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Tesis sobre el tema "Tumourigenesis"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 6 de septiembre de 2023

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1

Maharjan, Rajani. "New Insights in Adrenal Tumourigenesis." Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-326149.

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Unilateral cortisol producing adenoma (CPA) is the most common cause of ACTH-independent Cushing’s syndrome and is surgically curable. On the other hand, adrenocortical carcinomas (ACCs) are rare and aggressive tumours. Although the overall survival of the patients with ACC is very poor, the outcome can be heterogeneous and vary significantly between the patients. This thesis comprises studies showing genetic and genomic events occurring in CPAs and ACCs, their functional impact and clinical correlations. The Wnt/β-catenin and cAMP/PKA signalling pathways are crucial in adrenal homeostasis and

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2

Oliver, Joseph James. "Characterizing ErbB2-induced mammary tumourigenesis." Thesis, Kingston, Ont. : [s.n.], 2007. http://hdl.handle.net/1974/687.

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3

Tam, Kevin J. "Semaphorin 3C in prostate cancer tumourigenesis." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61319.

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The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.<br>Medicine, Faculty of<br>Experimental Medicine, Division of<br>Medicine, Department of<br>Graduate

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4

Robinson, James Peter. "Tumourigenesis of Peutz-Jeghers Syndrome polyps." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522321.

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5

Aimls, Mark Anthony Slevin. "The role of gangliosides in tumourigenesis." Thesis, Manchester Metropolitan University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359140.

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6

Blyth, Karen. "A transgenic model to study the role of oncogenes and tumour suppression genes in T cell lymphoma." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321716.

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7

Johansson, Térèse A. "Pancreatic Endocrine Tumourigenesis : Genes of potential importance." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9294.

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<p>Understanding signalling pathways that control pancreatic endocrine tumour (PET) development and proliferation may reveal novel targets for therapeutic intervention. The pathogenesis for sporadic and hereditary PETs, apart from mutations of the <i>MEN1</i> and <i>VHL</i> tumour suppressor genes, is still elusive. The protein product of the <i>MEN1</i> gene, menin, regulates many genes. The aim of this thesis was to identify genes involved in pancreatic endocrine tumourigenesis, with special reference to Notch signalling.</p><p>Messenger RNA and protein expression of NOTCH1, HES1, HEY1, ASCL

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8

Small, Donna. "The role of cathepsin S in tumourigenesis." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580089.

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Recent studies have demonstrated that cysteine cathepsin S, predominantly from tumour- associated macrophages, promotes tumour development and progression. Conversely, previous work examining human colorectal and brain biopsies have shown that the tumour cells themselves are a major source of CatS. In order to clarify the contribution of stromal- derived versus tumour cell-derived CatS in colorectal tumourigenesis, investigations were carried out using the syngeneic MC38 coloadenocarcinoma cell line, which was found to expressed and produced CatS. Loss-of-function CatS experiments performed on

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9

Devlin, Andrea. "A study of CYP1B1 expression in tumourigenesis." Thesis, University of Ulster, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494336.

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10

Lynch, Catherine Anne. "Mechanisms of epigenetic gene silencing in tumourigenesis." Thesis, University of Ulster, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428611.

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11

Lewy, Gregory Douglas. "Novel pathways promoting thyroid tumourigenesis and growth." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3933/.

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Thyroid cancers are the most common endocrine malignancies and their incidence continues to rise. Over-expression of the human pituitary tumor transforming gene (hPTTG) in thyroid carcinomas is a prognostic indicator of tumour recurrence. hPTTG is multifunctional with roles in mitotic control, DNA repair, genetic instability, cell transformation and apoptosis. Importantly, hPTTG transactivates expression of growth factors implicated in proliferation and angiogenesis, and represses the sodium iodide symporter (NIS), which is essential to radioiodine treatments in thyroid cancer. hPTTG interacts

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12

Johansson, Térèse A. "Pancreatic Endocrine Tumourigenesis : Genes of potential importance /." Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9294.

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13

Ip, Julian Chung Yan. "Clinical and molecular aspects of adrenal tumourigenesis." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13738.

