Bibliografías temáticas / NS4B protein

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Literatura académica sobre el tema "NS4B protein"

Autor: Grafiati

Publicado: 7 de diciembre de 2024

Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "NS4B protein"

Zou, Jing, Xuping Xie, Qing-Yin Wang, et al. "Characterization of Dengue Virus NS4A and NS4B Protein Interaction." Journal of Virology 89, no. 7 (2015): 3455–70. http://dx.doi.org/10.1128/jvi.03453-14.

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ABSTRACTFlavivirus replication is mediated by a membrane-associated replication complex where viral membrane proteins NS2A, NS2B, NS4A, and NS4B serve as the scaffold for the replication complex formation. Here, we used dengue virus serotype 2 (DENV-2) as a model to characterize viral NS4A-NS4B interaction. NS4A interacts with NS4B in virus-infected cells and in cells transiently expressing NS4A and NS4B in the absence of other viral proteins. Recombinant NS4A and NS4B proteins directly bind to each other with an estimatedKd(dissociation constant) of 50 nM. Amino acids 40 to 76 (spanning the f

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Muñoz-Jordán, Jorge L., Maudry Laurent-Rolle, Joseph Ashour, et al. "Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses." Journal of Virology 79, no. 13 (2005): 8004–13. http://dx.doi.org/10.1128/jvi.79.13.8004-8013.2005.

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ABSTRACT Flaviviruses are insect-borne, positive-strand RNA viruses that have been disseminated worldwide. Their genome is translated into a polyprotein, which is subsequently cleaved by a combination of viral and host proteases to produce three structural proteins and seven nonstructural proteins. The nonstructural protein NS4B of dengue 2 virus partially blocks activation of STAT1 and interferon-stimulated response element (ISRE) promoters in cells stimulated with interferon (IFN). We have found that this function of NS4B is conserved in West Nile and yellow fever viruses. Deletion analysis

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Konan, Kouacou V., Thomas H. Giddings, Masanori Ikeda, Kui Li, Stanley M. Lemon, and Karla Kirkegaard. "Nonstructural Protein Precursor NS4A/B from Hepatitis C Virus Alters Function and Ultrastructure of Host Secretory Apparatus." Journal of Virology 77, no. 14 (2003): 7843–55. http://dx.doi.org/10.1128/jvi.77.14.7843-7855.2003.

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ABSTRACT The nonstructural proteins of hepatitis C virus (HCV) have been shown previously to localize to the endoplasmic reticulum (ER) when expressed singly or in the context of other HCV proteins. To determine whether the expression of HCV nonstructural proteins alters ER function, we tested the effect of expression of NS2/3/4A, NS4A, NS4B, NS4A/B, NS4B/5A, NS5A, and NS5B from genotype 1b HCV on anterograde traffic from the ER to the Golgi apparatus. Only the nominal precursor protein NS4A/B affected the rate of ER-to-Golgi traffic, slowing the rate of Golgi-specific modification of the vesi

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Roosendaal, Jojanneke, Edwin G. Westaway, Alexander Khromykh, and Jason M. Mackenzie. "Regulated Cleavages at the West Nile Virus NS4A-2K-NS4B Junctions Play a Major Role in Rearranging Cytoplasmic Membranes and Golgi Trafficking of the NS4A Protein." Journal of Virology 80, no. 9 (2006): 4623–32. http://dx.doi.org/10.1128/jvi.80.9.4623-4632.2006.

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ABSTRACT A common feature associated with the replication of most RNA viruses is the formation of a unique membrane environment encapsulating the viral replication complex. For their part, flaviviruses are no exception, whereupon infection causes a dramatic rearrangement and induction of unique membrane structures within the cytoplasm of infected cells. These virus-induced membranes, termed paracrystalline arrays, convoluted membranes, and vesicle packets, all appear to have specific functions during replication and are derived from different organelles within the host cell. The aim of this st

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Paredes, Anne M., and Keril J. Blight. "A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication." Journal of Virology 82, no. 21 (2008): 10671–83. http://dx.doi.org/10.1128/jvi.00875-08.

