Bibliografías temáticas / Extracellular matrix (ECM) peptides

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Literatura académica sobre el tema "Extracellular matrix (ECM) peptides"

Autor: Grafiati

Publicado: 30 de noviembre de 2024

Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "Extracellular matrix (ECM) peptides"

Hozumi, Kentaro, and Motoyoshi Nomizu. "Mixed Peptide-Conjugated Chitosan Matrices as Multi-Receptor Targeted Cell-Adhesive Scaffolds." International Journal of Molecular Sciences 19, no. 9 (2018): 2713. http://dx.doi.org/10.3390/ijms19092713.

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Biomaterials are important for cell and tissue engineering. Chitosan is widely used as a scaffold because it is easily modified using its amino groups, can easily form a matrix, is stable under physiological conditions, and is inactive for cell adhesion. Chitosan is an excellent platform for peptide ligands, especially cell adhesive peptides derived from extracellular matrix (ECM) proteins. ECM proteins, such as collagen, fibronectin, and laminin, are multifunctional and have diverse cell attachment sites. Various cell adhesive peptides have been identified from the ECM proteins, and these are

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Tran, Thi Xuan Thuy, Gyu-Min Sun, Hue Vy An Tran, et al. "Synthetic Extracellular Matrix of Polyvinyl Alcohol Nanofibers for Three-Dimensional Cell Culture." Journal of Functional Biomaterials 15, no. 9 (2024): 262. http://dx.doi.org/10.3390/jfb15090262.

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An ideal extracellular matrix (ECM) replacement scaffold in a three-dimensional cell (3D) culture should induce in vivo-like interactions between the ECM and cultured cells. Highly hydrophilic polyvinyl alcohol (PVA) nanofibers disintegrate upon contact with water, resulting in the loss of their fibrous morphology in cell cultures. This can be resolved by using chemical crosslinkers and post-crosslinking. A crosslinked, water-stable, porous, and optically transparent PVA nanofibrous membrane (NM) supports the 3D growth of various cell types. The binding of cells attached to the porous PVA NM i

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Monteiro-Lobato, Gabriela M., Pedro S. T. Russo, Flavia V. Winck, and Luiz H. Catalani. "Proteomic Analysis of Decellularized Extracellular Matrix: Achieving a Competent Biomaterial for Osteogenesis." BioMed Research International 2022 (October 11, 2022): 1–18. http://dx.doi.org/10.1155/2022/6884370.

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Decellularized ECMs have been used as biological scaffolds for tissue repair due to their tissue-specific biochemical and mechanical composition, poorly simulated by other materials. It is used as patches and powders, and it could be further processed via enzymatic digestion under acidic conditions using pepsin. However, part of the bioactivity is lost during the digestion process due to protein denaturation. Here, stepwise digestion was developed to prepare a competent biomaterial for osteogenesis from three different ECM sources. In addition, three different proteases were compared to evalua

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Dolmatov, Igor Yu, and Vladimir A. Nizhnichenko. "Extracellular Matrix of Echinoderms." Marine Drugs 21, no. 7 (2023): 417. http://dx.doi.org/10.3390/md21070417.

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This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization. It includes a wide range of structural ECM proteins, as well as various proteases and their inhibitors. Members of almost all major groups of collagens, various glycoproteins, and proteoglycans have been found in echinoderms. There are enzymes for the synthesis of structural proteins and their modification by polysaccharides. However, the ECM of echinoderms substantially differs from that of vertebrates by the lack o

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Fujita, Motomichi, Manabu Sasada, Takuya Iyoda, Satoshi Osada, Hiroaki Kodama, and Fumio Fukai. "Biofunctional Peptide FNIII14: Therapeutic Potential." Encyclopedia 1, no. 2 (2021): 350–59. http://dx.doi.org/10.3390/encyclopedia1020029.

