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Thèses sur le sujet « Associated protein 1 (BAP) »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Aveic, Sanja. "Role of BCL-2 associated athanogene - 1 (BAG-1) in Acute Myeloid Leukemia (AML): protein with hundred faces." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427500.

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Bcl-2 associated AthanoGene-1 (BAG-1) is a multifunctional protein competent to delay cell death by a synergistic action with Bcl-2. BAG-1, as well as Bcl-2, has been reported as deregulated in diverse cancer types. During PhD study, we confirmed BAG-1 protein as over-expressed in a cohort of leukemic cell lines and heterogeneously expressed in patients affected by de novo acute myeloid or lymphoid leukemia. Silencing approach, used for a determination of BAG-1’s role in AML, suggested a correlation between BAG-1 down-regulation and decreased expression of certain proteins, which contribution

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2

Brunn, Jonathan. "Investigation of Possible Novel Peptide Inhibitors to BAG-1 Based On Peptidyl-Biomimetics." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2942.

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In this Master’s Thesis Research the results can be summarized from two major tasks: (1) In our first task, we utilized our two protein system (BAG-1 and HSP 70) as part of beta testing of a computational software 1 that can take three dimensional x-ray crystallography information about protein complexes and predict the strength of atom –atom interactions between amino-acid residues Open Contact predicts binding hotspots that can be used to identify short amino acid chains or peptides that mimic that particular binding segment of the larger protein. These peptides are called pepidyl-biom

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3

Shurte, Leah A. "Determining Protein-Protein Interactions of ALS-Associated SOD1." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1464283630.

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4

Aviat, Florence. "Étude d'une protéine de leptospires : Hemolysis Associated Protein 1 : Hap 1." Nantes, 2006. http://www.theses.fr/2006NANT2012.

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La leptospirose est une zoonose de représentation mondiale concernant la plupart des Mammifères dont l'homme. Hap1 a été purifiée dans une fraction protéique de 32 kDa extraite de leptospires, bactéries responsables de la leptospirose. La protéine Hap1 s'est révélée être associée à une protection hétérologue contre la leptospirose chez des gerbilles. Le gène hap1 a été exprimé par E. Coli afin de produire la protéine recombinante rHap1. Ce travail confirme et prolonge les travaux antérieurs : Hap1 est secrétée par les seuls leptospires pathogènes lors de leur multiplication. Très immunogène et

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5

Stefani, Flavia. "Characterising the function of ubiquitin associated protein 1 (UBAP1)." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/characterising-the-function-of-ubiquitin-associated-protein-1-ubap1(cb81f935-7b1a-4b84-b806-fcd212fc1b84).html.

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Inactivating EGF signalling is key to modulating cell growth and avoiding cancer. To do this, the EGF receptor is ubiquitinated, internalized and sorted to lysosome for degradation. This latter process is coordinated by the endosomal sorting complex required for transport (ESCRT) machinery, a multi-complex protein machinery divided into four groups: ESCRT-0, I, II, III. ESCRTs recognise ubiquitinated cargoes and sort them from the limiting membrane of intermediate vesicles of maturing endosomes. In mammalian cells, the ESCRT machinery is also involved in other membrane related events, such as

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6

Hassanjani, Mahdieh. "Molecular characterization of the Parkinson's associated protein DJ-1." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/39640.

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Mutations in DJ-1 (PARK7), a conserved protein of 189 amino acids, cause autosomal recessive cases of Parkinson’s disease (PD). DJ-1 appears to play a central role in protecting cells from oxidative stress, which likely has relevance for its role in PD pathogenesis. Biochemical and crystallographic approaches indicate that DJ-1 dimerizes, which is likely fundamental for its stability and normal function. A main focus of this thesis was identifying and characterizing DJ-1 dimerization modifiers through an unbiased screen of a kinase and phosphatase inhibitor library, taking advantage of bimolec

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7

Curtis, Rory Alec John. "Growth-associated protein-43 in the rat nervous system." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46734.

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8

Laudon, Hanna. "Functional domains in the Alzheimer's disease-associated presenilin 1 protein /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-085-0/.

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9

Hsin, Yu Chang. "A molecular analysis of the microtubule associated protein MAP65-1." Thesis, Durham University, 2006. http://etheses.dur.ac.uk/2658/.

