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Literatura académica sobre el tema "Radio pharmaceuticals"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 11 de febrero de 2022

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Artículos de revistas sobre el tema "Radio pharmaceuticals"

Khan, Rana, Aizaz Ahmed Khan, Nuha Rasheed y Abdul Saleem Mohammad. "Current Trends in Radio-Pharmaceuticals". Asian Journal of Pharmacy and Technology 7, n.º 2 (2017): 77. http://dx.doi.org/10.5958/2231-5713.2017.00012.5.

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Carlucci, Giuseppe, Hildo J.K. Ananias, Zilin Yu, Christophe Van de Wiele, Rudi A. Dierckx, Igle J. de Jong y Philip H. Elsinga. "Multimerization Improves Targeting of Peptide Radio-Pharmaceuticals". Current Pharmaceutical Design 18, n.º 17 (1 de abril de 2012): 2501–16. http://dx.doi.org/10.2174/13816128112092501.

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Shahzad, Khurram, Aman Shah Abdul Majid, Mumtaz Khan, Muhammad Adnan Iqbal y Asjad Ali. "Recent advances in the synthesis of (99mTechnetium) based radio-pharmaceuticals". Reviews in Inorganic Chemistry 41, n.º 3 (26 de enero de 2021): 151–98. http://dx.doi.org/10.1515/revic-2020-0021.

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Abstract Technetium radionuclide (99mTc) has excellent extent of disintegration properties and occupies a special place in the field of nuclear medicinal chemistry and other health disciplines. Current review describes recent approaches of synthesis in detailed ways for radio-pharmaceuticals of technetium which have been developed to treat and diagnose the biotic disorders. These technetium labeled radio-pharmaceuticals have been established to apply in the field of diagnostic nuclear medicine especially for imaging of different body parts such as brain, heart, kidney, bones and so on, through single photon emission computed tomography (SPECT) that is thought to be difficult to image such organs by using common X-ray and MRI (Magnetic Resonance Imaging) techniques. This review highlights and accounts an inclusive study on the various synthetic routes of technetium labeled radio-pharmaceuticals using ligands with various donor atoms such as carbon, nitrogen, sulphur, phosphorus etc. These compounds can be utilized as next generation radio-pharmaceuticals.

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Zimmer, Luc. "Pharmacological agonists for more-targeted CNS radio-pharmaceuticals". Oncotarget 7, n.º 49 (16 de noviembre de 2016): 80111–12. http://dx.doi.org/10.18632/oncotarget.13418.

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Theobald, A. "Labelled compounds and radio-pharmaceuticals applied in nuclear medicine". Endeavour 11, n.º 4 (enero de 1987): 220–21. http://dx.doi.org/10.1016/0160-9327(87)90312-7.

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Isabelle, D. B. y J. Vernois. "Labelled compounds and radio-pharmaceuticals applied in nuclear medicine". Biochimie 69, n.º 11-12 (noviembre de 1987): 1263. http://dx.doi.org/10.1016/0300-9084(87)90161-1.

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Ismailani, Uzair S., Maxime Munch, Braeden A. Mair y Benjamin H. Rotstein. "Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C–carbonyls". Chemical Communications 57, n.º 43 (2021): 5266–69. http://dx.doi.org/10.1039/d1cc01016f.

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Turck, R. "Radio-pharmaceuticals for cancer treatment: are they ready for prime time yet?" Annals of Oncology 29, n.º 7 (julio de 2018): 1594–97. http://dx.doi.org/10.1093/annonc/mdy142.

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Ludwig, Dale, Ruth Bryan, Wojciech Dawicki, Eileen M. Geoghegan, Qing Liang, Sandesh Seth, Mamata Gokhale et al. "Preclinical Development of an Actinium-225-Labeled Antibody Radio-Conjugate Directed Against CD45 for Targeted Conditioning and Radioimmunotherapy". Blood 134, Supplement_1 (13 de noviembre de 2019): 5601. http://dx.doi.org/10.1182/blood-2019-128678.