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Biofunctional peptide FNIII14, which is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule, is capable of inhibiting cell adhesion to the extracellular matrix (ECM). This functional site is usually buried within the molecular structure of FN, but can be exposed by conformational changes and proteolytic cleavage. Peptide FNIII14 can induce a conformational change in β1-integrin from the active to the inactive form, causing functional inactivation. Based on this anti-adhesive activity, peptide FNIII14 exhibits therapeutic potential for several diseases such as me

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Olivares-Navarrete, Rene, Sharon L. Hyzy, Argelia Almaguer-Flores, et al. "Amelogenin Peptide Extract Increases Differentiation and Angiogenic and Local Factor Production and Inhibits Apoptosis in Human Osteoblasts." ISRN Biomaterials 2013 (August 1, 2013): 1–11. http://dx.doi.org/10.5402/2013/347318.

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Enamel matrix derivative (EMD), a decellularized porcine extracellular matrix (ECM), is used clinically in periodontal tissue regeneration. Amelogenin, EMD’s principal component, spontaneously assembles into nanospheres in vivo, forming an ECM complex that releases proteolytically cleaved peptides. However, the role of amelogenin or amelogenin peptides in mediating osteoblast response to EMD is not clear. Human MG63 osteoblast-like cells or normal human osteoblasts were treated with recombinant human amelogenin or a 5 kDa tyrosine-rich amelogenin peptide (TRAP) isolated from EMD and the effect

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Merchant, Michael L., Michelle T. Barati, Dawn J. Caster, et al. "Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis." Journal of the American Society of Nephrology 31, no. 8 (2020): 1883–904. http://dx.doi.org/10.1681/asn.2019070696.

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BackgroundThe mechanisms leading to extracellular matrix (ECM) replacement of areas of glomerular capillaries in histologic variants of FSGS are unknown. This study used proteomics to test the hypothesis that glomerular ECM composition in collapsing FSGS (cFSGS) differs from that of other variants.MethodsECM proteins in glomeruli from biopsy specimens of patients with FSGS not otherwise specified (FSGS-NOS) or cFSGS and from normal controls were distinguished and quantified using mass spectrometry, verified and localized using immunohistochemistry (IHC) and confocal microscopy, and assessed fo

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Barnes, Ashlynn M., Tessa B. Holmstoen, Andrew J. Bonham, and Teisha J. Rowland. "Differentiating Human Pluripotent Stem Cells to Cardiomyocytes Using Purified Extracellular Matrix Proteins." Bioengineering 9, no. 12 (2022): 720. http://dx.doi.org/10.3390/bioengineering9120720.

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Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be differentiated into cardiomyocytes (hESC-CMs and iPSC-CMs, respectively), which hold great promise for cardiac regenerative medicine and disease modeling efforts. However, the most widely employed differentiation protocols require undefined substrates that are derived from xenogeneic (animal) products, contaminating resultant hESC- and iPSC-CM cultures with xenogeneic proteins and limiting their clinical applicability. Additionally, typical hESC- and iPSC-CM protocols produce CMs that are significantly contami

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Hulahan, Taylor S., Laura Spruill, Elizabeth N. Wallace, et al. "Extracellular Microenvironment Alterations in Ductal Carcinoma In Situ and Invasive Breast Cancer Pathologies by Multiplexed Spatial Proteomics." International Journal of Molecular Sciences 25, no. 12 (2024): 6748. http://dx.doi.org/10.3390/ijms25126748.

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Ductal carcinoma in situ (DCIS) is a heterogeneous breast disease that remains challenging to treat due to its unpredictable progression to invasive breast cancer (IBC). Contemporary literature has become increasingly focused on extracellular matrix (ECM) alterations with breast cancer progression. However, the spatial regulation of the ECM proteome in DCIS has yet to be investigated in relation to IBC. We hypothesized that DCIS and IBC present distinct ECM proteomes that could discriminate between these pathologies. Tissue sections of pure DCIS, mixed DCIS-IBC, or pure IBC (n = 22) with detai

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Mazzocchi, Andrea, Kyung Min Yoo, Kylie G. Nairon, et al. "Exploiting maleimide-functionalized hyaluronan hydrogels to test cellular responses to physical and biochemical stimuli." Biomedical Materials 17, no. 2 (2022): 025001. http://dx.doi.org/10.1088/1748-605x/ac45eb.

