Bibliografías temáticas / Immunosuppressive agents Mechanism of action

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Literatura académica sobre el tema "Immunosuppressive agents Mechanism of action"

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Publicado: 4 de junio de 2021
Última modificación: 1 de febrero de 2022

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Artículos de revistas sobre el tema "Immunosuppressive agents Mechanism of action"

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McDevitt, Lisa M. "Immunosuppressive Agents on the Horizon." Journal of Pharmacy Practice 16, no. 6 (December 2003): 434–41. http://dx.doi.org/10.1177/0897190003259384.

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The evolution of immunosuppression in organ transplantation has resulted in decreasing rates of rejection and improved allograft survival. The current successes, however, comes at the price of intense drug monitoring, frequent adverse affects, and long-term toxicity. New immunosuppressive agents offer the hope for decreased toxicity and improved long-term results. This article highlights those novel agents that are currently in late-stage clinical studies including new calcineurin inhibitor analogs and formulations, mycophenolate acid sodium, everolimus, FK-778, FTY720, and various monoclonal
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Grbovic, Leposava, and Miroslav Radenkovic. "Therapeutic use of glucocorticoids and immunosuppressive agents." Srpski arhiv za celokupno lekarstvo 133, Suppl. 1 (2005): 67–73. http://dx.doi.org/10.2298/sarh05s1067g.

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Pharmacotherapy of autoimmune thyroid disease (AITD) is complex. Apart from the replacement hormone therapy, antithyroid agents, beta adrenoceptor blockers and other drugs, in regard to the present symptoms, it also includes the administration of glucocorticoids and immunosuppressive agents. Physiological actions of glucocorticoids are significant in number, well known and described in details. The most prominent pharmacological properties of glucocorticoids, that are important for their clinical use, are antiinflammatory and immunosuppressive actions. In this article, the most notable clinica
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Robak, Tadeusz, Ewa Lech-Maranda, Anna Korycka, and Ewa Robak. "Purine Nucleoside Analogs as Immunosuppressive and Antineoplastic Agents: Mechanism of Action and Clinical Activity." Current Medicinal Chemistry 13, no. 26 (November 1, 2006): 3165–89. http://dx.doi.org/10.2174/092986706778742918.

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Valdoleiros, Sofia R., Isabel Furtado, Carolina Silva, Inês Correia Gonçalves, André Santos Silva, Olga Vasconcelos, Ana Aboim Horta, et al. "Protocolo de Prevenção e Tratamento de Infeções Associadas à Terapêutica Imunossupressora de Doenças Autoimunes." Acta Médica Portuguesa 34, no. 6 (June 1, 2021): 469. http://dx.doi.org/10.20344/amp.15625.

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We propose a guideline about the risk, prevention and treatment of infection in the patient under immunomodulatory or immunosuppressive therapy in the context of autoimmune or autoinflammatory disease. It is divided into three sections: drugs and associated risk of infection; immunizations; risk, prevention, and treatment of specific infections. The treatment of autoimmune diseases involves the use of immunosuppressive or immunomodulatory therapies, with an increasing number of new drugs being used. It is associated with an increased risk of infection, which may be present globally or only for
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Bauer, Andrea C., Rodrigo F. Franco, and Roberto C. Manfro. "Immunosuppression in Kidney Transplantation: State of the Art and Current Protocols." Current Pharmaceutical Design 26, no. 28 (August 31, 2020): 3440–50. http://dx.doi.org/10.2174/1381612826666200521142448.

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Currently, kidney transplantation is the best treatment option for kidney failure for a majority of eligible patients. It is associated with a better quality of life and reduced mortality as compared to staying on dialysis. Many of the improvements in kidney transplant outcomes, observed in recent decades, are due to more efficient immunosuppression strategies. Therefore, developing expertise in the management of immunosuppressive drugs is key to the success of kidney transplantation. In this review, the historical aspects of organ transplant immunosuppression are briefly addressed and the bas
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Gorantla, Vijay S., John H. Barker, Jon W. Jones, Kaustubha Prabhune, Claudio Maldonado, and Darla K. Granger. "Immunosuppressive agents in transplantation: Mechanisms of action and current anti-rejection strategies." Microsurgery 20, no. 8 (2000): 420–29. http://dx.doi.org/10.1002/1098-2752(2000)20:8<420::aid-micr13>3.0.co;2-o.