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Introduction: Radiolabeled CD45 antibodies have demonstrated clinical promise as targeted conditioning treatments prior to bone marrow transplant (BMT) as a better tolerated and potentially more effective alternative to harsh chemotherapy and/or total body irradiation regimens for myeloablative conditioning. CD45 is expressed on all immune cells, including hematopoietic stem cells and both precursor and mature lymphoid and myeloid cells, with an average copy number up to 200,000 molecules per cell, making it an ideal antigen for directing targeted radiation for conditioning. It is also highly expressed on most lymphomas and leukemias, and approximately 50% of multiple myeloma, further offering the potential for mediating a substantial anti-tumor effect in treated patients. We describe the preclinical development of a novel anti-CD45 antibody radio-conjugate (ARC) that harnesses the power of alpha radiation by arming the pan-CD45 antibody BC8 with Actinium-225 (225Ac). 225Ac is a potent radionuclide with high linear energy transfer (80-100 keV/μm) yet short path length (50-80 μm) to deliver significantly more lethal double strand DNA breaks per alpha track than beta particles. In addition, the use of 225Ac for targeted conditioning has advantages of safe handling and ease of use and a long 10 day half-life that enables flexibility in preparation and use. Methods and Results: To generate 225Ac-BC8, the monoclonal antibody was first conjugated with the DOTA chelator, then labeled with 225Ac, achieving a labeling efficiency typically greater than 80%. 225Ac-BC8 was subsequently purified to high radiochemical purity by column chromatography. Using human CD45+ Ramos lymphoma cell line and EL4 as negative control, 225Ac-BC8 was shown to be stable and retain selective immunoreactivity following conjugation and labeling. To evaluate the anti-tumor potency of 225Ac-BC8, two CD45+ human multiple myeloma (MM) cell lines with high or low relative CD45 antigen density, U266 and H929, respectively, (Collette, et al. 2007) were tested by cell cytotoxicity assay. Following transient exposure (4 or 12 hours) to 225Ac-BC8, the ARC demonstrated potent dose-dependent MM cell killing 72 hours post-treatment, achieving greater than 90% cytotoxicity of both cell lines. To further assess the therapeutic potential of 225Ac-BC8, its anti-tumor activity was tested in subcutaneous (s.c.) xenograft models of H929 and U266. NOD-SCID mice bearing established s.c. tumors were randomized to receive a single dose of 300 nCi of 225Ac-BC8, 300 nCi of an irrelevant radio-conjugate 225Ac-18B7, naked BC8 antibody, or no treatment control. In both models, 225Ac-BC8 exerted complete and durable tumor control for the duration of study. None of the control groups exhibited any anti-tumor effect. Studies to evaluate 225Ac-BC8 in models of CD45+ lymphoma are ongoing. Since BC8 does not cross-react with mouse CD45 and only weakly with macaque CD45, biodistribution, dosimetry and imaging analysis was performed in mice using radio-labeled anti-mouse pan-CD45 surrogate antibody 30F11. SPECT/CT imaging and biodistribution was performed with 111In-labeled 30F11. Following IV administration, 111In-CD45 (30F11) rapidly cleared from the blood and accumulated in immune system organs including spleen, bone marrow, and lymph node. Dosimetry calculations for 225Ac-CD45 (30F11) were determined for absorbed dose to target organs. Only modest uptake was noted in the kidney, but significant uptake occurred in liver, the major site for catabolism of full-length antibodies. 225Ac-CD45 (30F11) is a useful molecule to study the tolerability and myeloablative properties of 225Ac-CD45 antibody for targeted conditioning prior to donor BMT, using B6-Ly5b donor cells in B6-Ly5a mice. Results of ongoing studies will also be presented. Conclusions: The pan-CD45 antibody BC8 was shown to be efficiently conjugated and labeled with the potent alpha emitter 225Ac to mediate robust and selective killing of CD45+ MM cells and xenografts. Biodistribution analysis confirmed selective uptake into organs of the immune system including homing to BM. Supported by ongoing myeloablative/BM reconstitution studies, these preclinical data support the development of 225Ac-BC8 as a novel potent and safe targeted conditioning approach for BMT. Reference: Collette, et al., (2007). Eur. Cytokine Netw. 18:120-126. Disclosures Ludwig: Actinium Pharmaceuticals: Employment, Equity Ownership. Dawicki:Actinium Pharmaceuticals: Research Funding. Geoghegan:Actinium Pharmaceuticals: Employment. Liang:Actinium Pharmaceuticals: Employment. Seth:Actinium Pharmaceuticals: Employment, Equity Ownership. Gokhale:Actinium Pharmaceuticals: Employment. Berger:Actinium Pharmaceuticals, Inc: Employment, Equity Ownership. Reddy:Actinium Pharmaceuticals: Employment. Dadachova:Actinium Pharmaceuticals: Consultancy, Research Funding; RadImmune Therapeutics: Consultancy, Research Funding.

