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Articles de revues sur le sujet « Associated protein 1 (BAP) »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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1

Cucarella, Carme, M. Ángeles Tormo, Carles Úbeda, et al. "Role of Biofilm-Associated Protein Bap in the Pathogenesis of Bovine Staphylococcus aureus." Infection and Immunity 72, no. 4 (2004): 2177–85. http://dx.doi.org/10.1128/iai.72.4.2177-2185.2004.

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ABSTRACT Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to produce chronic bovine mastitis and biofilm formation. We have classified bovine mastitis S. aureus isolates into three groups based on the presence of particular genetic elements required for biofilm formation: group 1 (ica + bap +), group 2 (ica +, bap negative), and group 3 (ica negative, bap negative). Overall, animals naturally infected with group 1 and 2 isolates

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Ide, Nobuyuki, Yutake Hata, Hideo Nishioka, et al. "Localization of membrane-associated guanylate kinase (MAGI)-1/BAI-associated protein (BAP) 1 at tight junctions of epithelial cells." Oncogene 18, no. 54 (1999): 7810–15. http://dx.doi.org/10.1038/sj.onc.1203153.

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Illini, Oliver, Michal Benej, Anna Sophie Lang-Stöberl, et al. "Prognostic Value of PD-L1, BAP-1 and ILK in Pleural Mesothelioma." Journal of Clinical Medicine 13, no. 23 (2024): 7322. https://doi.org/10.3390/jcm13237322.

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Background: Pleural mesothelioma (PM) is a rare type of cancer with poor prognosis. Prognostic and predictive biomarkers could improve treatment strategies in these patients. Programmed death ligand 1 (PD-L1), integrin-linked kinase (ILK) and breast cancer gene 1-associated protein (BAP-1) have been proposed to predict outcomes in PM, but existing data are limited and controversial. Design and Methods: This single-center, retrospective study analyzed data on expression patterns and the prognostic role of PD-L1, ILK and BAP-1 in consecutive patients diagnosed with PM. Results: Of all patients (

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Liu, Lin-Quan, Xiao-Ping Huang, Ya-Hong Cai, Yan She, and Chang-Qing Deng. "Effects of nourishing qi, activating blood circulation, and inducing resuscitation on nerve cell pyroptosis after cerebral ischemia-reperfusion." Quality Assurance and Safety of Crops & Foods 15, no. 1 (2023): 193–206. http://dx.doi.org/10.15586/qas.v15i1.1237.

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Cerebral ischemia-reperfusion (CIR) is a serious complication often associated with cerebral ischemia. The purpose of this study was to explore the therapeutic effect of nourishing qi, activating blood circulation, and inducing resuscitation (Borneol with astragaloside IV and Panax notoginseng total saponins, BAP) on CIR. Neurological function score system was used to determine the neurological function. The survival of nerve cells was detected by Nissl staining. The levels of IL-1β, IL-18, IL-4, and IL-10 were detected by ELISA. The expression of GSDMD, GSDMD-N, Nrf2, and HO-1 proteins in hip

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Kitada, Shinichi, Janet Andersen, Sophie Akar, et al. "Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses." Blood 91, no. 9 (1998): 3379–89. http://dx.doi.org/10.1182/blood.v91.9.3379.

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Abstract B-cell chronic lymphocytic leukemia (B-CLL) represents a neoplastic disorder caused primarily by defective programmed cell death (PCD), as opposed to increased cell proliferation. Defects in the PCD pathway also contribute to chemoresistance. The expression of several apoptosis-regulating proteins, including the Bcl-2 family proteins Bcl-2, Bcl-XL, Mcl-1, Bax, Bak, and BAD; the Bcl-2–binding protein BAG-1; and the cell death protease Caspase-3 (CPP32), was evaluated by immunoblotting using 58 peripheral blood B-CLL specimens from previously untreated patients. Expression of Bcl-2, Mcl

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Kitada, Shinichi, Janet Andersen, Sophie Akar, et al. "Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses." Blood 91, no. 9 (1998): 3379–89. http://dx.doi.org/10.1182/blood.v91.9.3379.3379_3379_3389.

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B-cell chronic lymphocytic leukemia (B-CLL) represents a neoplastic disorder caused primarily by defective programmed cell death (PCD), as opposed to increased cell proliferation. Defects in the PCD pathway also contribute to chemoresistance. The expression of several apoptosis-regulating proteins, including the Bcl-2 family proteins Bcl-2, Bcl-XL, Mcl-1, Bax, Bak, and BAD; the Bcl-2–binding protein BAG-1; and the cell death protease Caspase-3 (CPP32), was evaluated by immunoblotting using 58 peripheral blood B-CLL specimens from previously untreated patients. Expression of Bcl-2, Mcl-1, BAG-1

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Can, Nisan Denizce, Ezgi Basturk, Tugba Kizilboga, et al. "Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation." PLOS ONE 16, no. 8 (2021): e0256640. http://dx.doi.org/10.1371/journal.pone.0256640.

