Bibliographies thématiques / Hemopoietic stem cells and induced pluripotent stem cells

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Littérature scientifique sur le sujet « Hemopoietic stem cells and induced pluripotent stem cells »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Articles de revues sur le sujet "Hemopoietic stem cells and induced pluripotent stem cells"

Reipert, S., J. A. Hickman, and T. D. Allen. "DNA inclusions within autolytic cytoplasmic vacuoles of hemopoietic stem cell line FDCP-Mix." Journal of Histochemistry & Cytochemistry 44, no. 6 (1996): 549–58. http://dx.doi.org/10.1177/44.6.8666740.

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FDCP-Mix, a pluripotent routine hemopoietic stem cell line undergoes internucleosomal cleavage of DNA when induced to apoptosis either by drugs or by withdrawal of growth factor (IL-3), and also displays a pattern of nuclear morphology that is typical for apoptosis. However, increased autolytic activity in the cytoplasm precedes the nuclear changes. For etoposide-treated FDCP-Mix cells, mitochondria were identified as a target for autolytic digestion in large autolytic vacuoles, but during this period an increase in the number of mitochondria was observed. The autolytic vacuoles displayed vari

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Kajigaya, S., T. Suda, J. Suda, et al. "A recombinant murine granulocyte/macrophage (GM) colony-stimulating factor derived from an inducer T cell line (IH5.5). Functional restriction to GM progenitor cells." Journal of Experimental Medicine 164, no. 4 (1986): 1102–13. http://dx.doi.org/10.1084/jem.164.4.1102.

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The cDNA for the murine granulocyte/macrophage colony-stimulating factor (GM-CSF) was cloned from a cDNA library obtained from a murine T cell line, IH5.5, by using two synthetic probes that encoded two parts of the GM-CSF from murine lung. The cDNA inserted into the plasmid vector pcDV1 was transfected into monkey COS-1 cells and the conditioned medium was used to investigate the hemopoietic activities of the resultant product, recombinant GM-CSF (rGM-CSF), by means of various colony assays. rGM-CSF stimulated only neutrophil/macrophage colonies in the cultures of murine normal bone marrow an

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Bauvois, B., S. Ezine, B. Imhof, M. Denoyelle, and J. P. Thiery. "A role for the thymic epithelium in the selection of pre-T cells from murine bone marrow." Journal of Immunology 143, no. 4 (1989): 1077–86. http://dx.doi.org/10.4049/jimmunol.143.4.1077.

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Abstract A rat thymic epithelial cell line IT45-R1 has been previously described as secreting soluble molecules that in vitro chemoattract rat hemopoietic precursor cells. The development of such an in vitro migration assay was based on the ability of cells to migrate across polycarbonate filters in Boyden chambers. In the present paper, by using the same strategy, we studied murine bone marrow cells capable of migrating in vitro toward IT45-R1 conditioned medium. The responding cells were shown to represent a minor bone marrow subpopulation characterized by a low capacity to incorporate triti

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Srinivas, G., D.V. Ramanjaneyulu, E. Muralinath, et al. "An Essential Parameters of Importance of Stem Cells in Modern Medicine Include Examples of Stem Cells Therapies in Medicine, Neuro Degenerative Diseases and Pharmacological Testing." Research and Reviews in Intensive and Critical Care Nursing 3, no. 2 (2025): 1–12. https://doi.org/10.5281/zenodo.15355227.

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<em>The goal of the multidisciplinary discipline of regenerative medicine is to restore normal function by creating, replacing, or repairing damaged or lost cells, tissues, and organs, especially during illness. By altering a patient's cells, cell-based therapies—specifically, the therapeutic use of stem cells—offer a contemporary and exciting approach to regenerative medicine that may help heal a variety of illnesses.</em>

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Prosser-Dombrowski, Alexandra, John Perry, Irina Pushel, et al. "448 Unraveling the pathogenicity of a novel variant in Diamond Blackfan anemia." Journal of Clinical and Translational Science 9, s1 (2025): 132. https://doi.org/10.1017/cts.2024.1045.