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Microtubules (MTs) play important roles in various cellular processes including cell division, organelle movement and the determination of cellular morphology. The dynamics and organization of microtubules are regulated by microtubule associated proteins (MAPs).MAP65 bundles microtubules and forms crossbridges between microtubules in vitro. MAP65 belongs to a group of phylogenetically divergent proteins which includes yeast (s. cerevisiae) Asel, insect (D. melanogaster) FEO, mammalian {H. sapiens) PRC1, and worm (C. elegans) SPD-1. All members of this group concentrate in the spindle midzone d

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10

Howard, Alexander E. "Characterization of DNA Methyltransferase 1-Associated Protein from Phytophthora sojae." Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1498172183304139.

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11

Farah, Sahar. "Identification of Rho-associated protein kinaseÃ as an insulin receptor substrate-1 binding protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ28422.pdf.

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12

Farah, Sahar. "Identification of Rho-associated protein kinase-alpha as an insulin receptor substrate-1 binding protein." Thesis, University of Ottawa (Canada), 1998. http://hdl.handle.net/10393/4152.

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Insulin receptor substrate-1 (IRS-1) is phosphorylated on multiple tyrosine residues by ligand-activated insulin receptor. These tyrosine phosphorylation sites serve to dock several SH2-containing signaling proteins. In addition, IRS-1 also contains several protein modules that have been implicated in protein-protein or protein-lipid interactions. In an attempt to identify novel proteins that may interact with these IRS-1 protein modules, yeast two-hybrid screening was employed. The bait, corresponding to the N-terminal 500 amino acids of the Xenopus IRS-1 (XIRS-1), was comprised of a pleckstr

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13

Choy, Catherine Theresa. "Kallmann syndrome-associated protein anosmin-1 contributes to brain tumour malignancy." Thesis, St George's, University of London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.656859.

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Anosmin-l, encoded by KALl gene, is an extracellular matrix (ECM)-associated protein, which plays essential roles in the migration of olfactory and gonadotropinreleasing hormone (GnRH) neurons during early brain development. Loss-of-function mutations in KALl result in Kallmann syndrome, a developmental genetic disorder with delayed puberty and anosmia. However, there is little comprehension of its role in the developed brain. Since reactivation of developmental signal pathways often contributes to tumourigenesis, I investigate if anosmin-l-mediated cellular mechanisms are involved in brain tu

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14

Valdez, Yanet. "The role of natural resistance-associated macrophage protein 1 (Nramp1) in salmonellosis." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/6845.

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Salmonellosis poses a global threat to human health. Host resistance against Salmonella enterica serovar Typhimurium (S. Typhimurium) in the murine model is mediated by Natural resistance-associated macrophage protein 1 (Nramp1/Slc11a1). Nramp1 is critical for host defense, as mice lacking Nramp1 fail to control bacterial replication and succumb to low doses of S. Typhimurium. Despite this critical role, the mechanisms underlying Nramp1’s protective effects are unclear. This thesis presents a detailed analysis of Nramp1 expression in the murine gastrointestinal tract and its impact on S. Ty

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15

Tan, Yan Ling Shireen. "Downregulation of multidrug resistance-associated protein 1 by UL138 of human cytomegalovirus." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708424.

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16

Fonjungo, Peter Nkong. "Human antibody responses to Plasmodium falciparum merozoite rhoptry associated protein 1 (RAP1)." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/12022.

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My main aim was to investigate human Ab responses to RAP1. For this study, I have developed nine recombinant RAP1 proteins (rRAP1) representing almost the entire sequence of mature RAP1 that have been expressed in <I>Escherichia coli</I> as soluble hexa-histidine or GST fusions. The antigenicity of the rRAP1 proteins was assessed by immunogenicity tests in mice and rabbits, and by <I>P. falciparum </I>RAP1-specific mAbs recognising a defined linear epitope. Antisera to seven of the rRAP1 proteins specifically reacted with parasites in immunofluorescence as well as parasite-derived RAP1 protein

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17

Forbes, Jonathan. "BIOCHEMICAL CHARACTERIZATION OF SUPPRESSOR OF IKK-ε AND NAK-ASSOCIATED PROTEIN 1". VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/86.