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The aims of this thesis were to examine the clinical and molecular aspects of benign and malignant adrenocortical tumours. Initial research focused on correlating KCNJ5 genotype-phenotype correlations in primary aldosteronism. It was noted that 41% patients were found to have somatic mutations in KCNJ5, G151R and L168R. Mutation carriers were predominately female and significantly younger at presentation and were more likely to be cured following surgery. Further work focussed on malignant adrenocortical carcinoma (ACC). Analysis in a cohort of patients showed that advanced age, advanced dise

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14

Sikkink, Stephen K. "Genetic pathology of non-small cell lung cancer." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250405.

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15

Su, Vi-Minh-Tri. "The role of Grb2 in HER2-mediates tumourigenesis." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110360.

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Grb2, an adaptor protein, is ubiquitously expressed and is involved in mediating a multitude of cellular processes in various body tissues such as development and tumourigenesis. Grb2 binds to proteins via its Src-homology domains and by doing so brings them in proximity of each other. In breast tissue, Grb2 can recruit SOS and Gab1 to the plasma membrane by binding to a specific phosphorylated tyrosine residue of HER2, a member of the epidermal growth factor receptor family. HER2 is overexpressed and activated in 20-30% of human breast cancers and correlates with poor patient prognosis. In tr

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16

Flaiz, Christine. "From merlin to tumourigenesis- the role of GTPases." Thesis, University of Exeter, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489979.

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Rac1, Cdc42 and RhoA are small RhoGTPases, molecular switches that regulate protrusion and adhesion to other cells and the extracellular matrix. The tumour suppressor merlin controls and is itself regulated by Rac1. Merlin-deficiency has been linked to many protrusive structures like lamellipodia and ruffles, defective intercellular adhesion leading to loss of contact inhibition of growth, and increased adhesion to the extracellular matrix.

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17

Basterfield, Laura. "Exercise and intestinal tumourigenesis in the Min mouse." Thesis, University of Newcastle Upon Tyne, 2006. http://hdl.handle.net/10443/753.

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Colon cancer is the third most frequently diagnosed cancer in the UK and is often associated with a "Westenf' style of eating, high in fat and low in vegetables and fruits. There is strong epidemiological evidence that more physical activity is associated with reduced risk of colon cancer, but the amount or type of activity necessary to invoke this protection is disputed, and the mechanism responsible has not been elucidated. In this project, Min mice were used in studies of the impact of physical activity on development of intestinal neoplasia. These mice have a mutation at codon 850 in the A

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18

McEvoy, Katherina Yasmin. "The role of desmosomal cadherins in colorectal tumourigenesis." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3466/.

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In cancer, loss of intercellular contact contributes to tumour progression and invasion. Desmosomal cadherins are essential constituents of desmosomes – intercellular junctions that confer significant adhesive strength to epithelial tissues and cardiac muscle. Although changes in desmosomal components have been noted in a variety of cancers previously, this investigation has shown for the first time altered desmocollin expression in colorectal cancer. Real-time PCR and western blotting were used to assess desmocollin expression in a series of colorectal cancer and matched normal tissue samples

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19

Sharma, Neil. "Novel binding partners of PBF in thyroid tumourigenesis." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4766/.

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Thyroid cancer is the most common endocrine cancer, with a rising incidence. The proto-oncogene PBF is over-expressed in thyroid tumours, and the degree of over-expression is directly linked to patient survival. PBF causes transformation in vitro and tumourigenesis in vivo, with PBF-transgenic mice developing large, macro-follicular goitres, effects partly mediated by the internalisation and repression of the membrane-bound transporters NIS and MCT8. NIS repression leads to a reduction in iodide uptake, which may negatively affect the efficacy of radioiodine treatment, and therefore prognosis.

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20

Cox, Adam. "Exploring mechanisms of prostate tumourigenesis in mouse models." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/70907/.

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Many cell signalling pathways contribute to prostate cancer (PCa) initiation and survival, but the interplay between them remains poorly understood. In this thesis, conditional transgenic models were employed to investigate the impact of mutating the proto-oncogenes β-catenin, and Kras, and the tumour suppressor gene PTEN, alone and in combination within the murine prostate. β-catenin and Pten single mutants display progression from PIN to invasive adenocarcinoma that appears similar to human Gleason pattern 3. Tumours demonstrate co-activation of the Wnt, PI3K/Akt/mTOR, and Ras/MAPK pathways.