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Objectives/Goals: Diamond Blackfan anemia (DBA) is caused by loss of ribosomal proteins leading to death of red blood cell progenitors. We identified a novel heterozygous variant (c.167+769C>T) in RPL30 in a patient with DBA. We hypothesized that this variant, in a gene not previously studied in DBA, would demonstrate DBA phenotype and reveal early drivers of disease. Methods/Study Population: To study the role of our novel variant, we developed an induced pluripotent stem cell (iPSC) model, including wild type (WT) and CRISPR-edited RPL30 mutant clones. We differentiated the iPSC into hema

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Doi, H., M. Inaba, Y. Yamamoto, et al. "Pluripotent hemopoietic stem cells are c-kit." Proceedings of the National Academy of Sciences 94, no. 6 (1997): 2513–17. http://dx.doi.org/10.1073/pnas.94.6.2513.

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Liting, Song, and Goldman Emanuel. "Induced pluripotent stem cells are induced pluripotent stem cell-like cells." Journal of Biomedical Research 29, no. 1 (2015): 1. http://dx.doi.org/10.7555/jbr.29.20140166.

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Prosser, Alexandra, Irina Pushel, Chris Seidel, et al. "Stem Cell Model of Novel RPL30 Variant in Diamond Blackfan Anemia with Downregulated GATA1-HSP70 in Early Erythroid Progenitors." Blood 144, Supplement 1 (2024): 2710. https://doi.org/10.1182/blood-2024-208147.

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Introduction: Diamond Blackfan anemia (DBA) is caused by ribosomal protein gene mutations leading to increased apoptosis of erythroid progenitors. We identified a novel heterozygous variant (c.167+769C&gt;T) in the noncoding region of RPL30 in a patient diagnosed with DBA. RPL30 variants have not been reported in DBA, although the gene is predicted to be intolerant to loss of function. We hypothesized that this variant would negatively impact ribosomal biogenesis, specifically in early erythroid progenitors. Methods: To study the role of our novel variant, we developed an induced pluripote

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El-Sayes, Abdullah. "Induced Pluripotent Stem Cells." Sciential - McMaster Undergraduate Science Journal, no. 1 (November 25, 2018): 16–22. http://dx.doi.org/10.15173/sciential.v1i1.1908.

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The isolation of human embryonic stem cells in 1998 has since fueled the ideology that stem cells may eventually be used for human disease therapies as well as the regeneration of tissues and organs. The transformation of somatic cells to a pluripotent state via somatic nuclear transfer and embryonic stem cell fusion brought the scientific community nearer to understanding the molecular mechanisms that govern cellular pluripotency. In 2006, the first induced pluripotent stem (iPS) cell was reported, where a mouse somatic cell was successfully converted to a pluripotent state via transduction o

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Chang, Chia-Yu, Hsiao-Chien Ting, Ching-Ann Liu, et al. "Induced Pluripotent Stem Cells." Cell Transplantation 27, no. 11 (2018): 1588–602. http://dx.doi.org/10.1177/0963689718775406.

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Many neurodegenerative diseases are progressive, complex diseases without clear mechanisms or effective treatments. To study the mechanisms underlying these diseases and to develop treatment strategies, a reliable in vitro modeling system is critical. Induced pluripotent stem cells (iPSCs) have the ability to self-renew and possess the differentiation potential to become any kind of adult cell; thus, they may serve as a powerful material for disease modeling. Indeed, patient cell-derived iPSCs can differentiate into specific cell lineages that display the appropriate disease phenotypes and vul

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Thèses sur le sujet "Hemopoietic stem cells and induced pluripotent stem cells"

Sartori, Chiara. "Generation of ovine induced pluripotent stem cells." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6491.

