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Tesis sobre el tema "Mitosis"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 25 de julio de 2025

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1

Ducháček, Ladislav. "Mitosis." Master's thesis, Vysoké učení technické v Brně. Fakulta výtvarných umění, 2016. http://www.nusl.cz/ntk/nusl-240615.

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Mitosis diploma work is figurative sculpture created by duplication statues. These duplicates to form pairs at each mitotic bind. Couples are composed into complex system, and thus form a spherical object. Against the background of this work is to introduce perspective on the human population and its culture as an independent organic whole.

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2

Breeden, Lauren N. "Mitosis : a collection." Honors in the Major Thesis, University of Central Florida, 2003. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/409.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Arts and Sciences<br>English

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3

Daniels, M. J. "Mechanisms regulating eukaryotic mitosis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598272.

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The fertilised egg gives rise to the entire organism through the coordination of high fidelity chromosome replication and then segregation. When this mechanism is corrupted cells acquire stable genetic mutations that absolve them from the normal proliferative impediments at work to keep the organism healthy. This is the basis of cancer. In order to understand and then rationally treat cancer we must understand the process of cell division. In this thesis I elucidate novel information pertaining to three mechanisms that guide a cell through the process of mitosis. Firstly as cells enter mitosis

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4

Sochaj, Alicja Maria. "Dissecting roles and regulation of the fission yeast kinetochore protein Spc7." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/7763.

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Accurate chromosome segregation is critical as unequal distribution of the genomic DNA results in impaired cell function or cell death. Kinetochores, the multi-protein structures assembled on centromeric DNA, drive chromosome segregation. Chromosome segregation is under supervision of mitotic spindle checkpoint. The mitotic spindle checkpoint is a surveillance mechanism ensuring that cells enter anaphase with all kinetochores properly attached to spindle microtubules and thereby preventing missegregation. Some checkpoint proteins are localised at kinetochore where they generate and enhance the

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5

Madriles, Gimeno Carles. "Mitosis based speculative multithreaded architectures." Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/124709.

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In the last decade, industry made a right-hand turn and shifted towards multi-core processor designs, also known as Chip-Multi-Processors (CMPs), in order to provide further performance improvements under a reasonable power budget, design complexity, and validation cost. Over the years, several processor vendors have come out with multi-core chips in their product lines and they have become mainstream, with the number of cores increasing in each processor generation. Multi-core processors improve the performance of applications by exploiting Thread Level Parallelism (TLP) while the Instructio

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6

Chakraborty, Papia. "Regulation of Nucleoporins in Mitosis." Scholarly Repository, 2007. http://scholarlyrepository.miami.edu/oa_dissertations/54.

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Nucleoporins mediate nucleocytoplasmic trafficking in interphase. In mitosis, upon nuclear envelope breakdown, the role and regulation of Nups remain to be elucidated. An important subcomplex of nucleoporins is the Nup107-160 complex, which, in mitosis, is involved in spindle assembly and nuclear pore re-assembly. Here we show that the level of a key constituent of the Nup107-160 complex- Nup96 is cell cycle regulated. We found that the mechanism involved in regulating Nup96 levels in mitosis is proteolysis by the anaphase-promoting complex (APC). Nup96 interacts with the APC, and its proteoly

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7

Martin, Carol-Anne. "Role of microcephalin at mitosis." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/8734.

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A large brain is one of the most distinguishing features of humans compared to other members of the animal kingdom. During mammalian evolution there has been a disproportionate enlargement of the brain relative to body size and this expansion has been particularly prominent during the past 3 million years of human lineage. This must be the consequence of adaptive genetic alterations during mammalian evolution, but the genes and molecular processes altered are essentially unknown. One approach for identifying candidate genes for brain size regulation is through characterisation of Mendelian dis

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8

ZUCCA, FEDERICO. "ASTRAL MICROTUBULE REGULATION IN MITOSIS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/790260.