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Innate immunity provides the first line of defense against invading pathogen by recognizing and mounting a response to the pathogenic challenge. Among the cellular mechanisms of the innate immune response, Toll-like receptor 3 (TLR3) recognizes viral dsRNA and signals subsequent production of type-I interferon. The TLR3:interferon signaling cascades contains a kinase complex composed of two kinases and a scaffold protein, NAK-associated protein 1 (NAP1). The role of NAP1 in modulating kinase activation or regulation is unknown. A key inhibitory protein identified in the TLR3:interferon pathway

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18

Tian, Wang, la Vega Montserrat Rojo de, Cody J. Schmidlin, Aikseng Ooi, and Donna D. Zhang. "Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)." AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2018. http://hdl.handle.net/10150/627124.

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Nuclear factor erythroid-2-related factor 1 (NRF1) and NRF2 are essential for maintaining redox homeostasis and coordinating cellular stress responses. They are highly homologous transcription factors that regulate the expression of genes bearing antioxidant-response elements (AREs). Genetic ablation of NRF1 or NRF2 results in vastly different phenotypic outcomes, implying that they play different roles and may be differentially regulated. Kelch-like ECH-associated protein 1 (KEAP1) is the main negative regulator of NRF2 and mediates ubiquitylation and degradation of NRF2 through its NRF2-ECH

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19

Lavigueur, Olivier. "Identification of newly synthesized HIV-1 pr55gag on Lysosmal-associated membrane protein-1 late endosomal vesicles." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86856.

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Recent work published from our lab showed that modulation of the dynein motor complex affected HIV-1 viral production but not viral infectivity and that trafficking of viral components played an important role in assembly. It was further demonstrated that viral genomic RNA and the HIV-1 structural protein pr55Gag co-localized on LAMP-1 - a transmembrane glycoprotein found on endosomal and lysosomal membranes - late endosomal vesicles. Using the Lumio dyes fluorescein arsenical helix binder (FlAsH) and resorufin arsenical helix binder (ReAsH) and TC-tagged Gag-TC and pNL4-3TC constructs, we sh

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20

Hofer, Matthias Dominikus. "Funktionelle Charakterisierung des metastasis associated protein 1 (MTA1) durch Überexpression in der humanen Pankreaskarzinomzelllinie PANC-1." Ulm : Universität Ulm, Medizinische Fakultät, 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10070628.

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21

Gan, Lu. "The Involvement of Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) as a Critical Modulator of Macrophage Migration." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77071.

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Macrophage migration, an essential component of many biological processes and pathologic conditions, is mediated by integrated cellular signaling processes and cytoskeleton rearrangement. Recent advances indicate that the innate immunity signaling process plays a key role in the regulation of macrophage migration. Furthermore, our lab has provided evidence demonstrating the involvement of a key innate immunity signaling kinase, IRAK-1, as a critical modulator of murine macrophage migration. Macrophage migration induced by a potent PKC activator, phorbol 12-myristate 13-acetate (PMA), or lipopo

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22

Shiban, Ehab [Verfasser]. "Characterization of the Proline-rich Synapse-associated Protein 1 Knockout Mouse / Ehab Shiban." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1035802562/34.

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23

Mazzarol, Flavia. "The Parkinson's disease associated DJ-1 protein is modified by SUMO-2/3." Doctoral thesis, SISSA, 2007. http://hdl.handle.net/20.500.11767/4783.

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24

Hankey, William C. IV. "Chromatin-associated functions of the APC tumor suppressor protein." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480198247672881.

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25

Schulze, Andrea. "A role for the ubiquitin domain protein HERP in ER-associated protein degradation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15575.

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Die ER-assoziierte Proteindegradation (ERAD) ist Teil des Qualitätskontrollsystems am ER, um der Akkumulation von fehlgefalteten Proteinen im ER entgegenzuwirken. Hierbei werden ERAD-Substrate mit Hilfe von E3-Ligasen wie z.B. HRD1 ubiquityliert und anschließend durch den p97-Ufd1-Npl4 Komplex aus der ER-Membran extrahiert. Im Zytosol werden diese extrahierten Proteine vom 26S Proteasom abgebaut. Für die Retrotranslokation von ERAD- Substraten werden zudem die Membranproteine Derlin-1 und VIMP benötigt, welche mit p97 assoziieren und einen Proteinkomplex bilden. HERP ist ein ER-lo

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26

Lam, Chi Keung. "The Novel Role of Hematopoietic Lyn Substrate-1 Associated Protein X-1 in Cardiac Contractility and Cardioprotection." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353098605.

