Bibliografías temáticas / Intratumoral CD8 T cells

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Literatura académica sobre el tema "Intratumoral CD8 T cells"

Autor: Grafiati
Publicado: 1 de febrero de 2025
Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "Intratumoral CD8 T cells"

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Yang, Zhi-Zhang, Anne J. Novak, Mary J. Stenson, Thomas E. Witzig, and Stephen M. Ansell. "Intratumoral Treg Cells Completely Inhibit the Induction and Function of Tumor-Infiltrating CD8+ T-Cells in B-Cell NHL." Blood 106, no. 11 (2005): 3311. http://dx.doi.org/10.1182/blood.v106.11.3311.3311.

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Abstract Background: Numerous studies have shown that lymphoma B-cells are resistant to CTL-mediated death, however the underlying mechanism for this resistance is not clear. In previous work, we have identified a subset of CD4+CD25+ T-cells overrepresented in the tumor sites of B-cell NHL that display a phenotype compatible with regulatory T cells (Treg cells). These cells express high levels of Foxp3 and CTLA-4, and are capable of suppressing the proliferation and cytokine production of autologous infiltrating CD4+CD25- T cells in B-cell NHL. Goal: To explore whether Treg cells exert a suppr
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De Logu, Francesco, Francesca Galli, Romina Nassini, et al. "Digital Immunophenotyping Predicts Disease Free and Overall Survival in Early Stage Melanoma Patients." Cells 10, no. 2 (2021): 422. http://dx.doi.org/10.3390/cells10020422.

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Background: the prognostic significance of tumor infiltrating lymphocytes (TILs) in intermediate/thick primary cutaneous melanoma (PCM) remains controversial, partially because conventional evaluation is not reliable, due to inter-observer variability and diverse scoring methods. We aimed to assess the prognostic impact of the density and spatial distribution of immune cells in early stage intermediate/thick PCM. Materials and Methods: digital image acquisition and quantitative analysis of tissue immune biomarkers (CD3, CD4, CD8, CD68, PD-L1, CD163, FOX-P3, and PD-1) was carried out in a train
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Wang, Li-Xin, Suyu Shu, Mary L. Disis, and Gregory E. Plautz. "Adoptive transfer of tumor-primed, in vitro–activated, CD4+ T effector cells (TEs) combined with CD8+ TEs provides intratumoral TE proliferation and synergistic antitumor response." Blood 109, no. 11 (2007): 4865–76. http://dx.doi.org/10.1182/blood-2006-09-045245.

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Abstract The importance of CD4+ Th1 cells during the effector phase of the antitumor response has been overshadowed by emphasis on CD8+ cytotoxic T lymphocytes (CTLs). To determine their respective functions, we purified antigen-primed T cells from tumor-draining lymph nodes and separately activated CD4+ and CD8+ subsets in vitro. Adoptive transfer of CD4+ T effector cells (TEs) combined with CD8+ TEs provided synergistic therapy for mice bearing subcutaneous, intracranial, or advanced pulmonary metastases. CD4+ TEs augmented IFN-γ production by CD8+ TEs when cells were stimulated by tumor dig
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Fenoglio, Daniela, Liliana Belgioia, Alessia Parodi, et al. "Development of Exhaustion and Acquisition of Regulatory Function by Infiltrating CD8+CD28− T Lymphocytes Dictate Clinical Outcome in Head and Neck Cancer." Cancers 13, no. 9 (2021): 2234. http://dx.doi.org/10.3390/cancers13092234.

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Head and neck squamous cell carcinoma (HNSCC) has a poor clinical outcome despite the presence of a rich CD8+ T cell tumor infiltrate in the majority of patients. This may be due to alterations of tumor infiltrating CD8+ T cells. Here, we performed a characterization of HNSCC infiltrating CD8+ T cells in a cohort of 30 patients. The results showed that differential intratumoral frequency of CD8+CD28+ T cells, CD8+CD28− T cells, and CD8+CD28−CD127−CD39+ Treg distinguished between HNSCC patients who did or did not respond to treatment. Moreover, high PD1 expression identified a CD8+CD28− T cell
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Yang, Zhi-Zhang, Anne J. Novak, Steven C. Ziesmer, Thomas E. Witzig, and Stephen M. Ansell. "CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25− T cells." Blood 110, no. 7 (2007): 2537–44. http://dx.doi.org/10.1182/blood-2007-03-082578.

