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Articles de revues sur le sujet « PIMS model »

Auteur : Grafiati

Publié le 7 juin 2025

Mis à jour le 2 août 2025

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Ubohov, Serhii H., Viktor V. Trokhymchuk, Violetta I. Todorova, and Volodymyr A. Zahoriy. "PROCESS MODEL OF THE PHARMACEUTICAL INTEGRATED MANAGEMENT SYSTEM." Wiadomości Lekarskie 72, no. 2 (2019): 201–8. http://dx.doi.org/10.36740/wlek201902112.

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Introduction: One of the innovative trends in the modern development of the pharmaceutical sector is the introduction of integrated management systems (IMS) at the enterprises for the production and distribution of medicines. The aim: to substantiate and develop a process model and approaches to the regulation and documentation, performance evaluation and improvement of the IMS within the pharmaceutical institution (PI) and hospital pharmaceutical service (HPS). Materials and methods: research materials used: international standards, regulations and guidelines of the Ministry of Health of Ukra

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Tasnim, Nasira, Ghazala Mahmud, and Kiran Javaid. "GNK-PIMS Score: A Predictive Model for Success of External Cephalic Version." Journal of South Asian Federation of Obstetrics and Gynaecology 4, no. 2 (2012): 99–102. http://dx.doi.org/10.5005/jp-journals-10006-1184.

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ABSTRACT Objective To determine association of GNK-PIMS score vs Newmann Peacock score with success of external cephalic version (ECV). Materials and methods This comparative cross-sectional analysis was carried out at MCH center Unit I, PIMS, Islamabad, from 1st January 2006 to 31st December 2009. Characteristics of 166 breech versions performed during study period were integrated into both Newmann Peacock score and GNK-PIMS score. Association of the two scoring systems with success of ECV was determined using Student t-test, correlation coefficient, Chi-square test and Cox and Snell test. Th

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Amador, A., R. V. Canaria, N. Santos, and M. Gomez. "Modified kinetic models for Cr (VI) adsorption in polymer inclusion membranes." IOP Conference Series: Materials Science and Engineering 1195, no. 1 (2021): 012048. http://dx.doi.org/10.1088/1757-899x/1195/1/012048.

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Abstract Hexavalent chromium is a highly toxic environmental inorganic pollutant. To eliminate toxic Cr (VI) ions in natural waters, polymer inclusion membranes (PIMs) have been developed for highly selective metal ion transport applications. The investigation of the effectiveness of Cr (VI) recovery in aqueous solutions using PIMs with varying amounts of plasticizer was studied. The pseudo-first order (PFO) kinetic model was modified to describe the amount of Cr (VI) ions that have accumulated onto the PIMs at a specific time and to evaluate the performance of the PIMs. A quantitative analysi

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Radzyminska-Lenarcik, Elzbieta, Malgorzata Ulewicz, and Ilona Pyszka. "Application of Polymer Inclusion Membranes Doped with Alkylimidazole to Separation of Silver and Zinc Ions from Model Solutions and after Battery Leaching." Materials 13, no. 14 (2020): 3103. http://dx.doi.org/10.3390/ma13143103.

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New materials, such as polymer inclusion membranes, can be used for water and wastewater treatment. In this paper, the selective transport of silver(I) and zinc(II) ions from nitrate solutions through the polymer inclusion membranes (PIMs), which consist of cellulose triacetate as a polymeric support, o-nitrophenyl pentyl ether as a plasticizer, and either 1-hexylimidazole (1) or 1-hexyl-2-methylimidazole (2) as an ion carrier, is studied. Both Zn(II) and Ag(I) model solutions (CM = 0.001 M, pH = 6.5), as well as the solutions after the leaching of a spent battery with a silver–zinc cell (silv

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Lakshmi, D. Shanthana, Sergio Santoro, Elisa Avruscio, Antonio Tagarelli, and Alberto Figoli. "Preparation of Polymer Inclusion Membranes (PIMs) with Ionic Liquid and its Application in Dye Adsorption Process Supported by Statistical Analysis." International Journal of Membrane Science and Technology 2, no. 2 (2015): 65–77. http://dx.doi.org/10.15379/ijmst.v2i2.483.

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Polymer inclusion membranes (PIMs) were prepared via Non-Solvent Induced Phase Separation (NIPS) using polyethersulfone (PES) loaded with a liquid ionic, 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]). Hydrophilic porous PIMs with a controlled morphology were obtained and tested for the removal of reactive blue 19 (RB19) as a model anionic dye. The dye adsorption efficiency depends on several variables i.e. pH, contact time, initial dye concentration, amount and weight of adsorbent (PIMs). The optimal values of these parameters were calculated by the multivariate approach of â€œ

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Hu, Qiaozhi, Fangyuan Tian, Zhaohui Jin, Gongchao Lin, Fei Teng, and Ting Xu. "Developing a Warning Model of Potentially Inappropriate Medications in Older Chinese Outpatients in Tertiary Hospitals: A Machine-Learning Study." Journal of Clinical Medicine 12, no. 7 (2023): 2619. http://dx.doi.org/10.3390/jcm12072619.