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Hanssen-Bauer, Audun. "X-ray repair cross-complementing protein 1 associated multiprotein complexes in base excision repair." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kreftforskning og molekylær medisin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-16986.

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XRCC1 assoierte multiproteinkomplekser i base eksisjonsreparasjon Arvestoffet (DNA) degraderes konstant av ytre faktorer, som stråling og kjemikalier, og indre faktorer, som produkter av metabolismen. Slik degradering ødelegger informasjonen som ligger i DNA, og kan derfor være toksisk for cellene og mutagent under replikasjon. Sannsynligheten for mutasjon er likevel ekstremt lav fordi DNAets integritet opprettholdes ved en lang rekke reparasjonsmekanismer. Disse involverer mange enzymer, struktur- og regulatoriske proteiner, med overlappende roller. Feil eller mangelfull reparasjon er drivkr

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28

Sever, Richard. "Roles of protein kinases in the regulation of AP-1 and associated transcription factors." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245165.

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29

Joshi, Pooja Laxmikant. "Effects of resistin on platelet function and its receptor, adenylyl cyclase associated protein 1." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/18450/.

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Resistin is an adipokine which is found elevated in patients suffering from metabolic syndrome, affecting a large proportion of the population. It is characterised by obesity, insulin resistance (IR), type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), which are the biggest contributors to morbidity and mortality in the modern world. Platelets play a major role in CVD, where their activation leads to formation of thrombi, which when uncontrolled, leads to the pathophysiological effects of CVD. The role of resistin in CVD progression and its mechanism of action on its target cells

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30

Richter, Judith [Verfasser]. "Funktionelle Analyse einer neuartigen Proteininteraktion des TNF-receptor associated protein 1 (TRAP1) / Judith Richter." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/1045276375/34.

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31

Hofer, Matthias Dominikus [Verfasser]. "Funktionelle Charakterisierung des metastasis associated protein 1 durch Überexpression in der humanen Pankreaskarzinomzelllinie PANC-1 / Matthias Dominikus Hofer." Ulm : Universität Ulm. Medizinische Fakultät, 2002. http://d-nb.info/1015324541/34.

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32

Graf, Justin T. "Membrane associated transporter protein gene (SLC45A2) and the genetic basis of normal human pigmentation variation." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/25913/1/Justin_Graf_Thesis.pdf.

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This work is concerned with the genetic basis of normal human pigmentation variation. Specifically, the role of polymorphisms within the solute carrier family 45 member 2 (SLC45A2 or membrane associated transporter protein; MATP) gene were investigated with respect to variation in hair, skin and eye colour ― both between and within populations. SLC45A2 is an important regulator of melanin production and mutations in the gene underly the most recently identified form of oculocutaneous albinism. There is evidence to suggest that non-synonymous polymorphisms in SLC45A2 are associated with normal

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33

Lau, Timothy. "A protein tyrosine kinase associated with the ATP-dependent inactivation of adipose diacylglycerol acyltransferase-1." Thesis, University of Ottawa (Canada), 1995. http://hdl.handle.net/10393/9841.

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An enzyme activity that reversibly inactivates adipose glycerolphosphate acyltransferase (GPAT) and diacylglycerol acyltransferase (DGAT), in vitro, in the presence of ATP, has been partially purified from adipose tissue with an apparent molecular weight of 68 kDa. The activity responsible for inactivation DGAT is associated with a kinase activity as determined by phosphate incorporation into microsomes and a tyrosine containing peptide. Major substrates of this kinase are two microsomal polypeptides of 53 and 69 kDa. Both DGAT inactivation and kinase activities assayed from the purified sampl

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34

Zhang, Wei. "LOSS OF MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (MRP1/ABCC1) POTENTIATES DOXORUBICIN-INDUCED CARDIOTOXICITY IN MICE." UKnowledge, 2015. http://uknowledge.uky.edu/toxicology_etds/12.

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Doxorubicin (DOX) is a broad-spectrum and effective chemotherapeutic agent, but its use in oncologic practice is limited by dose-dependent cumulative cardiotoxicity. DOX-induced cardiotoxicity is in large part due to its ability to cause oxidative stress. Multidrug resistance associated protein 1 (MRP1/ABCC1) is a member of the ATP-binding cassette (ABC) transporter superfamily. By effluxing a wide variety of endogenous and exogenous substrates, Mrp1 plays important physiological roles in multiple tissues and also protects normal tissues against toxicants. However, the role of MRP1 in heart is

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35

Call, Richard. "EXAMINATION OF NAK-ASSOCIATED PROTEIN-1 (NAP1) HOMO AND HETERO-INTERACTIONS IN THE INTERFERON PATHWAY”." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2502.