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Foxp3 expression was initially thought to be restricted to the CD4+CD25+ regulatory T-cell population. However, recent studies suggest that forkhead box P3 (Foxp3) is expressed in CD4+CD25− T cells in aged mice. In the present study in B-cell non-Hodgkin lymphoma (NHL), we found that a subset of intratumoral but not peripheral blood CD4+CD25− T cells, comprising about 15% of intratumoral CD4+ T cells, express Foxp3 and are capable of suppressing the proliferation of autologous infiltrating CD8+ T cells. In vitro activation with OKT3/anti-CD28 antibody (Ab) or dendritic cells (DCs) induced Foxp
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Dorta-Estremera, Stephanie, Krishna Nookala Sita Mahalakshmi, Ananta V. Yanamandra, et al. "Kinetics of intratumoral T-cell activation during chemoradiation for cervical cancer." Journal of Clinical Oncology 36, no. 5_suppl (2018): 6. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.6.

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6 Background: Limited data in cancer patients have suggested that chemotherapy and radiation impact local and systemic immune cell populations. Radiation therapy (RT) is known to deplete circulating lymphocytes but is thought to increase local antigen presentation. The dynamics of these competing effects on the kinetics of intratumoral infiltration and expansion of activated and immunoregulatory T cells are unknown. Methods: We prospectively evaluated intratumoral immune infiltration during fractionated RT using multi-spectral flow cytometry. Cervical brushings were obtained from 14 patients b
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Yang, Jing, Jing Han, Zhen Jiang, et al. "Inhibition of Aurora-A recruited CD8+ T cells infiltration via mediating IL-10 production of cancer cells." Journal of Immunology 204, no. 1_Supplement (2020): 241.13. http://dx.doi.org/10.4049/jimmunol.204.supp.241.13.

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Abstract It has been shown that approximately 10% of infiltrated CD8+ T cells could be the tumor-specific intratumoral CD8+ T cells in colorectal cancer. While, inhibition of Aurora-A, a member of serine/threonine Aurora kinase family, by alisertib promoted the percentage of infiltrated intratumoral CD8+ T cells. We therefore assumed that targeting Aurora-A could be a therapeutic strategy for recruitment of intratumoral CD8+ T cells. In CT-26 tumor model, blockade of Aurora-A with alisertib slowed the tumor growth in association with an increased infiltration, activation and expansion of intra
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Gao, Qiang, Shuang-Jian Qiu, Jia Fan, et al. "Intratumoral Balance of Regulatory and Cytotoxic T Cells Is Associated With Prognosis of Hepatocellular Carcinoma After Resection." Journal of Clinical Oncology 25, no. 18 (2007): 2586–93. http://dx.doi.org/10.1200/jco.2006.09.4565.

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Purpose To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection. Patients and Methods CD3+, CD4+, CD8+, Foxp3-positive, and granzyme B-positive TILs were assessed by immunohistochemistry in tissue microarrays containing HCC from 302 patients. Prognostic effects of low- or high-density TIL subsets were evaluated by Cox regression and Kaplan-Meier analysis using median values as cutoff. Results CD3+, CD4+, CD8+ TILs were associated with neither overall survival (OS) nor disease
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Dimitrova, Polina, Mariela Vasileva-Slaveva, Velizar Shivarov, Ihsan Hasan, and Angel Yordanov. "Infiltration by Intratumor and Stromal CD8 and CD68 in Cervical Cancer." Medicina 59, no. 4 (2023): 728. http://dx.doi.org/10.3390/medicina59040728.