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Embryonic stem cells (ESCs) are pluripotent cells derived from the early embryo and are able to differentiate into cells belonging to the three germ layers. They are a valuable tool in research and for clinical use, but their applications are limited by ethical and technical issues. In 2006 a breakthrough report described the generation of induced pluripotent stem cells (iPSCs). IPSCs are ESC-like cells generated from somatic cells by forcing the ectopic expression of specific transcription factors. This circumvents the ethical issues about the use of embryos in research and provides multiple

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Veiga, Bruno Rafael Assis da. "Induced pluripotent stem cells: tradução e terminologia." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10636.

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Mestrado em Tradução Especializada<br>Nos dias de hoje existe uma controvérsia enorme em torno do uso de células estaminais provenientes do cordão umbilical e das células estaminais de fetos. Esta é uma controvérsia com a qual os cientistas têm lidado todos os dias. Agora existe um tipo células em tudo semelhante às células estaminais, no entanto, estas não provêm de células estaminais de fetos ou do cordão umbilical, mas sim de células maduras – células da pele. De forma a conciliar a necessidade de realizar um projeto de tradução especializada com a vontade de divulgar um tema tão important

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Adams, William James. "Human Vascular Endothelium from Induced Pluripotent Stem Cells." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10816.

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The vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. The development of new human endothelial genotype-phenotype studies, personalized vascular medicine efforts and cell based regenerative therapies are limited by the unavailability of patient-specific endothelial cells. Induced pluripotent stem cells (iPSC) offer great promise as a new personalized source of endothelium; however, the reproducibility, fidelity and functionality of iPSC-der

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Sendfeld, Franziska. "Modelling Brugada Syndrome using induced pluripotent stem cells." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19557.

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Objective: Brugada Syndrome is an autosomal dominant congenital heart disease that is responsible for 20% of sudden deaths of patients with structurally normal hearts. The majority of mutations involve the cardiac sodium channel gene SCN5A and give rise to classical symptoms, which include an abnormal electrocardiogram with ST segment elevation and a predisposition to ventricular fibrillation. To date, the implantation of a cardioverter defibrillator is the only proven effective treatment of the disease. The ability to reprogram dermal fibroblasts to induced pluripotent stem (iPS) cells and to

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Morishima, Tatsuya. "Neutrophil differentiation from human-induced pluripotent stem cells." Kyoto University, 2011. http://hdl.handle.net/2433/151911.

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Sharma, Ruchi. "Generation of equine induced pluripotent stem cells from keratinocytes." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17956.

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Induced pluripotent stem cells (iPSCs) are generated by reprogramming somatic cells to an embryonic state. Therefore iPSCs represent an extremely valuable tool for modelling disease and organ toxicity, with enormous potential in veterinary medicine. Several equine diseases are currently untreatable and can result in euthanasia on medical grounds. In contrast to humans, in vitro models for cellular research in equine do not exist. Therefore it has been necessary to explore the use of stem cells in constructing cell based equine models. Pluripotent stem cell populations are of great interest in

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Shum, Carole Yick Lam. "Modelling motor neuron disease using induced pluripotent stem cells." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/modelling-motor-neuron-disease-using-induced-pluripotent-stem-cells(1686136a-d045-4edc-9439-1028b0ea47db).html.

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Amyotrophic Lateral Sclerosis (ALS) is the most common adult motor neuron disease. The majority of ALS cases are sporadic (SALS), but 10% of patients have a familial form of ALS (FALS). Mutations in Fused in Sarcoma (FUS) occur in approximately 4% of FALS and less than 1% of SALS. A hallmark feature of ALS is the degeneration of upper and lower motor neurons in the brain and spinal cord; however, the mechanism underlying this loss is not known. Studies of degenerative mechanisms have been impeded by the inaccessibility of human neural tissue. A possible solution is to use induced pluripotent s

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McLaughlin, Heather Ward. "Modeling sporadic Alzheimer's disease using induced pluripotent stem cells." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13094355.