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Double stranded RNA (dsRNA), the genomic material of some viruses and a replication intermediate in others, is recognized by multiple signaling receptors that initiate the anti-viral response1. Viruses have developed mechanisms to circumvent the anti-viral response by targeting components of the signaling pathway. An example of one such pathway is the TLR3 signaling pathway, which contains a kinase complex that activates interferon regulatory factor 3 (IRF3), leading to production of type I interferons. The kinase complex consists of a scaffold protein, NAK-associated protein 1 (NAP1), a

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Goswami, T. "A study of the murine and human homologues of the natural resistance associated macrophage protein 1." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599542.

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To investigate the possibility that apoptotic cell death is a mechanism by which Nramp1 mediates resistance to macrophage infection, the influence of Nramp1 on cellular apoptosis was studied by DNA fragmentation analyses using the Nramp1<SUP>WT</SUP> and Nramp1<SUP>M</SUP> macrophage cell lines. It was observed that basal levels of apoptosis were higher in Nramp1<SUP>WT</SUP> cells than Nramp1<SUP>M</SUP> macrophages. The effect of activation with LPS and/or IFNγ on apoptosis appeared to be Nramp1-independent. Experiments with the iNOS specific inhibitor, SMT, and the NO donor, sodium nitropru

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Leonard, April. "A genetic approach towards identifying genes involved in the targeting of plasmodesmal-associated protein kinase 1." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 155 p, 2008. http://proquest.umi.com/pqdweb?did=1601234911&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Kiso, Honoka. "Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations." Kyoto University, 2014. http://hdl.handle.net/2433/192145.

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Kiso H, Takahashi K, Saito K, Togo Y, Tsukamoto H, et al. (2014) Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations. PLoS ONE 9(5): e96938.<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第18545号<br>医博第3938号<br>新制||医||1006(附属図書館)<br>31445<br>京都大学大学院医学研究科医学専攻<br>(主査)教授斎藤通紀, 教授戸口田淳也, 教授妻木範行<br>学位規則第4条第1項該当

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Zhang, Wendy W. "The Role of ALS8-linked VAMP-associated Protein B (VAPB) in Caenorhabditis elegans Motor Neurons." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32242.

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Amyotrophic Lateral Sclerosis (ALS) is a fatal, late-onset, progressive neurodegenerative disease. A familial form of ALS, autosomal dominant ALS8, is characterized by a mutation in an ER membrane protein, VAPB. To characterize the role of VAPB in motor neurons, two C. elegans models were generated: one expressing human VAPB-P56S and another with the knockdown of C. elegans VAPB ortholog, VPR-1. Overexpression of human VAPB in DA neurons caused backward locomotion defects, enhanced vulnerability to oxidative stress and premature neuronal death. Knockdown of vpr-1 in C. elegans recapitulated th

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Nanayakkara, Sachith N. "The role of IGF-1 and hormone binding proteins in understanding insulin-associated equine laminitis." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/118300/1/Sachith_Nanayakkara_Thesis.pdf.

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Laminitis is a common and extremely painful hoof disease in horses. We know that it is caused by abnormally high levels of insulin, but the mechanism of insulin action is not known. One theory is that insulin over-stimulates the receptors for a related hormone, insulin-like growth factor-1, and that this leads to uncontrolled cell proliferation in the hoof, which ultimately causes the disease. The first part of the thesis examines this theory, by determining if insulin can activate IGF-1 receptors directly, or displace IGF-1 from its binding proteins in blood, thereby increasing the activity o

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Sarkar, Mohosin M. "Engineering Proteins with GFP: Study of Protein-Protein Interactions In vivo, Protein Expression and Solubility." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1261418776.

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42

Kajita, Yoichiro. "The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1(AFAP1L1)." Kyoto University, 2013. http://hdl.handle.net/2433/179345.

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Nord, Dianna M. "Knockdown of the Yes-associated Protein 1 pathway provides a basis for targeted therapy to treat infantile hemangioma." Thesis, Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53736.