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Zimmerman, Chris. "Protecting the Pharmaceutical Supply Channel". Journal of Pharmacy Practice 19, n.º 4 (agosto de 2006): 236–38. http://dx.doi.org/10.1177/0897190006293516.

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Protecting and securing the pharmaceutical supply channel requires constant vigilance in cooperation with all partners in the channel: the manufacturer, the distributor, and the pharmacy as well as state and federal legislators and regulatory agencies. No one approach can protect and secure; rather, the pharmaceutical industry as a whole needs to adopt a combination of approaches to ensure the safety and integrity of the supply channel. Right now, the most secure way to ensure product integrity and patient safety is through a primary distribution system, also referred to as normal distribution. Primary distribution involves the movement of pharmaceuticals from the manufacturer to the wholesale distributor to the pharmacy. Going forward, some new technologies offer great promise. The industry needs to address all technology solutions, from secure product packaging to tracking techniques such as tags, holograms, and ultimately radio frequency identification. All of these begin with the manufacturer, require wholesaler involvement, and rely on the pharmacy. The movement of product must be secure and the highest level of vigilance maintained.

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Tesis sobre el tema "Radio pharmaceuticals"

Gangadeen, Kevin E. y Bernadette D. Houston. "Assessing industry business practices in implementing Radio Frequency Identification (RFID) in the tracking and tracing of pharmaceuticals". Monterey, California. Naval Postgraduate School, 2005. http://hdl.handle.net/10945/9976.

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MBA Professional Report
The purpose of this MBA project is to assess industry business practices in implementing RFID technology in the tracking and tracing of pharmaceuticals. Our project will focus on what was found during our research (to include interviews and site visits) which was quite different from what was portrayed by the media. Our analysis of a few organizations will identify what market leaders do when considering the implementation of a new technology into its business practices. Based on our analysis, we determined what patterns were common throughout the industry and what DoD should be aware of as it implements RFID technology in the tracking and tracing of pharmaceuticals.

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Qin, Zhifeng y 秦志锋. "RFID-enabled life-cycle traceability in pharmaceutical supply chain". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46975068.

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Niese, Siegfried. "Verflechtung von Wissenschaft und Produktion im Zentralinstitut für Kernforschung Rossendorf (1958 bis 1991)". Gesellschaft Deutscher Chemiker, 2012. https://slub.qucosa.de/id/qucosa%3A2833.

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Die Produktion von Radiopharmaka im Zentralinstitut für Kernforschung Rossendorf (ZfK) von 1958-1991 ist ein Beispiel für eine enge Kooperation von interdisziplinärer Forschung und Produktion mit hervorragenden Möglichkeiten für den Austausch von Personal und Erfahrungen. Für das kurzlebige 99Tc, das zu ungefähr 90% in der nuklearmedizinischen Diagnostik eingesetzt wird, erfolgte der gesamte Prozess von der Bestrahlung von angereichertem U, chemischer Abtrennung des langlebigen Mutternuklids 99Mo bis zur Herstellung von Tc-Gerneratoren im Institut. Das ZfK gehörte weltweit zu den wichtigsten Produzenten von Radiopharmaka. Im Jahr 1972 wurde von der Regierung die Überführung der Produktion aus dem Institut in einen pharmazeutischen Betrieb zur Diskussion gestellt, aber aus wirtschaftlichen Gründen nicht durchgeführt.
The production of radio pharmaceuticals in the Nuclear Research Center Rossendorf (NRCR) from 1958 to 1991 is an example for a close cooperation of interdisciplinary research and fabrication with outstanding possibilities for the exchange of personal and experiences. For the short lived 99mTc, which is used in about 90% of the diagnosis in nuclear medicine, the whole process from irradiation of enriched U, chemical isolation of the longer lived mother nuclide 99Mo and the production of the Tc-generators were done in the institute. The NRCR was one of the most important producers of radio pharmaceuticals worldwide until 1991. In 1972 the government considered transforming of the fabrication from the institute to a pharmaceutical enterprise, but it has been not realized for economic reasons.

