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Littérature scientifique sur le sujet « Periodontal ligament »

Auteur : Grafiati

Publié le 4 juin 2021

Mis à jour le 9 juin 2025

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Articles de revues sur le sujet "Periodontal ligament"

Bahirrah, Siti, Lidya Irani Nainggolan, and Philiph Pasaribu. "Effect of Vitamin C on Tooth Movement in Terms of Periodontal Ligament Space in Guinea Pigs." Dentika Dental Journal 22, no. 2 (October 22, 2019): 39–43. http://dx.doi.org/10.32734/dentika.v22i2.1677.

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Periodontal ligaments are one of the supporting tissues of teeth that undergo remodeling during the tooth movement process. Vitamin C deficiency inhibits the regeneration of collagen fibers, which are important in tissue remodeling that affects the widening of the periodontal ligament space during the process of tooth movement. The widening of periodontal ligament space can be seen by taking radiographic photos. The purpose of this study was to determine the width of the periodontal ligament space of guinea pigs by administering vitamin C, without vitamin C, and the differences between the two groups. Those samples were grouped into four groups with observation times of 1, 4, 7, and 10 days, and each group consisted of the control group and vitamin C group. Those samples were paired with orthodontic separator rubber. After the specified time was completed, periapical radiographs were taken, and the width of the periodontal ligament space was measured by using Image J software. The mean width of the periodontal ligament space in the vitamin C group was smaller than the control group. Based on this study, it can be concluded that vitamin C has an effect on reducing periodontal ligament space in the process of tooth movement.  Key words: periodontal ligament space, vitamin C, tooth movement, remodeling

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Saito, A., E. Saito, M. Kawanami, and A. Shimada. "Healing in Transplanted Teeth with Periodontal Ligament Cultured In Vitro." Cell Transplantation 12, no. 5 (July 2003): 519–25. http://dx.doi.org/10.3727/000000003108747082.

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Regeneration of connective tissue attachment is the ultimate goal of periodontal therapy. It has been suggested that periodontal ligament cells possess the potential to create new connective tissue attachment. However, as cells from gingiva and alveolar bone occupy the root surface during initial wound healing, population by periodontal ligament cells is limited in vivo. We have been developing a new periodontal regeneration technique using in vitro tissue culture of periodontal ligament remaining on a periodontally involved root. The purpose of this study was to examine the periodontal healing after transplantation of teeth with reduced periodontal ligament that had been cultured in vitro. Twenty-five incisors from four beagles were used. After the teeth were extracted, the periodontal ligament and cementum were removed from coronal part of the roots and the roots were planed. The periodontal ligament of the apical part was retained. Fourteen teeth of the experimental group were transplanted following culture for 6 weeks. Eleven teeth of the control group were similarly prepared and immediately transplanted without tissue culture. Four weeks after transplantation, the specimens were prepared for histological analysis. Downgrowth of junctional epithelium on the root of experimental group was significantly less than control. Most of the root planed surfaces of experimental group were covered with periodontal ligament fibers oriented parallel or inclined to the root surfaces and limited new cementum formation was observed near the apical end of the planed root. There was no significant difference between groups in observations on the root surface with remaining periodontal ligament. From the above results, it was concluded that periodontal tissue culture of teeth with root planed surface and remaining periodontal ligament could reduce the extent of epithelium downgrowth and increase connective tissue adhesion on the root planed surface, as well as minimize damage to remaining periodontal ligament, after transplantation of teeth.

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Sena, K., Y. Morotome, O. Baba, T. Terashima, Y. Takano, and I. Ishikawa. "Gene Expression of Growth Differentiation Factors in the Developing Periodontium of Rat Molars." Journal of Dental Research 82, no. 3 (March 2003): 166–71. http://dx.doi.org/10.1177/154405910308200304.

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Growth and differentiation factors (GDF) 5, 6, and 7 are known to play roles in tendon and ligament formation, and are therefore probably involved in the formation of periodontal ligament. In this study, we sought to determine temporal and spatial expression of GDF-5, -6, and -7 mRNA in developing periodontal tissue of rat molars using in situ hybridization. GDF gene expression in the periodontal ligament was first detected in cells associated with the initial process of periodontal ligament fiber bundle formation. Gene signals were also detected in cells located along the alveolar bone and cementum surfaces, the insertion sites of periodontal ligaments, during the course of root formation. GDF expression in these cells were down-regulated after completion of root formation. Our results appeared to suggest the involvement of GDF-5, -6, and -7 in the formation of the dental attachment apparatus.

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Gopinathan, Gokul, Xianghong Luan, and Thomas G. H. Diekwisch. "Epigenetic Repression of RUNX2 and OSX Promoters Controls the Nonmineralized State of the Periodontal Ligament." Genes 14, no. 1 (January 12, 2023): 201. http://dx.doi.org/10.3390/genes14010201.

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The nonmineralized state of the mammalian periodontal ligament is one of the hallmarks of vertebrate evolution as it provides resilient and nontraumatic tooth anchorage for effective predation. Here we sought to determine how the chromatin state of key mineralization gene promoters contributes to the nonmineralized periodontal ligament in the midst of fully mineralized alveolar bone and cementum anchor tissues. In developing mouse periodontal tissues, RUNX2 was localized to alveolar bone–lining cells, while OSX was localized throughout the periodontal ligament’s soft tissue. Matching RT-PCR amplification data and western blot comparisons demonstrated that the expression of RUNX2 and OSX bone mineralization transcription factors was at least 2.5-fold elevated in alveolar bone osteoblasts versus periodontal ligament fibroblasts. ChIP enrichment data along the RUNX2 and OSX promoters revealed increased H3K4me3 marks in alveolar bone osteoblasts, while H3K9me3 and H3K27me3 marks were elevated in periodontal ligament fibroblasts. In support of an epigenetic mechanism responsible for the inhibition of mineralization gene expression in periodontal progenitors, histone methylation inhibitors DZNep and Chaetocin reactivated RUNX2 and OSX expression in periodontal progenitors and increased alkaline phosphatase and Alizarin Red, while the in vivo application of DZNep in rat maxillae resulted in aberrant mineralization in the periodontal ligament and a narrowing of the nonmineralized periodontal space. Together, these studies demonstrate that the nonmineralized state of the mammalian periodontal ligament is controlled by an epigenetic regulation of the RUNX2 and OSX key mineralization gene promoters.

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Brahmanta, Arya, Sutjipto Sutjipto, and Ida Bagus Narmada. "Histological changes during orthodontic tooth movement due to hyperbaric oxygen therapy." Dental Journal (Majalah Kedokteran Gigi) 49, no. 2 (February 14, 2017): 63. http://dx.doi.org/10.20473/j.djmkg.v49.i2.p63-66.

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Background: Mechanical force of orthodontics causes changes in periodontal ligament vascularization and blood flow, resulting in biochemical and cellular changes as well as changes in the contour of the alveolar bone and in the thickness of the periodontal ligaments. Hyperbaric oxygen (HBO) therapy is one of many solutions stimulating the growth of new blood vessels and increasing tissue oxygenation. Thus, HBO plays a role in recovery of periodontal ligament and osteoblasts. Purpose: This study aimed to determine the effects of HBO therapy for seven days on periodontal ligament size and osteoblast number in the tension site during bone remodeling in tooth movement. Method: The study was true experimental laboratories with completely randomized control group post test only design. Twenty-four males guinea pigs were randomly divided into three groups. K0 was the control group without any treatment, K1 was the group given a mechanical orthodontic pressure, and K2 was the group treated with the addition of hyperbaric oxygen therapy. The maxillary incisors were moved distally by elastic separator. After HBO therapy on day 7, all of the groups were sacrificed, and then periodontal ligament size and osteoblast number were analyzed by one-way Anova and LSD statistical tests. Result: The results showed significant differences in the size of the periodontal ligament and the number of osteoblasts in the tension site among the groups (p<0.05). Conclusion: HBO therapy at 2.4 ATA for 7 days is effective in recovery of periodontal ligament and increased osteoblast number during bone remodeling in tension area of orthodontic tooth movement.