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ABSTRACT Hepatitis C virus (HCV) nonstructural protein 4B (NS4B), a poorly characterized integral membrane protein, is thought to function as a scaffold for replication complex assembly; however, functional interactions with the other HCV nonstructural proteins within this complex have not been defined. We report that a Con1 chimeric subgenomic replicon containing the NS4B gene from the closely related H77 isolate is defective for RNA replication in a transient assay, suggesting that H77 NS4B is unable to productively interact with the Con1 replication machinery. The H77 NS4B sequences that pr

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Koupriyanov, V. V., L. I. Nikolaeva, A. A. Zykova, et al. "IMMUNOGENIC PROPERTIES OF RECOMBINANT MOZAIC PROTEINS BASED ON ANTIGENS NS4A AND NS4B OF HEPATITIS C VIRUS." Problems of Virology, Russian journal 63, no. 3 (2018): 138–43. http://dx.doi.org/10.18821/0507-4088-2018-63-3-138-143.

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The aim of the study was to investigate immunogenic properties of mosaic recombinant proteins constructed on the data of hepatitis C virus NS4A and NS4B antigens. Four mosaic recombinant proteins, containing the T and B epitopes of the NS4A and NS4B antigens, were created by genetic engineering methods in the E. coli system. To enhance the immune response they were linked in different variations to the nucleotide sequences of murine interleukin-2 (IL-2), the Neisseria meningiditis lipopeptide, and the T helper epitope of the core protein of hepatitis C virus. The immunogenic properties of thes

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Stone, Michelle, Shuaizheng Jia, Won Do Heo, Tobias Meyer, and Kouacou V. Konan. "Participation of Rab5, an Early Endosome Protein, in Hepatitis C Virus RNA Replication Machinery." Journal of Virology 81, no. 9 (2007): 4551–63. http://dx.doi.org/10.1128/jvi.01366-06.

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ABSTRACT Like most positive-strand RNA viruses, hepatitis C virus (HCV) is believed to replicate its genome on the surface of rearranged membranes. We have shown previously that HCV NS4AB, but not the product NS4B, inhibits endoplasmic reticulum (ER)-to-Golgi protein traffic (K. V. Konan, T. H. Giddings, Jr., M. Ikeda, K. Li, S. M. Lemon, and K. Kirkegaard, J. Virol. 77:7843-7855). However, both NS4AB and NS4B can induce “membranous web” formation, first reported by Egger et al. (D. B Egger, R. Gosert, L. Bianchi, H. E. Blum, D. Moradpour, and K. Bienz, J. Virol. 76:5974-5984), which is also o

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Klaitong, Paeka, and Duncan R. Smith. "Roles of Non-Structural Protein 4A in Flavivirus Infection." Viruses 13, no. 10 (2021): 2077. http://dx.doi.org/10.3390/v13102077.

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Infections with viruses in the genus Flavivirus are a worldwide public health problem. These enveloped, positive sense single stranded RNA viruses use a small complement of only 10 encoded proteins and the RNA genome itself to remodel host cells to achieve conditions favoring viral replication. A consequence of the limited viral armamentarium is that each protein exerts multiple cellular effects, in addition to any direct role in viral replication. The viruses encode four non-structural (NS) small transmembrane proteins (NS2A, NS2B, NS4A and NS4B) which collectively remain rather poorly charac

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De Francesco, Raffaele, Antonello Pessi, and Christian Steinkühler. "The Hepatitis C Virus NS3 Proteinase: Structure and Function of a Zinc-Containing Serine Proteinase." Antiviral Therapy 3, no. 3_suppl (1998): 99–109. http://dx.doi.org/10.1177/135965359800303s01.

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The hepatitis C virus (HCV) NS3 protein contains a serine proteinase domain implicated in the maturation of the viral polyprotein. NS3 forms a stable heterodimer with NS4A, a viral memebrane protein that acts as an activator of the IMS3 proteinase. The three-dimensional structure of the NS3 proteinase complexed with an NS4A-derived peptide has been determined. The NS3 proteinase adopts a chymotrypsin-like fold. A β-strand contributed by NS4A is clamped between two β-strands within the N terminus of NS3. Consistent with the requirement for extraordinarily long peptide substrates (P6-P4’), the s

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Martin, Morgan M., Stephanie A. Condotta, Jeremy Fenn, Andrea D. Olmstead, and François Jean. "In-cell selectivity profiling of membrane-anchored and replicase-associated hepatitis C virus NS3-4A protease reveals a common, stringent substrate recognition profile." Biological Chemistry 392, no. 10 (2011): 927–35. http://dx.doi.org/10.1515/bc.2011.076.