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Niese, Siegfried. "Verflechtung von Wissenschaft und Produktion im Zentralinstitut für Kernforschung Rossendorf (1958 bis 1991)". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-104579.

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Die Produktion von Radiopharmaka im Zentralinstitut für Kernforschung Rossendorf (ZfK) von 1958-1991 ist ein Beispiel für eine enge Kooperation von interdisziplinärer Forschung und Produktion mit hervorragenden Möglichkeiten für den Austausch von Personal und Erfahrungen. Für das kurzlebige 99Tc, das zu ungefähr 90% in der nuklearmedizinischen Diagnostik eingesetzt wird, erfolgte der gesamte Prozess von der Bestrahlung von angereichertem U, chemischer Abtrennung des langlebigen Mutternuklids 99Mo bis zur Herstellung von Tc-Gerneratoren im Institut. Das ZfK gehörte weltweit zu den wichtigsten Produzenten von Radiopharmaka. Im Jahr 1972 wurde von der Regierung die Überführung der Produktion aus dem Institut in einen pharmazeutischen Betrieb zur Diskussion gestellt, aber aus wirtschaftlichen Gründen nicht durchgeführt
The production of radio pharmaceuticals in the Nuclear Research Center Rossendorf (NRCR) from 1958 to 1991 is an example for a close cooperation of interdisciplinary research and fabrication with outstanding possibilities for the exchange of personal and experiences. For the short lived 99mTc, which is used in about 90% of the diagnosis in nuclear medicine, the whole process from irradiation of enriched U, chemical isolation of the longer lived mother nuclide 99Mo and the production of the Tc-generators were done in the institute. The NRCR was one of the most important producers of radio pharmaceuticals worldwide until 1991. In 1972 the government considered transforming of the fabrication from the institute to a pharmaceutical enterprise, but it has been not realized for economic reasons

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Charneca, Diogo Fernando Aurélio Semião. "Operating profitability in branded pharmaceutical firms". Master's thesis, NSBE - UNL, 2013. http://hdl.handle.net/10362/11612.

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A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA – School of Business and Economics
This work project focuses in operating profitability of branded pharmaceuticals, measured by return on assets (ROA). It gives insights about key ROA drivers, by breaking down this ratio into gross sales margin, assets turnover and operating risk. Data from consolidated financial statements of 26 US- and European-based firms for the period 2007-2011 is used in univariate and bivariate analyses. Results suggested that firm size and country-membership do not significantly correlate with ROA. However, differences between branded pharmaceuticals’ regions are explored and significant correlations are found between operating profitability and strategic choices variables, namely product portfolio diversification, growth choices and investment.

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Faruk, Hossan y Ahsan Habib. "Performance evaluation and ratio analysis of Pharmaceutical Company in Bangladesh". Thesis, University West, Department of Economics and Informatics, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-2516.

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The thesis applies performance evaluation of pharmaceutical company in Bangladesh. It means evaluate how well the company performs. The main aim is achieved through ratio analysis of two pharmaceutical (Beximco and Square pharmaceutical) companies in Bangladesh. The main data collection from the annual financial reports on Beximco and square pharmaceutical companies in 2007 to 2008.Different financial ratio are evaluated such liquidity ratios, asset management ratios, profitability ratios, market value ratios, debt management ratios and finally measure the best performance between two companies. The mathematical calculation was establish for ratio analysis between two companies from 2007-2008.It is most important factors for performance evaluation. The graphical analysis and comparisons are applies between two companies for measurement of all types of financial ratio analysis. Liquidity ratio is conveying the ability to repay short-term creditors and it total cash. It determines perform of short term creditor of both pharmaceutical companies under the three categories such as current ratio, quick ratio and cash ratio. Asset management ratio is measurement how to effectively a company to use and controls its assets. Its also quantify into seven categories for both pharmaceutical companies such as account receivable turnover, average collection period, inventory turnover, account payable turnover ,account payable turnover in days ,fixed asset turnover ,total asset turnover. Profitability ratio is evaluate how well a company is performing by analyzing and how profit was earned relative to sales, total assets and net worth for both pharmaceutical companies. Debt coverage ratio is performing that the property insufficient to collect their mortgage for both companies and market value is perform the stockholder to analysis their future market value of the stock market. Overall analyses are measurement the best one between Beximco and Square pharmaceutical companies.