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Bosiakov, Sergei, and Gennadi Mikhasev. "MATHEMATICAL MODEL FOR ANALYSIS OF TRANSLATIONAL DISPLACEMENTS OF TOOTH ROOT." Mathematical Modelling and Analysis 20, no. 4 (July 20, 2015): 490–501. http://dx.doi.org/10.3846/13926292.2015.1068877.

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Analytical modeling of stress-strain state of a periodontal ligament in the case of the translational displacement of a tooth root was carried out. The tooth root was assumed as a rigid body. The boundary conditions corresponding to the translational displacement of the root and fixed external surface of the periodontal ligament in the dental alveolus were considered. The system of differential equations describing the periodontal ligament’s plane-strain state induced by the translational motion of the tooth were used as the governing equations. An analytical solution was found for the governing equations in the explicit form. Comparative analysis of the concentrated force generated by the prescribed translational motion of the tooth root was performed using the obtained analytical solution and the model of an incompressible periodontal ligament in the form of a circular paraboloid and hyperboloid. The mathematical model developed in this paper can be used to analyze stresses and strains in the periodontal tissue during orthodontic movement.

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Aditya, Vangara, and Kharidhi Laxman Vandana. "Management of endo-perio lesion with autologous stem cell therapy." Saudi Journal of Oral Sciences 11, no. 1 (January 2024): 54–59. http://dx.doi.org/10.4103/sjoralsci.sjoralsci_79_23.

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The objective of periodontal therapy is the regeneration of tooth-supporting tissues. Various treatment modalities, such as the use of bone grafting materials, guided tissue regeneration, and delivery of enamel matrix derivatives or growth factors, are applied with large variability in regenerative outcomes. However, a case report was done by utilization of autologous dental pulp stem cells and periodontal ligament stem cell niches in the treatment of bone loss associated with endodontically and periodontally involved teeth. An autologous periodontal ligament stem cells niche adherent to the root and dental pulpal stem cells from dental pulp directly into the selected osseous defect following extraction of the impacted tooth in the same patient. The results of this case reported that the dental pulpal stem cells and periodontal ligament stem cells niche with gelatin sponge resulted in a significant amount of bone fill and reduction in probing pocket depth.

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Pinheiro, Gabriela Veloso Vieira da Silva, Robinson Sabino-Silva, Melissa Rodrigues de Araujo, Shaiene Patrícia Gomes, Stephanie Wutke Oliveira, Emília Maria Gomes Aguiar, Léia Cardoso-Sousa, Carla Castiglia Gonzaga, and Marcela Claudino. "Experimental Acute Sepsis Reduced Number of Osteocalcin Immunolabeled Cells in Periodontal Ligament." Brazilian Dental Journal 31, no. 2 (April 2020): 143–51. http://dx.doi.org/10.1590/0103-6440202003024.

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Abstract The aim of this study was to evaluate the effect of acute sepsis in the periodontal ligament, alveolar and furcation bone in absence of periodontitis induction through histological and immunohistochemical analyses. A septic rat model was established by cecal ligation and puncture (CLP). Twelve rats were randomly divided into CLP (n=6) and Sham (n=6) groups. The animals were euthanized at 24 h and hemimandibles were submitted to histomorfometric (bone matrix, collagenous fibers, fibroblasts, osteocytes, inflammatory cells, and blood vessels) and immunohistochemical (BMP-2/4, RANKL and osteocalcin) evaluation in alveolar bone, furcation bone and periodontal ligament. Our results demonstrated that histomorphometric parameters were similar in alveolar bone, furcation bone and periodontal ligament of Sham and CLP rats. Regarding to immunohistochemical analyses, the number of BMP-2/4 and RANKL immunolabeled cells was also similar in both groups. Furthermore, it was detected a reduction in the osteocalcin immunolabeled cells in periodontal ligaments of CLP compared to Sham rats (p=0.0014). In conclusion, the acute sepsis induction resulted in reduced number of osteocalcin labelled cells in periodontal ligament region. Moreover, no significant histological differences were observed in the periodontium of rats under acute sepsis. Considering the role of osteocalcin in bone remodeling, the study contributes to revealing the importance of careful periodontal evaluation in the presence of sepsis.

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Ashrafi, Mehran, Farzan Ghalichi, Behnam Mirzakouchaki, and Iman Zoljanahi Oskui. "Numerical simulation of hydro-mechanical coupling of periodontal ligament." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 234, no. 2 (November 13, 2019): 171–78. http://dx.doi.org/10.1177/0954411919887071.

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Orthodontic tooth movement in the alveolar bone is due to the mechanical response of periodontal ligament to applied forces. Definition of a proper constitutive model of the periodontal ligament to investigate its response to orthodontic loading is required. For this purpose, a three-dimensional finite element model of incisor tooth, periodontal ligament, and bone was built utilizing the hydro-mechanical coupling theory. Tooth displacement in response to orthodontic loading was then investigated, and the effect of different mechanical behaviors assigned to the solid phase of the periodontal ligament was compared. Results showed that where the periodontal ligament was placed in tension, pore volume was filled with fluid intake from the bone, but fluid flow direction was from the periodontal ligament toward the bone where the periodontal ligament was placed in compression. Because of the existence of interaction between solid and fluid phases of the periodontal ligament, considering biphasic material formulation was capable to address its microscopic behavior as well as time-dependent and large deformation behaviors. This article provides beneficial biomechanical data for future dental studies in determination of optimal orthodontic force.

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Anneroth, G., K. H. Danielsson, H. Evers, K. G. Hedström, and Å. Nordenram. "Periodontal ligament injection." International Journal of Oral Surgery 14, no. 6 (December 1985): 538–43. http://dx.doi.org/10.1016/s0300-9785(85)80061-2.

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Plus de sources

Thèses sur le sujet "Periodontal ligament"

Silva, Guilherme Ferreira da [UNESP]. "Reação histológica do periodonto, subjacente à região de furca perfurada e preenchida com diferentes materiais, em molares de ratos." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/90414.