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Bag-1 is a multifunctional protein that regulates Hsp70 chaperone activity, apoptosis, and proliferation. The three major Bag-1 isoforms have different subcellular localizations and partly non-overlapping functions. To identify the detailed interaction network of each isoform, we utilized mass spectrometry-based proteomics and found that interactomes of Bag-1 isoforms contained many common proteins, with variations in their abundances. Bag-1 interactomes were enriched with proteins involved in protein processing and degradation pathways. Novel interaction partners included VCP/p97; a transitio

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Nguyen, Peter, Kyle Hess, Larissa Smulders, et al. "Origin and Evolution of the Human Bcl2-Associated Athanogene-1 (BAG-1)." International Journal of Molecular Sciences 21, no. 24 (2020): 9701. http://dx.doi.org/10.3390/ijms21249701.

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Molecular chaperones, particularly the 70-kDa heat shock proteins (Hsp70s), are key orchestrators of the cellular stress response. To perform their critical functions, Hsp70s require the presence of specific co-chaperones, which include nucleotide exchange factors containing the BCL2-associated athanogene (BAG) domain. BAG-1 is one of these proteins that function in a wide range of cellular processes, including apoptosis, protein refolding, and degradation, as well as tumorigenesis. However, the origin of BAG-1 proteins and their evolution between and within species are mostly uncharacterized.

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Gulati, Shuchi, Melissa Previtera, and Primo N. Lara. "BRCA1-Associated Protein 1 (BAP-1) as a Prognostic and Predictive Biomarker in Clear Cell Renal Cell Carcinoma: A Systematic Review." Kidney Cancer 6, no. 1 (2022): 23–35. http://dx.doi.org/10.3233/kca-210006.

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BACKGROUND: The gene that encodes BRCA1-associated protein 1 (BAP1) has been reported to be dysregulated in several human cancers such as uveal melanoma, malignant pleural mesothelioma, hepatocellular carcinoma, thymic epithelial tumors, and clear-cell renal cell carcinoma (ccRCC). The gene is located on the human chromosome 3p21.3, encoding a deubiquitinase and acts as a classic two-hit tumor suppressor gene. BAP1 predominantly resides in the nucleus, where it interacts with several chromatin-associated factors, as well as regulates calcium signaling in the cytoplasm. As newer therapies conti

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Saleh, Samah I., Amira E. Soliman, and Mona A. Aboelkheir. "A study of the diagnostic and prognostic role of enhancer of zeste homolog 2 and BRCA1-associated protein 1 expression in different prostatic lesions (an immunohistochemical study)." Egyptian Journal of Pathology 44, no. 1 (2024): 48–57. http://dx.doi.org/10.4103/egjp.egjp_11_24.

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Aim To ascertain the applicability of enhancer of zeste homolog 2 (EZH2) and breast cancer gene 1 (BRCA1)-associated protein 1 (BAP-1) in the diagnosis of prostatic adenocarcinoma (PCa) as well as their correlation with different clinicopathological characteristics of PCa cases and the patients’ disease-free survival. Patient and methods This study included 10 cases of benign prostatic hyperplasia (BPH), 6 cases of high-grade prostatic intraepithelial neoplasm PIN (HGPIN), and 60 cases of PCa. Immunohistochemical staining techniques were used to evaluate the roles of EZH-2 and BAP-1 in PCa and

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Aripovsky, A. V., and V. N. Titov. "BIOLOGICALLY ACTIVE PEPTIDES IN METABOLISM REGULATION. PEPTONS, PEPTIDES, AMINO ACIDS, FATTY ACIDS, LIPOPROTEINS, LIPIDS, AND THE EFFECT OF NUTRICEUTICALS." Russian Clinical Laboratory Diagnostics 64, no. 1 (2019): 14–23. http://dx.doi.org/10.18821/0869-2084-2019-64-1-14-23.

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According to phylogenetic theory of general pathology, formation of multicellular organisms started when each cell (a unicellular organism) reached the first level of relative biological perfection. By that time the stimuli for perfection of the unicellular exhausted, and formation of the multicellular became a biological necessity. All cells, being associated, formed the second level of relative biological perfection within the principle of biological succession. The association included highly organized unicellular organisms with their specific autocrine biological functions and reactions. A

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de Koning, Leanne, Didier Decaudin, Rania El Botty, et al. "PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma." Cancers 11, no. 6 (2019): 751. http://dx.doi.org/10.3390/cancers11060751.

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Uveal melanoma (UM) remains without effective therapy at the metastatic stage, which is associated with BAP-1 (BRCA1 associated protein) mutations. However, no data on DNA repair capacities in UM are available. Here, we use UM patient-derived xenografts (PDXs) to study the therapeutic activity of the PARP inhibitor olaparib, alone or in combination. First, we show that the expression and the activity of PARP proteins is similar between the PDXs and the corresponding patient’s tumors. In vivo experiments in the PDX models showed that olaparib was not efficient alone, but significantly increased

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Zhou, Yan, Andrew C. Nelson, Yuyu He, et al. "Gene Expression and Mutational Profile in BAP-1 Inactivated Melanocytic Lesions of Progressive Malignancy from a Patient with Multiple Lesions." Genes 13, no. 1 (2021): 10. http://dx.doi.org/10.3390/genes13010010.

