Bibliografías temáticas / Tertiary lymphoid structure

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Literatura académica sobre el tema "Tertiary lymphoid structure"

Autor: Grafiati
Publicado: 30 de noviembre de 2024
Última modificación: 31 de julio de 2025

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Artículos de revistas sobre el tema "Tertiary lymphoid structure"

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Cook, Seungho, Haenara Shin, Mi-Kyoung Seo, Dae Seung Lee, and Hongyoon Choi. "Abstract 5420: Deep learning-based mapping of tertiary lymphoid structure scores from H&E images of renal cell carcinoma trained by spatial transcriptomics data." Cancer Research 83, no. 7_Supplement (2023): 5420. http://dx.doi.org/10.1158/1538-7445.am2023-5420.

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Abstract Purpose Tertiary lymphoid structures are organized aggregates of immune cells present in the tumor microenvironment (TME) in which novel targets as well as beneficial biomarkers for immunotherapy in cancer were found. Here, we have developed and validated a deep learning model by integrating H&E images of renal cell carcinoma and spatial transcriptomics data to infer spatial mapping of tertiary lymphoid structure scores in TME only using hematoxylin and eosin (H&E) images. Methods A total of 20 H&E images combined with spatial transcriptomics data of renal cell carcinoma w
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Rustamkhanov, R. A., K. Sh Gantsev, and D. S. Tursumetov. "Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review)." Creative surgery and oncology 9, no. 4 (2020): 293–96. http://dx.doi.org/10.24060/2076-3093-2019-9-4-293-296.

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This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their role in the progression of the pathological process or resolution of a disease. The data presented in some research works confirms the relationship between the presence of tumour-specific (tumour-associated) tertiary lymphoid structures and a favourable prognosis in patients with various oncological diseases, which suggests the participation of
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Robles, Marcel R., Michael Malkowski, and Sandeep Krishnan. "S1842 Tertiary Lymphoid Structure Mimicking Pancreatic Mass." American Journal of Gastroenterology 117, no. 10S (2022): e1285-e1286. http://dx.doi.org/10.14309/01.ajg.0000864008.96774.a4.

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Evans, Isabel, and Mi-Yeon Kim. "Involvement of lymphoid inducer cells in the development of secondary and tertiary lymphoid structure." BMB Reports 42, no. 4 (2009): 189–93. http://dx.doi.org/10.5483/bmbrep.2009.42.4.189.

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Amwas, Nour, Darya Alizadeh, Christine Brown, et al. "Abstract A038: Inducing tumor associated tertiary lymphoid structures using cellular therapy." Cancer Immunology Research 13, no. 2_Supplement (2025): A038. https://doi.org/10.1158/2326-6074.io2025-a038.

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Abstract Targeting the tumor microenvironment (TME) to be more immune permissive is a potential strategy for enhancing immunotherapies, such as chimeric antigen receptor T cell (CAR-T) therapy, providing a promising avenue for treating aggressive tumors such as glioblastoma multiforme (GBM). Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that arise in response to chronic inflammation and mimic the structure and function of secondary lymphoid organs. The spontaneous presence of TLS in some solid tumors, including GBM, is associated with improved clinical outcome and responsi
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Zhou, Xingwang, Wenyan Li, Jie Yang, et al. "Tertiary lymphoid structure stratifies glioma into three distinct tumor subtypes." Aging 13, no. 24 (2021): 26063–94. http://dx.doi.org/10.18632/aging.203798.

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Gorecki, Grace, Lan Gardner Coffman, Sarah E. Taylor, and Tullia C. Bruno. "Tertiary lymphoid structure prevalence and prognostic value in cervical cancer." Journal of Clinical Oncology 41, no. 16_suppl (2023): e17521-e17521. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e17521.