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Made available in DSpace on 2014-06-11T19:24:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-08-12Bitstream added on 2014-06-13T20:31:51Z : No. of bitstreams: 1 silva_gf_me_arafo.pdf: 11965708 bytes, checksum: 569274cdbc2fa1d75e754bdc37d497c5 (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) O sucesso do tratamento de dentes com perfurações de furca está diretamente relacionado ao tipo de material utilizado no preenchimento destas perfurações. Um material selador ideal deve possuir boas propriedades físicas, químicas e biológicas, sendo, o Mineral Trióxido Agregado (MTA) um dos materiais indicados. Assim, o objetivo desse estudo foi avaliar a resposta biológica de três materiais seladores: MTA-Angelus branco® (MTA), Endo-C.P.M.-Sealer® (CPM) e cimento de óxido de zinco e eugenol (OZE). Para isso, foram utilizados os primeiros molares superiores de 60 ratos; o primeiro molar superior do lado esquerdo hígido foi utilizado como controle e o do lado direito foi realizada a perfuração no assoalho da câmara pulpar com uma fresa nº ¼. Os materiais foram manipulados e inseridos na perfuração e a cavidade de acesso foi selada com ionômero de vidro. Decorrido os períodos de 07, 15, 30 e 60 dias, os animais foram sacrificados e os fragmentos das maxilas removidos e fixados em formaldeído. Após a descalcificação em EDTA, os fragmentos de maxila foram desidratados, diafanizados e incluídos em parafina. Os cortes foram corados com hematoxilina & eosina (H&E), tricrômico de Masson ou submetidos ao método do TRAP (“Tartrate Resistant Acid Phosphatase”) para realização das análises morfológica e morfométrica. A análise morfométrica foi realizada sob três parâmetros: espessura do ligamento periodontal (LP), número de células inflamatórias/mm2 (CI) e número de osteoclastos TRAP-positivos. Os resultados morfométricos revelaram aumento significante (p_0,05) no espaço do LP,em todos os períodos, em relação ao controle. Entretanto, aos 60 dias, este espaço foi menor em todos os grupos experimentais; o OZE foi o que provocou maior espessamento do LP, não havendo diferenças significantes... The therapy success in the treatment of root perforations depends on the material used to fill them. The best sealing material should present good physical, chemical and biological properties. More recently, the mineral trioxide aggregate (MTA) has been indicated for sealing of root perforations. Thus, the aim of the present study was to evaluate the biological response of three sealing materials: White MTA-Angelus (MTA), Endo- C.P.M.-Sealer (CPM) and zinc-oxide and eugenol cement (OZE). Sixty adult rats weighing 250g were divided into three groups: MTA, CPM and OZE. Furcal perforations were performed in maxillary first molars with a round bur no. ¼; the contra-lateral maxillary first molars – without perforations - were used as control. The perforations were carried out and the materials were placed into these defects; access cavities were sealed with glass ionomer. After 07, 15, 30 and 60 days, the animals were killed, and fragments of maxilla containing first molars were removed and immediately immersed in 4% formaldehyde. After decalcification in EDTA, the specimens were processed and embedded in paraffin. Sections were stained with hematoxylin-eosin, Masson’s trichrome and submitted to TRAP (Tartrate Resistant Acid Phosphatase) reaction. The morphometric analysis, in the furcation region of the periodontal ligament, was performed considering three parameters: thickness of periodontal ligament (PL), number of inflammatory cells (IC) and number of TRAP-positive osteoclasts in the alveolar bone surface. The experimental groups showed, in all periods, significant increase (p_0.05) in the PL thickness in comparison to control group; this thickness was more accentuated in the OZE group. The periodontal space in the CPM group was less thick in all experimental periods in comparison to MTA and OZE groups, except in the period of 60 days; in this period, statistical differences in the periodontal space were not detected between CPM and MTA groups.

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Sousa, Hugo Alexandre de [UNESP]. "Avaliação microscópica do efeito de diferentes meios de conservação sobre o ligamento periodontal de dentes humanos extraídos cirurgicamente." Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/101071.

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Made available in DSpace on 2014-06-11T19:31:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2004Bitstream added on 2014-06-13T20:41:20Z : No. of bitstreams: 1 sousa_ha_dr_araca.pdf: 1664411 bytes, checksum: 8fb8470dab0600cadc30a00a2b17662b (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Not available.

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Sousa, Hugo Alexandre de. "Avaliação microscópica do efeito de diferentes meios de conservação sobre o ligamento periodontal de dentes humanos extraídos cirurgicamente /." Araçatuba : [s.n.], 2004. http://hdl.handle.net/11449/101071.

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Pedrini, Denise. "Análise do conhecimento dos cirurgiões dentistas sobre plano de tratamento das injúrias do ligamento periodontal após traumatismo dentoalveolar /." Araçatuba, 2008. http://hdl.handle.net/11449/106717.

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Resumo: O diagnóstico preciso e a elaboração de um plano de tratamento adequado podem constituir uma tarefa bastante complexa, especialmente nos traumatismos dentoalveolares, pois necessitam de uma abordagem multidisciplinar e conhecimento sobre o processo de reparo após o traumatismo. O objetivo do trabalho foi analisar o conhecimento dos cirurgiões dentistas sobre plano de tratamento das injúrias do ligamento periodontal após traumatismo dentoalveolar. Para tanto, a partir de um questionário, foram abordadas perguntas referentes ao perfil dos profissionais entrevistados e conduta frente às injúrias do ligamento periodontal (concussão, subluxação, luxação extrusiva, luxação lateral e luxação intrusiva) ocasionadas por traumatismo dentoalveolar. Seiscentos e noventa e três cirurgiões dentistas que participaram da 23ª Reunião Anual da SBPqO (2006) responderam o questionário e os dados obtidos foram submetidos à análise descritiva, enquanto o teste estatístico foi aplicado para demonstrar as freqüências e o nível de significância entre as variáveis (Teste qui-quadrado ou Teste Exato de Fisher). De acordo com os resultados obtidos, grandes dificuldades foram encontradas com relação ao plano de tratamento das luxações extrusiva, lateral e intrusiva. De maneira geral, a especialidade não influenciou na elaboração de planos adequados para as injúrias mais complexas. Foi possível concluir que os cirurgiões dentistas não apresentam conhecimento suficiente para tratar de maneira adequada as injúrias mais severas do ligamento periodontal após traumatismo dentoalveolar Abstract: An accurate diagnosis and the establishment of an adequate treatment plan may constitute quite a complex task, particularly in cases of dentoalveolar trauma, which require a multidisciplinary approach and knowledge of the repair process in tooth injuries. The aim of this study was to analyze the dentists' knowledge of the treatment plan for periodontal ligament injuries after dentoalveolar trauma. For such purpose, a questionnaire was prepared with questions arguing about the profile of the interviewed professionals and their conduct facing periodontal ligament injuries (concussion, subluxation, extrusive luxation, lateral luxation and intrusive luxation) secondary to dentoalveolar trauma. Six hundred and ninety three dentists attending the 23rd Annual Meeting of the SBPqO (2006) filled out the questionnaire and the obtained data were subjected to descriptive analysis. Either chi-square test or Fisher's exact test was applied to determine the frequencies and the significance level among the variables. The results revealed great difficulties in establishing a treatment plan for extrusive, lateral and intrusive luxations. In general, the dental specialty of the participants did not influence the elaboration of adequate treatment plans for the most severe injuries. It could be concluded that dentists do not have sufficient knowledge to treat properly the most severe types of periodontal ligament injuries following a dentoalveolar trauma

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Esper, Helen Ramon [UNESP]. "Remoção mecânica do ligamento periodontal cementário necrosado com escova de Robinson e pedra pomes e com lâmina de bisturi. Análise histomorfométrica e MEV." Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/88929.