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Abstract Current in vitro three-dimensional (3D) models of liver tissue have been limited by the inability to study the effects of specific extracellular matrix (ECM) components on cell phenotypes. This is in part due to limitations in the availability of chemical modifications appropriate for this purpose. For example, hyaluronic acid (HA), which is a natural ECM component within the liver, lacks key ECM motifs (e.g. arginine–glycine–aspartic acid (RGD) peptides) that support cell adhesion. However, the addition of maleimide (Mal) groups to HA could facilitate the conjugation of ECM biomimeti

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Tesis sobre el tema "Extracellular matrix (ECM) peptides"

Maayouf, Hasna. "Développement de plateformes de signalisation dérivées de particules pseudo-virales pour contrôler les fonctions cellulaires." Electronic Thesis or Diss., Mulhouse, 2024. http://www.theses.fr/2024MULH7387.

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Diverses stratégies de fonctionnalisation de surface visent à améliorer la biocompatibilité des matériaux pour les dispositifs implantables, notamment en ingénierie tissulaire. Par exemple, le polydiméthylsiloxane (PDMS), bien qu’utilisé dans de nombreux domaines, présente des propriétés de surface défavorables à l’adhérence cellulaire. La fonctionnalisation par des protéines de la matrice extracellulaire (MEC) ou des peptides synthétiques dérivés de celles-ci permet d’améliorer l'adhérence des cellules. Bien que ces approches offrent certaines solutions, des défis tels que le coût de producti

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Kammerer, Theresa Anne [Verfasser], and Sebastian Johannes [Akademischer Betreuer] Arnold. "Visualization of the Extracellular Matrix (ECM) by fluorescent tagging of ECM components in mouse." Freiburg : Universität, 2021. http://d-nb.info/1232644803/34.

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Randles, Michael. "Proteomic analyses of kidney glomerular extracellular matrix in health and disease." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/proteomic-analyses-of-kidney-glomerular-extracellular-matrix-in-health-and-disease(a39fe408-db06-4d80-b97b-4e0651bf7bc3).html.

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Glomerular filtration is a vital physiological process removing waste products from the circulation and this process occurs across the glomerular filtration barrier (GFB). The cells and extracellular matrix (ECM), which form this barrier, are exposed to forces during ultrafiltration and special adaptation is required to withstand these forces. Dysfunction in cellular adhesion machinery or ECM assembly within the GFB causes loss of selective glomerular filtration, however, the mechanisms governing these processes are poorly understood. To this end we sought to characterise the glomerular ECM an

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Marengo, Kaitlyn A. "The Incorporation of Decellularized Cardiac ECM into Fibrin Microthreads." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-theses/843.

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Stem cell therapies have shown promising capabilities in regaining the functionality of scar tissue following a myocardial infarction. Biological sutures composed of fibrin have been shown to more effectively deliver human mesenchymal stem cells (hMSCs) to the heart when compared to traditional cell delivery mechanisms. While the biological sutures do show promise, improvements can be made. To enhance the fibrin sutures, we propose to incorporate native cardiac extracellular matrix (ECM) into the fibrin microthreads to produce a more in vivo-like environment. This project investigated the effe

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Villaggio, Giusy. "Relationship between extracellular matrix (ECM) components and mineralization in bone marrow stromal cells." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1492.

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The relations between cells and extracellular matrix seem to orchestrate tissue organization by regulating cell functions during fetal development and throughout normal adult life. Thus, focusing on the innate ability of the native ECM to better modulate cell behavior, the coating of synthetic biomaterials with cell-derived decellularized extracellular matrices is a promising approach to confer bioactivity to inert materials and direct the fate of host or transplanted cells in tissue engineering applications. This study aims to better understand ECM influence on human bone marrow stem cells an

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Kwak, Hyo Bum. "Exercise training regulation of extracellular matrix and remodeling in the aging rat heart." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2761.