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The faithful generation of two daughter cells genetically identical to each other relies on a complex cellular machinery called the mitotic spindle, which binds to each sister chromatid pair in a bipolar fashion and drives their segregation to the two newly generated daughters. The mitotic spindle is mainly composed of microtubules, microtubule-associated proteins and motor proteins. Spindle microtubules are conventionally divided into three different categories: (i) kinetochore microtubules (kMTs), which connect the spindle poles to chromosomes, (ii) interpolar microtubules (iMTs), which form

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9

Cortez, Beatriz de Araujo. "Interação da crisotila com células de carcinoma de pulmão humano em cultura: interferência com a mitose utilizando genes repórteres e microscopia em tempo real e estudo do potencial genotóxico." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-05042010-134617/.

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Asbesto é um nome geral dado a seis tipos de fibras minerais encontradas naturalmente na crosta terrestre. Estas fibras vêm sendo exploradas industrialmente desde 1970, porém diversos trabalhadores expostos às fibras apresentaram patologias no trato respiratório, como fibroses e carcinomas. Alguns tipos de fibra foram banidos do mercado, porém o tipo de asbesto crisotila ainda pode ser comercializado na maioria dos países. Estudos in vivo e in vitro tentam elucidar as alterações causadas pela exposição à asbesto nos tecidos e nas células que possam estar relacionadas ao aparecimento de doenças

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10

Masiá, Fandos Nuria. "Targeting mitosis in hormone-refractory prostate cancer." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670655.

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El CaP és la segona neoplàsia maligna invasiva diagnosticada amb major freqüència i la taxa de supervivència a 5 anys dels homes amb malaltia metastàtica cau per sota del 30%. Els andrògens, a través del receptor d'andrògens, són crucials per a l'inici i la progressió del CaP i, per tant, la ADT ha estat el principal tractament del CaP localment avançat, metastàtic i recurrent. Les teràpies de deprivació androgènica són capaces d'aconseguir inicialment una resposta bioquímica en la majoria dels pacients; no obstant això, les remissions són temporals i la malaltia acaba progressant a un estat i

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11

Moyano, Rodríguez Yolanda 1992. "Mitosis exit regulation by Cdc5 and PP2A-Cdc55." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668051.

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In this thesis we studied the role of PP2ACdc55 in the cytokinesis regulation and the contribution of Cdc5 kinase in the mitosis exit using budding yeast as model. Previously, it was suggested a putative PP2ACdc55 role in cytokinesis based on the elongated phenotype in absence of Cdc55. However, the PP2ACdc55 function during cytokinesis and its direct targets were not identified. In this thesis, we demonstrated that PP2ACdc55 regulates the IPC’s phosphorylation and their residence time at the bud neck. In addition, we showed that PP2ACdc55 coordinates actomyosin ring (AMR) contraction with sep

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12

Çetin, Bülent. "Chromosome segregation in mitosis and meiosis." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669990.

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13

Millar, S. E. "Polytenization and mitosis in Dipteran flies." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/47282.

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14

Yekezare, Mona. "Cdc20 and its regulation during mitosis." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611837.

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15

Pimenta-Marques, Ana. "Mitosis and protein Na-terminal acetylation." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2011. http://hdl.handle.net/10362/6179.

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Dissertation presented to obtain the Ph.D degree in Developmental Biology<br>Protein N-terminal acetylation is a highly conserved and widespread modification that occurs on approximately 80% of all soluble, cytoplasmic human proteins. Nevertheless, with few exceptions, little is known about the biological function of protein N- acetylation. Recently, it was suggested to act as a general protein destabilization signal in yeast (Hwang et al., 2010). Yet, other reports suggest it might act as stabilizer, for instance by blocking protein degradation (Ciechanover and Ben-Saadon, 2004). Thi

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16

Lian, Tsin Yee. "The role of IQGAP1 during mitosis." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/11813.

