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Tesi sul tema "Pathogenesis"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Booler, Helen. "Pathogenetic mechanisms in the dystroglycanopathies pathogenesis." Thesis, Royal Veterinary College (University of London), 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669190.

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2

Khamas, E. J. "Pathogenesis of staphylococcosis." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234678.

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3

deLeeuw, Ronald John. "Mantle cell lymphoma pathogenesis." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/12469.

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Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma with a median patient survival time of 3 years. Although the characteristic t(11;14)(q13;q32) is found in virtually all cases, experimental evidence suggests that this event alone is insufficient to result in lymphoma and secondary genomic alterations are required. Therefore, secondary genetic alterations have been proposed as essential in MCL pathogenesis. Within this thesis I describe the creation of a novel assay to determine segmental copy number alterations at a previously unprecedented resolution. This new assay necessita

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4

Sissons, James Robert. "Pathogenesis of Alanthamoeba encephalitis." Thesis, Birkbeck (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429097.

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5

Cowie, Danielle. "Iron and Tuberculosis pathogenesis." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86566.

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Thesis (MSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Iron is an essential element that plays a role in the process of respiration, oxygen transport and as a principle cofactor to several enzymes. Iron homeostasis is a finely regulated process since excess levels become toxic to healthy cells via the production of reactive oxygen species. A plethora of genes that control several key points throughout this regulatory process have been identified. Research focusing on changes in expression levels and downstream functional effects of these genes has become increasingly important over

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6

Yau, Belinda. "Pathogenesis of pneumococcal meningitis." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12485.

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Streptococcus pneumoniae (SP) meningitis remains a significant cause of global childhood mortality, and a potential epidemic pathogen despite improving vaccinations schemes. Neuropathology in pneumococcal meningitis (PM) is attributed to both bacterial products and the host-mediated proinflammatory response. Proinflammatory cytokine interferon-gamma (IFNγ) is associated with macrophage activation and regulating MHC Class I expression in innate immunity. IFNγ gene knockout (GKO) mice inoculated with ~5 x 103 CFU of SP/mouse were significantly protected against fatal PM, compared to C57Bl/6 WT m

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7

Cartón, García Fernando. "Myosin VB in intestinal pathogenesis." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/458251.

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Miosina VB es una proteína que actúa como un motor molecular usando la energía del ATP para moverse a lo largo de filamentos de actina. Participa en el trafico intracelular de endosomas de reciclaje en la parte subapical de células polarizadas y no polarizadas. Su expresión es muy abundante en el intestino donde participa en el establecimiento y mantenimiento de la polaridad de los enterocitos. Mutaciones en MYO5B causan la enfermedad de inclusión de microvellosidades, in raro trastorno congénito que afecta a las células epiteliales del intestino cursando con diarrea acuosa persistente que sue

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8

Hamoudi, Rifat A. "Molecular pathogenesis of MALT lymphoma." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/238398.

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Mucosa associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH andt(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harbouring such translocation do not respond to Helicobacter pylori eradication, while those without translocation can be cured by antibiotics. To understand the molecular mechanism of MALT lymphoma with and without chromosome translocation, 24 cases (15 translocation-positive and 9 translocation-negative) of MALT lymphomas together with 7 follicular lymphomas and 7 mantle

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9

Alam, Sam Mohammad Kutubul. "Pathogenesis of Langerhans Cell Histiocytosis." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487289.

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The Langerhans cell (LC) is a histiocytic cell that represents a resident immigrant population in the epidermis and functions as a professional antigen presenting cell (APC). Langerhans cell histiocytosis (LCH) is a rare disorder that can affect both adults and children and can involve various organs. Clinically the disease ranges from a solitary lytic bone lesion, which may resolve following curettage, to a disseminated leukaemia-like disease with multiple organ involvement, which can be fatal. Despite considerable advances in our understanding of the disease, the aetiology ofLCH remains obsc

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10

Wang, Eddy Hsi Chun. "The pathogenesis of alopecia areata." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/51360.