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McKenna, Declan Joseph. "Studies of the 67 kilodalton laminin receptor in retinal vasculature." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300777.

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Singh, Mahipal, Cerrone R. Foster, Suman Dalal, and Krishna Singh. "Osteopontin: Role in Extracellular Matrix Deposition and Myocardial Remodeling Post-MI." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/8576.

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Remodeling after myocardial infarction (MI) associates with left ventricular (LV) dilation, decreased cardiac function and increased mortality. The dynamic synthesis and breakdown of extracellular matrix (ECM) proteins play a significant role in myocardial remodeling post-MI. Expression of osteopontin (OPN) increases in the heart post-MI. Evidence has been provided that lack of OPN induces LV dilation which associates with decreased collagen synthesis and deposition. Inhibition of matrix metalloproteinases, key players in ECM remodeling process post-MI, increased ECM deposition (fibrosis) and

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Brian, Irene. "Crosstalk between ECM mechanical cues and cellular metabolism." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3422721.

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Mechanical cues coming from the extracellular matrix (ECM) are key factors in the control of tissue homeostasis in physiology and disease. Cells can sense these physical cues and measure external resisting forces by adjusting their actomyosin cytoskeleton, which in turn regulates intracellular signalling pathways to orchestrate a proper cell response. Thus, ECM stiffness is important for many biological aspects such as proliferation, differentiation and migration. Very little is known instead, about its impact on cellular metabolism, and the molecular players involved in this process are large

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Bilem, Ibrahim. "Micro-engineered substrates as bone extracellular matrix mimics." Doctoral thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27329.

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Il est de plus en plus évident que la matrice extracellulaire (MEC), au-delà de sa fonction d’échafaudage cellulaire, génère des signaux de nature biochimique et biophysique jouant un rôle primordial au cours du processus de différenciation des cellules souches. A l’heure actuelle, plus de 15 différents facteurs extrinsèques (environnementaux), incluant l’organisation spatiale de la MEC, sa topographie, rigidité, porosité, biodégradabilité et chimie ont été identifiés comme modulateurs potentiels de la différenciation des cellules souches en lignées cellulaires spécialisées. Ainsi, il est plau

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Libros sobre el tema "Extracellular matrix (ECM) peptides"

(Editor), Nathan P. Colowick, Nathan P. Kaplan (Editor), and Leon W. Cunningham (Editor), eds. Structural and Contractile Proteins, Part E: Extracellular Matrix, Volume 145: Volume 145: Structural and Contractile Proteins Part E (Methods in Enzymology). Academic Press, 1987.

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Lennon, Rachel, and Neil Turner. The molecular basis of glomerular basement membrane disorders. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0320_update_001.

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The glomerular basement membrane (GBM) is a condensed network of extracellular matrix molecules which provides a scaffold and niche to support the function of the overlying glomerular cells. Within the glomerulus, the GBM separates the fenestrated endothelial cells, which line capillary walls from the epithelial cells or podocytes, which cover the outer aspect of the capillaries. In common with basement membranes throughout the body, the GBM contains core components including collagen IV, laminins, nidogens, and heparan sulphate proteoglycans. However, specific isoforms of these proteins are r

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MacGrogan, Donal, José Maria Pérez-Pomares, Bill Chaudhry, José Luis de la Pompa, and Deborah J. Henderson. From cushions to leaflets: morphogenesis of cardiac atrioventricular valves. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0017.

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At the looping stage of heart development, tissue patterning of myocardium and endocardium at the atrioventricular (AV) junction defines a morphogenic field competent to form valves that initially appear as protrusions of proteoglycan-rich extracellular matrix (ECM) called endocardial cushions (ECs) which are cellularized by an endocardial-mesenchymal transition (EMT). Cellular proliferation results in fusion of the major AV mesenchymal cushions and AV septation, whereas smaller cushions receive a supply from epicardially derived cells. These various sources of mesenchyme precursors give rise

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van der Vlag, Johan, and Jo H. M. Berden. The patient with systemic lupus erythematosus. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0161.