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Due to multiple comorbid illnesses, polypharmacy, and age-related changes in pharmacokinetics and pharmacodynamics in older adults, the prevalence of potentially inappropriate medications (PIMs) is high, which affects the quality of life of older adults. Building an effective warning model is necessary for the early identification of PIMs to prevent harm caused by medication in geriatric patients. The purpose of this study was to develop a machine learning-based model for the warning of PIMs in older Chinese outpatients. This retrospective study was conducted among geriatric outpatients in nin

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Singh, Baljit, Jacqueline W. Pearce, Lakshman N. Gamage, Kyathanahalli Janardhan, and Sarah Caldwell. "Depletion of pulmonary intravascular macrophages inhibits acute lung inflammation." American Journal of Physiology-Lung Cellular and Molecular Physiology 286, no. 2 (2004): L363—L372. http://dx.doi.org/10.1152/ajplung.00003.2003.

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Pulmonary intravascular macrophages (PIMs) are present in ruminants and horses. These species are highly sensitive to acute lung inflammation compared with non-PIM-containing species such as rats and humans. There is evidence that rats and humans may also recruit PIMs under certain conditions. We investigated precise contributions of PIMs to acute lung inflammation in a calf model. First, PIMs were recognized with a combination of in vivo phagocytic tracer Monastral blue and postembedding immunohistology with anti-CD68 monoclonal antibody. Second, gadolinium chloride depleted PIMs within 48 h

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Jabri, Fouad F., Yajun Liang, Tariq M. Alhawassi, Kristina Johnell, and Jette Möller. "Potentially Inappropriate Medications in Older Adults—Prevalence, Trends and Associated Factors: A Cross-Sectional Study in Saudi Arabia." Healthcare 11, no. 14 (2023): 2003. http://dx.doi.org/10.3390/healthcare11142003.

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(1) Background: Potentially inappropriate medications (PIMs) in older adults are associated with drug-related problems, adverse health consequences, repeated hospital admissions and a higher risk of mortality. In Saudi Arabia and some Arab countries, studies of PIMs among large cohorts of older adults are limited. This study aimed to determine the prevalence of PIMs, trends and associated factors among outpatient older adults in Saudi Arabia. (2) Methods: A cross-sectional study was carried out. Over three years (2017–2019), data on 23,417 people (≥65 years) were retrieved from outpatient clin

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Alcalde, Berta, Gemma Elias, Spas D. Kolev, et al. "A Comprehensive Study on the Effect of Plasticizers on the Characteristics of Polymer Inclusion Membranes (PIMs): Exploring Butyl Stearate as a Promising Alternative." Membranes 14, no. 1 (2024): 19. http://dx.doi.org/10.3390/membranes14010019.

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This study investigated the influence of various plasticizers commonly used in the manufacture of polymer inclusion membranes (PIMs), such as 2-nitrophenyl octyl ether (NPOE), phthalates, adipates, and sebacates on the mechanical, thermal, and transport properties of membranes. Additionally, butyl stearate (BTS), chosen for its non-toxic nature compared to phthalates and its cost-effectiveness relative to adipates and sebacates, was evaluated as a plasticizer in PIMs for the first time. All plasticizers were incorporated in PIMs made of either cellulose triacetate (CTA) or poly(vinyl chloride)

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Toth, Rachel K., Regina Solomon, and Noel A. Warfel. "Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28." Cells 11, no. 6 (2022): 1006. http://dx.doi.org/10.3390/cells11061006.

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Proviral integration sites for Moloney murine leukemia virus (PIM) kinases are upregulated at the protein level in response to hypoxia and have multiple protumorigenic functions, promoting cell growth, survival, and angiogenesis. However, the mechanism responsible for the induction of PIM in hypoxia remains unknown. Here, we examined factors affecting PIM kinase stability in normoxia and hypoxia. We found that PIM kinases were upregulated in hypoxia at the protein level but not at the mRNA level, confirming that PIMs were upregulated in hypoxia in a hypoxia inducible factor 1-independent manne

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Öztürk, Başak. "Nondiﬀerentiable Desirability Functions: Derivative Free Optimization with MATLAB/NOMAD". Proceedings of International Mathematical Sciences 7, № 1 (2025): 28–39. https://doi.org/10.47086/pims.1645638.

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Nondiﬀerentiable Desirability functions are one of the most preferred multi-response optimiza- tion methods in nonlinear robust parameter design. Their nondiﬀerentiability makes the optimization prob- lem hard to solve and researchers and scientists look for new softwares and new desirability function structures to overcome this problem. In this study, we suggest a new implementation of derivative free mash adaptive direct search algorithm (MADS) with MATLAB/NOMAD to nondiﬀerentiable desirability functions. For doing this, we need to model the optimization problem of desirability functions as

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Soo, Jillin Ai Lam, Muaz Mohd Zaini Makhtar, Noor Fazliani Shoparwe, et al. "Characterization and Kinetic Studies of Poly(vinylidene fluoride-co-hexafluoropropylene) Polymer Inclusion Membrane for the Malachite Green Extraction." Membranes 11, no. 9 (2021): 676. http://dx.doi.org/10.3390/membranes11090676.