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Duncan, Andrew Jacob Edward. "Explorations in crystal engineering : supramolecular templates, helical assemblies, pharmaceutical reactivity, and applications to radio-imaging". Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5931.

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Crystal engineering is a rapidly developing area of research with goals aimed at designing molecular solids with desired physical and chemical properties. By utilizing reliable intermolecular interactions, the principles of supramolecular chemistry are exploited in the solid state in order to achieve favorable arrangements of molecules in a crystal lattice. We have applied crystal engineering strategies to further develop the strategy of template-directed reactivity in the solid state. An evaluation of catechol, a regioisomer of the commonly used resorcinol template, was performed. Co-crystallization of the template candidate with a bis-pyridyl olefin produced a discrete self-assembled architecture wherein hydrogen-bonded dimers of catechol pre-organize the olefins for a [2+2] photodimerization in the solid state. The dimerization was determined to proceed quantitatively and X-ray studies of a partial single-crystal-to-single-crystal reaction supported the hypothesis of the reaction proceeding exclusively within the discrete assemblies, despite the infinite stacking of the olefins. A study of substituent effects on the conformational bias of additional catechol- based template candidates was carried out. Candidates with bulky substituents a the 3- and 4-positions were observed to adopt a favorable syn-anti or syn-gauche conformer in most cases. Though conformational bias was induced and discrete assembly achieved, only one of the synthesized cocrystals met the geometric requirements for a photodimerization, however, extended UV exposure produced no evidence of product formation. We discuss the fortuitous discovery of a catechol-based cocrystal system that produces an infinite linear assembly. The fluorine atom of 3-fluorocatechol was observed to be too small to induce conformational bias in the template candidate. However, the system was observed to progress through a three-step solvent-mediated phase transformation. The second and third crystal phases were isolated and characterized by single-crystal X-ray diffraction. The X-ray data revealed that the zig-zag assembly of the first phase spontaneously transforms to a double helix topology in the second phase, before transforming to the final phase, which exhibits a quadruple helix topology. In our studies of pharmaceutical cocrystals, we sought to perform a systematic study of the solid-state behavior of the anti-cancer drug 5-fluorouracil. Inspired by previously published cocrystal structures, we performed co-crystallization experiments with a small series of structurally similar coformers. Comparison of the three structures revealed an inconsistent degree of synthon disruption between the coformers. Curiously, one of the cocrystals obtained displayed a packing arrangement consistent with the requirements of a [2+2] cycloaddition. Irradiation of the sample with UV light resulted in the quantitative formation of a cross-photocycloaddition product. The product was characterized as a pyrimidine-fused cyclobutane, the first reported synthetic derivative of 5-fluorouracil obtained from a solid-state reaction. Lastly, we utilize crystal engineering strategies to study the behavior of 2- iodohippuric acid, a common radio-imaging target. The pharmacokinetic properties of 2- iodohippuric acid make it an ideal target for renal imaging. We sought to approach a solid formulation of the target in a similar manner to that of a drug or other metabolized pharmaceutical. In doing so, we hoped to study the compound’s behavior in the solid state so that we may eventually use co-crystallization as a means of altering the properties of the target for the purpose of generalizing its use in imaging the body.

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Rabali, Ridovhusanae. "Availability of registered pharmaceutical structures in South Africa : 2003 until 2008 / Ridovhusanae Rabali". Thesis, North-West University, 2009. http://hdl.handle.net/10394/4271.