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Mitosis is a tightly regulated fundamental process and its mis-regulation is commonly associated with tumourigenesis. IQ-domain GTPase-activating Protein-1 (IQGAP1) is a scaffold protein that interacts with many proteins implicated in mitosis. IQGAP1 is essential for successful completion of cytokinesis in yeast but its role in mammalian mitosis remains unknown. The novel mitotic functions of IQGAP1 in mammalian cells were examined in this thesis. During mitosis, IQGAP1 phosphorylation at Ser-86, Ser-330 and Thr-1434 are significantly up-regulated. Thr-1434 is identified as a substrate of cycl

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17

Goss, Steven Philip Allan. "Ultrastructure and Mitosis of Glaucosphaera vacuolata." W&M ScholarWorks, 1993. https://scholarworks.wm.edu/etd/1539625804.

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18

Cannet, Aude. "Rôle du Rho-GEF Trio dans la division cellulaire." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20124.

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Durant la division cellulaire, la cellule subit des changements importants dans sa forme et son adhésion qui dépendent de l'efficacité du remodelage du cytosquelette d'actine. Ce processus est localement et temporellement régulé pour assurer le bon déroulement de la cytokinèse, l'étape finale de la division cellulaire. Il est contrôlé par les GTPases de la famille Rho via le remodelage du cytosquelette d'actine. Les Rho-GTPases fonctionnent comme des interrupteurs moléculaires, passant d'une forme au repos (liée au GDP) à une forme active (liée au GTP). La forme au repos interagit avec des fac

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19

Hewitt, Laura. "Using a novel small molecule inhibitor to investigate the role of Mps1 kinase activity." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/using-a-novel-small-molecule-inhibitor-to-investigate-the-role-of-mps1-kinase-activity(fcacfefc-90d9-4e92-9af4-a57897737329).html.

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During mitosis, accurate chromosome segregation is essential: gain or loss of genetic information can be detrimental to cell viability, or promote tumourigenesis. The mitotic checkpoint (also known as the spindle assembly checkpoint or SAC) ensures accurate chromosome segregation by delaying cell cycle progression until accuracy can be guaranteed. Mps1 is a protein kinase that is crucial for mitotic checkpoint signalling and also for proper chromosome alignment at metaphase. However, the precise role of Mps1’s catalytic activity is still unclear. Here, I present AZ3146, a novel small molecule

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20

McGuinness, Barry E. "Chromosome Segregation during Mammalian Mitosis and Meiosis." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490111.

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The spindle assembly checkpoint (SAC) functions to prevent anaphase onset until all chromosomes are correctly bi-oriented on the mitotic spindle and aligned at the metaphase plate. Cohesion between sister chromatids is essential for this biorientation. In animal cells, most cohesin is removed from chromosome arms during prophase and prometaphase. Cohesin at centromeres is refractory to removal at this stage and persists until metaphase, whereupon its Sccl subunit is cleaved by separase, which is thought to trigger anaphase. What protects centromeric cohesin from the prophase pathway? 1 show th

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21

Borlido, Joana Isabel Sarabando. "Exploring the relationship between clathrin and mitosis." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610622.

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22

Bennett, Ailsa. "Exploiting mitosis to improve anti-cancer strategies." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/exploiting-mitosis-to-improve-anticancer-strategies(b29182a1-2f37-47cb-8dc5-cbef76786dd2).html.

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Antimitotics are used in cancer chemotherapy for the treatment of cancers such as breast, ovarian, lung and prostate. Despite the success of agents such as Taxol, problems have emerged such as side effects, resistance and the lack of ability to predict patient responsiveness. As a result, a class of second-generation inhibitors have been developed with the aim to overcome or improve these issues. Such inhibitors target proteins and kinases involved in the control of mitosis and the cell cycle. However, these have yet to be clinically successful and therefore, this highlights the requirement fo

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23

Torres-Munoz, Keshia Nicole. "Regulation of Mitosis by Nuclear Speckle Proteins." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1341028309.

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24

Edelmaier, Christopher. "Computational Modeling of Mitosis in Fission Yeast." Thesis, University of Colorado at Boulder, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10837613.