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Background and Objectives: The tumor microenvironment (TME) plays a major role in neoplastic development. Various types of cells can be found in the TME. These cells can be classified into two groups, immunosuppressive and immunostimulatory types, depending on the function they perform in the antitumor immune response (IR). By interacting both with each other and with tumor cells, different immune mechanisms are activated or inhibited, which can suppress or promote the development and progression of cervical cancer (CC). Our aim was to investigate some of the main components of the cellular im
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Zhang, Xinke, Suijing Wang, Run-Cong Nie, et al. "Immune Microenvironment Characteristics of Urachal Carcinoma and Its Implications for Prognosis and Immunotherapy." Cancers 14, no. 3 (2022): 615. http://dx.doi.org/10.3390/cancers14030615.

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Urachal carcinoma (UrC) is an exceedingly rare tumor and lacks effective treatment. Herein, we characterized an immune microenvironment characteristic of UrC in detail and identified its implications for prognosis and immunotherapy. In total, 37 resections of UrC were stained for CD20, CD3, CD4, CD8, FOXP3, CD68, HLA-DR, CD163, PD1, and PD-L1, as well as mismatch repair protein including MSH2, MSH6, MLH1, and PMS2 by immunohistochemistry. Intratumoral and peritumoral immune cell densities or the proportion of PD1 and PD-L1 expression alongside MSH2, MSH6, MLH1, and PMS2 status were manually ev
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Tesis sobre el tema "Intratumoral CD8 T cells"

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PARTINI, BIANCA. "Investigation of intratumoral cd8+ t cell spatiotemporal localization and function." Doctoral thesis, Università Vita-Salute San Raffaele, 2023. https://hdl.handle.net/20.500.11768/136738.

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CD8+ T cells play a crucial role in controlling liver tumours, such as hepatocellular carcinoma (HCC) however we have only limited knowledge of the precise dynamics of their interactions with hepatic parenchymal and non-parenchymal cells at the single-cell level. Previous work from our laboratory, demonstrated that in the context of HBV-expressing hepatocytes circulating effector CD8+ T cells (Teff) perform their immune surveillance function recognizing the antigen and kill virus-expressing hepatocytes extending cytoplasmic protrusions through endothelial fenestrations while still within live
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Cinier, Justine. "Importance et potentiel thérapeutique d'un nouveau couple récepteur-ligand dans l'inhibition des lymphocytes T CD8 par les lymphocytes T régulateurs dans les tumeurs." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10336.

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La présence de lymphocytes T (LT) CD8 dans le microenvironnement tumoral (TME) corrèle avec un bon pronostic dans de nombreux types de cancers solides. En périphérie, les LT régulateurs (Treg) jouent un rôle majeur dans le maintien d’une homéostasie immunitaire et empêchent le développement de pathologies auto-immunes. Néanmoins, dans le TME, les Treg (TA-Treg) ont un impact pronostic défavorable en inhibant la réponse immunitaire antitumorale. Sur le plan thérapeutique, il est indispensable d’éliminer ces TA-Treg ou leur fonction pour restaurer une réponse immunitaire antitumorale efficace. P
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Granier, Clémence. "Expression de récepteurs inhibiteurs sur les lymphocytes T infiltrant les tumeurs du rein : signification biologique et clinique Multiplexed immunofluorescence analysis and quantification of intratumoral PD-1+ Tim-3+ CD8+ T cells Tim-3 expression on tumor-infiltrating PD-1+CD8+ T cells correlates with poor clinical outcome in renal cell carcinoma." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB183.

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L'expression de récepteurs inhibiteurs tels PD-1, TIM-3, LAG-3, TIGIT sur les lymphocytes T participe à l'immunosuppression dans l'environnement tumoral. Le ciblage de PD-1 par les immunothérapies anti-PD-1/PD-L1 notamment révolutionne depuis peu la prise en charge de nombreux types de cancers en particulier dans le mélanome, cancer du poumon et aussi du rein. Dans la plupart des cancers comme dans celui du poumon et le mélanome, l'infiltrat CD8 et la réponse Th-1/IFN-gamma sont associés à un meilleur pronostic, contrairement aux tumeurs du rein et aux hémopathies. Les travaux de ma thèse s'in
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Sepulveda, Homero. "Activation requirements for CD8 T cells /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9907780.