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AbstractThe need to identify anti-Flaviviridaeagents has resulted in intensive biochemical study of recombinant nonstructural (NS) viral proteases; however, experimentation on viral protease-associated replication complexes in host cells is extremely challenging and therefore limited. It remains to be determined if membrane anchoring and/or association to replicase-membrane complexes of proteases, such as hepatitis C virus (HCV) NS3-4A, plays a regulatory role in the substrate selectivity of the protease. In this study, we examined trans-endoproteolytic cleavage activities of membrane-anchored

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Tesis sobre el tema "NS4B protein"

Meyer, Aline Katharina [Verfasser], and Christoph [Akademischer Betreuer] Sarrazin. "Bedeutung eines prädizierten Leuzinzippermotivs im NS4B-Protein des Hepatitis-C-Virus für NS4B-Proteininteraktionen / Aline Katharina Meyer. Betreuer: Christoph Sarrazin." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/105290498X/34.

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Lundin, Marika. "Topology and membrane rearrangements of the hepatitis C virus protein NS4B /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-927-0/.

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Gretton, Sarah N. "Topology and biophysical characterisation of the hepatitis C virus NS4B protein." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433078.

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Ismail, Rosmani. "Elucidation of the mechanism of action of a mutation in the dengue virus NS4B protein that confers a persistent phenotype in cell culture." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684745.

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Dengue viruses (DENVs) are mosquito-borne flaviviruses, which are responsible for a wide range of illnesses, from a mild febrile illness to the more serious dengue haemorrhagic fever and dengue shock syndromes. The DENV NS4B is a highly hydrophobic integral ER membrane protein that has been reported to perturb type I interferon (IFN) signalling and has emerged as a major target for anti-viral strategies. The objective of this study was to determine the mechanism of action of two consecutive nucleotide mutations in the NS4B gene (nt 7020 and 7021) that result in the substitution of threonine 66

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Lindström, Hannah Kim. "Molecular studies of the hepatitis C virus : the role of IRES activity for therapy response, and the impact of the non-structural protein NS4B on the viral proliferation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-875-4/.

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Machmouchi, Dana. "Exploring the Pathogenic Mechanisms of West African Zika Virus : viral Replication and Host Interaction." Electronic Thesis or Diss., La Réunion, 2024. https://elgebar.univ-reunion.fr/login?url=http://thesesenligne.univ.run/24_14_D_MACHMOUCHI.pdf.

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Le virus Zika (ZIKV), historiquement limité à l'Afrique et à l'Asie, est devenu une préoccupation mondiale majeure, surtout après les épidémies récentes dans les Amériques associées à des malformations congénitales graves et des troubles neurologiques. Bien que la recherche se soit principalement concentrée sur le génotype asiatique/américain, des preuves croissantes montrent que les souches africaines du ZIKV pourraient également représenter une menace sévère, notamment en termes de pathogénicité fœtale. Cette thèse vise à améliorer notre compréhension des mécanismes moléculaires de la pathog

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Zwart, Lizahn. "Investigating two AHSV non-structural proteins : tubule-forming protein NS1 and novel protein NS4." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/62198.

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African horse sickness is an equid disease caused by African horse sickness virus (AHSV). AHSV produces seven structural proteins that form the virion and four non-structural proteins with various roles during replication. The first part of this study investigated the intracellular distribution and co-localisations of NS1 with other AHSV proteins to facilitate its eventual functional characterisation. Confocal microscopy revealed that NS1 formed small cytoplasmic foci early after infection that gradually converged into large fluorescent NS1 tubule bundles. Tubule bundles were more organised in

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Taylor, Annette Irene. "The intracellular localisation and membrane-altering properties of hepititis C virus proteins NS4B and NS5A." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274768.

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Jin, Yi. "Characterisation of the African horse sickness virus NS4 protein." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8973/.

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African horse sickness is one of the most deadly infectious diseases of horses. The disease is caused by African horse sickness virus (AHSV), an arbovirus transmitted by culicoides midges. AHSV is classified within the genus Orbivirus, family Reovirdae. The AHSV genome is composed by ten segments of double stranded RNA (dsRNA) encoding seven structural and at least four non-structural (NS) proteins. AHSV shares structural and functional similarities with Bluetongue virus, the ‘prototype’ species of the genus Orbivirus. An alternative open reading frame (ORF), overlapping the main ORF encoding

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Choi, Yook-Wah. "Structural and functional characterization of human DDX5 and its interaction with NS5B of hepatitis C virus." University of the Western Cape, 2011. http://hdl.handle.net/11394/5299.