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Textile industry effluent contains a high amount of toxic colorants. These dyes are carcinogenic and threats to the environment and living beings. In this study, poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-co-HFP) was used as the based polymer for PIMs with bis-(2-ethylhexyl) phosphate (B2EHP) and dioctyl phthalate (DOP) as the carrier and plasticizer. The fabricated PIMs were employed to extract the cation dye (Malachite Green; MG) from the feeding phase. PIMs were also characterized by scanning electron microscopy (SEM), atomic force microscope (AFM), contact angle, water uptake,

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Gultom, Rossy Melinda. "Workforce Strategy in a Manufacturing Company to Improve PIMS Value." Journal La Sociale 6, no. 3 (2025): 736–50. https://doi.org/10.37899/journal-la-sociale.v6i3.1619.

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The workforce is a critical asset for a manufacturing company to remain competitive. However, the company faces significant challenges in managing its substantial workforce efficiently, such as rising expenditures driven by inflation, minimum wage legislation, and economic growth, which affect the PIMS (Profit Impact of Market Strategy) value. PIMS, a metric used to measure competitiveness by evaluating total blending volume per total expenditure, underscores the importance of controlling annual costs. With salaries, wages, and benefits constituting over half of these costs, a focused study on

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Aguilar, José, Irene Garrigós, Jose-Norberto Mazón, and Juan Trujillo. "An MDA Approach for Goal-oriented Requirement Analysis in Web Engineering." JUCS - Journal of Universal Computer Science 16, no. (17) (2010): 2475–94. https://doi.org/10.3217/jucs-016-17-2475.

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Web designers usually ignore how to model real user expectations and goals, mainly due to the large and heterogeneous audience of the Web. This fact leads to websites which are difficult to comprehend by visitors and complex to maintain by designers. In order to ameliorate this scenario, an approach for using the i* modeling framework in Web engineering has been developed in this paper. Furthermore, due to the fact that most of the existing Web engineering approaches do not consider how to derive conceptual models of the Web application from requirements analysis we also propose the use of MDA

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Lambert, Que T., Anuradha Pradhan, and Gary W. Reuther. "Pims: Potential Therapeutic Targets for Myeloproliferative Neoplasms." Blood 124, no. 21 (2014): 4575. http://dx.doi.org/10.1182/blood.v124.21.4575.4575.

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Abstract Myeloproliferative neoplasms (MPNs) are a group of hematopoietic stem cell disorders characterized by the abnormal production of various myeloid cells. Aberrant JAK2 signaling (e.g. induced by JAK2-V617F) plays an etiological role in MPN formation. While JAK2 inhibitors improve patient symptoms, they do not induce cell death as neoplastic cells appear to be rather insensitive to JAK2 inhibition and effectively rapidly become resistant to treatment. Therefore, the development of additional therapeutic approaches for MPNs is needed. Pim kinases are serine/threonine kinases that protect

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Daşdemir, Ahmet. "On Stakhov Functions and New Hyperboloid Surfaces." Proceedings of International Mathematical Sciences 7, no. 1 (2025): 16–27. https://doi.org/10.47086/pims.1653932.

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This paper presents an investigation into the generalization of hyperbolic Fibonacci sine and cosine functions, as well as Fibonacci spirals. Initially, we establish the main definitions and theoretically model them, listing several special cases. We then uncover fundamental results, including the De Moivre and Pythagorean formulas. Based on these new definitions, we introduce new classes of three-dimensional hyperboloid surfaces and compute their Gauss and mean curvatures. Notably, we demonstrate that these surfaces are geodesic.

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Scheurer, Sebastian, Salvatore Tedesco, Brendan O’Flynn, and Kenneth N. Brown. "Comparing Person-Specific and Independent Models on Subject-Dependent and Independent Human Activity Recognition Performance." Sensors 20, no. 13 (2020): 3647. http://dx.doi.org/10.3390/s20133647.

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The distinction between subject-dependent and subject-independent performance is ubiquitous in the human activity recognition (HAR) literature. We assess whether HAR models really do achieve better subject-dependent performance than subject-independent performance, whether a model trained with data from many users achieves better subject-independent performance than one trained with data from a single person, and whether one trained with data from a single specific target user performs better for that user than one trained with data from many. To those ends, we compare four popular machine lea

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Zhang, Jinggui, Yuanjiang Xiang, Yongfan Li, Dajun Lei, and Lifu Zhang. "Role of anomalous self-steepening in controlling self-accelerating Airy pulses in nonlinear metamaterials." Journal of Nonlinear Optical Physics & Materials 25, no. 01 (2016): 1650010. http://dx.doi.org/10.1142/s0218863516500107.

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The additional dispersive magnetic permeability in metamaterials (MMs) described by the Drude model is able to generate the anomalous self-steepening (SS) effect which can be positive, negative even zero. This provides more great flexibility for us to control ultrashort pulse propagation, when compared with the corresponding case in naturally positive-index materials (PIMs). In this paper, we theoretically investigate the self-accelerating control of Airy pulse through such anomalous SS effect in MMs with a cubic nonlinearity. The emphasis is given to the counterintuitive dynamical behavior di

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Friebe, Michael P., Joseph R. LeGrand, Bryan E. Shepherd, Elizabeth A. Breeden, and Scott D. Nelson. "Reducing Inappropriate Outpatient Medication Prescribing in Older Adults across Electronic Health Record Systems." Applied Clinical Informatics 11, no. 05 (2020): 865–72. http://dx.doi.org/10.1055/s-0040-1721398.