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21

Tordella, Luca. "Investigation of the role of ASPP2 in tumourigenesis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:08fd41ee-14f4-4715-9629-b20955be4eb8.

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The skin is the site where two of the most common types of epithelial cancer, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), arise. In this work, we have investigated how ASPP2, a member of a family of proteins that interact with the p53 family, can affect skin tumourigenesis. ASPP2 is expressed in the squamous epithelia of various organs, localising exclusively in the upper and most differentiated layers. We show here that Balb/c ASPP2-null and heterozygous mice develop spontaneous SCCs. To investigate how the absence of ASPP2 from the epithelial compartment could lead to tumou

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22

Sharfeddin, Essam. "The role of gamma-synuclein in mammary gland tumourigenesis." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/44541/.

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Abstract y-synuclein is the third and last discovered member of the synuclein family, it is expressed mostly in the nervous system and its physiological function is still unknown. y-synuclein has been claimed to play a role in mammary gland tumourigenesis as its overexpression in cancer cells was shown to inhibit apoptosis and stimulate growth, proliferation, survival, motility and metastasis. However, the role of endogenous y-synuclein in mammary gland tumourigenesis has not been studied in an appropriate in vivo model. The results obtained in this study show that y-synuclein is not required

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23

Qin, Xiao. "The role of ASPP2 in intestinal homeostasis and tumourigenesis." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:a2d76d06-4361-4a39-8050-fd8a66a29218.

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The intestinal epithelium represents one of the most actively renewing tissues in the body, and is widely used as a model system to study epithelial cell biology. ASPP2, a member of the ASPP (apoptosis stimulating protein of p53) protein family, has been shown to act as a regulator of epithelial cell polarity and tumour suppressor. This study investigated whether the dual function of ASPP2 is involved in the regulation of intestinal homeostasis and tumourigenesis, with a particular interest in the distinction between epithelial cell autonomous and non-autonomous mechanisms. Germline and intest

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24

Perrett, Rebecca Mary. "The human germ cell lineage : pluripotency, tumourigenesis and proliferation." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/66010/.

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25

Silva, Lara Marques Loureiro. "ASPP2 regulating p63/p73 and Notch pathways in tumourigenesis." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10878.

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Mestrado em Biotecnologia Molecular<br>Na pele surgem dois dos tipos mais comuns de cancro epitelial, o carcinoma basocelular (BCC) e o carcinoma escamoso da pele (SCC). Neste trabalho, investigámos como ASPP2, membro da família de proteínas que interage com a família p53, pode afectar a tumurigénese da pele. Estudou-se a regulação por ASPP2 das vias de sinalização envolvidas na homeostasia normal do tecido epitelial, tais como as vias de p63 e Notch. A activação anormal de ΔNp63 no epitélio é uma causa conhecida para o surgimento do SCC e os nossos resultados indicam que a ASPP2 é importante

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26

Stefanatos, Rhoda Katerina Anne. "Modelling tumourigenesis and the stress response in Drosophila melanogaster." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4865/.

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27

Chung, Ho Ki Kathryn. "Investigating the role of iASPP in skin homeostasis and tumourigenesis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:60af22a6-c9d6-41a7-bd60-f6795e75d882.

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28

Heroux, Devon. "The role of an ErbB2 splice form in mammary tumourigenesis." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107895.

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Breast cancer is the second most common cancer in women, after skin cancer. Of particular severity in the disease is the ErbB2 subgroup, which represents 20-30% of all breast cancers, and has poor clinical prognosis. Various isoforms of ErbB2 exist, including an exon 16 removed form denoted ErbB2ΔEx16. This splice isoform has shown to play a role in drug resistance of the ErbB2 targeted therapeutic antibody Herceptin. Understanding the role this splice form has in resistance to other drugs is therefore essential for an effective regimen of therapeutics. Dasatinib, lapatinib and bosutinib are t

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29

Ranger, Jill. "Stat3 as a multifaceted regulator of mammary tumourigenesis and metastasis." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110488.