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Made available in DSpace on 2014-06-11T19:23:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2004Bitstream added on 2014-06-13T19:09:42Z : No. of bitstreams: 1 esper_hr_me_araca.pdf: 903917 bytes, checksum: 93df3a7c105f3e9a41fb0a7b59b00e1e (MD5) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Um dos fatores importantes no sucesso do reimplante dentário tardio parece ser dependente do tipo de tratamento da superfície radicular. Esse tratamento inclui a remoção do ligamento periodontal cementário necrótico que pode favorecer o aparecimento das reabsorções radiculares externas, maior causa da perda dos dentes reimplantados nessas condições. O objetivo desse estudo foi comparar a efetividade de duas técnicas de remoção mecânica do ligamento periodontal cementário necrosado e a preservação da camada de cemento. Foram utilizadas 45 raízes de pré-molares hígidos extraídos com finalidade ortodôntica. Após a extração os dentes permaneceram por um período de uma hora em meio ambiente e passado esse tempo foram imersos em soro fisiológico por mais dez minutos. A partir desse passo foram divididos em 3 grupos experimentais. Grupo 1: controle, o ligamento periodontal cementário foi mantido. Grupo 2: remoção do ligamento periodontal cementário por meio de raspagem com lâmina de bisturi (RLB). Grupo 3: remoção do ligamento periodontal cementário por meio de escova de Robinson montada em baixa rotação e pasta de pedra pomes e água (RER). Após processamento das peças foram feitos cortes transversais e longitudinais nessas raízes para análise em microscopia óptica e eletrônica de varredura (MEV). Pela análise qualitativa e quantitativa dos resultados concluiu-se que a técnica RER foi mais eficiente que a RLB quanto à remoção do ligamento periodontal cementário, porém ambas preservaram a camada de cemento. One of the important features related to the success of delayed tooth replantation seems to depend on the type of root surface treatment. This treatment encloses the removal of necrotic cemental periodontal ligament, which may favors the occurrence of external root resorptions that are the major cause of loss of teeth replanted in such conditions. The aim of this study was to compare the effectiveness of two techniques for mechanical removal of necrotic cemental periodontal ligament and the preservation of the cementum layer. Forty-five roots of sound premolars extracted for orthodontic purposes were selected. After extraction, the teeth were maintained at room ambient conditions for 1 hour and then immersed in saline for additional 10 minutes. Afterwards, the roots were assigned to three experimental groups. Group 1: control, the cemental periodontal ligament was maintained. Group 2: removal of the cemental periodontal ligament by scaling with a scalpel blade (SBR). Group 3: removal of the cemental periodontal ligament using a Robinson bristle brush, at low-speed, with pumice/water slurry (RBR). After processing of the pieces, the roots were sectioned transversally and longitudinally and the specimens obtained were examined under optical and scanning electron microscopy (SEM). The quantitative and qualitative analyses of the results showed that the RBR technique was more effective than the SBR technique, as regards the removal of the cemental periodontal ligament. Both techniques preserved the cementum layer.

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Guilherme, Armando Jose Venturi. "Avaliação histologica do ligamento periodontal de ratos wistar sob efeito do hipotireoidismo agudo induzido pelo metimazol (Tapazol 'Marca Registrada')." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313461.

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Orientadores: Norair Salviano dos Reis, Antonio de Azevedo Barros Filho Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas Made available in DSpace on 2018-08-07T02:20:30Z (GMT). No. of bitstreams: 1 Guilherme_ArmandoJoseVenturi_M.pdf: 3870471 bytes, checksum: a528b13bc51100e1fb5739da61756961 (MD5) Previous issue date: 2006 Resumo: Objetivo ¿ Avaliar o ligamento periodontal sob o efeito do hipotireoidismo induzido agudamente. Métodos ¿ Foram utilizados 40 ratos wistar, que foram divididos em 2 grupos de 20 animais cada. O primeiro grupo denominado tratado, ou seja, foi induzido ao hipotireoidismo pela administração de metimazol 5 mg/100ml na água de bebida à vontade e o segundo de controle, onde não foi administrado o metimazol. A condição da tiróide foi avaliada por dosagens de T4 no plasma, pelo método de eletroquimioluminescência, de sangue colhido da veia da cauda. Cada grupo foi subdividido em impedido e desimpedido quanto ao processo de erupção e novamente subdivido, em relação a eutanásia e coleta do material, em 21 e 28 dias. Como o rato, apresenta o crescimento contínuo dos incisivos inferiores, o desimpedimento foi efetuado sob efeito anestésico através do corte do incisivo inferior esquerdo em nível da papila interdental a cada dois dias, esse processo de corte leva a erupção acelerada do dente. No 21º e 28º dia procedeu-se a eutanásia por indução anestésica e a coleta de material para análise histológica qualitativa e quantitativa onde foram tomados como parâmetros a celularidade; quantidade e aspectos das fibras colágenas e espaços vazios. Resultados ¿ A análise qualitativa do material histológico revelou diferenças entre todos os grupos. Com relação a análise quantitativa, houve diferença estatisticamente significativa com relação ao número de fibroblastos na região 5 entre os grupos controle impedido e tratado desimpedido, com relação ao espaço vazio, a diferença ocorreu entre grupos controle desimpedido e tratado desimpedido. Quando avaliada a condição de erupção acelerada foram encontradas diferenças significativas entre os grupos controle impedido e controle desimpedido, e não foram encontradas diferenças entre os grupos tratado impedido e tratado desimpedido, demonstrando assim que o hipotireoidismo é uma condição sistêmica que inibe ou minimiza os efeitos do desimpedimento na aceleração da erupção dental. Conclusão - Todos os grupos apresentaram diferenças morfológicas quando observados à microscopia. As alterações encontradas são mais dependentes da capacidade funcional das células envolvidas do que do aumento ou diminuição das mesmas. Os efeitos do hipotireoidismo parecem impedir ou minimizar os efeitos do desimpedimento no estímulo do aumento de velocidade de erupção dental Abstract: Objective ¿ Evaluate the periodontal ligament under the effect of the acutely induced hypothyroidism. Methods ¿ It was used 40 Wistar rats, which were separated in 2 groups of 20 animals each. The first group called 'treated¿, that is, was induced to the hypothyroidism by the administration of methymazole 5 mg/100ml in the drinking water at will and the second one called 'control¿ in which it was not administered the methymazole. The thyroid condition has been evaluated by dosages of T4 in plasma, by the method of electrochemoluminescence of blood collected from the tail¿s vain. Each group has been subdivided in impeded and unimpeded in relation to the eruption process and again subdivided, in relation to the euthanasia and collection of the material, in 21 and 28 days. As the rat presents the continuous grouth of the inferior incisors, the umpededing has been done under anesthetic effect by the cut of the left inferior incisor at the level of the interdental papillae each two days, this process of cut takes to the accelerated eruption of the tooth. In the 21st and 28th days it was done the euthanasia by anesthetic induction and the collection of material qualitative and quantitative histological analysis in which it was taken as parameters the cellularity; quantity and aspects of the collagen fibers and empty spaces. Results ¿ The qualitative analysis of the histological material has revealed differences among all the groups. Concerning to the quantitative analysis, there was difference statistically significant in relation to the number of the fibroblasts in region 5 between the impeded control and unimpeded treated groups, concerning to the empty space, the difference happened between the impeded control and unimpeded treated groups. When evaluated the condition of accelerated eruption it was found significant differences between the impeded control and unimpeded control groups, and it was not found differences between the impeded treated and unimpeded treated groups, showing this way that the hypothyroidism is a systemic condition that inhibits or minimizes the effects of the unimpeded in the acceleration of the dental eruption. Conclusion - All the groups have presented morphological differences when observed the microscopy. The alterations found are more dependent of the functional capacity of the involved cells than the increase or decrease of them. The effects of the hypothyroidism seem to inhibit or minimize the effects of the unimpeded in the stimulus of the increase of dental eruption speed. Mestrado Pediatria Mestre em Saude da Criança e do Adolescente

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Vasconcelos, Daniel Fernando Pereira. "Efeito da administração intermitente do fragmento 1-34 do hormonio paratireoideo em defeito fenestrado na mandibula de ratos : analise histomorfometrica." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288498.