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Abstract Background The American Geriatrics Society recommends against the use of certain potentially inappropriate medications (PIMs) in older adults. Prescribing of these medications correlates with higher rates of hospital readmissions, morbidity, and mortality. Vanderbilt University Medical Center previously deployed clinical decision support (CDS) to decrease PIM prescribing rates, but recently transitioned to a new electronic health record (EHR). Objective The goal of this study was to evaluate PIM prescribing rates for older adults before and after migration to the new EHR system. Metho

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Gkika, Despina A., Volkan Filiz, Sofia Rangou, George Z. Kyzas, and Athanasios C. Mitrοpoulos. "Cost Profile of Membranes That Use Polymers of Intrinsic Microporosity (PIMs)." Membranes 12, no. 4 (2022): 433. http://dx.doi.org/10.3390/membranes12040433.

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Assessing the financial impact of polymers of intrinsic microporosity, otherwise known as PIMs, at the lab scale has been impeded by the absence of a holistic approach that would envelop all related financial parameters, and most importantly any indirect costs, such as laboratory accidents that have been consistently neglected and undervalued in past assessments. To quantify the cost of PIMs in relation to the risks befalling a laboratory, an innovative cost evaluation approach was designed. This approach consists of three stages. Firstly, a two-fold “window of opportunity” (WO) theory is sugg

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Bousetta, Brahim, Omar El Beggar, and Taoufiq Gadi. "Automating Software Development Process: Analysis-PIMs to Design-PIM Model Transformation." International Journal of Software Engineering and Its Applications 7, no. 5 (2013): 167–96. http://dx.doi.org/10.14257/ijseia.2013.7.5.17.

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Vaughan, Camille P., Ula Hwang, Ann E. Vandenberg, et al. "Early prescribing outcomes after exporting the EQUIPPED medication safety improvement programme." BMJ Open Quality 10, no. 4 (2021): e001369. http://dx.doi.org/10.1136/bmjoq-2021-001369.

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Enhancing quality of prescribing practices for older adults discharged from the Emergency Department (EQUIPPED) aims to reduce the monthly proportion of potentially inappropriate medications (PIMs) prescribed to older adults discharged from the ED to 5% or less. We describe prescribing outcomes at three academic health systems adapting and sequentially implementing the EQUIPPED medication safety programme.EQUIPPED was adapted from a model developed in the Veterans Health Administration (VA) and sequentially implemented in one academic health system per year over a 3-year period. The monthly pr

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LUCAS, DEBORAH. "Joint risk of DB pension underfunding and sponsor termination: incorporating option-based projections and valuations into PIMS." Journal of Pension Economics and Finance 14, no. 2 (2015): 172–85. http://dx.doi.org/10.1017/s1474747214000444.

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AbstractWhen a private pension plan sponsor with an underfunded plan becomes insolvent, the difference between the value of the plan's assets and its termination liabilities represents a liability for the Pension Benefit Guaranty Corporation (PBGC). Hence, accurately modeling the joint statistical distribution over time of defined benefit pension underfunding and sponsor terminations is critical for estimating PBGC's prospective cash flows and evaluating its financial position. It appears that the current Pension Insurance Modeling System (PIMS) approach to modeling risk does a reasonable job

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GECZY, CHRISTOPHER C. "Financial market assumptions and pension plan models: a comment on PIMS model asset markets assumptions." Journal of Pension Economics and Finance 14, no. 2 (2015): 127–43. http://dx.doi.org/10.1017/s1474747214000432.

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AbstractThe financial market assumptions of the Pension Benefit Guaranty Corporation (PBGC)'s Pension Insurance Modeling System model are critical inputs to simulations for most apparent uses of the system. They currently appear to be based on a reduced form, ‘classical’ approach to assessing and forecasting the distribution of returns on various classes of input assets, allowing for a fairly sophisticated and useful approach to understanding simulated distributions of potential pension insurance outcomes as well as the net financial status of the PBGC. This technical note discusses some of th

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McDonald, Emily G., Justine L. Estey, Cody Davenport, et al. "Electronic Decision Support for Deprescribing in Older Adults Living in Long-Term Care." JAMA Network Open 8, no. 5 (2025): e2512931. https://doi.org/10.1001/jamanetworkopen.2025.12931.

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ImportancePotentially inappropriate prescribing (PIP) is common, costly, and harmful. Deprescribing potentially inappropriate medications (PIMs) is a priority for improving the health outcomes of older adults. PIP is especially common in long-term care homes, with up to 88% of residents affected.ObjectiveTo assess the efficacy of electronic decision support for deprescribing in long-term care.Design, Setting, and ParticipantsThis stepped-wedge cluster randomized trial took place from August 1, 2021, to October 31, 2022, during the COVID-19 pandemic. The study assessed older adults residing in

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Xing, Zhongfang, Ruiqian Zhang, Zhehui Zhao, et al. "Qualitative Analysis of Novel Flavonoid Adducts from Nerve Agent Tabun-Exposed Arabidopsis thaliana (L.) Based on Quadrupole–Time of Flight Mass Spectrometry." Molecules 28, no. 6 (2023): 2581. http://dx.doi.org/10.3390/molecules28062581.