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BAP-1 (BRCA1-associated protein 1) inactivated melanocytic lesions are a group of familial or sporadic lesions with unique histology and molecular features. They are of great clinical interest, at least in part due to the potential for malignant transformation and association with a familial cancer predisposition syndrome. Here, we describe a patient with multiple spatially and temporally distinct melanocytic lesions with loss of BAP1 expression by immunohistochemistry. RNA sequencing was performed on three independent lesions spanning the morphologic spectrum: a benign nevus, an atypical tumo

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Yanagisawa, Masahiro, Han Hyojeong, Francisca C. Gushiken, and K. Vinod Vijayan. "Regulation of Platelet Survival by Protein Phosphatase 1 Gamma." Blood 116, no. 21 (2010): 2026. http://dx.doi.org/10.1182/blood.v116.21.2026.2026.

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Abstract Abstract 2026 Platelets are key players in hemostasis and their senescence is intrinsically associated with the activation of apoptotic pathways that shows similarities to the apoptosis of nucleated cells. Anti-apoptotic protein Bcl-xl restrains the pro-apoptotic Bak activity and maintains platelet survival in circulation. In nucleated cells, serine phosphorylation of a pro-apoptotic protein Bad can also promote cell survival. Serine phosphorylation of Bad is regulated by the action of serine/threonine (Ser/Thr) protein kinases and Ser/Thr protein phosphatases. Although alterations in

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Kim, Hwan-Young, Hye-Ran Kim, Stephanie J. Won, et al. "Protein Profiling of Hematopoietic Progenitor Cells and Leukemia Cells Identifies Novel Biomarkers Associated with Exposure of Polycyclic Aromatic Hydrocarbons." Blood 120, no. 21 (2012): 4690. http://dx.doi.org/10.1182/blood.v120.21.4690.4690.

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Abstract Abstract 4690 Background: Polycyclic aromatic hydrocarbons (PAHs) are one of the major environmental hazardous compounds in living environment generated by combustion of fossil fuels. PAHs are classified as carcinogens by International Agency for Research on Cancer. However, the study on biomarkers and biological effect of PAHs has not been thoroughly studied in peripheral blood stem cells (PBSC) and leukemia cell lines. Therefore, the present study investigated biological characteristics and biomarkers in hematopoietic cells and leukemia cell lines after exposure of PAHs. Materials a

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Bar, Daniel Z., Maya Davidovich, Ayelet T. Lamm, Hagit Zer, Katherine L. Wilson, and Yosef Gruenbaum. "BAF-1 mobility is regulated by environmental stresses." Molecular Biology of the Cell 25, no. 7 (2014): 1127–36. http://dx.doi.org/10.1091/mbc.e13-08-0477.

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Barrier to autointegration factor (BAF) is an essential component of the nuclear lamina that binds lamins, LEM-domain proteins, histones, and DNA. Under normal conditions, BAF protein is highly mobile when assayed by fluorescence recovery after photobleaching and fluorescence loss in photobleaching. We report that Caenorhabditis elegans BAF-1 mobility is regulated by caloric restriction, food deprivation, and heat shock. This was not a general response of chromatin-associated proteins, as food deprivation did not affect the mobility of heterochromatin protein HPL-1 or HPL-2. Heat shock also in

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Dkhissi, Fatima, Djamel Aggoune, Julien Pontis, et al. "BRCA1-Down-Regulation In Chronic Myeloid Leukemia (CML) Occurs Via The Deubiquitinase / Tumor Suppressor BRCA1-Associated Protein 1 (BAP1)." Blood 122, no. 21 (2013): 3813. http://dx.doi.org/10.1182/blood.v122.21.3813.3813.

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Abstract BCR-ABL has been shown to lead to a genetic instability in leukemic cells either directly by inducing oxidative stress or indirectly by compromising DNA repair mechanisms. BRCA1 is a major DNA repair gene as it promotes homologous recombination and plays thereby a critical role for preserving genomic integrity. We have previously reported that BCR-ABL down-regulates BRCA1 protein using a post-transcriptional mechanism (Deutsch et al, Blood 2003). The precise mechanism of this down regulation had not been established so far. BAP1 (BRCA1 associated protein-1) is a tumor suppressor gene

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Sharp, Adam, Simon J. Crabb, Peter W. M. Johnson, et al. "Thioflavin S (NSC71948) Interferes with Bcl-2-Associated Athanogene (BAG-1)-Mediated Protein-Protein Interactions." Journal of Pharmacology and Experimental Therapeutics 331, no. 2 (2009): 680–89. http://dx.doi.org/10.1124/jpet.109.153601.

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Barría, María Inés, Raymond A. Alvarez, Kenneth Law, Deanna L. Wolfson, Thomas Huser, and Benjamin K. Chen. "Endocytic Motif on a Biotin-Tagged HIV-1 Env Modulates the Co-Transfer of Env and Gag during Cell-to-Cell Transmission." Viruses 13, no. 9 (2021): 1729. http://dx.doi.org/10.3390/v13091729.

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During HIV-1 transmission through T cell virological synapses, the recruitment of the envelope (Env) glycoprotein to the site of cell–cell contact is important for adhesion and for packaging onto nascent virus particles which assemble at the site. Live imaging studies in CD4 T cells have captured the rapid recruitment of the viral structural protein Gag to VSs. We explored the role of endocytic trafficking of Env initiated by a membrane proximal tyrosine motif during HIV transfer into target cells and examined the factors that allow Gag and Env to be transferred together across the synapse. To

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Alhamdow, Ayman, Håkan Tinnerberg, Christian Lindh, Maria Albin, and Karin Broberg. "Cancer-related proteins in serum are altered in workers occupationally exposed to polycyclic aromatic hydrocarbons: a cross-sectional study." Carcinogenesis 40, no. 6 (2019): 771–81. http://dx.doi.org/10.1093/carcin/bgz022.