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<p> Mitosis ensures the proper segregation of chromosomes into daughter cells, which is accomplished by the mitotic spindle. During fission yeast mitosis, chromosomes establish bi-orientation as the bipolar spindle assembles, meaning that sister kinetochores become attached to microtubules whose growth was initiated by the two sister poles. This process includes mechanisms that correct erroneous attachments made by the kinetochores during the attachment process. This thesis presents a 3D physical model of spindle assembly in a Brownian dynamics-kinetic Monte Carlo simulation framework and a re

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25

Kataria, M. "How does Cdc14 order exit from mitosis?" Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1542428/.

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Accurate progress through the cell cycle necessitates robust order and timing of events, the molecular basis for which is incompletely understood. During exit from mitosis, it is vital for cells to execute events in a precise sequence. Completion of chromosome segregation must precede chromatin decondensation, or indeed, cytokinesis. In budding yeast, the ordering of mitotic exit events is imposed by the changing balance between Cdk kinase activity, which begins to decline upon anaphase entry, and increasing activity of the major Cdk-counteracting phosphatase, Cdc14. In early anaphase, Cdk act

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26

Mangat, Davinderpreet Singh. "The regulation of Mps1 kinase during mitosis." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:80ced82c-6424-45a4-bdda-f83c270d3eeb.

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The spindle assembly checkpoint (SAC), a conserved surveillance system, ensures genomic stability by delaying anaphase entry until all sister chromatids are attached to the mitotic spindle. The SAC network is active at unattached kinetochores and a complex signalling cascade culminates in the production of a diffusible 'wait anaphase' signal. Regulation of protein:protein interactions by reversible phosphorylation is critical in this signalling pathway. The checkpoint kinase Mps1, a central regulator of the SAC, plays a positive role in enabling protein interactions. Mps1 builds the SAC networ

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27

Chan, Ying Wai. "Induction of mitotic cell death and cell cycle arrest by spindle disruption and premature entry into mitosis after DNA damage /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BICH%202007%20CHANY.

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28

Scrofani, Jacopo 1984. "Mechanism of RanGTP dependent microtubule assembly during mitosis." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/289621.

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During mitosis, spindle assembly involves different sources of microtubules including centrosomes and chromosomes. While the role of centrosomes has been extensively studied, we still do not fully understand how chromosomes trigger microtubule assembly thereby contributing to the formation of the mitotic spindle. The chromosomal pathway is largely determined by a RanGTP gradient centered on the chromosomes that induces the local activation of spindle assembly factors. To get a better understanding on the RanGTP-dependent microtubule assembly during mitosis we aimed at: i) Identifying new Ran

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29

Lecland, Nicolas 1984. "Non-centrosomal microtubule nucleation and organization in mitosis." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/299799.

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During mitotic spindle assembly, γ-tubulin ring complexes (γTuRCs) nucleate microtubules at the centrosome, around mitotic chromatin and, by augmindependent recruitment, from pre-existing microtubules. The analysis of these distinct pathways in somatic cells is challenging due to the predominance of centrosomal nucleation. It is also unknown how microtubules derived from different nucleation pathways are organized into the bipolar spindle structure. Minus ends were shown to be present throughout the spindle with a higher concentration near the poles. However, the analysis of minus end d

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30

Heubes, Simone. "The AAA-ATPase p97 in mitosis and fertilization." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-76361.

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31

Leibowitz, Mark Harold. "Aurora : a gene essential for mitosis in Drosophila." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46409.

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32

Zhang, Xin. "Spatial and temporal phosphoregulation of MCAK during mitosis." [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3264319.

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Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2007.<br>Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 2766. Adviser: Claire E. Walczak. "Title from dissertation home page (viewed Jan. 24, 2008)."

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33

Hanson, K. K. "Regulation of Wingless signaling and mitosis in Drosophila." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603670.

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In order to identify new regulators of the Wg signaling pathway, others in the Bienz laboratory carried out an EMS screen to find modifiers of the phenotype caused by expression of a stable Armadillo transgene in the <i>Drosophila </i>eye. I proceeded with the characterization of a number of mutants that resulted from this screen, and identified one enhancing complementation group as alleles of <i>sine oculis (so). </i>So is a homeodomain containing protein, chiefly characterized as a member of the retinal gene determination network, a group of transcription factors that direct eye developmen

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34

Kwan, Pak-shing, and 關百誠. "Roles of Daxx in mitosis and prostate carcinogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085337.