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Orientadores: Pedro Duarte Novaes, Marcelo Rocha Marques Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba Made available in DSpace on 2018-08-13T11:15:57Z (GMT). No. of bitstreams: 1 Vasconcelos_DanielFernandoPereira_D.pdf: 3147772 bytes, checksum: f14ddeae900959b567ea4b605c927b8b (MD5) Previous issue date: 2008 Resumo: A administração intermitente de hormônio paratireóideo (PTH) é capaz de promover anabolismo ósseo, favorecendo a neoformação óssea em condições como osteoporose e reparo de fraturas. Sabendo-se que tanto os tecidos ósseos mandibulares e alveolares como os tecidos periodontais podem responder à administração de PTH de forma intermitente, o objetivo deste estudo foi avaliar histomorfometricamente o efeito da administração de PTH (1-34) em um modelo de defeito periodontal, do tipo fenestrado, na mandíbula de ratos. Foram utilizados neste estudo 32 ratos Wistar machos, com o objetivo de expor a região vestibular da raiz distal do primeiro molar inferior direito. A criação do defeito possibilitou a remoção parcial de ligamento periodontal e do cemento dentário. Após a cirurgia os animais foram separados aleatoriamente em 4 grupos (n=8): Grupo C14: administração intermitente (3 vezes por semana) do veículo de diluição do PTH por 14 dias; Grupo P14: administração intermitente de PTH (1-34) por 14 dias; Grupo C21: injeções intermitentes do veículo de diluição do PTH por 21 dias; Grupo P21: injeções intermitentes de PTH por 21 dias. Os animais foram mortos e preparados para avaliação histomorfométrica dos seguintes parâmetros: I - extensão inicial do defeito, II - extensão do defeito remanescente, III - área do defeito ósseo remanescente, IV - densidade do osso neoformado, V - área do calo formado e marcação para TRAP, VI - área do cemento neoformado, VII - análise do retardo óptico (birrefringência) do ligamento periodontal reinserido sobre a raiz operada. A análise intergrupo demonstrou que os defeitos tinham tamanhos similares inicialmente e que a administração de PTH reduziu significativamente (p<0,05) a extensão e a área do defeito remanescente. Além disso, o PTH aumentou significativamente (p<0,05) a densidade do osso neoformado, a área do calo, o número de osteoclastos presentes no calo formado, a área de cemento neoformado e a birrefringência do ligamento periodontal reinserido. Conclui-se que a administração intermitente de PTH (1-34), em modelo experimental de reparo em de ratos, pode influenciar positivamente o processo de reparação óssea e periodontal. Abstract: The intermittent PTH administration is known to contribute to bone formation in cases of osteoporosis and bone fractures. Also, it has been reported to reduce periodontitis-related bone loss. The aim of this study was to evaluate the effect of anabolic PTH on periodontal repair and mandibular bone defect in rats. Fenestration defects were created unilaterally at the buccal surface of distal roots of lower first molars in Wistar rats (n=32), and both periodontal ligament and cementum were removed. Animals were then assigned to 4 groups (n=8): 1) C14 - placebo administration for 14 days; 2) P14 - PTH administration for 14 days; 3) C21 - placebo administration for 21 days; and 4) P21 - PTH administration for 21 days. All groups were treated intermittently (3 times a week). All animals were killed and prepared to histomorphometric analysis considering the following parameters: I - extension of the initial defect; II - extension of the remaining defect; III - area of the remaining defect; IV - density of neoformed bone; V - total callus area and staining for tartrate-resistant acidic phosphatase (TRAP); VI - area of the neoformed cementum; VII - polarized light microscopic analysis of root periodontal ligament reattachment. Intergroup analysis showed that the bone defects were initially similar in size (p>0.05). The intermittent PTH administration decreased (p<0.05) both extension and area of the remaining defect, and increased (p<0.05) the neoformed bone density and the total callus area. An increase in TRAP-positive cells was observed in the PTH treated groups (p<0.05). The area of the neoformed cementum and reattachment of the periodontal ligament were also observed to increase concerning PTH-treated groups (p<0.05). Data analysis suggests that the intermittent PTH administration might contribute to bone and periodontal repair in rats. Doutorado Histologia e Embriologia Doutor em Biologia Buco-Dental

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Silva, Karla Rovaris da 1987. "Estudo da organização do colágeno e resistência do ligamento periodontal em incisivos de ratos irradiados." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288476.

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Orientador: Pedro Duarte Novaes Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba Made available in DSpace on 2018-08-22T06:39:35Z (GMT). No. of bitstreams: 1 Silva_KarlaRovarisda_M.pdf: 5383756 bytes, checksum: f46eb2dfd48068a21c19841f2e4d3581 (MD5) Previous issue date: 2013 Resumo: Os efeitos adversos da radioterapia sobre os tecidos orais vêm sendo estudados com intuito de, cada vez mais, entender como esta age sobre o organismo, bem como para o desenvolvimento de métodos ou substâncias que visem à minimização dessas sequelas. Dentre os tecidos que estão na área de exposição, está o ligamento periodontal, que se afetado, pode ocasionar a perna dentária que impreterivelmente interfere na qualidade de vida do indivíduo. Este trabalho teve como objetivo avaliar o efeito da radiação ionizante sobre o ligamento periodontal do dente incisivo de rato albinus wistar, por meio da microscopia de polarização e do teste de força. A amostra constituiu-se de 30 ratos albinus wistar machos divididos em dois grupos, o grupo controle (15) e o grupo irradiado (15). O grupo irradiado foi submetido à sessão única de radioterapia com dose de 15Gy e após 14 dias todos os animais foram sacrificados. Um animal de cada grupo foi perdido durante a execução do trabalho. Desta forma, sete animais de cada grupo foram submetidos ao teste de resistência do ligamento periodontal e os sete restantes tiveram a organização do colágeno avaliada através da microscopia de polarização. Os resultados mostraram que ambos os testes apresentaram diferença estatisticamente significante entre os grupos (p<0,001). Através dos coeficientes de correlação de Pearson encontrou-se também uma forte correlação entre os resultados dos testes (resistência/polarização) de cada grupo (controle/irradiado) (R = 0,683; p < 0,001). Portanto, concluiu-se que a radioterapia pode levar à diminuição da resistência à força de intrusão e provocou a desorganização do colágeno no ligamento periodontal Abstract: The adverse effects of radiotherapy on oral tissues have been studied in order to increasingly understand how it works on the body, as well as for the development of methods and substances aimed at minimizing these sequelae. Among the tissues that are in the exposition area, is the periodontal ligament which, when affected, can lead to tooth loss, that unfailingly interferes with quality of life. This study had as purpose to evaluate the effect of ionizing radiation over the periodontal ligament of the incisive tooth of the albinus wistar rat, trough the polarizing microscope and the strength test. The sample was composed of 30 albinus wistar male rats, separated into two groups, the control group (15) and the irradiated one (15). The irradiated group was subjected to an only session of radiotherapy, with a 15Gy dose, and after 14 days all the animals were sacrificed. One animal in each group was lost during the study's execution. Hence, seven animals of each group were subjected to the periodontal's ligament resistance test, and the seven remaining had their collagen organization evaluated trough the polarizing microscopy. The results showed that both tests exhibited statistically significance difference between the groups (p<0,001). Using the Pearson correlation coefficients a strong correlation was also found between the tests results (resistance/polarizing) of each group (control/irradiated) (R = 0,683; p<0,0001). Thereby, the conclusion was that radiotherapy can lead to a diminished resistance to the intrusion strength and to a disorganization of the periodontal's ligament collagen Mestrado Radiologia Odontologica Mestra em Radiologia Odontológica

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Nogueira, Alessandra Fonseca Gambini. "Estudo in vitro do efeito de cones de obturação endodôntica na biomodulação de fibroblastos de ligamento periodontal." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/23/23156/tde-27112017-122839/.