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AbstractExposure to some polycyclic aromatic hydrocarbons (PAH) increases the risk of cancer and is common particularly for workers in occupations such as chimney sweeping. In exposed workers, screening of early cancer-related markers provides important information to identify individuals at risk. Here, we aimed to elucidate the associations between PAH exposure and serum levels of cancer-related proteins in 118 chimney sweeps and 126 occupationally unexposed controls, all non-smoking males from Sweden. Monoydroxylated metabolites of pyrene, phenanthrene, benzo[a]pyrene and benzo[a]anthracene

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Shiratsuchi, Takayuki, Manabu Futamura, Katsutoshi Oda, Hiroyuki Nishimori, Yusuke Nakamura, and Takashi Tokino. "Cloning and Characterization of BAI-Associated Protein 1: A PDZ Domain-Containing Protein That Interacts with BAI1." Biochemical and Biophysical Research Communications 247, no. 3 (1998): 597–604. http://dx.doi.org/10.1006/bbrc.1998.8603.

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Agarraberes, Fernando A., and J. Fred Dice. "A molecular chaperone complex at the lysosomal membrane is required for protein translocation." Journal of Cell Science 114, no. 13 (2001): 2491–99. http://dx.doi.org/10.1242/jcs.114.13.2491.

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A group of cytosolic proteins are targeted to lysosomes for degradation in response to serum withdrawal or prolonged starvation by a process termed chaperone-mediated autophagy. In this proteolytic pathway little is known about how proteins are translocated across lysosomal membranes. We now show that an isoform of the constitutively expressed protein of the heat shock family of 70 kDa (Hsc70) is associated with the cytosolic side of the lysosomal membrane where it binds to substrates of this proteolytic pathway. Results from coimmunoprecipitation and colocalization studies indicate that this

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Perkins, D., E. F. R. Pereira, and L. Aurelian. "The Herpes Simplex Virus Type 2 R1 Protein Kinase (ICP10 PK) Functions as a Dominant Regulator of Apoptosis in Hippocampal Neurons Involving Activation of the ERK Survival Pathway and Upregulation of the Antiapoptotic Protein Bag-1." Journal of Virology 77, no. 2 (2003): 1292–305. http://dx.doi.org/10.1128/jvi.77.2.1292-1305.2003.

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ABSTRACT Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) can trigger or block apoptosis in a cell type-dependent manner. We have recently shown that the protein kinase activity of the large subunit of the HSV-2 ribonucleotide reductase (R1) protein (ICP10 PK) blocks apoptosis in cultured hippocampal neurons by activating the extracellular signal-regulated kinase (ERK) survival pathway (Perkins et al., J. Virol. 76:1435-1449, 2002). The present studies were designed to better elucidate the mechanism of ICP10 PK-induced neuroprotection and determine whether HSV-1 has similar activity. The d

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Volkmann, E., D. Tashkin, M. Leng, et al. "OP0268 TREATMENT STATUS AFFECTS HOW PULMONARY BIOMARKERS PREDICT PROGRESSION OF SYSTEMIC SCLEROSIS-RELATED INTERSTITIAL LUNG DISEASE." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 163.1–163. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1136.

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Background:The course of interstitial lung disease (ILD) varies considerably in patients with systemic sclerosis (SSc), and no biomarkers have been found to consistently predict ILD progression in this population. Treatment may affect how a candidate biomarker correlates with improvement/worsening of SSc-ILD. We hypothesized that specific proteins recovered from bronchoalveolar lavage (BAL) would differentially predict progression of SSc-ILD based on whether a patient was receiving ILD therapy.Objectives:(1) To assess the relationship between 68 unique BAL proteins measured in participants of

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Devireddy, Laxminarayana R., Kotlo U. Kumar, Mary M. Pater, and Alan Pater. "BAG-1, a novel Bcl-2-interacting protein, activates expression of human JC virus." Microbiology 81, no. 2 (2000): 351–57. http://dx.doi.org/10.1099/0022-1317-81-2-351.

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Transcription of the human polyomavirus JC virus (JCV) genome is regulated by cellular proteins and the large tumour (T) antigen. Earlier studies led to the identification of nuclear factor-1 (NF-1)-binding sites in the JCV enhancer by DNase I protection assays of extracts from retinoic acid (RA)-differentiated P19 embryonal carcinoma (EC) cells. In this study, a cDNA clone that encodes a protein capable of binding to the JCV NF-1 sites was isolated from an RA-differentiated EC cell cDNA library. Sequence analysis revealed that the cDNA isolated was identical to the previously described Bcl-2-

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Oliver, Antony W., Sarah A. Jones, Stephen Mark Roe, Steve Matthews, Graham H. Goodwin, and Laurence H. Pearl. "Crystal structure of the proximal BAH domain of the polybromo protein." Biochemical Journal 389, no. 3 (2005): 657–64. http://dx.doi.org/10.1042/bj20050310.