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Taylor, Anna L., Christopher J. E. Watson, and J. Andrew Bradley. "Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy." Critical Reviews in Oncology/Hematology 56, no. 1 (October 2005): 23–46. http://dx.doi.org/10.1016/j.critrevonc.2005.03.012.

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Stepkowski, Stanislaw M. "Molecular targets for existing and novel immunosuppressive drugs." Expert Reviews in Molecular Medicine 2, no. 4 (June 21, 2000): 1–23. http://dx.doi.org/10.1017/s1462399400001769.

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Anti-neoplastic cytostatic antiproliferative agents, such as methotrexate, 6-mercaptopurine and cyclophosphamide, were originally used as immunosuppressive drugs. Although these agents induced only modest anti-rejection activity, they caused serious non-specific bone marrow suppression, impairing host resistance and increasing the incidence of infections. Unlike these non-selective agents, cyclosporine A, tacrolimus and sirolimus act more selectively on different stages of the T-lymphocyte (T-cell) and B-lymphocyte (B-cell) activation cycles; however, cyclosporine and tacrolimus are nephrotoxi
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Tan, Marcus, Thurston Heng, and Anselm Mak. "The Potential Use of Metformin, Dipyridamole, N-Acetylcysteine and Statins as Adjunctive Therapy for Systemic Lupus Erythematosus." Cells 8, no. 4 (April 6, 2019): 323. http://dx.doi.org/10.3390/cells8040323.

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Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune condition that can potentially affect every single organ during the course of the disease, leading to increased morbidity and mortality, and reduced health-related quality of life. While curative treatment is currently non-existent for SLE, therapeutic agents such as glucocorticoids, mycophenolate, azathioprine, cyclosporine, cyclophosphamide and various biologics are the mainstay of treatment based on their immunomodulatory and immunosuppressive properties. As a result of global immunosuppression, the side-effect profile
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Nelson, R. D., N. Shibata, R. P. Podzorski, and M. J. Herron. "Candida mannan: chemistry, suppression of cell-mediated immunity, and possible mechanisms of action." Clinical Microbiology Reviews 4, no. 1 (January 1991): 1–19. http://dx.doi.org/10.1128/cmr.4.1.1.

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The ability of Candida albicans to establish an infection involves multiple components of this fungal pathogen, but its ability to persist in host tissue may involve primarily the immunosuppressive property of a major cell wall glycoprotein, mannan. Mannan and oligosaccharide fragments of mannan are potent inhibitors of cell-mediated immunity and appear to reproduce the immune deficit of patients with the mucocutaneous form of candidiasis. However, neither the exact structures of these inhibitory species nor their mechanisms of action have yet been clearly defined. Different investigators have
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Tesis sobre el tema "Immunosuppressive agents Mechanism of action"

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Gudgeon, M. C. "Studies on the mechanism of action of cyclosporin A." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378279.

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Jones, Terence Edward. "Economically beneficial drug interactions with cyclosporin and tacroliumus : clinical studies in recipients of kidney and liver transplants." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phj79.pdf.

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Bibliography: leaves 234-257. Three separate clinical studies in organ transplant recipients are presented. The aims are to examine fundamental questions regarding the clinically and economically important pharmokinetic interaction between diltiazem and cyclosporin, an interaction widely utilised in organ transplantation. The data contained should assist the development of soundly based policies that will ensure a benefit exists before a sparing agent is coprescribed, and that the lowest effective dose of sparing agent is used.
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Lui, Sing-leung, and 雷聲亮. "The in vivo mechanism of actions of mycophenolate mofetil: insights from murine models of allograft rejection,endotoxemia, ischemia reperfusion injury and lupus nephritis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B26625374.

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Christie, Andrew W. "Mechanism of action of selected anti-lipolytic agents in adipocytes." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282761.

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Meister, Gabriel T. "Antiviral mechanism(s) of the experimental immunosuppressive agent leflunomide against human cytomegalovirus and polyomavirus." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1111428519.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 127 p.; also includes graphics (some col.) Includes bibliographical references (p. 113-127). Available online via OhioLINK's ETD Center
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Guo, Hong, and 郭紅. "Effects of anti-DNA antibodies on pleural mesothelial cells: in vitro studies to explore thepathogenetic mechanism of pulmonary lupus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B26631945.