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Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation and neuronal cell death are well-known from the post-mortem brain tissue of Alzheimer's disease patients, but research into the earliest stages of disease development is hindered by limited model systems. In this thesis, an in vitro human neuronal system was derived from induced pluripotent stem (iPS) cell lines reprogrammed from dermal fibroblasts of AD patients and ag

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BACI, DENISA. "Human induced pluripotent stem cells for skeletal muscle diseases." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2014. http://hdl.handle.net/2108/201887.

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Regenerative medicine along with tissue engineering represent two closely related fields leading promising advances for the treatment of numerous musculoskeletal diseases and injuries. Nevertheless, new efforts are urgently needed to design a successful therapeutic approach for muscular disorders, aiming at identifying a functional stem cell population and biomaterial scaffolds in which cells and growth factors could be embedded. In this context, recent studies have suggested that reprogramming of somatic cells by defined transcription factors into induced pluripotent stem cells (iPS), as sour

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Taura, Daisuke. "Induction and isolation of vascular cells from human induced pluripotent stem cells." Kyoto University, 2010. http://hdl.handle.net/2433/97941.

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Livres sur le sujet "Hemopoietic stem cells and induced pluripotent stem cells"

Yildirim, Sibel. Induced Pluripotent Stem Cells. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-2206-8.

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Sullivan, Patrick J. Induced stem cells. Nova Science, 2011.

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Sullivan, Patrick J. Induced stem cells. Nova Science, 2011.

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Nagy, Andras, and Kursad Turksen, eds. Induced Pluripotent Stem (iPS) Cells. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2119-6.

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Turksen, Kursad, and Andras Nagy, eds. Induced Pluripotent Stem (iPS) Cells. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3055-5.

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Ding, Baojin, and Yu Tang, eds. Human Induced Pluripotent Stem Cells. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3999-3.

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Zhao, Xiaoyang. Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8819-9.

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Turksen, Kursad, ed. Induced Pluripotent Stem Cells and Human Disease. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2585-9.

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Ye, Kaiming, and Sha Jin, eds. Human Embryonic and Induced Pluripotent Stem Cells. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-267-0.

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Heine, Vivi M., Stephanie Dooves, Dwayne Holmes, and Judith Wagner. Induced Pluripotent Stem Cells in Brain Diseases. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2816-5.

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Chapitres de livres sur le sujet "Hemopoietic stem cells and induced pluripotent stem cells"

Price, Jack. "Induced Pluripotent Stem Cells." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-36172-2_7013.

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van Mil, Alain, Klaus Neef, Geerthe M. Balk, Jan Willem Buikema, Joost P. G. Sluijter, and Pieter A. F. M. Doevendans. "Induced Pluripotent Stem Cells." In Clinical Cardiogenetics. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45457-9_26.

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Takahashi, Kazutoshi, and Shinya Yamanaka. "Induced Pluripotent Stem Cells." In Regenerative Medicine. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9075-1_8.

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Fakoya, Adegbenro Omotuyi John, Adekunle Ebenezer Omole, Nihal Satyadev, and Khawaja Husnain Haider. "Induced Pluripotent Stem Cells." In Handbook of Stem Cell Therapy. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2655-6_40.

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Okita, Keisuke, Kazutoshi Takahashi, and Shinya Yamanaka. "Induced Pluripotent Stem Cells." In Regenerative Medicine. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-5690-8_8.

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Zaehres, Holm. "Induced Pluripotent Stem Cells." In Essential Current Concepts in Stem Cell Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33923-4_7.

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ten Have, Henk, and Maria do Céu Patrão Neves. "Stem Cells, Induced Pluripotent." In Dictionary of Global Bioethics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-54161-3_479.

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Price, Jack. "Induced Pluripotent Stem Cells." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27772-6_7013-1.

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Im, Gun-Il. "Pluripotent Stem Cells: Embryonic/Fetal Stem Cells and Induced Pluripotent Stem Cells." In Orthobiologics. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84744-9_30.