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Philosophiae Doctor - PhD<br>Hepatitis C was first recognized as a transfusion-associated liver disease not caused by hepatitis A or hepatitis B virus after serological tests were developed to screen for their presence in the blood. The infectious agent was finally identified with the cloning of the cDNA of hepatitis C virus (HCV) using random polymerase chain reaction (PCR) screening of nucleic acids extracted from plasma of a large pool of chimpanzee infected with non-A non-B hepatitis. NS5B, a membrane-associated RNA-dependent RNA polymerase essential in the replication of HCV, initiates

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Capítulos de libros sobre el tema "NS4B protein"

Rehman, Muneeb Ur, and Hafiz Zain Ul Abideen. "Molecular Basis of Hepatitis C." In Fundamentals of Cellular and Molecular Biology. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815238037124010018.

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Hepatitis C virus (HCV) is a significant cause of chronic liver disease worldwide. The molecular basis of HCV infection and replication has been extensively studied, leading to the identification of vital viral proteins and their interactions with host factors. The HCV genome encodes a single polyprotein cleaved by host and viral proteases into individual proteins, including the core, envelope glycoproteins (E1 and E2), p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B. These viral proteins play critical roles in virus assembly, entry, replication, and evasion of host immune responses. The HCV envelope

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Kantagba, Yves M. K., Seydou Golo Barro, Serge L. W. Nikiema, and Pascal Staccini. "In Silico Screening of Phytocompounds from West African Traditional Medicine and Molecular Docking Targeting Dengue Virus Protein NS2B/NS3." In Studies in Health Technology and Informatics. IOS Press, 2024. http://dx.doi.org/10.3233/shti240492.

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Traditional medicine offers a wide range of application for in silico study techniques. This drug research and development strategy is embryonic in the West African context, particularly in Burkina Faso, which is increasingly faced with emerging diseases such as dengue fever. Circulation of the 4 serotypes of this virus has been documented in the country. This study aims to evaluate the therapeutic potential of phytocompounds contained in the West African pharmacopoeia against dengue virus NS2B/NS3 protein, using computational methods integrating several software packages and databases. Based

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Yaro, Prof Abubakar, Dr Francis Ohanyido, and Prof Ashok Rattan. "DRUG RESISTANCE IN FOUR IMPORTANT HUMAN VIRUSES: UPDATED REVIEW." In Microbes of Medical Importance. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurmmch11.

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Viruses causes severe infections and associated and linked with outbreaks of some major global diseases such as HIV/AIDS, COVID-19, influenza virus, dengue fever, common cold, and hepatitis. The infective process of viruses varies depending on the viral species; however, they follow certain steps in the infective process. The typical stages in their life cycle include (Fig 1): attachment and entry, viral uncoating, replication and transcription of viral genome, protein synthesis, assembly, and release of progeny virus. Antiviral drugs are used in combating viral infections and the development

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Actas de conferencias sobre el tema "NS4B protein"

Ferreira da Silva, Giovanna, Marcello do Couto Dias, Irley Karoline Seixas Paiva, Mércia Ferreira Ribeiro, Katarine Antonia dos Santos Barile, and Carlos Eduardo de Melo Amaral. "AVALIAÇÃO DO TESTE SUPLEMENTAR GEENIUS HCV SUPPLEMENTAL ASSAY NA DISPARIDADE ENTRE RESULTADO DE TRIAGEM SOROLÓGICO-MOLECULAR PARA O VÍRUS DA HEPATITE C." In Congresso Brasileiro de Inovação em Microbiologia. Congresse.me, 2022. http://dx.doi.org/10.54265/rnfk1700.

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INTRODUÇÃO: A detecção de HCV na triagem, em doadores de sangue da Fundação Hemopa, é realizada simultaneamente por um teste sorológico e um teste molecular. No caso de discordância entre estes, é realizado um teste confirmatório. Geenius HCV Supplemental Assay é utilizado como teste confirmatório suplementar para análise da presença de anticorpos específicos para HCV, utilizando os antígenos específicos NS3, NS4, NS5 e capsídeo. OBJETIVO: Determinar a freqüência de resultado de imunocromatografia Geenius HCV Confirmatory Assay (BioRad) em amostras Eclesys Anti-HCV reagentes (positivos e incon

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