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The Best M.Phil Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize, 2001-2003.<br>published_or_final_version<br>abstract<br>toc<br>Medicine<br>Master<br>Master of Philosophy
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Hearn, Jessica M. "Integrating cell screening and mechanism of action data for organometallic anticancer agents." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/68071/.

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Both acquired and intrinsic drug resistance are established clinical problems in many areas of medicine. This is particularly evident with the growing resistance to platinum chemotherapy agents in cancer treatment programmes. New, alternative treatments for platinum-resistance patients are needed, with comparable potency, no platinum cross- resistance, better safety profiles and which target non-repairable areas of the cell, reducing acquired resistance. This thesis focuses on osmium- and iridium-based organometallic anticancer agents to fill this clinical need. Previous work has validated the
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HAMED, SAJA H. "EFFICACY AND MECHANISM OF ACTION OF A NEW TYROSINASE INHIBITORY AGENT." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085566152.

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Lohmeyer, Matthias. "The mechanism of action of antitumour lipid agents related to platelet-activating factor (PAF)." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319528.

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Xia, Yixuan. "Anticancer efficacy and mechanism of action studies of the potent plant cycloheptapeptide compounds mavacyocines." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/817.

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Over the past 200 years, much attention has been paid to natural products for their great contribution in the industry of drug development as many of them have been shown effective against various diseased conditions in humans by virtue of their structural diversity and biological potency. Therefore, they are undeniably a rich resource for the discovery of novel bioactive compounds. To date, many of the mainstay anticancer agents often lead to undesirable side effects and/or develop rapid emergence of drug resistance. Therefore, new therapeutic remedies are desperately needed. In fact, many ac
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Libros sobre el tema "Immunosuppressive agents Mechanism of action"

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B, Strom T., ed. The mode of action of immunosuppressive agents. 2nd ed. Amsterdam: Elsevier Science Publishers, 1985.

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Bach, J. F. The mode of action of immunosuppressive agents. 2nd ed. Amsterdam: Elsevier, 1985.

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1937-, Toyama Junji, and Hondeghem Luc, eds. Current topics in antiarrhythmic agents: Mode of action and clinical usage : International Satellite Symposium of the 53rd Annual Meeting of the Japanese Circulation Society, Nagoya, Japan, March 27-28, 1989. Amsterdam: Excerpta Medica, 1989.

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Hiroshi, Takagi, ed. Regulatory roles of neuropeptides: Proceedings of the Sixth Workshop on Neurotransmitters and Diseases, Kobe, June 17, 1989. Amsterdam, The Netherlands: Excerpta Medica, 1989.

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M, Pinedo H., and Schornagel J. H, eds. Platinum and other metal coordination compounds in cancer chemotherapy 2. New York: Plenum Press, 1996.

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International Symposium on Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy (6th 1991 San Diego, Calif.). Platinum and other metal coordination compounds in cancer chemotherapy. New York: Plenum Press, 1991.

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S, Abraham, and Amitai G, eds. Calcium channel modulators in heart and smooth muscle: Basic mechanisms and pharmacological aspects : proceedings of the 33rd [i.e. 34th] Oholo Conference, Eilat, Israel, 1989. Rehovot, Israel: Balaban Publishers, 1990.

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Fever and antipyresis: The role of the nervous system. Cambridge: Cambridge University Press, 1995.

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Misbah, Siraj. Immunosuppressive therapy and therapeutic monoclonal antibodies. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0302.

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The term immunosuppressive therapy encompasses all forms of treatment that dampens function of the recipient’s immune system, with a view to controlling severe autoimmune, inflammatory, or allergic disease. The predominant targets of these agents are T-lymphocytes with multiple downstream effects, including containment of T-cell activation, inhibition of cytokine production, restriction of clonal expansion, and varying degrees of suppression of B-cell function. This chapter reviews the clinical use of monoclonal antibodies and other immunosuppressive agents, and their mechanisms of action.
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McCulloh, Russell J., and Steven M. Opal. Drug-induced depression of immunity in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0290.

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Immunosuppressive drugs are among the fastest-growing category of drugs in medicine today, both in terms of new medication development and in terms of use. Glucocorticoids, calcineurin inhibitors, and biological agents, among others, are used in a variety of diseases. . Although often of great benefit to patients, immunosuppressive agents also pose significant long-term risks for opportunistic infection. These drugs can also blunt normal host responses to infection, and patients receiving immunosuppressive medications are at high risk for severe illness, sepsis, and death from opportunistic in
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Capítulos de libros sobre el tema "Immunosuppressive agents Mechanism of action"

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Biollaz, J., A. Munafo, and T. Buclin. "Mechanism of Action of Vasodilating Agents." In Update in Intensive Care and Emergency Medicine, 275–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-83453-0_19.