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35

Barton, Richard Christopher. "Microtubules, mitosis and chromosome segregation in Candida albicans." Thesis, University of Kent, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.256985.

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36

Riaz, Abida. "Cyclin B in fission yeast mitosis and meiosis." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286160.

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37

Falk, Jill E. "Mechanisms underlying spatial control of exit from mitosis." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103238.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.<br>DVD-ROM contains 4 supplemental movies (mov.) for Chapter III.<br>Both MIT Institute Archives and Science Library copy: with DVD-ROM.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>During mitosis, cells must accurately segregate their genome in order to produce healthy daughter cells. In budding yeast, cells align their anaphase spindle along a predetermined axis of division in order to partition their genome into the daughter cells. In the event that the spindle becomes

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38

Marco-Casanova, Paola. "Chemical genetics to study how cells enter mitosis." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609995.

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39

Richardson, Josephine Lydia. "Cyclin B1 regulation in mitosis : dynamics and destruction." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614894.

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40

Alharbi, Ibrahim. "Investigating Haspin-dependent phosphorylation of histones during mitosis." Doctoral thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/66558.

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La protéine Haspine est une sérine / thréonine kinase mitotique conservée, connue pour fonctionner par la phosphorylation de l'histone H3 (H3pT3). Bien que H3T3 soit le seul substrat bien connu de Haspine, il se peut que H3pT3 ne suffise pas à expliquer toutes les fonctions de Haspine au cours de la mitose. Fait intéressant, l’homologie de la portion N-terminale de H3 avec la portion Cterminale de H2B suggère que la thréonine 119 de H2B (H2BT119) est un candidat potentiel fort pour être un substrat majeur de Haspine. Ainsi, l’objectif de ce projet était d’étudier la phosphorylation de H2BT119

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41

Smith, Amy Elisabeth. "The centriole in evolution : from motility to mitosis." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:f48e77ea-fbf9-4ac6-b86e-854f6739a5aa.

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Centrioles and basal bodies with their characteristic 9+2 structure are found in all major eukaryotic lineages. The correlation between the occurrence of centrioles and the presence of cilia/flagella, but not centrosome-like structures, suggests that the ciliogenesis function of centrioles is ancestral. Here, it is demonstrated that the centriole domain of centrosomes emerged within the Metazoa from an ancestral state of possessing a centriole with basal body function but no functional association with a centrosome. Centrosome structures involving a centriole are metazoan innovations. Whe

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42

Kwan, Pak-shing. "Roles of Daxx in mitosis and prostate carcinogenesis." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085337.

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43

Sinha, Anupam. "Studies on the isolation and culture of Lupin (Lupinus albus) protoplasts." Thesis, University of Reading, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297700.

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44

Miller, Andrew S. "The control of morphogenesis in Drosophila imaginal disc cell lines in vitro." Thesis, University of St Andrews, 1996. http://hdl.handle.net/10023/14026.

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The experimental component of this thesis represents the continuation of studies carried out in the Milner laboratory to characterise the biology of Drosophila imaginal disc cell lines growing in vitro. The bulk of this study was concerned with the morphological and molecular characterisation of imaginal cell interactions in vitro and contrasting this with what is known of imaginal cell biology in vivo. The imaginal cell lines were thus seen as both an amenable model for the detailed analysis of a cells interaction with its environment and, more broadly, as an assessment of the effects of isol

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45

Bielska, Olga. "The role of PKD in mitochondrial fission during mitosis." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ009.

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Plusieurs études ont découvert et renforcé l'implication de la dynamique mitochondriale dans le cancer. J'ai découvert un rôle inattendu des protéines kinases de la famille PKD dans la fission mitochondriale. La perte de l'activité PKD a conduit à un blocage de la fission et a entraîné une élongation significative des mitochondries par fusion continue. D'un point de vue mécanique, nous avons montré que les protéines PKD régulent la dynamique mitochondriale en activant le facteur de fission mitochondrial (MFF) par phosphorylation de plusieurs sites. MFF agit comme un récepteur principal de la G

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46

Ma, Sheng. "Caractérisation du rôle des protéines phosphatases impliquées dans la déphosphorylation de la protéine kinase Greatwall lors de la sortie de mitose." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS007/document.