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Despite the deteriorated state of health care in South Africa, the government remains committed to realising the right of every citizen to access health care, including good, quality and essential drugs. In recognising the availability of pharmaceutical facilities as a major component of access to health care, and the previous imbalances in the distribution of pharmaceutical structures and services, laws pertaining to the licensing and ownership of pharmacies were amended and promulgated in 2003 to address the distribution problem. In addition, regulations relating to a transparent priCing system on medicines and related sUbstances were introduced in 2004. These, coupled with factors influencing the choice of a pharmacy location, and the deficiencies in human resourges exercising an impact on both pharmacy and other health care personnel, have influenced the distribution and availability of pharmaceutical structures in South Africa from the year 2003 to 2008. OBJECTIVE: The main objective of this study was to investigate the availability and distribution of pharmaceutical structures registered with the South African Pharmacy Council, in South Africa, as of 2003 until 2008. METHOD: Data on the total number and geographical distribution of registered pharmaceutical structures in South Africa were obtained from the South African Pharmacy Council's register of pharmacies of August 2003, 2004, 2005, 2006, 2007 and 2008. The registered pharmaceutical structures were categorised according to their nature of services to the patient into "direct service" and "indirect service" (support) pharmacies. Availability was taken to refer to the actual presence of the pharmaceutical structures in relation to the demand for the services and measured quantitatively using population: provider ratios. The 'population' for indirect service pharmacies was taken as the direct service pharmacies and, the 'population' for direct seNice pharmacies was taken as the estimated population of the different geographical regions. RESULTS: The results revealed a 12% increase in the total number of registered pharmaceutical structures between the study years, to a total of 4227 pharmaceu'tical structures in 2008. Gauteng was identified as the province with the highest number of registered pharmaceutical structures, while the Northern Cape province contained the lowest number of registered pharmaceutical structures throughout the entire study period. The percentage of municipalities without any registered pharmaceutical structures decreased from 23% in 2003 to 19% in 2008. The indirect seNice pharmacies constituted 14% of the total number of registered pharmaceutical structures in South Africa. Most of these structures were situated in the province of Gauteng throughout the study period. National availability of these structures only improved for the manufacturing pharmacies. The registered direct seNice pharmacies increased by 13.2% to total 3642 pharmacies in 2008. Approximately 20% of the municipalities in the country (respectively 5.5% of the population) did not contain any registered direct seNice pharmacy in 2008. Most of these municipalities were situated in the KwaZulu-Natal province. The province of Gauteng contained the highest proportion (32%) of the direct seNice pharmaceutical structures. The decrease in the pharmacy per population ratio of the structures from 1: 14 547 people in 2003 to 1: 13 615 people in 2008 indicated an improvement in the availability of the structures. However, the improved availability did not take effect within each province as the Northern Cape, Mpumalanga and Gauteng provinces experienced an increase in the pharmacy per population ratio. CONCLUSION: The availability of registered pharmaceutical structures in South Africa improved between 2003 and 2008. However, the distribution of these structures remains geographically uneven and inequitable to the population of the country.
Thesis (M.Pharm. (Pharmacy Practice))--North-West University, Potchefstroom Campus, 2010.

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Carlson, Paul Albin. "Lipid high-axial-ratio microstructures as pharmaceutical delivery systems : a physical characterization of the mechanisms behind drug release /". Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8111.

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Horsten, Sharon. "The impact of competition on the product-market strategies of entities in the pharmaceutical industry / Sharon Horsten". Thesis, North-West University, 2004. http://hdl.handle.net/10394/549.

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There can be little doubt that competition in the pharmaceutical industry has increased considerably over the past few years. Growth in the pharmaceutical industry in South Africa has been affected adversely in recent years by the increased competition from generic drug manufacturers. As soon as a drug comes off patent, competitors are ready with generic copies, resulting in price drops. Pharmaceutical companies are therefore forced to continually evaluate their existing strategies, to ensure that their financial performance remains at the desired level. This study aims to determine the importance that entities in the pharmaceutical industry attach to competition during the strategy-formulation process. The study will also attempt to provide an understanding of how entities have adapted their product-market strategies, as identified by Ansoff, over the past five years. As an ancillary objective, this research aims to determine whether the level of competition in the industry has adversely affected the financial performance of the entities competing within the industry. Entities within the pharmaceutical industry consider the level of competition in the industry to be very high, and, accordingly, it is one of the major factors that they consider when determining which product market strategy to adopt. Because of this, the product-market strategies adopted by entities in the pharmaceutical industry have changed substantially over the past five years. No strategy is, however, dominant. Over the past five years, most of the entities in the pharmaceutical industry have displayed improved profitability, risk and cash flow-ratios, as well as growth in revenue, net profit and net asset value. This improvement in financial performance is despite an increased level of competition. It can therefore be concluded that the level of competition in the pharmaceutical industry is not reflected directly in the overall financial performance of companies in the industry.
Thesis (M.Com. (Management Accounting))--North-West University, Potchefstroom Campus, 2005.

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Libros sobre el tema "Radio pharmaceuticals"

COENEN, HEINZ H., JOHN MERTENS y BERNARD MAZIEÈRE, eds. RADIOIONIDATION REACTIONS FOR RADIO PHARMACEUTICALS. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/1-4020-4561-1.