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical manifestations. The hallmark of SLE is the presence of antibodies against nuclear constituents, such as double-stranded (ds)DNA, histones, and nucleosomes. Local deposition of antinuclear antibodies in complex with nuclear autoantigens induces serious inflammatory conditions that can affect several tissues and organs, including the kidney.The levels of antinucleosome and anti-dsDNA antibodies seem to correlate with glomerulonephritis and these autoantibodies can often be detected years before the patient

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Capítulos de libros sobre el tema "Extracellular matrix (ECM) peptides"

Helm, Richard F., and Malcolm Potts. "Extracellular Matrix (ECM)." In Ecology of Cyanobacteria II. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-3855-3_18.

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Proske, Uwe, David L. Morgan, Tamara Hew-Butler, et al. "Extracellular Matrix (ECM)." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2389.

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Papanicolaou, Michael, and Thomas R. Cox. "Extracellular Matrix (ECM)." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-21573-6_5691-1.

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Papanicolaou, Michael, and Thomas R. Cox. "Extracellular Matrix (ECM)." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_5691.

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Balasubramanian, Swarnalatha, Elizabeth M. Powell, and Jennie B. Leach. "Investigating Cell-ECM Interactions and ECM Synthesis in Three-Dimensional Hydrogels." In Extracellular Matrix. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2083-9_10.

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Hennen, Eva, and Andreas Faissner. "Modulation of Neural Stem Cell Expressed Extracellular Matrix (ECM) by Targeting Glycosyltransferases." In Extracellular Matrix. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2083-9_13.

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Zhang, Xiaoming, and Michael P. Sarras. "ECM in Hydra Development and Regeneration." In Extracellular Matrix in Development. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-35935-4_7.

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Caravà, Elena, Cristiana Marcozzi, Barbara Bartolini, et al. "Method for Studying ECM Expression: In Situ RT-PCR." In The Extracellular Matrix. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9133-4_2.

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Ghorbani, Farnaz, Niyousha Davari, Chaozong Liu, and Behafarid Ghalandari. "Advances in ECM Protein-Based Materials." In Handbook of the Extracellular Matrix. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-56363-8_11.

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Actas de conferencias sobre el tema "Extracellular matrix (ECM) peptides"

Langley, Andrew, Allison Sweeney, Christopher Nguyen, Skye Edwards, Deeksha Sankepalle, and Srivalleesha Mallidi. "Non-invasive simultaneous assessment of therapy-induced tumor microenvironmental changes in collagen and vasculature with photoacoustic imaging." In Optical Molecular Probes, Imaging and Drug Delivery. Optica Publishing Group, 2025. https://doi.org/10.1364/omp.2025.om5e.2.

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The tumor microenvironment (TME) is critical for tumor cell survival and metastasis, comprising both cellular (immune and stromal cells) and non-cellular (extracellular matrix, ECM) components. Collagen within the ECM, produced by cancer-associated fibroblasts, fosters aggressive tumor phenotypes and confers resistance to chemotherapy. To enhance the efficacy of cancer therapies, various innovative strategies are being developed to normalize or target tumor collagen. We have previously demonstrated that photodynamic therapy (PDT) at low doses, termed photodynamic priming (PDP), can degrade col

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Almirall, L., J. Aznar-Salatti, I. Calopa, A. Ordinas, and E. Bastida. "ADHESION OF TUMOR CELLS TO EXTRACELLULAR MATRIX IS MEDIATED BY FIBRONECTIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643207.