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Chez la drolosophile, des mutants de Greatwall présentent des défauts de condensation des chromosomes lors de la mitose. Plus tard, la même équipe a montré que chez le Xénope, Greatwall est nécessaire pour entrer en mitose. L'idée consistant à penser que puisque Greatwall ne permet plus l'entrée en mitose, il joue un rôle dans la boucle qui conduit à l'auto-amplification de MPF. En 2009, notre équipe a montré que Greatwall est réellement impliquée dans l'entrée en mitose, mais de façon indirecte par rapport à la boucle d'amplification de MPF, et cela en contrôlant l'activité de la phosphatase

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Bouguenina, Mohammed El Habib. "La protéine SMYLE (Short MYomegalin Like EB1 binding protein) dans l'organisation d'un complexe centrosomal, la régulation de la nucléation et la stabilisation des microtubules : conséquences sur la migration et la division des cellules cancéreuses." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5060.

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Les microtubules (MT) sont des polymères dynamiques ancrés par leurs extrémités moins aux centres de nucléation alors que leurs extrémités plus, explorent le cytoplasme, jusqu’à être stabilisées. Cette capture des extrémités permet l’organisation du réseau des MT. Les +TIP sont un groupe de protéines qui s’associent aux bouts plus des MT. EB1 est une protéine centrale dans le réseau des +TIP qui régule la dynamique des MT et leur interaction avec les structures d’ancrage des extrémités plus. Par protéomique ciblée, nous avons caractérisé l’interactome d’EB1, et mis en évidence un groupe de pro

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Lerner, Jonathan. "Caractérisation de l’effet de mutations MODY sur la fonction de bookmarking de HNF1beta." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T064/document.

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HNF1beta est un facteur de transcription homeobox, dont les mutations sont fréquemment rencontrées chez des patients atteints d’anomalies congénitales du rein et du tractus urinaire (Congenital Abnomalities of the Kidney and the Urogenital Tract, CAKUT). HNF1beta est également impliqué dans le diabète de type Maturity Onset Diabetes of the Young 5 (MODY5). Le laboratoire d’accueil a démontré que HNF1beta était impliqué dans un mécanisme épigénétique, le Bookmarking, nécessaire à la réexpression post-mitotique de ses gènes cibles. En particulier, des expériences de vidéo-microscopie ont montré

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Feizbakhsh, Omid. "La protéine Kinase Haspine comme nouvelle cible thérapeutique : analyse de ses fonctions et caractérisation d'inhibiteurs spécifiques." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B053.

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Depuis sa découverte en 1994, la protéine kinase Haspine fait l’objet d’un intérêt scientifique croissant en raison de son rôle clé dans la mitose. Elle est impliquée dans localisation et l’activation spatio-temporel d’Aurora B en créant un site d’ancrage (phosphorylation de l’Histone H3 sur la Thr3) sur les chromosomes et notamment aux centromères en première partie de mitose. Une perte d’activité de l’Haspine s’accompagne irrémédiablement d’erreurs dans l'alignement des chromosomes, la cohésion centromérique et l'intégrité des fuseaux mitotiques. Ces fonctions en fait une cible thérapeutique

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Schütz, Martin Maximilian. "The role of NIMA-like kinase Nek9 in mitosis." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/38705.

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Mitosis is the essential process during which a cell divides into two viable daughter cells. To allow a faithful segregation of the chromosomes into each daughter, the cell forms the bipolar spindle. The NIMA-like kinase family member Nek9 has been previously proposed to play a role in bipolar spindle assembly and in the chromosomal pathway of microtubule assembly. We aimed at gaining a better understanding of Nek9 function by characterizing Xenopus Nek9, xNek9, using the Xenopus egg extract system. We have shown that xNek9 may not act through the kinase cascade xNek9 – xNek6 in meiosis as

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