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Calculate with confidence. 4^a ed. St. Louis: Mosby, 2006.

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Calculate with confidence. 5^a ed. St. Louis, Mo: Mosby/Elsevier, 2010.

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M, Mulholland Joyce, ed. Drug calculations: Ratio and proportion problems for clinical practice. 9^a ed. St. Louis, Mo: Elsevier/Mosby, 2012.

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Ansheles y Sergienko. Radio nuclide diagnostics with neyrotropny pharmaceuticals. Infra-M Academic Publishing House, 2013. http://dx.doi.org/10.12737/1402.

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Wiffen, Philip, Marc Mitchell, Melanie Snelling y Nicola Stoner. Pharmaceutical calculations. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199603640.003.0012.

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Concentrations 236Moles and millimoles 238Practical issues involving pharmaceutical calculations 240Pharmaceutical calculations involving drug administration 242Pharmaceutical preparations consist of a number of different ingredients in a vehicle. The ingredients can be solid, liquid, or gas.‘Concentration’ is an expression of the ratio of the amount of an ingredient to the amount of product. Concentrations can be expressed in several ways. ...

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Capítulos de libros sobre el tema "Radio pharmaceuticals"

Slosman, Daniel O. y Pierre J. Magistretti. "Cerebral Spect Imaging: Advances in Radio Pharmaceuticals and Quantitative Analysis". En Alzheimer Disease, 445–50. Boston, MA: Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-4116-4_68.

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Nahler, Gerhard. "hazard ratio". En Dictionary of Pharmaceutical Medicine, 84. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_631.

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Nahler, Gerhard. "odds ratio". En Dictionary of Pharmaceutical Medicine, 125. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_953.

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Pedemonte, Stefano, M. Jorge Cardoso, Simon Arridge, Brian F. Hutton y Sebastien Ourselin. "Steady-State Model of the Radio-Pharmaceutical Uptake for MR-PET". En Medical Image Computing and Computer-Assisted Intervention – MICCAI 2012, 289–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-33415-3_36.

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Remaud, Gérald S. y Serge Akoka. "Isotope Ratio Monitoring by NMR. Part 3: New Applications for Traceability of Active Pharmaceutical Ingredients". En Modern Magnetic Resonance, 1–19. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-28275-6_128-1.

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Remaud, Gérald S. y Serge Akoka. "Isotope Ratio Monitoring by NMR: Part 3 – New Applications for Traceability of Active Pharmaceutical Ingredients". En Modern Magnetic Resonance, 2233–51. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-28388-3_128.

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Wyld, David C. "RFID Tagging of Pharmaceuticals". En Encyclopedia of Healthcare Information Systems, 1199–209. IGI Global, 2008. http://dx.doi.org/10.4018/978-1-59904-889-5.ch150.

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Resumen

Pharmaceuticals play a more prominent role in American health care than in any other nation. The North American market today comprises 47% of the global prescription drug market, which now exceeds half a trillion dollars, with Americans spending approximately $251.8 billion annually on pharmaceuticals. This is up significantly from a decade earlier, when American consumption represented approximately one-third of the world market (IMS Health, 2006a). America’s insatiable demand for prescription drugs has led to serious cracks in the drug supply chain of the world’s leading pharmaceutical market. This chapter examines the size and scope of the problem of counterfeit pharmaceuticals, both globally and in the United States. It looks at the impact this crisis is having both on public health and the pharmaceutical industry. Today, leaders in both the pharmaceutical industry and government are looking to more stringent regulations and radio frequency identification (RFID) tagging of pharmaceuticals as a way to head off the problems associated with an increasingly leaky drug supply chain. This chapter outlines the steps being taken in the United States to help secure this vital supply chain. Finally, an analysis is given of the impact the shift to electronic pedigrees of pharmaceuticals will have both on the pharmaceutical and RFID market spaces.

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"Introduction". En RADIOIONIDATION REACTIONS FOR RADIO PHARMACEUTICALS, 1–4. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/1-4020-4561-1_1.

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"Iodine Radionuclides". En RADIOIONIDATION REACTIONS FOR RADIO PHARMACEUTICALS, 5–16. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/1-4020-4561-1_2.