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Mühle, Kerstin. "Interaction of CD8+CD40L+ T cells with B cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19127.

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ZTLs vermitteln die Eliminierung von infizierten und entarteten Zellen durch Apoptose. Neuste Erkenntnisse unserer Gruppe haben gezeigt, dass eine Subpopulation der CD8+ T-Zellen, anstelle der zytotoxischen Marker das Oberflächenmolekül CD40L exprimiert. Die Expression von CD40L ist bislang als Schlüsselmolekül für die CD4+ T-Zell vermittelte Hilfe bekannt, welche durch Bindung an den CD40 Rezeptor auf anderen Immunzellen induziert wird. Das von den CD4+ T–Zellen ausgehende CD40L Signal ist besonders für die T-Zell abhängige B-Zell Aktivierung und die Bildung von Keimzentren essentiell, in den
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Jarvis, Lorna Beth. "Autoreactive CD8+ regulatory T cells in spondyloarthritis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605067.

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There have been substantial advances in our understanding of the CD4+CD25+ regulatory T cell subset, but the possibility of an equivalent regulatory subset within the CD8+ T cell population has received less attention. In the course of studies investigating immunological abnormalities in patients with the inflammatory arthritis Ankylosing Spondylitis (AS), novel human CD8+ T cells that have a regulatory phenotype and function have been identified. CD8+/TCRαβ+ T cells were isolated from the peripheral blood of both AS patients and healthy donors and subsequently expanded as T cell lines using a
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Wangteeraprasert, Apirath. "CD8+ T-cells responses in Dengue virus infection." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39398.

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Dengue virus, which has four serotypes, has several clinical manifestations including asymptomatic infection, a self-limiting febrile illness termed dengue fever (DF) and a severe form characterized by plasma leakage termed dengue hemorrhagic fever (DHF). The pathogenesis of DHF is not fully understood and many studies have shown that it is more prevalent during secondary infection. In addition to a mechanism termed antibody dependent enhancement (ADE), the role of T-cells in the pathogenesis of dengue also has been investigated. It has been hypothesized that upon secondary infection dengue-sp
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Istaces, Nicolas. "Transcriptional control of innate memory CD8+ T cells." Doctoral thesis, Universite Libre de Bruxelles, 2019. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/295204.

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CD8+ T cells are essential for host protection against intracellular pathogens and tumors. During antigen-driven responses, CD8+ T cell fate is governed by transcriptional and epigenetic processes that allow naïve CD8+ T cells to develop into a wide range of effector and conventional memory cell subsets. Over the last decades, novel techniques and major efforts led to a better understanding of the origin, nature, and short- and long-term effects of these processes on individual CD8+ T cells. Under certain conditions, naïve CD8+ T cells can acquire memory phenotype and functions in an antigen-i
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Su, Charles. "Endogenous Memory CD8 T Cells in Cardiac Transplantation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1404079898.

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Raveney, Ben J. E. "Interactions between CD8+ T cells and bone marrow-derived dendritic cells." Thesis, University of Bristol, 2006. http://hdl.handle.net/1983/dbbc656f-a103-4787-aeb9-f203c3f0082b.

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Libros sobre el tema "Intratumoral CD8 T cells"

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Ford, Megan. The role and mechanism of B6/1pr TCR[alpha beta]+CD4-CD8- T cells in immune response regulation. National Library of Canada, 2001.

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Kay, Lyndsey Sara. Anti-B-cell lymphoma activity mediated by CD3+CD4-CD8- T cells activated in vitro or in vivo. National Library of Canada, 2003.

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Negative immunoregulatory role of CD8 T cells in peripheral tolerance. [Columbia University], 1993.

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Woodworth, Joshua. Class I MHC-restricted CD8+ T cells and host immunity to Mycobacterium tuberculosis. 2008.