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The BAH domain (bromo-associated homology domain) was first identified from a repeated motif found in the nuclear protein polybromo – a large (187 kDa) modular protein comprising six bromodomains, two BAH domains and an HMG box. To date, the BAH domain has no ascribed function, although it is found in a wide range of proteins that contain additional domains involved in either transcriptional regulation (e.g. SET, PHD and bromodomain) and/or DNA binding (HMG box and AT hook). The molecular function of polybromo itself also remains unclear, but it has been identified as a key component of an SWI

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Shun, Ming-Chieh, Janet E. Daigle, Nick Vandegraaff, and Alan Engelman. "Wild-Type Levels of Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Cellular Emerin Protein." Journal of Virology 81, no. 1 (2006): 166–72. http://dx.doi.org/10.1128/jvi.01953-06.

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ABSTRACT Preintegration complexes (PICs) mediate retroviral integration, and recent results indicate an important role for the inner nuclear membrane protein emerin in orienting human immunodeficiency virus type 1 (HIV-1) PICs to chromatin for integration. Two other host cell proteins, the barrier-to-autointegration factor (BAF) and lamina-associated polypeptide 2α (LAP2α), seemed to play a similar preintegrative role for Moloney murine leukemia virus (MMLV) in addition to HIV-1. In contrast, we determined efficient HIV-1 and MMLV infection of HeLa-P4 cells following potent down-regulation of

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Fernández-Lázaro, Diego, Begoña Sanz, and Jesús Seco-Calvo. "Mechanisms of programmed cell death: structural and functional pathways. A narrative review." Investigación Clínica 65, no. 2 (2024): 230–52. http://dx.doi.org/10.54817/ic.v65n2a09.

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Apoptosis, necroptosis, and autophagy are cellular mechanisms by which cells are programmed to die under various physiological and devel-opmental stimuli. A multitude of protein mediators of programmed cell death have been identified, and apoptosis, necroptosis, and autophagy signals have been found to utilize common pathways that elucidate the proteins involved. This narrative review focuses on caspase-dependent and caspase-independent programmed cell death systems. Including studies of caspase-dependent pro-grammed cell death, extrinsic pathway apoptotic mechanisms, phosphatidyl-serine (PS),

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Casanova, Ramon, Jamie Justice, Keenan Walker, et al. "LINKING PLASMA PROTEOMICS TO BRAIN ACCELERATED/RESILIENT AGING IN THE ATHEROSCLEROSIS RISK IN COMMUNITY STUDY." Innovation in Aging 7, Supplement_1 (2023): 860. http://dx.doi.org/10.1093/geroni/igad104.2769.

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Abstract Machine learning models are increasingly being used to estimate ‘brain age’ from neuroimaging data. The gap between chronological age and the estimated brain age (BAG) is potentially a measure of accelerated/resilient brain aging, and we estimated BAG based on an elastic net regression approach. Here, we report associations between this brain age measure and plasma protein levels (measured using an aptamer-based proteomic platform) in the Atherosclerosis Risk in Communities (ARIC) Study to determine whether BAG was associated with proteins linked to biologic aging. We used brain MRI s

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Serio, Gabriella, Federica Pezzuto, Francesco Fortarezza, et al. "Mesothelioma and Colorectal Cancer: Report of Four Cases with Synchronous and Metachronous Presentation." International Journal of Molecular Sciences 23, no. 5 (2022): 2630. http://dx.doi.org/10.3390/ijms23052630.

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There is evidence that asbestos could play a role in the carcinogenesis of digestive cancers. The presence of asbestos fibres in histological samples from gastric, biliary, colon cancers has been reported, but the mechanism is still controversial. It has been hypothesised that asbestos reaches these sites, especially through contaminated water; however, some experimental studies have shown that the inhaled fibres are mobile, so they can migrate to many organs, directly or via blood and lymph flow. We report four unusual cases of colorectal cancers in patients with a long history of asbestos ex

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Lee, Moo-Seung, Rama P. Cherla, Dinorah Leyva-Illades, and Vernon L. Tesh. "Bcl-2 Regulates the Onset of Shiga Toxin 1-Induced Apoptosis in THP-1 Cells." Infection and Immunity 77, no. 12 (2009): 5233–44. http://dx.doi.org/10.1128/iai.00665-09.

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ABSTRACT Shiga toxins (Stxs), which are proteins expressed by the enteric pathogens Shigella dysenteriae serotype 1 and some serotypes of Escherichia coli, are potent protein synthesis inhibitors. Stx-producing organisms cause bloody diarrhea with the potential to progress to acute renal failure and central nervous system complications. Studies using animal models of these diseases have shown that Stxs are major virulence factors, and purified toxins have been shown to be capable of killing many types of cells in vitro. We showed that Stx type 1 (Stx1) rapidly induced apoptosis in undifferenti

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Heider, Ulrike, Martin Kaiser, Christian Müller, et al. "Treatment of Bortezomib Increases Osteoblast Function in Patients with Multiple Myeloma." Blood 106, no. 11 (2005): 3457. http://dx.doi.org/10.1182/blood.v106.11.3457.3457.

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Abstract Myeloma bone disease is caused by an enhanced osteoclast activation and impaired osteoblast function. Until now, there is no specific treatment to restore osteoblast activity, and anti-myeloma therapies that lead to a disease remission are usually not associated with an increase of osteoblast markers. Recently, preclinical data suggested that proteasome inhibitors may enhance osteoblast function. Bortezomib (Velcade) represents the first substance from this group which is clinically used in relapsed multiple myeloma. To evaluate whether there is clinical evidence for an osteoblast sti

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Looi, Chin-King, Ling-Wei Hii, Siew Ching Ngai, Chee-Onn Leong, and Chun-Wai Mai. "The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player?" Biomedicines 8, no. 9 (2020): 334. http://dx.doi.org/10.3390/biomedicines8090334.