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"Iodinated Radiopharmaceuticals". En RADIOIONIDATION REACTIONS FOR RADIO PHARMACEUTICALS, 17–28. Dordrecht: Springer Netherlands, 2006. http://dx.doi.org/10.1007/1-4020-4561-1_3.

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Actas de conferencias sobre el tema "Radio pharmaceuticals"

Othman, M. A., M. Z. A. A. Aziz y M. Sinnappa. "The exposure of Radio Frequency (RF) radiation on pharmaceuticals medicine for RF application". En 2012 IEEE Symposium on Business, Engineering and Industrial Applications (ISBEIA). IEEE, 2012. http://dx.doi.org/10.1109/isbeia.2012.6422917.

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Uysal, Ismail, Price William DeHay, Erdem Altunbas, Jean-Pierre Emond, R. Scott Rasmussen y David Ulrich. "Non-thermal effects of radio frequency exposure on biologic pharmaceuticals for RFID applications". En 2010 IEEE International Conference on RFID (IEEE RFID 2010). IEEE, 2010. http://dx.doi.org/10.1109/rfid.2010.5467274.

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Cox, Felicia C. A. I., Vikas K. Sharma, Alexander M. Klibanov, Bae-Ian Wu, Jin A. Kong y Daniel W. Engels. "A Method to Investigate Non-Thermal Effects of Radio Frequency Radiation on Pharmaceuticals with Relevance to RFID Technology". En Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.259691.

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Gusmayadi, Inding y Priyanto. "The Effect of Concentration Ratio of Gelatine and Polyvinylpyrrolidone as Binders on the Physical Properties of Red Ginger (Zingiber officinale Rosc.) Extract Lozenges". En 1st Muhammadiyah International Conference on Health and Pharmaceutical Development. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008240901470153.

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Silva, Pablo Ignacio Marambio, Mãrcio Nannini S. Florêncio, Adicinéia A. de Oliveira y Rogério P. C. do Nascimento. "A bibliometric approach to the use of radio frequency identification (RFID) in the pharmaceutical supply chain". En EATIS 2020: 10th Euro American Conference on Telematics and Information Systems. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3401895.3402088.

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Wartono, Tri, Muliahadi Tumanggor, Bulan Oktrima y Veta Pasaribu. "Analysis of Ratio and Financial Performance of Open Company Pharmaceutical Industry Which has Been Listing in Indonesia Stock Exchange (Case Study in Pharmaceutical Company PT. Kimia Farma.Tbk)". En Proceedings of the 1st International Conference on Economics Engineering and Social Science, InCEESS 2020, 17-18 July, Bekasi, Indonesia. EAI, 2021. http://dx.doi.org/10.4108/eai.17-7-2020.2303065.

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Novikov, Sergey G., Viktor V. Prikhodko, Artyom B. Muralev, Alexey V. Berentsev, Aleksandr S. Alekseyev, Vyacheslav V. Svetukhin, Andrey V. Zhukov et al. "Hardware and software complex for storing record and data analysis of the technological process of production of radio pharmaceutical lutetium trichloride-based preparations". En INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING 2018 (ICCMSE 2018). Author(s), 2018. http://dx.doi.org/10.1063/1.5079213.

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McGlothlin, J., L. Slivovsky y J. Roggenbauer. "42. Development And Use Of A Radio-Telemetry Video Exposure Monitoring System To Identify And Control Airborne Particulate Exposures In A Pharmaceutical Manufacturing Facility". En AIHce 2002. AIHA, 2002. http://dx.doi.org/10.3320/1.2766379.

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Agarwal, Gaurav, VC Ramya, Sabaretnam Mayilvahanan, Gyan Chand, Anjali Mishra, Amit Agarwal, Saroj K. Mishra et al. "Abstract P4-02-02: Low-cost fluorescein guided sentinel lymph node biopsy as an alternative to radio-pharmaceutical guided SLNB -Results of a prospective, comparative validation study". En Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p4-02-02.

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Informes sobre el tema "Radio pharmaceuticals"

Gangadeen, Kevin E. y Bernadette D. Houston. Assessing Industry Business Practices in Implementing Radio Frequency Identification (RFID) in the Tracking and Tracing of Pharmaceuticals. Fort Belvoir, VA: Defense Technical Information Center, diciembre de 2005. http://dx.doi.org/10.21236/ada443412.

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