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Datta, Syamal Kumar, Antonio La Cava, David A. Horwitz, and Ciriaco A. Piccirillo, eds. Generating and Sustaining Stable Autoantigen-specific CD4 and CD8 Regulatory T Cells in Lupus. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-788-7.

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Blaser, Claudine. Indentification and characterisation of differentially expressed genes in naive and activated CD8⁺ T cells. 1999.

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Arosa, Fernando A., ed. On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories. Frontiers Media SA, 2018. http://dx.doi.org/10.3389/978-2-88945-396-2.

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Dimier-Poisson, Isabelle. Major Role for CD8+T Cells in the Protection Against Toxoplasma gondii Following Dendritic Cell Vaccination. INTECH Open Access Publisher, 2012.

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Koh, Dow-Rhoon. The role of CD4+, CD8+ and CD4-8-T cells in murine experimental allergic encephalomyelitis and lupus. 1993.

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Young, Kevin J. The role and mechanisms of CD3+CD4-CD8-regulatory T cells in the suppression of allogeneic immune responses. 2003.

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Capítulos de libros sobre el tema "Intratumoral CD8 T cells"

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Kotlyar, David. "CD8 T Cells." In Cancer Therapeutic Targets. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4419-0717-2_93.

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Kotlyar, David. "CD8 T Cells." In Cancer Therapeutic Targets. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6613-0_93-1.

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Munitic, Ivana, César Evaristo, Hsueh Cheng Sung, and Benedita Rocha. "Transcriptional Regulation during CD8 T-Cell Immune Responses." In Memory T Cells. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6451-9_2.

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Boyman, Onur, Jae-Ho Cho, and Jonathan Sprent. "The Role of Interleukin-2 in Memory CD8 Cell Differentiation." In Memory T Cells. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6451-9_3.

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Friese, Manuel A., and Lars Fugger. "CD8+ T Cells in Multiple Sclerosis." In Immune Regulation and Immunotherapy in Autoimmune Disease. Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-36003-4_13.

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Out, Theo A., Francina L. de Pater-Huijsen, Henk M. Jansen, and Chris J. Corrigan. "CD8 T Cells: Potential Therapeutic Targets?" In New Drugs for Asthma, Allergy and COPD. KARGER, 2001. http://dx.doi.org/10.1159/000062177.

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Maherzi, C., F. Onodi, E. Tartour, M. Terme, and C. Tanchot. "Strategies to Reduce Intratumoral Regulatory T Cells." In Oncoimmunology. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62431-0_29.

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Kalia, Vandana, Surojit Sarkar, and Rafi Ahmed. "CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections." In Memory T Cells. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6451-9_7.

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Zanetti, Maurizio, Paola Castiglioni, and Elizabeth Ingulli. "Principles of Memory CD8 T-Cells Generation in Relation to Protective Immunity." In Memory T Cells. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6451-9_9.

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Kim, Edward Y., Stephen C. Juvet, and Li Zhang. "Regulatory CD4– CD8– Double Negative T Cells." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-869-0_6.

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Actas de conferencias sobre el tema "Intratumoral CD8 T cells"

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Fischer, Travis D., Caitlin D. Lemke-Miltner, and George J. Weiner. "1027 Intratumoral injection of vidutolimod, an immunostimulatory virus-like particle, enhances the number of intratumoral and circulating tumor-specific CD8 T cells." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.1027.

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Yamashita, Kimihiro, EIJI Fukuoka, Yutaka Sugita, et al. "Abstract 2260: Radiotherapy enhances newly infiltrating CD8+T cells into tumor tissue to increase intratumor CD8+T cells and exert an anti-tumor effects." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2260.

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Kato, Takuya, Kazuhiro Noma, Yuki Katsura, et al. "Abstract 1741: Cancer-associated fibroblasts regulate intratumoral CD8+/FoxP3+ T cells via interleukin 6 in the tumor immune microenvironment." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1741.

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Orlandella, Rachael M., Daniel L. Smith, and Lyse A. Norian. "Abstract 504: Acarbose enhances intratumoral CD8 T cell responses in a pre-clinical model of kidney cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-504.