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Rao, S. Ramachandra. "Mechanism of the Action of Modifying Agents." In Surface Chemistry of Froth Flotation, 575–619. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-1-4419-9124-9_12.

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Rao, S. Ramachandra. "Mechanism of the Action of Modifying Agents." In Surface Chemistry of Froth Flotation, 575–619. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-1-4757-4302-9_12.

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Kitz, R. J. "Anticholinesterase Agents: Their Mechanism of Action and Use." In Anesthesiology 1986, 11–14. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4251-6_3.

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Chatterjee, K. "Mechanism of Action of Inotropic Agents in Heart Failure." In Update in Intensive Care and Emergency Medicine, 213–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-83453-0_15.

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Koyama, Nobuhiro, and Hiroshi Tomoda. "Mechanism of Action of New Antiinfectious Agents from Microorganisms." In Chembiomolecular Science, 293–300. Tokyo: Springer Japan, 2012. http://dx.doi.org/10.1007/978-4-431-54038-0_29.

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Navarro, J., M. C. Grossetête, J. L. Touraine, and J. Traeger. "The Immunosuppressive Fraction Isolated from Uremic Ultrafiltrates: Attempted Characterization of the Mechanism of Action." In Advances in Experimental Medicine and Biology, 157–60. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5445-1_25.

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Kopia, G. A., and R. R. Ruffolo. "Mechanism of Action of Adrenergic Agents in Acute Congestive Heart Failure." In Update in Intensive Care and Emergency Medicine, 244–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-83453-0_17.

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Rees, K. R. "Mechanism of Action of Certain Exogenous Toxic Agents in Liver Cells." In Novartis Foundation Symposia, 53–73. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470719336.ch3.

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Alousi, Adawia A. "Classification and Mechanism of Action of the Cardiac Inotropic Agents: An Overview." In Developments in Cardiovascular Medicine, 331–40. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2057-9_26.

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Actas de conferencias sobre el tema "Immunosuppressive agents Mechanism of action"

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Ben-Hur, Ehud. "Phthalocyanines as photosensitizing agents for tumors--mechanism of action." In Europto Biomedical Optics '93, edited by Giulio Jori, Johan Moan, and Willem M. Star. SPIE, 1994. http://dx.doi.org/10.1117/12.168667.

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Delgado-Mata, Carlos, and Jesus Ibanez-Martinez. "An Emotion Affected Action Selection Mechanism for Multiple Virtual Agents." In 16th International Conference on Artificial Reality and Telexistence--Workshops (ICAT'06). IEEE, 2006. http://dx.doi.org/10.1109/icat.2006.37.

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Zihlif, Malek A., Laurence P. G. Wakelin, Daniel Catchpoole, and Bernard Stewart. "Abstract 744: Determining the mechanism of action of novel bisintercalating agents using the cDNA microarray technology." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-744.

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Hysi, Eno, Muhannad N. Fadhel, Anoja Giles, Yanjie Wang, Joseph A. Sebastian, Gregory J. Czarnota, Agata A. Exner, and Michael C. Kolios. "Fundamental studies comparing nanobubbles and microbubbles as vascular disrupting agents: Elucidating on the mechanism of action using photoacoustic imaging (Conference Presentation)." In Photons Plus Ultrasound: Imaging and Sensing 2020, edited by Alexander A. Oraevsky and Lihong V. Wang. SPIE, 2020. http://dx.doi.org/10.1117/12.2544302.

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Bara, L., J. M. Walen-ga, M. Petitou, M. Samama, J. Fareed, and J. Choay. "STUDIES ON THE MECHANISM OF THE ANTITHROMBOTIC ACTION OF A CHEMICALLY SYNTHESIZED HEPARIN PENTASACCHARIDE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644182.