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A obturação do canal radicular é uma etapa fundamental para o sucesso do tratamento endodôntico. É desejável que os materiais empregados nesta fase não interferiram negativamente com o reparo tecidual, mas preferencialmente estimulem a regeneração dos tecidos periapicais. Recentemente, cones de guta-percha combinados com material biocerâmico foram desenvolvidos com esta finalidade. Sendo assim, o objetivo deste estudo foi investigar o potencial citotóxico e biomodulador de cones de guta-percha convencionais, de cones de guta-percha contendo biocerâmica e de cones de polímero sobre células de ligamento periodontal in vitro. Cultura de fibroblastos de ligamento periodontal foi estabelecida a partir de terceiro molar humano. As células foram estimuladas com extratos de cones de guta-percha convencional, de cones de guta-percha contendo biocerâmica e de cones de polímero em diluição seriada para teste de viabilidade celular por meio do método MTT (Brometo de Difeniltetrazólio 3-(4,5-Dimetiltiazol-2-yl) após 72 h. Em seguida, a diluição de 1/5 foi empregada para estimulação das células por 72 h para detecção da expressão gênica de colágeno tipo I e proteína cementária 1 (CEMP-1) por RT-qPCR. Os dados foram estatisticamente analizados por meio de ANOVA sendo considerados significativos valores de p < 0,05. Os resultados observados de forma que, em extrato puro em extrato puro 1:1, houve comprometimento da viabilidade celular tanto para o extrato de cone de guta-percha quanto para o extrato do cone Cpoint podendo ser considerados citotóxicos. Nas outras diluições não houve diferença significativa neste parâmetro. Em relação à expressão gênica de colágeno, não foram observadas diferenças significativas quando da presença dos extratos. Para CEMP-1, significativa indução da expressão gênica foi observada para o cone de guta-percha. Conclui-se, através da análise dos resultados, que o cone de guta-percha e o cone de polímero são os mais citotóxicos em extrato puro, porém a guta-percha foi o único material que induziu uma expressão significativa de CEMP-1 que auxilia no reparo tecidual. O Col1 não foi induzido em nenhuma das amostras, porém também não foi inibido que indica que nenhum dos 3 tipos de cone interfere no reparo tecidual. Root canal obturation is a fundamental step for successful endodontic treatment. It is desirable that the materials employed at this stage did not adversely interfere with tissue repair but rather stimulate the regeneration of the periapical tissues. Recently, gutta-percha points combined with bioceramic materials were developed for this purpose. Thus, the objective of this study was to investigate the cytotoxic and biomodulatory potential of conventional gutta-percha points, gutta-percha points containing bioceramics and polymer points on periodontal ligament cells in vitro. Culture of periodontal ligament fibroblasts was established from one human third molar. The cells were stimulated with extracts of cones of conventional gutta-percha points, gutta-percha containing bioceramics and polymer points in serial dilution for cell viability test using the MTT assay [Diphenyltetrazolium Bromide 3- (4,5)]. Next, the 1/5 dilution was used to stimulate the cells for 72 h to detect the gene expression of type I collagen and cement protein 1 (CEMP-1) by RT-qPCR. Data were statistically analyzed by means of ANOVA being considered significant values of p <0.05. The results observed was that in a pure 1: 1 extract, there was impairment of cell viability for both the guta-percha cone extract and the Cpoint cone extract and could be considered cytotoxic. At the other dilutions, no significant difference on this parameter was observed. Regarding the gene expression of collagen, no significant differences were observed at the presence of extracts. For CEMP-1, significant induction of gene expression was observed for gutta-percha points. In conclusion, the analysis of the results showed that the gutta-percha and polymer points are the most cytotoxic at pure extract, however gutta-percha was the only material that induced a significant expression of CEMP-1 which assists the tissue repair. Col1 was not induced in any of the samples but was also not inhibited indicating that none of the 3 cone types interfere in tissue repair.

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Carvalho, Helen Ramon Esper de. "Remoção mecânica do ligamento periodontal cementário necrosado com escova de Robinson e pedra pomes e com lâmina de bisturi. Análise histomorfométrica e MEV /." Araçatuba : [s.n.], 2004. http://hdl.handle.net/11449/88929.

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Orientador: Sônia Regina Panzarini Barioni Resumo: Um dos fatores importantes no sucesso do reimplante dentário tardio parece ser dependente do tipo de tratamento da superfície radicular. Esse tratamento inclui a remoção do ligamento periodontal cementário necrótico que pode favorecer o aparecimento das reabsorções radiculares externas, maior causa da perda dos dentes reimplantados nessas condições. O objetivo desse estudo foi comparar a efetividade de duas técnicas de remoção mecânica do ligamento periodontal cementário necrosado e a preservação da camada de cemento. Foram utilizadas 45 raízes de pré-molares hígidos extraídos com finalidade ortodôntica. Após a extração os dentes permaneceram por um período de uma hora em meio ambiente e passado esse tempo foram imersos em soro fisiológico por mais dez minutos. A partir desse passo foram divididos em 3 grupos experimentais. Grupo 1: controle, o ligamento periodontal cementário foi mantido. Grupo 2: remoção do ligamento periodontal cementário por meio de raspagem com lâmina de bisturi (RLB). Grupo 3: remoção do ligamento periodontal cementário por meio de escova de Robinson montada em baixa rotação e pasta de pedra pomes e água (RER). Após processamento das peças foram feitos cortes transversais e longitudinais nessas raízes para análise em microscopia óptica e eletrônica de varredura (MEV). Pela análise qualitativa e quantitativa dos resultados concluiu-se que a técnica RER foi mais eficiente que a RLB quanto à remoção do ligamento periodontal cementário, porém ambas preservaram a camada de cemento. Abstract: One of the important features related to the success of delayed tooth replantation seems to depend on the type of root surface treatment. This treatment encloses the removal of necrotic cemental periodontal ligament, which may favors the occurrence of external root resorptions that are the major cause of loss of teeth replanted in such conditions. The aim of this study was to compare the effectiveness of two techniques for mechanical removal of necrotic cemental periodontal ligament and the preservation of the cementum layer. Forty-five roots of sound premolars extracted for orthodontic purposes were selected. After extraction, the teeth were maintained at room ambient conditions for 1 hour and then immersed in saline for additional 10 minutes. Afterwards, the roots were assigned to three experimental groups. Group 1: control, the cemental periodontal ligament was maintained. Group 2: removal of the cemental periodontal ligament by scaling with a scalpel blade (SBR). Group 3: removal of the cemental periodontal ligament using a Robinson bristle brush, at low-speed, with pumice/water slurry (RBR). After processing of the pieces, the roots were sectioned transversally and longitudinally and the specimens obtained were examined under optical and scanning electron microscopy (SEM). The quantitative and qualitative analyses of the results showed that the RBR technique was more effective than the SBR technique, as regards the removal of the cemental periodontal ligament. Both techniques preserved the cementum layer. Mestre

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Livres sur le sujet "Periodontal ligament"

J, Moxham B., Newman Hubert N, and Berkovitz B. K. B, eds. The periodontal ligament in health and disease. 2nd ed. London: Mosby-Wolfe, 1995.