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Tumor cell (TC) vessel wall adhesion is thougth to occur at specific sites of exposed extracellular matrix (ECM).To determine the role of fibronectin (FN) in TC/ECM adhesion,we measured; 1)TC adhesion to intact cultured endothelial cell monolayers (EC) or their ECMs,with or without incubation with a polyclonal antibody (Ab) to human FN, or a monoclonal antibody (Mab) to the cell binding site of FN (3E3);2)TC adhesion to EC or their exposed ECMs incubated with specific peptides against bacteria adhesion sites (I 133-79) or the peptide GRGDSP contained in the cell binding sites of several adhesi

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Rawal, Atul, Kristen L. Rhinehardt, and Ram V. Mohan. "Mechanical Behavior of Collagen Mimetic Peptides Under Fraying Deformation via Molecular Dynamics." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-11492.

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Abstract Collagen is a pervasive, triple helical, extracellular matrix (ECM) protein, found in human body from skin and bones to blood vessels and lungs, making it biocompatible, biodegradable, capable of cell attachment, and relevant for applications in bio-polymers, tissue engineering and a plethora of other bio-medical fields. Natural collagen’s extraction from natural sources is time consuming, sometimes costly, and it is difficult to render, and could present undesired biological and pathogenic changes. Nanoscale collagen mimetic peptides (Synthetic Collagen), without the unwanted biologi

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Hurley, Jennifer R., and Daria A. Narmoneva. "Endothelial-Fibroblast Interactions in Angiogenesis and Matrix Remodeling." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206534.

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Revascularization is critical for successful regeneration of ischemic cardiac tissue after injury. To achieve revascularization in engineered cardiac grafts, it is necessary to understand the interactions between major cardiac cell types. The importance of cardiomyocyte-endothelial interactions in angiogenesis is well documented [1]; however, less is known about interactions between endothelial and stromal cells, fibroblasts in particular. Studies indicate that during capillary assembly, fibroblasts (FBs) provide chemical signaling via growth factor expression and endothelial activation and pr

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Hurley, Jennifer R., Abdul Q. Sheikh, Meredith Beckenhaupt, Cameron Ingram, Andrew Mutchler, and Daria A. Narmoneva. "Self-Assembling Peptide Nanofibers for MMP Delivery and Cardiac Regeneration in Diabetes." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53761.

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Diabetes is a serious problem in the United States, afflicting 7.8% of the population with annual medical costs estimated at $116B in 2007 (1). Diabetic cardiomyopathy (DCM) is a cardiovascular complication of diabetes resulting in pathological alterations to the myocardium including circulatory defects, impaired heart muscle contraction, and progressive fibrosis. Cardiac fibrosis is associated with an imbalance between the deposition of the extracellular matrix (ECM) proteins by cardiac fibroblasts and the ECM proteolytic degradation via matrix metalloproteinases (MMPs). Recent studies have d

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Ciardelli, G., F. M. Montevecchi, P. Giusti, et al. "Molecular Imprinted Nanostructures in Biomedical Applications." In ASME 8th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2006. http://dx.doi.org/10.1115/esda2006-95669.

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Molecular imprinting is an emerging technology that allows to introduce nanostructured cavities into a polymer. In preparing molecular imprinted polymers (MIPs), the functional monomer(s) is first prearranged around the template molecule by specific interactions; the polymerisation is then carried out with a high percentage of cross-linking agent (which “freezes” the macromolecular network). Molecular mechanics and dynamics can be used to gain indications on the best monomers to be used in order to maximize interactions with the template. Once the polymerization reaction has been completed, th

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Freytes, Donald O., Samuel Kolman, Sachin S. Velankar, and Stephen F. Badylak. "Rheological Properties of Extracellular Matrix Derived Gels." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176537.

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Bioscaffolds composed of extracellular matrix (ECM) have been used for the repair of a variety of tissues often leading to tissue-specific constructive remodeling [1]. ECM scaffolds are typically prepared by decellularization of tissues and are composed of the structural proteins (e.g. collagen) and functional proteins (e.g. growth factors) that characterize the native ECM. However, for certain applications, the use of ECM scaffolds can be limited by the native two-dimensional sheet form in which they are harvested.