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e17521 Background: Recurrent or progressive cervical cancer have limited second-line treatment options. Response rates are often poor to second-line therapy (average response rate of 15%). Identification of factors which predict response to immunotherapy and targets to enhance the immune response are critically needed in cervical cancer. Chronic inflammation can initiate an immune response in non-secondary lymphoid organs (SLO) and form a Tertiary Lymphoid Structure (TLS). TLS is composed of immune cells clustered and organized and responsible for immune cell chemotaxis, which impacts cancer t
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Sunyer, J. Oriol, Yasuhiro Shibasali, Fumio Takizawa, Ding Yang, Pierre Boudinot, and Aleksei Krasnov. "IDENTIFICATION OF PRIMORDIAL ORGANIZED LYMPHOID STRUCTURE IN THE SPLEEN OF TELEOST FISH." Journal of Immunology 204, no. 1_Supplement (2020): 92.40. http://dx.doi.org/10.4049/jimmunol.204.supp.92.40.

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Abstract Induction of adaptive immune responses in higher vertebrate species occur within organized lymphoid structures (e.g. lymph nodes, Peyer’s patches). It has been proposed that such structures emerged throughout evolutionary time with the goal to maximize encounters between antigens, antigens-presenting cells and B-T lymphocytes. Fish lack such structures and thus, it remains unknown how and where antigen-specific immunoglobulin responses are induced in these species. To understand how systemic immune responses are induced in teleost lymphoid organs, Rainbow Trout were immunized with sev
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Denton, Alice E., Silvia Innocentin, Edward J. Carr, et al. "Type I interferon induces CXCL13 to support ectopic germinal center formation." Journal of Experimental Medicine 216, no. 3 (2019): 621–37. http://dx.doi.org/10.1084/jem.20181216.

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Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context of infection, this response can be beneficial for the host: influenza A virus infection–induced pulmonary ectopic germinal centers give rise to more broadly cross-reactive antibody responses, thereby generating cross-strain protection. However, despite the ubiquity of ectopic lymphoid structures and their role in both health and disease, little is known about the mechanisms by which inflammation is able to convert a peripheral tissue into one that res
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van der Leun, Anne M. "Tertiary lymphoid structure formation: A matter of tumor-immune co-evolution." Molecular Immunology 175 (November 2024): 143–45. http://dx.doi.org/10.1016/j.molimm.2024.09.012.

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Tesis sobre el tema "Tertiary lymphoid structure"

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Devi, Priyanka. "Role and prognostic importance of regulatory T cells in lung cancer patients, according to the presence of tertiary lymphoid structures." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066345/document.

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Une tumeur est un environnement complexe comprenant à la fois des composants immunitaires et non immunitaires. Dans notre équipe, nous avons démontré précédemment le rôle des structures lymphoïdes tertiaires (TLS) dans les cancers du poumon, dans la génération de réponses anti-tumorales protectrices. Cependant, les tumeurs peuvent se développer en utilisant des mécanismes d’immunosuppression tels que l’infiltration des cellules T régulatrices (Tregs) dans le microenvironnement tumoral. Cette thèse a étudié le mécanisme présumé des Tregs dans la régulation des réponses immunitaires dans le canc
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Kaplon, Hélène. "Rôle des lymphocytes B associés aux structures lymphoïdes tertiaires dans la réponse clinique des patients atteints d’un cancer pulmonaire Cancer-Associated Tertiary Lymphoid Structures, from Basic Knowledge Toward Therapeutic Target in Clinic Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS565.

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Le microenvironnement tumoral est un acteur majeur du contrôle immunitaire du développement tumoral. Ce contrôle commence à distance des cellules tumorales, dans le stroma tumoral, au sein de structures appelées structures lymphoïdes tertiaires (TLS), composées d'une zone de lymphocytes B (LB) où se trouvent principalement des lymphocytes B (LB) adjacents à une zone T. Nos précédents résultats ont mis en évidence que la zone B des TLS peut être un site de différenciation des LB en LB mémoires et plasmocytes (PC), sécrétant principalement des IgA et IgG chez les patients atteints de cancer du p
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Houel, Ana. "Étude de l’induction de structures lymphoïdes tertiaires, par virothérapie oncolytique, pour stimuler l’immunité antitumorale endogène." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS232.