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Flavonoids are a kind of secondary metabolite which widely exist in plants. They contain a lot of active hydroxyls, which can react with toxic chemicals to produce potential exposure biomarkers. In this article, the model plant Arabidopsis thaliana (L.) was exposed to the nerve agent O-Ethyl N,N-dimethyl phosphoramidocyanidate (Tabun). By comparing with the plant not exposed to Tabun, some characteristic ions were identified by quadrupole–time of flight mass spectrometry in the acetonitrile extract of the exposed leaves. These characteristic ions were selected as parent ions to produce product

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Vandenberg, Ann E., Michelle Kegler, Susan Hastings, Ula Hwang, and Camille Vaughan. "SEQUENTIAL IMPLEMENTATION AS A LEARNING HEALTH ORGANIZATION: THE EQUIPPED GERIATRIC MEDICATION SAFETY MODEL." Innovation in Aging 3, Supplement_1 (2019): S945. http://dx.doi.org/10.1093/geroni/igz038.3434.

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Abstract A learning health organization (LHO) is one that systematically integrates internal data and experience with external evidence to improve internal healthcare practice. Yet collaborative research networks implementing evidence-based interventions across sites with the goal of widespread dissemination are also effectively LHOs. The EQUIPPED (Enhancing Quality of Prescribing Practices for Older Adults Discharged from the Emergency Department) network formed to address an important public health issue: potentially inappropriate medications (PIMs) prescribed to older adults at discharge fr

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Radzymińska-Lenarcik, Elżbieta, Ilona Pyszka, and Włodzimierz Urbaniak. "The Use of Polymer Membranes for the Recovery of Copper, Zinc and Nickel from Model Solutions and Jewellery Waste." Polymers 15, no. 5 (2023): 1149. http://dx.doi.org/10.3390/polym15051149.

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A polymeric inclusion membrane (PIM) consisting of matrix CTA (cellulose triacetate), ONPPE (o-nitrophenyl pentyl ether) and phosphonium salts (Cyphos 101, Cyphos 104) was used for separation of Cu(II), Zn(II) and Ni(II) ions. Optimum conditions for metal separation were determined, i.e., the optimal concentration of phosphonium salts in the membrane, as well as the optimal concentration of chloride ions in the feeding phase. On the basis of analytical determinations, the values of parameters characterizing transport were calculated. The tested membranes most effectively transported Cu(II) and

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Korchi, Ayoub, Mohamed Karim Khachouch, and Younes Lakhrisi. "A Model-Driven Architecture Solution for Multi-Platform Mobile App Development." Tehnički glasnik 18, Special Issue (2024): 110–20. http://dx.doi.org/10.31803/tg-20241004154503.

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This paper presents a comprehensive Model Driven Architecture (MDA) approach for multi-platform mobile app development. We introduce a UML-based metamodel that encapsulates essential mobile app elements, including views, controls, resources, and events. Our approach leverages the Acceleo code generation tool to transform Platform Independent Models (PIMs) adhering to this metamodel into platform-specific source code. We demonstrate the effectiveness of our method through a case study, generating Android user interface code from a sample PIM. The results show that our approach can significantly

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van der Helm, A. W. C., M. Oonincx, T. Lapikas, K. M. van Schagen, and L. C. Rietveld. "A drinking water treatment plant simulator using real-time plant data for enhanced operator training and model evaluation." Water Supply 12, no. 2 (2012): 241–49. http://dx.doi.org/10.2166/ws.2012.132.

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Waterspot is a plant-wide drinking water treatment simulator that has been developed in a 3 year research project. The incorporation of real-time and historical data of on-line water quality measurements, flow measurements, process data and water quality laboratory measurements in the simulator improves the acceptance of model output by technologists, ensures a more realistic training of operators and shows the potential of detecting deviations from the expected water quality and control of the plant. The optimal position of the simulator in the automation architecture was found to be on the p

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Clayton, Tony, and Graham Turner. "Brands, Innovation and Growth: A Pims Study of Brand Value." International Journal of Innovation Management 02, no. 04 (1998): 455–68. http://dx.doi.org/10.1142/s1363919698000201.

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New research on the behaviour and performance of over 200 fast-moving consumer businesses selling through multiple outlets show that: (i) the "economic case" for branding can be demonstrated — there is evidence that brands can help producers bring new products and services to market, and that they help consumers exercise effective choice of "value for money"; (ii) branded producers are more innovative than their non-branded counterparts; (iii) branded producers typically create significantly more value added from investment in innovation; and (iv) non-price competition is particularly strong i

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Keeton, Erika, Sangeetha Palakurthi, Marat Alimzhanov, et al. "AZD1208, a Novel, Potent and Selective Pan PIM Kinase Inhibitor, Demonstrates Efficacy in Models of Acute Myeloid Leukemia." Blood 118, no. 21 (2011): 1540. http://dx.doi.org/10.1182/blood.v118.21.1540.1540.