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The development of a hair loss disease, alopecia areata (AA), is believed to be associated with the initiation of an autoimmune response triggered by the activation of cytotoxic T-cells (CTLs) by unidentified autoantigen epitopes. The long-term sequelae of AA also have not received investigation beyond clinical observations. I hypothesized that CTLs in AA can be activated by autoantigen epitopes derived from hair follicle (HF) cells and activated CTLs may affect the viability of HF keratinocytes. Furthermore, I hypothesized the development of AA can have adverse effects on heart health and in

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11

Matin, Abdul. "Pathogenesis of Balamuthia amoebic encephalitis." Thesis, Birkbeck (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500082.

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12

Linden, Paul Jan Quirien van der. "On the pathogenesis of endometriosis." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=8348.

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13

Fulcher, Robert Aubrey Kawula Thomas Hardin. "Effectors of Haemophilus ducreyi pathogenesis." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,969.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.

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14

Simard, Marie-Chantal. "Nef pathogenesis in transgenic mice." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103182.

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In order to study the functions of SIV Nef in vivo, in a small animal model, transgenic (Tg) mice expressing the SIVmac239 nef gene, under the control of the human CD4 gene promoter (CD4C) were generated. The transgene was found to be expressed in the same cells targeted by the virus, in vivo. These CD4C/SHIV-nef SIV Tg mice develop a severe AIDS-like disease, including premature death, failure to thrive/weight loss, wasting, thymic atrophy, exhibit an especially low number of peripheral CD8+ T cells as well as low number of peripheral CD4+ T cells, diarrhea, splenomegaly, kidney (interstitial

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15

Elliot-Smith, Elena. "GM1 gangliosidosis : therapy and pathogenesis." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425028.

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16

Cordes, Frank Stephan. "Biophysical studies of bacterial pathogenesis." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404113.

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17

Mehasseb, Mohamed Khairy. "The pathogenesis of uterine adenomyosis." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9048.

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Abstract (sommario):

The exact aetiology and pathogenesis of uterine adenomyosis are not clear. Increased endometrial invasiveness has been proposed in the literature, but without conclusive evidence. This thesis was undertaken to examine the pathogenesis of adenomyosis and the differences between affected and unaffected uteri, testing two possibilities with adenomyosis: (i) that the myometrium is permissive to invasion by a normal basal endometrium, or (ii) that the basal endometrium has a higher invasive potential and penetrates a normal myometrium. To examine the early phases of development of adenomyosis, a mo

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18

Craff, Melody Nikki. "The pathogenesis of fructose toxicity." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620036.

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19

Pettersson, Lisa. "TRANSMISSION AND PATHOGENESIS OF HANTAVIRUS." Doctoral thesis, Umeå universitet, Institutionen för klinisk mikrobiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-99687.

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Hantaviruses are the causative agents of hemorrhagic fever with renal syndrome (HFRS) in Eurasia, and of hantavirus cardiopulmonary syndrome (HCPS) in the Americas. Transmission to humans usually occurs by inhalation of aerosolized virus-contaminated rodent excreta. To date, human-to-human transmission has only been described for the Andes hantavirus. The mode of transmission of Andes hantavirus is not yet known, but transmission through saliva has been suggested. In Sweden, we have one hantavirus that is pathogenic to humans, Puumala virus (PUUV), which is endemic in Central and Northern Euro

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20

Johnson, Patricia A. "The pathogenesis of autoimmune vasculitis." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295394.

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21

Hadden, Robert David Martin. "Pathogenesis of Guillain-Barr syndrome." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394003.

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22

Hackett, A. P. "Investigating pathogenesis of reflux aspiration." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3007474/.

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23

Calvo, Sarah E. "Mitochondrial parts, pathways, and pathogenesis." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/54449.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>In title on title page, the word "Mitochondrial" is spelled "Mitochondial."<br>Mitochondria are cellular compartments that perform essential roles in energy metabolism, ion homeostasis, and apoptosis. Mitochondrial dysfunction causes disease in 1 in 5,000 live births and also has been associated with aging, neurodegeneration, cancer, and diabetes. To systematically explore the function of mitochondria in health and in disease, it is

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24

Everest, Paul Howard. "The pathogenesis of Campylobacter diarrhoea." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34407.