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Loescher, Alison Ruth. Studies on the innervation of the periodontal ligament. Birmingham: Universityof Birmingham, 1989.

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Lee, Nancy May. Design and Optimization of an Integrative Periodontal Ligament Scaffold. [New York, N.Y.?]: [publisher not identified], 2016.

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Nguyen, Lan Phan. A critique of the paper "Collagen implants do not preserve periodontal ligament homeostasis in periodontal wounds". [Toronto: University of Toronto, Faculty of Dentistry], 1996.

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A, Norton Louis, Burstone Charles 1928-, and Biology of Tooth Movement Conference (1986 : Farmington, Conn.), eds. The Biology of tooth movement. Boca Raton, Fla: CRC Press, 1989.

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Lin, Deborah G. Storage conditions of avulsed teeth affect the phenotype of cultured human periodontal ligament cells. [Toronto: Faculty of Dentistry, University of Toronto, 1999.

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Hellén-Halme, Kristina. Quality aspects of digital radiography in general dental practice. Malmö: Malmö University, Department of Oral and Maxillofacial Radiology, Faculty of Odontology, 2007.

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Arturo, Natali, ed. Dental biomechanics. New York, NY: Taylor & Francis, 2003.

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N, Natali Arturo, ed. Dental biomechanics. London: Taylor & Francis, 2003.

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Berkovitz, B. K. B. The Periodontal Ligament Disease. 2nd ed. Mosby, 1995.

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Chapitres de livres sur le sujet "Periodontal ligament"

Menicanin, Danijela, K. Hynes, J. Han, S. Gronthos, and P. M. Bartold. "Cementum and Periodontal Ligament Regeneration." In Engineering Mineralized and Load Bearing Tissues, 207–36. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22345-2_12.

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Komaki, Motohiro. "Pericytes in the Periodontal Ligament." In Advances in Experimental Medicine and Biology, 169–86. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11093-2_10.

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Mark Bartold, P. "Bone and Tooth Interface: Periodontal Ligament." In Mineralized Tissues in Oral and Craniofacial Science, 217–30. West Sussex, UK: John Wiley & Sons, Inc.,, 2013. http://dx.doi.org/10.1002/9781118704868.ch26.

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Elçin, Y. Murat, Bülend İnanç, and A. Eser Elçin. "Human Embryonic Stem Cell Differentiation on Periodontal Ligament Fibroblasts." In Methods in Molecular Biology, 269–81. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-369-5_14.

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Trubiani, Oriana, and Francesca Diomede. "Xeno-Free Culture of Human Periodontal Ligament Stem Cells." In Methods in Molecular Biology, 87–92. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/7651_2014_122.

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Wilson, A. N., J. Middleton, G. N. Pande, and M. L. Jones. "Nonlinear Behaviour of the Periodontal Ligament a Numerical Approach." In Interfaces in Medicine and Mechanics—2, 309–18. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3852-9_32.

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Issaranggun Na Ayuthaya, Benjar, and Prasit Pavasant. "Influence of Exogenous IL-12 on Human Periodontal Ligament Cells." In Interface Oral Health Science 2016, 217–28. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-1560-1_18.

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Elçin, Y. Murat, Bülend İnanç, and A. Eser Elçin. "Differentiation of Human Embryonic Stem Cells on Periodontal Ligament Fibroblasts." In Methods in Molecular Biology, 223–35. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/7651_2014_130.

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Farag, Amro, Cedryck Vaquette, Dietmar W. Hutmacher, P. Mark Bartold, and Sašo Ivanovski. "Fabrication and Characterization of Decellularized Periodontal Ligament Cell Sheet Constructs." In Methods in Molecular Biology, 429–38. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2780-8_25.

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Moustafa, Mahmoud, Muhammad Najib Roslly, Zuhaila Ismail, Nurul Aini Jaafar, Sharidan Shafie, and Norehan Mokhtar. "Mathematical Modelling and Simulation of Periodontal Ligament Using COMSOL Multiphysics." In Proceedings of the International Conference on Mathematical Sciences and Statistics 2022 (ICMSS 2022), 267–77. Dordrecht: Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-014-5_25.

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Actes de conférences sur le sujet "Periodontal ligament"

Zhang, X., Y. Li, R. Wang, and Z. Wang. "Dose-dependent cytotoxicity and genotoxicity in periodontal ligament fibroblasts induced by cold atmospheric plasma." In 2024 IEEE International Conference on Plasma Science (ICOPS), 1. IEEE, 2024. http://dx.doi.org/10.1109/icops58192.2024.10625997.

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Kafel, N., J. Kolodziejski, M. Niemiera, and M. Reed. "Separation of the periodontal ligament for atraumatic tooth extraction." In 2014 40th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2014. http://dx.doi.org/10.1109/nebec.2014.6972830.

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Karam, Leandro Z., Maura S. Milczewski, and Hypolito J. Kalinowski. "Strain monitoring of the periodontal ligament in pig's mandibles." In OFS2012 22nd International Conference on Optical Fiber Sensor, edited by Yanbiao Liao, Wei Jin, David D. Sampson, Ryozo Yamauchi, Youngjoo Chung, Kentaro Nakamura, and Yunjiang Rao. SPIE, 2012. http://dx.doi.org/10.1117/12.975270.

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Maurtgi, Moustafa, Sharlina binti Mohamad, Siti Noor Fazliah Mohd Noor, and Norehan Mokhtar. "Effect of vitamin E on human periodontal ligament fibroblasts." In TRANSLATIONAL CRANIOFACIAL CONFERENCE 2016 (TCC 2016): Proceedings of the 1st Translational Craniofacial Conference 2016. Author(s), 2016. http://dx.doi.org/10.1063/1.4968874.

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Gao, Zhen, and Xiaoting Luo. "Biological Effect of Titanium's Surface Roughness on Periodontal Ligament Cells." In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5162449.

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Menegotto, G. F., L. Grabarski, H. J. Kalinowski, and J. A. Simões. "Trial analysis of swine's periodontal ligament with Bragg grating sensors." In 20th International Conference on Optical Fibre Sensors, edited by Julian D. C. Jones. SPIE, 2009. http://dx.doi.org/10.1117/12.835231.

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Yang, Yu, Wencheng Tang, and Yao jun Wang. "Experimental Analysis of the Elastic Modulus of Periodontal Ligament in Nanoindentation." In ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/detc2016-59040.

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The periodontal ligament (PDL) is a soft connective tissue which exhibits an inhomogeneous, nonlinear, and anisotropic material properties. and the elastic modulus of different positions on each section are not the same, analysis of the material properties of PDL enables a better understanding of biomechanical features for tooth movement. The aim of this study was to study the elastic modulus of different section of PDL in nanoindentation. Experimental results indicate that the average elastic modulus elastic modulus in midroot are lower than cervical margin and apex, and there is large change in the circumferential regions.

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Rahimi, Masoud, and Afsaneh Mojra. "Numerical modeling of hyperfoam behavior of periodontal ligament in mechanical loading." In 2019 26th National and 4th International Iranian Conference on Biomedical Engineering (ICBME). IEEE, 2019. http://dx.doi.org/10.1109/icbme49163.2019.9030376.