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A chemically synthesized heparin pentasaccharide (PS) (Instir tut Choay, Paris, France) has been reported to exhibit an antithrombotic action in a rabbit stasis induced thrombosis model, in an IV dose range of 25-200 ug/kg (0.5 to 5 ug/ml circulating concentrations) . Ex vivo plasma analysis from treated animals revealed expected angi-factor Xa activity byboth amidolytic and coagulant (Heptest®) methods. Nodirect inhibitory effect against factor IIa by amidolytic or coagulant methods was observed. Global anticoagulant activities were not found by PT and APTT methods; however, a hypocoagulable
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Ardón, Paola, Èric Pairet, Katrin S. Lohan, Subramanian Ramamoorthy, and Ron P. A. Petrick. "Building Affordance Relations for Robotic Agents - A Review." In Thirtieth International Joint Conference on Artificial Intelligence {IJCAI-21}. California: International Joint Conferences on Artificial Intelligence Organization, 2021. http://dx.doi.org/10.24963/ijcai.2021/590.

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Affordances describe the possibilities for an agent to perform actions with an object. While the significance of the affordance concept has been previously studied from varied perspectives, such as psychology and cognitive science, these approaches are not always sufficient to enable direct transfer, in the sense of implementations, to artificial intelligence (AI)-based systems and robotics. However, many efforts have been made to pragmatically employ the concept of affordances, as it represents great potential for AI agents to effectively bridge perception to action. In this survey, we review
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Altman, Allison R., Beom Kang Huh, Abhishek Chandra, Wei-Ju Tseng, Ling Qin, and X. Sherry Liu. "3D In Vivo Bone Dynamic Imaging of PTH’s Anabolic Action." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14671.

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Aging shifts bone remodeling toward a negative balance between bone formation and resorption, causing bone loss and increased fracture risk. Anti-resorptive agents are commonly used to inhibit bone resorption and stabilize bone mass. While they are effective to prevent further bone loss, there is also a great need for anabolic agents which can reverse bone deterioration and regain lost skeletal integrity. Intermittent parathyroid hormone (PTH) treatment is the only FDA-approved anabolic treatment for osteoporosis, which greatly stimulates bone formation. Combined therapy of anti-resorptive dru
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Hu, Yujing, Yingfeng Chen, Changjie Fan, and Jianye Hao. "Explicitly Coordinated Policy Iteration." In Twenty-Eighth International Joint Conference on Artificial Intelligence {IJCAI-19}. California: International Joint Conferences on Artificial Intelligence Organization, 2019. http://dx.doi.org/10.24963/ijcai.2019/51.

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Coordination on an optimal policy between independent learners in fully cooperative stochastic games is difficult due to problems such as relative overgeneralization and miscoordination. Most state-of-the-art algorithms apply fusion heuristics on agents' optimistic and average rewards, by which coordination between agents can be achieved implicitly. However, such implicit coordination faces practical issues such as tedious parameter-tuning in real world applications. The lack of an explicit coordination mechanism may also lead to a low likelihood of coordination in problems with multiple optim
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Nikonov, G., and I. Baskova. "PROTECTIVE ANTITHROMBOTIC ACTION OF THE PREPARATIONS FROM THE LEECHES HIRUDO MED ICINAL IS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643079.

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Blood letting effect of the medicinal leeches is provided by antihaemostatic properties of the salivary gland secretion. We have demonstrated that the natural salivary gland secretion inhibits the vascular-platelets haemostasis and the contact stage of the intrinsic mechnism of blood coagulation but has no effect on the activation of extrinsic mechanism (Bui 1.Exp.Biol.Med.USSR 97, 6, 696; 8, 142, 1984). Leech prostaglandins (Dokl.Acad.Nauk USSR, 1987) and inhibitors of plasma kallikrein and Factor XI la are the main anti haemostatic agents of the leech saliva.The leech saliva does not change
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Maubert, Bastien, Sophie Pinchinat, Francois Schwarzentruber, and Silvia Stranieri. "Concurrent Games in Dynamic Epistemic Logic." In Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}. California: International Joint Conferences on Artificial Intelligence Organization, 2020. http://dx.doi.org/10.24963/ijcai.2020/260.

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Action models of Dynamic Epistemic Logic (DEL) represent precisely how actions are perceived by agents. DEL has recently been used to define infinite multi-player games, and it was shown that they can be solved in some cases. However, the dynamics being defined by the classic DEL update product for individual actions, only turn-based games have been considered so far. In this work we define a concurrent DEL product, propose a mechanism to resolve conflicts between actions, and define concurrent DEL games. As in the turn-based case, the obtained concurrent infinite game arenas can be finitely r
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