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Campylobacter jejuni/coli are the most common cause of acute diarrhoeal disease in man. The disease is worldwide, affects all age groups, and is mostly sporadic although common source outbreaks are frequently reported. The organism characteristically causes infection of the small intestine with extension into the colon and rectum, the disease being an acute enterocolitis. Illness may be inflammatory, with mucosal oedema and polymorphonuclear infiltration and blood in the faeces, or non-inflammatory with watery diarrhoea. The pathogenesis of the disease is unknown. Bacterial invasion of intesti

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25

Bueno, Carmen Ruiz de Valbuena. "Fabry disease: pathogenesis and hispathology." Doctoral thesis, Faculdade de Medicina da Universidade do Porto, 2011. http://hdl.handle.net/10216/63774.

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26

Marques, Sara Andréia de Barros Costa. "Protothecosis: agent characterization and pathogenesis." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/53701.

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27

Beard, Philippa M. "Epidemiology and pathogenesis of paratuberculosis." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/29893.

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Investigations into three aspects of the epidemiology and pathogenesis of paratuberculosis were undertaken - infection of wildlife with <i>Mycobacterium avium </i>subsp<i> paratuberculosis (M. a. paratuberculosis),</i> the early host immune response mounted against organism, and the influence of host genotype on susceptibility to the disease. The pathology of natural rabbit paratuberculosis was investigated and described, with rabbits exhibiting either mild or severe lesions. The changes noted in the severely affected rabbits included the presence of giant cells containing over 50 nuclei and m

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28

Greenfield, Bethany Patricia Jane. "Metarhizium pathogenesis of mosquito larvae." Thesis, Swansea University, 2014. https://cronfa.swan.ac.uk/Record/cronfa42819.

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29

Islam, M. R. "Pathogenesis of avian reovirus infection." Thesis, University of Liverpool, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383443.

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30

McKay, Siobhan. "The molecular pathogenesis of cholangiocarcinoma." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11098.

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Introduction: Cholangiocarcinoma (CC) is a malignancy of the biliary tract. It has a dismal prognosis and complete surgical resection offers the only chance of cure. The aim of this study was to identify prognostic DNA/microRNA signatures, and to identify key targets and pathways in CC to improve treatment. Methods: We performed a retrospective study to assess the role of surgery and adjuvant therapy on the survival outcomes of patients with CC based on the experience of two institutions. We investigated the molecular pathogenesis of CC assessing DNA copy number alterations and differential mi

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31

Wiskur, Brandt Justin. "Pathogenesis of Klebsiella pneumoniae endophthalmitis." Oklahoma City : [s.n.], 2008.

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32

Aula, Nina. "Molecular pathogenesis of Salla disease." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/aula/.

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33

Beatson, Scott. "Pseudomonas aeruginosa genomics and pathogenesis /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16848.pdf.

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34

Yang, Ian Anthony. "Genetic variation in COPD pathogenesis /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16860.pdf.

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35

Cubie, Heather A. "Human papillomavirus : pathogenesis and immunity." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/27846.

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The involvement of human papilloma virus (HPV) in the aetiology and progression of cervical intraepithelial neoplasia (CIN) is still unresolved. This study was designed to assess the immunological responses to HPV types in patients presenting with varying degrees of CIN and in control groups, using in vitro measures of cellular and humoral responses. Lymphocyte proliferation assays (LPA) were performed using peripheral blood mononuclear cells (PBM) and various papillomavirus (PV) antigens. Twenty -five per cent (23/92) of patients with CIN responded to antigens derived from purified BPV, HPV -

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36

Bueno, Carmen Ruiz de Valbuena. "Fabry disease: pathogenesis and hispathology." Tese, Faculdade de Medicina da Universidade do Porto, 2011. http://hdl.handle.net/10216/63774.

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37

Marques, Sara Andréia de Barros Costa. "Protothecosis: agent characterization and pathogenesis." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/53701.

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38

RECCHIA, DEBORAH. "Steroid Myopathy: Understanding the pathogenesis." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1301291.