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Metastasis is known as the most life-threatening event in cancer patients. In principle, the immune system can prevent tumor development. However, dysfunctional T cells may fail to eliminate the tumor cells effectively and provide additional survival advantages for tumor proliferation and metastasis. Constitutive activation of Ras-associated protein1 (Rap1) has not only led to T cell anergy, but also inhibited autophagy and supported cancer progression through various oncogenic events. Inhibition of Rap1 activity with its negative regulator, Rap1GAP, impairs tumor progression. However, active

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Du, Xing, Richard J. Youle, David J. FitzGerald, and Ira Pastan. "Pseudomonas Exotoxin A-Mediated Apoptosis Is Bak Dependent and Preceded by the Degradation of Mcl-1." Molecular and Cellular Biology 30, no. 14 (2010): 3444–52. http://dx.doi.org/10.1128/mcb.00813-09.

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ABSTRACT Pseudomonas exotoxin A (PE) is a bacterial toxin that arrests protein synthesis and induces apoptosis. Here, we utilized mouse embryo fibroblasts (MEFs) deficient in Bak and Bax to determine the roles of these proteins in cell death induced by PE. PE induced a rapid and dose-dependent induction of apoptosis in wild-type (WT) and Bax knockout (Bax−/−) MEFs but failed in Bak knockout (Bak−/−) and Bax/Bak double-knockout (DKO) MEFs. Also a loss of mitochondrial membrane potential was observed in WT and Bax−/− MEFs, but not in Bak−/− or in DKO MEFs, indicating an effect of PE on mitochond

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Park, Hyun, Jong Kang, and Myung Lee. "1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells." Molecules 24, no. 5 (2019): 867. http://dx.doi.org/10.3390/molecules24050867.

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1-O-Hexyl-2,3,5-trimethylhydroquinone (HTHQ) has previously been found to have effective anti-oxidant and anti-lipid-peroxidative activity. We aimed to elucidate whether HTHQ can prevent dopaminergic neuronal cell death by investigating the effect on l-DOPA-induced cytotoxicity in PC12 cells. HTHQ protected from both l-DOPA-induced cell death and superoxide dismutase activity reduction. When assessing the effect of HTHQ on oxidative stress-related signaling pathways, HTHQ inhibited l-DOPA-induced phosphorylation of sustained extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activate

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Gold, M. R., M. T. Crowley, G. A. Martin, F. McCormick, and A. L. DeFranco. "Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins." Journal of Immunology 150, no. 2 (1993): 377–86. http://dx.doi.org/10.4049/jimmunol.150.2.377.

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Abstract Cross-linking membrane Ig (mIg) on B cells stimulates tyrosine phosphorylation of proteins involved in signal transduction including the mIg-associated proteins Ig-alpha and Ig-beta, the tyrosine kinases p53/p56lyn, p55blk, p59fyn, and PTK72, phosphatidylinositol 3-kinase, phospholipase C gamma 1 and gamma 2, and the mitogen-activated protein kinase. We now show that the p21ras GTPase-activating protein (GAP) is also a substrate for mIg-activated tyrosine kinases. p21ras is a key regulator of cell growth and GAP may act as both a regulator of p21ras activity and as a downstream effect

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Uchida, Tohru, Martin G. Myers, and Morris F. White. "IRS-4 Mediates Protein Kinase B Signaling during Insulin Stimulation without Promoting Antiapoptosis." Molecular and Cellular Biology 20, no. 1 (2000): 126–38. http://dx.doi.org/10.1128/mcb.20.1.126-138.2000.

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ABSTRACT Insulin receptor substrate (IRS) proteins are tyrosine phosphorylated and mediate multiple signals during activation of the receptors for insulin, insulin-like growth factor 1 (IGF-1), and various cytokines. In order to distinguish common and unique functions of IRS-1, IRS-2, and IRS-4, we expressed them individually in 32D myeloid progenitor cells containing the human insulin receptor (32DIR). Insulin promoted the association of Grb-2 with IRS-1 and IRS-4, whereas IRS-2 weakly bound Grb-2; consequently, IRS-1 and IRS-4 enhanced insulin-stimulated mitogen-activated protein kinase acti

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Tariki, Milena Shizue, Anna Paula Carreta Ruano, Jacqueline Aparecida Torres, et al. "Dynamic and immunocytochemistry analysis of circulation tumor cells (CTCs) in blood samples from patients with advanced ccRCC starting first-line treatment in a Brazilian Cancer Center." Journal of Clinical Oncology 41, no. 6_suppl (2023): 704. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.704.

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704 Background: Treatment of advanced clear cell renal carcinoma (ccRCC) improved dramatically in the last 20 years, but biomarkers development lagged behind. Circulating tumor cell (CTC) is used as a prognostic and predictive tool in many solid tumors but is poorly studied in ccRCC. Objective: Our aim was to evaluate CTC counts in serial blood samples from patients with advanced ccRCC that started first-line treatment and analyze the protein expression of PBRM1, BAP1, PD-L1 and CD133 in these cells. Methods: Blood samples (10mL) were collected in EDTA tubes at three different timepoints, 30 d

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Peppone, L. J., K. Mustian, R. N. Rosier, et al. "The effect of tai chi chuan on bone remodeling and cytokines among breast cancer survivors: A feasibility trial." Journal of Clinical Oncology 27, no. 15_suppl (2009): 9610. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.9610.