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Les structures lymphoïdes tertiaires (TLS) sont des agrégats organisés de cellules immunitaires qui se développent dans les tissus non-lymphoïdes à la suite d'une inflammation chronique. Les TLS matures, dont l'organisation est proche de celle d'un ganglion, sont associées à un bon pronostic dans les cancers à tumeurs solides et servent de prédicteur efficace de la réponse des patients traités par immunothérapie. Notre objectif a été d'étudier la virothérapie oncolytique comme stratégie pour induire des TLS dans le microenvironnement tumoral (TME) afin d'intensifier les réponses antitumorales.
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Le, Rochais Marion. "Cancer colorectal : apport pronostique de l’étude pathomique du microenvironnement tumoral. Focus sur les structures lymphoïdes tertiaires." Electronic Thesis or Diss., Brest, 2024. http://www.theses.fr/2024BRES0044.

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Le cancer colorectal est devenu un défi majeur pour les systèmes de santé en raison de sa prévalence croissante et de son impact sur la qualité de vie des patients. L'analyse anatomopathologique des prélèvements de cancer colorectal, désormais enrichie de données de pathologie moléculaire, est cruciale pour orienter le traitement des patients. Malgré les avancées dans les outils pronostiques et les traitements, les interactions entre les cellules tumorales et immunitaires du microenvironnement tumoral ne sont souvent pas évaluées de manière exhaustive en pratique diagnostique quotidienne. Cett
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Peyraud, Florent. "PRIORY : Caractérisation et rôle des cellules B et des structures lymphoïdes tertiaires chez les patients atteints de cancer et traités par immunothérapie." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0403.

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L'efficacité des inhibiteurs de point de contrôle immunitaire (ICI) dans le cancer du poumon non à petites cellules (CPNPC) a été associée à la présence de structures lymphoïdes tertiaires matures (mTLS) au sein du microenvironnement tumoral (MET). Cependant, seul un sous-groupe de patients atteints de CPNPC mTLS-positifs tire un bénéfice clinique, soulignant la nécessité de comprendre les déterminants de la réponse aux ICI. L'analyse complète de 509 patients atteints de CPNPC traités par ICI dans l'étude BIP (NCT02534649) a révélé que la présence de mTLS est corrélée à de meilleurs résultats
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Fouet, Morgane. "Modulation du microenvironnement tumoral et de la réponse immunitaire par des virus oncolytiques modifiés." Electronic Thesis or Diss., Nantes Université, 2024. http://www.theses.fr/2024NANU1008.

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Les virus présentant un tropisme pour les cellules tumorales et une capacité à induire leur lyse, sont appelé des virus oncolytiques. Ils sont utilisés dans le cadre de la virothérapie et permettent de stimuler la réponse immunitaire antitumorale par le recrutement et l’activation de cellules immunitaires innées et adaptatives. Les travaux issus de ma thèse ont permis d'approfondir la compréhension du rôle des lymphocytes Tϒ9δ2 dans le cadre des infections oncolytiques, en mettant notamment en lumière leur activation spécifique par la souche Schwarz du virus de la rougeole. J’ai ensuite dévelo
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Lucchesi, Davide. "Development and description of a novel inducible model of salivary gland inflammation in C57BL/6 mice characterised by tertiary lymphoid structures, autoimmunity and exocrine dysfunction." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8565.

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The accumulation of leukocytes in non-lymphoid tissues and their structural organization into tertiary lymphoid structures (TLS), a process known as ectopic lymphoid neogenesis (ELN), is observed in response to chronic inflammation and in the target organ of several autoimmune diseases. TLS strongly resemble secondary lymphoid organs with specialised high-endothelial venules (HEV), segregated B/T cell areas and presence of follicular dendritic cells (FDC) networks promoting in situ affinity maturation of the antibody response. TLS have been associated with a growing number of autoimmune condit
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Migliori, Edoardo. "The importance of CD4+ follicular helper T cells and tertiary lymphoid structures in the anti-tumor immune response to breast cancer." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/258252.

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Breast cancer (BC) is the most common cancer in women. It is a highly heterogeneous disease in terms of histology, therapeutic response and patient outcomes. Early and accurate detection of breast cancer is crucial as the patient prognosis varies greatly depending on the diagnosis of the disease. Patient outcomes have been linked to the presence of tumor infiltrating lymphocytes (TIL) in solid tumors. In human BC, higher TIL infiltration is associated with a better prognosis and also predicts relevant responses to pre-operative chemotherapy. TIL are primarily composed of T cells, albeit around
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Geyer, Elisabeth. "Akkumulation infiltrierender 6-sulfo LacNAc+ dendritischer Zellen im Kolonkarzinom." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226707.