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Orlandella, Rachael M., Daniel L. Smith, and Lyse A. Norian. "Abstract 504: Acarbose enhances intratumoral CD8 T cell responses in a pre-clinical model of kidney cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-504.

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Lammers, Marshall, Sean Judge, Lauren Farley, et al. "990 Context dependent effects of TIGIT expression on circulating versus intratumoral NK and CD8 T cells in mouse and human sarcoma models." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0990.

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Etxeberria, Inaki, Elixabet Bolaños, Alvaro Teijeira, et al. "Abstract 2331: Intratumor adoptive transfer of IL-12 mRNA transiently engineered anti-tumor CD8+ T cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2331.

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Etxeberria, Inaki, Elixabet Bolaños, Alvaro Teijeira, et al. "Abstract 2331: Intratumor adoptive transfer of IL-12 mRNA transiently engineered anti-tumor CD8+ T cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2331.

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Kalimutho, Murugan, та Kum Kum Khanna. "Abstract LB-256: PDGFRβ blockade bypasses resistance to combined MEK1/2-JAK2 inhibition in triple-negative breast cancer via intratumoral CD8+ T-cells infiltration". У Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-lb-256.

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Kalimutho, Murugan, та Kum Kum Khanna. "Abstract LB-256: PDGFRβ blockade bypasses resistance to combined MEK1/2-JAK2 inhibition in triple-negative breast cancer via intratumoral CD8+ T-cells infiltration". У Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-lb-256.

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Informes sobre el tema "Intratumoral CD8 T cells"

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รักษ์รุ่งธรรม, เกียรติ, สุปราณี บูรณประดิษฐ์กุล, ชุติธร เกตุลอย та เอกชัย พรหมเพชร. การศึกษาบทบาทของ subset T cells และ T follicular helper cells (TFH) ของ CD4+ T cells และ CD8+ T cells ในผู้ป่วยโรคไข้เลือดออกในคนไทย. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2013. https://doi.org/10.58837/chula.res.2013.19.

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Knutson, Keith L. CD8 T Cells and Immunoediting of Breast Cancer. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada624685.

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แก้วกิติณรงค์, กมล, та นิพนธ์ อุดมสันติสุข. บทบาทของ MAIT cells ในการควบคุมการติดเชื้อแบคทีเรีย Mycobacterium tuberculosis : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2016. https://doi.org/10.58837/chula.res.2016.28.

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วัณโรค (Tuberculosis) เป็นสาเหตุหลักของการเสียชีวิตจากโรคติดเชื้อของประชากรทั่วโลก (1) วัณโรคเกิดจากการติดเชื้อแบคทีเรีย Mycobacterium tuberculosis ภูมิต้านทานของร่างกายที่มีต่อเชื้อ Mycobacterium tuberculosis ประกอบด้วยเซลล์จากส่วนของ innate immunity และ adaptive immunity ในส่วนของ adaptive immunity กลุ่มของ T cells ที่มีส่วนสำคัญ ได้แก่ ทั้ง conventional T cells (ทั้ง CD8+ และ CD4+) และ non-conventional T cells (MAIT, NKT, CD1-restricted T cells) (2) MAIT (Mucosal-associated invariant T) cells จัดอยู่ในกลุ่มของ non-conventional T cells ที่พบได้ปริมาณมากตามเยื่อบุของร่างกาย รวมถึงปอด (3) นอกจ
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หังสสูต, ปกรัฐ, та ญาดา ตันสิริ. การวิเคราะห์การยับยั้งการเพิ่มจำนวนของไวรัสเอชไอวีโดยทีเซลล์ : การทดสอบที่ใช้วิเคราะห์ภูมิคุ้มกันที่ได้จากการกระตุ้นด้วยวัคซีนป้องกัน HIV : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2014. https://doi.org/10.58837/chula.res.2014.19.