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9610 Background: Weight-bearing exercise may slow the rate of bone loss associated with breast cancer treatment. The purpose of this study is to determine the effect of tai chi chuan (TCC) on bone health, as measured by the changes in the levels of bone resorption and bone formation. This study also aimed to investigate whether changes in bone health were correlated with growth and inflammation markers that serve as regulators of bone cell function. Methods: Female patients (N=16) who completed treatment for breast cancer within the past 30 months were randomly assigned to either the TCC group

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Hrynchuk, N. I., N. O. Vrynchanu, T. A. Buchtyarova, D. M. Dudikova, Yu V. Korotkyi, and L. B. Bondarenko. "Antibiofilm Effect of Adamantane Derivative against Staphylococcus aureus." Mikrobiolohichnyi Zhurnal 83, no. 1 (2021): 58–67. http://dx.doi.org/10.15407/microbiolj83.01.058.

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Currently, one of the most urgent problems in clinical practice is the antibiotic therapy ineffectiveness at chronic diseases treatment caused by biofilms-forming microorganisms. One of the ways to its solution is the search for new compounds with antibiofilm activity which can prevent the adhesion of microorganisms, disrupt the structure of the biofilm matrix and affect the Quorum sensing system. The aim of the study was to investigate adamantane derivative 1-[4-(1-adamantyl) phenoxy]-3-(N-benzyl,N-dimethylamino)-2-propanol chloride (KVM-97) antimicrobial activity mechanism against Staphyloco

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Hiremath, Jagadish, Basavaraj Binjawadagi, Kang Ouyang, et al. "TREM2 differential expression is associated with BAL cells that express high levels of ARG1 (VET2P.1044)." Journal of Immunology 192, no. 1_Supplement (2014): 207.16. http://dx.doi.org/10.4049/jimmunol.192.supp.207.16.

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Abstract Lung immunopathology is the major cause of influenza induced morbidity and mortality. DAP12 (DNAX-Activating Protein of 12kDa) is a membrane adaptor protein associated with varied surface receptors, and it is known to regulate influenza induced lung immunopathology. DAP12 associated receptor expression and their association with phenotype of bronchoalveolar lavage fluid (BAL) cells during swine influenza virus (SIV) infection in pigs is unknown. Since pig is a suitable large animal model for influenza research, our aim was to understand the effects of zoonotic SIV H1N1 infection on ex

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Schickel, Jörg, Katharina Stahn, Klaus-Peter Zimmer, et al. "Gene for integrin-associated protein (IAP, CD47): Physical mapping, genomic structure, and expression studies in skeletal muscle." Biochemistry and Cell Biology 80, no. 2 (2002): 169–76. http://dx.doi.org/10.1139/o01-210.

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Integrin-associated protein (IAP) is a widely expressed membrane protein with multiple functions in immunological and neuronal processes. Having physically mapped the IAP gene into a BAC/PAC contig covering approximately 1 Mb on human chromosome 3q13.1-q13.2, we determined the genomic organization of the gene, established its expression in skeletal muscle, and identified a novel splice variant. Our expression studies demonstrate expression of integrin-associated protein in the t-tubular system and the euchromatin of skeletal muscle cells where its function thus far is not known.Key words: inte

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González-Vázquez, Rosa, María Guadalupe Córdova-Espinoza, Alejandro Escamilla-Gutiérrez, et al. "Detection of mecA Genes in Hospital-Acquired MRSA and SOSA Strains Associated with Biofilm Formation." Pathogens 13, no. 3 (2024): 212. http://dx.doi.org/10.3390/pathogens13030212.

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Methicillin-resistant (MR) Staphylococcus aureus (SA) and others, except for Staphylococcus aureus (SOSA), are common in healthcare-associated infections. SOSA encompass largely coagulase-negative staphylococci, including coagulase-positive staphylococcal species. Biofilm formation is encoded by the icaADBC operon and is involved in virulence. mecA encodes an additional penicillin-binding protein (PBP), PBP2a, that avoids the arrival of β-lactams at the target, found in the staphylococcal cassette chromosome mec (SCCmec). This work aims to detect mecA, the bap gene, the icaADBC operon, and typ

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Kim, Hwan-Young, Hye-Ran Kim, Trang Nguyen Thi Dai, et al. "Profiling Of Polycyclic Aromatic Hydrocarbons-Induced Genotoxicity In Peripheral Blood Stem Cells and Bone Marrow Mesenchymal Stem Cells." Blood 122, no. 21 (2013): 1221. http://dx.doi.org/10.1182/blood.v122.21.1221.1221.

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Abstract Background Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants that are potent mutagens and classified as carcinogens by International Agency for Research on Cancer. However, genotoxic effect of PAHs exposure has not been thoroughly presented in peripheral blood stem cells (PBSC) and bone marrow-mesenchymal stem cells (BM-MSC). Therefore, this study investigated the profiling of PAHs-induced genotoxicity in hematopoietic and mesenchymal stem cells using primary human-derived PBSC and BM-MSC. Zebrafish (Danio rerio) as in vivo vertebrate model was used for m

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Schwingshackl, Andreas, Benjamin Lopez, Bin Teng, et al. "Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins." American Journal of Physiology-Lung Cellular and Molecular Physiology 313, no. 6 (2017): L1030—L1046. http://dx.doi.org/10.1152/ajplung.00121.2017.