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Das kolorektale Karzinom (KRK) zählt zu den immunogenen Tumoren und zeichnet sich durch eine ausgeprägte Infiltration von verschiedenen Immunzell-Populationen aus. Dabei scheinen insbesondere CD8+ T-Lymphozyten und CD4+ T-Helfer-Zellen Typ 1 das Tumorwachstum zu beeinflussen und spielen somit eine zunehmende Rolle als prognostische Marker. Dementsprechend ergaben sich mehrere Hinweise, dass eine hohe Frequenz dieser beiden T-Zell-Populationen in KRK-Geweben mit einer erhöhten Überlebensrate assoziiert ist. Diese neuen Erkenntnisse könnten zukünftig in die Klassifikation des KRKs einfließen und
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Giraldo-Castillo, Nicolas. "The Immune Microenvironment in Clear Cell Renal Cell Carcinoma : The heterogeneous immune contextures accompanying CD8+ T cell infiltration in clear cell Renal Cell Carcinoma." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066321/document.

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Dans cette étude, nous avons tenté de décrypter les mécanismes reliant l’augmentation de lymphocytes infiltrant les tumeurs (LIT) T CD8+ et un pronostic clinique défavorable dans le cancer du rein à cellules claires (ccRCC). Pour cela, nous avons déterminé 1) la relation entre le pronostic associé à l'expression d’immune checkpoints et l’infiltrat de cellules dendritiques (DC) et de LT CD8+ et 2) les caractéristiques phénotypiques des LIT T CD8+. L’expression des immune checkpoints a été déterminée par immunohistochimie dans une cohorte de 135 ccRCC. Nous avons constaté que les densités des ce
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Libros sobre el tema "Tertiary lymphoid structure"

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Dieu-Nosjean, Marie-Caroline, ed. Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2.

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Dieu-Nosjean, Marie-Caroline, ed. Tertiary Lymphoid Structures. Springer US, 2025. http://dx.doi.org/10.1007/978-1-0716-4184-2.

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Dieu-Nosjean, Marie-Caroline. Tertiary Lymphoid Structures: Methods and Protocols. Springer New York, 2018.

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Dieu-Nosjean, Marie-Caroline. Tertiary Lymphoid Structures: Methods and Protocols. Springer New York, 2019.

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Verma, Vivek, Catherine Sautes-Fridman, and Anna Dimberg, eds. Tertiary Lymphoid Structures: from Basic Biology to Translational Impact in Cancer. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-862-4.

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Capítulos de libros sobre el tema "Tertiary lymphoid structure"

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Louveau, Antoine. "Meningeal Immunity, Drainage, and Tertiary Lymphoid Structure Formation." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_3.

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Devi-Marulkar, Priyanka, Hélène Kaplon, Marie-Caroline Dieu-Nosjean, and Myriam Lawand. "Designed Methods for the Sorting of Tertiary Lymphoid Structure-Immune Cell Populations." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_11.

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Gu-Trantien, Chunyan, Soizic Garaud, Edoardo Migliori, Cinzia Solinas, Jean-Nicolas Lodewyckx, and Karen Willard-Gallo. "Quantifying Tertiary Lymphoid Structure-Associated Genes in Formalin-Fixed Paraffin-Embedded Breast Cancer Tissues." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_9.

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Couillault, Coline, Claire Germain, Bertrand Dubois, and Hélène Kaplon. "Identification of Tertiary Lymphoid Structure-Associated Follicular Helper T Cells in Human Tumors and Tissues." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_12.

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Gutierrez-Chavez, Claudia, Samantha Knockaert, Marie-Caroline Dieu-Nosjean, and Jérémy Goc. "Development of Methods for Selective Gene Expression Profiling in Tertiary Lymphoid Structure Using Laser Capture Microdissection." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_8.

