible for the ED effects of indoor air. The following chemicals were identified as being potentially responsible for the observed ED effects: phthalates, methyl-paraben, alkylphenols, cypermethrin and synthetic musks. This work provides both knowledge about the inherent hazard of the indoor air multi-contamination and exposure data useful in health risk assessment
Philippat, Claire. "Utilisation des biomarqueurs d'exposition en épidémiologie environnementale : application à l'étude des effets des expositions intra-utérines aux phénols et au phtalates sur la croissance pré-et post-natale". Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENS014/document.
Background: Phthalates and phenols belong to the family of short half-life endocrine disruptors. Data regarding their effects on fetal and early post-natal growth in Human are sparse and suggest a sex-specific effect of some phenols on birth weight. One of the limitations of these studies is exposure assessment usually based on the measurement of their concentrations in a small number of maternal urine samples collected during pregnancy. Because of their low persistence in the organisms and the likely episodic nature of the exposures, urinary concentrations of these chemicals are likely to vary. Chemical concentrations measured in alternative matrix, such as amniotic fluid, might be a relevant dosimeter of fetal exposure.Objectives: Objectives of the thesis were: to study the potential effects of prenatal exposures to phenols and phthalates on pre- and early post-natal growth; to characterize variability in maternal urine concentrations of phenols throughout pregnancy and to compare phenol concentrations in amniotic fluid to those measured in maternal urine collected same day; to characterize the impact of increasing the number of measurements to estimate exposure on bias and statistical power of epidemiological studies.Methods: Associations between phenols, phthalates and growth were studied among a subsample of pregnant women of the French EDEN cohort delivered boys (n =520). We measured fetal growth with ultrasound (three times during pregnancy) and birth measurements. We used standardized measures acquired between birth and 3 years of age to model postnatal growth. We measured biomarkers of phthalates and phenols in maternal urines collected once during pregnancy: 191 women were assessed in 2008 and 410 other women in 2012 (ntot = 601). Variability in phenol urine concentrations and relationship between concentrations measured in amniotic fluid and maternal urine collected on the same day were studied among 71 pregnant women presenting for an amniocentesis at the Mount Sinai Medical Center (NY, USA). Maternal urine was collected at the time of the amniocentesis appointment, and on two subsequent occasions. Urine and amniotic fluid were analyzed for nine phenols.The study aiming at characterizing bias was based on simulated data. Results: Among the subsample of 191 pregnant women from the EDEN cohort, we observed a negative association between dichlorophenols and birth weight and a positive association between benzophenone-3 and birth weight. The associations with dichlorophenols were not replicated in the larger subsample of the EDEN cohort (n = 520). Triclosan concentration was negatively associated with all of the growth parameters measured at the third ultrasound examination (p ≤ 0.16) and with head circumference measured at birth (β = - 1.4 mm, 95% CI; -2.8; 0.0). All of the parabens were positively associated with weight at birth (p < 0.05). These associations remained in childhood for methyl- and propyl-parabens. Regarding the variability in phenol urinary concentrations during pregnancy, the intraclass correlation coefficients (ICC) ranged between 0.48 and 0.62 for all phenols except bisphenol A (ICC = 0.11). Only benzophenone-3 and propylparaben were detectable in at least half of the amniotic fluid samples; for these phenols, concentrations in maternal urine and amniotic fluid were positively associated. In a simulation study, we estimated that 5 samples will be needed to correctly estimate exposure to chemicals with ICC of 0.6, while for chemicals with ICC of 0.15 around 25 samples would be needed.Conclusion: We only had spot urine sample to assess exposure in the EDEN cohort and findings may be affected by exposure misclassification, especially for bisphenol A for which we observed high variability in urine concentrations. Nevertheless, our study lends support to a potential effect of prenatal exposure to some phenols on pre- and early post-natal growth
Coudon, Thomas. "Développement et application de méthodologies d'évaluation des expositions atmosphériques chroniques aux dioxines et au cadmium dans le cadre d'études épidémiologiques". Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1093/document.
A number of studies have examined the link between breast cancer and exposure to air pollution, including dioxins and cadmium. However, the results of these studies are inconclusive and present a number of methodological limitations. The main objective of this thesis was to develop a spatial indicator to assess chronic atmospheric exposure to dioxins and cadmium of women from the E3N cohort in France between 1990 and 2008. We first performed an inventory and created a database of 2620 dioxins and 2700 cadmium emitting sources in France between 1990 and 2008 and estimated and geolocated their annual emissions. The location of the sources and their estimated emissions were used as the basis for the construction of the indicator. Combination of additional spatial parameters, allowed us to obtain a "substantial" agreement between the dioxin and cadmium exposure classifications of the E3N subjects geolocalised at their residential address, using the estimated bythe indicator and exposures estimates derived from the Gaussian model. We also evaluated the spatial-temporal variability of dioxin and cadmium concentrations over nearly two decades in the Lyon metropolitan area, taking into account a wide variety of source types. This is the first study comparing concentrations predicted by a dispersion model to dioxin concentrations measured in ambient air. The exposure indicator was used in a case-control study within the E3N cohort to estimate the risk of breast cancer associated with atmospheric exposure to dioxins. It is currently being used in another study on cadmium exposure and breast cancer risk and may be applied in future studies on other pollutants or pathologies
Pillon, Arnaud. "Ligands environnementaux des récepteurs aux oestrogènes : développement d'outils de biosurveillance". Montpellier 1, 2004. http://www.theses.fr/2004MON13514.
Boudalia, Sofiane. "Exposition continue aux xéno-hormones à faibles doses chez le rat : effets multi-générationnels de mélanges sur les préférences gustatives, le comportement maternel et le développement". Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00866983.
Grignon, Claire. "Toxicocinétique en santé environnementale : application à la mesure de l'exposition aux perturbateurs endocriniens". Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT1405/document.
Bisphenol A (BPA), a well-known endocrine disruptor (ED), is ubiquitously found in the environment. The high reactivity of BPA with chlorine results in the formation of chlorinated derivatives of BPA (ClxBPA), having a higher endocrine disrupting activity than BPA. In the field of environmental health sciences, human risk assessment implies, in particular, to perform biomonitoring and toxicokinetic studies requiring the analysis of environmental micropollutants in biological matrices. To estimate population exposure to BPA and ClxBPA, a LC-MS/MS method to assay BPA and ClxBPA was validated in urine. This method was then modified to improve the speed and sensitivity of the assay, and was applied to the measurement of ED exposure in a cohort of pregnant women.Toxicokinetic studies of BPA report the formation of conjugates, excreted in urine. Conventionally, for the measurement of conjugated derivatives, indirect methods using enzymatic deconjugation are proposed. In this context, we have developed an original method for validating the deconjugation efficiency.If the indirect measurement of metabolites after deconjugation appears easier, it is more rationale to assay directly the metabolite. Therefore, after synthesis of analytical standards, we were able to develop, for the first time, a method for assaying glucuronides and sulfates BPA and Cl2BPA derivatives in urine.This work offers, especially through the development of analytical methods, reliable tools for assessing human exposure to ED