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Literatura académica sobre el tema "Mycobacterium tuberculosis σ Factors"

Autor: Grafiati

Publicado: 6 de septiembre de 2023

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Tesis sobre el tema "Mycobacterium tuberculosis σ Factors"

1

Moses, Lorraine. "Phenotypic factors influencing Mycobacterium tuberculosis phenotype." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52997.

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Davies, Angharad Puw. "A study of resuscitation-promoting factors in Mycobacterium tuberculosis." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445460/.

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Tuberculosis is a major threat to human health. About one third of the world's population is latently infected with Mycobacterium tuberculosis . In these cases the bacillus is in a state of low metabolic activity, making eradication difficult with conventional chemotherapy, which targets actively metabolizing organisms. The mechanisms by which M. tuberculosis reactivates to cause disease are currently unknown but a better understanding could greatly improve the treatment of tuberculosis. Resuscitation-promoting factor is a protein first identified in the supernatant of stationary phase culture

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3

Hanekom, Madeleine. "The molecular epidemiology of Mycobacterium tuberculosis : host and bacterial factors perpetuating the epidemic." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/4821.

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Thesis (PhD (Biomedical Sciences. Molecular Biology and Human Genetics))--University of Stellenbosch, 2009.<br>Dissertation presented for the degree of Doctor of Philosophy at Stellenbosch University.<br>ENGLISH ABSTRACT: This study describes the molecular epidemiology of Mycobacterium tuberculosis strains with the Beijing genotype. This genotype has received clinical prominence due to its global distribution and the hypothesis that these strains have acquired the ability to evade the protective effect of BCG vaccination, spread more readily, acquire drug resistance and cause severe forms o

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4

Tanina, ABDALKARIM. "Structural analysis of transcription factors involved in Mycobacterium tuberculosis mycolic acid biosynthesis." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/309485.

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Tuberculosis (TB) remains the leading cause of death due to a single infectious agent with more than 1.5 million people killed each year. In 2018, the World Health Organization (WHO) estimated that one third of the world’s population was infected with Mycobacterium tuberculosis (Mtb), the pathogen responsible for the disease.In 2000, EthR, a mycobacterial transcriptional repressor, was identified as a key modulator of ethionamide (ETH) bioactivation. ETH is one of the main second-line drugs used to treat drug-resistant strains and it is a prodrug that is activated in Mtb by the mono-oxygenase

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5

AlcÃntara, Cid Carlos Soares de. "Fatores associados ao diagnÃstico de tuberculose pulmonar entre suspeitos da doenÃa na rotina de unidades de saÃde de Fortaleza, CE." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5815.

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A Tuberculose (Tb) Ã uma doenÃa que tem desafiado a humanidade desde a antiguidade. Acreditava-se que com as novas tecnologias, as doenÃas infecto-contagiosas seriam facilmente controladas e banidas. A realidade, porÃm tem-se apresentado de modo diferente; apesar dos avanÃos no conhecimento da tuberculose e tecnologia disponÃvel para seu controle, o quadro atual encontra-se muito distante das metas estabelecidas pelos governos. Ã essencial o estudo dos fatores associados Ã tuberculose pulmonar, uma vez que eles estÃo presentes na primo-infeccÃÃo, na recidiva e na Tb pulmonar multi-resistente.

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6

Crossman, David K. "Characterization of a novel acetyltransferase found only in pathogenic strains of Mycobacterium tuberculosis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007r/crossman.pdf.

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7

Kocabas, Evren. "Identification of native co-factors of MshB and MCA from Mycobacterium species." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/44457.

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Mycothiol (MSH), a low-molecular- weight thiol, is a primary reducing agent and essential for the survival of mycobacteria. The full pathway of MSH biosynthesis and detoxification includes various promising drug targets. Several metalloenzymes are involved in this pathway, such as a deacetylase (MshB) and mycothiol S-conjugate amidase (MCA). MshB catalyzes the deacetylation of GlcNAc-Ins to form GlcN-Ins and acetate. Mycothiol S-conjugate amidase (MCA) cleaves the amide bond of mycothiol S-conjugates of various drugs and toxins. The identification of the native co-factor is critical for the de

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8

Dupont, Maeva. "Identification of novel factors involved in the exacerbation of HIV-1 infection and spread among macrophages in the tuberculosis context." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30211.

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Mycobacterium tuberculosis (Mtb), la bactérie responsable de la tuberculose (TB), et le virus de l'immunodéficience humaine (VIH-1), l'agent du syndrome de l'immunodéficience acquise (SIDA), accélèrent leurs progressions mutuelles chez les patients co-infectés. Alors que de nombreuses données cliniques rapportent une augmentation de la charge virale dans les sites anatomiques co-infectés, les mécanismes qui en sont responsables restent insuffisamment décrits. Mtb cible principalement les macrophages. Nous émettons l'hypothèse que l'infection des macrophages par Mtb créé un microenvironnement p

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9

Bortoluzzi, Alessio. "Structural characterization of Mycobacterium tuberculosis RNA polymerase binding protein A (RbpA) and its interactions with sigma factors." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28401.

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The RNA polymerase binding protein A (RbpA) is a 13 kDa protein, encoded by the gene Rv2050, that was shown to be essential for the growth and survival of the important human pathogen Mycobacterium tuberculosis. Although is not clear yet why RbpA is essential in M. tuberculosis, significant progress has been made in the characterization of the protein. For instance, it was shown that RbpA binds to the β-subunit of the RNA polymerase (RNAP) and activates transcription. Interestingly, it was reported that RbpA can enhance the transcription activity of the RNAP containing the primary σ-subunit σ[

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10

Molino, Lucilia Pereira Dutra. "Infecção latente por Mycobacterium tuberculosis entre contatos de pacientes com tuberculose pulmonar cavitária e não cavitária." Universidade Federal do Espírito Santo, 2009. http://repositorio.ufes.br/handle/10/5917.

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Made available in DSpace on 2016-12-23T13:56:04Z (GMT). No. of bitstreams: 1 DISSERTACAO FINAL.pdf: 1304058 bytes, checksum: 22df93a24605e7e83e388686a27fb38f (MD5) Previous issue date: 2009-05-29<br>The tuberculosis continues to represent a severe worldwide public health issue, particularly in developing countries. Besides early diagnosis and therapy, one of the great challenges for its control is the scarce knowledge available about the transmission mechanisms and the related risks. The retrospective cohort described in this study aims to evaluate the risk of Mycobacterium tuberculosis infe

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