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Kong, AKCW, JMB Sand, DJ Leeming, et al. "S62 Extracellular matrix (ECM) remodelling in COPD." In British Thoracic Society Winter Meeting 2024, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 27 to 29 November 2024, Programme and Abstracts. BMJ Publishing Group Ltd and British Thoracic Society, 2024. http://dx.doi.org/10.1136/thorax-2024-btsabstracts.68.

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Roeder, Blayne A., Klod Kokini, Jennifer E. Sturgis, J. Paul Robinson, and Sherry L. Voytik-Harbin. "Micromechanics of Extracellular Matrix: Three-Dimensional Microstructure Under Load." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/bed-23165.

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Abstract The extracellular matrix (ECM) guides tissue form and function by communicating to cells both biochemical and mechanical information about the local micro-environment. It is well established that mechanical loads to tissues influence fundamental cellular processes including proliferation, migration, formation of adhesion complexes, and gene expression [1]. However, the pathway that transduces these forces from the tissue (macro) to the cellular (micro) level remains to be elucidated. In order to understand how cells interact mechanically with their surroundings, the three-dimensional

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Levine, R. F., A. Eldor, R. Stromberg, et al. "THE EFFECT OF FLOW ON THE INTERACTION OF ISOLATED MEGAKARYOCYTES WITH EXTRACELLULAR MATRIX." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644617.

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To examine the effect of flow on megakaryocytes (megas) exposed to extracellular matrix (ECM), we subjected megas on ECM to laminar flow in a chamber similar to that used to study platelets circulated over aortic subendothelium. Megas, harvested from guinea pig bone marrow by centrifugal elutriation and velocity sedimentation, were allowed to adhere to cover slips coated with ECM, which were then placed in a perfusion chamber. Medium was circulated over the megas on this surface for up to 18 hrs. The cells were examined during the experiments by phase contrast and afterwards by scanning electr

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Informes sobre el tema "Extracellular matrix (ECM) peptides"

Barash, Itamar, J. Mina Bissell, Alexander Faerman, and Moshe Shani. Modification of Milk Composition via Transgenesis: The Role of the Extracellular Matrix in Regulating Transgene Expression. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570558.bard.

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Altering milk composition via transgenesis depends on three main factors. (1) The availability of an efficient regulatory sequences for targeting transgene(s) to the mammary gland; (2) a reliable in vitro model to test the expression of transgenes prior to their introduction to the animal genome; and (3) better understanding of the major factors which determine the rate of gene expression and protein synthesis. The current studies provide the necessary means and knowledge to alter milk protein composition via transgenesis. The following specific goals were achieved: a: Identifying regulatory r

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Osathanon, Thanaphum. Gene expression profile of continuous and intermittent compressive stress treated human periodontal ligament cells. Faculty of Dentistry Chulalongkorn University, 2019. https://doi.org/10.58837/chula.res.2019.7.

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Mechanical force regulates periodontal ligament cell (PDL) behavior. However, different force types lead to distinct PDL responses. Here, we report that pretreatment with an intermittent compressive force (ICF), but not a continuous compressive force (CCF), promoted human PDL (hPDL) osteogenic differentiation as determined by osteogenic marker gene expression and mineral deposition in vitro. ICF-induced osterix (OSX) expression was inhibited by cycloheximide and monensin. Although CCF and ICF significantly increased extracellular adenosine triphosphate (ATP) levels, pretreatment with exogenous

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Cao, Siyang, Yihao Wei, Huihui Xu, et al. Crosstalk between Ferroptosis and Chondrocytes in Osteoarthritis: A Systematic Review of in-vivo and in-vitro Studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.3.0044.

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Review question / Objective: For the sake of better apprehending the nexus between ferroptosis and chondrocytes in osteoarthritis (OA), proffering novel insights and opening-up new orientation for in-depth research in both pre-clinical and clinical settings, it is warranted to initiate one rigorous and robust systematic review (SR) based upon up-to-date in-vivo and in-vitro research advances on this topic. To the best our knowledge, no SRs concerning ferroptosis and chondrocytes in OA have been published thus far. Condition being studied: Osteoarthritis (OA) is the most common form of arthriti

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