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Muscle plasticity is a key element in human health and disease. Exercise is an important element that leads to many positive adaptations, which improve survival and quality of life. Conversely, muscle atrophy is a condition found in many chronic diseases. Atrophy is the oucome of an imbalance between the processes that lead to protein synthesis (MPS) and the processes that lead to muscle protein breakdown (MPB) resulting in net muscle mass loss. Chronic administration of glucocorticoids causes steroid myopathy characterized by muscle weakness, fatigue and atrophy. The primary pathogenetic phe

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39

Gillespie, Stephen Henry. "Infection: pathogenesis, diagnosis, treatment and epidemiology." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485197.

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New drugs for tuberculosis are a major need for international public health. The results of clinical trials focussed on evaluation of fluoroquinolones for pulmonary tuberculosis are presented. From this work have emerged new methods to evaluate clinical trials data that have influenced methodology internationally. Isolates obtained in these studies have been the subject of molecular epidemiological typing methods. This led to the discovery ofpotential false matches in typing data bases. Later studies led to the demonstratiQP of the evolutionary pathways that individual strains take as lineages

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40

Tucker, Tracy. "Pathogenesis of neurofibromatosis 1 associated neurofibromas." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31176.

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Neurofibromatosis 1 (NF1) is an autosomal dominant disease. Neurofibromas, benign tumours that develop from peripheral nerves, are a hallmark feature of NF1. Malignant peripheral nerve sheath tumours (MPNSTs) are one of the leading causes of death in people with NF1. Clinical evidence suggests that most MPNSTs develop from pre-existing plexiform neurofibromas. Most studies treat all NF1-associated neurofibromas as a single entity, ignoring important differences between pathological details, clinical presentation and natural history. I analysed clinical information on 476 probands with NF1 from

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41

Osmond, Ronald Ian William. "Barley family five pathogenesis-related proteins." Title page, abstract and contents only, 2000. http://web4.library.adelaide.edu.au/theses/09APSP/09apspo83.pdf.

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Bibliography: leaves 119-143. The work described in this thesis was designed to investigate one component of the plant's defence against pathogen attack, namely the production of PR-5 proteins... Several roles have been proposed for PR-5 proteins including adaption of plant cells to osmotic stress, antifreeze activity, polysaccharide hydrolase activity, fungal plasma membrane pore forming activity, and a-amylase/trypsin inhibition. The experiments that are described in the thesis were aimed at defining the function of barley PR-5 proteins.(abstract)

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42

Hindersson, Maria. "Coxsackie B virus pathogenesis in mice /." Stockholm : Karolinska institutet, 2006. http://diss.kib.ki.se/2006/20060608hind/.

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43

Björkholm, Britta. "Helicobacter pylori : cellular interactions and pathogenesis /." Stockholm : [Karolinska institutets bibl.], 2001. http://diss.kib.ki.se/2001/91-7349-084-9/.

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44

Dahl, Helena. "Epidemiology and pathogenesis of HHV-6 /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-100-4/.

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45

Klingström, Jonas. "Hantaviruses : animal models, immunology and pathogenesis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-071-0/.

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46

Jong, Ype Peter de. "Pathogenesis of immune-mediated murine colitis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/64772.

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47

Bonhoeffer, Sebastian. "Models of viral evolution and pathogenesis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294217.

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48

Fahim, Ahmed. "The pathogenesis of idiopathic pulmonary fibrosis." Thesis, University of Hull, 2011. http://hydra.hull.ac.uk/resources/hull:5296.

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Idiopathic pulmonary fibrosis (IPF) is a restrictive pulmonary disorder of unknown aetiology with a relentless disease course and a median survival of 3 years after the diagnosis. It is the most common idiopathic interstitial lung disease (ILD) with a basal and peripheral predominance associated with temporal and geographical heterogeneity. As the pathogenesis of this disease is poorly understood, the aim of this work was to investigate the pathobiology of IPF in a prospective manner. There is evidence of a strong association of gastro-esophageal reflux and vascular disease with IPF. Moreover,

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49

Scully, Marie Ann. "The pathogenesis of thrombotic Thrombocytopenic Purpura." Thesis, University College London (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498417.

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50

容振威 and Chun-wai Yung. "A molecular study of NPC pathogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31212748.

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