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Abstract Abstract 1540 The PIM serine/threonine kinase family is composed of three highly homologous members; PIM1, PIM2 and PIM3, identified by the ability of the prototype member PIM1 to drive lymphomagenesis in mice. Upregulation of PIM1 and PIM2 is observed in leukemias and lymphomas, including AML, NHL and CLL, highlighting the potential of these kinases as therapeutic targets in these indications. PIMs are downstream effectors of many cytokine and growth factor signaling pathways and are direct transcriptional targets of STAT transcription factors activated by these pathways. PIMs can ph

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MITCHELL, OLIVIA S. "Overviewing the findings: the Technical Panel Review of the Pension Insurance Modeling System." Journal of Pension Economics and Finance 14, no. 2 (2014): 115–24. http://dx.doi.org/10.1017/s147474721400047x.

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AbstractThe Pension Benefit Guaranty Corporation's (PBGC) Pension Insurance Modeling System (PIMS) is used to evaluate the financial security and resilience of the national program backstopping private defined benefit plans. The Pension Research Council of the Wharton School at the University of Pennsylvania recently convened a Technical Review Panel of experts to review key inputs, outputs, and model assumptions. Our review was intended to provide a formal evaluation of the technical adequacy of the model by outside experts. The papers herein summarize views of each expert on this project. Ke

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Wu, Yongxia, Anusara Daenthanasanmak, Hung Nguyen, et al. "PIM2 Kinase Regulates T-Cell Alloresponses and Graft-Versus-Host Disease in Mice." Blood 126, no. 23 (2015): 3074. http://dx.doi.org/10.1182/blood.v126.23.3074.3074.

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Abstract Allogeneic hematopoietic cell transplantation (HCT) can cure a variety of benign and malignant hematopoietic disorders, but graft-versus-host disease (GVHD) remains a significant source of transplant-related mortality and morbidity. Mature T cells in donor stem cell graft are primarily responsible for the development of acute GVHD. PIM kinases are a family of serine/threonine kinases, including PIM1, PIM2 and PIM3, which are expressed following T-cell activation. The PIM kinases have been shown to inhibit apoptosis as well as to stimulate the cell metabolism and protein synthesis. In

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Mustafa Raza, Aamir Afzal, and Mariyam Sarfraz. "Treatment Cost of Diabetic Patients in PIMS Hospital, Pakistan: A Case Study in Islamabad." BMC Journal of Medical Sciences 1, no. 1 (2020): 10–16. https://doi.org/10.70905/bmcj.01.01.06.

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Objective: To determine the total cost of diabetic care from provider’s perspective in a public hospital; Pakistan Institute of Medical Sciences (PIMS) Materials and Methods: Descriptive study based on retrospective selection 01 year (July, 2014 to June, 2015) of medical records of admitted diabetic patients, Medical Ward-6 of General Medicine at Pakistan Institute of Medical Sciences (PIMS), Islamabad. A step down cost accounting approach was used to estimate the costs. Costs included personnel, equipment, direct and indirect costs. Data about 1,580 admitted diabetic patients. Moreover, infor

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Patel, Onisha, Rajini Brammananth, Weiwen Dai, et al. "Crystal structure of the putative cell-wall lipoglycan biosynthesis protein LmcA from Mycobacterium smegmatis." Acta Crystallographica Section D Structural Biology 78, no. 4 (2022): 494–508. http://dx.doi.org/10.1107/s2059798322001772.

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The bacterial genus Mycobacterium includes important pathogens, most notably M. tuberculosis, which infects one-quarter of the entire human population, resulting in around 1.4 million deaths from tuberculosis each year. Mycobacteria, and the closely related corynebacteria, synthesize a class of abundant glycolipids, the phosphatidyl-myo-inositol mannosides (PIMs). PIMs serve as membrane anchors for hyperglycosylated species, lipomannan (LM) and lipoarabinomannan (LAM), which are surface-exposed and modulate the host immune response. Previously, in studies using the model species Corynebacteriu

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Mudge, Alison, Katherine Radnedge, Karen Kasper, et al. "Effects of a pilot multidisciplinary clinic for frequent attending elderly patients on deprescribing." Australian Health Review 40, no. 1 (2016): 86. http://dx.doi.org/10.1071/ah14219.

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Objective Multimorbidity and associated polypharmacy are risk factors for hospital re-admission. The Targeting Hospitalization Risks in Vulnerable Elders (THRIVE) clinic is a novel multidisciplinary out-patient clinic to improve transitions of care and decrease re-admission risk for older medical patients with frequent hospital admissions. This pilot study examined the effect of the THRIVE model on medication count, tablet load and potentially inappropriate medicines (PIMs). Methods Participants with frequent medical admissions were referred within 2 weeks of discharge from hospital and assess

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Radzyminska-Lenarcik, Elzbieta, Robert Ulewicz, and Malgorzata Ulewicz. "Zinc recovery from model and waste solutions using polymer inclusion membranes (PIMs) with 1-octyl-4-methylimidazole." DESALINATION AND WATER TREATMENT 102 (2008): 211–19. http://dx.doi.org/10.5004/dwt.2018.21826.