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Si-Eun Kim, Soo-Hyuk Uhm, Doo-Hoon Song, Chong-Kwan Kim, Kwang-Mahn Kim, Kyoung-Nam Kim, and Jeon-Geon Han. "Enhanced funtion of human periodontal ligament cells cultured on nanoporous titanium surfaces." In 2012 IEEE 39th International Conference on Plasma Sciences (ICOPS). IEEE, 2012. http://dx.doi.org/10.1109/plasma.2012.6383859.

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Zhurov, Alexei I., Sam L. Evans, Catherine A. Holt, and John Middleton. "A Nonlinear Compressible Transversely-Isotropic Viscohyperelastic Constitutive Model of the Periodontal Ligament." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67949.

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The periodontal ligament may be treated as a transversely-isotropic viscohyperelastic fibre-reinforced compressible material which is subject to large deformations and has an essentially nonlinear behavior. Within these assumptions, a continuum constitutive model of the PDL was proposed recently [48], which involves a number of material parameters that have to be identified from experimental data. An optical motion analysis system was developed [26] to collect data on the deformation of the PDL. In the present paper, an advanced version of the model is suggested, which is based on the assumption of the existence of an additive strain-energy function dependent on a number of principal invariants. The sensitivity analysis of the material parameters is performed and a parameter identification technique is suggested.

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Rapports d'organisations sur le sujet "Periodontal ligament"

Pavasant, Prasit, and Tussanee Yongchaitrakul. Influence of mechanical stress on the expression of osteopontin in human periodontal ligament cells. Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.14.

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Background: Mechanical stress such as orthodontic forces can produce mechanical damage and inflammatory reaction in periodontium. Osteopontin (OPN) is a multifunctional cytokine that found to be correlated with periodontal disease progression. As periodontal ligaments (PDL) can be affected by stress and PDL cells are involved in periodontal destruction and remodeling, we aimed to investigate the influence of mechanical stress on the expression and regulation of OPN in human PDL (HPDL) cells. Methods: The mechanical stress was generated by continuous compressive force and the expression of OPN was examined by reverse transcription polymerase chain reaction (RT-PCR) and Western analysis. The application of inhibitors was used to examine the mechanism involved. Results: Both mRNA and protein expression of OPN significantly increased in a force-dependent manner. Increase of receptor activator of nuclear factor kappa B ligand (RANKL) was also observed. Interestingly, application of indomethacin could abolish the induction of RANKL but not that of OPN, suggesting the cyclooxygenase (COX)-independent mechanism for stress-induced OPN expression. In addition, the up-regulation of OPN was diminished by Rho kinase inhibitor, but not by cytochalasin B. Conclusions: Mechanical stress affects OPN expression in HPDL cells via Rho kinase pathway. Since OPN participates in bone resorption and remodeling induced by mechanical and biological signals, these results suggest the significance of stress-induced OPN in HPDL cells in alveolar bone resorption and remodeling.

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Osathanon, Thanaphum. Gene expression profile of continuous and intermittent compressive stress treated human periodontal ligament cells. Faculty of Dentistry Chulalongkorn University, 2019. https://doi.org/10.58837/chula.res.2019.7.

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Mechanical force regulates periodontal ligament cell (PDL) behavior. However, different force types lead to distinct PDL responses. Here, we report that pretreatment with an intermittent compressive force (ICF), but not a continuous compressive force (CCF), promoted human PDL (hPDL) osteogenic differentiation as determined by osteogenic marker gene expression and mineral deposition in vitro. ICF-induced osterix (OSX) expression was inhibited by cycloheximide and monensin. Although CCF and ICF significantly increased extracellular adenosine triphosphate (ATP) levels, pretreatment with exogenous ATP did not affect hPDL osteogenic differentiation. Gene expression profiling of hPDLs subjected to CCF or ICF revealed that extracellular matrix (ECM)-receptor interaction, focal adhesion, and transforming growth factor beta (TGF- β) signaling pathway genes were commonly upregulated, while calcium signaling pathway genes were downregulated in both CCF- and ICF-treated hPDLs. The TGFB1 mRNA level was significantly increased, while those of TGFB2 and TGFB3 were decreased by ICF treatment. In contrast, CCF did not modify TGFB1 expression. Inhibiting TGF- β receptor type I or adding a TGF- β1 neutralizing antibody attenuated the ICF-induced OSX expression. Exogenous TGF- β1 pretreatment promoted hPDL osteogenic marker gene expression and mineral deposition. Additionally, pretreatment with ICF in the presence of TGF- β receptor type I inhibitor attenuated the ICF-induced mineralization. In conclusion, this study reveals the effects of ICF on osteogenic differentiation in hPDLs and implicates TGF- β signaling as one of its regulatory mechanism.

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Sumrejkanchanakij, Piyamas, Prasit Pavasant, and Tusanee Yongchaitrakul. The influence of collagen I on Insulin-like growth factor-I induced Osteopontin expression in human periodontal ligament fibroblasts. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.14.

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Extracellular matrix and growth factors are the crucial factors that regulate healing and regenerating process in human periodontal ligament (HPDL) cells. The purpose of this study was to examine the effects of type I collagen and insulin-like growth factor-I (IGF-I) on osteopontin (OPN) expression. The data showed that OPN expression was significantly decreased when cells were cultured on collagen-coated plates. Addition of IGF-I obviously induced OPN expression only in a collagen-coated condition, suggesting an attenuation effect of IGF-I on OPN expression inhibited by type I collagen. Cells treated with a combination of inhibitory antibody to beta-1 integrin and IGF-I, showed the same level of OPN expression as those of the group treated with either inhibitory antibody to beta-1 integrin or IGF-I alone. These results indicate that IGF-I counteracts with the inhibitory signal from type I collagen through a beta-1 integrin receptor.

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Chansiripornchai, Piyarat, and Thanaphum Osathanon. In vitro differentiation of mesenchymal stem cells from dental and oral tissues into Islet-like cell cluster. Chulalongkorn University, 2013. https://doi.org/10.58837/chula.res.2013.93.

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Diabetes mellitus is a complicated metabolic disorder resulting in hyperglycemia and long-term complications e.g. diabetic encephalopathy and neuropathy. Treatments of diabetes and its complications have faced many obstacles. Trend of stem cells (SCs)-based therapy has been proposed as a novel approach. Though, the study using dental SCs in this regard is yet lacking. In this study, human dental pulp SCs (hDPSCs) and human periodontal ligament SCs (hPDLSCs) were employed. The results illustrated the capability of differentiation toward islet-like cells (ILCs) cluster / insulin-producing cells (IPCs) by hDPSCs and hPDLSCs. In addition, higher capacity of differentiation toward ILCs cluster / IPCs by hDPSCs was apparently showed in respects of colony number, gene and protein marker expression. In addition, the hDPSCs-derived ILCs cluster / IPCs released C-PEPTIDE upon glucose stimulation in dose-dependent manner. After induction, Notch target genes, HES-1 and HEY-1, were upregulated. Notch inhibition during each step or throughout the induction protocol resulted in variation of ILCs cluster / IPCs morphology, mRNA and protein marker expression, and functional property. Thus, the results suggested the capability of dental SCs in differentiation toward ILCs cluster / IPCs which might be implied to the possibility of dental SCs used in diabetes treatment. In addition, Notch signaling might participate in the regulation of dental SCs differentiation toward ILCs cluster / IPCs.

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