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MacFawn, Ian P., and Tullia C. Bruno. "Tertiary Lymphoid Structure Formation and Function in the Tumor Microenvironment." In Handbook of Cancer and Immunology. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-030-80962-1_83-1.

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Silva-Sanchez, Aaron, Troy D. Randall, and Selene Meza-Perez. "Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_1.

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Corsiero, Elisa, Lucas Jagemann, Michele Bombardieri, and Costantino Pitzalis. "Generation of Recombinant Monoclonal Antibodies from Single B Cells Isolated from Synovial Tissue of Rheumatoid Arthritis Patients." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_10.

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Teillaud, Jean-Luc, Lucile Regard, Clémence Martin, Sophie Sibéril, and Pierre-Régis Burgel. "Exploring the Role of Tertiary Lymphoid Structures Using a Mouse Model of Bacteria-Infected Lungs." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_13.

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Rodriguez, Anthony B., J. David Peske, and Victor H. Engelhard. "Identification and Characterization of Tertiary Lymphoid Structures in Murine Melanoma." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_14.

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Actas de conferencias sobre el tema "Tertiary lymphoid structure"

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Li, Rong, Rui Chen, Jingwen Yue, Le Liu, and Zijian Jia. "Segmentation and Quantitative Evaluation of Tertiary Lymphoid Structures in Hepatocellular Carcinoma Based on Deep Learning." In 2024 2nd International Conference on Algorithm, Image Processing and Machine Vision (AIPMV). IEEE, 2024. http://dx.doi.org/10.1109/aipmv62663.2024.10692225.

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Yang, Yang, Mei Xie, Yimiao Feng, et al. "CellSeg2TLS: A Deep Learning Framework for Predicting the Maturation of Tertiary Lymphoid Structures in Pathology Images." In 2024 IEEE International Symposium on Biomedical Imaging (ISBI). IEEE, 2024. http://dx.doi.org/10.1109/isbi56570.2024.10635596.

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Karapetyan, Lilit, Xi Yang, Hong Wang, et al. "Abstract 2683: Serum multiplex analysis of tertiary lymphoid structure-associated chemokines/cytokines in melanoma patients." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2683.

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Liu, Dongyan, Xiang Li, Rajesh Acharya, et al. "Abstract PO-083: Utilizing spatial transcriptomics to elucidate tertiary lymphoid structure heterogeneity in human cancer." In Abstracts: AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact; September 17-18, 2020. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.tumhet2020-po-083.

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Koedijk, J. B., I. van der Werf, M. A. Vermeulen, et al. "Spatial analysis reveals distinct immune phenotypes and tertiary lymphoid structure-like aggregates in pediatric AML." In 34. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1768524.

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Wolfgang, Katelyn, Jessica A. Jana, Kristin Morder, Dipyaman Patra, Kelsey Ertwine, and Abigail E. Overacre-Delgoffe. "1264 Investigating the mechanisms ofHelicobacter hepaticusmediated lymphangiogenesis and tertiary lymphoid structure formation." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.1264.

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Arora, Charu, Renee R. Anderko, Noor Nader, Sheryl Kunning, Amer Zureikat, and Tullia C. Bruno. "1367 Autophagy inhibition in pancreatic ductal adenocarcinoma cancer patients modulates tertiary lymphoid structure activity and B cell function." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.1367.

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Wang, Xuefeng, Ranran Tao, Tingyi Li, et al. "137 Tertiary lymphoid structure signature in digital H&E slides as a prognostic biomarker in cutaneous melanoma." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.0137.

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Pimenta, Erica, Ryan Weiss, Dan Li, and Betsy Barnes. "Abstract 4141: Role of interferon regulatory factor 5 in anti-tumor immunity: Orchestration of a functional tertiary lymphoid structure." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4141.

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Ruiyi, Xu, and Wang Hui. "EP084/#264 The landscape of immune microenvironment and the poor prognostic value of tertiary lymphoid structure in gastric-type mucinous carcinoma." In IGCS 2023 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/ijgc-2023-igcs.188.

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Informes sobre el tema "Tertiary lymphoid structure"

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Lin, Liying, Min Li, Bo Fu, et al. Association between tertiary lymphoid structure and HNSCC: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.8.0031.

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