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Ahmed, Aqsa, Nasir Jamal, and Umair Saeed. "Strength and Limitation of Biological Paradigm during Pandemic of Covid-19: An Application of Queueing Theory." Journal of Electronics,Computer Networking and Applied Mathematics, no. 41 (December 1, 2023): 1–16. http://dx.doi.org/10.55529/jecnam.41.1.16.

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The coronavirus disorder is an epidemic induced by the SARS-CoV-2 germ. The health region is recognized as one of the most important areas in the service sector due to its direct connection to human well-being, particularly in context of the pandemic COVID-19. The overcrowding of patients in the patient registration department, outpatient department, and pharmacy department is the most important issue facing hospitals these days. The investigation of the patient registration, outpatient, and pharmacy departments of PIMS hospital in Islamabad and Benazir Bhutto hospital in Rawalpindi served as

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Fisher, A. T., and J. Bentley. "Localized ion milling of metallic and ceramic TEM specimens." Proceedings, annual meeting, Electron Microscopy Society of America 44 (August 1986): 830–31. http://dx.doi.org/10.1017/s0424820100145492.

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The utility of localized ion milling in the preparation of metallic and ceramic specimens for TEM and AEM is being evaluated from the standpoint of optimizing procedures and identifying limitations and milling characteristics. The equipment used was a Gatan model 645 precision ion milling system (PIMS). This device is a scanning ion beam instrument with which selected areas of a sample can be imaged by either secondary electron or secondary ion signals and selectively ion milled in a small region within the imaged area. The 1 to 10 keV ion beam can be focussed to a 2 μm spot. Specimens are thi

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Khiati, Nadri, Djelloul Bouchiha, Yahia Atig, and Sofiane Boukli Hacene. "WA2MA: A model-driven approach for reengineering web applications into mobile applications." Edelweiss Applied Science and Technology 9, no. 6 (2025): 1530–44. https://doi.org/10.55214/25768484.v9i6.8185.

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With the increasing prevalence of mobile computing, organizations must adapt legacy web applications to pervasive information systems, ensuring seamless accessibility across diverse devices. This paper introduces WA2MA, a model-driven reengineering approach for systematically transforming web applications into mobile applications. The approach follows a structured three-phase process based on Model-Driven Architecture (MDA) principles: Reverse Engineering, where Platform-Independent Models (PIMs) are extracted to represent the structural and behavioral aspects of the existing web application;

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Zhang, Hongbin, Yueling Wang, Qiuhua Liang, Luke S. Smith, and Chris G. Kilsby. "Non-negative depth reconstruction for a two-dimensional partial inertial inundation model." Journal of Hydroinformatics 16, no. 5 (2014): 1158–77. http://dx.doi.org/10.2166/hydro.2014.131.

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This paper proposes a non-negative depth reconstruction method for improving the numerical performance of a partial inertial model (PIM) for applications involving steep-slope and low-friction conditions. The PIM solves the continuity equation of two-dimensional (2D) shallow water equations (SWEs) with the interface fluxes evaluated by a simplified momentum equation that partially restores the inertial terms. In applying the PIM to flood simulations, a practical challenge is to represent complex topography and to track the moving wet–dry interface without resulting in negative water depths. An

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Verastegui, Manuela, Robert H. Gilman, Yanina Arana, et al. "Taenia solium Oncosphere Adhesion to Intestinal Epithelial and Chinese Hamster Ovary Cells In Vitro." Infection and Immunity 75, no. 11 (2007): 5158–66. http://dx.doi.org/10.1128/iai.01175-06.

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ABSTRACT The specific mechanisms underlying Taenia solium oncosphere adherence and penetration in the host have not been studied previously. We developed an in vitro adhesion model assay to evaluate the mechanisms of T. solium oncosphere adherence to the host cells. The following substrates were used: porcine intestinal mucosal scrapings (PIMS), porcine small intestinal mucosal explants (PSIME), Chinese hamster ovary cells (CHO cells), epithelial cells from ileocecal colorectal adenocarcinoma (HCT-8 cells), and epithelial cells from colorectal adenocarcinoma (Caco-2 cells). CHO cells were used

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Souza, Bianca Oliveira, Lucas Brasileiro Lemos, Tamiles Daiane Borges Santana, et al. "Prevalence of the use of potentially inappropriate medications for elderly people undergoing hemodialysis and association with the fatigue scale." CONTRIBUCIONES A LAS CIENCIAS SOCIALES 18, no. 7 (2025): e19714. https://doi.org/10.55905/revconv.18n.7-361.

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Patients with chronic kidney disease (CKD) tend to experience gradual damage to their muscle structure, leading to fatigue, a common symptom in individuals on hemodialysis. Furthermore, the use of potentially inappropriate medications (PIM) by older adults can cause weight loss, fatigue, falls, and even death. In this context, this article evaluated the prevalence of PIM use for elderly people with CKD on hemodialysis and its association with the fatigue scale. Cross-sectional, descriptive, and analytical epidemiological study, in which medical records were evaluated and interviews were conduc

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li, Zhaoang, Chenyu Lin, David J. Bearss, and Hariprasad Vankayalapati. "Abstract 4587: Development of highly selective, potent, orally available PIM1 inhibitor BLX0631 shows a therapeutics potential in multiple myeloma models." Cancer Research 84, no. 6_Supplement (2024): 4587. http://dx.doi.org/10.1158/1538-7445.am2024-4587.