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Actes de conférences sur le sujet "Hemopoietic stem cells and induced pluripotent stem cells"

Li, Haoran, Jiahua Shi, Huaming Chen, et al. "FDNet: Frequency Domain Denoising Network For Cell Segmentation In Astrocytes Derived From Induced Pluripotent Stem Cells." In 2024 IEEE International Symposium on Biomedical Imaging (ISBI). IEEE, 2024. http://dx.doi.org/10.1109/isbi56570.2024.10635607.

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Uchugonova, Aisada, Ana Batista, and Karsten König. "Fluorescence lifetime imaging of induced pluripotent stem cells." In SPIE BiOS, edited by Ammasi Periasamy, Peter T. C. So, and Karsten König. SPIE, 2014. http://dx.doi.org/10.1117/12.2037662.

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OKANO, HIDEYUKI. "STRATEGIES TOWARD CNS-REGENERATION USING INDUCED PLURIPOTENT STEM CELLS." In Proceedings of the 20th International Conference. PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO., 2009. http://dx.doi.org/10.1142/9781848165632_0022.

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Wang, R., P. Agrawal, T. Schlaeger, et al. "Modeling Cystic Fibrosis (CF) with Induced Pluripotent Stem Cells." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6401.

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Wang, Xinglie, Jinqi Liao, Guanghui Yue, et al. "Induced Pluripotent Stem Cells Detection via Ensemble Yolo Network." In 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2021. http://dx.doi.org/10.1109/embc46164.2021.9629744.

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Li, Y., K. C. Goldfarbmuren, C. Rios, and M. A. Seibold. "Robust and Highly Specific Generation of Human Airway Epithelial Basal Stem Cells from Induced Pluripotent Stem Cells." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2314.

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Tachizaki, Takehiro, Reiko Sakaguchi, Shiho Terada, Ken-ichiro Kamei, and Hideki Hirori. "Response of human induced pluripotent stem cells to terahertz radiation." In CLEO: Applications and Technology. OSA, 2021. http://dx.doi.org/10.1364/cleo_at.2021.jm4f.4.

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Pullano, S. A., M. Greco, S. Scalise, et al. "Characterization of Induced Pluripotent Stem Cells Using a Pyroelectric Sensor." In 2021 IEEE Sensors. IEEE, 2021. http://dx.doi.org/10.1109/sensors47087.2021.9639456.

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Abdelalim, Essam, Ahmed Abdelaal, Bushra Memon, et al. "Generation of induced pluripotent stem cells from insulin resistant Qatari patients." In Qatar Foundation Annual Research Conference Proceedings. Hamad bin Khalifa University Press (HBKU Press), 2018. http://dx.doi.org/10.5339/qfarc.2018.hbpd138.

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Rodriguez Ruiz, A., A. Ravi, S. Khoenkhoen, et al. "Increasing efficiency of alveolar type II cells generation from human induced pluripotent stem cells." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.2992.

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Rapports d'organisations sur le sujet "Hemopoietic stem cells and induced pluripotent stem cells"

Ying, Mingyao. Modeling Aggressive Medulloblastoma Using Human-Induced Pluripotent Stem Cells. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada620932.

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Chernoff, Jonathan. Induced Pluripotent Stem Cells as Potential Therapeutic Agents in NF1. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada564162.

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Donohue, Henry J., Christopher Niyibizi, and Alayna Loiselle. Induced Pluripotent Stem Cell Derived Mesenchymal Stem Cells for Attenuating Age-Related Bone Loss. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada606237.

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Donahue, Henry J. Induced Pluripotent Stem Cell Derived Mesenchymal Stem Cells for Attenuating Age-Related Bone Loss. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada581680.

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Peehl, Donna M. Identification of Epigenetic Changes in Prostate Cancer using Induced Pluripotent Stem Cells. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada580354.