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Many forms of cancer express activated Stat3, a pleiotropic transcription factor that is implicated in pro-tumourigenic signaling in a variety of cancer cell lines, revealing that it may be important for tumour onset, progression, and malignancy. Yet, the role of Stat3 in the context of tumourigenesis in vivo is still unclear. Downstream of an activated form of ErbB2, we have demonstrated that Stat3 is dispensable for in vivo tumour initiation but is crucial for metastasis. Conversely, the loss of Stat3 in a novel inducible model of PyVMT-driven tumourigenesis revealed that Stat3 is necessa

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30

Lees, Nicholas Peter. "DNA alkylation damage and repair in human colorectal mucosal tumourigenesis." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393518.

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31

Daly, Carl S. "The roles of the Apc proteins in homeostasis and tumourigenesis." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/51008/.

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The adenomatous polyposis coli (APC) gene encodes a multifunctional tumour suppressor protein that is essential for normal development. The most characterised role of APC is its ability to mediate the Wnt signaling pathway, a pathway disrupted in the majority of human cancers. The identification of a second adenomatous polyposis coli gene (APC2) which possesses many shared structural characteristics with APC and potentially comparable functions raises the possibility that APC2 also functions both in development and in tumour suppression, and that some redundancy may exist between the two prote

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32

Stratford, Anna. "Molecular mechanisms of the PTTG Binding Factor (PBF) in tumourigenesis." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433637.

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33

Pollock, Claire B. "The role of oncogenic K-Ras signalling in colorectal tumourigenesis." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398766.

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34

Cooke, James C. "Molecular investigations of phaeochromocytoma tumourigenesis in von Hippel-Lindau disease." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417558.

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35

Pantazi, Eleni. "The role of GLI2 in human basal cell carcinoma tumourigenesis." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/508.

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Abnormal Sonic Hedgehog (SHH) signalling leads to increased transcriptional activation of its downstream effector, GLI2, which is implicated in the pathogenesis of a variety of human tumours, including human basal cell carcinoma (BCC). However, little is known about the molecular mechanisms underlying the tumourigenic role of GLI2 in human skin keratinocytes. This study examines the effects of inducible and stable expression of constitutively active GLI2 (GLI2:N) oncogenic transcription factor, on immortalised human epidermal keratinocytes. It is shown here that GLI2:N overexpressing N/TERT ke

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36

Niederreiter, Lukas. "Endoplasmic reticulum (ER) stress transcription factor Xbp1 in intestinal tumourigenesis." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708846.

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37

Benedykcinska, A. M. "Multiple roles of β-catenin in brain development and tumourigenesis". Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1436079/.

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β-catenin is a multifunctional protein with roles in Wnt pathway signal transduction and in cell adhesion. While the normal function of β-catenin is important for CNS development, Wnt pathways have also been intrinsically linked to cancer. Here, the multiple roles of β-catenin in CNS development and in brain tumour pathogenesis were investigated. All experiments used a mouse model where a dominant active form of β-catenin can be induced by Cre mediated recombination of the exon 3 of the CATNNB gene. Three models were established to analyse the effects of dominant active β-catenin: (i) during d

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38

Grant, Nicola Joan. "Reassessing the role of Cyclin-dependent kinase 5 in tumourigenesis." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/e642934d-14f9-4f12-b476-a22629d4b89e.

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The discovery of Cyclin-dependent 5 (Cdk5) added a new member to the mammalian Cdks, appearing uncharacteristic of its family members despite strong sequence homology. In contrast to the mitotic Cdks, Cdk5 exerts no apparent role in cell cycle regulation therefore its potential role in cancer is subject to much controversy. Cdk5 is heavily depicted as a neuronal-specific kinase, due to its association with neuronal activators, and dysregulation of Cdk5 activity is thought to contribute to the pathogenesis of several neurodegenerative diseases, including Alzheimer’s disease. Nonetheless, the ph

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39

Ma, Jingyi. "Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:5a3100e0-7875-4c05-9a63-494932d44335.

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The tumour microenvironment (TME) is frequently hypoxic and inflammatory, leading to the activation of the Hypoxia-Inducible Factor (HIF) family of transcription factors. HIF has been shown to exert broad, and sometimes controversial, effects on tumour progression through the induction of over 70 effector genes. Factor Inhibiting HIF (FIH), an oxygen-dependent hydroxylase of HIF, inhibits the transcription of selective HIF target genes, and is hence a potential therapeutic target to fine-tune HIF activity. However, how FIH may affect tumourigenesis has not been comprehensively investigated. By

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40

Gan, Pei Pei Children's Cancer Institute Australia for Medical Research Faculty of Medicine UNSW. "Determining the role of β-tubulin isotypes in drug resistance and tumourigenesis in lung cancer cells". Publisher:University of New South Wales. Children's Cancer Institute Australia for Medical Research, 2009. http://handle.unsw.edu.au/1959.4/43357.