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Hemangioma is a type of tumor commonly found in infants that is characterized by heavy vascularization and a disfiguring appearance. Hemangioma, though benign, can sometimes proliferate and be threatening to infants. Current treatments for infantile hemangioma include surgical removal as well as the use of topical and oral medication. However, current therapies are often ineffective at treating lesions and are commonly accompanied by dangerous side effects, creating the need for a new, safer treatment. This study targets the Yes-Associated Protein-1 (YAP-1), which has been described as an onco

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Baker, Anne-Marie. "Natural resistance-associated macrophage protein (Nramp) : genetic mapping around the locus on chromosome 1 and comparative sequence analysis." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388368.

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Bryan, Nicole B. "Subcellular distribution of apoptosis associated speck-like protein mediates inflammasome assembly a novel mechanism in the regulation of interleukin-1beta release /." Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/11239.

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Thesis (Ph. D.)--West Virginia University, 2010.<br>Title from document title page. Document formatted into pages; contains x, 182 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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Zhang, Shuting. "The effect of FAD-associated mutations in amyloid-beta precursor protein and presenilin-1 genes on Alzheimer’s disease pathogenesis." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44983.

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Pathogenic mutations in amyloid-β precursor protein (APP) and presenilins (PS) genes cause familial Alzheimer’s disease (FAD). FAD is an uncommon form of Alzheimer’s disease (AD) with early onset (before age 65) and a rapid progression but its neuropathology is indistinguishable from the sporadic AD. Amyloid plaque is the unique hallmark of AD, which consists primarily of 40- and 42-residue amyloid β protein (Aβ40 and Aβ42) with the more hydrophobic Aβ42 as its major component. Aβ is derived from APP through sequential cleavages by β-secretase and γ-secretase. According to the “Amyloid

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Schmitt, Sven Marcel [Verfasser]. "Purines and 9-deazapurines as Modulators of Multidrug Resistance-associated Protein 1 (MRP1/ABCC1)-mediated Transport / Sven Marcel Schmitt." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1149154101/34.

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COSTANTINI, Cristiana. "PROGETTAZIONE E SINTESI DI POTENZIALI AGENTI ANTITUMORALI INIBITORI DEL CHAPERONE MITOCONDRIALE "TUMOR NECROSIS FACTOR-RECEPTOR ASSOCIATED PROTEIN 1" (TRAP1)." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2389064.

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It is well known that Hsp90 chaperone protein contributes in stabilizing oncoproteins over-expressed in malignant cell lines, playing a key role in survival, proliferation, invasion, metastasis and angiogenesis, which represent the hallmark traits of the cancer.1 In the last decade Hsp90 has emerged as a possible therapeutic target and many efforts have been dedicated to the discovery of Hsp90 inhibitors as new potent anticancer agents. TRAP 1 (Tumor Necrosis Factor-Associated Protein ), the mitochondrial isoform of Hsp90, is a component of a mitochondrial pathway selectively up-regulated in t

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Srinivasan, Srilakshmi. "Functional analysis of prostate cancer-associated germline variants in the kallikrein-3 gene." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/108027/1/Srilakshmi_Srinivasan_Thesis.pdf.

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This thesis is a comprehensive analysis of two functional germline variants of prostate specific antigen (PSA), the current widely used biomarker for prostate cancer diagnosis. It examines the mechanisms through which the two germline variants play a role in prostate cancer pathogenesis. Additionally, the clinical impact of these two variants in mediating the detection of the PSA protein in serum of men was analysed. This project is a step forward in utilising these germline variants, that lead to changes to the PSA protein, to personalise the current approach for prostate cancer diagnostics.

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Sahin, Katherine B. "Evaluation of cell division cycle associated protein 3 (CDCA3) as a novel prognostic/therapeutic target for EGFR-mutant non-small cell lung cancer." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/231468/1/Katherine_Sahin_Thesis.pdf.

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This thesis defined a unique role for the protein cell division cycle associated protein-3 (CDCA3) in epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC). This thesis has established an association between the levels of CDCA3 expression and the tumour response to tyrosine kinase inhibitors (TKI), which are the front-line therapy for EGFR-mutant NSCLC. In this disease, CDCA3 functions to modulate cellular growth pathways to impact sensitivity towards TKI therapy. Future work might enable development of a clinical stratification tool to discern TKI responsive from n

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