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Peehl, Donna. Identification of Epigenetic Changes in Prostate Cancer Using Induced Pluripotent Stem Cells. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada544181.

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Setaluri, Vijayasaradhi. Differentiation of Neonatal Human-Induced Pluripotent Stem Cells to Prostate Epithelial Cells: A Model to Study Prostate Cancer Development. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada609443.

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พฤกษานานนท์, กำธร, รัฐจักร รังสิวิวัฒน์, ปราณี นำชัยศรีค้า, นิพัญจน์ อิศรเสนา ณ อยุธยา та ประมวล วีรุตมเสน. การศึกษาเขิงเปรียบเทียบลักษณะกายภาพและชีววิทยาโมเลกุลของเซลล์ต้นกำเนิดที่สร้างจากตัวอ่อนและเซลล์ร่างกายเพื่อนำไปใช้คลิกนิก : รายงานวิจัย. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2014. https://doi.org/10.58837/chula.res.2014.16.

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เซลล์ต้นกำเนิดจากการเหนี่ยวนำ (induced pluripotent stem cells; iPSCs) สามารถสร้างได้ จากการเหนี่ยวนำเซลล์ชนิดต่าง ๆ ของร่างกาย เซลล์ต้นกำเนิดจากการเหนี่ยวนำ มีคุณสมบัติที่สำคัญคือ สามารถแบ่งตัวได้อย่างไม่จำกัด เมื่อเลี้ยงอยู่ในสภาวะ ที่เหมาะสมในห้องปฏิบัติการและยังสามารถเปลี่ยนแปลงไปเป็นเซลล์ชนิดต่าง ๆ ในร่างกายได้ทุกชนิด ดังนั้นเซลล์ต้นกำเนิดจากการเหนี่ยวนำจึงเป็นเซลล์ที่มีลักษณะทางกายภาพและชีววิทยาโมเลกุลใกล้เคียง กับเซลล์ต้นกำเนิดที่แยกจากตัวอ่อน (embryonic stem cells; ESCs) ด้วยความสามารถดังกล่าว จึงมีความพยายามในการศึกษา เพื่อจุดประสงค์ในการนำเซลล์ต้นกำเนิดทั้งจากตัวอ่อน และจากการเหนี่ยวน

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อิศรเสนา ณ อยุธยา, นิพัญจน์, та ศักนัน พงศ์พันธุ์ผู้ภักดี. โครงการ การเปลี่ยนเซลล์ร่างกายปกติเป็นเซลล์ประสาทชนิดจำเพาะโดยจรงด้วยโปรตีนและ RNA : รายงานประจำปี 2555. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2013. https://doi.org/10.58837/chula.res.2013.13.

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โรคที่เกิดจากความผิดปกติของระบบประสารทเป็นหนึ่งในปัญหาทางสาธารณสุขที่สำคัญ มีประชากรทั่วโลกกว่าหนึ่งร้อยล้านคนที่ประสบปัญหาและส่วนใหญ่ก็ไม่สามารถรักษาให้หายขาดได้ การปลูกถ่ายเซลล์ประสารทเป็นความหวังหนึ่งที่จะสามารถนำมารักษาผู้ป่วยได้ เช่นในผู้ป่วยที่เป็นโรคพาร์กินสัน การสร้างเซลล์ประสาทชนิดโดพามิเนอร์จิก (dopaminergic neuron) ที่มีความจำเพาะต่อผู้ป่วยนั้นมีศักยภาพที่จะเป็นแหล่งของเซลล์เพื่อนำมาใช้รักษาผู้ป่วยได้ ในการศึกษาครั้งนี้ ทางกลุ่มวิจัยมีวัตถุประสงค์เพื่อสร้างเซลล์ประสาทชนิดโดพามิเนอร์จิกโดยตรงจากเซลล์ dermal fibroblasts และ patient specific induced pluripotent stem cells (psiPSCs) ของ

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