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We previously proposed a role for the two-pore domain potassium (K2P) channel TREK-1 in hyperoxia (HO)-induced lung injury. To determine whether redundancy among the three TREK isoforms (TREK-1, TREK-2, and TRAAK) could protect from HO-induced injury, we now examined the effect of deletion of all three TREK isoforms in a clinically relevant scenario of prolonged HO exposure and mechanical ventilation (MV). We exposed WT and TREK-1/TREK-2/TRAAK-deficient [triple knockout (KO)] mice to either room air, 72-h HO, MV [high and low tidal volume (TV)], or a combination of HO + MV and measured quasist

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Furukawa, K. "LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction." Journal of Cell Science 112, no. 15 (1999): 2485–92. http://dx.doi.org/10.1242/jcs.112.15.2485.

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Lamina-associated polypeptide (LAP) 2, which directly interacts with B-type lamins and chromosomes, is an integral membrane protein specifically distributed along the inner nuclear membrane of the nuclear envelope. The chromatin- and lamin-binding activity of LAP2 suggests that LAP2 plays an important role in targeting mitotic vesicles to chromosomes and reorganizing the nuclear structure at the end of mitosis. Here I identified a LAP2 interacting protein, termed L2BP1 (LAP2 binding protein 1). The rat L2BP1 cDNA sequence is predicted to encode a protein of 89 amino acids which turns out to be

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Morales, Alejo A., David Siefker, Shannon M. Matulis, Delia M. Gutman, and Lawrence H. Boise. "Bak Binding to Bcl-xL and Not to Mcl-1 Is Associated with ABT-737 Sensitivity in Multiple Myeloma Cell Lines." Blood 112, no. 11 (2008): 3675. http://dx.doi.org/10.1182/blood.v112.11.3675.3675.

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Abstract ABT-737 is a Bad-like BH3 mimetic and an effective inhibitor of the anti-apoptotic Bcl-2 family members Bcl-2, Bcl-xL and Bcl-w, but not Mcl-1. Recent studies have shown this new drug as a promising anti-cancer agent with activity in multiple myeloma cells. The purpose of this study was to evaluate the role of Bcl-2 family members in both determining the sensitivity and the mechanism of action of ABT-737 in multiple myeloma cell lines. ABT-737, as a single agent, induced apoptosis in six myeloma cell lines, although the sensitivity was quite different among cell lines. Three cell line

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Pearce, Alicia F., and Douglas S. Lyles. "Vesicular Stomatitis Virus Induces Apoptosis Primarily through Bak Rather than Bax by Inactivating Mcl-1 and Bcl-XL." Journal of Virology 83, no. 18 (2009): 9102–12. http://dx.doi.org/10.1128/jvi.00436-09.

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ABSTRACT Vesicular stomatitis virus (VSV) induces apoptosis via the mitochondrial pathway. The mitochondrial pathway is regulated by the Bcl-2 family of proteins, which consists of both pro- and antiapoptotic members. To determine the relative importance of the multidomain proapoptotic Bcl-2 family members Bak and Bax, HeLa cells were transfected with Bak and/or Bax small interfering RNA (siRNA) and subsequently infected with recombinant wild-type VSV. Our results showed that Bak is more important than Bax for the induction of apoptosis in this system. Bak is regulated by two antiapoptotic Bcl

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Rahmani, Mohamed, Anh Anderson, Joseph Reza Habibi, et al. "The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways." Blood 114, no. 20 (2009): 4507–16. http://dx.doi.org/10.1182/blood-2008-09-177881.

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Abstract Mechanisms underlying apoptosis induced by concomitant interruption of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 (MEK/ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/Akt pathways were investigated in human leukemia cells. Inhibition of these pathways using the MEK inhibitor PD184352 or U0126 and the PI3K/Akt inhibitor perifosine strikingly induced apoptosis in multiple malignant human hematopoietic cells, and substantially reduced the colony-forming capacity of primary acute myeloblastic leukemia, but not normal CD34+ cells. These events we

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Le, Nguyen Phuong Khanh, Shankaramurthy Channabasappa, Mokarram Hossain, Lixin Liu, and Baljit Singh. "Leukocyte-specific protein 1 regulates neutrophil recruitment in acute lung inflammation." American Journal of Physiology-Lung Cellular and Molecular Physiology 309, no. 9 (2015): L995—L1008. http://dx.doi.org/10.1152/ajplung.00068.2014.

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The mechanisms of excessive migration of activated neutrophils into inflamed lungs, credited with tissue damage, are not fully understood. We explored the hitherto unknown expression of leukocyte-specific protein 1 (LSP1) in human and mouse lungs and neutrophils and examined its role in neutrophil migration in acute lung inflammation. Autopsied septic human lungs showed increased LSP1 labeling in epithelium, endothelium, and leukocytes, including in their nuclei compared with normal lungs. We induced acute lung inflammation through intranasal administration of E. coli lipopolysaccharide (LPS)

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