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Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide and in its advanced stage, has a poor clinical outcome. Resistance to chemotherapeutic agents, either intrinsic or acquired, is the primary cause of treatment failure in NSCLC. Tubulin binding agents (TBAs), such as paclitaxel and vinorelbine are important components in the treatment of NSCLC. Upregulation of the neuronal specific class III β-tubulin (β-III-tubulin) is frequently found in drug resistant cancer cell lines and human tumours, lending support that βIII-tubulin might play a role in the develop

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41

Park, Hyun-Sook. "Crypt fission in the spread of muted clones in the intestinal epithelium." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266423.

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42

Coy, Joanna Lucy. "Epstein Barr nuclear antigen 1 induced lymphoma in transgenic mice." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241746.

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43

Miao, Yu Rebecca. "The role of c-Myb in mammary gland development and tumourigenesis." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/7069.

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c-Myb/MYB is an established and key player in hematopoietic malignancies but more recently a strong case for c-Myb as an oncogene in breast cancer has emerged. c-Myb and its transcriptional target genes have direct bearing on tumour initiation and progression and thus this has opened new opportunities to the development of therapeutic approaches in a range of cancer types with the aim of treating cancer at its various stages. In this study, the requirement of c-Myb during mammary gland tumourigenesis is being examined. In addition a direct therapeutic approach to targeting c-Myb-driven gene gr

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44

Tho, Lye Mun. "Investigating the role of Chk1 in mouse skin homeostasis and tumourigenesis." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2504/.

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Chk1 is a key regulator of DNA damage response and genome stability in eukaryotes. To better understand how checkpoint proficiency affects cancer development particularly tumours induced by chemical carcinogens in murine skin, I investigated the effect of conditional genetic ablation of chk1. I found that complete deletion of chk1 immediately prior to carcinogen exposure strongly suppressed papilloma formation, and the few, small lesions that did form always retained Chk1 expression. Remarkably, chk1 deletion was accompanied by spontaneous cell proliferation followed by DNA damage and cell dea

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45

Mohamed, Noha-Ehssan. "Characterizing the roles of APC2 protein in ovarian homeostasis and tumourigenesis." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/105634/.

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Canonical WNT signalling plays a critical role in the regulation of ovarian development during embryogenesis; dysregulation of this pathway in adult ovary is associated with subfertility and tumourigenesis. The aim of the current study was to elucidate the previously unexplored roles of Adenomatous polyposis coli 2 (APC2), a WNT signalling pathway regulator, in the ovary using an Apc2 constitutive knockout mouse. For the first time, the current work demonstrated essential roles of APC2 in regulating ovarian WNT signalling and ovarian homeostasis. In early adulthood, APC2-deficiency resulted in

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46

Veerakumarasivam, Abhimanyu. "Integromic analysis of urothelial cell carcinoma identifies key targets in tumourigenesis." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611565.

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47

Podmore, Lauren. "The role of the p66-Shc adapter protein in mammary tumourigenesis." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119690.

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The ShcA adaptor protein is a key signaling molecule in the regulation of survival, angiogenesis, immune suppression and metastasis in breast cancer cells. The mammalian ShcA gene encodes three isoforms which are produced through alternative translation initiation (p46Shc, p52Shc) or different promoter usage (p66Shc). Although p46Shc and p52Shc are constitutively expressed and confer pro-tumorigenic signals, p66Shc levels vary in cancer cell lines. While activation of p66Shc through phosphorylation of its serine-36 (S36) is known to induce reactive oxygen species (ROS) formation, the role it p

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48

Wu, Xuemei. "Genetic control of tumour susceptibility in mouse skin carcinogenesis." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312688.

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49

Davoodi-Semiromi, Abdoreza. "Molecular pathology of the hMSH2 mutator gene and its transcripts in patients with colorectal cancer in the west of Scotland." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241714.

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50

Suaeyun, Ratchada. "The cellular roles of MDM2 and its alternatively spliced variants." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340667.

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