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Introduction and Objective: Among HIV infected donors, the natural history of HIV infection is different and HIV load is the one of factors resulting in the different clinical outcome. We have been characterized HIV infected donors into 2 groups: controllers (HIV loads <2,000 copies/ml) and noncontrollers (HIV loads >2,000 copies/ml).In our previous study, we founded that controllers who naturally control HIV infection have the higher number of HIV-gag p24 specific T cells than noncontrollers significantly. Thus, We hypothesized that these polyfunctional T cells can effectively suppress
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Palaga, Tanapat, Nattiya Hirankarn, and Hathaipat Phuwapirom. Level of IL-17 in Thai SLE patients. Chulalongkorn University, 2009. https://doi.org/10.58837/chula.res.2009.30.

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Systemic Lupus Erythematosus (SLE) is an autoimmune disorder which affects various systems. Currently, the etiology of this disease has not been fully elucidated. One of potential causes which may play an important role is the defects in cytokine network and the functions of T lymphocytes. Previously, it was reported that SLE patients showed elevated elevated level of various cytokines such as IL-1β IL-6 IL-23. The aim of this study was to investigate the level of cytokine IL-17 which could be produced by various cell types including T lymphocytes CD4+ T lymphocytes mainly producing IL-17 form
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Lee, Chung, Timothy Kuzel, Richard Meagher, Ximing Yang, Norm Smith, and Qiang Zhang. Preparation for a Clinical Trial Using Adoptive Transfer of Tumor-Reactive TGF_Beta-Insensitive CD8+ T Cells for Treatment of Prostate Cancer. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada462885.

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Lee, Chung. Preparation for a Clinical Trial Using Adoptive Transfer of Tumor-Reactive TGF_Beta-Insensitive CD8+ T Cells for Treatment of Prostate Cancer. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada463479.

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cui, meng, zhiyong wan, jia yang, et al. Prognostic significance of programmed cell death 1 expression on CD8-T cells in various cancers: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2024. http://dx.doi.org/10.37766/inplasy2024.11.0075.

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หังสสูต, ปกรัฐ, та นวพล เตชะเกรียงไกร. บทบาทของทีเซลล์ต่อการวิวัฒนาการของเอชไอวี : ข้อมูลสำคัญสำหรับการพัฒนาวัคซีนป้องกันโรคเอดส์ : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2011. https://doi.org/10.58837/chula.res.2011.31.

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ในการพัฒนาวัคซีน HIV เราจำเป็นต้องมีความรู้ในกลไกการป้องกันการติดเชื้อไวรัสชนิดนี้ก่อนการศึกษาภูมิคุ้มกันในผู้ติดเชื้อ HIV ที่มีความสามารถในการควบคุมปริมาณ HIV ได้ตามธรรมชาติซึ่งมีปริมาณ HIV-RNA น้อยกว่า 2000 copies/ml สร้างโอกาสในการวิเคราะห์และค้นหาว่ากลไกอะไรที่ทำให้ผู้ติดเชื้อเหล่านี้สามารถควบคุมไวรัสได้ ผู้วิจัยรับสมัครผู้ที่ควบคุมไวรัสได้ดี (viraemic controllers, VC) จำนวน 13 คน และผู้ที่ควบคุมไวรัสได้ตามปกติ (typical progressor, TP) 32 คน อาสาสมัครทุกรายได้รับการวิเคราะห์ complete blood count, CD4 และ CD8 ตลอดจนปริมาณ plasma HIV-RNA ผู้วิจัยวิเคราะห์ลำดับกรดอะมิโนของโปรตีน p24 จากอาสาสม
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Banai, Menachem, and Gary Splitter. Molecular Characterization and Function of Brucella Immunodominant Proteins. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568100.bard.

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The BARD project was a continuation of a previous BARD funded research project. It was aimed at characterization of the 12kDa immunodominant protein and subsequently the cloning and expression of the gene in E. coli. Additional immunodominant proteins were sought among genomic B. abortus expression library clones using T-lymphocyte proliferation assay as a screening method. The 12kDa protein was identified as the L7/L12 ribosomal protein demonstrating in the first time the role a structural protein may play in the development of the host's immunity against the organism. The gene was cloned fro
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