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Abstract Background: The Proto-oncogenic PIMs family are nuclear and cytoplasmic Ser/Thr kinases (PIM1, PIM2, and PIM3) that are constitutively active and play a vital role in proliferation and survival in Multiple Myeloma (MM). Activated PIM1 kinase can induce progression of the cell cycle, inhibition of apoptosis, and modulation of other signal transduction pathways. Methods: BLX-0631 and a few analogs evaluated against a panel of MM cell lines (EJM, IM-9, L-363, LP-1, MM-1R, MM.1S, MOLP-2, NCI-H929, OPM-2, RPMI8226 and U-266) and primary MM patient samples by CellTiter-Glo® (CTG) assays. Ce

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Al-Hetlani, Entesar, Mohamed O. Amin, C. Grazia Bezzu, and Mariolino Carta. "Spirobifluorene-based polymers of intrinsic microporosity for the adsorption of methylene blue from wastewater: effect of surfactants." Royal Society Open Science 7, no. 9 (2020): 200741. http://dx.doi.org/10.1098/rsos.200741.

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Owing to their high surface area and superior adsorption properties, spirobifluorene polymers of intrinsic microporosity (PIMs), namely PIM-SBF-Me (methyl) and PIM-SBF-tBu ( tert -butyl), were used for the first time, to our knowledge, for the removal of methylene blue (MB) dye from wastewater. Spirobifluorene PIMs are known to have large surface area (can be up to 1100 m 2 g −1 ) and have been previously used mainly for gas storage applications. Dispersion of the polymers in aqueous solution was challenging owing to their extreme hydrophobic nature leading to poor adsorption efficiency of MB.

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Matsumoto, Michiaki, Sae Takemori, and Yoshiro Tahara. "Lactic Acid Permeation through Deep Eutectic Solvents-Based Polymer Inclusion Membranes." Membranes 10, no. 9 (2020): 244. http://dx.doi.org/10.3390/membranes10090244.

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Lactic acid that is prepared by fermentation is a compound in food, cosmetic pharmaceutical, and chemical industries. Since a simple technique is desired that separates lactic acid from the cultures, we propose lactic acid permeation through a poly(vinyl chloride)(PVC)-based membrane that contains deep eutectic solvents (DESs) as a carrier. Lactic acid was successfully permeated through polymer inclusion membranes (PIMs) containing hydrophilic DESs, urea-choline chloride and glucose-choline chloride. The permeation behavior was explained by the facilitated transport mechanism based on the solu

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Chowdhury, Debajyoti, Hiu Fung Yip, Hao Liu, Xuecheng Tai, and Aiping Lu. "Abstract 5412: Redefined chronic inflammatory responses as prognostic markers in glioma: an explainable artificial intelligence model." Cancer Research 83, no. 7_Supplement (2023): 5412. http://dx.doi.org/10.1158/1538-7445.am2023-5412.

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Abstract Introduction: Glioma is an aggressive brain tumor. Many inflammatory mediators within the tumor microenvironment (TME) determine its progression. Unfortunately, no ubiquitous prognostic markers reveal the intricacy between TME and chronic inflammatory responses (CIRs). CIRs used to vary among individuals affecting prognosis. And opting for the best-optimized treatment remains challenging. Methods: We proposed an explainable artificial intelligence (XAI) approach to redefine CIRs as prognostic markers for glioma using 694 and 693 patients’ data derived from The Cancer Genome Atlas (TCG

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Mortsiefer, Achim, Susanne Löscher, Yekaterina Pashutina, et al. "Family Conferences to Facilitate Deprescribing in Older Outpatients With Frailty and With Polypharmacy." JAMA Network Open 6, no. 3 (2023): e234723. http://dx.doi.org/10.1001/jamanetworkopen.2023.4723.

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ImportanceFor older adults with frailty syndrome, reducing polypharmacy may have utility as a safety-promoting treatment option.ObjectiveTo investigate the effects of family conferences on medication and clinical outcomes in community-dwelling older adults with frailty receiving polypharmacy.Design, Setting, and ParticipantsThis cluster randomized clinical trial was conducted from April 30, 2019, to June 30, 221, at 110 primary care practices in Germany. The study included community-dwelling adults aged 70 years or older with frailty syndrome, daily use of at least 5 different medications, a l

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Ford, Kenneth M., James Allen, Niranjan Suri, Patrick J. Hayes, and Robert Morris. "PIM: A Novel Architecture for Coordinating Behavior of Distributed Systems." AI Magazine 31, no. 2 (2010): 9. http://dx.doi.org/10.1609/aimag.v31i2.2261.

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Process integrated mechanisms (PIM) offer a new approach to the problem of coordinating the activity of physically distributed systems or devices. Current approaches to coordination all have well-recognized strengths and weaknesses. We propose a novel architecture to add to the mix, called the Process Integrated Mechanism (PIM), which enjoys the advantages of having a single controlling authority while avoiding the structural difficulties that have traditionally led to its rejection in many complex settings. In many situations, PIMs improve on previous models with regard to coordination, secur

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